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Identification
NameDoxylamine
Accession NumberDB00366  (APRD00937)
TypeSmall Molecule
GroupsApproved, Vet Approved
Description

Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. [PubChem]

Structure
Thumb
Synonyms
2-(alpha-(2-(Dimethylamino)ethoxy)-alpha-methylbenzyl)pyridine
2-Dimethylaminoethoxyphenylmethyl-2-picoline
Dossilamina
Doxilamina
Doxilminio
Doxylaminum
N,N-Dimethyl-2-(1-phenyl-1-(2-pyridinyl)ethoxy)ethanamine
Phenyl-2-pyridylmethyl-beta-N,N-dimethylaminoethyl ether
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
7 Select Sleep Aidtablet25 mg/1oral7 Eleven2014-08-05Not applicableUs
Care One Sleep Aidtablet25 mg/1oralAmerican Sales Company2004-06-29Not applicableUs
Equaline Sleep Aidtablet25 mg/1oralSupervalu Inc2004-08-10Not applicableUs
Good Neighbor Pharmacy Sleep Aidtablet25 mg/1oralAmerisource Bergen1997-06-26Not applicableUs
Good Sense Sleep Aidtablet25 mg/1oralL. Perrigo Company1997-04-14Not applicableUs
Harris Teeter Sleep Aidtablet25 mg/1oralHarris Teeter, LLC2015-11-21Not applicableUs
Health Mart Sleep Aidtablet25 mg/1oralMc Kesson2011-11-21Not applicableUs
Healthy Accents Sleep Aidtablet25 mg/1oralDZA Brands LLC2011-06-06Not applicableUs
Kirkland Signature Sleep Aidtablet25 mg/1oralCostco Wholesale Company2003-06-27Not applicableUs
Leader Sleep Aidtablet25 mg/1oralCardinal Health1997-10-21Not applicableUs
Nighttime Fast Sleep Aidtablet25 mg/1oralFRED'S, INC.2002-04-112016-02-26Us
Nighttime Sleep Aidtablet25 mg/1oralGREAT LAKES WHOLESALE, MARKETING, & SALES, INC.2002-04-11Not applicableUs
Nighttime Sleep Aidtablet25 mg/1oralKroger Company2014-07-15Not applicableUs
Nighttime Sleep Aidtablet25 mg/1oralBetter Living Brands, Llc2002-04-11Not applicableUs
Nighttime Sleep Aidtablet25 mg/1oralWOONSOCKET PRESCRIPTION CENTER,INCORPORATED2002-04-11Not applicableUs
Nighttime Sleep Aidtablet25 mg/1oralHy Vee Inc2014-12-04Not applicableUs
Nighttime Sleep Aidtablet25 mg/1oralWal Mart Stores Inc2002-04-11Not applicableUs
Nighttime Sleep Aidtablet25 mg/1oralCVS Pharmacy1997-07-23Not applicableUs
Nighttime Sleepaidtablet25 mg/1oralWestern Family Foods Inc1997-11-11Not applicableUs
Sambrosa Sweet Dreams Nighttimesyrup9.75 mg/5mLoralSambrosa Care Inc.2015-07-01Not applicableUs
Sleep Aidtablet25 mg/1oralMeijer Distribution Inc1997-02-21Not applicableUs
Sleep Aidtablet25 mg/1oralHannaford Brothers Company1997-02-07Not applicableUs
Sleep Aidtablet25 mg/1oralKroger Company1997-05-02Not applicableUs
Sleep Aidtablet25 mg/1oralCostco Wholesale Corporation2002-04-11Not applicableUs
Sleep Aidtablet25 mg/1oralSUPERVALU INC.2002-04-11Not applicableUs
Sleep Aidtablet25 mg/1oralH E B1998-05-06Not applicableUs
Sleep Aidtablet25 mg/1oralRite Aid2001-04-11Not applicableUs
Sleep Aidtablet25 mg/1oralHy Vee Inc1998-09-01Not applicableUs
Sleep Aidtablet25 mg/1oralCardinal Health2002-04-11Not applicableUs
Sleep-aidtablet25 mg/1oralH E B2002-04-11Not applicableUs
Smart Sense Sleep Aidtablet25 mg/1oralKmart Corporation2010-12-29Not applicableUs
Sunmark Sleep Aidtablet25 mg/1oralMc Kesson2003-08-15Not applicableUs
Topcare Sleep Aidtablet25 mg/1oralTopco Associates LLC1997-01-29Not applicableUs
Unisom Sleeptabstablet25 mg/1oralChattem, Inc.2016-01-15Not applicableUs
Unisom Sleeptabstablet25 mg/1oralChattem, Inc.1978-10-18Not applicableUs
Unisom-2 Tabletstablet25 mgoralPaladin Labs Inc1987-12-31Not applicableCanada
Wal Som Nighttime Sleep Aidtablet25 mg/1oralWalgreen Company1999-03-05Not applicableUs
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
7 Select Night Time Relief7 Eleven
Acetaminophen Dextromethorphan Hydrobromide and Doxylamine SuccinateJ.P. BUSINESS ENTERPRISE
Acetaminophen, Dextromethorphan Hydrobromide, and Doxylamine SuccinateSpirit Pharmaceuticals, Llc
Acetaminophen,dextromethorphan,doxylamineAgile Pharmachem
Acetaminophen/pseudoephedrine/dextromethorphan/doxylamineApotex Inc
Alka-seltzer Plus Day and Night Cold and Flu FormulaBayer Health Care Llc, Consumer Care
Alka-seltzer Plus Day and Night Multi-symptom Cold and Flu FormulaBayer Health Care Llc, Consumer Care
Alka-seltzer Plus Day and Night Severe Cold and FluBayer Health Care Consumer Care
Alka-seltzer Plus Night Cold and Flu FormulaBayer Health Care Llc, Consumer Care
Alka-seltzer Plus Night Cold Formula (lemon)Bayer Health Care Consumer Care
Alka-seltzer Plus Night Cold MedicineBayer Health Care Llc, Consumer Care
Alka-seltzer Plus Night Severe Cold and FluBayer Health Care Consumer Care
Alka-seltzer Plus Severe Allergy Sinus Congestion and Headache FormulaBayer Health Care Llc, Consumer Care
Alka-seltzer Plus Severe Sinus Congestion and Cough Day and NightBayer Health Care Llc, Consumer Care
Alka-seltzer Plus Severe Sinus Congestion, Allergy and CoughBayer Health Care Llc, Consumer Care
All NiteMajor Pharmaceuticals
All-nite Cold and FluMajor Pharmaceuticals
