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Identification
NameRopinirole
Accession NumberDB00268  (APRD00302)
TypeSmall Molecule
GroupsApproved, Investigational
Description

Ropinirole is a non-ergoline dopamine agonist, manufactured by GlaxoSmithKline. It is used in the treatment of Parkinson’s disease, and is also one of two medications in the United States with an FDA-approved indication for the treatment of restless legs syndrome (the other being Pramipexole). [Wikipedia]

Structure
Thumb
Synonyms
SynonymLanguageCode
RopinirolSpanishINN
RopiniroleNot AvailableNot Available
RopinirolumLatinINN
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Requip XLtablet, film coated, extended release12 mgoralGlaxo Smith Kline Llc2008-11-20Not AvailableUs
Requip XLtablet, film coated, extended release6 mgoralGlaxo Smith Kline Llc2009-08-03Not AvailableUs
Requip XLtablet, film coated, extended release2 mgoralGlaxo Smith Kline Llc2008-06-30Not AvailableUs
Requip XLtablet, film coated, extended release4 mgoralGlaxo Smith Kline Llc2008-06-30Not AvailableUs
Requip XLtablet, film coated, extended release8 mgoralGlaxo Smith Kline Llc2008-06-30Not AvailableUs
Requiptablet, film coated.25 mgoralGlaxo Smith Kline Llc1997-10-10Not AvailableUs
Requiptablet, film coated.5 mgoralGlaxo Smith Kline Llc1997-10-10Not AvailableUs
Requiptablet, film coated1 mgoralGlaxo Smith Kline Llc1997-10-01Not AvailableUs
Requiptablet, film coated2 mgoralGlaxo Smith Kline Llc1997-10-03Not AvailableUs
Requiptablet, film coated5 mgoralGlaxo Smith Kline Llc1997-10-10Not AvailableUs
Requiptablet, film coated3 mgoralGlaxo Smith Kline Llc2001-06-19Not AvailableUs
Requiptablet, film coated4 mgoralGlaxo Smith Kline Llc1999-09-21Not AvailableUs
Requip XLtablet, film coated, extended release2 mgoralPhysicians Total Care, Inc.2009-12-18Not AvailableUs
Requiptablet, film coated1 mgoralPd Rx Pharmaceuticals, Inc.1997-10-01Not AvailableUs
Requiptablet, film coated1 mgoralbryant ranch prepack1997-10-01Not AvailableUs
Requiptablet0.25 mgoralGlaxosmithkline IncNot AvailableNot AvailableCanada
Requiptablet1 mgoralGlaxosmithkline IncNot AvailableNot AvailableCanada
Requiptablet2 mgoralGlaxosmithkline IncNot AvailableNot AvailableCanada
Requiptablet5 mgoralGlaxosmithkline IncNot AvailableNot AvailableCanada
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ropiniroletablet.25 mgoralRoxane Laboratories, Inc2008-05-05Not AvailableUs
Ropiniroletablet.5 mgoralRoxane Laboratories, Inc2008-05-05Not AvailableUs
Ropiniroletablet1 mgoralRoxane Laboratories, Inc2008-05-05Not AvailableUs
Ropiniroletablet2 mgoralRoxane Laboratories, Inc2008-05-05Not AvailableUs
Ropiniroletablet3 mgoralRoxane Laboratories, Inc2008-05-05Not AvailableUs
Ropiniroletablet4 mgoralRoxane Laboratories, Inc2008-05-05Not AvailableUs
Ropiniroletablet5 mgoralRoxane Laboratories, Inc2008-05-05Not AvailableUs
Ropiniroletablet, film coated, extended release6 mgoralActavis Elizabeh LLC2012-05-18Not AvailableUs
Ropiniroletablet, film coated, extended release2 mgoralActavis Elizabeh LLC2012-05-18Not AvailableUs
Ropiniroletablet, film coated, extended release4 mgoralActavis Elizabeh LLC2012-05-18Not AvailableUs
Ropiniroletablet, film coated, extended release8 mgoralActavis Elizabeh LLC2012-05-18Not AvailableUs
Ropiniroletablet, film coated, extended release12 mgoralActavis Elizabeh LLC2012-05-18Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release2 mgoralMylan Pharmaceuticals Inc.2012-10-16Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release4 mgoralMylan Pharmaceuticals Inc.2012-10-16Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release6 mgoralMylan Pharmaceuticals Inc.2012-10-16Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release8 mgoralMylan Pharmaceuticals Inc.2012-10-16Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release12 mgoralMylan Pharmaceuticals Inc.2012-10-16Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release3 mgoralMylan Pharmaceuticals Inc.2012-10-16Not AvailableUs
