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Identification
NameRopinirole
Accession NumberDB00268  (APRD00302)
TypeSmall Molecule
GroupsApproved, Investigational
Description

Ropinirole is a non-ergoline dopamine agonist, manufactured by GlaxoSmithKline. It is used in the treatment of Parkinson’s disease, and is also one of two medications in the United States with an FDA-approved indication for the treatment of restless legs syndrome (the other being Pramipexole). [Wikipedia]

Structure
Thumb
Synonyms
Ropinirol
Ropinirole
Ropinirolum
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Act Ropiniroletablet5 mgoralActavis Pharma Company2009-07-22Not applicableCanada
Act Ropiniroletablet2 mgoralActavis Pharma Company2009-07-22Not applicableCanada
Act Ropiniroletablet1 mgoralActavis Pharma Company2009-07-22Not applicableCanada
Act Ropiniroletablet0.25 mgoralActavis Pharma Company2009-07-22Not applicableCanada
Dom-ropiniroletablet1.0 mgoralDominion PharmacalNot applicableNot applicableCanada
Dom-ropiniroletablet5.0 mgoralDominion PharmacalNot applicableNot applicableCanada
Dom-ropiniroletablet0.5 mgoralDominion PharmacalNot applicableNot applicableCanada
Dom-ropiniroletablet0.25 mgoralDominion PharmacalNot applicableNot applicableCanada
Dom-ropiniroletablet2.0 mgoralDominion PharmacalNot applicableNot applicableCanada
Jamp-ropiniroletablet5.0 mgoralJamp Pharma Corporation2010-06-16Not applicableCanada
Jamp-ropiniroletablet2.0 mgoralJamp Pharma Corporation2010-06-16Not applicableCanada
Jamp-ropiniroletablet1.0 mgoralJamp Pharma Corporation2010-06-16Not applicableCanada
Jamp-ropiniroletablet0.25 mgoralJamp Pharma Corporation2010-06-16Not applicableCanada
PHL-ropiniroletablet5.0 mgoralPharmel IncNot applicableNot applicableCanada
PHL-ropiniroletablet2.0 mgoralPharmel IncNot applicableNot applicableCanada
PHL-ropiniroletablet1.0 mgoralPharmel IncNot applicableNot applicableCanada
PHL-ropiniroletablet0.5 mgoralPharmel IncNot applicableNot applicableCanada
PHL-ropiniroletablet0.25 mgoralPharmel IncNot applicableNot applicableCanada
PMS-ropiniroletablet1.0 mgoralPharmascience Inc2009-07-22Not applicableCanada
PMS-ropiniroletablet5.0 mgoralPharmascience Inc2009-07-22Not applicableCanada
PMS-ropiniroletablet0.25 mgoralPharmascience Inc2009-07-22Not applicableCanada
PMS-ropiniroletablet0.5 mgoralPharmascience IncNot applicableNot applicableCanada
PMS-ropiniroletablet2.0 mgoralPharmascience Inc2009-07-22Not applicableCanada
Ran-ropiniroletablet2.0 mgoralRanbaxy Pharmaceuticals Canada Inc.2009-07-22Not applicableCanada
Ran-ropiniroletablet1.0 mgoralRanbaxy Pharmaceuticals Canada Inc.2009-07-22Not applicableCanada
Ran-ropiniroletablet0.25 mgoralRanbaxy Pharmaceuticals Canada Inc.2009-07-22Not applicableCanada
Ran-ropiniroletablet0.5 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Ran-ropiniroletablet5.0 mgoralRanbaxy Pharmaceuticals Canada Inc.2009-07-22Not applicableCanada
Requiptablet, film coated1 mg/1oralPd Rx Pharmaceuticals, Inc.1997-10-01Not applicableUs
Requiptablet0.25 mgoralGlaxosmithkline Inc1997-09-29Not applicableCanada
Requiptablet, film coated.5 mg/1oralGlaxo Smith Kline Llc1997-10-10Not applicableUs
Requiptablet, film coated.25 mg/1oralGlaxo Smith Kline Llc1997-10-10Not applicableUs
Requiptablet, film coated4 mg/1oralGlaxo Smith Kline Llc1999-09-21Not applicableUs
Requiptablet, film coated3 mg/1oralGlaxo Smith Kline Llc2001-06-19Not applicableUs
Requiptablet5 mgoralGlaxosmithkline Inc1997-09-25Not applicableCanada
Requiptablet, film coated5 mg/1oralGlaxo Smith Kline Llc1997-10-10Not applicableUs
Requiptablet2 mgoralGlaxosmithkline Inc1997-09-25Not applicableCanada
Requiptablet, film coated2 mg/1oralGlaxo Smith Kline Llc1997-10-03Not applicableUs
Requiptablet, film coated1 mg/1oralbryant ranch prepack1997-10-01Not applicableUs
Requiptablet1 mgoralGlaxosmithkline Inc1997-09-25Not applicableCanada
Requiptablet, film coated1 mg/1oralGlaxo Smith Kline Llc1997-10-01Not applicableUs
Requip XLtablet, film coated, extended release12 mg/1oralGlaxo Smith Kline Llc2008-11-20Not applicableUs
Requip XLtablet, film coated, extended release2 mg/1oralPhysicians Total Care, Inc.2009-12-18Not applicableUs
Requip XLtablet, film coated, extended release8 mg/1oralGlaxo Smith Kline Llc2008-06-30Not applicableUs
Requip XLtablet, film coated, extended release4 mg/1oralGlaxo Smith Kline Llc2008-06-30Not applicableUs
Requip XLtablet, film coated, extended release2 mg/1oralGlaxo Smith Kline Llc2008-06-30Not applicableUs
Requip XLtablet, film coated, extended release6 mg/1oralGlaxo Smith Kline Llc2009-08-03Not applicableUs
Ropiniroletablet2 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Ropiniroletablet1 mgoralSanis Health Inc2010-07-26Not applicableCanada
Ropiniroletablet1 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Ropiniroletablet0.25 mgoralSanis Health Inc2010-07-26Not applicableCanada
Ropiniroletablet0.25 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Ropiniroletablet2 mgoralSanis Health Inc2010-07-262014-08-01Canada
Ropiniroletablet5 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Ropiniroletablet5 mgoralSanis Health Inc2010-07-26Not applicableCanada
Ropinirole Tabletstablet0.25 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Ropinirole Tabletstablet5.0 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Ropinirole Tabletstablet2.0 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Ropinirole Tabletstablet1.0 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Ropinirole Tabletstablet0.5 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-ropiniroletablet4.0 mgoralApotex IncNot applicableNot applicableCanada
Apo-ropiniroletablet3.0 mgoralApotex IncNot applicableNot applicableCanada
Apo-ropiniroletablet2.0 mgoralApotex IncNot applicableNot applicableCanada
Apo-ropiniroletablet1.0 mgoralApotex IncNot applicableNot applicableCanada
Apo-ropiniroletablet0.5 mgoralApotex IncNot applicableNot applicableCanada
