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Identification
NameVenlafaxine
Accession NumberDB00285  (APRD00125)
TypeSmall Molecule
GroupsApproved
Description

Venlafaxine (Effexor) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class first introduced by Wyeth in 1993. It is prescribed for the treatment of clinical depression and anxiety disorders. Due to the pronounced side effects and suspicions that venlafaxine may significantly increase the risk of suicide it is not recommended as a first line treatment of depression. However, it is often effective for depression not responding to SSRIs. Venlafaxine was the sixth most widely-used antidepressant based on the amount of retail prescriptions in the US (17.1 million) in 2006. [Wikipedia]

Structure
Thumb
Synonyms
Elafax
Venlafaxina
Venlafaxine
Venlafaxinum
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Act Venlafaxine XRcapsule (extended release)37.5 mgoralActavis Pharma Company2008-02-13Not applicableCanada
Act Venlafaxine XRcapsule (extended release)150.0 mgoralActavis Pharma Company2008-02-13Not applicableCanada
Act Venlafaxine XRcapsule (extended release)75.0 mgoralActavis Pharma Company2008-02-13Not applicableCanada
Auro-venlafaxine XRcapsule (extended release)150 mgoralAuro Pharma Inc2016-03-14Not applicableCanada
Auro-venlafaxine XRcapsule (extended release)75 mgoralAuro Pharma Inc2016-03-14Not applicableCanada
Auro-venlafaxine XRcapsule (extended release)37.5 mgoralAuro Pharma Inc2016-03-14Not applicableCanada
Dom-venlafaxine XRcapsule (extended release)150 mgoralDominion Pharmacal2013-05-30Not applicableCanada
Dom-venlafaxine XRcapsule (extended release)75 mgoralDominion Pharmacal2013-05-23Not applicableCanada
Dom-venlafaxine XRcapsule (extended release)37.5 mgoralDominion Pharmacal2013-05-23Not applicableCanada
Effexor Tablets, 37.5mgtablet37.5 mgoralWyeth Canada1994-12-312004-08-19Canada
Effexor Tablets, 50mgtablet50 mgoralWyeth Canada1995-12-312004-08-19Canada
Effexor Tablets, 75mgtablet75 mgoralWyeth Canada1994-12-312004-08-19Canada
Effexor XRcapsule, extended release150 mg/1oralbryant ranch prepack1997-11-01Not applicableUs
Effexor XRcapsule, extended release75 mg/1oralWyeth Pharmaceuticals Inc., a subsidiary of Pfizer Inc.1997-11-01Not applicableUs
Effexor XRcapsule, extended release37.5 mg/1oralCardinal Health1997-11-01Not applicableUs
Effexor XRcapsule (extended release)37.5 mgoralPfizer Canada Inc1998-03-04Not applicableCanada
Effexor XRcapsule, extended release75 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-01-31Not applicableUs
Effexor XRcapsule, extended release37.5 mg/1oralPhysicians Total Care, Inc.2004-04-07Not applicableUs
Effexor XRcapsule, extended release75 mg/1oralPhysicians Total Care, Inc.2003-04-25Not applicableUs
Effexor XRcapsule, extended release150 mg/1oralPhysicians Total Care, Inc.2001-08-28Not applicableUs
Effexor XRcapsule, extended release150 mg/1oralStat Rx USA1997-11-01Not applicableUs
Effexor XRcapsule, extended release37.5 mg/1oralWyeth Pharmaceuticals Inc., a subsidiary of Pfizer Inc.1997-11-01Not applicableUs
Effexor XRcapsule, extended release75 mg/1oralPd Rx Pharmaceuticals, Inc.1997-11-01Not applicableUs
Effexor XRcapsule, extended release75 mg/1oralStat Rx USA1997-11-01Not applicableUs
Effexor XRcapsule (extended release)150 mgoralPfizer Canada Inc1998-03-04Not applicableCanada
Effexor XRcapsule, extended release75 mg/1oralCardinal Health1997-11-01Not applicableUs
Effexor XRcapsule, extended release150 mg/1oralWyeth Pharmaceuticals Inc., a subsidiary of Pfizer Inc.1997-11-01Not applicableUs
Effexor XRcapsule, extended release150 mg/1oralCardinal Health1997-11-01Not applicableUs
Effexor XRcapsule, extended release37.5 mg/1oralStat Rx USA1997-11-01Not applicableUs
Effexor XRcapsule (extended release)75 mgoralPfizer Canada Inc1998-03-04Not applicableCanada
Effexor XRcapsule, extended release150 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-05-25Not applicableUs
Effexor XR Extended-releasecapsule, extended release150 mg/1oralRebel Distributors Corp1997-11-01Not applicableUs
Effexor XR Extended-releasecapsule, extended release75 mg/1oralRebel Distributors Corp1997-11-01Not applicableUs
Effexor XR Extended-releasecapsule, extended release37.5 mg/1oralRebel Distributors Corp1997-11-01Not applicableUs
Effexor XR Extended-releasecapsule, extended release150 mg/1oralAphena Pharma Solutions Tennessee, Inc.1997-11-01Not applicableUs
Gd-venlafaxine XRcapsule (extended release)150 mgoralGenmed A Division Of Pfizer Canada Inc2011-10-28Not applicableCanada
Gd-venlafaxine XRcapsule (extended release)75 mgoralGenmed A Division Of Pfizer Canada Inc2011-10-28Not applicableCanada
Gd-venlafaxine XRcapsule (extended release)37.5 mgoralGenmed A Division Of Pfizer Canada Inc2011-10-28Not applicableCanada
Mylan-venlafaxine XRcapsule (extended release)75 mgoralMylan Pharmaceuticals Ulc2008-05-07Not applicableCanada
Mylan-venlafaxine XRcapsule (extended release)37.5 mgoralMylan Pharmaceuticals Ulc2008-05-07Not applicableCanada
Mylan-venlafaxine XRcapsule (extended release)150 mgoralMylan Pharmaceuticals Ulc2008-05-07Not applicableCanada
Ntp-venlafaxine XRcapsule (extended release)75 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-venlafaxine XRcapsule (extended release)37.5 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-venlafaxine XRcapsule (extended release)150 mgoralTeva Canada LimitedNot applicableNot applicableCanada
PHL-venlafaxine XRcapsule (extended release)37.5 mgoralPharmel IncNot applicableNot applicableCanada
PHL-venlafaxine XRcapsule (extended release)150 mgoralPharmel IncNot applicableNot applicableCanada
PHL-venlafaxine XRcapsule (extended release)75 mgoralPharmel IncNot applicableNot applicableCanada
PMS-venlafaxine XRcapsule (extended release)37.5 mgoralPharmascience Inc2007-08-17Not applicableCanada
PMS-venlafaxine XRcapsule (extended release)150 mgoralPharmascience Inc2007-08-17Not applicableCanada
PMS-venlafaxine XRcapsule (extended release)75 mgoralPharmascience Inc2007-08-17Not applicableCanada
Ran-venlafaxine XRcapsule (extended release)75 mgoralRanbaxy Pharmaceuticals Canada Inc.2012-02-17Not applicableCanada
Ran-venlafaxine XRcapsule (extended release)37.5 mgoralRanbaxy Pharmaceuticals Canada Inc.2012-02-17Not applicableCanada
Ran-venlafaxine XRcapsule (extended release)150 mgoralRanbaxy Pharmaceuticals Canada Inc.2012-02-16Not applicableCanada
Riva-venlafaxine XRcapsule (extended release)150 mgoralLaboratoire Riva Inc2008-05-22Not applicableCanada
Riva-venlafaxine XRcapsule (extended release)75 mgoralLaboratoire Riva Inc2008-05-22Not applicableCanada
Riva-venlafaxine XRcapsule (extended release)37.5 mgoralLaboratoire Riva Inc2008-05-22Not applicableCanada
Sandoz Venlafaxine XRcapsule (extended release)37.5 mgoralSandoz Canada Incorporated2008-05-09Not applicableCanada
Sandoz Venlafaxine XRcapsule (extended release)150.0 mgoralSandoz Canada Incorporated2008-05-09Not applicableCanada
Sandoz Venlafaxine XRcapsule (extended release)75.0 mgoralSandoz Canada Incorporated2008-05-09Not applicableCanada
Teva-venlafaxine XRcapsule (extended release)75 mgoralTeva Canada Limited2006-12-01Not applicableCanada
Teva-venlafaxine XRcapsule (extended release)37.5 mgoralTeva Canada Limited2006-12-01Not applicableCanada
Teva-venlafaxine XRcapsule (extended release)150 mgoralTeva Canada Limited2006-12-01Not applicableCanada
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralRebel Distributors Corp2011-06-10Not applicableUs
Venlafaxine Hydrochloridetablet, extended release37.5 mg/1oralPhysicians Total Care, Inc.2010-06-11Not applicableUs
Venlafaxine Hydrochloridetablet, film coated, extended release75 mg/1oralUpstate Pharma, LLC2008-10-10Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralRebel Distributors Corp2011-06-10Not applicableUs
Venlafaxine Hydrochloridetablet, extended release225 mg/1oralKremers Urban Pharmaceuticals Inc.2010-04-29Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralGreenstone LLC2011-06-02Not applicableUs
Venlafaxine Hydrochloridecapsule, delayed release75 mg/1oralDIRECT RX2015-01-01Not applicableUs
Venlafaxine Hydrochloridetablet, extended release150 mg/1oralKremers Urban Pharmaceuticals Inc.2010-04-29Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralGreenstone LLC2011-06-02Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralPreferred Pharmaceuticals, Inc.2014-04-18Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralREMEDYREPACK INC.2012-03-14Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralDIRECT RX2014-01-01Not applicableUs
Venlafaxine Hydrochloridetablet, extended release75 mg/1oralKremers Urban Pharmaceuticals Inc.2010-04-29Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralClinical Solutions Wholesale2011-06-10Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralCarilion Materials Management2011-06-02Not applicableUs
Venlafaxine Hydrochloridetablet, extended release75 mg/1oralREMEDYREPACK INC.2011-11-17Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralApotex Corp.2011-06-10Not applicableUs
Venlafaxine Hydrochloridetablet, extended release37.5 mg/1oralKremers Urban Pharmaceuticals Inc.2010-04-29Not applicableUs
Venlafaxine Hydrochloridetablet, extended release225 mg/1oralClinical Solutions Wholesale2010-04-29Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralMedsource Pharmaceuticals2011-06-10Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralApotex Corp.2011-06-10Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralCarilion Materials Management2011-06-02Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralREMEDYREPACK INC.2013-05-08Not applicableUs
Venlafaxine Hydrochloridetablet, film coated, extended release225 mg/1oralUpstate Pharma, LLC2008-10-17Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralMedsource Pharmaceuticals2011-06-10Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralApotex Corp.2011-06-10Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralUnit Dose Services2011-06-10Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralRebel Distributors Corp2011-06-10Not applicableUs
Venlafaxine Hydrochloridetablet, film coated, extended release37.5 mg/1oralUpstate Pharma, LLC2008-09-30Not applicableUs
Venlafaxine Hydrochloridetablet, film coated, extended release150 mg/1oralUpstate Pharma, LLC2008-10-10Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-06-10Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralGreenstone LLC2011-06-02Not applicableUs
Venlafaxine Hydrochloride Extended-release Capsulescapsule (extended release)37.5 mgoralDr Reddys Laboratories IncNot applicableNot applicableCanada
Venlafaxine Hydrochloride Extended-release Capsulescapsule (extended release)150 mgoralDr Reddys Laboratories IncNot applicableNot applicableCanada
Venlafaxine Hydrochloride Extended-release Capsulescapsule (extended release)75 mgoralDr Reddys Laboratories IncNot applicableNot applicableCanada
Venlafaxine XRcapsule (extended release)37.5 mgoralSivem Pharmaceuticals Ulc2012-06-10Not applicableCanada
Venlafaxine XRcapsule (extended release)37.5 mgoralSanis Health Inc2010-07-27Not applicableCanada
Venlafaxine XRcapsule (extended release)37.5 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Venlafaxine XRcapsule (extended release)150 mgoralPro Doc Limitee2010-02-03Not applicableCanada
Venlafaxine XRcapsule (extended release)150 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Venlafaxine XRcapsule (extended release)150 mgoralPharmascience Inc2007-08-02Not applicableCanada
Venlafaxine XRcapsule (extended release)150.0 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Venlafaxine XRcapsule (extended release)75 mgoralPro Doc Limitee2010-02-03Not applicableCanada
Venlafaxine XRcapsule (extended release)75 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Venlafaxine XRcapsule (extended release)75 mgoralPharmascience Inc2007-08-02Not applicableCanada
Venlafaxine XRcapsule (extended release)75.0 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Venlafaxine XRcapsule (extended release)37.5 mgoralPro Doc Limitee2010-02-03Not applicableCanada
Venlafaxine XRcapsule (extended release)37.5 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Venlafaxine XRcapsule (extended release)37.5 mgoralPharmascience Inc2007-08-02Not applicableCanada
Venlafaxine XRcapsule (extended release)37.5 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Venlafaxine XRcapsule (extended release)150 mgoralSivem Pharmaceuticals Ulc2012-06-10Not applicableCanada
Venlafaxine XRcapsule (extended release)150 mgoralSanis Health Inc2010-07-27Not applicableCanada
Venlafaxine XRcapsule (extended release)150 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Venlafaxine XRcapsule (extended release)75 mgoralSivem Pharmaceuticals Ulc2012-06-10Not applicableCanada
Venlafaxine XRcapsule (extended release)75 mgoralSanis Health Inc2010-07-27Not applicableCanada
Venlafaxine XRcapsule (extended release)75 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-venlafaxine XRcapsule (extended release)150.0 mgoralApotex Inc2013-04-16Not applicableCanada
Apo-venlafaxine XRcapsule (extended release)75.0 mgoralApotex Inc2013-04-16Not applicableCanada
Apo-venlafaxine XRcapsule (extended release)37.5 mgoralApotex Inc2013-04-16Not applicableCanada
Venlafaxinetablet37.5 mg/1oralTrigen Laboratories, LLC2010-12-21Not applicableUs
Venlafaxinetablet37.5 mg/1oralHeritage Pharmaceuticals Inc.2012-11-30Not applicableUs
Venlafaxinetablet100 mg/1oralClinical Solutions Wholesale2010-08-04Not applicableUs
Venlafaxinetablet75 mg/1oralDIRECT RX2015-01-01Not applicableUs
Venlafaxinetablet50 mg/1oralAurobindo Pharma Limited2010-04-07Not applicableUs
Venlafaxinetablet75 mg/1oralAmerican Health Packaging2015-02-15Not applicableUs
Venlafaxinetablet25 mg/1oralTrupharma, Llc2016-04-19Not applicableUs
Venlafaxinetablet50 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2008-06-13Not applicableUs
Venlafaxinetablet100 mg/1oralKAISER FOUNDATION HOSPITALS2014-09-03Not applicableUs
Venlafaxinetablet75 mg/1oralTrigen Laboratories, LLC2010-12-21Not applicableUs
Venlafaxinetablet75 mg/1oralHeritage Pharmaceuticals Inc.2012-11-30Not applicableUs
Venlafaxinetablet75 mg/1oralMylan Institutional Inc.2008-07-15Not applicableUs
Venlafaxinetablet37.5 mg/1oralClinical Solutions Wholesale2010-08-04Not applicableUs
Venlafaxinetablet100 mg/1oralAurobindo Pharma Limited2010-04-07Not applicableUs
Venlafaxinetablet50 mg/1oralAmerican Health Packaging2015-02-15Not applicableUs
Venlafaxinetablet50 mg/1oralTrupharma, Llc2016-04-19Not applicableUs
Venlafaxinetablet75 mg/1oralNorth Star Rx Llc2010-12-21Not applicableUs
Venlafaxinetablet50 mg/1oralSun Pharmaceutical Industries, Inc.2008-06-13Not applicableUs
Venlafaxinetablet75 mg/1oralAlembic Pharmaceuticals Inc.2015-10-01Not applicableUs
Venlafaxinetablet75 mg/1oralBlue Point Laboratories2013-11-25Not applicableUs
Venlafaxinetablet75 mg/1oralZydus Pharmaceuticals (USA) Inc.2008-06-13Not applicableUs
Venlafaxinetablet50 mg/1oralCitron Pharma LLC2010-04-07Not applicableUs
Venlafaxinetablet50 mg/1oralREMEDYREPACK INC.2013-05-29Not applicableUs
Venlafaxinetablet50 mg/1oralQualitest Pharmaceuticals2010-08-04Not applicableUs
Venlafaxinetablet25 mg/1oralTrigen Laboratories, LLC2010-12-21Not applicableUs
Venlafaxinetablet25 mg/1oralHeritage Pharmaceuticals Inc.2012-11-30Not applicableUs
Venlafaxinetablet75 mg/1oralPd Rx Pharmaceuticals, Inc.2008-06-13Not applicableUs
Venlafaxinetablet75 mg/1oralClinical Solutions Wholesale2010-08-04Not applicableUs
Venlafaxinetablet37.5 mg/1oralAurobindo Pharma Limited2010-04-07Not applicableUs
Venlafaxinetablet37.5 mg/1oralAmerican Health Packaging2015-02-15Not applicableUs
Venlafaxinetablet75 mg/1oralREMEDYREPACK INC.2016-01-25Not applicableUs
Venlafaxinetablet75 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2008-06-13Not applicableUs
Venlafaxinetablet50 mg/1oralKAISER FOUNDATION HOSPITALS2014-09-03Not applicableUs
Venlafaxinetablet50 mg/1oralNorth Star Rx Llc2010-12-21Not applicableUs
Venlafaxinetablet37.5 mg/1oralSun Pharmaceutical Industries, Inc.2008-06-13Not applicableUs
Venlafaxinetablet50 mg/1oralAlembic Pharmaceuticals Inc.2015-10-01Not applicableUs
Venlafaxinetablet50 mg/1oralbryant ranch prepack2012-11-30Not applicableUs
Venlafaxinetablet50 mg/1oralBlue Point Laboratories2013-11-25Not applicableUs
Venlafaxinetablet50 mg/1oralZydus Pharmaceuticals (USA) Inc.2008-06-13Not applicableUs
Venlafaxinetablet37.5 mg/1oralCitron Pharma LLC2010-04-07Not applicableUs
Venlafaxinetablet25 mg/1oralREMEDYREPACK INC.2013-05-28Not applicableUs