Allergy and CoughWestern Family Foods Inc
Aurophen Cold Multi SymptomAurohealth LLC
Auroquil Cold and Flu Nighttime ReliefAurohealth LLC
Auroquil Cough Nighttime Cough ReliefAurohealth LLC
Auroquil Severe Cold and Flu Nighttime ReliefAurohealth LLC
Being Well Cold and Flu Relief PMSave A Lot Food Stores Ltd
Being Well Cold Flu Relief PM Multi SymptomSave A Lot Food Stores Ltd
Being Well Night Time Cold and FluSave A Lot Food Stores Ltd
Buckley's Cold & Sinus NightThe Buckley's Company
Buckley's Complete Nighttime SoftgelsThe Buckley's Company
Buckleys Nighttime Cold and SinusThe Buckley's Company
Care One Cold Mutli SymptomAmerican Sales Company
Careone Cold and CoughAmerican Sales Company
Careone Cold MaxAmerican Sales Company
Careone Daytime Nighttime Cold Flu ReliefAmerican Sales Company
Careone Night Time Cold and FluAmerican Sales Company
Careone Nighttime Cold and FluAmerican Sales Company
Careone Nighttime Severe Cold and FluAmerican Sales Company
Careone Nitetime Cold Flu ReliefAmerican Sales Company
Careone Nitetime CoughAmerican Sales Company
Careone Nitetime Severe Cold Flu ReliefAmerican Sales Company
Careone Severe Sinus CongestionAmerican Sales Company
Circle K Nighttime Cold and FluLil' Drug Store Products, Inc
CleartimeHy Vee Inc
Cold & FluVita Health Products Inc
Cold & Flu NighttimeArrow Otc Company
Cold & Flu Relief NighttimeVita Health Products Inc
Cold & Sinus Liquid CapsulesVita Health Products Inc
Cold and CoughH E B
Cold and Cough NighttimeCVS Pharmacy
Cold and Cough Nighttime Cool BlastQUALITY CHOICE (Chain Drug Marketing Association)
Cold and FluWalgreen Company
Cold and Flu Day NightHy Vee Inc
Cold and Flu Daytime NighttimeL&R Distributors, Inc.
Cold and Flu Daytime, Nighttime, Maximum StrengthWALGREEN CO.
Cold and Flu Daytime, Nighttime, Multi-symptomWALGREEN CO.
Cold and Flu Medicine - Night Time FormulaPharmetics (2011) Inc
Cold and Flu Multi-symptom Daytime NighttimeArmy and Air Force Exchange Service
Cold and Flu NighttimeL&R Distributors, Inc.
Cold and Flu Nighttime DWalgreen Company
Cold and Flu Nighttime Multi SymptomL&R Distributors, Inc.
Cold and Flu Nighttime ReliefFreds Inc
Cold and Flu Nighttime/multi-symptomWALGREEN CO.
Cold and Flu ReliefWalgreen Company
Cold and Flu Relief Daytime NighttimeRite Aid Corporation
Cold and Flu Relief Multi SymptomWin Co Foods, Llc
Cold and Flu Relief Multi Symptom NighttimeWin Co Foods, Llc
Cold and Flu Relief Multi-symptomArmy and Air Force Exchange Service
Cold and Flu Relief Multi-symptom, NighttimeArmy and Air Force Exchange Service
Cold and Flu Relief NighttimeAmerisource Bergen (Good Neighbor Pharmacy) 46122
Cold and Flu Relief Nighttime Multi SymptomP And L Development Of New York Corporation (Ready In Case)
Cold and Flu Relief Nighttime, Multi-symptomArmy and Air Force Exchange Service
Cold and Flu Relief Non-drowsy / Daytime Severe / Nighttime SevereWOONSOCKET PRESCRIPTION CENTER,INCORPORATED
Cold and Flu Severe, Nighttime, Maximum StrengthWALGREEN CO.
Cold and Sinus Nighttime ReliefVita Health Products Inc
Cold and Sinus Relief ComboVita Health Products Inc
Cold Flu ReliefPerrigo International
Cold Multi SymptomH E B
Cold Relief Multi Symptom NighttimeCVS Pharmacy
Cold/flu MedicinePerrigo International
Complete Liquid CapsulesVita Health Products Inc
Complete Liquid Capsules Nighttime ReliefVita Health Products Inc
Conrx NighttimeEagle Distributors,Inc.
Contac Cold and Flu Cooling ReliefMeda Consumer Healthcare Inc.
CoughWalgreen Company
Cough and Sore Throat Multi SymptomMeijer Distribution Inc
Cough and Sore Throat NighttimeKinray LLC
Cough and Sore Throat Pain ReliefHy Vee Inc
Cough Day NightHy Vee Inc
Cough Multi SymptomKinray LLC
Cough Nighttime Cough ReliefChain Drug Consortium, LLC
Cough Relief Daytime NighttimeWalgreen Company
Cough Relief NighttimeWalgreen Company
Cvs Nighttime Cold/flu ReliefCVS Pharmacy
DalmacolLaboratoire Riva Inc
Day Night Cold and FluHy Vee Inc
Day Relief Night Relief FreeWestern Family Foods Inc
Day Relief Night Relief Sinus PEWestern Family Foods Inc
Day Time and Night Time Sinus and CongestionWalgreens Company
Day Time Night TimeShopko Stores Operating Co., LLC
Day Time Night Time Cold and FluWalgreens Company
Day Time Night Time Sinus ReliefWalgeens Company
Day Time Nighttime CoughHy Vee Inc
Day-time Night-timeChain Drug Consortium, LLC
Daytime and Nighttime Cold and Flu ReliefChain Drug Consortium, LLC
Daytime and Nighttime Cold and Flu Relief PlusChain Drug Consortium, LLC
Daytime Cough Nighttime CoughCVS Pharmacy
Daytime NighttimeShopko Stores Operating Co., LLC
Daytime Nighttime CleartimeHy Vee Inc
Daytime Nighttime Cold and FluWalgreen Company
Daytime Nighttime Cold and Flu ReliefRite Aid Corporation
Daytime Nighttime Cold and Flu Relief Multi-symptomFamily Dollar (FAMILY WELLNESS)
Daytime Nighttime Cold Flu ReliefSafeway, Inc.