Apo-ropiniroletablet0.25 mgoralApotex IncNot applicableNot applicableCanada
Apo-ropiniroletablet5.0 mgoralApotex IncNot applicableNot applicableCanada
Ropiniroletablet1 mg/1oralAphena Pharma Solutions Tennessee, Llc2008-05-05Not applicableUs
Ropiniroletablet, film coated3 mg/1oralApotex Corp.2013-03-29Not applicableUs
Ropiniroletablet.25 mg/1oralRoxane Laboratories, Inc2008-05-05Not applicableUs
Ropiniroletablet, film coated.5 mg/1oralHeritage Pharmaceuticals Inc.2009-09-18Not applicableUs
Ropiniroletablet, film coated5 mg/1oralApotex Corp.2013-03-29Not applicableUs
Ropiniroletablet5 mg/1oralRoxane Laboratories, Inc2008-05-05Not applicableUs
Ropiniroletablet, film coated, extended release8 mg/1oralTrigen Laboratories, LLC2013-03-14Not applicableUs
Ropiniroletablet, film coated1 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-02-25Not applicableUs
Ropiniroletablet.25 mg/1oralCarilion Materials Management2008-05-05Not applicableUs
Ropiniroletablet, film coated2 mg/1oralGlenmark Pharmaceuticals Inc., Usa2010-02-25Not applicableUs
Ropiniroletablet, film coated, extended release2 mg/1oralDr. Reddys Laboratories Limited2012-06-06Not applicableUs
Ropiniroletablet, film coated, extended release6 mg/1oralSandoz Inc2012-06-06Not applicableUs
Ropiniroletablet2 mg/1oralAphena Pharma Solutions Tennessee, Llc2008-05-05Not applicableUs
Ropiniroletablet, film coated2 mg/1oralApotex Corp.2013-03-29Not applicableUs
Ropiniroletablet, film coated, extended release12 mg/1oralAlembic Pharmaceuticals Limited2013-03-14Not applicableUs
Ropiniroletablet4 mg/1oralRoxane Laboratories, Inc2008-05-05Not applicableUs
Ropiniroletablet, film coated, extended release6 mg/1oralTrigen Laboratories, LLC2013-03-14Not applicableUs
Ropiniroletablet, film coated5 mg/1oralHeritage Pharmaceuticals Inc.2009-09-18Not applicableUs
Ropiniroletablet, film coated1 mg/1oralGlenmark Pharmaceuticals Inc., Usa2010-02-25Not applicableUs
Ropiniroletablet, film coated, extended release4 mg/1oralSandoz Inc2012-06-06Not applicableUs
Ropiniroletablet, film coated1 mg/1oralApotex Corp.2013-03-29Not applicableUs
Ropiniroletablet, film coated, extended release8 mg/1oralAlembic Pharmaceuticals Limited2013-03-14Not applicableUs
Ropiniroletablet, film coated, extended release12 mg/1oralActavis Pharma, Inc.2012-08-23Not applicableUs
Ropiniroletablet, film coated, extended release4 mg/1oralTrigen Laboratories, LLC2013-03-14Not applicableUs
Ropiniroletablet, film coated4 mg/1oralHeritage Pharmaceuticals Inc.2009-10-09Not applicableUs
Ropiniroletablet, film coated.5 mg/1oralGlenmark Pharmaceuticals Inc., Usa2010-02-25Not applicableUs
Ropiniroletablet, film coated, extended release2 mg/1oralSandoz Inc2012-06-06Not applicableUs
Ropiniroletablet3 mg/1oralRoxane Laboratories, Inc2008-05-05Not applicableUs
Ropiniroletablet, film coated, extended release12 mg/1oralDr. Reddys Laboratories Limited2012-06-06Not applicableUs
Ropiniroletablet, film coated, extended release8 mg/1oralActavis Pharma, Inc.2012-08-23Not applicableUs
Ropiniroletablet, film coated.5 mg/1oralApotex Corp.2013-03-29Not applicableUs
Ropiniroletablet, film coated2 mg/1oralDispensing Solutions, Inc.2010-02-25Not applicableUs
Ropiniroletablet, film coated, extended release6 mg/1oralAlembic Pharmaceuticals Limited2013-03-14Not applicableUs
Ropiniroletablet2 mg/1oralRoxane Laboratories, Inc2008-05-05Not applicableUs
Ropiniroletablet, film coated, extended release2 mg/1oralTrigen Laboratories, LLC2013-03-14Not applicableUs
Ropiniroletablet, film coated3 mg/1oralHeritage Pharmaceuticals Inc.2009-09-18Not applicableUs
Ropiniroletablet, film coated.25 mg/1oralGlenmark Pharmaceuticals Inc., Usa2010-02-25Not applicableUs
Ropiniroletablet, film coated, extended release4 mg/1oralActavis Pharma, Inc.2012-08-23Not applicableUs
Ropiniroletablet, film coated.25 mg/1oralApotex Corp.2013-03-29Not applicableUs
Ropiniroletablet, film coated5 mg/1oralGlenmark Pharmaceuticals Inc., Usa2010-02-25Not applicableUs
Ropiniroletablet, film coated, extended release4 mg/1oralAlembic Pharmaceuticals Limited2013-03-14Not applicableUs
Ropiniroletablet, film coated, extended release6 mg/1oralDr. Reddys Laboratories Limited2012-06-06Not applicableUs
Ropiniroletablet1 mg/1oralRoxane Laboratories, Inc2008-05-05Not applicableUs
Ropiniroletablet, film coated2 mg/1oralHeritage Pharmaceuticals Inc.2009-09-18Not applicableUs
Ropiniroletablet, film coated, extended release12 mg/1oralSandoz Inc2012-06-06Not applicableUs
Ropiniroletablet, film coated, extended release2 mg/1oralActavis Pharma, Inc.2012-08-23Not applicableUs
Ropiniroletablet1 mg/1oralCarilion Materials Management2008-05-05Not applicableUs
Ropiniroletablet, film coated4 mg/1oralGlenmark Pharmaceuticals Inc., Usa2010-02-25Not applicableUs
Ropiniroletablet, film coated, extended release2 mg/1oralAlembic Pharmaceuticals Limited2013-03-14Not applicableUs
Ropiniroletablet, film coated, extended release8 mg/1oralDr. Reddys Laboratories Limited2012-06-06Not applicableUs
Ropiniroletablet, film coated.25 mg/1oralHeritage Pharmaceuticals Inc.2009-09-18Not applicableUs
Ropiniroletablet.25 mg/1oralAphena Pharma Solutions Tennessee, Llc2008-05-05Not applicableUs
Ropiniroletablet, film coated4 mg/1oralApotex Corp.2013-03-29Not applicableUs
Ropiniroletablet.5 mg/1oralRoxane Laboratories, Inc2008-05-05Not applicableUs
Ropiniroletablet, film coated1 mg/1oralHeritage Pharmaceuticals Inc.2009-09-18Not applicableUs
Ropiniroletablet, film coated, extended release6 mg/1oralActavis Pharma, Inc.2012-08-23Not applicableUs
Ropiniroletablet, film coated, extended release12 mg/1oralTrigen Laboratories, LLC2013-03-14Not applicableUs
Ropiniroletablet.5 mg/1oralCarilion Materials Management2008-05-05Not applicableUs
Ropiniroletablet, film coated3 mg/1oralGlenmark Pharmaceuticals Inc., Usa2010-02-25Not applicableUs
Ropiniroletablet, film coated, extended release4 mg/1oralDr. Reddys Laboratories Limited2012-06-06Not applicableUs