Venlafaxinetablet50 mg/1oralClinical Solutions Wholesale2010-08-04Not applicableUs
Venlafaxinetablet50 mg/1oralREMEDYREPACK INC.2015-10-27Not applicableUs
Venlafaxinetablet75 mg/1oralProficient Rx LP2008-06-13Not applicableUs
Venlafaxinetablet25 mg/1oralAurobindo Pharma Limited2010-04-07Not applicableUs
Venlafaxinetablet37.5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2008-06-13Not applicableUs
Venlafaxinetablet25 mg/1oralKAISER FOUNDATION HOSPITALS2014-09-03Not applicableUs
Venlafaxinetablet37.5 mg/1oralNorth Star Rx Llc2010-12-21Not applicableUs
Venlafaxinetablet25 mg/1oralSun Pharmaceutical Industries, Inc.2008-06-13Not applicableUs
Venlafaxinetablet37.5 mg/1oralAlembic Pharmaceuticals Inc.2015-10-01Not applicableUs
Venlafaxinetablet37.5 mg/1oralBlue Point Laboratories2013-11-25Not applicableUs
Venlafaxinetablet37.5 mg/1oralZydus Pharmaceuticals (USA) Inc.2008-06-13Not applicableUs
Venlafaxinetablet25 mg/1oralCitron Pharma LLC2010-04-07Not applicableUs
Venlafaxinetablet75 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Venlafaxinetablet37.5 mg/1oralREMEDYREPACK INC.2015-10-19Not applicableUs
Venlafaxinetablet100 mg/1oralZydus Pharmaceuticals (USA) Inc.2008-06-13Not applicableUs
Venlafaxinetablet37.5 mg/1oralQualitest Pharmaceuticals2010-08-04Not applicableUs
Venlafaxinetablet25 mg/1oralNorth Star Rx Llc2010-12-21Not applicableUs
Venlafaxinetablet75 mg/1oralAidarex Pharmaceuticals LLC2012-11-30Not applicableUs
Venlafaxinetablet100 mg/1oralREMEDYREPACK INC.2014-02-19Not applicableUs
Venlafaxinetablet25 mg/1oralAlembic Pharmaceuticals Inc.2015-10-01Not applicableUs
Venlafaxinetablet25 mg/1oralBlue Point Laboratories2013-11-25Not applicableUs
Venlafaxinetablet25 mg/1oralZydus Pharmaceuticals (USA) Inc.2008-06-13Not applicableUs
Venlafaxinetablet100 mg/1oralREMEDYREPACK INC.2015-10-09Not applicableUs
Venlafaxinetablet25 mg/1oralQualitest Pharmaceuticals2010-08-04Not applicableUs
Venlafaxinetablet37.5 mg/1oralAidarex Pharmaceuticals LLC2012-11-30Not applicableUs
Venlafaxinetablet37.5 mg/1oralDIRECT RX2015-01-01Not applicableUs
Venlafaxinetablet100 mg/1oralBlue Point Laboratories2013-11-25Not applicableUs
Venlafaxinetablet100 mg/1oralTrupharma, Llc2016-04-19Not applicableUs
Venlafaxinetablet100 mg/1oralSun Pharmaceutical Industries, Inc.2008-06-13Not applicableUs
Venlafaxinetablet25 mg/1oralREMEDYREPACK INC.2015-10-08Not applicableUs
Venlafaxinetablet100 mg/1oralCitron Pharma LLC2010-04-07Not applicableUs
Venlafaxinetablet37.5 mg/1oralREMEDYREPACK INC.2013-05-29Not applicableUs
Venlafaxinetablet100 mg/1oralQualitest Pharmaceuticals2010-08-04Not applicableUs
Venlafaxinetablet50 mg/1oralTrigen Laboratories, LLC2010-12-21Not applicableUs
Venlafaxinetablet50 mg/1oralHeritage Pharmaceuticals Inc.2012-11-30Not applicableUs
Venlafaxinetablet37.5 mg/1oralMylan Institutional Inc.2008-07-15Not applicableUs
Venlafaxinetablet25 mg/1oralClinical Solutions Wholesale2010-08-04Not applicableUs
Venlafaxinetablet75 mg/1oralDIRECT RX2014-01-01Not applicableUs
Venlafaxinetablet75 mg/1oralAurobindo Pharma Limited2010-04-07Not applicableUs
Venlafaxinetablet25 mg/1oralAmerican Health Packaging2015-02-15Not applicableUs
Venlafaxinetablet37.5 mg/1oralTrupharma, Llc2016-04-19Not applicableUs
Venlafaxinetablet100 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2008-06-13Not applicableUs
Venlafaxinetablet100 mg/1oralTrigen Laboratories, LLC2010-12-21Not applicableUs
Venlafaxinetablet100 mg/1oralHeritage Pharmaceuticals Inc.2012-11-30Not applicableUs
Venlafaxinetablet50 mg/1oralDIRECT RX2014-01-01Not applicableUs
Venlafaxinetablet100 mg/1oralAmerican Health Packaging2015-02-15Not applicableUs
Venlafaxinetablet75 mg/1oralTrupharma, Llc2016-04-19Not applicableUs
Venlafaxinetablet100 mg/1oralNorth Star Rx Llc2010-12-21Not applicableUs
Venlafaxinetablet75 mg/1oralSun Pharmaceutical Industries, Inc.2008-06-13Not applicableUs
Venlafaxinetablet75 mg/1oralREMEDYREPACK INC.2015-10-08Not applicableUs
Venlafaxinetablet100 mg/1oralAlembic Pharmaceuticals Inc.2015-10-01Not applicableUs
Venlafaxinetablet75 mg/1oralCitron Pharma LLC2010-04-07Not applicableUs
Venlafaxinetablet75 mg/1oralREMEDYREPACK INC.2013-05-29Not applicableUs
Venlafaxinetablet75 mg/1oralQualitest Pharmaceuticals2010-08-04Not applicableUs
Venlafaxine Hydrochloridetablet, extended release37.5 mg/1oralSun Pharma Global Inc.2010-08-18Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralAphena Pharma Solutions Tennessee, Llc2010-08-04Not applicableUs
Venlafaxine Hydrochloridetablet, extended release75 mg/1oralREMEDYREPACK INC.2013-04-11Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralPhysicians Total Care, Inc.2010-11-08Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralCardinal Health2011-06-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralProficient Rx LP2010-07-01Not applicableUs
Venlafaxine Hydrochloridetablet25 mg/1oralAmneal Pharmaceuticals of New York, LLC2010-05-11Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralOrchid Healthcare (a division of Orchid Chemicals & Pharmaceuticals Ltd.)2012-07-07Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralAvera Mc Kennan Hospital2015-07-27Not applicableUs
Venlafaxine Hydrochloridetablet25 mg/1oralTeva Pharmaceuticals USA Inc2006-08-04Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-06-28Not applicableUs
Venlafaxine Hydrochloridetablet100 mg/1oralRebel Distributors Corp2008-06-13Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralAphena Pharma Solutions Tennessee, Llc2012-05-07Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralPhysicians Total Care, Inc.2010-11-08Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralWockhardt Limited2011-04-14Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralDIRECT RX2014-01-01Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralbryant ranch prepack2008-06-13Not applicableUs
Venlafaxine Hydrochloridetablet100 mg/1oralAmneal Pharmaceuticals of New York, LLC2010-05-11Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralAmerican Health Packaging2011-06-012015-12-31Us
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralClinical Solutions Wholesale, Llc2011-06-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralKAISER FOUNDATION HOSPITALS2014-10-27Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralTeva Pharmaceuticals USA Inc2010-07-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralMajor Pharmaceuticals2015-04-06Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralRx Change Co.2014-11-27Not applicableUs
Venlafaxine Hydrochloridetablet100 mg/1oralAv Kare, Inc.2012-05-07Not applicableUs
Venlafaxine Hydrochloridetablet, extended release37.5 mg/1oralSun Pharma Global FZE2014-12-15Not applicableUs
Venlafaxine Hydrochloridetablet100 mg/1oralREMEDYREPACK INC.2014-03-24Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralDr. Reddy's Laboratories Limited2008-06-16Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralREMEDYREPACK INC.2015-05-30Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2012-10-15Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralCadila Healthcare Limited2008-06-13Not applicableUs
Venlafaxine Hydrochloridetablet, extended release75 mg/1oralSun Pharma Global Inc.2010-08-18Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralREMEDYREPACK INC.2011-08-05Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralPhysicians Total Care, Inc.2007-02-02Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralCardinal Health2011-06-01Not applicableUs
Venlafaxine Hydrochloridecapsule, coated, extended release75 mg/1oralDIRECT RX2014-01-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralProficient Rx LP2010-07-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralTYA Pharmaceuticals2011-06-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralOrchid Healthcare (a division of Orchid Chemicals & Pharmaceuticals Ltd.)2012-07-07Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralUnit Dose Services2010-07-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralMajor Pharmaceuticals2011-06-07Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralAidarex Pharmaceuticals LLC2010-07-01Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralAv Kare, Inc.2012-05-07Not applicableUs
Venlafaxine Hydrochloridetablet, extended release75 mg/1oralSun Pharma Global FZE2014-12-15Not applicableUs
Venlafaxine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2014-03-11Not applicableUs
Venlafaxine Hydrochloridetablet25 mg/1oralDr. Reddy's Laboratories Limited2008-06-16Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralREMEDYREPACK INC.2015-03-27Not applicableUs
Venlafaxine Hydrochloridetablet50 mg/1oralCadila Healthcare Limited2008-06-13Not applicableUs
Venlafaxine Hydrochloridetablet100 mg/1oralMylan Pharmaceuticals Inc.2008-06-14Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralTeva Pharmaceuticals USA Inc2010-07-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralTorrent Pharmaceuticals Limited2011-01-06Not applicableUs
Venlafaxine Hydrochloridetablet100 mg/1oralRebel Distributors Corp.2009-09-03Not applicableUs
Venlafaxine Hydrochloridetablet, extended release150 mg/1oralSun Pharma Global Inc.2010-08-18Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralPd Rx Pharmaceuticals, Inc.2011-06-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralREMEDYREPACK INC.2011-08-04Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralPhysicians Total Care, Inc.2007-07-19Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralCardinal Health2011-06-07Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralTYA Pharmaceuticals2011-06-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralAmerican Health Packaging2014-02-03Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralPreferred Pharmaceuticals Inc.2015-09-11Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralAurobindo Pharma Limited2011-11-23Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralMajor Pharmaceuticals2011-06-07Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralAidarex Pharmaceuticals LLC2010-07-01Not applicableUs
Venlafaxine Hydrochloridetablet50 mg/1oralAv Kare, Inc.2012-05-07Not applicableUs
Venlafaxine Hydrochloridetablet, extended release150 mg/1oralSun Pharma Global FZE2014-12-15Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralREMEDYREPACK INC.2014-03-11Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralDr.Reddy's laboratories Ltd.2011-06-01Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralSt. Marys Medical Park Pharmacy2011-01-30Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralbryant ranch prepack2010-07-01Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralCadila Healthcare Limited2008-06-13Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralClinical Solutions Wholesale, Llc2010-07-01Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralMylan Pharmaceuticals Inc.2008-06-14Not applicableUs
Venlafaxine Hydrochloridetablet100 mg/1oralTeva Pharmaceuticals USA Inc2006-08-04Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralTorrent Pharmaceuticals Limited2011-01-06Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralRebel Distributors Corp.2009-09-03Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-06-01Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralPd Rx Pharmaceuticals, Inc.2009-11-27Not applicableUs
Venlafaxine Hydrochloridetablet50 mg/1oralREMEDYREPACK INC.2011-05-02Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralCardinal Health2011-06-07Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralClinical Solutions Wholesale, Llc2006-08-04Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralProficient Rx LP2011-06-10Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralWockhardt USA LLC.2011-04-14Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralCadila Healthcare Limited2011-06-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralAmerican Health Packaging2014-02-03Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralAurobindo Pharma Limited2011-06-01Not applicableUs
Venlafaxine Hydrochloridetablet100 mg/1oralKAISER FOUNDATION HOSPITALS2012-01-05Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralMajor Pharmaceuticals2011-06-07Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralAv Kare, Inc.2012-05-07Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralAphena Pharma Solutions Tennessee, Llc2013-06-12Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralDr.Reddy's laboratories Ltd.2011-06-01Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-08-04Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralGolden State Medical Supply, Inc2013-06-12Not applicableUs
Venlafaxine Hydrochloridetablet100 mg/1oralbryant ranch prepack2010-05-11Not applicableUs
Venlafaxine Hydrochloridetablet25 mg/1oralCadila Healthcare Limited2008-06-13Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralREMEDYREPACK INC.2016-01-11Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralClinical Solutions Wholesale, Llc2010-07-01Not applicableUs
Venlafaxine Hydrochloridetablet50 mg/1oralMylan Pharmaceuticals Inc.2008-06-14Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralTeva Pharmaceuticals USA Inc2006-08-04Not applicableUs
Venlafaxine Hydrochloridetablet50 mg/1oralKAISER FOUNDATION HOSPITALS2012-01-05Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralTorrent Pharmaceuticals Limited2011-01-06Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralRebel Distributors Corp.2009-09-03Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-07-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralAv Kare, Inc.2013-07-10Not applicableUs
Venlafaxine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2011-04-25Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralH.J. Harkins Company, Inc.2008-06-13Not applicableUs
Venlafaxine Hydrochloridetablet100 mg/1oralDr. Reddy's Laboratories Limited2008-06-16Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralClinical Solutions Wholesale, Llc2006-08-04Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralProficient Rx LP2011-06-10Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralWockhardt USA LLC.2011-04-14Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralCadila Healthcare Limited2011-06-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralAmerican Health Packaging2014-02-03Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralZydus Pharmaceuticals (USA) Inc.2011-06-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralAurobindo Pharma Limited2011-06-01Not applicableUs
Venlafaxine Hydrochloridetablet50 mg/1oralTeva Pharmaceuticals USA Inc2006-08-04Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-07-01Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralSTAT Rx USA LLC2009-11-27Not applicableUs
Venlafaxine Hydrochloridetablet25 mg/1oralAv Kare, Inc.2012-05-07Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralAphena Pharma Solutions Tennessee, Llc2013-06-12Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralREMEDYREPACK INC.2013-05-03Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralDr.Reddy's laboratories Ltd.2011-06-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralWockhardt Limited2011-04-14Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralGolden State Medical Supply, Inc2013-06-12Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralbryant ranch prepack2010-07-01Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralAmneal Pharmaceuticals of New York, LLC2010-05-11Not applicableUs
Venlafaxine Hydrochloridetablet25 mg/1oralCarilion Materials Management2006-08-04Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralAmerican Health Packaging2011-06-012015-12-31Us
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralClinical Solutions Wholesale, Llc2010-07-01Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralMylan Pharmaceuticals Inc.2008-06-14Not applicableUs
Venlafaxine Hydrochloridetablet25 mg/1oralKAISER FOUNDATION HOSPITALS2012-01-05Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralMajor Pharmaceuticals2015-04-06Not applicableUs
Venlafaxine Hydrochloridetablet25 mg/1oralRebel Distributors Corp.2009-09-03Not applicableUs
Venlafaxine Hydrochloridetablet, extended release75 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-12-06Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralAv Kare, Inc.2013-07-10Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralREMEDYREPACK INC.2010-11-23Not applicableUs