Daytime Nighttime Cold/fluAgile Pharmachem
Daytime Nighttime Multi Symptom Cold and Flu ReliefShopko Stores Operating Co., LLC.
Daytime Nighttime Multi Symptom Cold Flu ReliefCVS Pharmacy
Daytime Nighttime Severe Cold and FluWalgreen Company
Daytime Nighttime Severe Cold and Flu ReliefRite Aid Corporation
Daytime Nighttime Sinus ReliefHy Vee
Daytime Nite TimeKroger Company
Daytime NitetimeKroger Company
Daytime Nitetime Cold and FluKroger Company
Daytime Nitetime Cold and Flu ReliefCare One (American Sales Company)
Daytime Nitetime Cold Flu ReliefCare One (American Sales Company)
Daytime Nitetime SinusMeijer Distribution Inc
Daytime Nitetime Sinus ReliefTOP CARE (Topco Associates LLC)
Daytime PE NitetimePublix Super Markets Inc
Daytime/nighttime Cold and Flu Multi-symptom ReliefL&R Distributors, Inc.
Daytime/nitetime Severe Cold and Flu Maximum StrengthMeijer
Delsym Night Time Multi-symptomReckitt Benckiser LLC
Dg Health Cold and Flu ReliefDolgencorp Inc
Dg Health Cold and Flu Relief Night TimeDolgencorp, LLC
Dg Health Cold and Flu Relief Nite TimeDolgencorp, LLC
Dg Health Cough and Sore Throat Nite TimeDolgencorp, LLC
Dg Health Cough Night TimeDolgencorp, LLC
Dg Health Night Time Cold and Flu ReliefDolgencorp, LLC
Dg Health Pain Relief Cold Night TimeDolgencorp, LLC
DiclectinDuchesnay Inc
DiclegisDuchesnay Usa, Inc.
Equaline Daytime and Nighttime Cold and Flu ReliefSupervalu Inc
Equaline Daytime Nighttime Cold and Flu ReliefSupervalu Inc
Equaline Night Time CoughSupervalu Inc
Equaline NighttimeSupervalu Inc
Equaline Nighttime Cold and Flu ReliefSupervalu Inc
Equaline Nighttime Cough ReliefSupervalu Inc
Equaline Nighttime Severe Cold and FluSupervalu Inc
Equate Daytime NitetimeWal Mart Stores Inc
Equate Daytime Nitetime SevereWal Mart Stores Inc
Equate Nighttime Liquid CapsulesIvax Pharmaceuticals Incorporated
Equate Nite Time Cold Flu ReliefWal Mart Stores Inc
Equate Nite Time CoughWal Mart Stores Inc
Equate NitetimeWal Mart Stores Inc
Equate Nitetime Cold and FluWal Mart Stores Inc
Equate Nitetime DaytimeWal Mart Stores Inc
Equate Nitetime SevereWal Mart Stores Inc
Equate Sinus Night TimeWal Mart Stores Inc
Extra Strength Tylenol Cold and Flu NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Family Care Cold and Flu Multi SymptomUNITED EXCHANGE CORP.
Family Care Cold and Flu NighttimeUNITED EXCHANGE CORP.
Family Care Cough NighttimeUNITED EXCHANGE CORP.
Fulton Street Market Cold and FluAccess Business Group LLC
Fulton Street Market Night Time Cold and FluAccess Business Group LLC
GlentussGlendale Inc
Good Neighbor Pharmacy Cold Multi SymptomAmerisource Bergen
Good Neighbor Pharmacy Cough and Sore ThroatAmerisource Bergen
Good Neighbor Pharmacy Multi SymptomAmerisource Bergen
Good Neighbor Pharmacy Night TimeAmerisource Bergen
Good Neighbor Pharmacy Night Time Cold and FluAmerisource Bergen
Good Neighbor Pharmacy Night Time CoughAmerisource Bergen
Good Neighbor Pharmacy Night Time DAmerisource Bergen
Good Neighbor Pharmacy Night Time SevereAmerisource Bergen
Good Neighbor Pharmacy Severe Night TimeAmerisource Bergen
Good Neighbor Pharmacy Severe Sinus CongestionAmerisource Bergen
Good Sense Cough and Sore Throat Night TimeL Perrigo Company
Good Sense Daytime Night TimeL Perrigo Company
Good Sense Night TimeL Perrigo Company
Good Sense Night Time Cold and FluL. Perrigo Company
Good Sense NighttimeL. Perrigo Company
Good Sense Nighttime CoughL. Perrigo Company
Good Sense Nighttime Daytime Cold and FluL. Perrigo Company
Good Sense Severe NighttimeL Perrigo Company
Good Sense Severe Nighttime Cold and FluL. Perrigo Company
Good Sense Severe Sinus CongestionL. Perrigo Company
Harmon Face Values Night Time ReliefHarmon Stores Inc.
Harris Teeter Daytime NighttimeHarris Teeter, LLC
Harris Teeter NighttimeHarris Teeter, LLC
Harris Teeter Nighttime Cold and FluHarris Teeter, LLC
Health Mart Multi-symptom Cold and Flu Night TimeMc Kesson (Health Mart)
Health Mart Night Time Cold and FluMc Kesson
Healthy Accents Cold and CoughDZA Brands LLC
Healthy Accents Cough and Sore Throat Night TimeDZA Brands LLC
Healthy Accents Day Time Night TimeDZA Brands LLC
Healthy Accents Daytime Nighttime Cold and FluDZA Brands LLC
Healthy Accents Night Time CoughDZA Brands LLC
Healthy Accents Nighttime Cold and FluDZA Brands LLC
Leader Nite TimeCardinal Health
Leader Nite Time Cold Flu Relief Multi SymptomCardinal Health
Leader Nite Time CoughCardinal Health
Leader Nite Time Multi Symptom Cold and Flu ReliefCardinal Health
Leader Nite Time Multi Symptom Cold Flu ReliefCardinal Health
Leader Nite Time Severe Cold and FluCardinal Health
Leader Severe Sinus CongestionCardinal Health
Lortuss DMPoly Pharmaceuticals
Lortuss LqPoly Pharmaceuticals
Major Night Time Multi Symptom Cold and Flu ReliefMajor Pharmaceuticals
Maximum Strength Nighttime Cold/flu ReliefPura Cap Pharmaceutical Llc.
