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Identification
Name Penicillin V
Accession Number DB00417 (APRD00423, DB08415)
Type small molecule
Groups approved
Description

Penicillin V is narrow spectrum antibiotic used to treat mild to moderate infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered orally. Penicillin V may also be used in some cases as prophylaxis against susceptible organisms.

Natural penicillins are considered the drugs of choice for several infections caused by susceptible gram positive aerobic organisms, such as Streptococcus pneumoniae, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. Aminoglycosides may be added for synergy against group B streptococcus (S. agalactiae), S. viridans, and Enterococcus faecalis. The natural penicillins may also be used as first or second line agents against susceptible gram positive aerobic bacilli such as Bacillus anthracis, Corynebacterium diphtheriae, and Erysipelothrix rhusiopathiae. Natural penicillins have limited activity against gram negative organisms; however, they may be used in some cases to treat infections caused by Neisseria meningitidis and Pasteurella. They are not generally used to treat anaerobic infections. Resistance patterns, susceptibility and treatment guidelines vary across regions.
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Synonyms
  • Fenossimetilpenicillina [Dcit]
  • Fenoximetilpenicilina [INN-Spanish]
  • Penicillin Phenoxymethyl
  • Penicillin V Potassium
  • Phenoximethylpenicillinum
  • Phenoxymethyl Penicillin
  • Phenoxymethylenepenicillinic Acid
  • Phenoxymethylpenicillin Potassium
  • Phenoxymethylpenicillinic Acid
  • Phenoxymethylpenicillinic Acid Potassium Salt
Brand names
  • Acipen V
  • Apopen
  • Beepen-Vk
  • Beromycin
  • Betapen-Vk
  • Calcipen
  • Compocillin V
  • Crystapen V
  • Distaquaine V
  • Eskacillian V
  • Eskacillin V
  • Fenacilin
  • Fenospen
  • Fenoxypen
  • Ledercillin Vk
  • Meropenin
  • Oracillin
  • Oratren
  • Ospen
  • Pen-Oral
  • Pen-V
  • Pen-Vee
  • Pen-Vee K
  • Penapar-Vk
  • Penicillin Vk
  • Penicillin-Vk
  • Pfizerpen Vk
  • Phenocillin
  • Phenomycilline
  • Phenopenicillin
  • Robicillin
  • Rocilin
  • Stabicillin
  • Uticillin Vk
  • V-Cil
  • V-Cillin
  • V-Cillin K
  • V-Cylina
  • V-Cyline
  • V-Tablopen
  • Vebecillin
  • Veetids
  • Veetids '125'
  • Veetids '250'
  • Veetids '500'
Brand name mixtures
  • Albacillin Suspension (Novobiocin (Novobiocin Sodium) + Penicillin G Procaine)
  • Anprofac 500 (Chlortetracycline Hydrochloride + Penicillin (Penicillin G Procaine) + Sulfamethazine)
  • Aureo Mix 625 G Granular Medicated Premix (Chlortetracycline + Penicillin (Penicillin G Procaine) + Sulfamethazine)
  • Aureo S-P 250g Premix (Chlortetracycline + Penicillin (Penicillin G Procaine) + Sulfamethazine)
  • Aureo Sp 250g Premix (Chlortetracycline + Penicillin (Penicillin G Procaine) + Sulfamethazine)
  • Aureo Sp250-G Medicated Premix (Chlortetracycline Hydrochloride + Penicillin G Procaine + Sulfamethazine)
  • Aureomix 500g Granular Med-Premix (Chlortetracycline + Penicillin (Penicillin G Procaine) + Sulfamethazine)
  • Aureomix 625g Premix (Chlortetracycline + Penicillin (Penicillin G Procaine) + Sulfamethazine)