Venlafaxine Hydrochloridetablet100 mg/1oralREMEDYREPACK INC.2014-04-15Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralDr. Reddy's Laboratories Limited2008-06-16Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralProficient Rx LP2010-07-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralWockhardt USA LLC.2011-04-14Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralCadila Healthcare Limited2011-06-01Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralAmerican Health Packaging2009-01-13Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralZydus Pharmaceuticals (USA) Inc.2011-06-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralKAISER FOUNDATION HOSPITALS2014-10-27Not applicableUs
Venlafaxine Hydrochloridetablet25 mg/1oralRebel Distributors Corp2008-06-13Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralAphena Pharma Solutions Tennessee, Llc2010-08-04Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralPhysicians Total Care, Inc.2010-08-02Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralCardinal Health2011-06-01Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralbryant ranch prepack2010-05-11Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralAmneal Pharmaceuticals of New York, LLC2010-05-11Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralOrchid Healthcare (a division of Orchid Chemicals & Pharmaceuticals Ltd.)2012-07-07Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralClinical Solutions Wholesale, Llc2011-06-01Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralTeva Pharmaceuticals USA Inc2006-08-04Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-07-01Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralRebel Distributors Corp2008-06-13Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralAphena Pharma Solutions Tennessee, Llc2012-05-07Not applicableUs
Venlafaxine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2013-02-20Not applicableUs
Venlafaxine Hydrochloridetablet100 mg/1oralPhysicians Total Care, Inc.2011-04-22Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralWockhardt Limited2011-04-14Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralGolden State Medical Supply, Inc2013-06-12Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralbryant ranch prepack2010-06-28Not applicableUs
Venlafaxine Hydrochloridetablet50 mg/1oralAmneal Pharmaceuticals of New York, LLC2010-05-11Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralMed Vantx, Inc.2010-07-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralAmerican Health Packaging2011-06-012015-12-31Us
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralClinical Solutions Wholesale, Llc2011-11-23Not applicableUs
Venlafaxine Hydrochloridetablet25 mg/1oralMylan Pharmaceuticals Inc.2008-06-14Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralTeva Pharmaceuticals USA Inc2010-07-01Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release75 mg/1oralMajor Pharmaceuticals2015-04-06Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralLake Erie Medical DBA Quality Care Products LLC2008-06-13Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralAv Kare, Inc.2013-07-10Not applicableUs
Venlafaxine Hydrochloridetablet75 mg/1oralREMEDYREPACK INC.2013-05-14Not applicableUs
Venlafaxine Hydrochloridetablet50 mg/1oralREMEDYREPACK INC.2014-04-09Not applicableUs
Venlafaxine Hydrochloridetablet50 mg/1oralDr. Reddy's Laboratories Limited2008-06-16Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release150 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2014-05-27Not applicableUs
Venlafaxine Hydrochloridetablet100 mg/1oralCadila Healthcare Limited2008-06-13Not applicableUs
Venlafaxine Hydrochloridetablet37.5 mg/1oralAmerican Health Packaging2009-01-13Not applicableUs
Venlafaxine Hydrochloridecapsule, extended release37.5 mg/1oralZydus Pharmaceuticals (USA) Inc.2011-06-01Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
EffexorNot Available
ElafaxNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Venlafaxine Hydrochloride
Thumb
  • InChI Key: QYRYFNHXARDNFZ-UHFFFAOYNA-N
  • Monoisotopic Mass: 313.180856852
  • Average Mass: 313.863
DBSALT000186
Categories
UNIIGRZ5RCB1QG
CAS number93413-69-5
WeightAverage: 277.4018
Monoisotopic: 277.204179113
Chemical FormulaC17H27NO2
InChI KeyInChIKey=PNVNVHUZROJLTJ-UHFFFAOYSA-N
InChI
InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3
IUPAC Name
1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol
SMILES
COC1=CC=C(C=C1)C(CN(C)C)C1(O)CCCCC1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenylpropylamines. These are compounds containing a phenylpropylamine moiety, which consists of a phenyl group substituted at the third carbon by an propan-1-amine.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassPhenylpropylamines
Direct ParentPhenylpropylamines
Alternative Parents
Substituents
  • Phenylpropylamine
  • Methoxybenzene
  • Phenol ether
  • Anisole
  • Aralkylamine
  • Cyclohexanol
  • Alkyl aryl ether
  • Tertiary alcohol
  • Cyclic alcohol
  • 1,3-aminoalcohol
  • Tertiary aliphatic amine
  • Tertiary amine
  • Ether
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Alcohol
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor the management of major depressive disorder (MDD), generalized anxiety disorder (GAD), social anxiety disorder (social phobia), panic disorder with or without agoraphobia, vasomotor symptoms in women with breast cancer and in postmenopausal women, and neuropathic pain.
PharmacodynamicsVenlafaxine potentiates the neurotransmitter activity in the central nervous system. Furthermore, venlafaxine and its metabolite, O-desmethylvenlafaxine (ODV) potently inhibit the reuptake of serotonin and norepinephrine and weakly inhibit dopamine reuptake. Both molecules do not bind to muscarinic, histaminergic, or alpha-1 adrenergic receptors. Pharmacologic activity at these receptors is hypothesized to be associated with the various anticholinergic, sedative, and cardiovascular effects seen with other psychotropic drugs. Both also do not have any monoamine oxidase (MAO) inhibitory activity.
Mechanism of actionThe exact mechanism of action of venlafaxine is unknown, but appears to be associated with the its potentiation of neurotransmitter activity in the CNS. Venlafaxine and its active metabolite, O-desmethylvenlafaxine (ODV), inhibit the reuptake of both serotonin and norepinephrine with a potency greater for the 5-HT than for the NE reuptake process. Both venlafaxine and the ODV metabolite have weak inhibitory effects on the reuptake of dopamine but, unlike the tricyclics and similar to SSRIs, they are not active at histaminergic, muscarinic, or alpha(1)-adrenergic receptors.
Related Articles
AbsorptionVenlafaxine is well absorbed. Food does not effect the absorption of venlafaxine or its subsequent metabolism into ODV. Bioavailability is 45% following oral administration. Time to steady state = 3 days.
Volume of distribution
  • 7.5 ± 3.7 L/kg [venlafaxine]
  • 5.7 ± 1.8 L/kg [O-desmethylvenlafaxine(active metabolite)]
Protein bindingThe degree of binding of venlafaxine to human plasma is 27% ± 2% at concentrations ranging from 2.5 to 2215 ng/mL. The degree of ODV binding to human plasma is 30% ± 12% at concentrations ranging from 100 to 500 ng/mL. Protein-binding-induced drug interactions with venlafaxine are not expected.
Metabolism

Undergoes extensive first pass metabolism in the liver to its major, active metabolite, ODV, and two minor, less active metabolites, N-desmethylvenlafaxine and N,O-didesmethylvenlafaxine. Formation of ODV is catalyzed by cytochrome P450 (CYP) 2D6, whereas N-demethylation is catalyzed by CYP3A4, 2C19 and 2C9. ODV possesses antidepressant activity that is comparable to that of venlfaxine.

SubstrateEnzymesProduct
Venlafaxine
O-DesmethylvenlafaxineDetails
Venlafaxine
N-DesmethylvenlafaxineDetails
O-Desmethylvenlafaxine
N,O-DidesmethylvenlafaxineDetails
N,O-Didesmethylvenlafaxine
Not Available
N,O-didesmethylvenlafaxine glucuronideDetails
N,O-Didesmethylvenlafaxine
Not Available
N,N,O-TridesmethylvenlafaxineDetails
O-Desmethylvenlafaxine
Not Available
O-Desmethylvenlafaxine glucuronideDetails
N-Desmethylvenlafaxine
N,O-DidesmethylvenlafaxineDetails
Route of eliminationRenal elimination of venlafaxine and its metabolites is the primary route of excretion. Approximately 87% of a venlafaxine dose is recovered in the urine within 48 hours as either unchanged venlafaxine (5%), unconjugated ODV (29%), conjugated ODV (26%), or other minor inactive metabolites (27%).
Half life5 hours
Clearance

Steady state plasma clearance, venlafaxine = 1.3 ± 0.6 L/h/kg;
Steady state plasma clearance, ODV = 0.4 ± 0.2 L/h/kg.

ToxicityMost patients overdosing with venlafaxine develop only mild symptoms. However, severe toxicity is reported with the most common symptoms being CNS depression, serotonin toxicity, seizure, or cardiac conduction abnormalities. Venlafaxine's toxicity appears to be higher than other SSRIs, with a fatal toxic dose closer to that of the tricyclic antidepressants than the SSRIs. Doses of 900 mg or more are likely to cause moderate toxicity. Deaths have been reported following large doses.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Venlafaxine Metabolism PathwayDrug metabolismSMP00636
SNP Mediated Effects
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeEffectReference(s)
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
Not AvailableCYP2D6*4A AllelePoor drug metabolizer, lower dose requirements, nausea, vomiting and diarrhea16958828
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
rs5030655 CYP2D6*6T deletionPoor drug metabolizer, lower dose requirements, nausea, vomiting and diarrhea16958828
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
rs5030655 CYP2D6*6T deletion, homozygotePoor drug metabolizer, lower dose requirements, nausea, vomiting and diarrhea16958828
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
Not AvailableCYP2D6*5DeletionPoor drug metabolizer, lower dose requirements, nausea, vomiting and diarrhea16958828
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
rs3892097 CYP2D6*4A AllelePoor drug metabolizer, lower dose requirements, nausea, vomiting and diarrhea16958828
Multidrug resistance protein 1
Gene symbol: ABCB1
UniProt: P08183
rs2032583 Not AvailableC AlleleImproved response to antidepressant medication17913323
Multidrug resistance protein 1
Gene symbol: ABCB1
UniProt: P08183
rs2032583 Not AvailableA > GIncrease risk of adverse effects22641028
SNP Mediated Adverse Drug Reactions
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeAdverse ReactionReference(s)
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
rs5030655 CYP2D6*4del T alleleNausea, vomiting diarrhea16958828
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
rs3892097 CYP2D6*6A alleleNausea, vomiting diarrhea16958828
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9782
Blood Brain Barrier+0.9382
Caco-2 permeable+0.852
P-glycoprotein substrateSubstrate0.6534
P-glycoprotein inhibitor IInhibitor0.7031
P-glycoprotein inhibitor IIInhibitor0.8031
Renal organic cation transporterNon-inhibitor0.5792
CYP450 2C9 substrateNon-substrate0.7583
CYP450 2D6 substrateSubstrate0.8919
CYP450 3A4 substrateSubstrate0.7407
CYP450 1A2 substrateNon-inhibitor0.7664
CYP450 2C9 inhibitorNon-inhibitor0.6876
CYP450 2D6 inhibitorInhibitor0.7287
CYP450 2C19 inhibitorNon-inhibitor0.7199
CYP450 3A4 inhibitorNon-inhibitor0.8308
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8666
Ames testNon AMES toxic0.8
CarcinogenicityNon-carcinogens0.6762
BiodegradationNot ready biodegradable0.9941
Rat acute toxicity2.5404 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.5486
hERG inhibition (predictor II)Inhibitor0.6627
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Wyeth pharmaceuticals inc
  • Teva pharmaceuticals usa inc
  • Osmotica pharmaceutical corp
  • Actavis totowa llc
  • Amneal pharmaceuticals
  • Aurobindo pharma ltd
  • Caraco pharmaceutical laboratories ltd
  • Dr reddys laboratories ltd
  • Mylan pharmaceuticals inc
  • Pliva hrvatska doo
  • Sandoz inc
  • Vintage pharmaceuticals llc
  • Zydus pharmaceuticals usa inc
  • Wyeth
Packagers
Dosage forms
FormRouteStrength
Capsule (extended release)oral150.0 mg
Capsule (extended release)oral75.0 mg
Tabletoral37.5 mg
Tabletoral50 mg
Tabletoral75 mg
Capsule (extended release)oral150 mg
Capsule (extended release)oral37.5 mg
Capsule (extended release)oral75 mg
Capsule, extended releaseoral150 mg/1
Capsule, extended releaseoral37.5 mg/1
Capsule, extended releaseoral75 mg/1
Capsule, coated, extended releaseoral75 mg/1
Capsule, delayed releaseoral75 mg/1
Tabletoral100 mg/1
Tabletoral25 mg/1
Tabletoral37.5 mg/1
Tabletoral50 mg/1
Tabletoral75 mg/1
Tablet, extended releaseoral150 mg/1
Tablet, extended releaseoral225 mg/1
Tablet, extended releaseoral37.5 mg/1
Tablet, extended releaseoral75 mg/1
Tablet, film coated, extended releaseoral150 mg/1
Tablet, film coated, extended releaseoral225 mg/1
Tablet, film coated, extended releaseoral37.5 mg/1
Tablet, film coated, extended releaseoral75 mg/1
Prices
Unit descriptionCostUnit
Venlafaxine HCl 30 225 mg 24 Hour tablet Bottle276.98USD bottle
Effexor XR 30 37.5 mg 24 Hour Capsule Bottle144.33USD bottle
Venlafaxine HCl 30 37.5 mg 24 Hour tablet Bottle114.46USD bottle
Effexor 30 75 mg tablet Bottle87.83USD bottle
Effexor 30 25 mg tablet Bottle74.82USD bottle
Effexor XR 150 mg 24 Hour Capsule5.87USD capsule
Effexor xr 150 mg capsule5.65USD capsule
Effexor XR 75 mg 24 Hour Capsule5.39USD capsule
Effexor xr 75 mg capsule4.76USD capsule
Venlafaxine HCl 150 mg 24 Hour tablet4.72USD tablet
Effexor xr 37.5 mg capsule4.63USD capsule
Venlafaxine HCl 75 mg 24 Hour tablet4.42USD tablet
Effexor 100 mg tablet2.92USD tablet
Effexor 75 mg tablet2.7USD tablet
Effexor 50 mg tablet2.6USD tablet
Effexor 37.5 mg tablet2.5USD tablet
Effexor 25 mg tablet2.4USD tablet
Venlafaxine hcl 100 mg tablet2.36USD tablet
Venlafaxine hcl 75 mg tablet2.23USD tablet
Effexor Xr 150 mg Extended-Release Capsule2.16USD capsule
Venlafaxine hcl 50 mg tablet2.1USD tablet
Effexor Xr 75 mg Extended-Release Capsule2.05USD capsule
Venlafaxine hcl 37.5 mg tablet2.04USD tablet
Venlafaxine hcl 25 mg tablet1.98USD tablet
Apo-Venlafaxine Xr 150 mg Extended-Release Capsule1.2USD capsule
Co Venlafaxine Xr 150 mg Extended-Release Capsule1.2USD capsule
Mylan-Venlafaxine Xr 150 mg Extended-Release Capsule1.2USD capsule
Novo-Venlafaxine Xr 150 mg Extended-Release Capsule1.2USD capsule
Pms-Venlafaxine Xr 150 mg Extended-Release Capsule1.2USD capsule
Ratio-Venlafaxine Xr 150 mg Extended-Release Capsule1.2USD capsule
Sandoz Venlafaxine Xr 150 mg Extended-Release Capsule1.2USD capsule
Apo-Venlafaxine Xr 75 mg Extended-Release Capsule1.14USD capsule
Co Venlafaxine Xr 75 mg Extended-Release Capsule1.14USD capsule
Mylan-Venlafaxine Xr 75 mg Extended-Release Capsule1.14USD capsule
Novo-Venlafaxine Xr 75 mg Extended-Release Capsule1.14USD capsule
Pms-Venlafaxine Xr 75 mg Extended-Release Capsule1.14USD capsule
Ratio-Venlafaxine Xr 75 mg Extended-Release Capsule1.14USD capsule
Sandoz Venlafaxine Xr 75 mg Extended-Release Capsule1.14USD capsule
Effexor Xr 37.5 mg Extended-Release Capsule1.02USD capsule
Apo-Venlafaxine Xr 37.5 mg Extended-Release Capsule0.57USD capsule
Co Venlafaxine Xr 37.5 mg Extended-Release Capsule0.57USD capsule
Mylan-Venlafaxine Xr 37.5 mg Extended-Release Capsule0.57USD capsule
Novo-Venlafaxine Xr 37.5 mg Extended-Release Capsule0.57USD capsule
Pms-Venlafaxine Xr 37.5 mg Extended-Release Capsule0.57USD capsule
Ratio-Venlafaxine Xr 37.5 mg Extended-Release Capsule0.57USD capsule
Sandoz Venlafaxine Xr 37.5 mg Extended-Release Capsule0.57USD capsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2126305 No2006-10-172014-06-20Canada
CA2199778 No2005-12-202017-03-12Canada
US5916923 No1993-06-282013-06-28Us
US6274171 Yes1997-09-202017-09-20Us
US6403120 Yes1997-09-202017-09-20Us
US6419958 Yes1997-09-202017-09-20Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point215-217 °C (Hydrochloride salt)Not Available
water solubility572 mg/ml (Hydrochloride salt)Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.23 mg/mLALOGPS
logP2.69ALOGPS
logP2.74ChemAxon
logS-3.1ALOGPS
pKa (Strongest Acidic)14.42ChemAxon
pKa (Strongest Basic)8.91ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area32.7 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity83.02 m3·mol-1ChemAxon
Polarizability32.33 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
Synthesis Reference

Thomas P. Jerussi, Chrisantha H. Senanayake, “Derivatives of (+)-venlafaxine and methods of preparing and using the same.” U.S. Patent US6197828, issued June, 1994.