Mckesson Nite TimeMc Kesson
Mercodol With DecaprynAventis Pharma Inc
Mersyndol With CodeineSanofi Aventis Canada Inc
Mucinex Fast-max Day Severe Cold and Night Cold and FluReckitt Benckiser LLC
Mucinex Fast-max Night Time Cold and FluReckitt Benckiser LLC
Mucinex Sinus - Max Day / NightReckitt Benckiser LLC
Multi Symptom Nighttime Cold and Flu ReliefChain Drug Consortium, LLC
Multi Symptom NitetimeCare One (American Sales Company)
Multi-symptom Daytime and Nighttime Cold and Flu Relief PlusWalgreens Company
Multi-symptom Nighttime Sinus ReliefPura Vation Pharmaceuticals Inc
Multi-symptom NitetimeP And L Development Of New York Corporation (Ready In Case)
N - TimeSPIRIT PHARMACEUTICALS,LLC
N - Time SinusSPIRIT PHARMACEUTICALS,LLC
Neocitran Cold & Flu SyrupNovartis Consumer Health Canada Inc.
Next Night Time Cold and Flu ReliefGenomma Lab Usa
Nicold Medicine for AdultsTanta Pharmaceuticals Inc
Night Cold Flu Cough and AllergyHumanwell Pura Cap Pharmaceutical (Wuhan), Ltd.
Night ReliefWestern Family Foods Inc
Night Relief Cold and Flu Liquid CapsulesBanner Pharmacaps (Canada) Ltd.
Night Relief CoughWestern Family Foods Inc
Night Relief FreeWestern Family Foods Inc
Night Relief Multi Symptom Cold and FluWestern Family Foods Inc
Night Relief SinusWestern Family Foods, Inc.
Night TimeShopko Stores Operating Co., LLC
Night Time CherryDollar General
Night Time Cherry Pseudo-freeRite Aid
Night Time Cold and FluSafeway
Night Time Cold and Flu Multi SymptomH E B
Night Time Cold and Flu ReadyincaseP & L Development, LLC
Night Time Cold and Flu ReliefDolgencorp, Inc. (DOLLAR GENERAL & REXALL)
Night Time Cold and Flu Relief Multi SymptomFreds Inc
Night Time Cold and Flue ReliefAllegiant Health
Night Time Cold MaxDolgencorp, LLC
Night Time Cold/flu Relief CherryKareway Product, Inc.
Night Time Cold/flu Relief Multi SymptomShopko Stores Operating Co., LLC.
Night Time Cold/flu Relief OriginalKareway Product, Inc.
Night Time CoughSelect Brand Dist.
Night Time Cough and Sore Throat Cool BlastCVS
Night Time Cough CherryRite Aid
Night Time Cough ReliefH E B
Night Time Day Time Cold and FluHy Vee Inc
Night Time GelcapKareway Product, Inc.
Night Time Liquid Caps Cold Flu Multi SymptomH E B
Night Time Multi Symptom Cold/flu ReliefFreds Inc
Night Time Multi Symptom Flu Cold MedicineSalado Sales, Inc.
Night Time Multi Symptom ReliefPharma Strides Canada Corporation
Night Time Multi-symptom Cold/flu ReliefChain Drug Consortium, LLC
Night Time Original Pseudo-freeRite Aid
Night Time Pseudo-freeRite Aid
Night Time ReliefPharma Strides Canada Corporation
Night Time SinusFreds Inc
Night Time Sinus and CongestionChain Drug Consortium, LLC
Night Time SoftgelsPharma Strides Canada Corporation
Night-time Cherry Multi-symptom Cold/flu ReliefChain Drug Consortium, LLC
Night-time Cough ReliefDiscount Drug Mart
Night-time Multi-symptom Cold/flu CherryDe Moulas Market Basket
Night-time Multi-symptom Cold/flu OriginalDe Moulas Market Basket
Night-time Multi-symptom Cold/flu ReliefDiscount Drug Mart
Night-time Original Multi-symptom Cold/flu ReliefChain Drug Consortium, LLC
Nightcap Cold and Flu Liquid GelsAccucaps Industries Limited
Nightcap Complete Liquid GelsAccucaps Industries Limited
Nightrelief DayreliefWestern Family Foods Inc
Nightrelief Free Multi Symptom Cold FluWestern Family Foods Inc
NighttimeHannaford Brothers Company
Nighttime 325 Liqua CapsJamp Pharma Corporation
Nighttime Cold & Flu Liquid CapsulesVita Health Products Inc
Nighttime Cold & Flu ReliefApotex Inc
Nighttime Cold & Flu Relief SyrupPharmetics (2011) Inc
Nighttime Cold and FluShopko Stores Operating Co., LLC
Nighttime Cold and Flu CherrySelect Brand Dist.
Nighttime Cold and Flu Extra Strength MedicineJamp Pharma Corporation
Nighttime Cold and Flu Lil Drug Store ProductsLil' Drug Store Products, Inc
Nighttime Cold and Flu Liquid CapsulesVita Health Products Inc
Nighttime Cold and Flu Multi SymptomMc Kesson (Health Mart)
Nighttime Cold and Flu OriginalMarc Glassman, Inc.
Nighttime Cold and Flu ReadyincaseAaron Industries Inc.
Nighttime Cold and Flu ReliefWalgreen Company
Nighttime Cold and Flu Relief Multi-symptomFamily Dollar (FAMILY WELLNESS)
Nighttime Cold and Flu Relief PlusChain Drug Consortium,Llc
Nighttime Cold Flu ReliefLIVE BETTER (The Great Atlantic & Pacific Tea Company)
Nighttime Cold MedicineJamp Pharma Corporation
Nighttime Cold Multi-symptom Cool BlastAmerisource Bergen (Good Neighbor Pharmacy) 46122
Nighttime CoughWalgreen Company
Nighttime Cough All Night Cough ReliefAaron Industries Inc.
Nighttime Cough and Sore Throat LiquidJamp Pharma Corporation
Nighttime Cough ReliefRite Aid Corporation
Nighttime Cough. Cold. Flu Gel CapsulesApotex Inc., Private Label Division
Nighttime D Cold and FluHy Vee Inc
Nighttime D Cold and Flu ReliefWalgreen Company
Nighttime Daytime CoughWalgreen Company
Nighttime Liqua CapsJamp Pharma Corporation
Nighttime Multi SymptomCVS Pharmacy
Nighttime Multi Symptom Cold and Flu ReliefFamily Dollar (FAMILY WELLNESS)
Nighttime Multi-symptom Cold and Flu ReliefWALGREEN CO.
