You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.
Identification
NameVenlafaxine
Accession NumberDB00285  (APRD00125)
TypeSmall Molecule
GroupsApproved
Description

Venlafaxine (Effexor) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class first introduced by Wyeth in 1993. It is prescribed for the treatment of clinical depression and anxiety disorders. Due to the pronounced side effects and suspicions that venlafaxine may significantly increase the risk of suicide it is not recommended as a first line treatment of depression. However, it is often effective for depression not responding to SSRIs. Venlafaxine was the sixth most widely-used antidepressant based on the amount of retail prescriptions in the US (17.1 million) in 2006. [Wikipedia]

Structure
Thumb
Synonyms
Elafax
Venlafaxina
Venlafaxine
Venlafaxinum
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Act Venlafaxine XRcapsule (extended release)37.5 mgoralActavis Pharma Company2008-02-13Not applicableCanada
Act Venlafaxine XRcapsule (extended release)150.0 mgoralActavis Pharma Company2008-02-13Not applicableCanada
Act Venlafaxine XRcapsule (extended release)75.0 mgoralActavis Pharma Company2008-02-13Not applicableCanada
Auro-venlafaxine XRcapsule (extended release)150 mgoralAuro Pharma Inc2016-03-14Not applicableCanada
Auro-venlafaxine XRcapsule (extended release)75 mgoralAuro Pharma Inc2016-03-14Not applicableCanada
Auro-venlafaxine XRcapsule (extended release)37.5 mgoralAuro Pharma Inc2016-03-14Not applicableCanada
Dom-venlafaxine XRcapsule (extended release)150 mgoralDominion Pharmacal2013-05-30Not applicableCanada
Dom-venlafaxine XRcapsule (extended release)75 mgoralDominion Pharmacal2013-05-23Not applicableCanada
Dom-venlafaxine XRcapsule (extended release)37.5 mgoralDominion Pharmacal2013-05-23Not applicableCanada
Effexor Tablets, 37.5mgtablet37.5 mgoralWyeth Canada1994-12-312004-08-19Canada
Effexor Tablets, 50mgtablet50 mgoralWyeth Canada1995-12-312004-08-19Canada
Effexor Tablets, 75mgtablet75 mgoralWyeth Canada1994-12-312004-08-19Canada
Effexor XRcapsule, extended release150 mg/1oralbryant ranch prepack1997-11-01Not applicableUs
Effexor XRcapsule, extended release75 mg/1oralWyeth Pharmaceuticals Inc., a subsidiary of Pfizer Inc.1997-11-01Not applicableUs
Effexor XRcapsule, extended release37.5 mg/1oralCardinal Health1997-11-01Not applicableUs
Effexor XRcapsule (extended release)37.5 mgoralPfizer Canada Inc1998-03-04Not applicableCanada
Effexor XRcapsule, extended release75 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-01-31Not applicableUs
Effexor XRcapsule, extended release37.5 mg/1oralPhysicians Total Care, Inc.2004-04-07Not applicableUs
Effexor XRcapsule, extended release75 mg/1oralPhysicians Total Care, Inc.2003-04-25Not applicableUs
Effexor XRcapsule, extended release150 mg/1oralPhysicians Total Care, Inc.2001-08-28Not applicableUs
Effexor XRcapsule, extended release150 mg/1oralStat Rx USA1997-11-01Not applicableUs
Effexor XRcapsule, extended release37.5 mg/1oralWyeth Pharmaceuticals Inc., a subsidiary of Pfizer Inc.1997-11-01Not applicableUs
Effexor XRcapsule, extended release75 mg/1oralPd Rx Pharmaceuticals, Inc.1997-11-01Not applicableUs
Effexor XRcapsule, extended release75 mg/1oralStat Rx USA1997-11-01Not applicableUs
Effexor XRcapsule (extended release)150 mgoralPfizer Canada Inc1998-03-04Not applicableCanada
Effexor XRcapsule, extended release75 mg/1oralCardinal Health1997-11-01Not applicableUs
Effexor XRcapsule, extended release150 mg/1oralWyeth Pharmaceuticals Inc., a subsidiary of Pfizer Inc.1997-11-01Not applicableUs
Effexor XRcapsule, extended release150 mg/1oralCardinal Health1997-11-01Not applicableUs
Effexor XRcapsule, extended release150 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-05-25Not applicableUs
Effexor XRcapsule (extended release)75 mgoralPfizer Canada Inc1998-03-04Not applicableCanada
Effexor XRcapsule, extended release37.5 mg/1oralStat Rx USA1997-11-01Not applicableUs
Effexor XR Extended-releasecapsule, extended release150 mg/1oralRebel Distributors Corp1997-11-01Not applicableUs
Effexor XR Extended-releasecapsule, extended release75 mg/1oralRebel Distributors Corp1997-11-01Not applicableUs
Effexor XR Extended-releasecapsule, extended release37.5 mg/1oralRebel Distributors Corp1997-11-01Not applicableUs
Effexor XR Extended-releasecapsule, extended release150 mg/1oralAphena Pharma Solutions Tennessee, Inc.1997-11-01Not applicableUs
Gd-venlafaxine XRcapsule (extended release)150 mgoralGenmed A Division Of Pfizer Canada Inc2011-10-28Not applicableCanada
Gd-venlafaxine XRcapsule (extended release)75 mgoralGenmed A Division Of Pfizer Canada Inc2011-10-28Not applicableCanada
Gd-venlafaxine XRcapsule (extended release)37.5 mgoralGenmed A Division Of Pfizer Canada Inc2011-10-28Not applicableCanada
Mylan-venlafaxine XRcapsule (extended release)75 mgoralMylan Pharmaceuticals Ulc2008-05-07Not applicableCanada
Mylan-venlafaxine XRcapsule (extended release)37.5 mgoralMylan Pharmaceuticals Ulc2008-05-07Not applicableCanada
Mylan-venlafaxine XRcapsule (extended release)150 mgoralMylan Pharmaceuticals Ulc2008-05-07Not applicableCanada
Ntp-venlafaxine XRcapsule (extended release)75 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-venlafaxine XRcapsule (extended release)37.5 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-venlafaxine XRcapsule (extended release)150 mgoralTeva Canada LimitedNot applicableNot applicableCanada
PHL-venlafaxine XRcapsule (extended release)37.5 mgoralPharmel IncNot applicableNot applicableCanada
PHL-venlafaxine XRcapsule (extended release)150 mgoralPharmel IncNot applicableNot applicableCanada
PHL-venlafaxine XRcapsule (extended release)75 mgoralPharmel IncNot applicableNot applicableCanada
PMS-venlafaxine XRcapsule (extended release)37.5 mgoralPharmascience Inc2007-08-17Not applicableCanada
PMS-venlafaxine XRcapsule (extended release)150 mgoralPharmascience Inc2007-08-17Not applicableCanada
PMS-venlafaxine XRcapsule (extended release)75 mgoralPharmascience Inc2007-08-17Not applicableCanada
Ran-venlafaxine XRcapsule (extended release)75 mgoralRanbaxy Pharmaceuticals Canada Inc.2012-02-17Not applicableCanada
Ran-venlafaxine XRcapsule (extended release)37.5 mgoralRanbaxy Pharmaceuticals Canada Inc.2012-02-17Not applicableCanada
Ran-venlafaxine XRcapsule (extended release)150 mgoralRanbaxy Pharmaceuticals Canada Inc.2012-02-16Not applicableCanada
Riva-venlafaxine XRcapsule (extended release)150 mgoralLaboratoire Riva Inc2008-05-22Not applicableCanada
Riva-venlafaxine XRcapsule (extended release)75 mgoralLaboratoire Riva Inc2008-05-22Not applicableCanada
Riva-venlafaxine XRcapsule (extended release)37.5 mgoralLaboratoire Riva Inc2008-05-22Not applicableCanada
Sandoz Venlafaxine XRcapsule (extended release)37.5 mgoralSandoz Canada Incorporated2008-05-09Not applicableCanada
Sandoz Venlafaxine XRcapsule (extended release)150.0 mgoralSandoz Canada Incorporated2008-05-09Not applicableCanada
Sandoz Venlafaxine XRcapsule (extended release)75.0 mgoralSandoz Canada Incorporated2008-05-09Not applicableCanada
Teva-venlafaxine XRcapsule (extended release)75 mgoralTeva Canada Limited2006-12-01Not applicableCanada
Teva-venlafaxine XRcapsule (extended release)37.5 mgoralTeva Canada Limited2006-12-01Not applicableCanada
Teva-venlafaxine XRcapsule (extended release)150 mgoralTeva Canada Limited2006-12-01Not applicableCanada
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralRebel Distributors Corp2011-06-10Not applicableUs
Venlafaxine Hydrochloridetablet, extended release37.5 mg/1oralPhysicians Total Care, Inc.2010-06-11Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralRebel Distributors Corp2011-06-10Not applicableUs
Venlafaxine Hydrochloridetablet, film coated, extended release75 mg/1oralUpstate Pharma, LLC2008-10-10Not applicableUs
Venlafaxine Hydrochloridetablet, extended release225 mg/1oralKremers Urban Pharmaceuticals Inc.2010-04-29Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralGreenstone LLC2011-06-02Not applicableUs
Venlafaxine Hydrochloridecapsule, delayed release75 mg/1oralDIRECT RX2015-01-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralPreferred Pharmaceuticals, Inc.2014-04-18Not applicableUs
Venlafaxine Hydrochloridetablet, extended release150 mg/1oralKremers Urban Pharmaceuticals Inc.2010-04-29Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralGreenstone LLC2011-06-02Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralREMEDYREPACK INC.2012-03-14Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralDIRECT RX2014-01-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralCarilion Materials Management2011-06-02Not applicableUs
Venlafaxine Hydrochloridetablet, extended release75 mg/1oralKremers Urban Pharmaceuticals Inc.2010-04-29Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralClinical Solutions Wholesale2011-06-10Not applicableUs
Venlafaxine Hydrochloridetablet, extended release75 mg/1oralREMEDYREPACK INC.2011-11-17Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralApotex Corp.2011-06-10Not applicableUs
Venlafaxine Hydrochloridetablet, extended release37.5 mg/1oralKremers Urban Pharmaceuticals Inc.2010-04-29Not applicableUs
Venlafaxine Hydrochloridetablet, extended release225 mg/1oralClinical Solutions Wholesale2010-04-29Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralMedsource Pharmaceuticals2011-06-10Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralApotex Corp.2011-06-10Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralREMEDYREPACK INC.2013-05-08Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralCarilion Materials Management2011-06-02Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralMedsource Pharmaceuticals2011-06-10Not applicableUs