US6197828
General References
  1. Golden RN, Nicholas L: Antidepressant efficacy of venlafaxine. Depress Anxiety. 2000;12 Suppl 1:45-9. [PubMed:11098413 ]
  2. Thase ME, Clayton AH, Haight BR, Thompson AH, Modell JG, Johnston JA: A double-blind comparison between bupropion XL and venlafaxine XR: sexual functioning, antidepressant efficacy, and tolerability. J Clin Psychopharmacol. 2006 Oct;26(5):482-8. [PubMed:16974189 ]
  3. Bielski RJ, Ventura D, Chang CC: A double-blind comparison of escitalopram and venlafaxine extended release in the treatment of major depressive disorder. J Clin Psychiatry. 2004 Sep;65(9):1190-6. [PubMed:15367045 ]
  4. Rowbotham MC, Goli V, Kunz NR, Lei D: Venlafaxine extended release in the treatment of painful diabetic neuropathy: a double-blind, placebo-controlled study. Pain. 2004 Aug;110(3):697-706. [PubMed:15288411 ]
  5. Ozyalcin SN, Talu GK, Kiziltan E, Yucel B, Ertas M, Disci R: The efficacy and safety of venlafaxine in the prophylaxis of migraine. Headache. 2005 Feb;45(2):144-52. [PubMed:15705120 ]
  6. Whirl-Carrillo M, McDonagh EM, Hebert JM, Gong L, Sangkuhl K, Thorn CF, Altman RB, Klein TE: Pharmacogenomics knowledge for personalized medicine. Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96. [PubMed:22992668 ]
  7. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
External Links
ATC CodesN06AX16
AHFS Codes
  • 28:16.04.92
PDB EntriesNot Available
FDA labelDownload (3.38 MB)
MSDSDownload (36.5 KB)
Interactions
Drug Interactions
Drug
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Venlafaxine.
7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE may increase the serotonergic activities of Venlafaxine.
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Venlafaxine.
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Venlafaxine.
AcenocoumarolThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Acenocoumarol.
AcepromazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Acepromazine.
AceprometazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Aceprometazine.
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Venlafaxine.
AcetaminophenThe serum concentration of Venlafaxine can be increased when it is combined with Acetaminophen.
AcetophenazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Acetophenazine.
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Venlafaxine.
Acetylsalicylic acidVenlafaxine may increase the antiplatelet activities of Acetylsalicylic acid.
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Venlafaxine.
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Venlafaxine.
AgmatineVenlafaxine may decrease the antihypertensive activities of Agmatine.
AjmalineThe metabolism of Ajmaline can be decreased when combined with Venlafaxine.
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Venlafaxine.
AlbendazoleThe serum concentration of Venlafaxine can be increased when it is combined with Albendazole.
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Venlafaxine.
AldosteroneThe serum concentration of Venlafaxine can be decreased when it is combined with Aldosterone.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Venlafaxine.
AlectinibThe serum concentration of Venlafaxine can be increased when it is combined with Alectinib.
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Venlafaxine.
AlfentanilThe serum concentration of Venlafaxine can be increased when it is combined with Alfentanil.
AlfuzosinThe metabolism of Alfuzosin can be decreased when combined with Venlafaxine.
AliskirenThe metabolism of Aliskiren can be decreased when combined with Venlafaxine.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Venlafaxine.
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Venlafaxine.
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Venlafaxine.
AlmotriptanThe risk or severity of adverse effects can be increased when Almotriptan is combined with Venlafaxine.
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Venlafaxine.
AlosetronThe metabolism of Alosetron can be decreased when combined with Venlafaxine.
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Venlafaxine.
AlprenololThe metabolism of Alprenolol can be decreased when combined with Venlafaxine.
AmantadineThe serum concentration of Venlafaxine can be increased when it is combined with Amantadine.
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Venlafaxine.
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Venlafaxine.
Aminohippuric acidThe serum concentration of Venlafaxine can be increased when it is combined with Aminohippuric acid.
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Venlafaxine.
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Venlafaxine.
AmiodaroneThe metabolism of Amiodarone can be decreased when combined with Venlafaxine.
AmiodaroneThe serum concentration of Venlafaxine can be decreased when it is combined with Amiodarone.
AmisulprideThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Amisulpride.
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Venlafaxine.
AmitriptylineThe serum concentration of Venlafaxine can be increased when it is combined with Amitriptyline.
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Venlafaxine.
AmlodipineThe serum concentration of Venlafaxine can be increased when it is combined with Amlodipine.
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Venlafaxine.
AmoxapineThe risk or severity of adverse effects can be increased when Amoxapine is combined with Venlafaxine.
AmperozideThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Amperozide.
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Venlafaxine.
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Venlafaxine.
AmprenavirThe serum concentration of Venlafaxine can be decreased when it is combined with Amprenavir.
AmsacrineThe serum concentration of Venlafaxine can be increased when it is combined with Amsacrine.
AmsacrineThe metabolism of Amsacrine can be decreased when combined with Venlafaxine.
AnagrelideVenlafaxine may increase the QTc-prolonging activities of Anagrelide.
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Venlafaxine.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Venlafaxine.
ApomorphineVenlafaxine may decrease the antihypertensive activities of Apomorphine.
ApremilastThe metabolism of Apremilast can be decreased when combined with Venlafaxine.
AprepitantThe serum concentration of Venlafaxine can be increased when it is combined with Aprepitant.
AprepitantThe metabolism of Aprepitant can be decreased when combined with Venlafaxine.
AprindineThe metabolism of Aprindine can be decreased when combined with Venlafaxine.
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Venlafaxine.
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Venlafaxine.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Venlafaxine.
ArmodafinilThe metabolism of Venlafaxine can be decreased when combined with Armodafinil.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Venlafaxine.
ArtemetherThe metabolism of Artemether can be decreased when combined with Venlafaxine.
AsenapineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Asenapine.
AstemizoleThe metabolism of Astemizole can be decreased when combined with Venlafaxine.
AstemizoleThe serum concentration of Venlafaxine can be increased when it is combined with Astemizole.
AtazanavirThe metabolism of Atazanavir can be decreased when combined with Venlafaxine.
AtazanavirThe serum concentration of Venlafaxine can be increased when it is combined with Atazanavir.
AtenololThe serum concentration of Venlafaxine can be increased when it is combined with Atenolol.
AtomoxetineThe metabolism of Venlafaxine can be decreased when combined with Atomoxetine.
AtorvastatinThe metabolism of Atorvastatin can be decreased when combined with Venlafaxine.
AtorvastatinThe serum concentration of Venlafaxine can be increased when it is combined with Atorvastatin.
AvanafilThe metabolism of Avanafil can be decreased when combined with Venlafaxine.
AxitinibThe metabolism of Axitinib can be decreased when combined with Venlafaxine.
AzaperoneThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Azaperone.
AzelastineThe metabolism of Azelastine can be decreased when combined with Venlafaxine.
AzelastineThe serum concentration of Venlafaxine can be increased when it is combined with Azelastine.
AzithromycinVenlafaxine may increase the QTc-prolonging activities of Azithromycin.
AzithromycinThe serum concentration of Venlafaxine can be increased when it is combined with Azithromycin.
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Venlafaxine.
BedaquilineVenlafaxine may increase the QTc-prolonging activities of Bedaquiline.
BenmoxinBenmoxin may increase the serotonergic activities of Venlafaxine.
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Venlafaxine.
BenzocaineThe serum concentration of Venlafaxine can be increased when it is combined with Benzocaine.
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Venlafaxine.
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Venlafaxine.
BepridilThe serum concentration of Venlafaxine can be increased when it is combined with Bepridil.
BepridilThe metabolism of Bepridil can be decreased when combined with Venlafaxine.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Venlafaxine.
BetaxololThe metabolism of Betaxolol can be decreased when combined with Venlafaxine.
BethanidineVenlafaxine may decrease the antihypertensive activities of Bethanidine.
BexaroteneThe serum concentration of Venlafaxine can be decreased when it is combined with Bexarotene.
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Venlafaxine.
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Venlafaxine.
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Venlafaxine.
BifeprunoxThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Bifeprunox.
BiperidenThe serum concentration of Venlafaxine can be increased when it is combined with Biperiden.
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Venlafaxine.
BoceprevirThe metabolism of Boceprevir can be decreased when combined with Venlafaxine.
BortezomibThe metabolism of Venlafaxine can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Venlafaxine can be decreased when it is combined with Bosentan.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Venlafaxine.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Venlafaxine.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Venlafaxine.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Venlafaxine.
BrimonidineVenlafaxine may decrease the antihypertensive activities of Brimonidine.
BrinzolamideThe metabolism of Brinzolamide can be decreased when combined with Venlafaxine.
BromazepamThe metabolism of Bromazepam can be decreased when combined with Venlafaxine.
BromocriptineThe metabolism of Bromocriptine can be decreased when combined with Venlafaxine.
BromocriptineThe serum concentration of Venlafaxine can be increased when it is combined with Bromocriptine.
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Venlafaxine.
BudesonideThe metabolism of Budesonide can be decreased when combined with Venlafaxine.
BufuralolThe metabolism of Bufuralol can be decreased when combined with Venlafaxine.
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Venlafaxine.
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Venlafaxine.
BuprenorphineThe serum concentration of Venlafaxine can be increased when it is combined with Buprenorphine.
BupropionThe serum concentration of Bupropion can be increased when it is combined with Venlafaxine.
BupropionThe metabolism of Venlafaxine can be decreased when combined with Bupropion.
BuspironeThe metabolism of Buspirone can be decreased when combined with Venlafaxine.
BuspironeThe serum concentration of Venlafaxine can be increased when it is combined with Buspirone.
BusulfanThe metabolism of Busulfan can be decreased when combined with Venlafaxine.
CabazitaxelThe metabolism of Cabazitaxel can be decreased when combined with Venlafaxine.
CabazitaxelThe serum concentration of Venlafaxine can be increased when it is combined with Cabazitaxel.
CabergolineThe metabolism of Cabergoline can be decreased when combined with Venlafaxine.
CabergolineThe risk or severity of adverse effects can be increased when Cabergoline is combined with Venlafaxine.
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Venlafaxine.
CaffeineThe metabolism of Caffeine can be decreased when combined with Venlafaxine.
CaffeineThe serum concentration of Venlafaxine can be increased when it is combined with Caffeine.
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Venlafaxine.
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Venlafaxine.
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Venlafaxine.
CanagliflozinThe serum concentration of Venlafaxine can be increased when it is combined with Canagliflozin.
CandesartanThe serum concentration of Venlafaxine can be increased when it is combined with Candesartan.
CapecitabineThe metabolism of Venlafaxine can be decreased when combined with Capecitabine.
CaptoprilThe serum concentration of Venlafaxine can be increased when it is combined with Captopril.
CaptoprilThe metabolism of Captopril can be decreased when combined with Venlafaxine.
CarbamazepineThe metabolism of Carbamazepine can be decreased when combined with Venlafaxine.
CarbamazepineThe serum concentration of Venlafaxine can be decreased when it is combined with Carbamazepine.
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Venlafaxine.
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Venlafaxine.
CariprazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Cariprazine.
CaroxazoneCaroxazone may increase the serotonergic activities of Venlafaxine.
CarteololThe metabolism of Carteolol can be decreased when combined with Venlafaxine.
CarvedilolThe metabolism of Carvedilol can be decreased when combined with Venlafaxine.
CarvedilolThe serum concentration of Venlafaxine can be increased when it is combined with Carvedilol.
CaspofunginThe serum concentration of Venlafaxine can be increased when it is combined with Caspofungin.
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Venlafaxine.
CeliprololThe metabolism of Celiprolol can be decreased when combined with Venlafaxine.
CephalexinThe metabolism of Cephalexin can be decreased when combined with Venlafaxine.
CeritinibThe serum concentration of Venlafaxine can be increased when it is combined with Ceritinib.
CeritinibVenlafaxine may increase the QTc-prolonging activities of Ceritinib.
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Venlafaxine.