Nighttime Multi-symptom Flu ColdSalado Sales, Inc.
Nighttime Relief Severe Cold and FluFRED'S, INC.
Nighttime SevereShopko Stores Operating Co., LLC
Nighttime Severe Cold and FluH E B
Nighttime Severe Cold and Flu ReliefRite Aid Corporation
Nighttime SinusGood Sense (Geiss, Destin & Dunn, Inc.)
Nighttime Sinus Multi SymptomChain Drug Consortium, LLC
Nighttime Sinus ReliefHumanwell Pura Cap Pharmaceutical (Wuhan), Ltd.
Nite TimeKroger Company
Nite Time Cold and FluRite Aid Corporation
Nite Time Cold and Flu ReliefKroger Company
Nite Time Cold MedicineRij Pharmaceutical Corporation
Nite Time Cold Medicine Cherry FlavorRij Pharmaceutical Corporation
Nite Time Cold/flu ReliefOUR FAMILY (Nash Finch Company)
Nite Time Multi Symptom Cold Flu ReliefKroger Company
Nite Time Multi Symptom Cold/fluKroger Company
Nite Time Severe Cold and Flu Damaximum StrengthMeijer
Nite-time Cold and Flu Multi-symptom ReliefPreferred Plus (Kinray)
Nite-time Cold/flu OriginalSalado Sales, Inc.
Nite-timecold/flu Cherry Cold/flu CherrySalado Sales, Inc.
Nitecap Sinus Liquid GelsAccucaps Industries Limited
NitetimeKroger Company
Nitetime Cold and FluKroger Company
Nitetime Cold and Flu ReliefCare One (American Sales Company)
Nitetime Cold Flu ReliefMEIJER, INC.
Nitetime Cold MedicineIvc Industries, Hall Division
Nitetime Cold Medicine LiqJamp Pharma Corporation
Nitetime Cold Medicine Original and CherryWestcan Pharmaceuticals Ltd.
Nitetime Cold Plus Flu ReleifDolgencorp, Inc. (DOLLAR GENERAL & REXALL)
Nitetime Cold/flu, Multi-symptom ReliefWal Mart Stores Inc
Nitetime CoughKroger Company
Nitetime Cough Daytime CoughMeijer Distribution Inc
Nitetime DMeijer Distribution Inc
Nitetime D Multi Symptom Cold Flu ReliefMeijer Distribution Inc
Nitetime DaytimeKroger Company
Nitetime Daytime Cold and FluMeijer Distribution Inc
Nitetime Daytime Severe Cold and FluKroger Company
Nitetime Multi-symptom Cold/flu ReliefGREENBRIER INTERNATIONAL
Nitetime Severe Cold and FluKroger Company
Nitetime Severe Cold and Flu ReliefWestern Family Foods Inc
Nitetime SinusMEIJER, INC.
Nitetime Sinus ReliefTOP CARE (Topco Associates LLC)
Nyquil Cold and FluLil' Drug Store Products, Inc.
Nyquil LiquicapsProcter & Gamble Inc
Nyquil Sinus LiquicapsProcter & Gamble Inc
Original Night-time Multi-symptom Cold/flu ReliefDiscount Drug Mart
P.M. Cold Relief FormulaIvax Pharmaceuticals Incorporated
Poly Hist FortePoly Pharmaceuticals, Inc.
Preferred Plus Severe Nite TimeKinray
Preferred Plus Severe Sinus CongestionKinray
Publix Cherry Flavor NitetimePublix Super Markets Inc
Quality Choice Nighttime Cold and FluQUALITY CHOICE (Chain Drug Marketing Association)
Ratio-calmydoneTeva Canada Limited
Regular Strength Sinus MedicationVita Health Products Inc
Rexall Daytime Nighttime Cold and FluDolgencorp Inc
Rexall Daytime Nighttime Cold FluDolgencorp, LLC
Rexall Night Time Cold and FluDolgencorp Inc
Robitussin Complete NighttimePfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Robitussin Maximum Strength Nighttime Cough DMRichmond Division of Wyeth
Robitussin Peak Cold Nighttime Cold Plus FluRichmond Division of Wyeth
Rx Act Cough and Sore ThroatH E B
Rx Act Nighttime Cold Flu Relief Multi SymptomH E B
Safetussin PMKramer Laboratories
Safeway Nighttime Cold and FluSafeway, Inc.
Sanaflu Night-time Xtreme Multi-symptom Cold/flu Relief Cherry FlavorGrandall Distributing Co., Inc.
Sanatos NightPharmalab Enterprises Inc
Severe Cold and FluWalgreen Company
Severe Cold and Flu Night TimeHy Vee Inc
Severe Cold and Flu NighttimeTarget Corporation
Severe Cold and Flu Nighttime DaytimeHy Vee Inc
Severe Cold and Flu ReliefRite Aid Corporation
Severe Cold and Flu Relief NighttimeRite Aid Corporation
Severe NighttimeCVS Pharmacy
Severe Nighttime Severe DaytimeCVS Pharmacy
Severe Sinus CongestionKroger Company
Shoprite Ni CalmWakefern Food Corporation
Shoprite Ni Calm CoughWakefern Food Corporation
Signature Care Nighttime Severe Cold and Flu ReliefSafeway
Simply Right Night TimeSam's West Inc
Sinus Day/night Extra StrengthPharmetics (2011) Inc
Sinus MedicationVita Health Products Inc
Sinus Medication Day & NightVita Health Products Inc
Sinus Medication Extra Strength Night TimePharmascience Inc
Sinus Medication Night TabletsPharmetics (2011) Inc
Sinus NighttimeCare One (American Sales Company)
Sinus Relief Daytime NighttimeWALGREEN CO.
Smart Sense Daytime Nighttime Cold and FluKmart Corporation
Smart Sense NighttimeKmart Corporation
Smart Sense Nighttime Cold and FluKmart Corporation
Smart Sense Nighttime Cold and Flu Relief Multi SymptomKmart Corporation
Smart Sense Nighttime CoughKmart Corporation
Smart Sense Nighttime DaytimeKmart Corporation
Smart Sense Severe Cold and Flu NighttimeKmart Corporation
Smith Bros Night Time Cough and CongestionUniversal Holdings I Llc
Sound Body Cold and Flu ReliefBig Lots Stores, Inc.
