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Accession NumberDB01744  (EXPT00827)
TypeSmall Molecule

A bicyclic monoterpene ketone found widely in plants, especially cinnamomum camphora. It is used topically as a skin antipruritic and as an anti-infective agent. [PubChem]

SynonymsNot Available
Prescription ProductsNot Available
Generic Prescription ProductsNot Available
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Vaporizinginhalant62 mg/mLrespiratory (inhalation)Walgreen Co2009-06-01Not AvailableUs
Walgreens Cold Sore Treatmentcream1.3; 30 mg/g; mg/gtopicalWalgreens2013-04-05Not AvailableUs
Walgreens Cold Sore Treatmentcream1.3; 30 mg/g; mg/gtopicalWalgreens2013-07-15Not AvailableUs
Painzaway Balmointment4 g/100gtopicalIndiana Botanic Gardens2001-12-01Not AvailableUs
Neuro Support Plus Foot Balmointment4 g/100gtopicalIndiana Botanic Gardens2014-06-26Not AvailableUs
Rite Aid Cold Sore Treatmentcream1.3; 30 mg/g; mg/gtopicalRite Aid2013-04-05Not AvailableUs
Jointflexcream3.58 g/114gtopicalMOBERG PHARMA NORTH AMERICA LLC2010-04-16Not AvailableUs
Safeway Cold Sore Treatmentcream1.3; 30 mg/g; mg/gtopicalSafeway2013-04-10Not AvailableUs
De La Cruz Camphorointment11 g/100gtopicalDLC Laboratories, Inc.2012-07-26Not AvailableUs
Earths Care Arnica Compoundointment3 g/100gtopicalDLC Laboratories, Inc.2012-02-22Not AvailableUs
Kroger Cold Sore Treatmentcream1.3; 30 mg/g; mg/gtopicalThe Kroger Co.2013-04-30Not AvailableUs
Topcare Cold Sore Treatmentcream1.3; 30 mg/g; mg/gtopicalTopco Associates LLC2013-04-10Not AvailableUs
Shopko Cold Sore Treatmentcream1.3; 30 mg/g; mg/gtopicalShop Ko Stores Operating Co., Llc2013-04-16Not AvailableUs
Vaproizingliquid62 mg/mLrespiratory (inhalation)H E B2010-10-06Not AvailableUs
Equaline Cold Sore Treatmentcream1.3; 30 mg/g; mg/gtopicalSupervalu Inc2013-04-12Not AvailableUs
Vaporizingliquid62 mg/mLrespiratory (inhalation)Meijer Distribution Inc2011-07-22Not AvailableUs
Meijer Cold Sore Treatmentcream1.3; 30 mg/g; mg/gtopicalMeijer2013-04-05Not AvailableUs
Careone Cold Sore Treatmentcream1.3; 30 mg/g; mg/gtopicalAmerican Sales Company2013-04-17Not AvailableUs
Inflammation Otc Bruise Relieflotion32 g/1000gtopicalSkin Deep2011-08-08Not AvailableUs
Vaporizinginhalant62 mg/mLrespiratory (inhalation)Wal Mart Stores, Inc2014-03-07Not AvailableUs
Sierrasil Pain Reliefspray1 mL/30mLtopicalSierra Mountain Minerals Inc. d/b/a Sierra Sil Health Inc.2010-03-01Not AvailableUs
Flex24 Pain Penliquid7.79 g/100mLtopicalLarasan Pharmaceutical Corporation2015-02-10Not AvailableUs
Flex24 Performance Penliquid7.79 g/100mLtopicalLarasan Pharmaceutical Corporation2014-04-08Not AvailableUs
Western Family Pain Relievingcream.04; .1; .3 g/g; g/g; g/gtopicalWestern Family Food, Inc.2013-06-30Not AvailableUs
Western Family Cold Sore Treatmentcream1.3; 30 mg/g; mg/gtopicalWestern Family Foods Inc2013-04-10Not AvailableUs
Healthy Accents Cold Sore Treatmentcream1.3; 30 mg/g; mg/gtopicalDZA Brands LLC2013-04-30Not AvailableUs
O24 Pain Neutralizerspray3.1 g/100mLtopicalO24 Naturals LLC2007-12-03Not AvailableUs
Sierrasil Pain Reliefspray3.1 g/100mLtopicalO24 Naturals, LLC2013-02-01Not AvailableUs
Camphorliquid155 mg/mLrespiratory (inhalation)CVS2009-05-19Not AvailableUs
Apanol Alcanforointment10 g/100gtopicalDelon Laboratories (1990) Ltd2010-11-19Not AvailableUs
Best Choice Cold Sore Treatmentcream1.3; 30 mg/g; mg/gtopicalBest Choice2013-05-02Not AvailableUs
Abridge Cold Sore Treatmentcream1.3; 30 mg/g; mg/gtopicalRanir LLC2013-04-05Not AvailableUs
Joint Formula 88 Max Pluscream3.18 g/100gtopicalSarati International, Inc.2013-08-01Not AvailableUs
Premier Value Cold Sore Treatmentcream1.3; 30 mg/g; mg/gtopicalPremier Value2013-04-16Not AvailableUs
Blue Starointment12.4 mg/gtopicalGHC Group, LLC2012-10-30Not AvailableUs
Tapout Muscle Recovery Rapid Pain Reliefspray1 mL/30mLtopicalRevive Bioscience, Inc.2012-02-01Not AvailableUs
Tapout Muscle Recoverycloth1 mLtopicalRevive Bioscience, Inc.2012-02-01Not AvailableUs