Venlafaxine Hydrochloridetablet, film coated, extended release225 mg/1oralUpstate Pharma, LLC2008-10-17Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralApotex Corp.2011-06-10Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralUnit Dose Services2011-06-10Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralRebel Distributors Corp2011-06-10Not applicableUs
Venlafaxine Hydrochloridetablet, film coated, extended release37.5 mg/1oralUpstate Pharma, LLC2008-09-30Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-06-10Not applicableUs
Venlafaxine Hydrochloridetablet, film coated, extended release150 mg/1oralUpstate Pharma, LLC2008-10-10Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralGreenstone LLC2011-06-02Not applicableUs
Venlafaxine Hydrochloride Extended-release Capsulescapsule (extended release)37.5 mgoralDr Reddys Laboratories IncNot applicableNot applicableCanada
Venlafaxine Hydrochloride Extended-release Capsulescapsule (extended release)150 mgoralDr Reddys Laboratories IncNot applicableNot applicableCanada
Venlafaxine Hydrochloride Extended-release Capsulescapsule (extended release)75 mgoralDr Reddys Laboratories IncNot applicableNot applicableCanada
Venlafaxine XRcapsule (extended release)37.5 mgoralSivem Pharmaceuticals Ulc2012-06-10Not applicableCanada
Venlafaxine XRcapsule (extended release)37.5 mgoralSanis Health Inc2010-07-27Not applicableCanada
Venlafaxine XRcapsule (extended release)37.5 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Venlafaxine XRcapsule (extended release)150 mgoralPro Doc Limitee2010-02-03Not applicableCanada
Venlafaxine XRcapsule (extended release)150 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Venlafaxine XRcapsule (extended release)150 mgoralPharmascience Inc2007-08-02Not applicableCanada
Venlafaxine XRcapsule (extended release)150.0 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Venlafaxine XRcapsule (extended release)75 mgoralPro Doc Limitee2010-02-03Not applicableCanada
Venlafaxine XRcapsule (extended release)75 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Venlafaxine XRcapsule (extended release)75 mgoralPharmascience Inc2007-08-02Not applicableCanada
Venlafaxine XRcapsule (extended release)75.0 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Venlafaxine XRcapsule (extended release)37.5 mgoralPro Doc Limitee2010-02-03Not applicableCanada
Venlafaxine XRcapsule (extended release)37.5 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Venlafaxine XRcapsule (extended release)37.5 mgoralPharmascience Inc2007-08-02Not applicableCanada
Venlafaxine XRcapsule (extended release)37.5 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Venlafaxine XRcapsule (extended release)150 mgoralSivem Pharmaceuticals Ulc2012-06-10Not applicableCanada
Venlafaxine XRcapsule (extended release)150 mgoralSanis Health Inc2010-07-27Not applicableCanada
Venlafaxine XRcapsule (extended release)150 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Venlafaxine XRcapsule (extended release)75 mgoralSivem Pharmaceuticals Ulc2012-06-10Not applicableCanada
Venlafaxine XRcapsule (extended release)75 mgoralSanis Health Inc2010-07-27Not applicableCanada
Venlafaxine XRcapsule (extended release)75 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-venlafaxine XRcapsule (extended release)150.0 mgoralApotex Inc2013-04-16Not applicableCanada
Apo-venlafaxine XRcapsule (extended release)75.0 mgoralApotex Inc2013-04-16Not applicableCanada
Apo-venlafaxine XRcapsule (extended release)37.5 mgoralApotex Inc2013-04-16Not applicableCanada
Venlafaxinetablet100 mg/1oralKAISER FOUNDATION HOSPITALS2014-09-03Not applicableUs
Venlafaxinetablet37.5 mg/1oralTrigen Laboratories, LLC2010-12-21Not applicableUs
Venlafaxinetablet37.5 mg/1oralHeritage Pharmaceuticals Inc.2012-11-30Not applicableUs
Venlafaxinetablet50 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2008-06-13Not applicableUs
Venlafaxinetablet100 mg/1oralClinical Solutions Wholesale2010-08-04Not applicableUs
Venlafaxinetablet75 mg/1oralDIRECT RX2015-01-01Not applicableUs
Venlafaxinetablet50 mg/1oralAurobindo Pharma Limited2010-04-07Not applicableUs
Venlafaxinetablet75 mg/1oralAmerican Health Packaging2015-02-15Not applicableUs
Venlafaxinetablet25 mg/1oralTrupharma, Llc2016-04-19Not applicableUs
Venlafaxinetablet75 mg/1oralTrigen Laboratories, LLC2010-12-21Not applicableUs
Venlafaxinetablet75 mg/1oralHeritage Pharmaceuticals Inc.2012-11-30Not applicableUs
Venlafaxinetablet37.5 mg/1oralClinical Solutions Wholesale2010-08-04Not applicableUs
Venlafaxinetablet100 mg/1oralAurobindo Pharma Limited2010-04-07Not applicableUs
Venlafaxinetablet50 mg/1oralAmerican Health Packaging2015-02-15Not applicableUs
Venlafaxinetablet50 mg/1oralTrupharma, Llc2016-04-19Not applicableUs
Venlafaxinetablet75 mg/1oralMylan Institutional Inc.2008-07-15Not applicableUs
Venlafaxinetablet75 mg/1oralNorth Star Rx Llc2010-12-21Not applicableUs
Venlafaxinetablet50 mg/1oralQualitest Pharmaceuticals2010-08-04Not applicableUs
Venlafaxinetablet50 mg/1oralSun Pharmaceutical Industries, Inc.2008-06-13Not applicableUs
Venlafaxinetablet75 mg/1oralAlembic Pharmaceuticals Inc.2015-10-01Not applicableUs
Venlafaxinetablet75 mg/1oralBlue Point Laboratories2013-11-25Not applicableUs
Venlafaxinetablet75 mg/1oralZydus Pharmaceuticals (USA) Inc.2008-06-13Not applicableUs
Venlafaxinetablet50 mg/1oralCitron Pharma LLC2010-04-07Not applicableUs
Venlafaxinetablet50 mg/1oralREMEDYREPACK INC.2013-05-29Not applicableUs
Venlafaxinetablet75 mg/1oralPd Rx Pharmaceuticals, Inc.2008-06-13Not applicableUs
Venlafaxinetablet50 mg/1oralKAISER FOUNDATION HOSPITALS2014-09-03Not applicableUs
Venlafaxinetablet25 mg/1oralTrigen Laboratories, LLC2010-12-21Not applicableUs
Venlafaxinetablet25 mg/1oralHeritage Pharmaceuticals Inc.2012-11-30Not applicableUs
Venlafaxinetablet75 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2008-06-13Not applicableUs
Venlafaxinetablet75 mg/1oralClinical Solutions Wholesale2010-08-04Not applicableUs
Venlafaxinetablet37.5 mg/1oralAurobindo Pharma Limited2010-04-07Not applicableUs
Venlafaxinetablet37.5 mg/1oralAmerican Health Packaging2015-02-15Not applicableUs
Venlafaxinetablet75 mg/1oralREMEDYREPACK INC.2016-01-25Not applicableUs
Venlafaxinetablet50 mg/1oralNorth Star Rx Llc2010-12-21Not applicableUs
Venlafaxinetablet37.5 mg/1oralSun Pharmaceutical Industries, Inc.2008-06-13Not applicableUs
Venlafaxinetablet50 mg/1oralAlembic Pharmaceuticals Inc.2015-10-01Not applicableUs
Venlafaxinetablet50 mg/1oralbryant ranch prepack2012-11-30Not applicableUs
Venlafaxinetablet50 mg/1oralBlue Point Laboratories2013-11-25Not applicableUs
Venlafaxinetablet50 mg/1oralZydus Pharmaceuticals (USA) Inc.2008-06-13Not applicableUs
Venlafaxinetablet37.5 mg/1oralCitron Pharma LLC2010-04-07Not applicableUs
Venlafaxinetablet25 mg/1oralREMEDYREPACK INC.2013-05-28Not applicableUs
Venlafaxinetablet25 mg/1oralKAISER FOUNDATION HOSPITALS2014-09-03Not applicableUs
Venlafaxinetablet37.5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2008-06-13Not applicableUs
Venlafaxinetablet50 mg/1oralClinical Solutions Wholesale2010-08-04Not applicableUs
Venlafaxinetablet50 mg/1oralREMEDYREPACK INC.2015-10-27Not applicableUs
Venlafaxinetablet75 mg/1oralProficient Rx LP2008-06-13Not applicableUs
Venlafaxinetablet25 mg/1oralAurobindo Pharma Limited2010-04-07Not applicableUs
Venlafaxinetablet37.5 mg/1oralNorth Star Rx Llc2010-12-21Not applicableUs
Venlafaxinetablet25 mg/1oralSun Pharmaceutical Industries, Inc.2008-06-13Not applicableUs
Venlafaxinetablet37.5 mg/1oralAlembic Pharmaceuticals Inc.2015-10-01Not applicableUs
Venlafaxinetablet37.5 mg/1oralBlue Point Laboratories2013-11-25Not applicableUs
Venlafaxinetablet37.5 mg/1oralZydus Pharmaceuticals (USA) Inc.2008-06-13Not applicableUs
Venlafaxinetablet25 mg/1oralCitron Pharma LLC2010-04-07Not applicableUs
Venlafaxinetablet37.5 mg/1oralQualitest Pharmaceuticals2010-08-04Not applicableUs
Venlafaxinetablet37.5 mg/1oralREMEDYREPACK INC.2015-10-19Not applicableUs
Venlafaxinetablet100 mg/1oralZydus Pharmaceuticals (USA) Inc.2008-06-13Not applicableUs
Venlafaxinetablet75 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Venlafaxinetablet25 mg/1oralNorth Star Rx Llc2010-12-21Not applicableUs
Venlafaxinetablet75 mg/1oralAidarex Pharmaceuticals LLC2012-11-30Not applicableUs
Venlafaxinetablet25 mg/1oralAlembic Pharmaceuticals Inc.2015-10-01Not applicableUs
Venlafaxinetablet25 mg/1oralBlue Point Laboratories2013-11-25Not applicableUs
Venlafaxinetablet25 mg/1oralZydus Pharmaceuticals (USA) Inc.2008-06-13Not applicableUs
Venlafaxinetablet100 mg/1oralREMEDYREPACK INC.2014-02-19Not applicableUs
Venlafaxinetablet25 mg/1oralQualitest Pharmaceuticals2010-08-04Not applicableUs
Venlafaxinetablet100 mg/1oralREMEDYREPACK INC.2015-10-09Not applicableUs
Venlafaxinetablet37.5 mg/1oralAidarex Pharmaceuticals LLC2012-11-30Not applicableUs
Venlafaxinetablet37.5 mg/1oralDIRECT RX2015-01-01Not applicableUs
Venlafaxinetablet100 mg/1oralBlue Point Laboratories2013-11-25Not applicableUs
Venlafaxinetablet100 mg/1oralTrupharma, Llc2016-04-19Not applicableUs
Venlafaxinetablet100 mg/1oralQualitest Pharmaceuticals2010-08-04Not applicableUs
Venlafaxinetablet100 mg/1oralSun Pharmaceutical Industries, Inc.2008-06-13Not applicableUs
Venlafaxinetablet25 mg/1oralREMEDYREPACK INC.2015-10-08Not applicableUs
Venlafaxinetablet100 mg/1oralCitron Pharma LLC2010-04-07Not applicableUs
Venlafaxinetablet37.5 mg/1oralREMEDYREPACK INC.2013-05-29Not applicableUs
Venlafaxinetablet25 mg/1oralClinical Solutions Wholesale2010-08-04Not applicableUs