CevimelineThe metabolism of Cevimeline can be decreased when combined with Venlafaxine.
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Venlafaxine.
ChloramphenicolThe metabolism of Venlafaxine can be decreased when combined with Chloramphenicol.
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Venlafaxine.
ChloroquineVenlafaxine may increase the QTc-prolonging activities of Chloroquine.
ChloroquineThe serum concentration of Venlafaxine can be increased when it is combined with Chloroquine.
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Venlafaxine.
ChlorpromazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Chlorpromazine.
ChlorpromazineThe serum concentration of Venlafaxine can be increased when it is combined with Chlorpromazine.
ChlorpropamideThe serum concentration of Venlafaxine can be increased when it is combined with Chlorpropamide.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Chlorprothixene.
ChlorprothixeneThe serum concentration of Venlafaxine can be increased when it is combined with Chlorprothixene.
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Venlafaxine.
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Venlafaxine.
CholesterolThe serum concentration of Venlafaxine can be increased when it is combined with Cholesterol.
Cholic AcidThe serum concentration of Venlafaxine can be decreased when it is combined with Cholic Acid.
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Venlafaxine.
CilazaprilThe serum concentration of Venlafaxine can be increased when it is combined with Cilazapril.
CilostazolThe metabolism of Cilostazol can be decreased when combined with Venlafaxine.
CimetidineThe serum concentration of Venlafaxine can be decreased when it is combined with Cimetidine.
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Venlafaxine.
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Venlafaxine.
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Venlafaxine.
CiprofloxacinVenlafaxine may increase the QTc-prolonging activities of Ciprofloxacin.
CiprofloxacinThe serum concentration of Venlafaxine can be increased when it is combined with Ciprofloxacin.
CisaprideThe metabolism of Cisapride can be decreased when combined with Venlafaxine.
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Venlafaxine.
CitalopramThe metabolism of Citalopram can be decreased when combined with Venlafaxine.
CitalopramThe serum concentration of Venlafaxine can be increased when it is combined with Citalopram.
ClarithromycinVenlafaxine may increase the QTc-prolonging activities of Clarithromycin.
ClarithromycinThe serum concentration of Venlafaxine can be increased when it is combined with Clarithromycin.
ClemastineThe metabolism of Venlafaxine can be decreased when combined with Clemastine.
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Venlafaxine.
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Venlafaxine.
ClobazamThe metabolism of Clobazam can be decreased when combined with Venlafaxine.
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Venlafaxine.
ClofazimineThe serum concentration of Venlafaxine can be increased when it is combined with Clofazimine.
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Venlafaxine.
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Venlafaxine.
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Venlafaxine.
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Venlafaxine.
ClomipramineThe serum concentration of Venlafaxine can be increased when it is combined with Clomipramine.
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Venlafaxine.
ClonidineThe metabolism of Clonidine can be decreased when combined with Venlafaxine.
ClopidogrelThe metabolism of Clopidogrel can be decreased when combined with Venlafaxine.
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Venlafaxine.
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Venlafaxine.
ClotrimazoleThe metabolism of Venlafaxine can be decreased when combined with Clotrimazole.
ClozapineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Clozapine.
ClozapineThe metabolism of Venlafaxine can be decreased when combined with Clozapine.
CobicistatThe serum concentration of Venlafaxine can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Venlafaxine.
CocaineThe metabolism of Cocaine can be decreased when combined with Venlafaxine.
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Venlafaxine.
ColchicineThe metabolism of Colchicine can be decreased when combined with Venlafaxine.
ColchicineThe serum concentration of Venlafaxine can be increased when it is combined with Colchicine.
ColforsinThe serum concentration of Venlafaxine can be increased when it is combined with Colforsin.
ConivaptanThe serum concentration of Venlafaxine can be increased when it is combined with Conivaptan.
ConivaptanThe metabolism of Conivaptan can be decreased when combined with Venlafaxine.
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be decreased when combined with Venlafaxine.
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Venlafaxine.
CrizotinibVenlafaxine may increase the QTc-prolonging activities of Crizotinib.
CrizotinibThe metabolism of Venlafaxine can be decreased when combined with Crizotinib.
CyamemazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Cyamemazine.
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Venlafaxine.
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Venlafaxine.
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Venlafaxine.
CyclophosphamideThe serum concentration of Venlafaxine can be increased when it is combined with Cyclophosphamide.
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Venlafaxine.
CytarabineThe metabolism of Cytarabine can be decreased when combined with Venlafaxine.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Venlafaxine.
DabrafenibThe serum concentration of Venlafaxine can be decreased when it is combined with Dabrafenib.
DabrafenibThe metabolism of Dabrafenib can be decreased when combined with Venlafaxine.
DaclatasvirThe metabolism of Daclatasvir can be decreased when combined with Venlafaxine.
DaclatasvirThe serum concentration of Venlafaxine can be increased when it is combined with Daclatasvir.
DactinomycinThe serum concentration of Venlafaxine can be increased when it is combined with Dactinomycin.
DantroleneThe metabolism of Dantrolene can be decreased when combined with Venlafaxine.
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Venlafaxine.
DapiprazoleThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Dapiprazole.
DapoxetineThe risk or severity of adverse effects can be increased when Dapoxetine is combined with Venlafaxine.
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Venlafaxine.
DapsoneThe metabolism of Dapsone can be decreased when combined with Venlafaxine.
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Venlafaxine.
DarunavirThe serum concentration of Venlafaxine can be increased when it is combined with Darunavir.
DarunavirThe metabolism of Darunavir can be decreased when combined with Venlafaxine.
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Venlafaxine.
DasatinibThe serum concentration of Venlafaxine can be increased when it is combined with Dasatinib.
DasatinibThe metabolism of Dasatinib can be decreased when combined with Venlafaxine.
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Venlafaxine.
DaunorubicinThe serum concentration of Venlafaxine can be decreased when it is combined with Daunorubicin.
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Venlafaxine.
DeferasiroxThe serum concentration of Venlafaxine can be decreased when it is combined with Deferasirox.
DehydroepiandrosteroneThe metabolism of Dehydroepiandrosterone can be decreased when combined with Venlafaxine.
DelavirdineThe metabolism of Delavirdine can be decreased when combined with Venlafaxine.
DesipramineThe serum concentration of Venlafaxine can be increased when it is combined with Desipramine.
DesipramineThe metabolism of Desipramine can be decreased when combined with Venlafaxine.
DesloratadineThe serum concentration of Venlafaxine can be increased when it is combined with Desloratadine.
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Venlafaxine.
DesvenlafaxineThe risk or severity of adverse effects can be increased when Desvenlafaxine is combined with Venlafaxine.
DexamethasoneThe serum concentration of Venlafaxine can be decreased when it is combined with Dexamethasone.
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Venlafaxine.
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Venlafaxine.
DexmedetomidineVenlafaxine may decrease the antihypertensive activities of Dexmedetomidine.
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Venlafaxine.
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Venlafaxine.
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Venlafaxine.
DextromethorphanThe serum concentration of Venlafaxine can be increased when it is combined with Dextromethorphan.
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Venlafaxine.
DiazepamThe metabolism of Diazepam can be decreased when combined with Venlafaxine.
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Venlafaxine.
DiclofenacThe serum concentration of Venlafaxine can be increased when it is combined with Diclofenac.
DicoumarolThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Dicoumarol.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Venlafaxine.
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Venlafaxine.
DigoxinThe metabolism of Digoxin can be decreased when combined with Venlafaxine.
DigoxinThe serum concentration of Venlafaxine can be decreased when it is combined with Digoxin.
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Venlafaxine.
DihydroergotamineThe metabolism of Venlafaxine can be decreased when combined with Dihydroergotamine.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Venlafaxine.
DiltiazemThe metabolism of Venlafaxine can be decreased when combined with Diltiazem.
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Venlafaxine.
DipivefrinVenlafaxine may decrease the antihypertensive activities of Dipivefrin.
DipyridamoleThe serum concentration of Venlafaxine can be increased when it is combined with Dipyridamole.
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Venlafaxine.
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Venlafaxine.
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Venlafaxine.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Venlafaxine.
DolasetronVenlafaxine may increase the QTc-prolonging activities of Dolasetron.
DolasetronDolasetron may increase the serotonergic activities of Venlafaxine.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Venlafaxine.
DonepezilThe metabolism of Donepezil can be decreased when combined with Venlafaxine.
DopamineThe metabolism of Dopamine can be decreased when combined with Venlafaxine.
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Venlafaxine.
DoxazosinThe serum concentration of Venlafaxine can be increased when it is combined with Doxazosin.
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Venlafaxine.
DoxepinThe metabolism of Doxepin can be decreased when combined with Venlafaxine.
DoxepinThe serum concentration of Venlafaxine can be increased when it is combined with Doxepin.
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Venlafaxine.
DoxorubicinThe serum concentration of Venlafaxine can be decreased when it is combined with Doxorubicin.
DoxycyclineThe metabolism of Venlafaxine can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Venlafaxine.
DronedaroneThe metabolism of Dronedarone can be decreased when combined with Venlafaxine.
DroperidolThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Droperidol.
DroxidopaVenlafaxine may decrease the antihypertensive activities of Droxidopa.
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Venlafaxine.
DutasterideThe metabolism of Dutasteride can be decreased when combined with Venlafaxine.
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Venlafaxine.
EfavirenzThe serum concentration of Venlafaxine can be decreased when it is combined with Efavirenz.
EfavirenzThe metabolism of Efavirenz can be decreased when combined with Venlafaxine.
ElbasvirThe serum concentration of Venlafaxine can be increased when it is combined with Elbasvir.
EletriptanThe metabolism of Eletriptan can be decreased when combined with Venlafaxine.
EletriptanThe risk or severity of adverse effects can be increased when Eletriptan is combined with Venlafaxine.
EliglustatThe metabolism of Eliglustat can be decreased when combined with Venlafaxine.
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Venlafaxine.
EnalaprilThe metabolism of Enalapril can be decreased when combined with Venlafaxine.
EnalaprilThe serum concentration of Venlafaxine can be increased when it is combined with Enalapril.
EncainideThe metabolism of Encainide can be decreased when combined with Venlafaxine.
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Venlafaxine.
EnzalutamideThe metabolism of Enzalutamide can be decreased when combined with Venlafaxine.
EnzalutamideThe serum concentration of Venlafaxine can be increased when it is combined with Enzalutamide.
EphedraVenlafaxine may decrease the antihypertensive activities of Ephedra.
EpinastineThe metabolism of Epinastine can be decreased when combined with Venlafaxine.
EpinephrineVenlafaxine may decrease the antihypertensive activities of Epinephrine.
EplerenoneThe metabolism of Eplerenone can be decreased when combined with Venlafaxine.
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Venlafaxine.
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Venlafaxine.
Ergoloid mesylateThe risk or severity of adverse effects can be increased when Ergoloid mesylate is combined with Venlafaxine.
ErgonovineThe metabolism of Ergonovine can be decreased when combined with Venlafaxine.
ErgonovineThe serum concentration of Venlafaxine can be increased when it is combined with Ergonovine.
ErgotamineThe metabolism of Ergotamine can be decreased when combined with Venlafaxine.
ErgotamineThe serum concentration of Venlafaxine can be increased when it is combined with Ergotamine.
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Venlafaxine.
ErythromycinVenlafaxine may increase the QTc-prolonging activities of Erythromycin.
ErythromycinThe metabolism of Venlafaxine can be decreased when combined with Erythromycin.
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Venlafaxine.
EscitalopramThe risk or severity of adverse effects can be increased when Escitalopram is combined with Venlafaxine.
Eslicarbazepine acetateThe serum concentration of Venlafaxine can be decreased when it is combined with Eslicarbazepine acetate.
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Venlafaxine.
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Venlafaxine.
EstazolamThe metabolism of Estazolam can be decreased when combined with Venlafaxine.
EstradiolThe metabolism of Estradiol can be decreased when combined with Venlafaxine.
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Venlafaxine.
EstramustineThe metabolism of Estramustine can be decreased when combined with Venlafaxine.
EstramustineThe serum concentration of Venlafaxine can be increased when it is combined with Estramustine.
EstriolThe serum concentration of Venlafaxine can be decreased when it is combined with Estriol.
EstriolThe serum concentration of Estriol can be increased when it is combined with Venlafaxine.
EstroneThe metabolism of Estrone can be decreased when combined with Venlafaxine.
EstroneThe serum concentration of Venlafaxine can be decreased when it is combined with Estrone.
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Venlafaxine.
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Venlafaxine.
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Venlafaxine.
EthanolThe metabolism of Ethanol can be decreased when combined with Venlafaxine.
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Venlafaxine.
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Venlafaxine.
Ethyl biscoumacetateThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Ethyl biscoumacetate.
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Venlafaxine.
EtomidateVenlafaxine may decrease the antihypertensive activities of Etomidate.
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Venlafaxine.
EtoposideThe metabolism of Etoposide can be decreased when combined with Venlafaxine.
EtoposideThe serum concentration of Venlafaxine can be increased when it is combined with Etoposide.
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Venlafaxine.
EtravirineThe serum concentration of Venlafaxine can be decreased when it is combined with Etravirine.
EtravirineThe metabolism of Etravirine can be decreased when combined with Venlafaxine.
EverolimusThe metabolism of Everolimus can be decreased when combined with Venlafaxine.
ExemestaneThe metabolism of Exemestane can be decreased when combined with Venlafaxine.
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Venlafaxine.
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Venlafaxine.
FelbamateThe metabolism of Felbamate can be decreased when combined with Venlafaxine.
FelodipineThe metabolism of Felodipine can be decreased when combined with Venlafaxine.
FelodipineThe serum concentration of Venlafaxine can be increased when it is combined with Felodipine.
FencamfamineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Fencamfamine.
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Venlafaxine.
FentanylThe metabolism of Fentanyl can be decreased when combined with Venlafaxine.
FentanylThe serum concentration of Venlafaxine can be increased when it is combined with Fentanyl.
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Venlafaxine.
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Venlafaxine.
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Venlafaxine.
FinasterideThe metabolism of Finasteride can be decreased when combined with Venlafaxine.
FingolimodThe metabolism of Fingolimod can be decreased when combined with Venlafaxine.
FlecainideVenlafaxine may increase the QTc-prolonging activities of Flecainide.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Venlafaxine.
FloxuridineThe metabolism of Venlafaxine can be decreased when combined with Floxuridine.
FluconazoleThe metabolism of Venlafaxine can be decreased when combined with Fluconazole.
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Venlafaxine.
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Venlafaxine.
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Venlafaxine.
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Venlafaxine.
FluorouracilThe metabolism of Venlafaxine can be decreased when combined with Fluorouracil.
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Venlafaxine.
FluoxetineThe serum concentration of Venlafaxine can be increased when it is combined with Fluoxetine.
FlupentixolThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Flupentixol.
FlupentixolThe serum concentration of Venlafaxine can be increased when it is combined with Flupentixol.
FluphenazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Fluphenazine.
FluphenazineThe serum concentration of Venlafaxine can be increased when it is combined with Fluphenazine.
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Venlafaxine.
FlurazepamThe serum concentration of Venlafaxine can be increased when it is combined with Flurazepam.
FluspirileneThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Fluspirilene.
FlutamideThe metabolism of Flutamide can be decreased when combined with Venlafaxine.
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Venlafaxine.
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be decreased when combined with Venlafaxine.
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Venlafaxine.
FluvoxamineThe metabolism of Venlafaxine can be decreased when combined with Fluvoxamine.
FormoterolThe metabolism of Formoterol can be decreased when combined with Venlafaxine.
FosamprenavirThe metabolism of Fosamprenavir can be decreased when combined with Venlafaxine.
FosaprepitantThe serum concentration of Venlafaxine can be increased when it is combined with Fosaprepitant.
FosphenytoinThe metabolism of Venlafaxine can be increased when combined with Fosphenytoin.
FrovatriptanThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Frovatriptan.
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Venlafaxine.
FurazolidoneFurazolidone may increase the serotonergic activities of Venlafaxine.
Fusidic AcidThe serum concentration of Venlafaxine can be increased when it is combined with Fusidic Acid.
Gadobenic acidVenlafaxine may increase the QTc-prolonging activities of Gadobenic acid.
GalantamineThe metabolism of Galantamine can be decreased when combined with Venlafaxine.
GefitinibThe metabolism of Gefitinib can be decreased when combined with Venlafaxine.
GefitinibThe serum concentration of Venlafaxine can be increased when it is combined with Gefitinib.
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Venlafaxine.
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Venlafaxine.
GemifloxacinVenlafaxine may increase the QTc-prolonging activities of Gemifloxacin.
GenisteinThe serum concentration of Venlafaxine can be increased when it is combined with Genistein.
GlipizideThe metabolism of Glipizide can be decreased when combined with Venlafaxine.
GlyburideThe metabolism of Glyburide can be decreased when combined with Venlafaxine.
GlyburideThe serum concentration of Venlafaxine can be increased when it is combined with Glyburide.
GlycerolThe serum concentration of Venlafaxine can be increased when it is combined with Glycerol.
GoserelinVenlafaxine may increase the QTc-prolonging activities of Goserelin.
Gramicidin DThe serum concentration of Venlafaxine can be increased when it is combined with Gramicidin D.
GranisetronVenlafaxine may increase the QTc-prolonging activities of Granisetron.
GranisetronGranisetron may increase the serotonergic activities of Venlafaxine.
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Venlafaxine.
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Venlafaxine.
GrepafloxacinThe serum concentration of Venlafaxine can be increased when it is combined with Grepafloxacin.
GuanabenzVenlafaxine may decrease the antihypertensive activities of Guanabenz.
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Venlafaxine.
HalofantrineThe metabolism of Halofantrine can be decreased when combined with Venlafaxine.
HaloperidolThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Haloperidol.
HaloperidolThe serum concentration of Venlafaxine can be increased when it is combined with Haloperidol.
HalothaneThe metabolism of Halothane can be decreased when combined with Venlafaxine.
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Venlafaxine.
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Venlafaxine.
HydracarbazineHydracarbazine may increase the serotonergic activities of Venlafaxine.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Venlafaxine.
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Venlafaxine.
HydrocortisoneThe serum concentration of Venlafaxine can be increased when it is combined with Hydrocortisone.
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Venlafaxine.
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Venlafaxine.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Venlafaxine.
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Venlafaxine.
IbutilideVenlafaxine may increase the QTc-prolonging activities of Ibutilide.
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Venlafaxine.
IdelalisibThe serum concentration of Venlafaxine can be increased when it is combined with Idelalisib.
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Venlafaxine resulting in a loss in efficacy.
IloperidoneThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Iloperidone.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Venlafaxine.
ImatinibThe metabolism of Venlafaxine can be decreased when combined with Imatinib.
ImipramineThe metabolism of Imipramine can be decreased when combined with Venlafaxine.
ImipramineThe serum concentration of Venlafaxine can be increased when it is combined with Imipramine.
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Venlafaxine.
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Venlafaxine.
IndapamideThe metabolism of Indapamide can be decreased when combined with Venlafaxine.
IndinavirThe serum concentration of Indinavir can be decreased when it is combined with Venlafaxine.
IndomethacinThe serum concentration of Venlafaxine can be increased when it is combined with Indomethacin.
Ioflupane I 123Venlafaxine may decrease effectiveness of Ioflupane I 123 as a diagnostic agent.
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Venlafaxine.
IproclozideIproclozide may increase the serotonergic activities of Venlafaxine.
IproniazidIproniazid may increase the serotonergic activities of Venlafaxine.
IrbesartanThe metabolism of Venlafaxine can be decreased when combined with Irbesartan.
IrinotecanThe metabolism of Irinotecan can be decreased when combined with Venlafaxine.
IsavuconazoniumThe metabolism of Isavuconazonium can be decreased when combined with Venlafaxine.
IsocarboxazidThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Isocarboxazid.
IsocarboxazidIsocarboxazid may increase the serotonergic activities of Venlafaxine.
IsofluraneThe metabolism of Isoflurane can be decreased when combined with Venlafaxine.
IsoniazidThe metabolism of Venlafaxine can be decreased when combined with Isoniazid.
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Venlafaxine.
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Venlafaxine.
IsradipineThe metabolism of Venlafaxine can be decreased when combined with Isradipine.
ItraconazoleThe metabolism of Itraconazole can be decreased when combined with Venlafaxine.
ItraconazoleThe serum concentration of Venlafaxine can be increased when it is combined with Itraconazole.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Venlafaxine.
IvacaftorThe serum concentration of Venlafaxine can be increased when it is combined with Ivacaftor.
IvacaftorThe metabolism of Ivacaftor can be decreased when combined with Venlafaxine.
IvermectinThe metabolism of Ivermectin can be decreased when combined with Venlafaxine.
IvermectinThe serum concentration of Venlafaxine can be increased when it is combined with Ivermectin.
IxabepiloneThe metabolism of Ixabepilone can be decreased when combined with Venlafaxine.
IxazomibThe metabolism of Ixazomib can be decreased when combined with Venlafaxine.
KetamineThe metabolism of Ketamine can be decreased when combined with Venlafaxine.
KetamineThe serum concentration of Venlafaxine can be increased when it is combined with Ketamine.
KetazolamThe metabolism of Ketazolam can be decreased when combined with Venlafaxine.
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Venlafaxine.
KetoconazoleThe metabolism of Ketoconazole can be decreased when combined with Venlafaxine.
KetoconazoleThe serum concentration of Venlafaxine can be increased when it is combined with Ketoconazole.
LabetalolThe metabolism of Labetalol can be decreased when combined with Venlafaxine.
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Venlafaxine.
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Venlafaxine.
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Venlafaxine.
LansoprazoleThe serum concentration of Venlafaxine can be increased when it is combined with Lansoprazole.
LapatinibThe metabolism of Lapatinib can be decreased when combined with Venlafaxine.
LapatinibThe serum concentration of Venlafaxine can be increased when it is combined with Lapatinib.
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Venlafaxine.
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Venlafaxine.
LeflunomideThe metabolism of Venlafaxine can be decreased when combined with Leflunomide.
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Venlafaxine.
LenvatinibVenlafaxine may increase the QTc-prolonging activities of Lenvatinib.
LercanidipineThe metabolism of Lercanidipine can be decreased when combined with Venlafaxine.
LetrozoleThe metabolism of Letrozole can be decreased when combined with Venlafaxine.
LeuprolideVenlafaxine may increase the QTc-prolonging activities of Leuprolide.
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Venlafaxine.
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Venlafaxine.
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Venlafaxine.
LevodopaThe metabolism of Levodopa can be decreased when combined with Venlafaxine.
LevofloxacinVenlafaxine may increase the QTc-prolonging activities of Levofloxacin.
LevofloxacinThe serum concentration of Venlafaxine can be increased when it is combined with Levofloxacin.
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Venlafaxine.
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Venlafaxine.
LevomilnacipranThe risk or severity of adverse effects can be increased when Levomilnacipran is combined with Venlafaxine.
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Venlafaxine.
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Venlafaxine.
LevothyroxineThe serum concentration of Venlafaxine can be decreased when it is combined with Levothyroxine.
LidocaineThe metabolism of Lidocaine can be decreased when combined with Venlafaxine.
LidocaineThe serum concentration of Venlafaxine can be increased when it is combined with Lidocaine.
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Venlafaxine.
LinezolidLinezolid may increase the serotonergic activities of Venlafaxine.
LinezolidThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Linezolid.
LiothyronineThe serum concentration of Venlafaxine can be decreased when it is combined with Liothyronine.
LiotrixThe serum concentration of Venlafaxine can be decreased when it is combined with Liotrix.
LisinoprilThe serum concentration of Venlafaxine can be increased when it is combined with Lisinopril.
LisurideThe metabolism of Lisuride can be decreased when combined with Venlafaxine.
LithiumThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Lithium.
LofexidineVenlafaxine may decrease the antihypertensive activities of Lofexidine.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Venlafaxine.
LomustineThe metabolism of Lomustine can be decreased when combined with Venlafaxine.
LoperamideThe metabolism of Loperamide can be decreased when combined with Venlafaxine.
LoperamideThe serum concentration of Venlafaxine can be increased when it is combined with Loperamide.
LopinavirThe metabolism of Lopinavir can be decreased when combined with Venlafaxine.
LopinavirThe serum concentration of Venlafaxine can be increased when it is combined with Lopinavir.
LoratadineThe metabolism of Loratadine can be decreased when combined with Venlafaxine.
LoratadineThe serum concentration of Venlafaxine can be increased when it is combined with Loratadine.
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Venlafaxine.
LosartanThe metabolism of Losartan can be decreased when combined with Venlafaxine.
LosartanThe serum concentration of Venlafaxine can be increased when it is combined with Losartan.
LovastatinThe metabolism of Venlafaxine can be decreased when combined with Lovastatin.
LoxapineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Loxapine.
LuliconazoleThe serum concentration of Venlafaxine can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Venlafaxine can be decreased when it is combined with Lumacaftor.
LumefantrineThe metabolism of Lumefantrine can be decreased when combined with Venlafaxine.
LurasidoneThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Lurasidone.
MacitentanThe metabolism of Macitentan can be decreased when combined with Venlafaxine.
MalathionThe metabolism of Malathion can be decreased when combined with Venlafaxine.
MannitolThe serum concentration of Mannitol can be increased when it is combined with Venlafaxine.
MaprotilineThe serum concentration of Venlafaxine can be increased when it is combined with Maprotiline.
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Venlafaxine.
MaravirocThe metabolism of Maraviroc can be decreased when combined with Venlafaxine.
MebanazineMebanazine may increase the serotonergic activities of Venlafaxine.
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Venlafaxine.
MebendazoleThe serum concentration of Venlafaxine can be increased when it is combined with Mebendazole.
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be decreased when combined with Venlafaxine.
MefloquineThe metabolism of Mefloquine can be decreased when combined with Venlafaxine.
MefloquineThe serum concentration of Venlafaxine can be increased when it is combined with Mefloquine.
Megestrol acetateThe serum concentration of Venlafaxine can be increased when it is combined with Megestrol acetate.
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Venlafaxine.
MelperoneThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Melperone.
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Venlafaxine.
MeprobamateThe serum concentration of Venlafaxine can be increased when it is combined with Meprobamate.
MequitazineThe metabolism of Mequitazine can be decreased when combined with Venlafaxine.
MesoridazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Mesoridazine.
MethadoneVenlafaxine may increase the QTc-prolonging activities of Methadone.
MethadoneThe serum concentration of Venlafaxine can be increased when it is combined with Methadone.
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Venlafaxine.
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Venlafaxine.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Venlafaxine.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Methotrimeprazine.
MethotrimeprazineThe metabolism of Venlafaxine can be decreased when combined with Methotrimeprazine.
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Venlafaxine.
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Venlafaxine.
Methylene blueVenlafaxine may increase the serotonergic activities of Methylene blue.
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Venlafaxine.
MethylphenobarbitalThe metabolism of Methylphenobarbital can be decreased when combined with Venlafaxine.
MethylprednisoloneThe metabolism of Methylprednisolone can be decreased when combined with Venlafaxine.
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Venlafaxine.
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Venlafaxine.
MetoclopramideThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Metoclopramide.
MetoprololThe serum concentration of Venlafaxine can be increased when it is combined with Metoprolol.
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Venlafaxine.
MexiletineThe metabolism of Mexiletine can be decreased when combined with Venlafaxine.
MianserinThe metabolism of Mianserin can be decreased when combined with Venlafaxine.
MibefradilThe metabolism of Mibefradil can be decreased when combined with Venlafaxine.
MibefradilThe serum concentration of Venlafaxine can be increased when it is combined with Mibefradil.
MiconazoleThe metabolism of Miconazole can be decreased when combined with Venlafaxine.
MiconazoleThe serum concentration of Venlafaxine can be increased when it is combined with Miconazole.
MidazolamThe metabolism of Midazolam can be decreased when combined with Venlafaxine.
MidazolamThe serum concentration of Venlafaxine can be decreased when it is combined with Midazolam.
MifepristoneThe metabolism of Mifepristone can be decreased when combined with Venlafaxine.
MilnacipranThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Milnacipran.
MinaprineThe metabolism of Minaprine can be decreased when combined with Venlafaxine.
MinaprineMinaprine may increase the serotonergic activities of Venlafaxine.
MirabegronThe metabolism of Mirabegron can be decreased when combined with Venlafaxine.
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Venlafaxine.
MirtazapineThe risk or severity of adverse effects can be increased when Mirtazapine is combined with Venlafaxine.
MitomycinThe serum concentration of Venlafaxine can be increased when it is combined with Mitomycin.
MitotaneThe serum concentration of Venlafaxine can be decreased when it is combined with Mitotane.
MitoxantroneThe serum concentration of Venlafaxine can be decreased when it is combined with Mitoxantrone.
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Venlafaxine.
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Venlafaxine.
MoclobemideMoclobemide may increase the serotonergic activities of Venlafaxine.
ModafinilThe serum concentration of Venlafaxine can be decreased when it is combined with Modafinil.
ModafinilThe metabolism of Modafinil can be decreased when combined with Venlafaxine.
MolindoneThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Molindone.
MontelukastThe metabolism of Montelukast can be decreased when combined with Venlafaxine.
MorphineThe metabolism of Morphine can be decreased when combined with Venlafaxine.
MorphineThe serum concentration of Venlafaxine can be increased when it is combined with Morphine.
MoxifloxacinVenlafaxine may increase the QTc-prolonging activities of Moxifloxacin.
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Venlafaxine.
NadololThe serum concentration of Nadolol can be increased when it is combined with Venlafaxine.
NafcillinThe serum concentration of Venlafaxine can be decreased when it is combined with Nafcillin.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Venlafaxine.
NaloxoneThe metabolism of Naloxone can be decreased when combined with Venlafaxine.
NaltrexoneThe serum concentration of Venlafaxine can be increased when it is combined with Naltrexone.
NaphazolineVenlafaxine may decrease the antihypertensive activities of Naphazoline.
NaratriptanThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Naratriptan.
NaringeninThe serum concentration of Venlafaxine can be increased when it is combined with Naringenin.
NateglinideThe metabolism of Nateglinide can be decreased when combined with Venlafaxine.
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Venlafaxine.
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Venlafaxine.
NefazodoneThe serum concentration of Venlafaxine can be decreased when it is combined with Nefazodone.
NelfinavirThe metabolism of Nelfinavir can be decreased when combined with Venlafaxine.
NelfinavirThe serum concentration of Venlafaxine can be decreased when it is combined with Nelfinavir.
NeostigmineThe serum concentration of Venlafaxine can be increased when it is combined with Neostigmine.
NetupitantThe serum concentration of Venlafaxine can be increased when it is combined with Netupitant.
NetupitantThe metabolism of Netupitant can be decreased when combined with Venlafaxine.
NevirapineThe metabolism of Venlafaxine can be decreased when combined with Nevirapine.
NialamideNialamide may increase the serotonergic activities of Venlafaxine.
NicardipineThe metabolism of Nicardipine can be decreased when combined with Venlafaxine.
NicardipineThe serum concentration of Venlafaxine can be increased when it is combined with Nicardipine.
NicergolineThe metabolism of Nicergoline can be decreased when combined with Venlafaxine.
NicotineThe metabolism of Nicotine can be decreased when combined with Venlafaxine.
NifedipineThe metabolism of Nifedipine can be decreased when combined with Venlafaxine.
NifedipineThe serum concentration of Venlafaxine can be decreased when it is combined with Nifedipine.