Ropinirole Hydrochloridetablet1 mgoralMylan Pharmaceuticals Inc.2008-05-05Not AvailableUs
Ropinirole Hydrochloridetablet2 mgoralMylan Pharmaceuticals Inc.2008-05-05Not AvailableUs
Ropinirole Hydrochloridetablet3 mgoralMylan Pharmaceuticals Inc.2008-05-05Not AvailableUs
Ropinirole Hydrochloridetablet4 mgoralMylan Pharmaceuticals Inc.2008-05-05Not AvailableUs
Ropinirole Hydrochloridetablet5 mgoralMylan Pharmaceuticals Inc.2008-05-05Not AvailableUs
Ropinirole Hydrochloridetablet.25 mgoralMylan Pharmaceuticals Inc.2008-05-05Not AvailableUs
Ropinirole Hydrochloridetablet.5 mgoralMylan Pharmaceuticals Inc.2008-05-05Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release2 mgoralWatson Laboratories, Inc.2012-06-06Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release12 mgoralWatson Laboratories, Inc.2012-06-06Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release4 mgoralWatson Laboratories, Inc.2012-06-06Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release8 mgoralWatson Laboratories, Inc.2012-06-06Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release6 mgoralWatson Laboratories, Inc.2012-06-06Not AvailableUs
Ropinirole Hydrochloridetablet.25 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-10-27Not AvailableUs
Ropinirole Hydrochloridetablet.5 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-10-27Not AvailableUs
Ropinirole Hydrochloridetablet1 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-10-27Not AvailableUs
Ropinirole Hydrochloridetablet2 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-10-27Not AvailableUs
Ropinirole Hydrochloridetablet3 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-10-27Not AvailableUs
Ropiniroletablet, film coated, extended release2 mgoralSandoz Inc2012-06-06Not AvailableUs
Ropiniroletablet, film coated, extended release4 mgoralSandoz Inc2012-06-06Not AvailableUs
Ropiniroletablet, film coated, extended release6 mgoralSandoz Inc2012-06-06Not AvailableUs
Ropiniroletablet, film coated, extended release8 mgoralSandoz Inc2012-06-06Not AvailableUs
Ropiniroletablet, film coated, extended release12 mgoralSandoz Inc2012-06-06Not AvailableUs
Ropinirole Hydrochloridetablet, film coated.25 mgoralMajor Pharmaceuticals2009-07-08Not AvailableUs
Ropinirole Hydrochloridetablet, film coated.5 mgoralMajor Pharmaceuticals2009-07-08Not AvailableUs
Ropinirole Hydrochloridetablet, film coated1 mgoralMajor Pharmaceuticals2009-07-08Not AvailableUs
Ropinirole Hydrochloridetablet, film coated2 mgoral; oralMajor Pharmaceuticals2009-07-08Not AvailableUs
Ropinirole Hydrochloridetablet, film coated3 mgoralMajor Pharmaceuticals2009-07-08Not AvailableUs
Ropinirole Hydrochloridetablet, film coated4 mgoralMajor Pharmaceuticals2009-07-08Not AvailableUs
Ropinirole Hydrochloridetablet, film coated5 mgoralMajor Pharmaceuticals2009-07-08Not AvailableUs
Ropinirole Hydrochloridetablet, film coated.25 mgoralMajor Pharmaceuticals2014-10-01Not AvailableUs
Ropinirole Hydrochloridetablet, film coated1 mgoralMajor Pharmaceuticals2014-10-01Not AvailableUs
Ropinirole 2 mgtablet, film coated, extended release2 mgoralTrigen Laboratories, Inc.2013-06-15Not AvailableUs
Ropinirole 4 mgtablet, film coated, extended release4 mgoralTrigen Laboratories, Inc.2013-06-15Not AvailableUs
Ropinirole 6 mgtablet, film coated, extended release6 mgoralTrigen Laboratories, Inc.2013-06-15Not AvailableUs
Ropinirole 8 mgtablet, film coated, extended release8 mgoralTrigen Laboratories, Inc.2013-06-15Not AvailableUs
Ropinirole 12 mgtablet, film coated, extended release12 mgoralTrigen Laboratories, Inc.2013-06-15Not AvailableUs
Ropinirole Hydrochloridetablet1 mgoralSTAT Rx USA LLC2009-09-17Not AvailableUs
Ropinirole Hydrochloridetablet2 mgoralSTAT Rx USA LLC2009-09-17Not AvailableUs