  • Aurex Rotenone Drops (Bacitracin + Penicillin + Rotenone + Streptomycin (Streptomycin Sulfate) + Undecylenic Acid)
  • Banana Boat Sooth-a-Caine W.Moist.Aloe V.Gel (Lidocaine + Menthol)
  • Benzapro Liq (Penicillin G Benzathine + Penicillin G Procaine)
  • Bicillin a-P Injection Pws (Penicillin G Benzathine + Penicillin G Potassium + Penicillin G Procaine)
  • Big Country Medicated T.V. Special (Calcium D-Pantothenate + Nicotinamide + Oxytetracycline (Oxytetracycline Hydrochloride) + Vitamin a (Retinol) + Vitamin B12 + Vitamin B2 + Vitamin D3)
  • Big V Baby Sunblock Spf 30 Lot (Homosalate + Octinoxate + Octisalate + Oxybenzone)
  • Big V Kids Sunblock Lotion Spf 30 (Octinoxate + Octisalate + Octocrylene + Oxybenzone)
  • Big V Sunblock Lotion 30 Spf (Homosalate + Octinoxate + Octisalate + Oxybenzone)
  • Big V Sunblock Lotion Spf 15 (Octinoxate + Oxybenzone)
  • C.H.V. Formula (Calcium (Calcium Carbonate, Calcium Citrate) + Magnesium (Magnesium Oxide, Magnesium Citrate) + Manganese (Manganese Citrate) + Vitamin C + Vitamin D3 + Vitamin E (D-Alpha Tocopheryl Acid Succinate))
  • C.V. Formula (Ubidecarenone + Vitamin E (D-Alpha Tocopherol))
  • C.V.S. Formula Tab (Beta-Carotene + Biotin + Calcium (Calcium Ascorbate, Calcium Citrate) + Choline (Choline Citrate, Choline Bitartrate) + Chromium (Chromium Proteinate) + D-Alpha Tocopheryl Acid Succinate + D-Pantothenic Acid (Calcium D-Pantothenate) + Dl-Methionine + Folic Acid + Inositol + Iodine (Kelp) + Magnesium (Magnesium Proteinate) + Manganese (Manganese Proteinate) + Molybdenum (Molybdenum Proteinate) + Nicotinamide + Nicotinic Acid + Potassium (Potassium Proteinate) + Selenium (Selenium Proteinate) + Thiamine Hydrochloride + Ubidecarenone + Vitamin a Palmitate + Vitamin B12 + Vitamin B2 + Vitamin B6 (Pyridoxine Hydrochloride, Pyridoxal-5-Phosphate) + Vitamin C + Zinc (Zinc Proteinate))
  • Cal-P-I-D (Calcium Phosphate (Dibasic) + Charcoal Activated + Ethylenediamine Dihydroiodide + Vitamin D3)
  • Chlor 250 Premix (Chlortetracycline + Penicillin G (Penicillin G Procaine) + Sulfamethazine)
  • Chlorosol 250 Premix (Chlortetracycline Hydrochloride + Penicillin G Procaine + Sulfamethazine)
  • Chlorosol-250 (Chlortetracycline Hydrochloride + Penicillin G (Penicillin G Procaine) + Sulfamethazine)
  • Combiotic Vitamin Booster Pws (Calcium D-Pantothenate + Menadione + Nicotinic Acid + Penicillin G Potassium + Pyridoxine Hydrochloride + Streptomycin (Streptomycin Sulfate) + Vitamin a + Vitamin B12 + Vitamin B2 + Vitamin D3 + Vitamin E)
  • Combisec Dry Cow (Dihydrostreptomycin (Dihydrostreptomycin Sulfate) + Penicillin G Procaine)
  • Derapen Inj (Penicillin G Benzathine + Penicillin G Procaine)
  • Diathesis V-2 (Barium Carbonate + Cobalt + Ginkgo Biloba + Nickel + Pancreas + Phosphoric Acid + Phosphorus + Zinc)
  • Diathesis V-I (Copper + Ginkgo Biloba + Pancreas + Zinc)
  • Dp Booster Pws (D-Pantothenic Acid (Calcium D-Pantothenate) + Menadione + Nicotinic Acid + Penicillin G Potassium + Pyridoxine Hydrochloride + Streptomycin (Streptomycin Sulfate) + Vitamin a + Vitamin B1 + Vitamin B12 + Vitamin B2 + Vitamin D3 + Vitamin E)
  • Dual Mix (Potassium (Potassium Citrate) + Vitamin C (Calcium Ascorbate))
