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Identification
NameDoxylamine
Accession NumberDB00366  (APRD00937)
TypeSmall Molecule
GroupsApproved, Vet Approved
DescriptionHistamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. [PubChem]
Structure
Thumb
Synonyms
2-(alpha-(2-(Dimethylamino)ethoxy)-alpha-methylbenzyl)pyridine
2-Dimethylaminoethoxyphenylmethyl-2-picoline
Dossilamina
Doxilamina
Doxilminio
Doxylaminum
N,N-Dimethyl-2-(1-phenyl-1-(2-pyridinyl)ethoxy)ethanamine
Phenyl-2-pyridylmethyl-beta-N,N-dimethylaminoethyl ether
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
7 Select Sleep Aidtablet25 mg/1oral7 Eleven2014-08-05Not applicableUs
Care One Sleep Aidtablet25 mg/1oralAmerican Sales Company2004-06-29Not applicableUs
Equaline Sleep Aidtablet25 mg/1oralSupervalu Inc2004-08-10Not applicableUs
Good Neighbor Pharmacy Sleep Aidtablet25 mg/1oralAmerisource Bergen1997-06-26Not applicableUs
Good Sense Sleep Aidtablet25 mg/1oralL. Perrigo Company1997-04-14Not applicableUs
Harris Teeter Sleep Aidtablet25 mg/1oralHarris Teeter, LLC2015-11-21Not applicableUs
Health Mart Sleep Aidtablet25 mg/1oralMc Kesson2011-11-21Not applicableUs
Healthy Accents Sleep Aidtablet25 mg/1oralDZA Brands LLC2011-06-06Not applicableUs
Kirkland Signature Sleep Aidtablet25 mg/1oralCostco Wholesale Company2003-06-27Not applicableUs
Leader Sleep Aidtablet25 mg/1oralCardinal Health1997-10-21Not applicableUs
Nighttime Fast Sleep Aidtablet25 mg/1oralFRED'S, INC.2002-04-112016-02-26Us
Nighttime Sleep Aidtablet25 mg/1oralCVS Pharmacy1997-07-23Not applicableUs
Nighttime Sleep Aidtablet25 mg/1oralBetter Living Brands, Llc2002-04-11Not applicableUs
Nighttime Sleep Aidtablet25 mg/1oralHy Vee Inc2014-12-04Not applicableUs
Nighttime Sleep Aidtablet25 mg/1oralWOONSOCKET PRESCRIPTION CENTER,INCORPORATED2002-04-11Not applicableUs
Nighttime Sleep Aidtablet25 mg/1oralGREAT LAKES WHOLESALE, MARKETING, & SALES, INC.2002-04-11Not applicableUs
Nighttime Sleep Aidtablet25 mg/1oralKroger Company2014-07-15Not applicableUs
Nighttime Sleep Aidtablet25 mg/1oralWal Mart Stores Inc2002-04-11Not applicableUs
Nighttime Sleepaidtablet25 mg/1oralWestern Family Foods Inc1997-11-11Not applicableUs
Sambrosa Sweet Dreams Nighttimesyrup9.75 mg/5mLoralSambrosa Care Inc.2015-07-01Not applicableUs
Sleep Aidtablet25 mg/1oralKroger Company1997-05-02Not applicableUs
Sleep Aidtablet25 mg/1oralCostco Wholesale Corporation2002-04-11Not applicableUs
Sleep Aidtablet25 mg/1oralMeijer Distribution Inc1997-02-21Not applicableUs
Sleep Aidtablet25 mg/1oralH E B1998-05-06Not applicableUs
Sleep Aidtablet25 mg/1oralHy Vee Inc1998-09-01Not applicableUs
Sleep Aidtablet25 mg/1oralHannaford Brothers Company1997-02-07Not applicableUs
Sleep Aidtablet25 mg/1oralSUPERVALU INC.2002-04-11Not applicableUs
Sleep Aidtablet25 mg/1oralCardinal Health2002-04-11Not applicableUs
Sleep Aidtablet25 mg/1oralRite Aid2001-04-11Not applicableUs
Sleep-aidtablet25 mg/1oralH E B2002-04-11Not applicableUs
Smart Sense Sleep Aidtablet25 mg/1oralKmart Corporation2010-12-29Not applicableUs
Sunmark Sleep Aidtablet25 mg/1oralMc Kesson2003-08-15Not applicableUs
Topcare Sleep Aidtablet25 mg/1oralTopco Associates LLC1997-01-29Not applicableUs
Unisom Sleeptabstablet25 mg/1oralChattem, Inc.1978-10-18Not applicableUs
Unisom Sleeptabstablet25 mg/1oralChattem, Inc.2016-01-15Not applicableUs
Unisom-2 Tabletstablet25 mgoralPaladin Labs Inc1987-12-31Not applicableCanada
Wal Som Nighttime Sleep Aidtablet25 mg/1oralWalgreen Company1999-03-05Not applicableUs
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
7 Select Night Time Relief7 Eleven
Acetaminophen Dextromethorphan Hydrobromide and Doxylamine SuccinateJ.P. BUSINESS ENTERPRISE
Acetaminophen, Dextromethorphan Hydrobromide, and Doxylamine SuccinateSpirit Pharmaceuticals, Llc
Acetaminophen,dextromethorphan,doxylamineAgile Pharmachem
Acetaminophen/pseudoephedrine/dextromethorphan/doxylamineApotex Inc
Alka-seltzer Plus Day and Night Cold and Flu FormulaBayer Health Care Llc, Consumer Care
Alka-seltzer Plus Day and Night Multi-symptom Cold and Flu FormulaBayer Health Care Llc, Consumer Care
Alka-seltzer Plus Day and Night Severe Cold and FluBayer Health Care Consumer Care
Alka-seltzer Plus Night Cold and Flu FormulaBayer Health Care Llc, Consumer Care
Alka-seltzer Plus Night Cold Formula (lemon)Bayer Health Care Consumer Care
Alka-seltzer Plus Night Cold MedicineBayer Health Care Llc, Consumer Care
Alka-seltzer Plus Night Severe Cold and FluBayer Health Care Consumer Care
Alka-seltzer Plus Severe Allergy Sinus Congestion and Headache FormulaBayer Health Care Llc, Consumer Care
Alka-seltzer Plus Severe Sinus Congestion and Cough Day and NightBayer Health Care Llc, Consumer Care
Alka-seltzer Plus Severe Sinus Congestion, Allergy and CoughBayer Health Care Llc, Consumer Care
All NiteMajor Pharmaceuticals
All-nite Cold and FluMajor Pharmaceuticals
Allergy and CoughWestern Family Foods Inc
Aurophen Cold Multi SymptomAurohealth LLC
Auroquil Cold and Flu Nighttime ReliefAurohealth LLC
Auroquil Cough Nighttime Cough ReliefAurohealth LLC
Auroquil Severe Cold and Flu Nighttime ReliefAurohealth LLC
Being Well Cold and Flu Relief PMSave A Lot Food Stores Ltd
Being Well Cold Flu Relief PM Multi SymptomSave A Lot Food Stores Ltd
Being Well Night Time Cold and FluSave A Lot Food Stores Ltd
Buckley's Cold & Sinus NightThe Buckley's Company
Buckley's Complete Nighttime SoftgelsThe Buckley's Company
Buckleys Nighttime Cold and SinusThe Buckley's Company
Care One Cold Mutli SymptomAmerican Sales Company
Careone Cold and CoughAmerican Sales Company
Careone Cold MaxAmerican Sales Company
Careone Daytime Nighttime Cold Flu ReliefAmerican Sales Company
Careone Night Time Cold and FluAmerican Sales Company
Careone Nighttime Cold and FluAmerican Sales Company
Careone Nighttime Severe Cold and FluAmerican Sales Company
Careone Nitetime Cold Flu ReliefAmerican Sales Company
Careone Nitetime CoughAmerican Sales Company
Careone Nitetime Severe Cold Flu ReliefAmerican Sales Company
Careone Severe Sinus CongestionAmerican Sales Company
Circle K Nighttime Cold and FluLil' Drug Store Products, Inc
CleartimeHy Vee Inc
Cold & FluVita Health Products Inc
Cold & Flu NighttimeArrow Otc Company
Cold & Flu Relief NighttimeVita Health Products Inc
Cold & Sinus Liquid CapsulesVita Health Products Inc
Cold and CoughH E B
Cold and Cough NighttimeCVS Pharmacy
Cold and Cough Nighttime Cool BlastQUALITY CHOICE (Chain Drug Marketing Association)
Cold and FluWalgreen Company
Cold and Flu Day NightHy Vee Inc
Cold and Flu Daytime NighttimeL&R Distributors, Inc.
Cold and Flu Daytime, Nighttime, Maximum StrengthWALGREEN CO.
Cold and Flu Daytime, Nighttime, Multi-symptomWALGREEN CO.
Cold and Flu Medicine - Night Time FormulaPharmetics (2011) Inc
Cold and Flu Multi-symptom Daytime NighttimeArmy and Air Force Exchange Service
Cold and Flu NighttimeL&R Distributors, Inc.
Cold and Flu Nighttime DWalgreen Company
Cold and Flu Nighttime Multi SymptomL&R Distributors, Inc.