Ropinirole Hydrochloridetablet, coated.25 mgoralRebel Distributors Corp2008-05-21Not AvailableUs
Ropinirole Hydrochloridetablet, film coated.5 mgoralRebel Distributors Corp2009-09-18Not AvailableUs
Ropinirole Hydrochloridetablet, coated1 mgoralRebel Distributors Corp2008-05-21Not AvailableUs
Ropinirole Hydrochloridetablet, coated5 mgoralRebel Distributors Corp2008-05-21Not AvailableUs
Ropinirole Hydrochloridetablet, film coated.25 mgoralHeritage Pharmaceuticals Inc.2009-09-18Not AvailableUs
Ropinirole Hydrochloridetablet, film coated.5 mgoralHeritage Pharmaceuticals Inc.2009-09-18Not AvailableUs
Ropinirole Hydrochloridetablet, film coated1 mgoralHeritage Pharmaceuticals Inc.2009-09-18Not AvailableUs
Ropinirole Hydrochloridetablet, film coated2 mgoralHeritage Pharmaceuticals Inc.2009-09-18Not AvailableUs
Ropinirole Hydrochloridetablet, film coated3 mgoralHeritage Pharmaceuticals Inc.2009-09-18Not AvailableUs
Ropinirole Hydrochloridetablet, film coated4 mgoralHeritage Pharmaceuticals Inc.2009-10-09Not AvailableUs
Ropinirole Hydrochloridetablet, film coated5 mgoralHeritage Pharmaceuticals Inc.2009-09-18Not AvailableUs
Ropiniroletablet, film coated1 mgoralLake Erie Medical DBA Quality Care Products LLC2010-02-25Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release2 mgoralAv Kare, Inc.2012-06-28Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release4 mgoralAv Kare, Inc.2012-06-28Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release6 mgoralAv Kare, Inc.2012-06-28Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release8 mgoralAv Kare, Inc.2012-06-28Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release12 mgoralAv Kare, Inc.2012-06-28Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release2 mgoralAv Kare, Inc.2013-09-13Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release4 mgoralAv Kare, Inc.2013-09-13Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release6 mgoralAv Kare, Inc.2013-09-13Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release8 mgoralAv Kare, Inc.2013-09-13Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release12 mgoralAv Kare, Inc.2013-09-13Not AvailableUs
Ropiniroletablet2 mgoralAphena Pharma Solutions Tennessee, Llc2008-05-05Not AvailableUs
Ropiniroletablet1 mgoralAphena Pharma Solutions Tennessee, Llc2008-05-05Not AvailableUs
Ropiniroletablet.25 mgoralAphena Pharma Solutions Tennessee, Llc2008-05-05Not AvailableUs
Ropinirole Hydrochloridetablet, film coated.25 mgoralSolco healthcare U.S., LLC2011-09-20Not AvailableUs
Ropinirole Hydrochloridetablet, film coated.5 mgoralSolco healthcare U.S., LLC2011-09-20Not AvailableUs
Ropinirole Hydrochloridetablet, film coated1 mgoralSolco healthcare U.S., LLC2011-09-20Not AvailableUs
Ropinirole Hydrochloridetablet, film coated2 mgoralSolco healthcare U.S., LLC2011-09-20Not AvailableUs
Ropinirole Hydrochloridetablet, film coated3 mgoralSolco healthcare U.S., LLC2011-09-20Not AvailableUs
Ropinirole Hydrochloridetablet, film coated4 mgoralSolco healthcare U.S., LLC2011-09-20Not AvailableUs
Ropinirole Hydrochloridetablet, film coated5 mgoralSolco healthcare U.S., LLC2011-09-20Not AvailableUs
Ropinirole Hydrochloridetablet, film coated.25 mgoralAlembic Pharmaceuticals Limited2013-09-12Not AvailableUs
Ropinirole Hydrochloridetablet, film coated.5 mgoralAlembic Pharmaceuticals Limited2013-09-12Not AvailableUs
Ropinirole Hydrochloridetablet, film coated1 mgoralAlembic Pharmaceuticals Limited2013-09-12Not AvailableUs
Ropinirole Hydrochloridetablet, film coated2 mgoralAlembic Pharmaceuticals Limited2013-09-12Not AvailableUs
Ropinirole Hydrochloridetablet, film coated3 mgoralAlembic Pharmaceuticals Limited2013-09-12Not AvailableUs
Ropinirole Hydrochloridetablet, film coated4 mgoralAlembic Pharmaceuticals Limited2013-09-12Not AvailableUs
Ropinirole Hydrochloridetablet, film coated5 mgoralAlembic Pharmaceuticals Limited2013-09-12Not AvailableUs