Ropiniroletablet, film coated, extended release8 mg/1oralSandoz Inc2012-06-06Not applicableUs
Ropinirole Hydrochloridetablet, film coated, extended release4 mg/1oralMylan Pharmaceuticals Inc.2012-10-16Not applicableUs
Ropinirole Hydrochloridetablet, film coated, extended release6 mg/1oralWatson Laboratories, Inc.2012-06-06Not applicableUs
Ropinirole Hydrochloridetablet, coated5 mg/1oralRebel Distributors Corp2008-05-21Not applicableUs
Ropinirole Hydrochloridetablet, film coated.25 mg/1oralWockhardt USA LLC.2008-05-29Not applicableUs
Ropinirole Hydrochloridetablet, film coated2 mg/1oralCadila Healthcare Limited2009-09-23Not applicableUs
Ropinirole Hydrochloridetablet, film coated1 mg/1oralZydus Pharmaceuticals (USA) Inc.2009-09-23Not applicableUs
Ropinirole Hydrochloridetablet, film coated1 mg/1oralAmerican Health Packaging2013-07-052016-01-05Us
Ropinirole Hydrochloridetablet, film coated.25 mg/1oralAlembic Pharmaceuticals Inc.2016-01-29Not applicableUs
Ropinirole Hydrochloridetablet, film coated5 mg/1oralAlembic Pharmaceuticals Limited2013-09-12Not applicableUs
Ropinirole Hydrochloridetablet, film coated.5 mg/1oralWockhardt Limited2008-05-29Not applicableUs
Ropinirole Hydrochloridetablet, film coated3 mg/1oralMajor Pharmaceuticals2009-07-08Not applicableUs
Ropinirole Hydrochloridetablet.5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-10-27Not applicableUs
Ropinirole Hydrochloridetablet, film coated, extended release8 mg/1oralMylan Pharmaceuticals Inc.2012-10-16Not applicableUs
Ropinirole Hydrochloridetablet, film coated5 mg/1oralMajor Pharmaceuticals2009-07-08Not applicableUs
Ropinirole Hydrochloridetablet, film coated2 mg/1oralWockhardt Limited2008-05-29Not applicableUs
Ropinirole Hydrochloridetablet, film coated1 mg/1oralWockhardt USA LLC.2008-05-29Not applicableUs
Ropinirole Hydrochloridetablet, film coated4 mg/1oralCadila Healthcare Limited2009-09-23Not applicableUs
Ropinirole Hydrochloridetablet, film coated3 mg/1oralZydus Pharmaceuticals (USA) Inc.2009-09-23Not applicableUs
Ropinirole Hydrochloridetablet, film coated1 mg/1oralAvera Mc Kennan Hospital2015-03-11Not applicableUs
Ropinirole Hydrochloridetablet, film coated1 mg/1oralAlembic Pharmaceuticals Inc.2016-01-29Not applicableUs
Ropinirole Hydrochloridetablet, film coated.25 mg/1oralSolco healthcare U.S., LLC2011-09-20Not applicableUs
Ropinirole Hydrochloridetablet, coated1 mg/1oralPhysicians Total Care, Inc.2008-05-21Not applicableUs
Ropinirole Hydrochloridetablet5 mg/1oralMylan Pharmaceuticals Inc.2008-05-05Not applicableUs
Ropinirole Hydrochloridetablet, film coated, extended release8 mg/1oralWockhardt Limited2012-08-15Not applicableUs
Ropinirole Hydrochloridetablet, film coated.25 mg/1oralZhejiang Huahai Pharmaceutical Co., Ltd.2011-08-10Not applicableUs
Ropinirole Hydrochloridetablet, film coated, extended release4 mg/1oralWockhardt USA LLC.2012-08-15Not applicableUs
Ropinirole Hydrochloridetablet, film coated5 mg/1oralSolco healthcare U.S., LLC2011-09-20Not applicableUs
Ropinirole Hydrochloridetablet, coated1 mg/1oralRebel Distributors Corp2008-05-21Not applicableUs
Ropinirole Hydrochloridetablet, film coated5 mg/1oralZhejiang Huahai Pharmaceutical Co., Ltd.2011-08-10Not applicableUs
Ropinirole Hydrochloridetablet, film coated1 mg/1oralCadila Healthcare Limited2009-09-23Not applicableUs
Ropinirole Hydrochloridetablet, film coated.5 mg/1oralZydus Pharmaceuticals (USA) Inc.2009-09-23Not applicableUs
Ropinirole Hydrochloridetablet, film coated.5 mg/1oralAmerican Health Packaging2013-07-052016-01-05Us
Ropinirole Hydrochloridetablet, film coated4 mg/1oralAlembic Pharmaceuticals Limited2013-09-12Not applicableUs
Ropinirole Hydrochloridetablet, film coated.25 mg/1oralWockhardt Limited2008-05-29Not applicableUs
Ropinirole Hydrochloridetablet, film coated2 mg/1oral; oralMajor Pharmaceuticals2009-07-08Not applicableUs
Ropinirole Hydrochloridetablet, film coated, extended release2 mg/1oralMylan Pharmaceuticals Inc.2012-10-16Not applicableUs
Ropinirole Hydrochloridetablet, film coated, extended release8 mg/1oralWatson Laboratories, Inc.2012-06-06Not applicableUs
Ropinirole Hydrochloridetablet4 mg/1oralMylan Pharmaceuticals Inc.2008-05-05Not applicableUs
Ropinirole Hydrochloridetablet, film coated, extended release4 mg/1oralWockhardt Limited2012-08-15Not applicableUs
Ropinirole Hydrochloridetablet, film coated.25 mg/1oralbryant ranch prepack2009-09-18Not applicableUs
Ropinirole Hydrochloridetablet, film coated, extended release2 mg/1oralWockhardt USA LLC.2012-08-15Not applicableUs
Ropinirole Hydrochloridetablet, film coated2 mg/1oralAmerican Health Packaging2014-01-20Not applicableUs
Ropinirole Hydrochloridetablet, film coated.5 mg/1oralAvera Mc Kennan Hospital2015-06-05Not applicableUs
Ropinirole Hydrochloridetablet, film coated4 mg/1oralSolco healthcare U.S., LLC2011-09-20Not applicableUs
Ropinirole Hydrochloridetablet, coated5 mg/1oralPhysicians Total Care, Inc.2010-09-08Not applicableUs
Ropinirole Hydrochloridetablet, film coated.5 mg/1oralRebel Distributors Corp2009-09-18Not applicableUs
Ropinirole Hydrochloridetablet, film coated, extended release12 mg/1oralAv Kare, Inc.2013-09-13Not applicableUs
Ropinirole Hydrochloridetablet, film coated4 mg/1oralZhejiang Huahai Pharmaceutical Co., Ltd.2011-08-10Not applicableUs
Ropinirole Hydrochloridetablet, film coated.5 mg/1oralCadila Healthcare Limited2009-09-23Not applicableUs
Ropinirole Hydrochloridetablet, film coated.25 mg/1oralZydus Pharmaceuticals (USA) Inc.2009-09-23Not applicableUs
Ropinirole Hydrochloridetablet, film coated.25 mg/1oralAmerican Health Packaging2013-07-052016-01-05Us
Ropinirole Hydrochloridetablet, film coated3 mg/1oralAlembic Pharmaceuticals Limited2013-09-12Not applicableUs
Ropinirole Hydrochloridetablet, film coated1 mg/1oralCardinal Health2014-01-20Not applicableUs
Ropinirole Hydrochloridetablet, film coated1 mg/1oralMajor Pharmaceuticals2009-07-08Not applicableUs