Cold and Flu Nighttime ReliefFreds Inc
Cold and Flu Nighttime/multi-symptomWALGREEN CO.
Cold and Flu ReliefWalgreen Company
Cold and Flu Relief Daytime NighttimeRite Aid Corporation
Cold and Flu Relief Multi SymptomWin Co Foods, Llc
Cold and Flu Relief Multi Symptom NighttimeWin Co Foods, Llc
Cold and Flu Relief Multi-symptomArmy and Air Force Exchange Service
Cold and Flu Relief Multi-symptom, NighttimeArmy and Air Force Exchange Service
Cold and Flu Relief NighttimeAmerisource Bergen (Good Neighbor Pharmacy) 46122
Cold and Flu Relief Nighttime Multi SymptomP And L Development Of New York Corporation (Ready In Case)
Cold and Flu Relief Nighttime, Multi-symptomArmy and Air Force Exchange Service
Cold and Flu Relief Non-drowsy / Daytime Severe / Nighttime SevereWOONSOCKET PRESCRIPTION CENTER,INCORPORATED
Cold and Flu Severe, Nighttime, Maximum StrengthWALGREEN CO.
Cold and Sinus Nighttime ReliefVita Health Products Inc
Cold and Sinus Relief ComboVita Health Products Inc
Cold Flu ReliefPerrigo International
Cold Multi SymptomH E B
Cold Relief Multi Symptom NighttimeCVS Pharmacy
Cold/flu MedicinePerrigo International
Complete Liquid CapsulesVita Health Products Inc
Complete Liquid Capsules Nighttime ReliefVita Health Products Inc
Conrx NighttimeEagle Distributors,Inc.
Contac Cold and Flu Cooling ReliefMeda Consumer Healthcare Inc.
CoughWalgreen Company
Cough and Sore Throat Multi SymptomMeijer Distribution Inc
Cough and Sore Throat NighttimeKinray LLC
Cough and Sore Throat Pain ReliefHy Vee Inc
Cough Day NightHy Vee Inc
Cough Multi SymptomKinray LLC
Cough Nighttime Cough ReliefChain Drug Consortium, LLC
Cough Relief Daytime NighttimeWalgreen Company
Cough Relief NighttimeWalgreen Company
Cvs Nighttime Cold/flu ReliefCVS Pharmacy
DalmacolLaboratoire Riva Inc
Day Night Cold and FluHy Vee Inc
Day Relief Night Relief FreeWestern Family Foods Inc
Day Relief Night Relief Sinus PEWestern Family Foods Inc
Day Time and Night Time Sinus and CongestionWalgreens Company
Day Time Night TimeShopko Stores Operating Co., LLC
Day Time Night Time Cold and FluWalgreens Company
Day Time Night Time Sinus ReliefWalgeens Company
Day Time Nighttime CoughHy Vee Inc
Day-time Night-timeChain Drug Consortium, LLC
Daytime and Nighttime Cold and Flu ReliefChain Drug Consortium, LLC
Daytime and Nighttime Cold and Flu Relief PlusChain Drug Consortium, LLC
Daytime Cough Nighttime CoughCVS Pharmacy
Daytime NighttimeShopko Stores Operating Co., LLC
Daytime Nighttime CleartimeHy Vee Inc
Daytime Nighttime Cold and FluWalgreen Company
Daytime Nighttime Cold and Flu ReliefRite Aid Corporation
Daytime Nighttime Cold and Flu Relief Multi-symptomFamily Dollar (FAMILY WELLNESS)
Daytime Nighttime Cold Flu ReliefSafeway, Inc.
Daytime Nighttime Cold/fluAgile Pharmachem
Daytime Nighttime Multi Symptom Cold and Flu ReliefShopko Stores Operating Co., LLC.
Daytime Nighttime Multi Symptom Cold Flu ReliefCVS Pharmacy
Daytime Nighttime Severe Cold and FluWalgreen Company
Daytime Nighttime Severe Cold and Flu ReliefRite Aid Corporation
Daytime Nighttime Sinus ReliefHy Vee
Daytime Nite TimeKroger Company
Daytime NitetimeKroger Company
Daytime Nitetime Cold and FluKroger Company
Daytime Nitetime Cold and Flu ReliefCare One (American Sales Company)
Daytime Nitetime Cold Flu ReliefCare One (American Sales Company)
Daytime Nitetime SinusMeijer Distribution Inc
Daytime Nitetime Sinus ReliefTOP CARE (Topco Associates LLC)
Daytime PE NitetimePublix Super Markets Inc
Daytime/nighttime Cold and Flu Multi-symptom ReliefL&R Distributors, Inc.
Daytime/nitetime Severe Cold and Flu Maximum StrengthMeijer
Delsym Night Time Multi-symptomReckitt Benckiser LLC
Dg Health Cold and Flu ReliefDolgencorp Inc
Dg Health Cold and Flu Relief Night TimeDolgencorp, LLC
Dg Health Cold and Flu Relief Nite TimeDolgencorp, LLC
Dg Health Cough and Sore Throat Nite TimeDolgencorp, LLC
Dg Health Cough Night TimeDolgencorp, LLC
Dg Health Night Time Cold and Flu ReliefDolgencorp, LLC
Dg Health Pain Relief Cold Night TimeDolgencorp, LLC
DiclectinDuchesnay Inc
DiclegisDuchesnay Usa, Inc.
Equaline Daytime and Nighttime Cold and Flu ReliefSupervalu Inc
Equaline Daytime Nighttime Cold and Flu ReliefSupervalu Inc
Equaline Night Time CoughSupervalu Inc
Equaline NighttimeSupervalu Inc
Equaline Nighttime Cold and Flu ReliefSupervalu Inc
Equaline Nighttime Cough ReliefSupervalu Inc
Equaline Nighttime Severe Cold and FluSupervalu Inc
Equate Daytime NitetimeWal Mart Stores Inc
Equate Daytime Nitetime SevereWal Mart Stores Inc
Equate Nighttime Liquid CapsulesIvax Pharmaceuticals Incorporated
Equate Nite Time Cold Flu ReliefWal Mart Stores Inc
Equate Nite Time CoughWal Mart Stores Inc
Equate NitetimeWal Mart Stores Inc
Equate Nitetime Cold and FluWal Mart Stores Inc
Equate Nitetime DaytimeWal Mart Stores Inc
Equate Nitetime SevereWal Mart Stores Inc
Equate Sinus Night TimeWal Mart Stores Inc
Extra Strength Tylenol Cold and Flu NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Family Care Cold and Flu Multi SymptomUNITED EXCHANGE CORP.
Family Care Cold and Flu NighttimeUNITED EXCHANGE CORP.
Family Care Cough NighttimeUNITED EXCHANGE CORP.
Fulton Street Market Cold and FluAccess Business Group LLC
Fulton Street Market Night Time Cold and FluAccess Business Group LLC
GlentussGlendale Inc
Good Neighbor Pharmacy Cold Multi SymptomAmerisource Bergen
Good Neighbor Pharmacy Cough and Sore ThroatAmerisource Bergen
Good Neighbor Pharmacy Multi SymptomAmerisource Bergen
Good Neighbor Pharmacy Night TimeAmerisource Bergen
Good Neighbor Pharmacy Night Time Cold and FluAmerisource Bergen
Good Neighbor Pharmacy Night Time CoughAmerisource Bergen
Good Neighbor Pharmacy Night Time DAmerisource Bergen
Good Neighbor Pharmacy Night Time SevereAmerisource Bergen
Good Neighbor Pharmacy Severe Night TimeAmerisource Bergen
Good Neighbor Pharmacy Severe Sinus CongestionAmerisource Bergen
Good Sense Cough and Sore Throat Night TimeL Perrigo Company
Good Sense Daytime Night TimeL Perrigo Company
Good Sense Night TimeL Perrigo Company
Good Sense Night Time Cold and FluL. Perrigo Company
Good Sense NighttimeL. Perrigo Company
Good Sense Nighttime CoughL. Perrigo Company
Good Sense Nighttime Daytime Cold and FluL. Perrigo Company
Good Sense Severe NighttimeL Perrigo Company
Good Sense Severe Nighttime Cold and FluL. Perrigo Company
Good Sense Severe Sinus CongestionL. Perrigo Company
Harmon Face Values Night Time ReliefHarmon Stores Inc.
Harris Teeter Daytime NighttimeHarris Teeter, LLC
Harris Teeter NighttimeHarris Teeter, LLC
Harris Teeter Nighttime Cold and FluHarris Teeter, LLC
Health Mart Multi-symptom Cold and Flu Night TimeMc Kesson (Health Mart)
Health Mart Night Time Cold and FluMc Kesson
Healthy Accents Cold and CoughDZA Brands LLC
Healthy Accents Cough and Sore Throat Night TimeDZA Brands LLC
Healthy Accents Day Time Night TimeDZA Brands LLC
Healthy Accents Daytime Nighttime Cold and FluDZA Brands LLC
Healthy Accents Night Time CoughDZA Brands LLC
Healthy Accents Nighttime Cold and FluDZA Brands LLC
Leader Nite TimeCardinal Health
Leader Nite Time Cold Flu Relief Multi SymptomCardinal Health
Leader Nite Time CoughCardinal Health
Leader Nite Time Multi Symptom Cold and Flu ReliefCardinal Health
Leader Nite Time Multi Symptom Cold Flu ReliefCardinal Health
Leader Nite Time Severe Cold and FluCardinal Health
Leader Severe Sinus CongestionCardinal Health
Lortuss DMPoly Pharmaceuticals
Lortuss LqPoly Pharmaceuticals
Major Night Time Multi Symptom Cold and Flu ReliefMajor Pharmaceuticals
Maximum Strength Nighttime Cold/flu ReliefPura Cap Pharmaceutical Llc.