Ropinirole Hydrochloridetablet, coated1 mgoralPhysicians Total Care, Inc.2008-05-21Not AvailableUs
Ropinirole Hydrochloridetablet, coated2 mgoralPhysicians Total Care, Inc.2008-06-27Not AvailableUs
Ropinirole Hydrochloridetablet, coated4 mgoralPhysicians Total Care, Inc.2008-07-02Not AvailableUs
Ropinirole Hydrochloridetablet, coated.25 mgoralPhysicians Total Care, Inc.2008-10-22Not AvailableUs
Ropinirole Hydrochloridetablet, coated.5 mgoralPhysicians Total Care, Inc.2008-10-22Not AvailableUs
Ropinirole Hydrochloridetablet, coated5 mgoralPhysicians Total Care, Inc.2010-09-08Not AvailableUs
Ropiniroletablet, film coated, extended release2 mgoralDr. Reddys Laboratories Limited2012-06-06Not AvailableUs
Ropiniroletablet, film coated, extended release4 mgoralDr. Reddys Laboratories Limited2012-06-06Not AvailableUs
Ropiniroletablet, film coated, extended release8 mgoralDr. Reddys Laboratories Limited2012-06-06Not AvailableUs
Ropiniroletablet, film coated, extended release6 mgoralDr. Reddys Laboratories Limited2012-06-06Not AvailableUs
Ropiniroletablet, film coated, extended release12 mgoralDr. Reddys Laboratories Limited2012-06-06Not AvailableUs
Ropinirole Hydrochloridetablet, film coated.25 mgoralWockhardt Limited2008-05-29Not AvailableUs
Ropinirole Hydrochloridetablet, film coated.5 mgoralWockhardt Limited2008-05-29Not AvailableUs
Ropinirole Hydrochloridetablet, film coated1 mgoralWockhardt Limited2008-05-29Not AvailableUs
Ropinirole Hydrochloridetablet, film coated2 mgoralWockhardt Limited2008-05-29Not AvailableUs
Ropinirole Hydrochloridetablet, film coated3 mgoralWockhardt Limited2008-05-29Not AvailableUs
Ropinirole Hydrochloridetablet, film coated4 mgoralWockhardt Limited2008-05-29Not AvailableUs
Ropinirole Hydrochloridetablet, film coated5 mgoralWockhardt Limited2008-05-29Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release2 mgoralWockhardt Limited2012-08-15Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release4 mgoralWockhardt Limited2012-08-15Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release8 mgoralWockhardt Limited2012-08-15Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release12 mgoralWockhardt Limited2012-08-15Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release6 mgoralWockhardt Limited2012-08-15Not AvailableUs
Ropiniroletablet, film coated.25 mgoralApotex Corp.2013-03-29Not AvailableUs
Ropiniroletablet, film coated.5 mgoralApotex Corp.2013-03-29Not AvailableUs
Ropiniroletablet, film coated1 mgoralApotex Corp.2013-03-29Not AvailableUs
Ropiniroletablet, film coated2 mgoralApotex Corp.2013-03-29Not AvailableUs
Ropiniroletablet, film coated3 mgoralApotex Corp.2013-03-29Not AvailableUs
Ropiniroletablet, film coated4 mgoralApotex Corp.2013-03-29Not AvailableUs
Ropiniroletablet, film coated5 mgoralApotex Corp.2013-03-29Not AvailableUs
Ropinirole Hydrochloridetablet, film coated1 mgoralbryant ranch prepack2009-09-18Not AvailableUs
Ropinirole Hydrochloridetablet, film coated5 mgoralbryant ranch prepack2011-09-20Not AvailableUs
Ropinirole Hydrochloridetablet, film coated.5 mgoralbryant ranch prepack2011-09-20Not AvailableUs
Ropinirole Hydrochloridetablet, film coated2 mgoralbryant ranch prepack2009-09-18Not AvailableUs
Ropinirole Hydrochloridetablet, film coated.25 mgoralbryant ranch prepack2009-09-18Not AvailableUs
Ropinirole Hydrochloridetablet, film coated.25 mgoralZhejiang Huahai Pharmaceutical Co., Ltd.2011-08-10Not AvailableUs
Ropinirole Hydrochloridetablet, film coated.5 mgoralZhejiang Huahai Pharmaceutical Co., Ltd.2011-08-10Not AvailableUs
Ropinirole Hydrochloridetablet, film coated1 mgoralZhejiang Huahai Pharmaceutical Co., Ltd.2011-08-10Not AvailableUs
Ropinirole Hydrochloridetablet, film coated2 mgoralZhejiang Huahai Pharmaceutical Co., Ltd.2011-08-10Not AvailableUs
Ropinirole Hydrochloridetablet, film coated3 mgoralZhejiang Huahai Pharmaceutical Co., Ltd.2011-08-10Not AvailableUs