Ropinirole Hydrochloridetablet, film coated, extended release4 mg/1oralWatson Laboratories, Inc.2012-06-06Not applicableUs
Ropinirole Hydrochloridetablet, film coated, extended release2 mg/1oralWockhardt Limited2012-08-15Not applicableUs
Ropinirole Hydrochloridetablet, film coated2 mg/1oralbryant ranch prepack2009-09-18Not applicableUs
Ropinirole Hydrochloridetablet, film coated5 mg/1oralWockhardt USA LLC.2008-05-29Not applicableUs
Ropinirole Hydrochloridetablet, film coated1 mg/1oralAmerican Health Packaging2014-01-20Not applicableUs
Ropinirole Hydrochloridetablet, film coated5 mg/1oralAlembic Pharmaceuticals Inc.2016-01-29Not applicableUs
Ropinirole Hydrochloridetablet, film coated3 mg/1oralSolco healthcare U.S., LLC2011-09-20Not applicableUs
Ropinirole Hydrochloridetablet, coated.5 mg/1oralPhysicians Total Care, Inc.2008-10-22Not applicableUs
Ropinirole Hydrochloridetablet3 mg/1oralMylan Pharmaceuticals Inc.2008-05-05Not applicableUs
Ropinirole Hydrochloridetablet, film coated2 mg/1oralAlembic Pharmaceuticals Limited2013-09-12Not applicableUs
Ropinirole Hydrochloridetablet, film coated.5 mg/1oralMajor Pharmaceuticals2009-07-08Not applicableUs
Ropinirole Hydrochloridetablet, film coated, extended release12 mg/1oralWatson Laboratories, Inc.2012-06-06Not applicableUs
Ropinirole Hydrochloridetablet, coated.25 mg/1oralRebel Distributors Corp2008-05-21Not applicableUs
Ropinirole Hydrochloridetablet, film coated, extended release8 mg/1oralAv Kare, Inc.2013-09-13Not applicableUs
Ropinirole Hydrochloridetablet, film coated3 mg/1oralZhejiang Huahai Pharmaceutical Co., Ltd.2011-08-10Not applicableUs
Ropinirole Hydrochloridetablet, film coated.25 mg/1oralCadila Healthcare Limited2009-09-23Not applicableUs
Ropinirole Hydrochloridetablet, film coated3 mg/1oralAvera Mc Kennan Hospital2015-03-23Not applicableUs
Ropinirole Hydrochloridetablet, film coated2 mg/1oralSolco healthcare U.S., LLC2011-09-20Not applicableUs
Ropinirole Hydrochloridetablet, coated.25 mg/1oralPhysicians Total Care, Inc.2008-10-22Not applicableUs
Ropinirole Hydrochloridetablet3 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-10-27Not applicableUs
Ropinirole Hydrochloridetablet2 mg/1oralMylan Pharmaceuticals Inc.2008-05-05Not applicableUs
Ropinirole Hydrochloridetablet, film coated5 mg/1oralWockhardt Limited2008-05-29Not applicableUs
Ropinirole Hydrochloridetablet, film coated.5 mg/1oralbryant ranch prepack2011-09-20Not applicableUs
Ropinirole Hydrochloridetablet, film coated4 mg/1oralWockhardt USA LLC.2008-05-29Not applicableUs
Ropinirole Hydrochloridetablet, film coated.5 mg/1oralAmerican Health Packaging2014-01-20Not applicableUs
Ropinirole Hydrochloridetablet, film coated4 mg/1oralAlembic Pharmaceuticals Inc.2016-01-29Not applicableUs
Ropinirole Hydrochloridetablet, film coated.25 mg/1oralMajor Pharmaceuticals2009-07-08Not applicableUs
Ropinirole Hydrochloridetablet, film coated, extended release2 mg/1oralWatson Laboratories, Inc.2012-06-06Not applicableUs
Ropinirole Hydrochloridetablet2 mg/1oralSTAT Rx USA LLC2009-09-17Not applicableUs
Ropinirole Hydrochloridetablet, film coated, extended release6 mg/1oralAv Kare, Inc.2013-09-13Not applicableUs
Ropinirole Hydrochloridetablet, film coated2 mg/1oralZhejiang Huahai Pharmaceutical Co., Ltd.2011-08-10Not applicableUs
Ropinirole Hydrochloridetablet, film coated, extended release6 mg/1oralWockhardt USA LLC.2012-08-15Not applicableUs
Ropinirole Hydrochloridetablet, film coated.25 mg/1oralDispensing Solutions, Inc.2009-09-18Not applicableUs
Ropinirole Hydrochloridetablet, film coated1 mg/1oralAlembic Pharmaceuticals Limited2013-09-12Not applicableUs
Ropinirole Hydrochloridetablet, film coated1 mg/1oralSolco healthcare U.S., LLC2011-09-20Not applicableUs
Ropinirole Hydrochloridetablet, coated4 mg/1oralPhysicians Total Care, Inc.2008-07-02Not applicableUs
Ropinirole Hydrochloridetablet2 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-10-27Not applicableUs
Ropinirole Hydrochloridetablet1 mg/1oralMylan Pharmaceuticals Inc.2008-05-05Not applicableUs
Ropinirole Hydrochloridetablet, film coated1 mg/1oralMajor Pharmaceuticals2014-10-01Not applicableUs
Ropinirole Hydrochloridetablet, film coated4 mg/1oralWockhardt Limited2008-05-29Not applicableUs
Ropinirole Hydrochloridetablet, film coated5 mg/1oralbryant ranch prepack2011-09-20Not applicableUs
Ropinirole Hydrochloridetablet, film coated3 mg/1oralWockhardt USA LLC.2008-05-29Not applicableUs
Ropinirole Hydrochloridetablet, film coated.25 mg/1oralAmerican Health Packaging2014-01-20Not applicableUs
Ropinirole Hydrochloridetablet, film coated5 mg/1oralZydus Pharmaceuticals (USA) Inc.2009-09-23Not applicableUs
Ropinirole Hydrochloridetablet, film coated3 mg/1oralAlembic Pharmaceuticals Inc.2016-01-29Not applicableUs
Ropinirole Hydrochloridetablet.5 mg/1oralMylan Pharmaceuticals Inc.2008-05-05Not applicableUs
Ropinirole Hydrochloridetablet1 mg/1oralSTAT Rx USA LLC2009-09-17Not applicableUs
Ropinirole Hydrochloridetablet, film coated, extended release4 mg/1oralAv Kare, Inc.2013-09-13Not applicableUs
Ropinirole Hydrochloridetablet, film coated, extended release6 mg/1oralWockhardt Limited2012-08-15Not applicableUs
Ropinirole Hydrochloridetablet, film coated1 mg/1oralZhejiang Huahai Pharmaceutical Co., Ltd.2011-08-10Not applicableUs
Ropinirole Hydrochloridetablet, film coated, extended release12 mg/1oralWockhardt USA LLC.2012-08-15Not applicableUs
Ropinirole Hydrochloridetablet, film coated.5 mg/1oralAlembic Pharmaceuticals Limited2013-09-12Not applicableUs
Ropinirole Hydrochloridetablet, film coated, extended release6 mg/1oralMylan Pharmaceuticals Inc.2012-10-16Not applicableUs
Ropinirole Hydrochloridetablet.25 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-10-27Not applicableUs
Ropinirole Hydrochloridetablet, film coated.5 mg/1oralWockhardt USA LLC.2008-05-29Not applicableUs