Venlafaxinetablet75 mg/1oralDIRECT RX2014-01-01Not applicableUs
Venlafaxinetablet75 mg/1oralAurobindo Pharma Limited2010-04-07Not applicableUs
Venlafaxinetablet25 mg/1oralAmerican Health Packaging2015-02-15Not applicableUs
Venlafaxinetablet37.5 mg/1oralTrupharma, Llc2016-04-19Not applicableUs
Venlafaxinetablet37.5 mg/1oralMylan Institutional Inc.2008-07-15Not applicableUs
Venlafaxinetablet50 mg/1oralTrigen Laboratories, LLC2010-12-21Not applicableUs
Venlafaxinetablet50 mg/1oralHeritage Pharmaceuticals Inc.2012-11-30Not applicableUs
Venlafaxinetablet100 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2008-06-13Not applicableUs
Venlafaxinetablet100 mg/1oralTrigen Laboratories, LLC2010-12-21Not applicableUs
Venlafaxinetablet100 mg/1oralHeritage Pharmaceuticals Inc.2012-11-30Not applicableUs
Venlafaxinetablet50 mg/1oralDIRECT RX2014-01-01Not applicableUs
Venlafaxinetablet100 mg/1oralAmerican Health Packaging2015-02-15Not applicableUs
Venlafaxinetablet75 mg/1oralTrupharma, Llc2016-04-19Not applicableUs
Venlafaxinetablet75 mg/1oralQualitest Pharmaceuticals2010-08-04Not applicableUs
Venlafaxinetablet75 mg/1oralSun Pharmaceutical Industries, Inc.2008-06-13Not applicableUs
Venlafaxinetablet75 mg/1oralREMEDYREPACK INC.2015-10-08Not applicableUs
Venlafaxinetablet100 mg/1oralAlembic Pharmaceuticals Inc.2015-10-01Not applicableUs
Venlafaxinetablet75 mg/1oralCitron Pharma LLC2010-04-07Not applicableUs
Venlafaxinetablet75 mg/1oralREMEDYREPACK INC.2013-05-29Not applicableUs
Venlafaxinetablet100 mg/1oralNorth Star Rx Llc2010-12-21Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralAphena Pharma Solutions Tennessee, Llc2010-08-04Not applicableUs
Venlafaxine Hydrochloridetablet, extended release75 mg/1oralREMEDYREPACK INC.2013-04-11Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralPhysicians Total Care, Inc.2010-11-08Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralCardinal Health2011-06-01Not applicableUs
Venlafaxine Hydrochloridetablet, extended release37.5 mg/1oralSun Pharma Global Inc.2010-08-18Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralProficient Rx LP2010-07-01Not applicableUs
Venlafaxine Hydrochloridetablet25 mg/1oralAmneal Pharmaceuticals of New York, LLC2010-05-11Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralOrchid Healthcare (a division of Orchid Chemicals & Pharmaceuticals Ltd.)2012-07-07Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralAvera Mc Kennan Hospital2015-07-27Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralKAISER FOUNDATION HOSPITALS2014-10-27Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralWockhardt Limited2011-04-14Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralDIRECT RX2014-01-01Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralbryant ranch prepack2008-06-13Not applicableUs
Venlafaxine Hydrochloridetablet100 mg/1oralAmneal Pharmaceuticals of New York, LLC2010-05-11Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralAmerican Health Packaging2011-06-012015-12-31Us
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralClinical Solutions Wholesale, Llc2011-06-01Not applicableUs
Venlafaxine Hydrochloridetablet100 mg/1oralRebel Distributors Corp2008-06-13Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralAphena Pharma Solutions Tennessee, Llc2012-05-07Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralPhysicians Total Care, Inc.2010-11-08Not applicableUs
Venlafaxine Hydrochloridetablet25 mg/1oralTeva Pharmaceuticals USA Inc2006-08-04Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-06-28Not applicableUs
Venlafaxine Hydrochloridetablet100 mg/1oralAv Kare, Inc.2012-05-07Not applicableUs
Venlafaxine Hydrochloridetablet, extended release37.5 mg/1oralSun Pharma Global FZE2014-12-15Not applicableUs
Venlafaxine Hydrochloridetablet100 mg/1oralREMEDYREPACK INC.2014-03-24Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralDr. Reddy's Laboratories Limited2008-06-16Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralTeva Pharmaceuticals USA Inc2010-07-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralMajor Pharmaceuticals2015-04-06Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralRx Change Co.2014-11-27Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralREMEDYREPACK INC.2015-05-30Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2012-10-15Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralCadila Healthcare Limited2008-06-13Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralREMEDYREPACK INC.2011-08-05Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralPhysicians Total Care, Inc.2007-02-02Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralCardinal Health2011-06-01Not applicableUs
Venlafaxine Hydrochloridetablet, extended release75 mg/1oralSun Pharma Global Inc.2010-08-18Not applicableUs
Venlafaxine Hydrochloridecapsule, coated, extended release75 mg/1oralDIRECT RX2014-01-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralProficient Rx LP2010-07-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralTYA Pharmaceuticals2011-06-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralOrchid Healthcare (a division of Orchid Chemicals & Pharmaceuticals Ltd.)2012-07-07Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralUnit Dose Services2010-07-01Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralAv Kare, Inc.2012-05-07Not applicableUs
Venlafaxine Hydrochloridetablet, extended release75 mg/1oralSun Pharma Global FZE2014-12-15Not applicableUs
Venlafaxine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2014-03-11Not applicableUs
Venlafaxine Hydrochloridetablet25 mg/1oralDr. Reddy's Laboratories Limited2008-06-16Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralTeva Pharmaceuticals USA Inc2010-07-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralMajor Pharmaceuticals2011-06-07Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralAidarex Pharmaceuticals LLC2010-07-01Not applicableUs
Venlafaxine Hydrochloridetablet100 mg/1oralMylan Pharmaceuticals Inc.2008-06-14Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralREMEDYREPACK INC.2015-03-27Not applicableUs
Venlafaxine Hydrochloridetablet50 mg/1oralCadila Healthcare Limited2008-06-13Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralPd Rx Pharmaceuticals, Inc.2011-06-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralREMEDYREPACK INC.2011-08-04Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralPhysicians Total Care, Inc.2007-07-19Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralCardinal Health2011-06-07Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralTorrent Pharmaceuticals Limited2011-01-06Not applicableUs
Venlafaxine Hydrochloridetablet100 mg/1oralRebel Distributors Corp.2009-09-03Not applicableUs
Venlafaxine Hydrochloridetablet, extended release150 mg/1oralSun Pharma Global Inc.2010-08-18Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralTYA Pharmaceuticals2011-06-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralAmerican Health Packaging2014-02-03Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralPreferred Pharmaceuticals Inc.2015-09-11Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralAurobindo Pharma Limited2011-11-23Not applicableUs
Venlafaxine Hydrochloridetablet50 mg/1oralAv Kare, Inc.2012-05-07Not applicableUs
Venlafaxine Hydrochloridetablet, extended release150 mg/1oralSun Pharma Global FZE2014-12-15Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralREMEDYREPACK INC.2014-03-11Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralDr.Reddy's laboratories Ltd.2011-06-01Not applicableUs
Venlafaxine Hydrochloridetablet100 mg/1oralTeva Pharmaceuticals USA Inc2006-08-04Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralMajor Pharmaceuticals2011-06-07Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralAidarex Pharmaceuticals LLC2010-07-01Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralMylan Pharmaceuticals Inc.2008-06-14Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralSt. Marys Medical Park Pharmacy2011-01-30Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralbryant ranch prepack2010-07-01Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralCadila Healthcare Limited2008-06-13Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralClinical Solutions Wholesale, Llc2010-07-01Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralRebel Distributors Corp.2009-09-03Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-06-01Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralClinical Solutions Wholesale, Llc2006-08-04Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralProficient Rx LP2011-06-10Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralWockhardt USA LLC.2011-04-14Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralCadila Healthcare Limited2011-06-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralAmerican Health Packaging2014-02-03Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralAurobindo Pharma Limited2011-06-01Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralPd Rx Pharmaceuticals, Inc.2009-11-27Not applicableUs
Venlafaxine Hydrochloridetablet50 mg/1oralREMEDYREPACK INC.2011-05-02Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralCardinal Health2011-06-07Not applicableUs
Venlafaxine Hydrochloridetablet100 mg/1oralKAISER FOUNDATION HOSPITALS2012-01-05Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralTorrent Pharmaceuticals Limited2011-01-06Not applicableUs