Ropinirole Hydrochloridetablet, film coated4 mgoralZhejiang Huahai Pharmaceutical Co., Ltd.2011-08-10Not AvailableUs
Ropinirole Hydrochloridetablet, film coated5 mgoralZhejiang Huahai Pharmaceutical Co., Ltd.2011-08-10Not AvailableUs
Ropinirole Hydrochloridetablet, film coated.25 mgoralWockhardt USA LLC.2008-05-29Not AvailableUs
Ropinirole Hydrochloridetablet, film coated.5 mgoralWockhardt USA LLC.2008-05-29Not AvailableUs
Ropinirole Hydrochloridetablet, film coated1 mgoralWockhardt USA LLC.2008-05-29Not AvailableUs
Ropinirole Hydrochloridetablet, film coated2 mgoralWockhardt USA LLC.2008-05-29Not AvailableUs
Ropinirole Hydrochloridetablet, film coated3 mgoralWockhardt USA LLC.2008-05-29Not AvailableUs
Ropinirole Hydrochloridetablet, film coated4 mgoralWockhardt USA LLC.2008-05-29Not AvailableUs
Ropinirole Hydrochloridetablet, film coated5 mgoralWockhardt USA LLC.2008-05-29Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release2 mgoralWockhardt USA LLC.2012-08-15Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release4 mgoralWockhardt USA LLC.2012-08-15Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release8 mgoralWockhardt USA LLC.2012-08-15Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release12 mgoralWockhardt USA LLC.2012-08-15Not AvailableUs
Ropinirole Hydrochloridetablet, film coated, extended release6 mgoralWockhardt USA LLC.2012-08-15Not AvailableUs
Ropinirole Hydrochloridetablet, film coated.25 mgoralCadila Healthcare Limited2009-09-23Not AvailableUs
Ropinirole Hydrochloridetablet, film coated.5 mgoralCadila Healthcare Limited2009-09-23Not AvailableUs
Ropinirole Hydrochloridetablet, film coated1 mgoralCadila Healthcare Limited2009-09-23Not AvailableUs
Ropinirole Hydrochloridetablet, film coated2 mgoralCadila Healthcare Limited2009-09-23Not AvailableUs
Ropinirole Hydrochloridetablet, film coated3 mgoralCadila Healthcare Limited2009-09-23Not AvailableUs
Ropinirole Hydrochloridetablet, film coated4 mgoralCadila Healthcare Limited2009-09-23Not AvailableUs
Ropinirole Hydrochloridetablet, film coated5 mgoralCadila Healthcare Limited2009-09-23Not AvailableUs
Ropinirole Hydrochloridetablet, film coated.25 mgoralAmerican Health Packaging2014-01-20Not AvailableUs
Ropinirole Hydrochloridetablet, film coated.5 mgoralAmerican Health Packaging2014-01-20Not AvailableUs
Ropinirole Hydrochloridetablet, film coated.25 mgoralAmerican Health Packaging2013-07-05Not AvailableUs
Ropinirole Hydrochloridetablet, film coated.5 mgoralAmerican Health Packaging2013-07-05Not AvailableUs
Ropinirole Hydrochloridetablet, film coated1 mgoralAmerican Health Packaging2013-07-05Not AvailableUs
Ropinirole Hydrochloridetablet, film coated2 mgoralAmerican Health Packaging2013-07-05Not AvailableUs
Ropinirole Hydrochloridetablet, film coated1 mgoralAmerican Health Packaging2014-01-20Not AvailableUs
Ropinirole Hydrochloridetablet, film coated2 mgoralAmerican Health Packaging2014-01-20Not AvailableUs
Ropiniroletablet.25 mgoralCarilion Materials Management2008-05-05Not AvailableUs
Ropiniroletablet.5 mgoralCarilion Materials Management2008-05-05Not AvailableUs
Ropiniroletablet1 mgoralCarilion Materials Management2008-05-05Not AvailableUs
Ropinirole Hydrochloridetablet, film coated.25 mgoralDispensing Solutions, Inc.2009-09-18Not AvailableUs
Ropiniroletablet, film coated2 mgoralDispensing Solutions, Inc.2010-02-25Not AvailableUs
Ropinirole Hydrochloridetablet, film coated.25 mgoralZydus Pharmaceuticals (USA) Inc.2009-09-23Not AvailableUs
Ropinirole Hydrochloridetablet, film coated.5 mgoralZydus Pharmaceuticals (USA) Inc.2009-09-23Not AvailableUs
Ropinirole Hydrochloridetablet, film coated1 mgoralZydus Pharmaceuticals (USA) Inc.2009-09-23Not AvailableUs
Ropinirole Hydrochloridetablet, film coated2 mgoralZydus Pharmaceuticals (USA) Inc.2009-09-23Not AvailableUs
Ropinirole Hydrochloridetablet, film coated3 mgoralZydus Pharmaceuticals (USA) Inc.2009-09-23Not AvailableUs