Mckesson Nite TimeMc Kesson
Mercodol With DecaprynAventis Pharma Inc
Mersyndol With CodeineSanofi Aventis Canada Inc
Mucinex Fast-max Day Severe Cold and Night Cold and FluReckitt Benckiser LLC
Mucinex Fast-max Night Time Cold and FluReckitt Benckiser LLC
Mucinex Sinus - Max Day / NightReckitt Benckiser LLC
Multi Symptom Nighttime Cold and Flu ReliefChain Drug Consortium, LLC
Multi Symptom NitetimeCare One (American Sales Company)
Multi-symptom Daytime and Nighttime Cold and Flu Relief PlusWalgreens Company
Multi-symptom Nighttime Sinus ReliefPura Vation Pharmaceuticals Inc
Multi-symptom NitetimeP And L Development Of New York Corporation (Ready In Case)
N - TimeSPIRIT PHARMACEUTICALS,LLC
N - Time SinusSPIRIT PHARMACEUTICALS,LLC
Neocitran Cold & Flu SyrupNovartis Consumer Health Canada Inc.
Next Night Time Cold and Flu ReliefGenomma Lab Usa
Nicold Medicine for AdultsTanta Pharmaceuticals Inc
Night Cold Flu Cough and AllergyHumanwell Pura Cap Pharmaceutical (Wuhan), Ltd.
Night ReliefWestern Family Foods Inc
Night Relief Cold and Flu Liquid CapsulesBanner Pharmacaps (Canada) Ltd.
Night Relief CoughWestern Family Foods Inc
Night Relief FreeWestern Family Foods Inc
Night Relief Multi Symptom Cold and FluWestern Family Foods Inc
Night Relief SinusWestern Family Foods, Inc.
Night TimeShopko Stores Operating Co., LLC
Night Time CherryDollar General
Night Time Cherry Pseudo-freeRite Aid
Night Time Cold and FluSafeway
Night Time Cold and Flu Multi SymptomH E B
Night Time Cold and Flu ReadyincaseP & L Development, LLC
Night Time Cold and Flu ReliefDolgencorp, Inc. (DOLLAR GENERAL & REXALL)
Night Time Cold and Flu Relief Multi SymptomFreds Inc
Night Time Cold and Flue ReliefAllegiant Health
Night Time Cold MaxDolgencorp, LLC
Night Time Cold/flu Relief CherryKareway Product, Inc.
Night Time Cold/flu Relief Multi SymptomShopko Stores Operating Co., LLC.
Night Time Cold/flu Relief OriginalKareway Product, Inc.
Night Time CoughSelect Brand Dist.
Night Time Cough and Sore Throat Cool BlastCVS
Night Time Cough CherryRite Aid
Night Time Cough ReliefH E B
Night Time Day Time Cold and FluHy Vee Inc
Night Time GelcapKareway Product, Inc.
Night Time Liquid Caps Cold Flu Multi SymptomH E B
Night Time Multi Symptom Cold/flu ReliefFreds Inc
Night Time Multi Symptom Flu Cold MedicineSalado Sales, Inc.
Night Time Multi Symptom ReliefPharma Strides Canada Corporation
Night Time Multi-symptom Cold/flu ReliefChain Drug Consortium, LLC
Night Time Original Pseudo-freeRite Aid
Night Time Pseudo-freeRite Aid
Night Time ReliefPharma Strides Canada Corporation
Night Time SinusFreds Inc
Night Time Sinus and CongestionChain Drug Consortium, LLC
Night Time SoftgelsPharma Strides Canada Corporation
Night-time Cherry Multi-symptom Cold/flu ReliefChain Drug Consortium, LLC
Night-time Cough ReliefDiscount Drug Mart
Night-time Multi-symptom Cold/flu CherryDe Moulas Market Basket
Night-time Multi-symptom Cold/flu OriginalDe Moulas Market Basket
Night-time Multi-symptom Cold/flu ReliefDiscount Drug Mart
Night-time Original Multi-symptom Cold/flu ReliefChain Drug Consortium, LLC
Nightcap Cold and Flu Liquid GelsAccucaps Industries Limited
Nightcap Complete Liquid GelsAccucaps Industries Limited
Nightrelief DayreliefWestern Family Foods Inc
Nightrelief Free Multi Symptom Cold FluWestern Family Foods Inc
NighttimeHannaford Brothers Company
Nighttime 325 Liqua CapsJamp Pharma Corporation
Nighttime Cold & Flu Liquid CapsulesVita Health Products Inc
Nighttime Cold & Flu ReliefApotex Inc
Nighttime Cold & Flu Relief SyrupPharmetics (2011) Inc
Nighttime Cold and FluShopko Stores Operating Co., LLC
Nighttime Cold and Flu CherrySelect Brand Dist.
Nighttime Cold and Flu Extra Strength MedicineJamp Pharma Corporation
Nighttime Cold and Flu Lil Drug Store ProductsLil' Drug Store Products, Inc
Nighttime Cold and Flu Liquid CapsulesVita Health Products Inc
Nighttime Cold and Flu Multi SymptomMc Kesson (Health Mart)
Nighttime Cold and Flu OriginalMarc Glassman, Inc.
Nighttime Cold and Flu ReadyincaseAaron Industries Inc.
Nighttime Cold and Flu ReliefWalgreen Company
Nighttime Cold and Flu Relief Multi-symptomFamily Dollar (FAMILY WELLNESS)
Nighttime Cold and Flu Relief PlusChain Drug Consortium,Llc
Nighttime Cold Flu ReliefLIVE BETTER (The Great Atlantic & Pacific Tea Company)
Nighttime Cold MedicineJamp Pharma Corporation
Nighttime Cold Multi-symptom Cool BlastAmerisource Bergen (Good Neighbor Pharmacy) 46122
Nighttime CoughWalgreen Company
Nighttime Cough All Night Cough ReliefAaron Industries Inc.
Nighttime Cough and Sore Throat LiquidJamp Pharma Corporation
Nighttime Cough ReliefRite Aid Corporation
Nighttime Cough. Cold. Flu Gel CapsulesApotex Inc., Private Label Division
Nighttime D Cold and FluHy Vee Inc
Nighttime D Cold and Flu ReliefWalgreen Company
Nighttime Daytime CoughWalgreen Company
Nighttime Liqua CapsJamp Pharma Corporation
Nighttime Multi SymptomCVS Pharmacy
Nighttime Multi Symptom Cold and Flu ReliefFamily Dollar (FAMILY WELLNESS)
Nighttime Multi-symptom Cold and Flu ReliefWALGREEN CO.
Nighttime Multi-symptom Flu ColdSalado Sales, Inc.
Nighttime Relief Severe Cold and FluFRED'S, INC.
Nighttime SevereShopko Stores Operating Co., LLC
Nighttime Severe Cold and FluH E B
Nighttime Severe Cold and Flu ReliefRite Aid Corporation
Nighttime SinusGood Sense (Geiss, Destin & Dunn, Inc.)
Nighttime Sinus Multi SymptomChain Drug Consortium, LLC
Nighttime Sinus ReliefHumanwell Pura Cap Pharmaceutical (Wuhan), Ltd.
Nite TimeKroger Company
Nite Time Cold and FluRite Aid Corporation
Nite Time Cold and Flu ReliefKroger Company
Nite Time Cold MedicineRij Pharmaceutical Corporation
Nite Time Cold Medicine Cherry FlavorRij Pharmaceutical Corporation
Nite Time Cold/flu ReliefOUR FAMILY (Nash Finch Company)
Nite Time Multi Symptom Cold Flu ReliefKroger Company
Nite Time Multi Symptom Cold/fluKroger Company
Nite Time Severe Cold and Flu Damaximum StrengthMeijer
Nite-time Cold and Flu Multi-symptom ReliefPreferred Plus (Kinray)
Nite-time Cold/flu OriginalSalado Sales, Inc.
Nite-timecold/flu Cherry Cold/flu CherrySalado Sales, Inc.
Nitecap Sinus Liquid GelsAccucaps Industries Limited
NitetimeKroger Company
Nitetime Cold and FluKroger Company
Nitetime Cold and Flu ReliefCare One (American Sales Company)
Nitetime Cold Flu ReliefMEIJER, INC.
Nitetime Cold MedicineIvc Industries, Hall Division
Nitetime Cold Medicine LiqJamp Pharma Corporation
Nitetime Cold Medicine Original and CherryWestcan Pharmaceuticals Ltd.