Venlafaxine Hydrochloridetablet50 mg/1oralMylan Pharmaceuticals Inc.2008-06-14Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-08-04Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralGolden State Medical Supply, Inc2013-06-12Not applicableUs
Venlafaxine Hydrochloridetablet100 mg/1oralbryant ranch prepack2010-05-11Not applicableUs
Venlafaxine Hydrochloridetablet25 mg/1oralCadila Healthcare Limited2008-06-13Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralREMEDYREPACK INC.2016-01-11Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralClinical Solutions Wholesale, Llc2010-07-01Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralAv Kare, Inc.2012-05-07Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralAphena Pharma Solutions Tennessee, Llc2013-06-12Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralDr.Reddy's laboratories Ltd.2011-06-01Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralTeva Pharmaceuticals USA Inc2006-08-04Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralMajor Pharmaceuticals2011-06-07Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralRebel Distributors Corp.2009-09-03Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-07-01Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralClinical Solutions Wholesale, Llc2006-08-04Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralProficient Rx LP2011-06-10Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralWockhardt USA LLC.2011-04-14Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralCadila Healthcare Limited2011-06-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralAmerican Health Packaging2014-02-03Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralZydus Pharmaceuticals (USA) Inc.2011-06-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralAurobindo Pharma Limited2011-06-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralAv Kare, Inc.2013-07-10Not applicableUs
Venlafaxine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2011-04-25Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralH.J. Harkins Company, Inc.2008-06-13Not applicableUs
Venlafaxine Hydrochloridetablet100 mg/1oralDr. Reddy's Laboratories Limited2008-06-16Not applicableUs
Venlafaxine Hydrochloridetablet50 mg/1oralKAISER FOUNDATION HOSPITALS2012-01-05Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralTorrent Pharmaceuticals Limited2011-01-06Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralSTAT Rx USA LLC2009-11-27Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralMylan Pharmaceuticals Inc.2008-06-14Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralWockhardt Limited2011-04-14Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralGolden State Medical Supply, Inc2013-06-12Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralbryant ranch prepack2010-07-01Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralAmneal Pharmaceuticals of New York, LLC2010-05-11Not applicableUs
Venlafaxine Hydrochloridetablet25 mg/1oralCarilion Materials Management2006-08-04Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralAmerican Health Packaging2011-06-012015-12-31Us
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralClinical Solutions Wholesale, Llc2010-07-01Not applicableUs
Venlafaxine Hydrochloridetablet25 mg/1oralAv Kare, Inc.2012-05-07Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralAphena Pharma Solutions Tennessee, Llc2013-06-12Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralREMEDYREPACK INC.2013-05-03Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralDr.Reddy's laboratories Ltd.2011-06-01Not applicableUs
Venlafaxine Hydrochloridetablet50 mg/1oralTeva Pharmaceuticals USA Inc2006-08-04Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-07-01Not applicableUs
Venlafaxine Hydrochloridetablet25 mg/1oralRebel Distributors Corp.2009-09-03Not applicableUs
Venlafaxine Hydrochloridetablet, extended release75 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-12-06Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralProficient Rx LP2010-07-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralWockhardt USA LLC.2011-04-14Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralCadila Healthcare Limited2011-06-01Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralAmerican Health Packaging2009-01-13Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralZydus Pharmaceuticals (USA) Inc.2011-06-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralAv Kare, Inc.2013-07-10Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralREMEDYREPACK INC.2010-11-23Not applicableUs
Venlafaxine Hydrochloridetablet100 mg/1oralREMEDYREPACK INC.2014-04-15Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralDr. Reddy's Laboratories Limited2008-06-16Not applicableUs
Venlafaxine Hydrochloridetablet25 mg/1oralKAISER FOUNDATION HOSPITALS2012-01-05Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralMajor Pharmaceuticals2015-04-06Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralbryant ranch prepack2010-05-11Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralAmneal Pharmaceuticals of New York, LLC2010-05-11Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralOrchid Healthcare (a division of Orchid Chemicals & Pharmaceuticals Ltd.)2012-07-07Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralClinical Solutions Wholesale, Llc2011-06-01Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralAphena Pharma Solutions Tennessee, Llc2010-08-04Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralPhysicians Total Care, Inc.2010-08-02Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralCardinal Health2011-06-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralKAISER FOUNDATION HOSPITALS2014-10-27Not applicableUs
Venlafaxine Hydrochloridetablet25 mg/1oralRebel Distributors Corp2008-06-13Not applicableUs
Venlafaxine Hydrochloridetablet25 mg/1oralMylan Pharmaceuticals Inc.2008-06-14Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralWockhardt Limited2011-04-14Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralGolden State Medical Supply, Inc2013-06-12Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralbryant ranch prepack2010-06-28Not applicableUs
Venlafaxine Hydrochloridetablet50 mg/1oralAmneal Pharmaceuticals of New York, LLC2010-05-11Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralMed Vantx, Inc.2010-07-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralAmerican Health Packaging2011-06-012015-12-31Us
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralClinical Solutions Wholesale, Llc2011-11-23Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralRebel Distributors Corp2008-06-13Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralAphena Pharma Solutions Tennessee, Llc2012-05-07Not applicableUs
Venlafaxine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2013-02-20Not applicableUs
Venlafaxine Hydrochloridetablet100 mg/1oralPhysicians Total Care, Inc.2011-04-22Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralTeva Pharmaceuticals USA Inc2006-08-04Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-07-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2014-05-27Not applicableUs
Venlafaxine Hydrochloridetablet100 mg/1oralCadila Healthcare Limited2008-06-13Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralAmerican Health Packaging2009-01-13Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralZydus Pharmaceuticals (USA) Inc.2011-06-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralAv Kare, Inc.2013-07-10Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralREMEDYREPACK INC.2013-05-14Not applicableUs
Venlafaxine Hydrochloridetablet50 mg/1oralREMEDYREPACK INC.2014-04-09Not applicableUs
Venlafaxine Hydrochloridetablet50 mg/1oralDr. Reddy's Laboratories Limited2008-06-16Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralTeva Pharmaceuticals USA Inc2010-07-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralMajor Pharmaceuticals2015-04-06Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralLake Erie Medical DBA Quality Care Products LLC2008-06-13Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
EffexorNot Available
ElafaxNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Venlafaxine Hydrochloride
Thumb
  • InChI Key: QYRYFNHXARDNFZ-UHFFFAOYNA-N
  • Monoisotopic Mass: 313.180856852
  • Average Mass: 313.863
DBSALT000186
Categories
UNIIGRZ5RCB1QG
CAS number93413-69-5
WeightAverage: 277.4018
Monoisotopic: 277.204179113
Chemical FormulaC17H27NO2
InChI KeyInChIKey=PNVNVHUZROJLTJ-UHFFFAOYSA-N
InChI
InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3
IUPAC Name
1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol
SMILES
COC1=CC=C(C=C1)C(CN(C)C)C1(O)CCCCC1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenylpropylamines. These are compounds containing a phenylpropylamine moiety, which consists of a phenyl group substituted at the third carbon by an propan-1-amine.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassPhenylpropylamines
Direct ParentPhenylpropylamines
Alternative Parents
Substituents
  • Phenylpropylamine
  • Methoxybenzene
  • Phenol ether
  • Anisole
  • Aralkylamine
  • Cyclohexanol
  • Alkyl aryl ether
  • Tertiary alcohol
  • Cyclic alcohol
  • 1,3-aminoalcohol
  • Tertiary aliphatic amine
  • Tertiary amine
  • Ether
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Alcohol
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor the management of major depressive disorder (MDD), generalized anxiety disorder (GAD), social anxiety disorder (social phobia), panic disorder with or without agoraphobia, vasomotor symptoms in women with breast cancer and in postmenopausal women, and neuropathic pain.