NilotinibThe metabolism of Nilotinib can be decreased when combined with Venlafaxine.
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Venlafaxine.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Venlafaxine.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Venlafaxine.
NisoldipineThe metabolism of Nisoldipine can be decreased when combined with Venlafaxine.
NisoldipineThe serum concentration of Venlafaxine can be increased when it is combined with Nisoldipine.
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Venlafaxine.
NitrazepamThe serum concentration of Venlafaxine can be increased when it is combined with Nitrazepam.
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Venlafaxine.
NitrendipineThe serum concentration of Venlafaxine can be increased when it is combined with Nitrendipine.
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Venlafaxine.
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Venlafaxine.
NorepinephrineVenlafaxine may decrease the antihypertensive activities of Norepinephrine.
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Venlafaxine.
NorethisteroneThe serum concentration of Venlafaxine can be decreased when it is combined with Norethisterone.
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Venlafaxine.
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Venlafaxine.
NortriptylineThe risk or severity of adverse effects can be increased when Nortriptyline is combined with Venlafaxine.
OctamoxinOctamoxin may increase the serotonergic activities of Venlafaxine.
OfloxacinVenlafaxine may increase the QTc-prolonging activities of Ofloxacin.
OlanzapineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Olanzapine.
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Venlafaxine.
OlaparibThe metabolism of Venlafaxine can be decreased when combined with Olaparib.
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Venlafaxine.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Venlafaxine.
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Venlafaxine.
OmeprazoleThe serum concentration of Venlafaxine can be increased when it is combined with Omeprazole.
OndansetronThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Ondansetron.
OndansetronOndansetron may increase the serotonergic activities of Venlafaxine.
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Venlafaxine.
OsanetantThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Osanetant.
OsimertinibThe serum concentration of Venlafaxine can be increased when it is combined with Osimertinib.
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Venlafaxine.
OxazepamThe metabolism of Oxazepam can be decreased when combined with Venlafaxine.
OxybutyninThe metabolism of Oxybutynin can be decreased when combined with Venlafaxine.
OxycodoneThe metabolism of Oxycodone can be decreased when combined with Venlafaxine.
OxymetazolineVenlafaxine may decrease the antihypertensive activities of Oxymetazoline.
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Venlafaxine.
P-NitrophenolThe serum concentration of Venlafaxine can be increased when it is combined with P-Nitrophenol.
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Venlafaxine.
PaclitaxelThe serum concentration of Venlafaxine can be increased when it is combined with Paclitaxel.
PalbociclibThe serum concentration of Venlafaxine can be increased when it is combined with Palbociclib.
PalbociclibThe metabolism of Palbociclib can be decreased when combined with Venlafaxine.
PaliperidoneThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Paliperidone.
Palmitic AcidThe serum concentration of Venlafaxine can be increased when it is combined with Palmitic Acid.
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Venlafaxine.
PalonosetronPalonosetron may increase the serotonergic activities of Venlafaxine.
PanobinostatVenlafaxine may increase the QTc-prolonging activities of Panobinostat.
PanobinostatThe metabolism of Venlafaxine can be decreased when combined with Panobinostat.
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Venlafaxine.
PantoprazoleThe serum concentration of Venlafaxine can be increased when it is combined with Pantoprazole.
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Venlafaxine.
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Venlafaxine.
ParecoxibThe metabolism of Parecoxib can be decreased when combined with Venlafaxine.
PargylinePargyline may increase the serotonergic activities of Venlafaxine.
ParicalcitolThe metabolism of Paricalcitol can be decreased when combined with Venlafaxine.
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Venlafaxine.
ParoxetineThe serum concentration of Venlafaxine can be increased when it is combined with Paroxetine.
ParoxetineThe metabolism of Paroxetine can be decreased when combined with Venlafaxine.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Venlafaxine.
Peginterferon alfa-2bThe serum concentration of Venlafaxine can be decreased when it is combined with Peginterferon alfa-2b.
PentamidineVenlafaxine may increase the QTc-prolonging activities of Pentamidine.
PentobarbitalThe metabolism of Venlafaxine can be increased when combined with Pentobarbital.
PerampanelThe metabolism of Perampanel can be decreased when combined with Venlafaxine.
PerflutrenVenlafaxine may increase the QTc-prolonging activities of Perflutren.
PergolideThe metabolism of Pergolide can be decreased when combined with Venlafaxine.
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Venlafaxine.
PerindoprilThe serum concentration of Venlafaxine can be increased when it is combined with Perindopril.
PermethrinThe metabolism of Permethrin can be decreased when combined with Venlafaxine.
PerospironeThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Perospirone.
PerphenazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Perphenazine.
PethidineThe metabolism of Pethidine can be decreased when combined with Venlafaxine.
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Venlafaxine.
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Venlafaxine.
PhenelzineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Phenelzine.
PhenelzinePhenelzine may increase the serotonergic activities of Venlafaxine.
PhenforminThe metabolism of Phenformin can be decreased when combined with Venlafaxine.
PhenindioneThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Phenindione.
PheniprazinePheniprazine may increase the serotonergic activities of Venlafaxine.
PhenobarbitalThe serum concentration of Venlafaxine can be decreased when it is combined with Phenobarbital.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Venlafaxine.
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Venlafaxine.
PhenoxypropazinePhenoxypropazine may increase the serotonergic activities of Venlafaxine.
PhenprocoumonThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Phenprocoumon.
PhenylpropanolamineVenlafaxine may decrease the antihypertensive activities of Phenylpropanolamine.
PhenytoinThe metabolism of Venlafaxine can be increased when combined with Phenytoin.
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Venlafaxine.
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Venlafaxine.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Venlafaxine.
PinacidilThe metabolism of Pinacidil can be decreased when combined with Venlafaxine.
PindololThe metabolism of Pindolol can be decreased when combined with Venlafaxine.
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Venlafaxine.
PipamperoneThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Pipamperone.
PiperazineThe metabolism of Piperazine can be decreased when combined with Venlafaxine.
PipotiazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Pipotiazine.
PirlindolePirlindole may increase the serotonergic activities of Venlafaxine.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Venlafaxine.
PivhydrazinePivhydrazine may increase the serotonergic activities of Venlafaxine.
Platelet Activating FactorThe serum concentration of Venlafaxine can be decreased when it is combined with Platelet Activating Factor.
PodofiloxThe metabolism of Podofilox can be decreased when combined with Venlafaxine.
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Venlafaxine.
PonatinibThe metabolism of Ponatinib can be decreased when combined with Venlafaxine.
PonatinibThe serum concentration of Venlafaxine can be increased when it is combined with Ponatinib.
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Venlafaxine.
PosaconazoleThe serum concentration of Venlafaxine can be increased when it is combined with Posaconazole.
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Venlafaxine.
PravastatinThe metabolism of Pravastatin can be decreased when combined with Venlafaxine.
PravastatinThe serum concentration of Venlafaxine can be increased when it is combined with Pravastatin.
PrazepamThe metabolism of Prazepam can be decreased when combined with Venlafaxine.
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Venlafaxine.
PrazosinThe serum concentration of Venlafaxine can be increased when it is combined with Prazosin.
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Venlafaxine.
PrednisoneThe metabolism of Prednisone can be decreased when combined with Venlafaxine.
PrednisoneThe serum concentration of Venlafaxine can be increased when it is combined with Prednisone.
PrimaquineVenlafaxine may increase the QTc-prolonging activities of Primaquine.
PrimidoneThe metabolism of Venlafaxine can be increased when combined with Primidone.
ProbenecidThe serum concentration of Venlafaxine can be increased when it is combined with Probenecid.
ProcainamideThe metabolism of Procainamide can be decreased when combined with Venlafaxine.
ProcarbazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Procarbazine.
ProchlorperazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Prochlorperazine.
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Venlafaxine.
ProgesteroneThe serum concentration of Venlafaxine can be decreased when it is combined with Progesterone.
ProguanilThe metabolism of Proguanil can be decreased when combined with Venlafaxine.
PromazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Promazine.
PromazineThe metabolism of Venlafaxine can be decreased when combined with Promazine.
PromethazineThe serum concentration of Venlafaxine can be increased when it is combined with Promethazine.
PromethazineThe metabolism of Promethazine can be decreased when combined with Venlafaxine.
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Venlafaxine.
PropericiazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Propericiazine.
PropofolThe metabolism of Propofol can be decreased when combined with Venlafaxine.
PropranololThe metabolism of Propranolol can be decreased when combined with Venlafaxine.
PropranololThe serum concentration of Venlafaxine can be increased when it is combined with Propranolol.
ProtriptylineThe serum concentration of Venlafaxine can be increased when it is combined with Protriptyline.
ProtriptylineThe metabolism of Protriptyline can be decreased when combined with Venlafaxine.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Venlafaxine.
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Venlafaxine.
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Venlafaxine.
PyrimethamineThe metabolism of Venlafaxine can be decreased when combined with Pyrimethamine.
QuazepamThe metabolism of Quazepam can be decreased when combined with Venlafaxine.
QuercetinThe serum concentration of Venlafaxine can be increased when it is combined with Quercetin.
QuetiapineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Quetiapine.
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Venlafaxine.
QuinacrineThe serum concentration of Venlafaxine can be increased when it is combined with Quinacrine.
QuinidineThe metabolism of Quinidine can be decreased when combined with Venlafaxine.
QuinidineThe serum concentration of Venlafaxine can be increased when it is combined with Quinidine.
QuinineThe metabolism of Quinine can be decreased when combined with Venlafaxine.
QuinineThe serum concentration of Venlafaxine can be increased when it is combined with Quinine.
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Venlafaxine.
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Venlafaxine.
RamelteonThe metabolism of Ramelteon can be decreased when combined with Venlafaxine.
RanitidineThe serum concentration of Venlafaxine can be increased when it is combined with Ranitidine.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Venlafaxine.
RasagilineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Rasagiline.
RasagilineRasagiline may increase the serotonergic activities of Venlafaxine.
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Venlafaxine.
ReboxetineThe serum concentration of Venlafaxine can be increased when it is combined with Reboxetine.
RegorafenibThe metabolism of Regorafenib can be decreased when combined with Venlafaxine.
RegorafenibThe serum concentration of Venlafaxine can be increased when it is combined with Regorafenib.
RemoxiprideThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Remoxipride.
RepaglinideThe metabolism of Repaglinide can be decreased when combined with Venlafaxine.
repinotanThe metabolism of repinotan can be decreased when combined with Venlafaxine.
ReserpineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Reserpine.
ReserpineThe serum concentration of Venlafaxine can be decreased when it is combined with Reserpine.
RetapamulinThe metabolism of Retapamulin can be decreased when combined with Venlafaxine.
RifabutinThe metabolism of Venlafaxine can be increased when combined with Rifabutin.
RifampicinThe metabolism of Rifampicin can be decreased when combined with Venlafaxine.
RifampicinThe serum concentration of Venlafaxine can be decreased when it is combined with Rifampicin.
RifapentineThe metabolism of Venlafaxine can be increased when combined with Rifapentine.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Venlafaxine.
RilpivirineThe metabolism of Rilpivirine can be decreased when combined with Venlafaxine.
RilpivirineThe serum concentration of Venlafaxine can be increased when it is combined with Rilpivirine.
RimonabantThe metabolism of Rimonabant can be decreased when combined with Venlafaxine.
RiociguatThe metabolism of Riociguat can be decreased when combined with Venlafaxine.
RisperidoneThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Risperidone.
RitonavirThe metabolism of Ritonavir can be decreased when combined with Venlafaxine.
RitonavirThe serum concentration of Venlafaxine can be decreased when it is combined with Ritonavir.
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Venlafaxine.
RizatriptanThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Rizatriptan.
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Venlafaxine.
RolapitantThe metabolism of Rolapitant can be decreased when combined with Venlafaxine.
RolapitantThe serum concentration of Venlafaxine can be increased when it is combined with Rolapitant.
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Venlafaxine.
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Venlafaxine.
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Venlafaxine.
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Venlafaxine.
RotigotineThe metabolism of Rotigotine can be decreased when combined with Venlafaxine.
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Venlafaxine.
RuxolitinibThe metabolism of Ruxolitinib can be decreased when combined with Venlafaxine.
SafrazineSafrazine may increase the serotonergic activities of Venlafaxine.
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Venlafaxine.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Venlafaxine.
SaquinavirVenlafaxine may increase the QTc-prolonging activities of Saquinavir.
SaquinavirThe serum concentration of Venlafaxine can be decreased when it is combined with Saquinavir.
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Venlafaxine.
ScopolamineThe serum concentration of Venlafaxine can be increased when it is combined with Scopolamine.
SecobarbitalThe metabolism of Venlafaxine can be increased when combined with Secobarbital.
SelegilineThe metabolism of Selegiline can be decreased when combined with Venlafaxine.
SelegilineSelegiline may increase the serotonergic activities of Venlafaxine.
SelexipagThe metabolism of Selexipag can be decreased when combined with Venlafaxine.
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Venlafaxine.
SertindoleThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Sertindole.
SertralineThe metabolism of Sertraline can be decreased when combined with Venlafaxine.
SertralineThe serum concentration of Venlafaxine can be increased when it is combined with Sertraline.
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Venlafaxine.
SibutramineThe metabolism of Sibutramine can be decreased when combined with Venlafaxine.
SildenafilThe metabolism of Venlafaxine can be decreased when combined with Sildenafil.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Venlafaxine.
SiltuximabThe serum concentration of Venlafaxine can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Venlafaxine can be increased when it is combined with Simeprevir.
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Venlafaxine.
SimvastatinThe serum concentration of Venlafaxine can be increased when it is combined with Simvastatin.
SirolimusThe metabolism of Sirolimus can be decreased when combined with Venlafaxine.
SirolimusThe serum concentration of Venlafaxine can be decreased when it is combined with Sirolimus.
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Venlafaxine.
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Venlafaxine.
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Venlafaxine.
SonidegibThe metabolism of Sonidegib can be decreased when combined with Venlafaxine.
SorafenibThe metabolism of Sorafenib can be decreased when combined with Venlafaxine.
SorafenibThe serum concentration of Venlafaxine can be increased when it is combined with Sorafenib.
SotalolVenlafaxine may increase the QTc-prolonging activities of Sotalol.
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Venlafaxine.
SparteineThe metabolism of Sparteine can be decreased when combined with Venlafaxine.
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Venlafaxine.
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Venlafaxine.
SpironolactoneThe serum concentration of Venlafaxine can be increased when it is combined with Spironolactone.
St. John's WortThe serum concentration of Venlafaxine can be decreased when it is combined with St. John's Wort.
StaurosporineThe serum concentration of Venlafaxine can be increased when it is combined with Staurosporine.
StiripentolThe serum concentration of Venlafaxine can be increased when it is combined with Stiripentol.
StreptozocinThe serum concentration of Venlafaxine can be decreased when it is combined with Streptozocin.
SufentanilThe metabolism of Sufentanil can be decreased when combined with Venlafaxine.
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Venlafaxine.
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Venlafaxine.
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Venlafaxine.
SulfinpyrazoneThe serum concentration of Venlafaxine can be increased when it is combined with Sulfinpyrazone.
SulfisoxazoleVenlafaxine may increase the QTc-prolonging activities of Sulfisoxazole.
SulfisoxazoleThe metabolism of Venlafaxine can be decreased when combined with Sulfisoxazole.
SulpirideThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Sulpiride.
SumatriptanThe serum concentration of Venlafaxine can be increased when it is combined with Sumatriptan.
SumatriptanThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Sumatriptan.
SunitinibThe metabolism of Sunitinib can be decreased when combined with Venlafaxine.
SunitinibThe serum concentration of Venlafaxine can be increased when it is combined with Sunitinib.
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Venlafaxine.
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Venlafaxine.