Ropinirole Hydrochloridetablet, film coated3 mg/1oralCadila Healthcare Limited2009-09-23Not applicableUs
Ropinirole Hydrochloridetablet, film coated2 mg/1oralZydus Pharmaceuticals (USA) Inc.2009-09-23Not applicableUs
Ropinirole Hydrochloridetablet, film coated2 mg/1oralAmerican Health Packaging2013-07-052016-01-05Us
Ropinirole Hydrochloridetablet, film coated.5 mg/1oralAlembic Pharmaceuticals Inc.2016-01-29Not applicableUs
Ropinirole Hydrochloridetablet, film coated.25 mg/1oralAidarex Pharmaceuticals LLC2009-09-18Not applicableUs
Ropinirole Hydrochloridetablet, film coated1 mg/1oralWockhardt Limited2008-05-29Not applicableUs
Ropinirole Hydrochloridetablet, film coated4 mg/1oralMajor Pharmaceuticals2009-07-08Not applicableUs
Ropinirole Hydrochloridetablet1 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-10-27Not applicableUs
Ropinirole Hydrochloridetablet, film coated, extended release12 mg/1oralMylan Pharmaceuticals Inc.2012-10-16Not applicableUs
Ropinirole Hydrochloridetablet, film coated.25 mg/1oralMajor Pharmaceuticals2014-10-01Not applicableUs
Ropinirole Hydrochloridetablet, film coated3 mg/1oralWockhardt Limited2008-05-29Not applicableUs
Ropinirole Hydrochloridetablet, film coated1 mg/1oralbryant ranch prepack2009-09-18Not applicableUs
Ropinirole Hydrochloridetablet, film coated2 mg/1oralWockhardt USA LLC.2008-05-29Not applicableUs
Ropinirole Hydrochloridetablet, film coated5 mg/1oralCadila Healthcare Limited2009-09-23Not applicableUs
Ropinirole Hydrochloridetablet, film coated4 mg/1oralZydus Pharmaceuticals (USA) Inc.2009-09-23Not applicableUs
Ropinirole Hydrochloridetablet, film coated2 mg/1oralAlembic Pharmaceuticals Inc.2016-01-29Not applicableUs
Ropinirole Hydrochloridetablet, film coated.5 mg/1oralSolco healthcare U.S., LLC2011-09-20Not applicableUs
Ropinirole Hydrochloridetablet, coated2 mg/1oralPhysicians Total Care, Inc.2008-06-27Not applicableUs
Ropinirole Hydrochloridetablet.25 mg/1oralMylan Pharmaceuticals Inc.2008-05-05Not applicableUs
Ropinirole Hydrochloridetablet, film coated, extended release2 mg/1oralAv Kare, Inc.2013-09-13Not applicableUs
Ropinirole Hydrochloridetablet, film coated, extended release12 mg/1oralWockhardt Limited2012-08-15Not applicableUs
Ropinirole Hydrochloridetablet, film coated.5 mg/1oralZhejiang Huahai Pharmaceutical Co., Ltd.2011-08-10Not applicableUs
Ropinirole Hydrochloridetablet, film coated, extended release8 mg/1oralWockhardt USA LLC.2012-08-15Not applicableUs
Ropinirole Hydrochloridetablet, film coated.25 mg/1oralAlembic Pharmaceuticals Limited2013-09-12Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AdartrelNot Available
ReQuip CRGlaxoSmithKline
RonirolNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Ropinirole Hydrochloride
Thumb
  • InChI Key: XDXHAEQXIBQUEZ-UHFFFAOYSA-N
  • Monoisotopic Mass: 296.165541139
  • Average Mass: 296.836
DBSALT000390
Categories
UNII030PYR8953
CAS number91374-21-9
WeightAverage: 260.3746
Monoisotopic: 260.1888634
Chemical FormulaC16H24N2O
InChI KeyInChIKey=UHSKFQJFRQCDBE-UHFFFAOYSA-N
InChI
InChI=1S/C16H24N2O/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15/h5-7H,3-4,8-12H2,1-2H3,(H,17,19)
IUPAC Name
4-[2-(dipropylamino)ethyl]-2,3-dihydro-1H-indol-2-one
SMILES
CCCN(CCC)CCC1=C2CC(=O)NC2=CC=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as indolines. These are compounds containing an indole moiety, which consists of pyrrolidine ring fused to benzene to form 2,3-dihydroindole.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassIndoles and derivatives
Sub ClassIndolines
Direct ParentIndolines
Alternative Parents
Substituents
  • Phenethylamine
  • Dihydroindole
  • Aralkylamine
  • Benzenoid
  • Tertiary aliphatic amine
  • Tertiary amine
  • Secondary carboxylic acid amide
  • Lactam
  • Carboxamide group
  • Azacycle
  • Carboxylic acid derivative
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of the signs and symptoms of idiopathic Parkinson's disease. Also used for the treatment of restless legs syndrome.
PharmacodynamicsRopinirole is a nonergot dopamine agonist with high relative in vitro specificity and full intrinsic activity at the D2 subfamily of dopamine receptors, binding with higher affinity to D3 than to D2 or D4 receptor subtypes. The relevance of D3 receptor binding in Parkinson's disease is unknown. The mechanism of ropinirole-induced postural hypotension is presumed to be due to a D2 -mediated blunting of the noradrenergic response to standing and subsequent decrease in peripheral vascular resistance.
Mechanism of actionRopinirole binds the dopamine receptors D3 and D2. Although the precise mechanism of action of ropinirole as a treatment for Parkinson's disease is unknown, it is believed to be related to its ability to stimulate these receptors in the striatum. This conclusion is supported by electrophysiologic studies in animals that have demonstrated that ropinirole influences striatal neuronal firing rates via activation of dopamine receptors in the striatum and the substantia nigra, the site of neurons that send projections to the striatum.
Related Articles
AbsorptionAbsolute bioavailability is 55%, indicating a first pass effect. Food does not affect the extent of absorption.
Volume of distribution
  • 7.5 L/kg
  • 525 L
Protein binding40% bound to plasma proteins with a blood-to-plasma ratio of 1:1.
Metabolism

Hepatic. Ropinirole is extensively metabolized to inactive metabolites via N -despropylation and hydroxylation pathways, largely by the P450 isoenzyme CYP1A2. N-despropyl ropinirole is the predominant metabolite found in urine (40%), followed by the carboxylic acid metabolite (10%), and the glucuronide of the hydroxy metabolite (10%).

SubstrateEnzymesProduct
Ropinirole
Not Available
N-despropyl ropiniroleDetails
Route of eliminationRopinirole is extensively metabolized by the liver to inactive metabolites, and less than 10% of the administered dose is excreted as unchanged drug in urine.
Half life6 hours
Clearance
  • 47 L/hr [after oral administration to Parkinson’s disease patients and patients with Restless Legs Syndrome]
ToxicitySymptoms of overdose include agitation, chest pain, confusion, drowsiness, facial muscle movements, grogginess, increased jerkiness of movement, symptoms of low blood pressure (dizziness, light-headedness)upon standing, nausea, and vomiting.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.9971
Caco-2 permeable+0.6087
P-glycoprotein substrateSubstrate0.7604
P-glycoprotein inhibitor IInhibitor0.5458
P-glycoprotein inhibitor IINon-inhibitor0.8641
Renal organic cation transporterNon-inhibitor0.602
CYP450 2C9 substrateNon-substrate0.8593
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.6903
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorInhibitor0.8932
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.8309
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.6959
Ames testNon AMES toxic0.7302
CarcinogenicityNon-carcinogens0.905
BiodegradationNot ready biodegradable0.9966
Rat acute toxicity2.6400 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8959
hERG inhibition (predictor II)Non-inhibitor0.7066
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Smithkline beecham corp dba glaxosmithkline
  • Glaxosmithkline
  • Alembic ltd
  • Corepharma llc
  • Glenmark generics ltd
  • Huahai us inc
  • Mylan pharmaceuticals inc
  • Roxane laboratories inc
  • Teva pharmaceuticals usa inc
  • Wockhardt ltd
  • Zydus pharmaceuticals usa inc
Packagers
Dosage forms
FormRouteStrength
Tabletoral3.0 mg
Tabletoral4.0 mg
Tabletoral0.5 mg
Tabletoral1.0 mg
Tabletoral2.0 mg
Tabletoral5.0 mg
Tabletoral0.25 mg
Tabletoral1 mg
Tabletoral2 mg
Tabletoral5 mg
Tablet, film coatedoral.25 mg/1
Tablet, film coatedoral.5 mg/1
Tablet, film coatedoral1 mg/1
Tablet, film coatedoral2 mg/1
Tablet, film coatedoral3 mg/1
Tablet, film coatedoral4 mg/1
Tablet, film coatedoral5 mg/1
Tablet, film coated, extended releaseoral12 mg/1
Tablet, film coated, extended releaseoral2 mg/1
Tablet, film coated, extended releaseoral4 mg/1
Tablet, film coated, extended releaseoral6 mg/1
Tablet, film coated, extended releaseoral8 mg/1
Tabletoral.25 mg/1
Tabletoral.5 mg/1
Tabletoral1 mg/1
Tabletoral2 mg/1
Tabletoral3 mg/1
Tabletoral4 mg/1
Tabletoral5 mg/1
Tablet, coatedoral.25 mg/1
Tablet, coatedoral.5 mg/1
Tablet, coatedoral1 mg/1
Tablet, coatedoral2 mg/1
Tablet, coatedoral4 mg/1
Tablet, coatedoral5 mg/1
Tablet, film coatedoral; oral2 mg/1
Prices
Unit descriptionCostUnit
Requip XL 12 mg 24 Hour tablet14.92USD tablet
Requip xl 12 mg tablet14.35USD tablet
Requip XL 8 mg 24 Hour tablet8.96USD tablet
Requip xl 6 mg tablet8.61USD tablet
Requip xl 8 mg tablet8.61USD tablet
Requip XL 4 mg 24 Hour tablet5.97USD tablet
Requip xl 4 mg tablet5.74USD tablet
Requip 5 mg Tablet3.87USD tablet
Requip 3 mg tablet3.41USD tablet
Requip 4 mg tablet3.41USD tablet
Requip 5 mg tablet3.41USD tablet
Requip 0.25 mg tablet3.29USD tablet
Requip 0.5 mg tablet3.29USD tablet
Requip 1 mg tablet3.29USD tablet
Requip 2 mg tablet3.29USD tablet
Requip xl 2 mg tablet2.87USD tablet
Ropinirole hcl 3 mg tablet2.65USD tablet
Ropinirole hcl 4 mg tablet2.65USD tablet
Ropinirole hcl 5 mg tablet2.65USD tablet
Ropinirole hcl 0.25 mg tablet2.55USD tablet
Ropinirole hcl 0.5 mg tablet2.55USD tablet
Ropinirole hcl 1 mg tablet2.55USD tablet
Ropinirole hcl 2 mg tablet2.55USD tablet
Co Ropinirole 5 mg Tablet1.8USD tablet
Pms-Ropinirole 5 mg Tablet1.8USD tablet
Ran-Ropinirole 5 mg Tablet1.8USD tablet
Ropinirole 5 mg Tablet1.8USD tablet
Requip 2 mg Tablet1.41USD tablet
Requip 1 mg Tablet1.28USD tablet
Co Ropinirole 2 mg Tablet0.65USD tablet
Pms-Ropinirole 2 mg Tablet0.65USD tablet
Ran-Ropinirole 2 mg Tablet0.65USD tablet
Ropinirole 2 mg Tablet0.65USD tablet
Co Ropinirole 1 mg Tablet0.59USD tablet
Pms-Ropinirole 1 mg Tablet0.59USD tablet
Ran-Ropinirole 1 mg Tablet0.59USD tablet
Ropinirole 1 mg Tablet0.59USD tablet
Requip 0.25 mg Tablet0.32USD tablet
Co Ropinirole 0.25 mg Tablet0.15USD tablet
Pms-Ropinirole 0.25 mg Tablet0.15USD tablet
Ran-Ropinirole 0.25 mg Tablet0.15USD tablet
Ropinirole 0.25 mg Tablet0.15USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5422123 No1995-06-062012-06-06Us
US7927624 No2001-12-022021-12-02Us
US8303986 No2001-04-122021-04-12Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point243-250 °CNot Available
water solubility133 mg/mLNot Available
logP2.70ADLARD,M ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility0.353 mg/mLALOGPS
logP3.16ALOGPS
logP3.06ChemAxon
logS-2.9ALOGPS
pKa (Strongest Acidic)13.24ChemAxon
pKa (Strongest Basic)10.17ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area32.34 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity81.43 m3·mol-1ChemAxon
Polarizability31.19 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-03di-0190000000-7e072cf65f341641938cView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-03di-3960000000-47d2311adfeeacf4062dView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0006-7900000000-0891c66db163729a5360View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0a4i-0090000000-88c0fa3d93090a0d06c6View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0pb9-3590000000-8fb5fc766313ee6bbd9eView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0k96-9400000000-f1b50dacd59a9bfe90b7View in MoNA
References
Synthesis Reference

DrugSyn.org

US4452808
General ReferencesNot Available
External Links
ATC CodesN04BC04
AHFS Codes
  • 28:36.20.08
PDB EntriesNot Available
FDA labelDownload (267 KB)
MSDSDownload (29.6 KB)
Interactions
Drug Interactions
Drug
AbirateroneThe serum concentration of Ropinirole can be increased when it is combined with Abiraterone.
AlfentanilAlfentanil may increase the sedative activities of Ropinirole.
AlprazolamAlprazolam may increase the sedative activities of Ropinirole.
AmisulprideThe therapeutic efficacy of Amisulpride can be decreased when used in combination with Ropinirole.
AmitriptylineAmitriptyline may increase the sedative activities of Ropinirole.
AmobarbitalAmobarbital may increase the sedative activities of Ropinirole.
AmoxapineAmoxapine may increase the sedative activities of Ropinirole.
AzelastineAzelastine may increase the sedative activities of Ropinirole.
BaclofenBaclofen may increase the sedative activities of Ropinirole.
BortezomibThe metabolism of Ropinirole can be decreased when combined with Bortezomib.
BrimonidineBrimonidine may increase the sedative activities of Ropinirole.
BromazepamBromazepam may increase the sedative activities of Ropinirole.
BrompheniramineBrompheniramine may increase the sedative activities of Ropinirole.
BuprenorphineBuprenorphine may increase the sedative activities of Ropinirole.
BupropionThe risk or severity of adverse effects can be increased when Ropinirole is combined with Bupropion.
BuspironeBuspirone may increase the sedative activities of Ropinirole.
ButabarbitalButabarbital may increase the sedative activities of Ropinirole.
ButorphanolButorphanol may increase the sedative activities of Ropinirole.