Nitetime Cold Plus Flu ReleifDolgencorp, Inc. (DOLLAR GENERAL & REXALL)
Nitetime Cold/flu, Multi-symptom ReliefWal Mart Stores Inc
Nitetime CoughKroger Company
Nitetime Cough Daytime CoughMeijer Distribution Inc
Nitetime DMeijer Distribution Inc
Nitetime D Multi Symptom Cold Flu ReliefMeijer Distribution Inc
Nitetime DaytimeKroger Company
Nitetime Daytime Cold and FluMeijer Distribution Inc
Nitetime Daytime Severe Cold and FluKroger Company
Nitetime Multi-symptom Cold/flu ReliefGREENBRIER INTERNATIONAL
Nitetime Severe Cold and FluKroger Company
Nitetime Severe Cold and Flu ReliefWestern Family Foods Inc
Nitetime SinusMEIJER, INC.
Nitetime Sinus ReliefTOP CARE (Topco Associates LLC)
Nyquil Cold and FluLil' Drug Store Products, Inc.
Nyquil LiquicapsProcter & Gamble Inc
Nyquil Sinus LiquicapsProcter & Gamble Inc
Original Night-time Multi-symptom Cold/flu ReliefDiscount Drug Mart
P.M. Cold Relief FormulaIvax Pharmaceuticals Incorporated
Poly Hist FortePoly Pharmaceuticals, Inc.
Preferred Plus Severe Nite TimeKinray
Preferred Plus Severe Sinus CongestionKinray
Publix Cherry Flavor NitetimePublix Super Markets Inc
Quality Choice Nighttime Cold and FluQUALITY CHOICE (Chain Drug Marketing Association)
Ratio-calmydoneTeva Canada Limited
Regular Strength Sinus MedicationVita Health Products Inc
Rexall Daytime Nighttime Cold and FluDolgencorp Inc
Rexall Daytime Nighttime Cold FluDolgencorp, LLC
Rexall Night Time Cold and FluDolgencorp Inc
Robitussin Complete NighttimePfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Robitussin Maximum Strength Nighttime Cough DMRichmond Division of Wyeth
Robitussin Peak Cold Nighttime Cold Plus FluRichmond Division of Wyeth
Rx Act Cough and Sore ThroatH E B
Rx Act Nighttime Cold Flu Relief Multi SymptomH E B
Safetussin PMKramer Laboratories
Safeway Nighttime Cold and FluSafeway, Inc.
Sanaflu Night-time Xtreme Multi-symptom Cold/flu Relief Cherry FlavorGrandall Distributing Co., Inc.
Sanatos NightPharmalab Enterprises Inc
Severe Cold and FluWalgreen Company
Severe Cold and Flu Night TimeHy Vee Inc
Severe Cold and Flu NighttimeTarget Corporation
Severe Cold and Flu Nighttime DaytimeHy Vee Inc
Severe Cold and Flu ReliefRite Aid Corporation
Severe Cold and Flu Relief NighttimeRite Aid Corporation
Severe NighttimeCVS Pharmacy
Severe Nighttime Severe DaytimeCVS Pharmacy
Severe Sinus CongestionKroger Company
Shoprite Ni CalmWakefern Food Corporation
Shoprite Ni Calm CoughWakefern Food Corporation
Signature Care Nighttime Severe Cold and Flu ReliefSafeway
Simply Right Night TimeSam's West Inc
Sinus Day/night Extra StrengthPharmetics (2011) Inc
Sinus MedicationVita Health Products Inc
Sinus Medication Day & NightVita Health Products Inc
Sinus Medication Extra Strength Night TimePharmascience Inc
Sinus Medication Night TabletsPharmetics (2011) Inc
Sinus NighttimeCare One (American Sales Company)
Sinus Relief Daytime NighttimeWALGREEN CO.
Smart Sense Daytime Nighttime Cold and FluKmart Corporation
Smart Sense NighttimeKmart Corporation
Smart Sense Nighttime Cold and FluKmart Corporation
Smart Sense Nighttime Cold and Flu Relief Multi SymptomKmart Corporation
Smart Sense Nighttime CoughKmart Corporation
Smart Sense Nighttime DaytimeKmart Corporation
Smart Sense Severe Cold and Flu NighttimeKmart Corporation
Smith Bros Night Time Cough and CongestionUniversal Holdings I Llc
Sound Body Cold and Flu ReliefBig Lots Stores, Inc.
Sunmark Nite TimeMcKesson
Sunmark Nite Time Cold and FluMc Kesson
Sunmark Nite Time CoughMc Kesson
Sunmark Nite Time D Cold and FluMc Kesson
Target Cold/flu ReliefTarget Corporation
Topcare Clear TimeTopco Associates LLC
Topcare Cold and CoughTopco Associates LLC
Topcare Cold MaxTopco Associates LLC
Topcare Cough and Sore ThroatTopco Associates LLC
Topcare Day Time Nite TimeTopco Associates LLC
Topcare Day Time Nite Time Cold and FluTopco Associates LLC
Topcare Day Time Nite Time Cold and Flu ReliefTopco Associates LLC
Topcare Daytime Nighttime Clear TimeTopco Associates LLC
Topcare Nite TimeTopco Associates LLC
Topcare Nite Time Cold and FluTopco Associates LLC
Topcare Nite Time Cold and Flu ReliefTopco Associates LLC
Topcare Nite Time Cold and Flu Relief Multi Symptom ReliefTopco Associates LLC
Topcare Nite Time CoughTopco Associates LLC
Topcare Nite Time DTopco Associates LLC
Topcare Nite Time Day Time Cold and FluTopco Associates LLC
Topcare Nite Time Day Time Cold and Flu ReliefTopco Associates LLC
Topcare Nite Time Multi Symptom ReliefTopco Associates LLC
Topcare Pain Relief Cold NightttimeTopco Associates LLC
Topcare Severe Sinus CongestionTopco Associates LLC
Tussin DM Maximum StrengthCVS Pharmacy
Tylenol Cold & Flu NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Tylenol Cold and Flu NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Tylenol Cold Max NightJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division
Tylenol Cold Multi-symptomJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division
Up and Up Cold and Flu ReliefTarget Corporation
Up and Up Cold and Flu Relief Multi Symptom Day and Night Combo PackTarget Corporation
Up and Up Cold Flu ReliefTarget Corporation
Up and Up Cold Flu Relief Day NightTarget Corporation
Up and Up Cold Flu Relief Multi Symptom NightTarget Corporation
Up and Up Daytime Nighttime Cold and FluTarget Corporation
Up and Up Nighttime Cold and FluTarget Corporation
Up and Up Nighttime Daytime Cold and FluTarget Corporation
Vicks Dayquil and Vicks Nyquil Cold and Flu Multi-symptom Relief/cold and Flu Nighttime ReliefProcter & Gamble Manufacturing Company
Vicks Dayquil and Vicks Nyquil Severe Cold and FluProcter & Gamble Manufacturing Company
Vicks Nyquil Adult Nighttime Colds MedicineProcter & Gamble Inc
Vicks Nyquil Cold & Flu Nighttime ReliefProcter & Gamble Inc
Vicks Nyquil Cold and FluMechanical Servants, Inc.
Vicks Nyquil Cold and Flu Nighttime ReliefThe Procter & Gamble Manufacturing Company
Vicks Nyquil Cold and Flu Nighttime Relief and Vicks Childrens Nyquil Cold and CoughThe Procter & Gamble Manufacturing Company
Vicks Nyquil Complete Cold & FluProcter & Gamble Inc
Vicks Nyquil Complete Cold & Flu CapletsProcter & Gamble Inc
Vicks Nyquil CoughThe Procter & Gamble Manufacturing Company
Vicks Nyquil D Cold and Flu Nighttime ReliefThe Procter & Gamble Manufacturing Company
Vicks Nyquil LiquicapsProcter & Gamble Inc
Vicks Nyquil Liquicaps Cold and Flu Multi-symptom ReliefProcter & Gamble Inc
Vicks Nyquil Severe Cold and FluProcter & Gamble Manufacturing Company
Vicks Nyquil Sinus LiquicapsProcter & Gamble Inc
Vicks Qlearquil Daytime Sinus and Congestion and Nighttime Sinus and CongestionThe Procter & Gamble Manufacturing Company
Vicks Qlearquil Nighttime Sinus and CongestionThe Procter & Gamble Manufacturing Company
Walgreen Nighttime Cold and Flu ReliefWalgreen Company
ZicamMatrixx Initiatives, Inc.
Zicam Multi-symptom Cold & Flu NighttimeZicam Llc
Salts
Name/CASStructureProperties
Doxylamine succinate
ThumbNot applicableDBSALT001402
Categories
UNII95QB77JKPL
CAS number469-21-6
WeightAverage: 270.3694
Monoisotopic: 270.173213336
Chemical FormulaC17H22N2O
InChI KeyInChIKey=HCFDWZZGGLSKEP-UHFFFAOYSA-N
InChI
InChI=1S/C17H22N2O/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16/h4-12H,13-14H2,1-3H3
IUPAC Name
dimethyl({2-[1-phenyl-1-(pyridin-2-yl)ethoxy]ethyl})amine
SMILES
CN(C)CCOC(C)(C1=CC=CC=C1)C1=CC=CC=N1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as benzylethers. These are aromatic ethers with the general formula ROCR' (R = alkyl, aryl; R'=benzene).