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Venlafaxine.
TacrineThe serum concentration of Venlafaxine can be increased when it is combined with Tacrine.
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Venlafaxine.
TacrolimusThe serum concentration of Venlafaxine can be decreased when it is combined with Tacrolimus.
TadalafilThe metabolism of Tadalafil can be decreased when combined with Venlafaxine.
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Venlafaxine.
TamoxifenThe serum concentration of Venlafaxine can be decreased when it is combined with Tamoxifen.
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Venlafaxine.
TapentadolThe metabolism of Tapentadol can be decreased when combined with Venlafaxine.
TapentadolThe risk or severity of adverse effects can be increased when Tapentadol is combined with Venlafaxine.
TasosartanThe metabolism of Tasosartan can be decreased when combined with Venlafaxine.
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Venlafaxine.
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Venlafaxine.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Venlafaxine.
Tedizolid PhosphateTedizolid Phosphate may increase the serotonergic activities of Venlafaxine.
Tedizolid PhosphateThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Tedizolid Phosphate.
TegaserodThe metabolism of Tegaserod can be decreased when combined with Venlafaxine.
TelaprevirThe metabolism of Telaprevir can be decreased when combined with Venlafaxine.
TelavancinVenlafaxine may increase the QTc-prolonging activities of Telavancin.
TelithromycinVenlafaxine may increase the QTc-prolonging activities of Telithromycin.
TelithromycinThe metabolism of Venlafaxine can be decreased when combined with Telithromycin.
TelmisartanThe serum concentration of Venlafaxine can be increased when it is combined with Telmisartan.
TemazepamThe metabolism of Temazepam can be decreased when combined with Venlafaxine.
TemsirolimusThe metabolism of Temsirolimus can be decreased when combined with Venlafaxine.
TemsirolimusThe serum concentration of Venlafaxine can be increased when it is combined with Temsirolimus.
TeniposideThe metabolism of Teniposide can be decreased when combined with Venlafaxine.
TerazosinThe serum concentration of Venlafaxine can be increased when it is combined with Terazosin.
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Venlafaxine.
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Venlafaxine.
TerfenadineThe serum concentration of Venlafaxine can be increased when it is combined with Terfenadine.
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Venlafaxine.
TesmilifeneThe serum concentration of Venlafaxine can be decreased when it is combined with Tesmilifene.
TestosteroneThe metabolism of Testosterone can be decreased when combined with Venlafaxine.
TestosteroneThe serum concentration of Venlafaxine can be increased when it is combined with Testosterone.
TetrabenazineThe metabolism of Tetrabenazine can be decreased when combined with Venlafaxine.
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Venlafaxine.
TheophyllineThe metabolism of Theophylline can be decreased when combined with Venlafaxine.
ThioproperazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Thioproperazine.
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Venlafaxine.
ThioridazineThe metabolism of Venlafaxine can be decreased when combined with Thioridazine.
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Venlafaxine.
ThiothixeneThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Thiothixene.
TiagabineThe metabolism of Tiagabine can be decreased when combined with Venlafaxine.
TicagrelorThe metabolism of Ticagrelor can be decreased when combined with Venlafaxine.
TicagrelorThe serum concentration of Venlafaxine can be increased when it is combined with Ticagrelor.
TiclopidineThe metabolism of Venlafaxine can be decreased when combined with Ticlopidine.
TimololThe serum concentration of Timolol can be increased when it is combined with Venlafaxine.
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Venlafaxine.
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Venlafaxine.
TipranavirThe metabolism of Tipranavir can be decreased when combined with Venlafaxine.
TizanidineVenlafaxine may decrease the antihypertensive activities of Tizanidine.
TocilizumabThe serum concentration of Venlafaxine can be decreased when it is combined with Tocilizumab.
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Venlafaxine.
TolbutamideThe metabolism of Venlafaxine can be decreased when combined with Tolbutamide.
ToloxatoneToloxatone may increase the serotonergic activities of Venlafaxine.
TolterodineThe metabolism of Tolterodine can be decreased when combined with Venlafaxine.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Venlafaxine.
TopiramateThe metabolism of Venlafaxine can be decreased when combined with Topiramate.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Venlafaxine.
ToremifeneThe metabolism of Toremifene can be decreased when combined with Venlafaxine.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Venlafaxine.
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Venlafaxine.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Venlafaxine.
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the serotonergic activities of Venlafaxine.
TranylcypromineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Tranylcypromine.
TranylcypromineTranylcypromine may increase the serotonergic activities of Venlafaxine.
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be decreased when combined with Venlafaxine.
TrazodoneThe metabolism of Trazodone can be decreased when combined with Venlafaxine.
TrazodoneThe serum concentration of Venlafaxine can be decreased when it is combined with Trazodone.
TretinoinThe metabolism of Tretinoin can be decreased when combined with Venlafaxine.
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Venlafaxine.
TriazolamThe metabolism of Triazolam can be decreased when combined with Venlafaxine.
TrifluoperazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Trifluoperazine.
TrifluoperazineThe serum concentration of Venlafaxine can be increased when it is combined with Trifluoperazine.
TriflupromazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Triflupromazine.
TriflupromazineThe serum concentration of Venlafaxine can be increased when it is combined with Triflupromazine.
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Venlafaxine.
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Venlafaxine.
TrimethoprimThe serum concentration of Venlafaxine can be decreased when it is combined with Trimethoprim.
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Venlafaxine.
TrimipramineThe serum concentration of Venlafaxine can be increased when it is combined with Trimipramine.
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Venlafaxine.
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Venlafaxine.
TroleandomycinThe serum concentration of Venlafaxine can be increased when it is combined with Troleandomycin.
UdenafilThe metabolism of Udenafil can be decreased when combined with Venlafaxine.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Venlafaxine.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Venlafaxine.
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Venlafaxine.
Valproic AcidThe metabolism of Venlafaxine can be decreased when combined with Valproic Acid.
ValsartanThe metabolism of Venlafaxine can be decreased when combined with Valsartan.
VandetanibThe metabolism of Vandetanib can be decreased when combined with Venlafaxine.
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Venlafaxine.
VardenafilThe metabolism of Vardenafil can be decreased when combined with Venlafaxine.
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Venlafaxine.
VemurafenibThe metabolism of Vemurafenib can be decreased when combined with Venlafaxine.
VerapamilThe metabolism of Verapamil can be decreased when combined with Venlafaxine.
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Venlafaxine.
VilanterolThe metabolism of Vilanterol can be decreased when combined with Venlafaxine.
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Venlafaxine.
VilazodoneThe risk or severity of adverse effects can be increased when Vilazodone is combined with Venlafaxine.
VinblastineThe metabolism of Vinblastine can be decreased when combined with Venlafaxine.
VinblastineThe serum concentration of Venlafaxine can be decreased when it is combined with Vinblastine.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Venlafaxine.
VincristineThe serum concentration of Venlafaxine can be decreased when it is combined with Vincristine.
VindesineThe serum concentration of Vindesine can be increased when it is combined with Venlafaxine.
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Venlafaxine.
VinorelbineThe serum concentration of Venlafaxine can be increased when it is combined with Vinorelbine.
VismodegibThe metabolism of Vismodegib can be decreased when combined with Venlafaxine.
VoriconazoleThe risk or severity of adverse effects can be increased when Voriconazole is combined with Venlafaxine.
VoriconazoleThe metabolism of Voriconazole can be decreased when combined with Venlafaxine.
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Venlafaxine.
VortioxetineThe risk or severity of adverse effects can be increased when Vortioxetine is combined with Venlafaxine.
WarfarinThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Warfarin.
XylometazolineVenlafaxine may decrease the antihypertensive activities of Xylometazoline.
YohimbineThe metabolism of Yohimbine can be decreased when combined with Venlafaxine.
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Venlafaxine.
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Venlafaxine.
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Venlafaxine.
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Venlafaxine.
ZileutonThe metabolism of Zileuton can be decreased when combined with Venlafaxine.
ZimelidineThe serum concentration of Venlafaxine can be increased when it is combined with Zimelidine.
ZiprasidoneThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Ziprasidone.
ZiprasidoneThe metabolism of Venlafaxine can be decreased when combined with Ziprasidone.
ZolmitriptanThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Zolmitriptan.
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Venlafaxine.
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Venlafaxine.
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Venlafaxine.
ZopicloneThe metabolism of Zopiclone can be decreased when combined with Venlafaxine.
ZotepineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Zotepine.
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Venlafaxine.
Food Interactions
  • Avoid alcohol.
  • Avoid St.John's Wort.
  • Take with food.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Serotonin:sodium symporter activity
Specific Function:
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin an...
Gene Name:
SLC6A4
Uniprot ID:
P31645
Molecular Weight:
70324.165 Da
References
  1. Chen F, Larsen MB, Sanchez C, Wiborg O: The S-enantiomer of R,S-citalopram, increases inhibitor binding to the human serotonin transporter by an allosteric mechanism. Comparison with other serotonin transporter inhibitors. Eur Neuropsychopharmacol. 2005 Mar;15(2):193-8. [PubMed:15695064 ]
  2. Gould GG, Altamirano AV, Javors MA, Frazer A: A comparison of the chronic treatment effects of venlafaxine and other antidepressants on serotonin and norepinephrine transporters. Biol Psychiatry. 2006 Mar 1;59(5):408-14. Epub 2005 Sep 2. [PubMed:16140280 ]
  3. Shang Y, Gibbs MA, Marek GJ, Stiger T, Burstein AH, Marek K, Seibyl JP, Rogers JF: Displacement of serotonin and dopamine transporters by venlafaxine extended release capsule at steady state: a [123I]2beta-carbomethoxy-3beta-(4-iodophenyl)-tropane single photon emission computed tomography imaging study. J Clin Psychopharmacol. 2007 Feb;27(1):71-5. [PubMed:17224717 ]
  4. Malizia AL, Melichar JM, Brown DJ, Gunn RN, Reynolds A, Jones T, Nutt DJ: Demonstration of clomipramine and venlafaxine occupation at serotonin reuptake sites in man in vivo. J Psychopharmacol. 1997;11(3):279-81. [PubMed:9305421 ]
  5. Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. [PubMed:9537821 ]
  6. Van Ameringen M, Mancini C, Patterson B, Simpson W: Pharmacotherapy for social anxiety disorder: an update. Isr J Psychiatry Relat Sci. 2009;46(1):53-61. [PubMed:19728573 ]
  7. Beique J, de Montigny C, Blier P, Debonnel G: Effects of sustained administration of the serotonin and norepinephrine reuptake inhibitor venlafaxine: I. in vivo electrophysiological studies in the rat. Neuropharmacology. 2000 Jul 24;39(10):1800-12. [PubMed:10884561 ]
  8. Westenberg HG: Recent advances in understanding and treating social anxiety disorder. CNS Spectr. 2009 Feb;14(2 Suppl 3):24-33. [PubMed:19238127 ]
  9. Sindrup SH, Otto M, Finnerup NB, Jensen TS: Antidepressants in the treatment of neuropathic pain. Basic Clin Pharmacol Toxicol. 2005 Jun;96(6):399-409. [PubMed:15910402 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Norepinephrine:sodium symporter activity
Specific Function:
Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name:
SLC6A2
Uniprot ID:
P23975
Molecular Weight:
69331.42 Da
References
  1. Vaishnavi SN, Nemeroff CB, Plott SJ, Rao SG, Kranzler J, Owens MJ: Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity. Biol Psychiatry. 2004 Feb 1;55(3):320-2. [PubMed:14744476 ]
  2. Mitchell HA, Ahern TH, Liles LC, Javors MA, Weinshenker D: The effects of norepinephrine transporter inactivation on locomotor activity in mice. Biol Psychiatry. 2006 Nov 15;60(10):1046-52. Epub 2006 Aug 7. [PubMed:16893531 ]
  3. Beique JC, Lavoie N, de Montigny C, Debonnel G: Affinities of venlafaxine and various reuptake inhibitors for the serotonin and norepinephrine transporters. Eur J Pharmacol. 1998 May 15;349(1):129-32. [PubMed:9669506 ]
  4. Van Ameringen M, Mancini C, Patterson B, Simpson W: Pharmacotherapy for social anxiety disorder: an update. Isr J Psychiatry Relat Sci. 2009;46(1):53-61. [PubMed:19728573 ]
  5. Beique J, de Montigny C, Blier P, Debonnel G: Effects of sustained administration of the serotonin and norepinephrine reuptake inhibitor venlafaxine: I. in vivo electrophysiological studies in the rat. Neuropharmacology. 2000 Jul 24;39(10):1800-12. [PubMed:10884561 ]
  6. Westenberg HG: Recent advances in understanding and treating social anxiety disorder. CNS Spectr. 2009 Feb;14(2 Suppl 3):24-33. [PubMed:19238127 ]
  7. Sindrup SH, Otto M, Finnerup NB, Jensen TS: Antidepressants in the treatment of neuropathic pain. Basic Clin Pharmacol Toxicol. 2005 Jun;96(6):399-409. [PubMed:15910402 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Monoamine transmembrane transporter activity
Specific Function:
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name:
SLC6A3
Uniprot ID:
Q01959
Molecular Weight:
68494.255 Da
References
  1. Dawson LA, Nguyen HQ, Geiger A: Effects of venlafaxine on extracellular concentrations of 5-HT and noradrenaline in the rat frontal cortex: augmentation via 5-HT1A receptor antagonism. Neuropharmacology. 1999 Aug;38(8):1153-63. [PubMed:10462128 ]
  2. Bourin M: [Psychopharmacological profile of venlafaxine]. Encephale. 1999 Jun;25 Spec No 2:21-2; discussion 23-5. [PubMed:10434156 ]
  3. Barkin RL, Fawcett J: The management challenges of chronic pain: the role of antidepressants. Am J Ther. 2000 Jan;7(1):31-47. [PubMed:11319571 ]
  4. Lemke MR: [Antidepressant effects of dopamine agonists. Experimental and clinical findings]. Nervenarzt. 2007 Jan;78(1):31-8. [PubMed:17187269 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Fogelman SM, Schmider J, Venkatakrishnan K, von Moltke LL, Harmatz JS, Shader RI, Greenblatt DJ: O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: effect of metabolic inhibitors and SSRI antidepressants. Neuropsychopharmacology. 1999 May;20(5):480-90. [PubMed:10192828 ]
  4. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Weiss J, Dormann SM, Martin-Facklam M, Kerpen CJ, Ketabi-Kiyanvash N, Haefeli WE: Inhibition of P-glycoprotein by newer antidepressants. J Pharmacol Exp Ther. 2003 Apr;305(1):197-204. [PubMed:12649369 ]
  2. Uhr M, Grauer MT, Holsboer F: Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-glycoprotein gene disruption. Biol Psychiatry. 2003 Oct 15;54(8):840-6. [PubMed:14550684 ]
  3. Karlsson L, Schmitt U, Josefsson M, Carlsson B, Ahlner J, Bengtsson F, Kugelberg FC, Hiemke C: Blood-brain barrier penetration of the enantiomers of venlafaxine and its metabolites in mice lacking P-glycoprotein. Eur Neuropsychopharmacol. 2010 Sep;20(9):632-40. doi: 10.1016/j.euroneuro.2010.04.004. Epub 2010 May 13. [PubMed:20466523 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from t...
Gene Name:
ABCG2
Uniprot ID:
Q9UNQ0
Molecular Weight:
72313.47 Da
References
  1. Bachmeier CJ, Beaulieu-Abdelahad D, Ganey NJ, Mullan MJ, Levin GM: Induction of drug efflux protein expression by venlafaxine but not desvenlafaxine. Biopharm Drug Dispos. 2011 May;32(4):233-44. doi: 10.1002/bdd.753. Epub 2011 Mar 28. [PubMed:21446053 ]
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Drug created on June 13, 2005 07:24 / Updated on August 30, 2016 03:27