Ropinirole Hydrochloridetablet, film coated4 mgoralZydus Pharmaceuticals (USA) Inc.2009-09-23Not AvailableUs
Ropinirole Hydrochloridetablet, film coated5 mgoralZydus Pharmaceuticals (USA) Inc.2009-09-23Not AvailableUs
Ropiniroletablet, film coated.25 mgoralGlenmark Generics Inc., USA2010-02-25Not AvailableUs
Ropiniroletablet, film coated.5 mgoralGlenmark Generics Inc., USA2010-02-25Not AvailableUs
Ropiniroletablet, film coated1 mgoralGlenmark Generics Inc., USA2010-02-25Not AvailableUs
Ropiniroletablet, film coated2 mgoralGlenmark Generics Inc., USA2010-02-25Not AvailableUs
Ropiniroletablet, film coated3 mgoralGlenmark Generics Inc., USA2010-02-25Not AvailableUs
Ropiniroletablet, film coated4 mgoralGlenmark Generics Inc., USA2010-02-25Not AvailableUs
Ropiniroletablet, film coated5 mgoralGlenmark Generics Inc., USA2010-02-25Not AvailableUs
Ropiniroletablet0.25 mgoralSanis Health IncNot AvailableNot AvailableCanada
Ropiniroletablet1 mgoralSanis Health IncNot AvailableNot AvailableCanada
Ropiniroletablet5 mgoralSanis Health IncNot AvailableNot AvailableCanada
Over the Counter ProductsNot Available
International Brands
NameCompany
AdartrelNot Available
ReQuip CRGlaxoSmithKline
RonirolNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Ropinirole Hydrochloride
Thumb
  • InChI Key: XDXHAEQXIBQUEZ-UHFFFAOYSA-N
  • Monoisotopic Mass: 296.165541139
  • Average Mass: 296.836
DBSALT000390
Categories
CAS number91374-21-9
WeightAverage: 260.3746
Monoisotopic: 260.1888634
Chemical FormulaC16H24N2O
InChI KeyUHSKFQJFRQCDBE-UHFFFAOYSA-N
InChI
InChI=1S/C16H24N2O/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15/h5-7H,3-4,8-12H2,1-2H3,(H,17,19)
IUPAC Name
4-[2-(dipropylamino)ethyl]-2,3-dihydro-1H-indol-2-one
SMILES
CCCN(CCC)CCC1=C2CC(=O)NC2=CC=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as indolines. These are compounds containing an indole moiety, which consists of pyrrolidine ring fused to benzene to form 2,3-dihydroindole.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassIndoles and derivatives
Sub ClassIndolines
Direct ParentIndolines
Alternative Parents
Substituents
  • Phenethylamine
  • Dihydroindole
  • Aralkylamine
  • Benzenoid
  • Tertiary aliphatic amine
  • Tertiary amine
  • Secondary carboxylic acid amide
  • Lactam
  • Carboxamide group
  • Azacycle
  • Carboxylic acid derivative
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of the signs and symptoms of idiopathic Parkinson's disease. Also used for the treatment of restless legs syndrome.
PharmacodynamicsRopinirole is a nonergot dopamine agonist with high relative in vitro specificity and full intrinsic activity at the D2 subfamily of dopamine receptors, binding with higher affinity to D3 than to D2 or D4 receptor subtypes. The relevance of D3 receptor binding in Parkinson's disease is unknown. The mechanism of ropinirole-induced postural hypotension is presumed to be due to a D2 -mediated blunting of the noradrenergic response to standing and subsequent decrease in peripheral vascular resistance.
Mechanism of actionRopinirole binds the dopamine receptors D3 and D2. Although the precise mechanism of action of ropinirole as a treatment for Parkinson's disease is unknown, it is believed to be related to its ability to stimulate these receptors in the striatum. This conclusion is supported by electrophysiologic studies in animals that have demonstrated that ropinirole influences striatal neuronal firing rates via activation of dopamine receptors in the striatum and the substantia nigra, the site of neurons that send projections to the striatum.
AbsorptionAbsolute bioavailability is 55%, indicating a first pass effect. Food does not affect the extent of absorption.
Volume of distribution
  • 7.5 L/kg
  • 525 L
Protein binding40% bound to plasma proteins with a blood-to-plasma ratio of 1:1.
Metabolism