PharmacodynamicsVenlafaxine potentiates the neurotransmitter activity in the central nervous system. Furthermore, venlafaxine and its metabolite, O-desmethylvenlafaxine (ODV) potently inhibit the reuptake of serotonin and norepinephrine and weakly inhibit dopamine reuptake. Both molecules do not bind to muscarinic, histaminergic, or alpha-1 adrenergic receptors. Pharmacologic activity at these receptors is hypothesized to be associated with the various anticholinergic, sedative, and cardiovascular effects seen with other psychotropic drugs. Both also do not have any monoamine oxidase (MAO) inhibitory activity.
Mechanism of actionThe exact mechanism of action of venlafaxine is unknown, but appears to be associated with the its potentiation of neurotransmitter activity in the CNS. Venlafaxine and its active metabolite, O-desmethylvenlafaxine (ODV), inhibit the reuptake of both serotonin and norepinephrine with a potency greater for the 5-HT than for the NE reuptake process. Both venlafaxine and the ODV metabolite have weak inhibitory effects on the reuptake of dopamine but, unlike the tricyclics and similar to SSRIs, they are not active at histaminergic, muscarinic, or alpha(1)-adrenergic receptors.
Related Articles
AbsorptionVenlafaxine is well absorbed. Food does not effect the absorption of venlafaxine or its subsequent metabolism into ODV. Bioavailability is 45% following oral administration. Time to steady state = 3 days.
Volume of distribution
  • 7.5 ± 3.7 L/kg [venlafaxine]
  • 5.7 ± 1.8 L/kg [O-desmethylvenlafaxine(active metabolite)]
Protein bindingThe degree of binding of venlafaxine to human plasma is 27% ± 2% at concentrations ranging from 2.5 to 2215 ng/mL. The degree of ODV binding to human plasma is 30% ± 12% at concentrations ranging from 100 to 500 ng/mL. Protein-binding-induced drug interactions with venlafaxine are not expected.
Metabolism

Undergoes extensive first pass metabolism in the liver to its major, active metabolite, ODV, and two minor, less active metabolites, N-desmethylvenlafaxine and N,O-didesmethylvenlafaxine. Formation of ODV is catalyzed by cytochrome P450 (CYP) 2D6, whereas N-demethylation is catalyzed by CYP3A4, 2C19 and 2C9. ODV possesses antidepressant activity that is comparable to that of venlfaxine.

SubstrateEnzymesProduct
Venlafaxine
O-DesmethylvenlafaxineDetails
Venlafaxine
N-DesmethylvenlafaxineDetails
O-Desmethylvenlafaxine
N,O-DidesmethylvenlafaxineDetails
N,O-Didesmethylvenlafaxine
Not Available
N,O-didesmethylvenlafaxine glucuronideDetails
N,O-Didesmethylvenlafaxine
Not Available
N,N,O-TridesmethylvenlafaxineDetails
O-Desmethylvenlafaxine
Not Available
O-Desmethylvenlafaxine glucuronideDetails
N-Desmethylvenlafaxine
N,O-DidesmethylvenlafaxineDetails
Route of eliminationRenal elimination of venlafaxine and its metabolites is the primary route of excretion. Approximately 87% of a venlafaxine dose is recovered in the urine within 48 hours as either unchanged venlafaxine (5%), unconjugated ODV (29%), conjugated ODV (26%), or other minor inactive metabolites (27%).
Half life5 hours
Clearance

Steady state plasma clearance, venlafaxine = 1.3 ± 0.6 L/h/kg;
Steady state plasma clearance, ODV = 0.4 ± 0.2 L/h/kg.

ToxicityMost patients overdosing with venlafaxine develop only mild symptoms. However, severe toxicity is reported with the most common symptoms being CNS depression, serotonin toxicity, seizure, or cardiac conduction abnormalities. Venlafaxine's toxicity appears to be higher than other SSRIs, with a fatal toxic dose closer to that of the tricyclic antidepressants than the SSRIs. Doses of 900 mg or more are likely to cause moderate toxicity. Deaths have been reported following large doses.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Venlafaxine Metabolism PathwayDrug metabolismSMP00636
SNP Mediated Effects
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeEffectReference(s)
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
Not AvailableCYP2D6*4A AllelePoor drug metabolizer, lower dose requirements, nausea, vomiting and diarrhea16958828
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
rs5030655 CYP2D6*6T deletionPoor drug metabolizer, lower dose requirements, nausea, vomiting and diarrhea16958828
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
rs5030655 CYP2D6*6T deletion, homozygotePoor drug metabolizer, lower dose requirements, nausea, vomiting and diarrhea16958828
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
Not AvailableCYP2D6*5DeletionPoor drug metabolizer, lower dose requirements, nausea, vomiting and diarrhea16958828
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
rs3892097 CYP2D6*4A AllelePoor drug metabolizer, lower dose requirements, nausea, vomiting and diarrhea16958828
Multidrug resistance protein 1
Gene symbol: ABCB1
UniProt: P08183
rs2032583 Not AvailableC AlleleImproved response to antidepressant medication17913323
Multidrug resistance protein 1
Gene symbol: ABCB1
UniProt: P08183
rs2032583 Not AvailableA > GIncrease risk of adverse effects22641028
SNP Mediated Adverse Drug Reactions
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeAdverse ReactionReference(s)
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
rs5030655 CYP2D6*4del T alleleNausea, vomiting diarrhea16958828
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
rs3892097 CYP2D6*6A alleleNausea, vomiting diarrhea16958828
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9782
Blood Brain Barrier+0.9382
Caco-2 permeable+0.852
P-glycoprotein substrateSubstrate0.6534
P-glycoprotein inhibitor IInhibitor0.7031
P-glycoprotein inhibitor IIInhibitor0.8031
Renal organic cation transporterNon-inhibitor0.5792
CYP450 2C9 substrateNon-substrate0.7583
CYP450 2D6 substrateSubstrate0.8919
CYP450 3A4 substrateSubstrate0.7407
CYP450 1A2 substrateNon-inhibitor0.7664
CYP450 2C9 inhibitorNon-inhibitor0.6876
CYP450 2D6 inhibitorInhibitor0.7287
CYP450 2C19 inhibitorNon-inhibitor0.7199
CYP450 3A4 inhibitorNon-inhibitor0.8308
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8666
Ames testNon AMES toxic0.8
CarcinogenicityNon-carcinogens0.6762
BiodegradationNot ready biodegradable0.9941
Rat acute toxicity2.5404 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.5486
hERG inhibition (predictor II)Inhibitor0.6627
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Wyeth pharmaceuticals inc
  • Teva pharmaceuticals usa inc
  • Osmotica pharmaceutical corp
  • Actavis totowa llc
  • Amneal pharmaceuticals
  • Aurobindo pharma ltd
  • Caraco pharmaceutical laboratories ltd
  • Dr reddys laboratories ltd
  • Mylan pharmaceuticals inc
  • Pliva hrvatska doo
  • Sandoz inc
  • Vintage pharmaceuticals llc
  • Zydus pharmaceuticals usa inc
  • Wyeth
Packagers
Dosage forms
FormRouteStrength
Capsule (extended release)oral150.0 mg
Capsule (extended release)oral75.0 mg
Tabletoral37.5 mg
Tabletoral50 mg
Tabletoral75 mg
Capsule (extended release)oral150 mg
Capsule (extended release)oral37.5 mg
Capsule (extended release)oral75 mg
Capsule, extended releaseoral150 mg/1
Capsule, extended releaseoral37.5 mg/1
Capsule, extended releaseoral75 mg/1
Capsule, coated, extended releaseoral75 mg/1
Capsule, delayed releaseoral75 mg/1
Tabletoral100 mg/1
Tabletoral25 mg/1
Tabletoral37.5 mg/1
Tabletoral50 mg/1
Tabletoral75 mg/1
Tablet, extended releaseoral150 mg/1
Tablet, extended releaseoral225 mg/1
Tablet, extended releaseoral37.5 mg/1
Tablet, extended releaseoral75 mg/1
Tablet, film coated, extended releaseoral150 mg/1
Tablet, film coated, extended releaseoral225 mg/1
Tablet, film coated, extended releaseoral37.5 mg/1
Tablet, film coated, extended releaseoral75 mg/1