CarbamazepineThe metabolism of Ropinirole can be increased when combined with Carbamazepine.
CarbinoxamineCarbinoxamine may increase the sedative activities of Ropinirole.
CarisoprodolCarisoprodol may increase the sedative activities of Ropinirole.
CetirizineCetirizine may increase the sedative activities of Ropinirole.
ChlordiazepoxideChlordiazepoxide may increase the sedative activities of Ropinirole.
ChlorotrianiseneThe serum concentration of Ropinirole can be increased when it is combined with Chlorotrianisene.
ChlorphenamineChlorphenamine may increase the sedative activities of Ropinirole.
ChlorzoxazoneChlorzoxazone may increase the sedative activities of Ropinirole.
CiprofloxacinThe serum concentration of Ropinirole can be increased when it is combined with Ciprofloxacin.
ClemastineClemastine may increase the sedative activities of Ropinirole.
ClobazamClobazam may increase the sedative activities of Ropinirole.
ClomipramineClomipramine may increase the sedative activities of Ropinirole.
ClonazepamClonazepam may increase the sedative activities of Ropinirole.
ClonidineClonidine may increase the sedative activities of Ropinirole.
ClorazepateClorazepate may increase the sedative activities of Ropinirole.
CyclizineCyclizine may increase the sedative activities of Ropinirole.
CyclobenzaprineCyclobenzaprine may increase the sedative activities of Ropinirole.
CyproheptadineCyproheptadine may increase the sedative activities of Ropinirole.
Cyproterone acetateThe serum concentration of Ropinirole can be decreased when it is combined with Cyproterone acetate.
DantroleneDantrolene may increase the sedative activities of Ropinirole.
DeferasiroxThe serum concentration of Ropinirole can be increased when it is combined with Deferasirox.
DesfluraneDesflurane may increase the sedative activities of Ropinirole.
DesipramineDesipramine may increase the sedative activities of Ropinirole.
DesloratadineDesloratadine may increase the sedative activities of Ropinirole.
Dexchlorpheniramine maleateDexchlorpheniramine maleate may increase the sedative activities of Ropinirole.
DiazepamDiazepam may increase the sedative activities of Ropinirole.
DimenhydrinateDimenhydrinate may increase the sedative activities of Ropinirole.
DiphenhydramineDiphenhydramine may increase the sedative activities of Ropinirole.
DoxepinDoxepin may increase the sedative activities of Ropinirole.
DoxylamineDoxylamine may increase the sedative activities of Ropinirole.
EfavirenzEfavirenz may increase the sedative activities of Ropinirole.
EntacaponeEntacapone may increase the sedative activities of Ropinirole.
EstazolamEstazolam may increase the sedative activities of Ropinirole.
EstradiolThe serum concentration of Ropinirole can be increased when it is combined with Estradiol.
Estrone sulfateThe serum concentration of Ropinirole can be increased when it is combined with Estropipate.
EszopicloneEszopiclone may increase the sedative activities of Ropinirole.
EthanolEthanol may increase the sedative activities of Ropinirole.
EthosuximideEthosuximide may increase the sedative activities of Ropinirole.
EthotoinEthotoin may increase the sedative activities of Ropinirole.
EzogabineEzogabine may increase the sedative activities of Ropinirole.
FelbamateFelbamate may increase the sedative activities of Ropinirole.
FentanylFentanyl may increase the sedative activities of Ropinirole.
FexofenadineFexofenadine may increase the sedative activities of Ropinirole.
FlibanserinFlibanserin may increase the sedative activities of Ropinirole.
FlunarizineFlunarizine may increase the sedative activities of Ropinirole.
FlurazepamFlurazepam may increase the sedative activities of Ropinirole.
FluvoxamineThe metabolism of Ropinirole can be decreased when combined with Fluvoxamine.
FosphenytoinFosphenytoin may increase the sedative activities of Ropinirole.
GabapentinGabapentin may increase the sedative activities of Ropinirole.
gabapentin enacarbilgabapentin enacarbil may increase the sedative activities of Ropinirole.
Gamma Hydroxybutyric AcidGamma Hydroxybutyric Acid may increase the sedative activities of Ropinirole.
GuanfacineGuanfacine may increase the sedative activities of Ropinirole.
HydrocodoneHydrocodone may increase the sedative activities of Ropinirole.
HydromorphoneHydromorphone may increase the sedative activities of Ropinirole.
HydroxyzineHydroxyzine may increase the sedative activities of Ropinirole.
ImipramineImipramine may increase the sedative activities of Ropinirole.
IsofluraneIsoflurane may increase the sedative activities of Ropinirole.
KetamineKetamine may increase the sedative activities of Ropinirole.
LamotrigineLamotrigine may increase the sedative activities of Ropinirole.
LevetiracetamLevetiracetam may increase the sedative activities of Ropinirole.
LevocabastineLevocabastine may increase the sedative activities of Ropinirole.
LevocetirizineLevocetirizine may increase the sedative activities of Ropinirole.
LevorphanolLevorphanol may increase the sedative activities of Ropinirole.
LoratadineLoratadine may increase the sedative activities of Ropinirole.
LorazepamLorazepam may increase the sedative activities of Ropinirole.
LoxapineThe therapeutic efficacy of Loxapine can be decreased when used in combination with Ropinirole.
MaprotilineMaprotiline may increase the sedative activities of Ropinirole.
MeclizineMeclizine may increase the sedative activities of Ropinirole.
MeprobamateMeprobamate may increase the sedative activities of Ropinirole.
MetaxaloneMetaxalone may increase the sedative activities of Ropinirole.
MethadoneMethadone may increase the sedative activities of Ropinirole.
MethocarbamolMethocarbamol may increase the sedative activities of Ropinirole.
MethohexitalMethohexital may increase the sedative activities of Ropinirole.
MethsuximideMethsuximide may increase the sedative activities of Ropinirole.
MethylphenidateThe risk or severity of adverse effects can be increased when Methylphenidate is combined with Ropinirole.
MetoclopramideThe therapeutic efficacy of Ropinirole can be decreased when used in combination with Metoclopramide.
MexiletineThe metabolism of Ropinirole can be decreased when combined with Mexiletine.
MidazolamMidazolam may increase the sedative activities of Ropinirole.
MirtazapineMirtazapine may increase the sedative activities of Ropinirole.
MorphineMorphine may increase the sedative activities of Ropinirole.
NalbuphineNalbuphine may increase the sedative activities of Ropinirole.
NitrazepamNitrazepam may increase the sedative activities of Ropinirole.
Nitrous oxideNitrous oxide may increase the sedative activities of Ropinirole.
NortriptylineNortriptyline may increase the sedative activities of Ropinirole.
OlopatadineOlopatadine may increase the sedative activities of Ropinirole.
OrphenadrineOrphenadrine may increase the sedative activities of Ropinirole.
OxazepamOxazepam may increase the sedative activities of Ropinirole.
OxycodoneOxycodone may increase the sedative activities of Ropinirole.
OxymorphoneOxymorphone may increase the sedative activities of Ropinirole.
ParaldehydeParaldehyde may increase the sedative activities of Ropinirole.
Peginterferon alfa-2bThe serum concentration of Ropinirole can be increased when it is combined with Peginterferon alfa-2b.
PentazocinePentazocine may increase the sedative activities of Ropinirole.
PentobarbitalPentobarbital may increase the sedative activities of Ropinirole.
PerampanelPerampanel may increase the sedative activities of Ropinirole.