Hepatic. Ropinirole is extensively metabolized to inactive metabolites via N -despropylation and hydroxylation pathways, largely by the P450 isoenzyme CYP1A2. N-despropyl ropinirole is the predominant metabolite found in urine (40%), followed by the carboxylic acid metabolite (10%), and the glucuronide of the hydroxy metabolite (10%).

SubstrateEnzymesProduct
Ropinirole
Not Available
N-despropyl ropiniroleDetails
Route of eliminationRopinirole is extensively metabolized by the liver to inactive metabolites, and less than 10% of the administered dose is excreted as unchanged drug in urine.
Half life6 hours
Clearance
  • 47 L/hr [after oral administration to Parkinson’s disease patients and patients with Restless Legs Syndrome]
ToxicitySymptoms of overdose include agitation, chest pain, confusion, drowsiness, facial muscle movements, grogginess, increased jerkiness of movement, symptoms of low blood pressure (dizziness, light-headedness)upon standing, nausea, and vomiting.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.9971
Caco-2 permeable+0.6087
P-glycoprotein substrateSubstrate0.7604
P-glycoprotein inhibitor IInhibitor0.5458
P-glycoprotein inhibitor IINon-inhibitor0.8641
Renal organic cation transporterNon-inhibitor0.602
CYP450 2C9 substrateNon-substrate0.8593
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.6903
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 substrateNon-inhibitor0.9071
CYP450 2D6 substrateInhibitor0.8932
CYP450 2C19 substrateNon-inhibitor0.9025
CYP450 3A4 substrateNon-inhibitor0.8309
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.6959
Ames testNon AMES toxic0.7302
CarcinogenicityNon-carcinogens0.905
BiodegradationNot ready biodegradable0.9966
Rat acute toxicity2.6400 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8959
hERG inhibition (predictor II)Non-inhibitor0.7066
Pharmacoeconomics
Manufacturers
  • Smithkline beecham corp dba glaxosmithkline
  • Glaxosmithkline
  • Alembic ltd
  • Corepharma llc
  • Glenmark generics ltd
  • Huahai us inc
  • Mylan pharmaceuticals inc
  • Roxane laboratories inc
  • Teva pharmaceuticals usa inc
  • Wockhardt ltd
  • Zydus pharmaceuticals usa inc
Packagers
Dosage forms
FormRouteStrength
Tabletoral.25 mg
Tabletoral.5 mg
Tabletoral0.25 mg
Tabletoral1 mg
Tabletoral2 mg
Tabletoral3 mg
Tabletoral4 mg
Tabletoral5 mg
Tablet, coatedoral.25 mg
Tablet, coatedoral.5 mg
Tablet, coatedoral1 mg
Tablet, coatedoral2 mg
Tablet, coatedoral4 mg
Tablet, coatedoral5 mg
Tablet, film coatedoral.25 mg
Tablet, film coatedoral.5 mg
Tablet, film coatedoral1 mg
Tablet, film coatedoral2 mg
Tablet, film coatedoral3 mg
Tablet, film coatedoral4 mg
Tablet, film coatedoral5 mg
Tablet, film coatedoral; oral2 mg
Tablet, film coated, extended releaseoral12 mg
Tablet, film coated, extended releaseoral2 mg
Tablet, film coated, extended releaseoral3 mg
Tablet, film coated, extended releaseoral4 mg
Tablet, film coated, extended releaseoral6 mg
Tablet, film coated, extended releaseoral8 mg
Prices
Unit descriptionCostUnit
Requip XL 12 mg 24 Hour tablet14.92USD tablet
Requip xl 12 mg tablet14.35USD tablet
Requip XL 8 mg 24 Hour tablet8.96USD tablet
Requip xl 6 mg tablet8.61USD tablet
Requip xl 8 mg tablet8.61USD tablet
Requip XL 4 mg 24 Hour tablet5.97USD tablet
Requip xl 4 mg tablet5.74USD tablet
Requip 5 mg Tablet3.87USD tablet
Requip 3 mg tablet3.41USD tablet
Requip 4 mg tablet3.41USD tablet
Requip 5 mg tablet3.41USD tablet
Requip 0.25 mg tablet3.29USD tablet
Requip 0.5 mg tablet3.29USD tablet
Requip 1 mg tablet3.29USD tablet
Requip 2 mg tablet3.29USD tablet
Requip xl 2 mg tablet2.87USD tablet
Ropinirole hcl 3 mg tablet2.65USD tablet
Ropinirole hcl 4 mg tablet2.65USD tablet
Ropinirole hcl 5 mg tablet2.65USD tablet
Ropinirole hcl 0.25 mg tablet2.55USD tablet
Ropinirole hcl 0.5 mg tablet2.55USD tablet
Ropinirole hcl 1 mg tablet2.55USD tablet
Ropinirole hcl 2 mg tablet2.55USD tablet
Co Ropinirole 5 mg Tablet1.8USD tablet
Pms-Ropinirole 5 mg Tablet1.8USD tablet
Ran-Ropinirole 5 mg Tablet1.8USD tablet
Ropinirole 5 mg Tablet1.8USD tablet
Requip 2 mg Tablet1.41USD tablet
Requip 1 mg Tablet1.28USD tablet
Co Ropinirole 2 mg Tablet0.65USD tablet
Pms-Ropinirole 2 mg Tablet0.65USD tablet
Ran-Ropinirole 2 mg Tablet0.65USD tablet
Ropinirole 2 mg Tablet0.65USD tablet
Co Ropinirole 1 mg Tablet0.59USD tablet
Pms-Ropinirole 1 mg Tablet0.59USD tablet
Ran-Ropinirole 1 mg Tablet0.59USD tablet
Ropinirole 1 mg Tablet0.59USD tablet
Requip 0.25 mg Tablet0.32USD tablet
Co Ropinirole 0.25 mg Tablet0.15USD tablet
Pms-Ropinirole 0.25 mg Tablet0.15USD tablet
Ran-Ropinirole 0.25 mg Tablet0.15USD tablet
Ropinirole 0.25 mg Tablet0.15USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
CountryPatent NumberApprovedExpires (estimated)
United States54221231995-06-062012-06-06
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point243-250 °CNot Available
water solubility133 mg/mLNot Available
logP2.70ADLARD,M ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility0.353 mg/mLALOGPS
logP3.16ALOGPS
logP3.06ChemAxon
logS-2.9ALOGPS
pKa (Strongest Acidic)13.24ChemAxon
pKa (Strongest Basic)10.17ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area32.34 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity81.43 m3·mol-1ChemAxon
Polarizability31.19 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