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBenzylethers
Direct ParentBenzylethers
Alternative Parents
Substituents
  • Benzylether
  • Pyridine
  • Heteroaromatic compound
  • Tertiary aliphatic amine
  • Tertiary amine
  • Azacycle
  • Organoheterocyclic compound
  • Ether
  • Dialkyl ether
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationUsed alone as a short-term sleep aid, in combination with other drugs as a night-time cold and allergy relief drug. Also used in combination with Vitamin B6 (pyridoxine) to prevent morning sickness in pregnant women.
PharmacodynamicsDoxylamine is an antihistamine commonly used as a sleep aid. This drug is also used to relieve symptoms of hay fever (allergic rhinitis), hives (rash or itching), and other allergic reactions. Doxylamine is a member of the ethanolamine class of antihistamines and has anti-allergy power far superior to virtually every other antihistamine on the market, with the exception of diphenhydramine (Benadryl). It is also the most powerful over-the-counter sedative available in the United States, and more sedating than many prescription hypnotics. In a study, it was found to be superior to even the barbiturate, phenobarbital for use as a sedative. Doxylamine is also a potent anticholinergic.
Mechanism of actionLike other antihistamines, doxylamine acts by competitively inhibiting histamine at H1 receptors. It also has substantial sedative and anticholinergic effects.
Related Articles
AbsorptionReadily absorbed via the gastrointestinal tract.
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Hepatic.

Route of eliminationNot Available
Half life10 hours
ClearanceNot Available
ToxicitySigns of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, swelling of face, lips, tongue, or throat.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9505
Blood Brain Barrier+0.9491
Caco-2 permeable+0.746
P-glycoprotein substrateSubstrate0.7449
P-glycoprotein inhibitor INon-inhibitor0.5123
P-glycoprotein inhibitor IINon-inhibitor0.8383
Renal organic cation transporterInhibitor0.7507
CYP450 2C9 substrateNon-substrate0.8153
CYP450 2D6 substrateNon-substrate0.5432
CYP450 3A4 substrateSubstrate0.6801
CYP450 1A2 substrateNon-inhibitor0.9092
CYP450 2C9 inhibitorNon-inhibitor0.8957
CYP450 2D6 inhibitorInhibitor0.8361
CYP450 2C19 inhibitorNon-inhibitor0.8764
CYP450 3A4 inhibitorNon-inhibitor0.6894
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.736
Ames testNon AMES toxic0.9133
CarcinogenicityNon-carcinogens0.9183
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.9218 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8765
hERG inhibition (predictor II)Inhibitor0.5398
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Kit
Tablet, effervescentoral
Powder, for solutionoral
Kit; capsuleoral
Capsuleoral
Tablet, film coatedoral
Kitoral
Tablet (delayed-release)oral
Tablet, delayed releaseoral
Capsule, gelatin coatedoral
Solutionoral
Tabletoral25 mg/1
Syruporal
Tabletoral
Liquidoral
Capsule, liquid filledoral
Syruporal9.75 mg/5mL
Kit; tabletoral
Tabletoral25 mg
Tablet, coatedoral
Prices
Unit descriptionCostUnit
Doxylamine succinate powder1.5USD g
Unisom sleep aid tablet0.34USD tablet
Sleep aid 25 mg tablet0.15USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6340695 No2001-06-212021-06-21Us
US7560122 No1999-01-252019-01-25Us
Properties
StateLiquid
Experimental Properties
PropertyValueSource
melting point< 25 °CPhysProp
boiling point139 °C at 5.00E-01 mm HgPhysProp
water solubility1 g/ml (succinate salt)Not Available
logP2.5Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.541 mg/mLALOGPS
logP2.9ALOGPS
logP2.96ChemAxon
logS-2.7ALOGPS
pKa (Strongest Basic)8.87ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area25.36 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity82.24 m3·mol-1ChemAxon
Polarizability31.09 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-0040-0956300000-af11cf85a674e7db3735View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-001i-0910000000-b3cb895f045d519f2bf3View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-00kb-5597500000-8495062a84b32e776f33View in MoNA
MSMass Spectrum (Electron Ionization)splash10-0ab9-9200000000-5a71de62862f9881c2a1View in MoNA
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesR06AA59R06AA09
AHFS Codes
  • 04:04.04
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (74 KB)
Interactions
Drug Interactions
Drug
3,4-Methylenedioxyamphetamine3,4-Methylenedioxyamphetamine may decrease the sedative activities of Doxylamine.
3,4-Methylenedioxymethamphetamine3,4-Methylenedioxymethamphetamine may decrease the sedative activities of Doxylamine.
7-NitroindazoleDoxylamine may increase the central nervous system depressant (CNS depressant) activities of 7-Nitroindazole.
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Doxylamine.
7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE may increase the anticholinergic activities of Doxylamine.
AcepromazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Acepromazine.
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Doxylamine.
AceprometazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Aceprometazine.
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Doxylamine.
adipiplonDoxylamine may increase the central nervous system depressant (CNS depressant) activities of adipiplon.
adipiplonThe risk or severity of adverse effects can be increased when adipiplon is combined with Doxylamine.
AgomelatineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Agomelatine.
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Doxylamine.
AlfaxaloneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Alfaxalone.
AlfaxaloneThe risk or severity of adverse effects can be increased when Alfaxalone is combined with Doxylamine.
AlfentanilDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Alfentanil.
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Doxylamine.
AlphacetylmethadolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Alphacetylmethadol.
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Doxylamine.
AlprazolamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Alprazolam.
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Doxylamine.
AmisulprideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Amisulpride.
AmisulprideThe risk or severity of adverse effects can be increased when Amisulpride is combined with Doxylamine.
AmitriptylineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
AmitriptylineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Doxylamine.
AmobarbitalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Amobarbital.
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Doxylamine.
AmoxapineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Amoxapine.
AmoxapineThe risk or severity of adverse effects can be increased when Amoxapine is combined with Doxylamine.
AmperozideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Amperozide.
AmperozideThe risk or severity of adverse effects can be increased when Amperozide is combined with Doxylamine.
AmphetamineAmphetamine may decrease the sedative activities of Doxylamine.
AripiprazoleDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Aripiprazole.
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Doxylamine.
ArticaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Articaine.
ArticaineThe risk or severity of adverse effects can be increased when Articaine is combined with Doxylamine.
AsenapineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Asenapine.
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Doxylamine.
AzaperoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Azaperone.
AzaperoneThe risk or severity of adverse effects can be increased when Azaperone is combined with Doxylamine.
AzelastineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Doxylamine.
BaclofenDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Baclofen.
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Doxylamine.
BarbitalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Barbital.
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Doxylamine.
BenmoxinBenmoxin may increase the anticholinergic activities of Doxylamine.
BenzocaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Benzocaine.
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Doxylamine.
BenzphetamineBenzphetamine may decrease the sedative activities of Doxylamine.
Benzyl alcoholDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Benzyl alcohol.
Benzyl alcoholThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Doxylamine.
Benzylpenicilloyl PolylysineDoxylamine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
BetahistineThe therapeutic efficacy of Betahistine can be decreased when used in combination with Doxylamine.
BrexpiprazoleDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Brexpiprazole.
BrexpiprazoleThe risk or severity of adverse effects can be increased when Brexpiprazole is combined with Doxylamine.
BrimonidineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Brimonidine.
BromazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Bromazepam.
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Doxylamine.
BrompheniramineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Brompheniramine.
BrompheniramineThe risk or severity of adverse effects can be increased when Brompheniramine is combined with Doxylamine.
BrotizolamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Brotizolam.
BrotizolamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Doxylamine.
BupivacaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Bupivacaine.
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Doxylamine.
BuprenorphineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
BuprenorphineThe risk or severity of adverse effects can be increased when Buprenorphine is combined with Doxylamine.
BuspironeDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Buspirone.
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Doxylamine.
ButabarbitalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Butabarbital.
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Doxylamine.
ButacaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Butacaine.
ButacaineThe risk or severity of adverse effects can be increased when Butacaine is combined with Doxylamine.
ButalbitalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Butalbital.
ButalbitalThe risk or severity of adverse effects can be increased when Butalbital is combined with Doxylamine.
ButambenDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Butamben.
ButambenThe risk or severity of adverse effects can be increased when Butamben is combined with Doxylamine.
ButethalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Butethal.
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Doxylamine.
ButorphanolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Butorphanol.
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Doxylamine.
CarbamazepineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Carbamazepine.
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Doxylamine.
CarbinoxamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Carbinoxamine.
CarbinoxamineThe risk or severity of adverse effects can be increased when Carbinoxamine is combined with Doxylamine.
CarfentanilDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Doxylamine.
CarisoprodolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Carisoprodol.
CarisoprodolThe risk or severity of adverse effects can be increased when Carisoprodol is combined with Doxylamine.
CaroxazoneCaroxazone may increase the anticholinergic activities of Doxylamine.
CetirizineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Cetirizine.
CetirizineThe risk or severity of adverse effects can be increased when Cetirizine is combined with Doxylamine.
Chloral hydrateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Doxylamine.
ChlordiazepoxideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Doxylamine.
ChlormezanoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlormezanone.
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Doxylamine.
ChloroprocaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Chloroprocaine.
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Doxylamine.
ChlorphenamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.
ChlorphenamineThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Doxylamine.
ChlorphentermineChlorphentermine may decrease the sedative activities of Doxylamine.
ChlorpromazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlorpromazine.
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Doxylamine.
ChlorprothixeneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlorprothixene.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Doxylamine.
ChlorzoxazoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone.
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Doxylamine.
CinchocaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Cinchocaine.
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Doxylamine.
CitalopramThe risk or severity of adverse effects can be increased when Doxylamine is combined with Citalopram.
ClemastineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Clemastine.
ClemastineThe risk or severity of adverse effects can be increased when Clemastine is combined with Doxylamine.
ClidiniumDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Clidinium.
ClidiniumThe risk or severity of adverse effects can be increased when Clidinium is combined with Doxylamine.
ClobazamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Clobazam.
ClobazamThe risk or severity of adverse effects can be increased when Clobazam is combined with Doxylamine.
clomethiazoleDoxylamine may increase the central nervous system depressant (CNS depressant) activities of clomethiazole.
clomethiazoleThe risk or severity of adverse effects can be increased when clomethiazole is combined with Doxylamine.
ClomipramineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Clomipramine.
ClomipramineThe risk or severity of adverse effects can be increased when Clomipramine is combined with Doxylamine.
ClonazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Clonazepam.
ClonazepamThe risk or severity of adverse effects can be increased when Clonazepam is combined with Doxylamine.
ClonidineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Clonidine.
ClonidineThe risk or severity of adverse effects can be increased when Clonidine is combined with Doxylamine.
ClorazepateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Clorazepate.
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Doxylamine.
ClozapineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Clozapine.
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Doxylamine.
CocaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Cocaine.
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Doxylamine.
CodeineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Codeine.
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Doxylamine.
CyclizineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Cyclizine.
CyclizineThe risk or severity of adverse effects can be increased when Cyclizine is combined with Doxylamine.
CyclobenzaprineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Cyclobenzaprine.
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Doxylamine.
CyproheptadineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine.
CyproheptadineThe risk or severity of adverse effects can be increased when Cyproheptadine is combined with Doxylamine.
DantroleneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dantrolene.
DantroleneThe risk or severity of adverse effects can be increased when Dantrolene is combined with Doxylamine.
DapiprazoleDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dapiprazole.
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Doxylamine.
DapoxetineThe risk or severity of adverse effects can be increased when Doxylamine is combined with Dapoxetine.
deramciclaneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of deramciclane.
deramciclaneThe risk or severity of adverse effects can be increased when deramciclane is combined with Doxylamine.
DesfluraneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Desflurane.
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Doxylamine.
DesipramineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
DesipramineThe risk or severity of adverse effects can be increased when Desipramine is combined with Doxylamine.
DesloratadineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Desloratadine.
DesloratadineThe risk or severity of adverse effects can be increased when Desloratadine is combined with Doxylamine.
DetomidineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Detomidine.
DetomidineThe risk or severity of adverse effects can be increased when Detomidine is combined with Doxylamine.
DexbrompheniramineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dexbrompheniramine.
DexbrompheniramineThe risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Doxylamine.
DexmedetomidineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dexmedetomidine.
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Doxylamine.
DextroamphetamineDextroamphetamine may decrease the sedative activities of Doxylamine.
DextromoramideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dextromoramide.
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Doxylamine.
DextropropoxypheneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dextropropoxyphene.
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Doxylamine.
DezocineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dezocine.
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Doxylamine.
DiazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Diazepam.
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Doxylamine.
DifenoxinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Difenoxin.
DifenoxinThe risk or severity of adverse effects can be increased when Difenoxin is combined with Doxylamine.
DihydrocodeineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dihydrocodeine.
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Doxylamine.
DihydroetorphineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dihydroetorphine.
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Doxylamine.
DihydromorphineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dihydromorphine.
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Doxylamine.
DimenhydrinateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dimenhydrinate.
DimenhydrinateThe risk or severity of adverse effects can be increased when Dimenhydrinate is combined with Doxylamine.
DiphenhydramineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Doxylamine.
DiphenoxylateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Diphenoxylate.
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Doxylamine.
DoramectinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Doramectin.
DoramectinThe risk or severity of adverse effects can be increased when Doramectin is combined with Doxylamine.
DoxepinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
DoxepinThe risk or severity of adverse effects can be increased when Doxepin is combined with Doxylamine.
DPDPEDoxylamine may increase the central nervous system depressant (CNS depressant) activities of DPDPE.
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Doxylamine.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.
DroperidolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Droperidol.
DroperidolThe risk or severity of adverse effects can be increased when Droperidol is combined with Doxylamine.
DrotebanolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Drotebanol.
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Doxylamine.
DyclonineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dyclonine.
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Doxylamine.
EcgonineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ecgonine.
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Doxylamine.
ECGONINE METHYL ESTERDoxylamine may increase the central nervous system depressant (CNS depressant) activities of ECGONINE METHYL ESTER.
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when ECGONINE METHYL ESTER is combined with Doxylamine.
EfavirenzDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Efavirenz.
EfavirenzThe risk or severity of adverse effects can be increased when Efavirenz is combined with Doxylamine.
EnfluraneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Enflurane.
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Doxylamine.
EntacaponeDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Entacapone.
EntacaponeThe risk or severity of adverse effects can be increased when Entacapone is combined with Doxylamine.
EscitalopramThe risk or severity of adverse effects can be increased when Doxylamine is combined with Escitalopram.
EstazolamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Estazolam.
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Doxylamine.
EszopicloneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Eszopiclone.
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Doxylamine.
EthanolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthchlorvynolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ethchlorvynol.
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Doxylamine.
EthosuximideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ethosuximide.
EthosuximideThe risk or severity of adverse effects can be increased when Ethosuximide is combined with Doxylamine.
EthotoinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ethotoin.
EthotoinThe risk or severity of adverse effects can be increased when Ethotoin is combined with Doxylamine.
Ethyl carbamateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ethyl carbamate.
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Doxylamine.
Ethyl loflazepateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ethyl loflazepate.
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Doxylamine.
EthylmorphineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ethylmorphine.
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Doxylamine.
EtidocaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Etidocaine.
EtidocaineThe risk or severity of adverse effects can be increased when Etidocaine is combined with Doxylamine.
EtifoxineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Etifoxine.
EtifoxineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Doxylamine.
EtizolamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Etizolam.
EtizolamThe risk or severity of adverse effects can be increased when Etizolam is combined with Doxylamine.
EtomidateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Etomidate.
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Doxylamine.
EtoperidoneThe risk or severity of adverse effects can be increased when Doxylamine is combined with Etoperidone.
EtorphineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Etorphine.
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Doxylamine.
EzogabineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ezogabine.
EzogabineThe risk or severity of adverse effects can be increased when Ezogabine is combined with Doxylamine.
FelbamateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Felbamate.
FelbamateThe risk or severity of adverse effects can be increased when Felbamate is combined with Doxylamine.
FencamfamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Fencamfamine.
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Doxylamine.
FenfluramineThe risk or severity of adverse effects can be increased when Doxylamine is combined with Fenfluramine.
FentanylDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Doxylamine.
FexofenadineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.
FexofenadineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Doxylamine.
FlibanserinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Flibanserin.
FlibanserinThe risk or severity of adverse effects can be increased when Flibanserin is combined with Doxylamine.
FludiazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Fludiazepam.
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Doxylamine.
FlunarizineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Flunarizine.
FlunarizineThe risk or severity of adverse effects can be increased when Flunarizine is combined with Doxylamine.
FlunitrazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Flunitrazepam.
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Doxylamine.
FluoxetineThe risk or severity of adverse effects can be increased when Doxylamine is combined with Fluoxetine.
FlupentixolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Flupentixol.
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Doxylamine.
FluphenazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Fluphenazine.
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Doxylamine.
FlurazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Flurazepam.
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Doxylamine.
FluspirileneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Fluspirilene.
FluspirileneThe risk or severity of adverse effects can be increased when Fluspirilene is combined with Doxylamine.
Fluticasone PropionateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Fluticasone Propionate.
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Doxylamine.
FluvoxamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Fluvoxamine.
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Doxylamine.
FosphenytoinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Fosphenytoin.
FosphenytoinThe risk or severity of adverse effects can be increased when Fosphenytoin is combined with Doxylamine.
FospropofolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Fospropofol.
FospropofolThe risk or severity of adverse effects can be increased when Fospropofol is combined with Doxylamine.
FurazolidoneFurazolidone may increase the anticholinergic activities of Doxylamine.
GabapentinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Gabapentin.
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Doxylamine.
gabapentin enacarbilDoxylamine may increase the central nervous system depressant (CNS depressant) activities of gabapentin enacarbil.
gabapentin enacarbilThe risk or severity of adverse effects can be increased when gabapentin enacarbil is combined with Doxylamine.
Gamma Hydroxybutyric AcidDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Gamma Hydroxybutyric Acid.
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Doxylamine.
GlutethimideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Doxylamine.
GuanfacineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Guanfacine.
GuanfacineThe risk or severity of adverse effects can be increased when Guanfacine is combined with Doxylamine.
HalazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Halazepam.