Prices
Unit descriptionCostUnit
Venlafaxine HCl 30 225 mg 24 Hour tablet Bottle276.98USD bottle
Effexor XR 30 37.5 mg 24 Hour Capsule Bottle144.33USD bottle
Venlafaxine HCl 30 37.5 mg 24 Hour tablet Bottle114.46USD bottle
Effexor 30 75 mg tablet Bottle87.83USD bottle
Effexor 30 25 mg tablet Bottle74.82USD bottle
Effexor XR 150 mg 24 Hour Capsule5.87USD capsule
Effexor xr 150 mg capsule5.65USD capsule
Effexor XR 75 mg 24 Hour Capsule5.39USD capsule
Effexor xr 75 mg capsule4.76USD capsule
Venlafaxine HCl 150 mg 24 Hour tablet4.72USD tablet
Effexor xr 37.5 mg capsule4.63USD capsule
Venlafaxine HCl 75 mg 24 Hour tablet4.42USD tablet
Effexor 100 mg tablet2.92USD tablet
Effexor 75 mg tablet2.7USD tablet
Effexor 50 mg tablet2.6USD tablet
Effexor 37.5 mg tablet2.5USD tablet
Effexor 25 mg tablet2.4USD tablet
Venlafaxine hcl 100 mg tablet2.36USD tablet
Venlafaxine hcl 75 mg tablet2.23USD tablet
Effexor Xr 150 mg Extended-Release Capsule2.16USD capsule
Venlafaxine hcl 50 mg tablet2.1USD tablet
Effexor Xr 75 mg Extended-Release Capsule2.05USD capsule
Venlafaxine hcl 37.5 mg tablet2.04USD tablet
Venlafaxine hcl 25 mg tablet1.98USD tablet
Apo-Venlafaxine Xr 150 mg Extended-Release Capsule1.2USD capsule
Co Venlafaxine Xr 150 mg Extended-Release Capsule1.2USD capsule
Mylan-Venlafaxine Xr 150 mg Extended-Release Capsule1.2USD capsule
Novo-Venlafaxine Xr 150 mg Extended-Release Capsule1.2USD capsule
Pms-Venlafaxine Xr 150 mg Extended-Release Capsule1.2USD capsule
Ratio-Venlafaxine Xr 150 mg Extended-Release Capsule1.2USD capsule
Sandoz Venlafaxine Xr 150 mg Extended-Release Capsule1.2USD capsule
Apo-Venlafaxine Xr 75 mg Extended-Release Capsule1.14USD capsule
Co Venlafaxine Xr 75 mg Extended-Release Capsule1.14USD capsule
Mylan-Venlafaxine Xr 75 mg Extended-Release Capsule1.14USD capsule
Novo-Venlafaxine Xr 75 mg Extended-Release Capsule1.14USD capsule
Pms-Venlafaxine Xr 75 mg Extended-Release Capsule1.14USD capsule
Ratio-Venlafaxine Xr 75 mg Extended-Release Capsule1.14USD capsule
Sandoz Venlafaxine Xr 75 mg Extended-Release Capsule1.14USD capsule
Effexor Xr 37.5 mg Extended-Release Capsule1.02USD capsule
Apo-Venlafaxine Xr 37.5 mg Extended-Release Capsule0.57USD capsule
Co Venlafaxine Xr 37.5 mg Extended-Release Capsule0.57USD capsule
Mylan-Venlafaxine Xr 37.5 mg Extended-Release Capsule0.57USD capsule
Novo-Venlafaxine Xr 37.5 mg Extended-Release Capsule0.57USD capsule
Pms-Venlafaxine Xr 37.5 mg Extended-Release Capsule0.57USD capsule
Ratio-Venlafaxine Xr 37.5 mg Extended-Release Capsule0.57USD capsule
Sandoz Venlafaxine Xr 37.5 mg Extended-Release Capsule0.57USD capsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2126305 No2006-10-172014-06-20Canada
CA2199778 No2005-12-202017-03-12Canada
US5916923 No1993-06-282013-06-28Us
US6274171 Yes1997-09-202017-09-20Us
US6403120 Yes1997-09-202017-09-20Us
US6419958 Yes1997-09-202017-09-20Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point215-217 °C (Hydrochloride salt)Not Available
water solubility572 mg/ml (Hydrochloride salt)Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.23 mg/mLALOGPS
logP2.69ALOGPS
logP2.74ChemAxon
logS-3.1ALOGPS
pKa (Strongest Acidic)14.42ChemAxon
pKa (Strongest Basic)8.91ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area32.7 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity83.02 m3·mol-1ChemAxon
Polarizability32.33 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
Synthesis Reference

Thomas P. Jerussi, Chrisantha H. Senanayake, “Derivatives of (+)-venlafaxine and methods of preparing and using the same.” U.S. Patent US6197828, issued June, 1994.

US6197828
General References
  1. Golden RN, Nicholas L: Antidepressant efficacy of venlafaxine. Depress Anxiety. 2000;12 Suppl 1:45-9. [PubMed:11098413 ]
  2. Thase ME, Clayton AH, Haight BR, Thompson AH, Modell JG, Johnston JA: A double-blind comparison between bupropion XL and venlafaxine XR: sexual functioning, antidepressant efficacy, and tolerability. J Clin Psychopharmacol. 2006 Oct;26(5):482-8. [PubMed:16974189 ]
  3. Bielski RJ, Ventura D, Chang CC: A double-blind comparison of escitalopram and venlafaxine extended release in the treatment of major depressive disorder. J Clin Psychiatry. 2004 Sep;65(9):1190-6. [PubMed:15367045 ]
  4. Rowbotham MC, Goli V, Kunz NR, Lei D: Venlafaxine extended release in the treatment of painful diabetic neuropathy: a double-blind, placebo-controlled study. Pain. 2004 Aug;110(3):697-706. [PubMed:15288411 ]
  5. Ozyalcin SN, Talu GK, Kiziltan E, Yucel B, Ertas M, Disci R: The efficacy and safety of venlafaxine in the prophylaxis of migraine. Headache. 2005 Feb;45(2):144-52. [PubMed:15705120 ]
  6. Whirl-Carrillo M, McDonagh EM, Hebert JM, Gong L, Sangkuhl K, Thorn CF, Altman RB, Klein TE: Pharmacogenomics knowledge for personalized medicine. Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96. [PubMed:22992668 ]
  7. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
External Links
ATC CodesN06AX16
AHFS Codes
  • 28:16.04.92
PDB EntriesNot Available
FDA labelDownload (3.38 MB)
MSDSDownload (36.5 KB)
Interactions
Drug Interactions
Drug
AbciximabVenlafaxine may increase the anticoagulant activities of Abciximab.
AbirateroneThe serum concentration of Venlafaxine can be increased when it is combined with Abiraterone.
AcenocoumarolThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Acenocoumarol.
AcepromazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Acepromazine.
AcetophenazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Acetophenazine.
Acetylsalicylic acidVenlafaxine may increase the antiplatelet activities of Acetylsalicylic acid.
AlteplaseVenlafaxine may increase the anticoagulant activities of Alteplase.
AmisulprideThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Amisulpride.
AnistreplaseVenlafaxine may increase the anticoagulant activities of Anistreplase.
ApixabanThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Apixaban.
AprepitantThe serum concentration of Venlafaxine can be increased when it is combined with Aprepitant.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Venlafaxine.
ArticaineVenlafaxine may increase the tachycardic activities of Articaine.
BenzquinamideThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Benzquinamide.
BexaroteneThe serum concentration of Venlafaxine can be decreased when it is combined with Bexarotene.
BosentanThe serum concentration of Venlafaxine can be decreased when it is combined with Bosentan.
BrimonidineVenlafaxine may decrease the antihypertensive activities of Brimonidine.
CaffeineVenlafaxine may increase the antiplatelet activities of Caffeine.
CarphenazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Carphenazine.
ChlormezanoneThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Chlormezanone.
ChlorpromazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Chlorpromazine.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Chlorprothixene.
CitalopramVenlafaxine may increase the QTc-prolonging activities of Citalopram.
Citric AcidVenlafaxine may increase the anticoagulant activities of Citric Acid.
ClonidineVenlafaxine may decrease the antihypertensive activities of Clonidine.
ClozapineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Clozapine.
CollagenaseThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Collagenase.
ConivaptanThe serum concentration of Venlafaxine can be increased when it is combined with Conivaptan.
Dabigatran etexilateVenlafaxine may increase the anticoagulant activities of Dabigatran etexilate.
DabrafenibThe serum concentration of Venlafaxine can be decreased when it is combined with Dabrafenib.