O24 Essential Oil Pain Relievingspray1 mL/30mLtopicalRevive Bioscience, Inc.2012-02-01Not AvailableUs
O24 Essential Oil Pain Relievingcloth1 mLtopicalRevive Bioscience, Inc.2012-02-01Not AvailableUs
Maxrelief Arnicacream30 mg/1000mgtopicalNatures Investment Holdings Pty Ltd dba Maxrelief USA2014-06-01Not AvailableUs
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
CategoriesNot Available
CAS number76-22-2
WeightAverage: 152.2334
Monoisotopic: 152.120115134
Chemical FormulaC10H16O
DescriptionThis compound belongs to the class of organic compounds known as bicyclic monoterpenoids. These are monoterpenoids containing exactly 2 rings, which are fused to each other.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassPrenol lipids
Sub ClassMonoterpenoids
Direct ParentBicyclic monoterpenoids
Alternative Parents
  • Bicyclic monoterpenoid
  • Bornane monoterpenoid
  • Cyclohexanone
  • Ketone
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Aliphatic homopolycyclic compound
Molecular FrameworkAliphatic homopolycyclic compounds
External Descriptors
IndicationNot Available
PharmacodynamicsNot Available
Mechanism of actionNot Available
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Predicted ADMET features
Human Intestinal Absorption+0.9971
Blood Brain Barrier+0.9836
Caco-2 permeable+0.8084
P-glycoprotein substrateNon-substrate0.5868
P-glycoprotein inhibitor INon-inhibitor0.639
P-glycoprotein inhibitor IINon-inhibitor0.9104
Renal organic cation transporterNon-inhibitor0.8103
CYP450 2C9 substrateNon-substrate0.823
CYP450 2D6 substrateNon-substrate0.8379
CYP450 3A4 substrateSubstrate0.6692
CYP450 1A2 substrateNon-inhibitor0.8876
CYP450 2C9 substrateNon-inhibitor0.9088
CYP450 2D6 substrateNon-inhibitor0.9696
CYP450 2C19 substrateNon-inhibitor0.9313
CYP450 3A4 substrateNon-inhibitor0.9583
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.978
Ames testNon AMES toxic0.9133
BiodegradationNot ready biodegradable0.6872
Rat acute toxicity1.6328 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.913
hERG inhibition (predictor II)Non-inhibitor0.8076
ManufacturersNot Available
Dosage forms
Clothtopical1 mL
Creamtopical.04; .1; .3 g/g; g/g; g/g
Creamtopical1.3; 30 mg/g; mg/g
Creamtopical3.18 g/100g
Creamtopical3.58 g/114g
Creamtopical30 mg/1000mg
Inhalantrespiratory (inhalation)62 mg/mL
Liquidrespiratory (inhalation)155 mg/mL
Liquidrespiratory (inhalation)62 mg/mL
Liquidtopical7.79 g/100mL
Lotiontopical32 g/1000g
Ointmenttopical10 g/100g
Ointmenttopical11 g/100g
Ointmenttopical12.4 mg/g
Ointmenttopical3 g/100g
Ointmenttopical4 g/100g
Spraytopical1 mL/30mL
Spraytopical3.1 g/100mL
PricesNot Available
PatentsNot Available
Experimental Properties
melting point180 °CPhysProp
boiling point204 °CPhysProp
water solubility1600 mg/L (at 25 °C)YALKOWSKY,SH & HE,Y (2003)
logP2.38DAYLIGHT (1999)
Predicted Properties
Water Solubility0.88 mg/mLALOGPS
pKa (Strongest Basic)-7.5ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area17.07 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity44.49 m3·mol-1ChemAxon
Polarizability17.73 Å3ChemAxon
Number of Rings2ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Mass Spec (NIST)Not Available
SpectraNot Available
Synthesis Reference

Gerard Lang, Serge Forestier, Alain LaGrange, “Derivatives of 3-benzylidene camphor, process for their preparation and their use as protective agents against UV rays and as medicaments.” U.S. Patent US4710584, issued January, 1984.

General ReferenceNot Available
External Links
ATC CodesNot Available
AHFS CodesNot Available
PDB Entries
FDA labelNot Available
MSDSNot Available
Drug InteractionsNot Available
Food InteractionsNot Available


1. Camphor 5-monooxygenase

Kind: protein

Organism: Pseudomonas putida

Pharmacological action: unknown


Name UniProt ID Details
Camphor 5-monooxygenase P00183 Details


  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

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Drug created on June 13, 2005 07:24 / Updated on September 16, 2013 17:15