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Doxylamine.
HaloperidolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Haloperidol.
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Doxylamine.
HalothaneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Halothane.
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Doxylamine.
HeroinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Heroin.
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Doxylamine.
HexobarbitalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Hexobarbital.
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Doxylamine.
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Doxylamine.
HydracarbazineHydracarbazine may increase the anticholinergic activities of Doxylamine.
HydrocodoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
HydrocodoneThe risk or severity of adverse effects can be increased when Hydrocodone is combined with Doxylamine.
HydromorphoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Hydromorphone.
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Doxylamine.
Hydroxyamphetamine hydrobromideHydroxyamphetamine hydrobromide may decrease the sedative activities of Doxylamine.
HydroxyzineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Hydroxyzine.
IloperidoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Iloperidone.
IloperidoneThe risk or severity of adverse effects can be increased when Iloperidone is combined with Doxylamine.
ImipramineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Imipramine.
ImipramineThe risk or severity of adverse effects can be increased when Imipramine is combined with Doxylamine.
IndalpineThe risk or severity of adverse effects can be increased when Doxylamine is combined with Indalpine.
IproclozideIproclozide may increase the anticholinergic activities of Doxylamine.
IproniazidIproniazid may increase the anticholinergic activities of Doxylamine.
IsocarboxazidIsocarboxazid may increase the anticholinergic activities of Doxylamine.
IsofluraneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Isoflurane.
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Doxylamine.
KetamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ketamine.
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Doxylamine.
KetazolamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ketazolam.
KetazolamThe risk or severity of adverse effects can be increased when Ketazolam is combined with Doxylamine.
KetobemidoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ketobemidone.
KetobemidoneThe risk or severity of adverse effects can be increased when Ketobemidone is combined with Doxylamine.
LamotrigineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.
LamotrigineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Doxylamine.
LevetiracetamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.
LevetiracetamThe risk or severity of adverse effects can be increased when Levetiracetam is combined with Doxylamine.
LevobupivacaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Levobupivacaine.
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Doxylamine.
LevocabastineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Levocabastine.
LevocabastineThe risk or severity of adverse effects can be increased when Levocabastine is combined with Doxylamine.
LevocetirizineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Levocetirizine.
LevocetirizineThe risk or severity of adverse effects can be increased when Levocetirizine is combined with Doxylamine.
LevodopaDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Levodopa.
LevodopaThe risk or severity of adverse effects can be increased when Levodopa is combined with Doxylamine.
Levomethadyl AcetateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Levomethadyl Acetate.
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Doxylamine.
LevomilnacipranThe risk or severity of adverse effects can be increased when Doxylamine is combined with Levomilnacipran.
LevorphanolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Levorphanol.
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Doxylamine.
LidocaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Lidocaine.
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Doxylamine.
LisdexamfetamineLisdexamfetamine may decrease the sedative activities of Doxylamine.
LithiumDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Lithium.
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Doxylamine.
LofentanilDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Lofentanil.
LofentanilThe risk or severity of adverse effects can be increased when Lofentanil is combined with Doxylamine.
LoratadineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Loratadine.
LoratadineThe risk or severity of adverse effects can be increased when Loratadine is combined with Doxylamine.
LorazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Doxylamine.
LoxapineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Loxapine.
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Doxylamine.
Lu AA21004Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Lu AA21004.
Lu AA21004The risk or severity of adverse effects can be increased when Lu AA21004 is combined with Doxylamine.
LurasidoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Lurasidone.
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with Doxylamine.
Magnesium SulfateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Magnesium Sulfate.
MaprotilineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Maprotiline.
MaprotilineThe risk or severity of adverse effects can be increased when Maprotiline is combined with Doxylamine.
MebanazineMebanazine may increase the anticholinergic activities of Doxylamine.
MeclizineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Meclizine.
MeclizineThe risk or severity of adverse effects can be increased when Meclizine is combined with Doxylamine.
MedetomidineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Medetomidine.
MedetomidineThe risk or severity of adverse effects can be increased when Medetomidine is combined with Doxylamine.
MelatoninDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Melatonin.
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Doxylamine.
MelperoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Melperone.
MelperoneThe risk or severity of adverse effects can be increased when Melperone is combined with Doxylamine.
MephentermineMephentermine may decrease the sedative activities of Doxylamine.
MepivacaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Mepivacaine.
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Doxylamine.
MeprobamateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Meprobamate.
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Doxylamine.
MesoridazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Mesoridazine.
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Doxylamine.
MetaxaloneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Metaxalone.
MetaxaloneThe risk or severity of adverse effects can be increased when Metaxalone is combined with Doxylamine.
MethadoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Methadone.
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Doxylamine.
Methadyl AcetateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Methadyl Acetate.
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Doxylamine.
MethamphetamineMethamphetamine may decrease the sedative activities of Doxylamine.
MethapyrileneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Methapyrilene.
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Doxylamine.
MethaqualoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Methaqualone.
MethaqualoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Doxylamine.
MethocarbamolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Methocarbamol.
MethocarbamolThe risk or severity of adverse effects can be increased when Methocarbamol is combined with Doxylamine.
MethohexitalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Methohexital.
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Doxylamine.
MethotrimeprazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Methotrimeprazine is combined with Doxylamine.
MethoxyfluraneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Methoxyflurane.
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Doxylamine.
MethsuximideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Methsuximide.
MethsuximideThe risk or severity of adverse effects can be increased when Methsuximide is combined with Doxylamine.
Methylene blueMethylene blue may increase the anticholinergic activities of Doxylamine.
MethylphenobarbitalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Methylphenobarbital.
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Doxylamine.
MetyrosineDoxylamine may increase the sedative activities of Metyrosine.
MidazolamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Midazolam.
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Doxylamine.
MilnacipranThe risk or severity of adverse effects can be increased when Doxylamine is combined with Milnacipran.
MinaprineMinaprine may increase the anticholinergic activities of Doxylamine.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.
MirtazapineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MirtazapineThe risk or severity of adverse effects can be increased when Mirtazapine is combined with Doxylamine.
MoclobemideMoclobemide may increase the anticholinergic activities of Doxylamine.
MolindoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Molindone.
MolindoneThe risk or severity of adverse effects can be increased when Molindone is combined with Doxylamine.
MorphineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Morphine.
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Doxylamine.
NabiloneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.
NalbuphineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Nalbuphine.
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Doxylamine.
NialamideNialamide may increase the anticholinergic activities of Doxylamine.
NitrazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Nitrazepam.
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Doxylamine.
Nitrous oxideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Doxylamine.
NormethadoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Normethadone.
NormethadoneThe risk or severity of adverse effects can be increased when Normethadone is combined with Doxylamine.
NortriptylineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Nortriptyline.
NortriptylineThe risk or severity of adverse effects can be increased when Nortriptyline is combined with Doxylamine.
OctamoxinOctamoxin may increase the anticholinergic activities of Doxylamine.
OlanzapineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Olanzapine.
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Doxylamine.
OlopatadineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Olopatadine.
OlopatadineThe risk or severity of adverse effects can be increased when Olopatadine is combined with Doxylamine.
OndansetronDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ondansetron.
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Doxylamine.
OpiumDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Opium.
OpiumThe risk or severity of adverse effects can be increased when Opium is combined with Doxylamine.
OrphenadrineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OrphenadrineThe risk or severity of adverse effects can be increased when Orphenadrine is combined with Doxylamine.
OsanetantDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Osanetant.
OsanetantThe risk or severity of adverse effects can be increased when Osanetant is combined with Doxylamine.
OxazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Oxazepam.
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Doxylamine.
OxprenololDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Oxprenolol.
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Doxylamine.
OxybuprocaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Oxybuprocaine.
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Doxylamine.
OxycodoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Doxylamine.
OxymorphoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Oxymorphone.
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Doxylamine.
PaliperidoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Paliperidone.
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Doxylamine.
ParaldehydeDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParaldehydeThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Doxylamine.
PargylinePargyline may increase the anticholinergic activities of Doxylamine.
ParoxetineThe risk or severity of adverse effects can be increased when Doxylamine is combined with Paroxetine.
PentazocineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pentazocine.
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Doxylamine.
PentobarbitalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pentobarbital.
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Doxylamine.
PerampanelDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.
PerampanelThe risk or severity of adverse effects can be increased when Perampanel is combined with Doxylamine.
PerospironeDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Perospirone.
PerospironeThe risk or severity of adverse effects can be increased when Perospirone is combined with Doxylamine.
PerphenazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Perphenazine.
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Doxylamine.
PethidineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pethidine.
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Doxylamine.
PhenelzinePhenelzine may increase the anticholinergic activities of Doxylamine.
PheniprazinePheniprazine may increase the anticholinergic activities of Doxylamine.
PhenobarbitalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Phenobarbital.
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Doxylamine.
PhenoxyethanolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Phenoxyethanol.
PhenoxyethanolThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Doxylamine.
PhenoxypropazinePhenoxypropazine may increase the anticholinergic activities of Doxylamine.
PhenterminePhentermine may decrease the sedative activities of Doxylamine.
PhenytoinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Phenytoin.
PhenytoinThe risk or severity of adverse effects can be increased when Phenytoin is combined with Doxylamine.
PimozideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pimozide.
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Doxylamine.
PipamperoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pipamperone.
PipamperoneThe risk or severity of adverse effects can be increased when Pipamperone is combined with Doxylamine.
PipotiazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pipotiazine.
PipotiazineThe risk or severity of adverse effects can be increased when Pipotiazine is combined with Doxylamine.
PirlindolePirlindole may increase the anticholinergic activities of Doxylamine.
PivhydrazinePivhydrazine may increase the anticholinergic activities of Doxylamine.
PizotifenDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pizotifen.
PizotifenThe risk or severity of adverse effects can be increased when Pizotifen is combined with Doxylamine.
PomalidomideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pomalidomide.
PomalidomideThe risk or severity of adverse effects can be increased when Pomalidomide is combined with Doxylamine.
PramipexoleDoxylamine may increase the sedative activities of Pramipexole.
PramocaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pramocaine.
PramocaineThe risk or severity of adverse effects can be increased when Pramocaine is combined with Doxylamine.
PrazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Prazepam.
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with Doxylamine.
PregabalinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Doxylamine.
PrilocaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Prilocaine.
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Doxylamine.
PrimidoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Primidone.
PrimidoneThe risk or severity of adverse effects can be increased when Primidone is combined with Doxylamine.
ProcaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Procaine.
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Doxylamine.
ProchlorperazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Prochlorperazine.
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Doxylamine.
PromazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Promazine.
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Doxylamine.
PromethazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Promethazine.
PromethazineThe risk or severity of adverse effects can be increased when Promethazine is combined with Doxylamine.
ProparacaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Proparacaine.
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Doxylamine.
PropofolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Propofol.
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Doxylamine.
PropoxycaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Propoxycaine.
PropoxycaineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Doxylamine.
ProtriptylineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Protriptyline.
ProtriptylineThe risk or severity of adverse effects can be increased when Protriptyline is combined with Doxylamine.
PSD502Doxylamine may increase the central nervous system depressant (CNS depressant) activities of PSD502.
PSD502The risk or severity of adverse effects can be increased when PSD502 is combined with Doxylamine.
QuazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Quazepam.
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Doxylamine.
QuetiapineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Quetiapine.
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Doxylamine.
RamelteonDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.
RamelteonThe risk or severity of adverse effects can be increased when Ramelteon is combined with Doxylamine.
RasagilineRasagiline may increase the anticholinergic activities of Doxylamine.
RemifentanilDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Remifentanil.
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Doxylamine.
RemoxiprideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Remoxipride.
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Doxylamine.
ReserpineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Reserpine.
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Doxylamine.
RisperidoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Risperidone.
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Doxylamine.
RomifidineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Romifidine.
RomifidineThe risk or severity of adverse effects can be increased when Romifidine is combined with Doxylamine.
RopiniroleDoxylamine may increase the sedative activities of Ropinirole.
RopivacaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ropivacaine.
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Doxylamine.
RotigotineDoxylamine may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Doxylamine.
S-EthylisothioureaDoxylamine may increase the central nervous system depressant (CNS depressant) activities of S-Ethylisothiourea.
S-EthylisothioureaThe risk or severity of adverse effects can be increased when S-Ethylisothiourea is combined with Doxylamine.
SafrazineSafrazine may increase the anticholinergic activities of Doxylamine.
ScopolamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Scopolamine.
ScopolamineThe risk or severity of adverse effects can be increased when Scopolamine is combined with Doxylamine.
SecobarbitalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Secobarbital.
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Doxylamine.
SelegilineSelegiline may increase the anticholinergic activities of Doxylamine.
SertindoleDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Sertindole.
SertindoleThe risk or severity of adverse effects can be increased when Sertindole is combined with Doxylamine.
SertralineThe risk or severity of adverse effects can be increased when Doxylamine is combined with Sertraline.
SevofluraneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Sevoflurane.
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Doxylamine.
Sodium oxybateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Sodium oxybateThe risk or severity of adverse effects can be increased when Sodium oxybate is combined with Doxylamine.
StiripentolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Stiripentol.
StiripentolThe risk or severity of adverse effects can be increased when Stiripentol is combined with Doxylamine.
SufentanilDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Sufentanil.
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Doxylamine.
SulpirideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Sulpiride.
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Doxylamine.
SuvorexantDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
SuvorexantThe risk or severity of adverse effects can be increased when Suvorexant is combined with Doxylamine.
TapentadolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.
TapentadolThe risk or severity of adverse effects can be increased when Tapentadol is combined with Doxylamine.
TasimelteonDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.
TasimelteonThe risk or severity of adverse effects can be increased when Tasimelteon is combined with Doxylamine.
TemazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Temazepam.
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Doxylamine.
TetrabenazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Tetrabenazine.
TetrabenazineThe risk or severity of adverse effects can be increased when Tetrabenazine is combined with Doxylamine.
TetracaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Tetracaine.
TetracaineThe risk or severity of adverse effects can be increased when Tetracaine is combined with Doxylamine.
TetrodotoxinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Tetrodotoxin.
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Doxylamine.
ThalidomideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Doxylamine.
ThiamylalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Thiamylal.
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Doxylamine.
ThiopentalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Thiopental.
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Doxylamine.
ThioridazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Thioridazine.
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Doxylamine.
ThiothixeneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Thiothixene.
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Doxylamine.
TiagabineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Tiagabine.
TiagabineThe risk or severity of adverse effects can be increased when Tiagabine is combined with Doxylamine.
TiletamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Tiletamine.
TiletamineThe risk or severity of adverse effects can be increased when Tiletamine is combined with Doxylamine.
TizanidineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Tizanidine.
TizanidineThe risk or severity of adverse effects can be increased when Tizanidine is combined with Doxylamine.
TolcaponeDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Tolcapone.
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Doxylamine.
ToloxatoneToloxatone may increase the anticholinergic activities of Doxylamine.
TopiramateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Topiramate.
TopiramateThe risk or severity of adverse effects can be increased when Topiramate is combined with Doxylamine.
TramadolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Tramadol.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Doxylamine.
Trans-2-PhenylcyclopropylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Trans-2-Phenylcyclopropylamine.
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the anticholinergic activities of Doxylamine.
TranylcypromineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Tranylcypromine.
TranylcypromineTranylcypromine may increase the anticholinergic activities of Doxylamine.
TrazodoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Trazodone.
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Doxylamine.
TriazolamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Triazolam.
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Doxylamine.
TrifluoperazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Trifluoperazine.
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Doxylamine.
TriflupromazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Triflupromazine.
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Doxylamine.
TrimipramineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.
TrimipramineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Doxylamine.
TriprolidineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Triprolidine.
TriprolidineThe risk or severity of adverse effects can be increased when Triprolidine is combined with Doxylamine.
Valproic AcidDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Valproic Acid.
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Doxylamine.
VigabatrinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Vigabatrin.
VigabatrinThe risk or severity of adverse effects can be increased when Vigabatrin is combined with Doxylamine.
VilazodoneThe risk or severity of adverse effects can be increased when Doxylamine is combined with Vilazodone.
VortioxetineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine.
VortioxetineThe risk or severity of adverse effects can be increased when Vortioxetine is combined with Doxylamine.
XylazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Xylazine.
XylazineThe risk or severity of adverse effects can be increased when Xylazine is combined with Doxylamine.
ZaleplonDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Zaleplon.
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Doxylamine.
ZiconotideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ziconotide.
ZiconotideThe risk or severity of adverse effects can be increased when Ziconotide is combined with Doxylamine.
ZimelidineThe risk or severity of adverse effects can be increased when Doxylamine is combined with Zimelidine.
ZiprasidoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ziprasidone.
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Doxylamine.
ZolazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Zolazepam.
ZolazepamThe risk or severity of adverse effects can be increased when Zolazepam is combined with Doxylamine.
ZolpidemDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
ZolpidemThe risk or severity of adverse effects can be increased when Zolpidem is combined with Doxylamine.
ZonisamideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Zonisamide.
ZonisamideThe risk or severity of adverse effects can be increased when Zonisamide is combined with Doxylamine.
ZopicloneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Zopiclone.
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Doxylamine.
ZotepineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Zotepine.
ZotepineThe risk or severity of adverse effects can be increased when Zotepine is combined with Doxylamine.
ZuclopenthixolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Zuclopenthixol.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Doxylamine.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Histamine receptor activity
Specific Function:
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Gene Name:
HRH1
Uniprot ID:
P35367
Molecular Weight:
55783.61 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Phosphatidylinositol phospholipase c activity
Specific Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Gene Name:
CHRM1
Uniprot ID:
P11229
Molecular Weight:
51420.375 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Not Available
Gene Name:
CYP2B
Uniprot ID:
Q14097
Molecular Weight:
43147.81 Da
References
  1. Bookstaff RC, Murphy VA, Skare JA, Minnema D, Sanzgiri U, Parkinson A: Effects of doxylamine succinate on thyroid hormone balance and enzyme induction in mice. Toxicol Appl Pharmacol. 1996 Dec;141(2):584-94. [PubMed:8975784 ]
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Drug created on June 13, 2005 07:24 / Updated on September 29, 2016 02:26