DalteparinVenlafaxine may increase the anticoagulant activities of Dalteparin.
DapoxetineThe risk or severity of adverse effects can be increased when Dapoxetine is combined with Venlafaxine.
DasatinibDasatinib may increase the anticoagulant activities of Venlafaxine.
DeferasiroxThe serum concentration of Venlafaxine can be decreased when it is combined with Deferasirox.
Deoxycholic AcidThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Deoxycholic Acid.
DesmopressinVenlafaxine may increase the antiplatelet activities of Desmopressin.
DexmedetomidineVenlafaxine may decrease the antihypertensive activities of Dexmedetomidine.
DiclofenacVenlafaxine may increase the antiplatelet activities of Diclofenac.
DicoumarolThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Dicoumarol.
DiflunisalVenlafaxine may increase the antiplatelet activities of Diflunisal.
DihydrocodeineVenlafaxine may increase the antiplatelet activities of Dihydrocodeine.
DipivefrinVenlafaxine may decrease the antihypertensive activities of Dipivefrin.
DofetilideVenlafaxine may increase the QTc-prolonging activities of Dofetilide.
DopamineVenlafaxine may increase the tachycardic activities of Dopamine.
DroperidolThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Droperidol.
Edetic AcidVenlafaxine may increase the anticoagulant activities of Edetic Acid.
EnoxaparinVenlafaxine may increase the anticoagulant activities of Enoxaparin.
EphedrineVenlafaxine may increase the tachycardic activities of Ephedrine.
EpinephrineVenlafaxine may increase the tachycardic activities of Epinephrine.
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Venlafaxine.
Ethyl biscoumacetateVenlafaxine may increase the anticoagulant activities of Ethyl biscoumacetate.
EtodolacVenlafaxine may increase the antiplatelet activities of Etodolac.
FencamfamineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Fencamfamine.
FenoprofenVenlafaxine may increase the antiplatelet activities of Fenoprofen.
FloctafenineVenlafaxine may increase the antiplatelet activities of Floctafenine.
FluconazoleThe metabolism of Venlafaxine can be decreased when combined with Fluconazole.
FluoxetineThe metabolism of Venlafaxine can be decreased when combined with Fluoxetine.
FlupentixolThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Flupentixol.
FluphenazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Fluphenazine.
FlurbiprofenVenlafaxine may increase the antiplatelet activities of Flurbiprofen.
FluspirileneThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Fluspirilene.
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Venlafaxine.
Fondaparinux sodiumVenlafaxine may increase the anticoagulant activities of Fondaparinux sodium.
FosaprepitantThe serum concentration of Venlafaxine can be increased when it is combined with Fosaprepitant.
Fusidic AcidThe serum concentration of Venlafaxine can be increased when it is combined with Fusidic Acid.
GlucosamineGlucosamine may increase the antiplatelet activities of Venlafaxine.
GoserelinVenlafaxine may increase the QTc-prolonging activities of Goserelin.
GranisetronGranisetron may increase the serotonergic activities of Venlafaxine.
GuanfacineVenlafaxine may decrease the antihypertensive activities of Guanfacine.
HaloperidolThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Haloperidol.
HeparinVenlafaxine may increase the anticoagulant activities of Heparin.
Ibritumomab tiuxetanThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Ibritumomab.
IbrutinibThe risk or severity of adverse effects can be increased when Ibrutinib is combined with Venlafaxine.
IbuprofenVenlafaxine may increase the antiplatelet activities of Ibuprofen.
IdelalisibThe serum concentration of Venlafaxine can be increased when it is combined with Idelalisib.
IndinavirThe serum concentration of Indinavir can be decreased when it is combined with Venlafaxine.
IndomethacinVenlafaxine may increase the antiplatelet activities of Indomethacin.
IobenguaneThe therapeutic efficacy of Iobenguane can be decreased when used in combination with Venlafaxine.
Ioflupane I 123Venlafaxine may decrease effectiveness of Ioflupane I 123 as a diagnostic agent.
IsocarboxazidIsocarboxazid may increase the serotonergic activities of Venlafaxine.
IvacaftorThe serum concentration of Venlafaxine can be increased when it is combined with Ivacaftor.
KetoprofenVenlafaxine may increase the antiplatelet activities of Ketoprofen.
KetorolacVenlafaxine may increase the antiplatelet activities of Ketorolac.
LeuprolideVenlafaxine may increase the QTc-prolonging activities of Leuprolide.
LevonordefrinVenlafaxine may increase the tachycardic activities of Levonordefrin.
LimaprostLimaprost may increase the antiplatelet activities of Venlafaxine.
LinezolidLinezolid may increase the serotonergic activities of Venlafaxine.
LoxapineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Loxapine.
LuliconazoleThe serum concentration of Venlafaxine can be increased when it is combined with Luliconazole.
Mefenamic acidVenlafaxine may increase the antiplatelet activities of Mefenamic acid.
MeloxicamVenlafaxine may increase the antiplatelet activities of Meloxicam.
MepivacaineVenlafaxine may increase the tachycardic activities of Mepivacaine.
MesoridazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Mesoridazine.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Methotrimeprazine.
MethyldopaVenlafaxine may decrease the antihypertensive activities of Methyldopa.
Methylene blueVenlafaxine may increase the serotonergic activities of Methylene blue.
MetoclopramideThe risk or severity of adverse effects can be increased when Metoclopramide is combined with Venlafaxine.
MifepristoneThe serum concentration of Venlafaxine can be increased when it is combined with Mifepristone.
MitotaneThe serum concentration of Venlafaxine can be decreased when it is combined with Mitotane.
MoclobemideMoclobemide may increase the serotonergic activities of Venlafaxine.
MolindoneThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Molindone.
NabumetoneVenlafaxine may increase the antiplatelet activities of Nabumetone.
NaproxenVenlafaxine may increase the antiplatelet activities of Naproxen.
NelfinavirThe metabolism of Venlafaxine can be decreased when combined with Nelfinavir.
NetupitantThe serum concentration of Venlafaxine can be increased when it is combined with Netupitant.
NorepinephrineVenlafaxine may increase the tachycardic activities of Norepinephrine.
ObinutuzumabThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Obinutuzumab.
OlanzapineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Olanzapine.
Omega-3 fatty acidsOmega-3 fatty acids may increase the antiplatelet activities of Venlafaxine.
OndansetronThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Ondansetron.
OxaprozinVenlafaxine may increase the antiplatelet activities of Oxaprozin.
PalbociclibThe serum concentration of Venlafaxine can be increased when it is combined with Palbociclib.
PaliperidoneThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Paliperidone.
PanobinostatThe serum concentration of Venlafaxine can be increased when it is combined with Panobinostat.
Peginterferon alfa-2bThe serum concentration of Venlafaxine can be decreased when it is combined with Peginterferon alfa-2b.
Pentosan PolysulfateThe risk or severity of adverse effects can be increased when Pentosan Polysulfate is combined with Venlafaxine.
PentoxifyllinePentoxifylline may increase the antiplatelet activities of Venlafaxine.
PerphenazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Perphenazine.
PhenelzinePhenelzine may increase the serotonergic activities of Venlafaxine.
PhenindioneVenlafaxine may increase the anticoagulant activities of Phenindione.
PhenprocoumonVenlafaxine may increase the anticoagulant activities of Phenprocoumon.
PhenytoinThe metabolism of Venlafaxine can be increased when combined with Phenytoin.
PimozideThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Pimozide.
PiperacetazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Piperacetazine.
PiroxicamVenlafaxine may increase the antiplatelet activities of Piroxicam.
ProcarbazineProcarbazine may increase the serotonergic activities of Venlafaxine.
ProchlorperazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Prochlorperazine.
PromazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Promazine.
PropafenoneThe serum concentration of Venlafaxine can be increased when it is combined with Propafenone.
PseudoephedrineVenlafaxine may increase the tachycardic activities of Pseudoephedrine.
QuetiapineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Quetiapine.
RacepinephrineVenlafaxine may increase the tachycardic activities of Racepinephrine.
RasagilineRasagiline may increase the serotonergic activities of Venlafaxine.
RemoxiprideThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Remoxipride.
ReserpineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Reserpine.
ReteplaseVenlafaxine may increase the anticoagulant activities of Reteplase.
RidogrelVenlafaxine may increase the anticoagulant activities of Ridogrel.
RisperidoneThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Risperidone.
RitonavirThe metabolism of Venlafaxine can be decreased when combined with Ritonavir.
RivaroxabanVenlafaxine may increase the anticoagulant activities of Rivaroxaban.
SelegilineSelegiline may increase the serotonergic activities of Venlafaxine.
SertindoleThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Sertindole.
SiltuximabThe serum concentration of Venlafaxine can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Venlafaxine can be increased when it is combined with Simeprevir.
St. John's WortThe serum concentration of Venlafaxine can be decreased when it is combined with St. John's Wort.
StiripentolThe serum concentration of Venlafaxine can be increased when it is combined with Stiripentol.
StreptokinaseVenlafaxine may increase the anticoagulant activities of Streptokinase.
SulindacVenlafaxine may increase the antiplatelet activities of Sulindac.
SulodexideVenlafaxine may increase the anticoagulant activities of Sulodexide.
SulpirideThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Sulpiride.
Tedizolid PhosphateTedizolid Phosphate may increase the serotonergic activities of Venlafaxine.
TenecteplaseVenlafaxine may increase the anticoagulant activities of Tenecteplase.
ThioridazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Thioridazine.
ThiothixeneThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Thiothixene.
Tiaprofenic acidVenlafaxine may increase the antiplatelet activities of Tiaprofenic acid.
TiclopidineThe metabolism of Venlafaxine can be decreased when combined with Ticlopidine.
TizanidineVenlafaxine may decrease the antihypertensive activities of Tizanidine.
TocilizumabThe serum concentration of Venlafaxine can be decreased when it is combined with Tocilizumab.
TolmetinVenlafaxine may increase the antiplatelet activities of Tolmetin.
TositumomabThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Tositumomab.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Venlafaxine.
TranylcypromineTranylcypromine may increase the serotonergic activities of Venlafaxine.
TrazodoneVenlafaxine may increase the serotonergic activities of Trazodone.
TreprostinilVenlafaxine may increase the anticoagulant activities of Treprostinil.
TrifluoperazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Trifluoperazine.
TriflupromazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Triflupromazine.
TriprolidineVenlafaxine may increase the tachycardic activities of Triprolidine.
UrokinaseVenlafaxine may increase the anticoagulant activities of Urokinase.
Vitamin EVitamin E may increase the antiplatelet activities of Venlafaxine.
VoriconazoleThe risk or severity of adverse effects can be increased when Voriconazole is combined with Venlafaxine.
WarfarinThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Warfarin.
ZiprasidoneThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Ziprasidone.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Zuclopenthixol.
Food Interactions
  • Avoid alcohol.
  • Avoid St.John's Wort.
  • Take with food.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Serotonin:sodium symporter activity
Specific Function:
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin an...
Gene Name:
SLC6A4
Uniprot ID:
P31645
Molecular Weight:
70324.165 Da
References
  1. Chen F, Larsen MB, Sanchez C, Wiborg O: The S-enantiomer of R,S-citalopram, increases inhibitor binding to the human serotonin transporter by an allosteric mechanism. Comparison with other serotonin transporter inhibitors. Eur Neuropsychopharmacol. 2005 Mar;15(2):193-8. [PubMed:15695064 ]
  2. Gould GG, Altamirano AV, Javors MA, Frazer A: A comparison of the chronic treatment effects of venlafaxine and other antidepressants on serotonin and norepinephrine transporters. Biol Psychiatry. 2006 Mar 1;59(5):408-14. Epub 2005 Sep 2. [PubMed:16140280 ]
  3. Shang Y, Gibbs MA, Marek GJ, Stiger T, Burstein AH, Marek K, Seibyl JP, Rogers JF: Displacement of serotonin and dopamine transporters by venlafaxine extended release capsule at steady state: a [123I]2beta-carbomethoxy-3beta-(4-iodophenyl)-tropane single photon emission computed tomography imaging study. J Clin Psychopharmacol. 2007 Feb;27(1):71-5. [PubMed:17224717 ]
  4. Malizia AL, Melichar JM, Brown DJ, Gunn RN, Reynolds A, Jones T, Nutt DJ: Demonstration of clomipramine and venlafaxine occupation at serotonin reuptake sites in man in vivo. J Psychopharmacol. 1997;11(3):279-81. [PubMed:9305421 ]
  5. Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. [PubMed:9537821 ]
  6. Van Ameringen M, Mancini C, Patterson B, Simpson W: Pharmacotherapy for social anxiety disorder: an update. Isr J Psychiatry Relat Sci. 2009;46(1):53-61. [PubMed:19728573 ]
  7. Beique J, de Montigny C, Blier P, Debonnel G: Effects of sustained administration of the serotonin and norepinephrine reuptake inhibitor venlafaxine: I. in vivo electrophysiological studies in the rat. Neuropharmacology. 2000 Jul 24;39(10):1800-12. [PubMed:10884561 ]
  8. Westenberg HG: Recent advances in understanding and treating social anxiety disorder. CNS Spectr. 2009 Feb;14(2 Suppl 3):24-33. [PubMed:19238127 ]
  9. Sindrup SH, Otto M, Finnerup NB, Jensen TS: Antidepressants in the treatment of neuropathic pain. Basic Clin Pharmacol Toxicol. 2005 Jun;96(6):399-409. [PubMed:15910402 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Norepinephrine:sodium symporter activity
Specific Function:
Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name:
SLC6A2
Uniprot ID:
P23975
Molecular Weight:
69331.42 Da
References
  1. Vaishnavi SN, Nemeroff CB, Plott SJ, Rao SG, Kranzler J, Owens MJ: Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity. Biol Psychiatry. 2004 Feb 1;55(3):320-2. [PubMed:14744476 ]
  2. Mitchell HA, Ahern TH, Liles LC, Javors MA, Weinshenker D: The effects of norepinephrine transporter inactivation on locomotor activity in mice. Biol Psychiatry. 2006 Nov 15;60(10):1046-52. Epub 2006 Aug 7. [PubMed:16893531 ]
  3. Beique JC, Lavoie N, de Montigny C, Debonnel G: Affinities of venlafaxine and various reuptake inhibitors for the serotonin and norepinephrine transporters. Eur J Pharmacol. 1998 May 15;349(1):129-32. [PubMed:9669506 ]
  4. Van Ameringen M, Mancini C, Patterson B, Simpson W: Pharmacotherapy for social anxiety disorder: an update. Isr J Psychiatry Relat Sci. 2009;46(1):53-61. [PubMed:19728573 ]
  5. Beique J, de Montigny C, Blier P, Debonnel G: Effects of sustained administration of the serotonin and norepinephrine reuptake inhibitor venlafaxine: I. in vivo electrophysiological studies in the rat. Neuropharmacology. 2000 Jul 24;39(10):1800-12. [PubMed:10884561 ]
  6. Westenberg HG: Recent advances in understanding and treating social anxiety disorder. CNS Spectr. 2009 Feb;14(2 Suppl 3):24-33. [PubMed:19238127 ]
  7. Sindrup SH, Otto M, Finnerup NB, Jensen TS: Antidepressants in the treatment of neuropathic pain. Basic Clin Pharmacol Toxicol. 2005 Jun;96(6):399-409. [PubMed:15910402 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Monoamine transmembrane transporter activity
Specific Function:
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name:
SLC6A3
Uniprot ID:
Q01959
Molecular Weight:
68494.255 Da
References
  1. Dawson LA, Nguyen HQ, Geiger A: Effects of venlafaxine on extracellular concentrations of 5-HT and noradrenaline in the rat frontal cortex: augmentation via 5-HT1A receptor antagonism. Neuropharmacology. 1999 Aug;38(8):1153-63. [PubMed:10462128 ]
  2. Bourin M: [Psychopharmacological profile of venlafaxine]. Encephale. 1999 Jun;25 Spec No 2:21-2; discussion 23-5. [PubMed:10434156 ]
  3. Barkin RL, Fawcett J: The management challenges of chronic pain: the role of antidepressants. Am J Ther. 2000 Jan;7(1):31-47. [PubMed:11319571 ]
  4. Lemke MR: [Antidepressant effects of dopamine agonists. Experimental and clinical findings]. Nervenarzt. 2007 Jan;78(1):31-8. [PubMed:17187269 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Fogelman SM, Schmider J, Venkatakrishnan K, von Moltke LL, Harmatz JS, Shader RI, Greenblatt DJ: O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: effect of metabolic inhibitors and SSRI antidepressants. Neuropsychopharmacology. 1999 May;20(5):480-90. [PubMed:10192828 ]
  4. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Weiss J, Dormann SM, Martin-Facklam M, Kerpen CJ, Ketabi-Kiyanvash N, Haefeli WE: Inhibition of P-glycoprotein by newer antidepressants. J Pharmacol Exp Ther. 2003 Apr;305(1):197-204. [PubMed:12649369 ]
  2. Uhr M, Grauer MT, Holsboer F: Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-glycoprotein gene disruption. Biol Psychiatry. 2003 Oct 15;54(8):840-6. [PubMed:14550684 ]
  3. Karlsson L, Schmitt U, Josefsson M, Carlsson B, Ahlner J, Bengtsson F, Kugelberg FC, Hiemke C: Blood-brain barrier penetration of the enantiomers of venlafaxine and its metabolites in mice lacking P-glycoprotein. Eur Neuropsychopharmacol. 2010 Sep;20(9):632-40. doi: 10.1016/j.euroneuro.2010.04.004. Epub 2010 May 13. [PubMed:20466523 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from t...
Gene Name:
ABCG2
Uniprot ID:
Q9UNQ0
Molecular Weight:
72313.47 Da
References
  1. Bachmeier CJ, Beaulieu-Abdelahad D, Ganey NJ, Mullan MJ, Levin GM: Induction of drug efflux protein expression by venlafaxine but not desvenlafaxine. Biopharm Drug Dispos. 2011 May;32(4):233-44. doi: 10.1002/bdd.753. Epub 2011 Mar 28. [PubMed:21446053 ]
Comments
comments powered by Disqus
Drug created on June 13, 2005 07:24 / Updated on July 25, 2016 03:10