Sunmark Nite TimeMcKesson
Sunmark Nite Time Cold and FluMc Kesson
Sunmark Nite Time CoughMc Kesson
Sunmark Nite Time D Cold and FluMc Kesson
Target Cold/flu ReliefTarget Corporation
Topcare Clear TimeTopco Associates LLC
Topcare Cold and CoughTopco Associates LLC
Topcare Cold MaxTopco Associates LLC
Topcare Cough and Sore ThroatTopco Associates LLC
Topcare Day Time Nite TimeTopco Associates LLC
Topcare Day Time Nite Time Cold and FluTopco Associates LLC
Topcare Day Time Nite Time Cold and Flu ReliefTopco Associates LLC
Topcare Daytime Nighttime Clear TimeTopco Associates LLC
Topcare Nite TimeTopco Associates LLC
Topcare Nite Time Cold and FluTopco Associates LLC
Topcare Nite Time Cold and Flu ReliefTopco Associates LLC
Topcare Nite Time Cold and Flu Relief Multi Symptom ReliefTopco Associates LLC
Topcare Nite Time CoughTopco Associates LLC
Topcare Nite Time DTopco Associates LLC
Topcare Nite Time Day Time Cold and FluTopco Associates LLC
Topcare Nite Time Day Time Cold and Flu ReliefTopco Associates LLC
Topcare Nite Time Multi Symptom ReliefTopco Associates LLC
Topcare Pain Relief Cold NightttimeTopco Associates LLC
Topcare Severe Sinus CongestionTopco Associates LLC
Tussin DM Maximum StrengthCVS Pharmacy
Tylenol Cold & Flu NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Tylenol Cold and Flu NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Tylenol Cold Max NightJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division
Tylenol Cold Multi-symptomJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division
Up and Up Cold and Flu ReliefTarget Corporation
Up and Up Cold and Flu Relief Multi Symptom Day and Night Combo PackTarget Corporation
Up and Up Cold Flu ReliefTarget Corporation
Up and Up Cold Flu Relief Day NightTarget Corporation
Up and Up Cold Flu Relief Multi Symptom NightTarget Corporation
Up and Up Daytime Nighttime Cold and FluTarget Corporation
Up and Up Nighttime Cold and FluTarget Corporation
Up and Up Nighttime Daytime Cold and FluTarget Corporation
Vicks Dayquil and Vicks Nyquil Cold and Flu Multi-symptom Relief/cold and Flu Nighttime ReliefProcter & Gamble Manufacturing Company
Vicks Dayquil and Vicks Nyquil Severe Cold and FluProcter & Gamble Manufacturing Company
Vicks Nyquil Adult Nighttime Colds MedicineProcter & Gamble Inc
Vicks Nyquil Cold & Flu Nighttime ReliefProcter & Gamble Inc
Vicks Nyquil Cold and FluMechanical Servants, Inc.
Vicks Nyquil Cold and Flu Nighttime ReliefThe Procter & Gamble Manufacturing Company
Vicks Nyquil Cold and Flu Nighttime Relief and Vicks Childrens Nyquil Cold and CoughThe Procter & Gamble Manufacturing Company
Vicks Nyquil Complete Cold & FluProcter & Gamble Inc
Vicks Nyquil Complete Cold & Flu CapletsProcter & Gamble Inc
Vicks Nyquil CoughThe Procter & Gamble Manufacturing Company
Vicks Nyquil D Cold and Flu Nighttime ReliefThe Procter & Gamble Manufacturing Company
Vicks Nyquil LiquicapsProcter & Gamble Inc
Vicks Nyquil Liquicaps Cold and Flu Multi-symptom ReliefProcter & Gamble Inc
Vicks Nyquil Severe Cold and FluProcter & Gamble Manufacturing Company
Vicks Nyquil Sinus LiquicapsProcter & Gamble Inc
Vicks Qlearquil Daytime Sinus and Congestion and Nighttime Sinus and CongestionThe Procter & Gamble Manufacturing Company
Vicks Qlearquil Nighttime Sinus and CongestionThe Procter & Gamble Manufacturing Company
Walgreen Nighttime Cold and Flu ReliefWalgreen Company
ZicamMatrixx Initiatives, Inc.
Zicam Multi-symptom Cold & Flu NighttimeZicam Llc
Salts
Name/CASStructureProperties
Doxylamine succinate
ThumbNot applicableDBSALT001402
Categories
UNII95QB77JKPL
CAS number469-21-6
WeightAverage: 270.3694
Monoisotopic: 270.173213336
Chemical FormulaC17H22N2O
InChI KeyInChIKey=HCFDWZZGGLSKEP-UHFFFAOYSA-N
InChI
InChI=1S/C17H22N2O/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16/h4-12H,13-14H2,1-3H3
IUPAC Name
dimethyl({2-[1-phenyl-1-(pyridin-2-yl)ethoxy]ethyl})amine
SMILES
CN(C)CCOC(C)(C1=CC=CC=C1)C1=CC=CC=N1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as benzylethers. These are aromatic ethers with the general formula ROCR' (R = alkyl, aryl; R'=benzene).
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBenzylethers
Direct ParentBenzylethers
Alternative Parents
Substituents
  • Benzylether
  • Pyridine
  • Heteroaromatic compound
  • Tertiary aliphatic amine
  • Tertiary amine
  • Azacycle
  • Organoheterocyclic compound
  • Ether
  • Dialkyl ether
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationUsed alone as a short-term sleep aid, in combination with other drugs as a night-time cold and allergy relief drug. Also used in combination with Vitamin B6 (pyridoxine) to prevent morning sickness in pregnant women.
PharmacodynamicsDoxylamine is an antihistamine commonly used as a sleep aid. This drug is also used to relieve symptoms of hay fever (allergic rhinitis), hives (rash or itching), and other allergic reactions. Doxylamine is a member of the ethanolamine class of antihistamines and has anti-allergy power far superior to virtually every other antihistamine on the market, with the exception of diphenhydramine (Benadryl). It is also the most powerful over-the-counter sedative available in the United States, and more sedating than many prescription hypnotics. In a study, it was found to be superior to even the barbiturate, phenobarbital for use as a sedative. Doxylamine is also a potent anticholinergic.