DrugSyn.org

US4452808
General ReferenceNot Available
External Links
ATC CodesN04BC04
AHFS Codes
  • 28:36.20.08
PDB EntriesNot Available
FDA labelDownload (267 KB)
MSDSDownload (29.6 KB)
Interactions
Drug Interactions
Drug
CiprofloxacinCiprofloxacin may increase the effect and toxicity of ropinirole.
DihydrocodeineDihydrocodeine may enhance the sedative effect of ropinirole. It is recommended to monitor therapy
FluvoxamineIncreases the effect and toxicity of ropinirole
PaliperidoneThe atypical antipsychotic agent, paliperidone, may decrease the therapeutic effect of the anti-Parkinson's agent, ropinirole. This interaction may be due to the dopamine antagonist properties of paliperidone. Consider an alternate antipsychotic in those with Parkinson's disease or consider using clozapine or quetiapine if an atypical antipsychotic is necessary.
ThiothixeneThiothixene may antaonize the effects of the anti-Parkinsonian agent, Ropinirole. Consider alternate therapy or monitor for decreased effects of both agents.
ZiprasidoneThe atypical antipsychotic, ziprasidone, may antagonize the effect of the dopamine agonist, ropinirole. Consider alternate therapy or monitor for worsening of movement disorder.
ZuclopenthixolAntagonism may occur between zuclopenthixol, a dopamine D2 receptor antagonist, and ropinirole, a dopamine agonist. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of both agents if concurrent therapy is initiated, discontinued or dose(s) changed.
Food InteractionsNot Available

Targets

1. D(3) dopamine receptor

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: agonist

Components

Name UniProt ID Details
D(3) dopamine receptor P35462 Details

References:

  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed
  2. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. Pubmed
  3. Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. Pubmed

2. D(2) dopamine receptor

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: agonist

Components

Name UniProt ID Details
D(2) dopamine receptor P14416 Details

References:

  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed
  2. de Mey C, Enterling D, Meineke I, Yeulet S: Interactions between domperidone and ropinirole, a novel dopamine D2-receptor agonist. Br J Clin Pharmacol. 1991 Oct;32(4):483-8. Pubmed
  3. Iida M, Miyazaki I, Tanaka K, Kabuto H, Iwata-Ichikawa E, Ogawa N: Dopamine D2 receptor-mediated antioxidant and neuroprotective effects of ropinirole, a dopamine agonist. Brain Res. 1999 Aug 14;838(1-2):51-9. Pubmed
  4. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. Pubmed
  5. Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. Pubmed
  6. Matsukawa N, Maki M, Yasuhara T, Hara K, Yu G, Xu L, Kim KM, Morgan JC, Sethi KD, Borlongan CV: Overexpression of D2/D3 receptors increases efficacy of ropinirole in chronically 6-OHDA-lesioned Parkinsonian rats. Brain Res. 2007 Jul 30;1160:113-23. Epub 2007 May 26. Pubmed

3. D(4) dopamine receptor

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: agonist

Components

Name UniProt ID Details
D(4) dopamine receptor P21917 Details

References:

  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed
  2. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. Pubmed

4. 5-hydroxytryptamine receptor 1A

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: agonist

Components

Name UniProt ID Details
5-hydroxytryptamine receptor 1A P08908 Details

References:

  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. Pubmed

5. 5-hydroxytryptamine receptor 1D

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: agonist

Components

Name UniProt ID Details
5-hydroxytryptamine receptor 1D P28221 Details

References:

  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. Pubmed

6. 5-hydroxytryptamine receptor 2B

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: agonist

Components

Name UniProt ID Details
5-hydroxytryptamine receptor 2B P41595 Details

References:

  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. Pubmed

7. D(1A) dopamine receptor

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: agonist

Components

Name UniProt ID Details
D(1A) dopamine receptor P21728 Details

References:

  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. Pubmed

8. D(1B) dopamine receptor

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: agonist

Components

Name UniProt ID Details
D(1B) dopamine receptor P21918 Details

References:

  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. Pubmed

9. 5-hydroxytryptamine receptor 1B

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: agonist

Components

Name UniProt ID Details
5-hydroxytryptamine receptor 1B P28222 Details

References:

  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. Pubmed

10. 5-hydroxytryptamine receptor 2A

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: agonist

Components

Name UniProt ID Details
5-hydroxytryptamine receptor 2A P28223 Details

References:

  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. Pubmed

11. 5-hydroxytryptamine receptor 2C

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: agonist

Components

Name UniProt ID Details
5-hydroxytryptamine receptor 2C P28335 Details

References:

  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. Pubmed

12. Alpha-2A adrenergic receptor

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: agonist

Components

Name UniProt ID Details
Alpha-2A adrenergic receptor P08913 Details

References:

  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. Pubmed

13. Alpha-2B adrenergic receptor

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: agonist

Components

Name UniProt ID Details
Alpha-2B adrenergic receptor P18089 Details

References:

  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. Pubmed

14. Alpha-2C adrenergic receptor

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: agonist

Components

Name UniProt ID Details
Alpha-2C adrenergic receptor P18825 Details

References:

  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. Pubmed

Enzymes

1. Cytochrome P450 1A2

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 1A2 P05177 Details

References:

  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. Pubmed
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed
  3. Lexicomp

2. Cytochrome P450 3A4

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 3A4 P08684 Details

References:

  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. Pubmed
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

3. Cytochrome P450 2D6

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2D6 P10635 Details

References:

  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. Pubmed
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed
  3. Lexicomp

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Drug created on June 13, 2005 07:24 / Updated on October 08, 2013 14:25