PethidinePethidine may increase the sedative activities of Ropinirole.
PhenelzinePhenelzine may increase the orthostatic hypotensive activities of Ropinirole.
PhenytoinPhenytoin may increase the sedative activities of Ropinirole.
PipotiazinePipotiazine may increase the sedative activities of Ropinirole.
PizotifenPizotifen may increase the sedative activities of Ropinirole.
PomalidomidePomalidomide may increase the sedative activities of Ropinirole.
PregabalinPregabalin may increase the sedative activities of Ropinirole.
PromethazinePromethazine may increase the sedative activities of Ropinirole.
PropofolPropofol may increase the sedative activities of Ropinirole.
ProtriptylineProtriptyline may increase the sedative activities of Ropinirole.
QuazepamQuazepam may increase the sedative activities of Ropinirole.
RamelteonRamelteon may increase the sedative activities of Ropinirole.
RemifentanilRemifentanil may increase the sedative activities of Ropinirole.
ReserpineReserpine may increase the sedative activities of Ropinirole.
ScopolamineScopolamine may increase the sedative activities of Ropinirole.
Scopolamine butylbromideScopolamine butylbromide may increase the sedative activities of Ropinirole.
SecobarbitalSecobarbital may increase the sedative activities of Ropinirole.
SevofluraneSevoflurane may increase the sedative activities of Ropinirole.
Sodium oxybateSodium oxybate may increase the sedative activities of Ropinirole.
SufentanilSufentanil may increase the sedative activities of Ropinirole.
SulpirideThe therapeutic efficacy of Sulpiride can be decreased when used in combination with Ropinirole.
SuvorexantSuvorexant may increase the sedative activities of Ropinirole.
TapentadolTapentadol may increase the sedative activities of Ropinirole.
TasimelteonTasimelteon may increase the sedative activities of Ropinirole.
TemazepamTemazepam may increase the sedative activities of Ropinirole.
TeriflunomideThe serum concentration of Ropinirole can be decreased when it is combined with Teriflunomide.
TetrabenazineTetrabenazine may increase the sedative activities of Ropinirole.
ThalidomideThalidomide may increase the sedative activities of Ropinirole.
TiagabineTiagabine may increase the sedative activities of Ropinirole.
TizanidineThe serum concentration of Tizanidine can be increased when it is combined with Ropinirole.
TolcaponeTolcapone may increase the sedative activities of Ropinirole.
TopiramateTopiramate may increase the sedative activities of Ropinirole.
TramadolTramadol may increase the sedative activities of Ropinirole.
TranylcypromineTranylcypromine may increase the orthostatic hypotensive activities of Ropinirole.
TriazolamTriazolam may increase the sedative activities of Ropinirole.
TrimipramineTrimipramine may increase the sedative activities of Ropinirole.
TriprolidineTriprolidine may increase the sedative activities of Ropinirole.
VemurafenibThe serum concentration of Ropinirole can be increased when it is combined with Vemurafenib.
VigabatrinVigabatrin may increase the sedative activities of Ropinirole.
ZaleplonZaleplon may increase the sedative activities of Ropinirole.
ZiconotideZiconotide may increase the sedative activities of Ropinirole.
ZiprasidoneThe therapeutic efficacy of Ropinirole can be decreased when used in combination with Ziprasidone.
ZolpidemZolpidem may increase the sedative activities of Ropinirole.
ZonisamideZonisamide may increase the sedative activities of Ropinirole.
ZopicloneZopiclone may increase the sedative activities of Ropinirole.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
G-protein coupled amine receptor activity
Specific Function:
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
Gene Name:
DRD3
Uniprot ID:
P35462
Molecular Weight:
44224.335 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. [PubMed:18691132 ]
  3. Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. [PubMed:10641988 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Potassium channel regulator activity
Specific Function:
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.
Gene Name:
DRD2
Uniprot ID:
P14416
Molecular Weight:
50618.91 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. de Mey C, Enterling D, Meineke I, Yeulet S: Interactions between domperidone and ropinirole, a novel dopamine D2-receptor agonist. Br J Clin Pharmacol. 1991 Oct;32(4):483-8. [PubMed:1683559 ]
  3. Iida M, Miyazaki I, Tanaka K, Kabuto H, Iwata-Ichikawa E, Ogawa N: Dopamine D2 receptor-mediated antioxidant and neuroprotective effects of ropinirole, a dopamine agonist. Brain Res. 1999 Aug 14;838(1-2):51-9. [PubMed:10446316 ]
  4. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. [PubMed:18691132 ]
  5. Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. [PubMed:10641988 ]
  6. Matsukawa N, Maki M, Yasuhara T, Hara K, Yu G, Xu L, Kim KM, Morgan JC, Sethi KD, Borlongan CV: Overexpression of D2/D3 receptors increases efficacy of ropinirole in chronically 6-OHDA-lesioned Parkinsonian rats. Brain Res. 2007 Jul 30;1160:113-23. Epub 2007 May 26. [PubMed:17573046 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Sh3 domain binding
Specific Function:
Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).
Gene Name:
DRD4
Uniprot ID:
P21917
Molecular Weight:
48359.86 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. [PubMed:18691132 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Serotonin receptor activity
Specific Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G pro...
Gene Name:
HTR1A
Uniprot ID:
P08908
Molecular Weight:
46106.335 Da
References
  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. [PubMed:18691132 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Serotonin receptor activity
Specific Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate c...
Gene Name:
HTR1D
Uniprot ID:
P28221
Molecular Weight:
41906.38 Da
References
  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. [PubMed:18691132 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Serotonin receptor activity
Specific Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins ...
Gene Name:
HTR2B
Uniprot ID:
P41595
Molecular Weight:
54297.41 Da
References
  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. [PubMed:18691132 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
G-protein coupled amine receptor activity
Specific Function:
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
Gene Name:
DRD1
Uniprot ID:
P21728
Molecular Weight:
49292.765 Da
References
  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. [PubMed:18691132 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
G-protein coupled amine receptor activity
Specific Function:
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
Gene Name:
DRD5
Uniprot ID:
P21918
Molecular Weight:
52950.5 Da
References
  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. [PubMed:18691132 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Serotonin receptor activity
Specific Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of ...
Gene Name:
HTR1B
Uniprot ID:
P28222
Molecular Weight:
43567.535 Da
References
  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. [PubMed:18691132 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Virus receptor activity
Specific Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates...
Gene Name:
HTR2A
Uniprot ID:
P28223
Molecular Weight:
52602.58 Da
References
  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. [PubMed:18691132 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Serotonin receptor activity
Specific Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modul...
Gene Name:
HTR2C
Uniprot ID:
P28335
Molecular Weight:
51820.705 Da
References
  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. [PubMed:18691132 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Thioesterase binding
Specific Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianser...
Gene Name:
ADRA2A
Uniprot ID:
P08913
Molecular Weight:
48956.275 Da
References
  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. [PubMed:18691132 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Epinephrine binding
Specific Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phent...
Gene Name:
ADRA2B
Uniprot ID:
P18089
Molecular Weight:
49565.8 Da
References
  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. [PubMed:18691132 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Protein homodimerization activity
Specific Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
Gene Name:
ADRA2C
Uniprot ID:
P18825
Molecular Weight:
49521.585 Da
References
  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. [PubMed:18691132 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. [PubMed:18691132 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. [PubMed:18691132 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. [PubMed:18691132 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
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Drug created on June 13, 2005 07:24 / Updated on July 24, 2016 01:51