Mechanism of actionLike other antihistamines, doxylamine acts by competitively inhibiting histamine at H1 receptors. It also has substantial sedative and anticholinergic effects.
Related Articles
AbsorptionReadily absorbed via the gastrointestinal tract.
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Hepatic.

Route of eliminationNot Available
Half life10 hours
ClearanceNot Available
ToxicitySigns of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, swelling of face, lips, tongue, or throat.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9505
Blood Brain Barrier+0.9491
Caco-2 permeable+0.746
P-glycoprotein substrateSubstrate0.7449
P-glycoprotein inhibitor INon-inhibitor0.5123
P-glycoprotein inhibitor IINon-inhibitor0.8383
Renal organic cation transporterInhibitor0.7507
CYP450 2C9 substrateNon-substrate0.8153
CYP450 2D6 substrateNon-substrate0.5432
CYP450 3A4 substrateSubstrate0.6801
CYP450 1A2 substrateNon-inhibitor0.9092
CYP450 2C9 inhibitorNon-inhibitor0.8957
CYP450 2D6 inhibitorInhibitor0.8361
CYP450 2C19 inhibitorNon-inhibitor0.8764
CYP450 3A4 inhibitorNon-inhibitor0.6894
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.736
Ames testNon AMES toxic0.9133
CarcinogenicityNon-carcinogens0.9183
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.9218 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8765
hERG inhibition (predictor II)Inhibitor0.5398
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Kit
Tablet, effervescentoral
Powder, for solutionoral
Kit; capsuleoral
Capsuleoral
Tablet, film coatedoral
Kitoral
Tablet (delayed-release)oral
Tablet, delayed releaseoral
Capsule, gelatin coatedoral
Solutionoral
Tabletoral25 mg/1
Syruporal
Tabletoral
Liquidoral
Capsule, liquid filledoral
Syruporal9.75 mg/5mL
Kit; tabletoral
Tabletoral25 mg
Tablet, coatedoral
Prices
Unit descriptionCostUnit
Doxylamine succinate powder1.5USD g
Unisom sleep aid tablet0.34USD tablet
Sleep aid 25 mg tablet0.15USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6340695 No2001-06-212021-06-21Us
US7560122 No1999-01-252019-01-25Us
Properties
StateLiquid
Experimental Properties
PropertyValueSource
melting point< 25 °CPhysProp
boiling point139 °C at 5.00E-01 mm HgPhysProp
water solubility1 g/ml (succinate salt)Not Available
logP2.5Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.541 mg/mLALOGPS
logP2.9ALOGPS
logP2.96ChemAxon
logS-2.7ALOGPS
pKa (Strongest Basic)8.87ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area25.36 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity82.24 m3·mol-1ChemAxon
Polarizability31.09 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-0040-0956300000-af11cf85a674e7db3735View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-001i-0910000000-b3cb895f045d519f2bf3View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-00kb-5597500000-8495062a84b32e776f33View in MoNA
MSMass Spectrum (Electron Ionization)splash10-0ab9-9200000000-5a71de62862f9881c2a1View in MoNA
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesR06AA09R06AA59
AHFS Codes
  • 04:04.04
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (74 KB)
Interactions
Drug Interactions
Drug
AclidiniumAclidinium may increase the anticholinergic activities of Doxylamine.
AlfentanilDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Alfentanil.
AlprazolamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Alprazolam.
AmitriptylineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
AmobarbitalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Amobarbital.
AmoxapineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Amoxapine.
AmphetamineAmphetamine may decrease the sedative activities of Doxylamine.
AripiprazoleDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Aripiprazole.
AsenapineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Asenapine.
AzelastineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
BaclofenDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Baclofen.
Benzylpenicilloyl PolylysineDoxylamine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
BetahistineThe therapeutic efficacy of Betahistine can be decreased when used in combination with Doxylamine.
Botulinum Toxin Type ADoxylamine may increase the anticholinergic activities of Botulinum Toxin Type A.
Botulinum Toxin Type BDoxylamine may increase the anticholinergic activities of Botulinum Toxin Type B.
BrexpiprazoleDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Brexpiprazole.
BrimonidineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Brimonidine.
BromazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Bromazepam.
BrompheniramineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Brompheniramine.
BuprenorphineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
BuspironeDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Buspirone.
ButabarbitalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Butabarbital.
ButorphanolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Butorphanol.
CarbamazepineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Carbamazepine.
CarbinoxamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Carbinoxamine.
CarisoprodolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Carisoprodol.
CathinoneCathinone may decrease the sedative activities of Doxylamine.
CetirizineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Cetirizine.
ChlordiazepoxideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.
ChlorphenamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.
ChlorpromazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlorpromazine.
ChlorzoxazoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone.
Cimetropium BromideDoxylamine may increase the anticholinergic activities of Cimetropium Bromide.
ClemastineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Clemastine.
ClobazamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Clobazam.
ClomipramineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Clomipramine.
ClonazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Clonazepam.
ClonidineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Clonidine.
ClorazepateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Clorazepate.
ClozapineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Clozapine.
CyclizineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Cyclizine.
CyclobenzaprineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Cyclobenzaprine.
CyproheptadineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine.
DantroleneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dantrolene.
DesfluraneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Desflurane.
DesipramineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
DesloratadineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Desloratadine.
Dexchlorpheniramine maleateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dexchlorpheniramine maleate.
DiazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Diazepam.
DimenhydrinateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dimenhydrinate.
DiphenhydramineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.
DoxepinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.
EfavirenzDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Efavirenz.
EluxadolineDoxylamine may increase the activities of Eluxadoline.
EntacaponeDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Entacapone.
EstazolamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Estazolam.
EszopicloneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Eszopiclone.
EthanolEthanol may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.
EthosuximideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ethosuximide.
EthotoinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ethotoin.
EzogabineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ezogabine.
FelbamateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Felbamate.
FentanylDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.
FexofenadineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.
FlibanserinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Flibanserin.
FlunarizineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Flunarizine.
FlupentixolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Flupentixol.
FluphenazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Fluphenazine.
FlurazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Flurazepam.
FosphenytoinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Fosphenytoin.
GabapentinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Gabapentin.
gabapentin enacarbilDoxylamine may increase the central nervous system depressant (CNS depressant) activities of gabapentin enacarbil.
Glucagon recombinantThe risk or severity of adverse effects can be increased when Doxylamine is combined with Glucagon recombinant.
GuanfacineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Guanfacine.
HaloperidolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Haloperidol.
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Doxylamine.
HydrocodoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
HydromorphoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Hydromorphone.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.
IloperidoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Iloperidone.
ImipramineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Imipramine.
Ipratropium bromideIpratropium bromide may increase the anticholinergic activities of Doxylamine.
IsocarboxazidIsocarboxazid may increase the anticholinergic activities of Doxylamine.
IsofluraneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Isoflurane.
ItoprideThe therapeutic efficacy of Itopride can be decreased when used in combination with Doxylamine.
KetamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ketamine.
LamotrigineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.
LevetiracetamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.
LevocabastineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Levocabastine.
LevocetirizineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Levocetirizine.
LevorphanolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Levorphanol.
LoratadineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Loratadine.
LorazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.
LoxapineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Loxapine.
LurasidoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Lurasidone.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.
MaprotilineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Maprotiline.
MeclizineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Meclizine.
MeprobamateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Meprobamate.
MetaxaloneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Metaxalone.
MethadoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Methadone.
MethocarbamolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Methocarbamol.
MethohexitalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Methohexital.
MethotrimeprazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
MethsuximideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Methsuximide.
MetyrosineDoxylamine may increase the sedative activities of Metyrosine.
MianserinMianserin may increase the anticholinergic activities of Doxylamine.
MidazolamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Midazolam.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.
MirabegronThe risk or severity of adverse effects can be increased when Doxylamine is combined with Mirabegron.
MirtazapineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MoclobemideMoclobemide may increase the anticholinergic activities of Doxylamine.
MorphineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Morphine.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.
NalbuphineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Nalbuphine.
NitrazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Nitrazepam.
Nitrous oxideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.
NortriptylineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Nortriptyline.
OlanzapineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Olanzapine.
OlopatadineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Olopatadine.
OrphenadrineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OxazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Oxazepam.
OxycodoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.
OxymorphoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Oxymorphone.
PaliperidoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Paliperidone.
ParaldehydeDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParoxetineThe risk or severity of adverse effects can be increased when Doxylamine is combined with Paroxetine.
PentazocineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pentazocine.
PentobarbitalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pentobarbital.
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.
PerphenazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Perphenazine.
PethidineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pethidine.
PhenelzinePhenelzine may increase the anticholinergic activities of Doxylamine.
PhenobarbitalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Phenobarbital.
PhenytoinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Phenytoin.
PimozideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pimozide.
PipotiazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pipotiazine.
PizotifenDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pizotifen.
PomalidomideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pomalidomide.
Potassium ChlorideDoxylamine may increase the ulcerogenic activities of Potassium Chloride.
PramipexoleDoxylamine may increase the sedative activities of Pramipexole.
PramlintidePramlintide may increase the anticholinergic activities of Doxylamine.
PregabalinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.
PrimidoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Primidone.
ProchlorperazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Prochlorperazine.
ProcyclidineThe risk or severity of adverse effects can be increased when Procyclidine is combined with Doxylamine.
PromazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Promazine.
PromethazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Promethazine.
PropofolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Propofol.
ProtriptylineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Protriptyline.
QuazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Quazepam.
QuetiapineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Quetiapine.
RamelteonDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.
RamosetronDoxylamine may increase the activities of Ramosetron.
RemifentanilDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Remifentanil.
ReserpineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Reserpine.
RisperidoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Risperidone.
RopiniroleDoxylamine may increase the sedative activities of Ropinirole.
RotigotineDoxylamine may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Doxylamine.
ScopolamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Scopolamine.
Scopolamine butylbromideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Scopolamine butylbromide.
SecobarbitalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Secobarbital.
SecretinThe therapeutic efficacy of Secretin can be decreased when used in combination with Doxylamine.
SevofluraneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Sevoflurane.
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.
StiripentolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Stiripentol.
SufentanilDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Sufentanil.
SulpirideThe therapeutic efficacy of Sulpiride can be decreased when used in combination with Doxylamine.
SuvorexantDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
TacrineThe therapeutic efficacy of Doxylamine can be decreased when used in combination with Tacrine.
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.
TasimelteonDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.
TemazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Temazepam.
TetrabenazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Tetrabenazine.
ThalidomideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThioridazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Thioridazine.
ThiothixeneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Thiothixene.
TiagabineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Tiagabine.
TiotropiumDoxylamine may increase the anticholinergic activities of Tiotropium.
TizanidineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Tizanidine.
TolcaponeDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Tolcapone.
TopiramateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Topiramate.
TramadolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Tramadol.
TranylcypromineTranylcypromine may increase the anticholinergic activities of Doxylamine.
TriazolamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Triazolam.
TrichlormethiazideThe serum concentration of Trichlormethiazide can be increased when it is combined with Doxylamine.
TrifluoperazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Trifluoperazine.
TrimipramineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.
TriprolidineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Triprolidine.
UmeclidiniumUmeclidinium may increase the anticholinergic activities of Doxylamine.
VigabatrinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Vigabatrin.
ZaleplonDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Zaleplon.
ZiconotideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ziconotide.
ZiprasidoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ziprasidone.
ZolpidemDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
ZonisamideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Zonisamide.
ZopicloneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Zopiclone.
ZuclopenthixolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Zuclopenthixol.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Histamine receptor activity
Specific Function:
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Gene Name:
HRH1
Uniprot ID:
P35367
Molecular Weight:
55783.61 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Phosphatidylinositol phospholipase c activity
Specific Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Gene Name:
CHRM1
Uniprot ID:
P11229
Molecular Weight:
51420.375 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Not Available
Gene Name:
CYP2B
Uniprot ID:
Q14097
Molecular Weight:
43147.81 Da
References
  1. Bookstaff RC, Murphy VA, Skare JA, Minnema D, Sanzgiri U, Parkinson A: Effects of doxylamine succinate on thyroid hormone balance and enzyme induction in mice. Toxicol Appl Pharmacol. 1996 Dec;141(2):584-94. [PubMed:8975784 ]
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Drug created on June 13, 2005 07:24 / Updated on May 25, 2016 02:16