  • Duplocillin La Sus Inj (Penicillin G Benzathine + Penicillin G Procaine)
  • E.V.C. Vitamin & Mineral Supplement (Pyridoxine Hydrochloride + Vitamin a Palmitate + Vitamin C + Zinc (Zinc Gluconate))
  • E.V.C. Vitamins Tab (Vitamin a (Vitamin a Palmitate) + Vitamin B6 + Vitamin C + Zinc (Zinc Gluconate))
  • Ego Life (Chlorine (Sodium Chloride) + Chromium (Chromium Hvp Chelate) + D-Pantothenic Acid (Calcium D-Pantothenate) + Magnesium (Magnesium Chloride) + Phosphorus (Potassium Phosphate Monobasic) + Sodium (Sodium Chloride) + Vitamin B2)
  • Ephedrine V with Guaifenesin (Ephedrine Hydrochloride + Guaifenesin)
  • Eye and Wound Powder (Chlorhexidine Hydrochloride + Hydrocortisone Acetate + Penicillin G Procaine + Sulfathiazole)
  • F'n P (Calcium (Calcium Carbonate) + Chromium (Chromium Hvp Chelate) + Copper (Copper Sulfate) + Magnesium (Magnesium Oxide) + Manganese (Manganese Sulfate) + Vitamin a + Vitamin C + Vitamin D3)
  • Fem (Chromium (Chromium Hvp Chelate) + Nicotinamide + Potassium (Potassium Citrate) + Vitamin C + Vitamin E (Dl-Alpha Tocopheryl Acetate))
  • Formula F.V 213 Liq (Boldo + Celandine + Cinchona Officinalis + Citrullus Colocynthis + Cynara Scolymus + Goldenrod + Hydrastis Canadensis + Lycopodium + Milk Thistle + Taraxacum Officinale Weber)
  • Formula R.V. 219 Dps (Barberry Root + Cantharides + Capsicum + Citrullus Colocynthis + Formica Rufa + Goldenrod + Juniper Berries + Sarsaparilla + Taraxacum Officinale Weber + Uva Ursi)
  • Formula V S C Tab (Beta-Carotene + Biotin + Choline Bitartrate + Chromium (Chromium Proteinate) + D-Alpha Tocopheryl Acid Succinate + Dl-Methionine + Folic Acid + Inositol + Magnesium (Magnesium Oxide) + Manganese (Manganese Gluconate) + Nicotinamide + Nicotinic Acid + Potassium (Potassium Citrate) + Pyridoxine Hydrochloride + Selenium (Selenium Proteinate) + Thiamine Hydrochloride + Vitamin a Palmitate + Vitamin B12 + Vitamin B2 + Vitamin C + Vitamin C (Calcium Ascorbate) + Zinc (Zinc Gluconate))
  • Formula V.H. 222 Liq (Aesculus Hippocastanum + Arnica + Collinsonia Canadensis + Ginkgo Biloba + Hamamelis Virginiana + Hydrastis Canadensis + Hydrogen Fluoride + Paeonia Officinalis + Pulsatilla + Sepia Officinalis L)
  • Formula V.I.R. Tab (Dl-Methionine + Vitamin a (Fish Liver Oil) + Vitamin C)
  • Forte Topical Suspension (Hydrocortisone Acetate + Hydrocortisone Sodium Succinate + Neomycin (Neomycin Sulfate) + Penicillin G Procaine + Polymyxin B Sulfate)
  • Guaiacol Plus Pwr (Ammonium Chloride + Guaifenesin + Potassium Iodide)
  • Homo (Calcium (Calcium Phosphate (Tribasic)) + Chromium (Chromium Hvp Chelate) + Phosphorus (Calcium Phosphate (Tribasic), Potassium Phosphate Monobasic) + Vitamin C + Vitamin E (Dl-Alpha Tocopheryl Acetate) + Zinc (Zinc Gluconate))
  • Isocare M.V.R. (Alkyl Dimethyl Ethylbenzyl Ammonium Chloride + Benzalkonium Chloride)
  • Kenyan (Biotin + Choline Bitartrate + Chromium (Chromium Hvp Chelate) + Copper (Copper Gluconate) + D-Pantothenic Acid (Calcium D-Pantothenate) + Nicotinamide + Vitamin B1 + Vitamin B12 + Vitamin B2 + Vitamin B6 + Vitamin C + Vitamin E (Dl-Alpha Tocopheryl Acetate) + Zinc (Zinc Gluconate))
  • Lactated Ringer's Injection Usp (Calcium Chloride + Potassium Chloride + Sodium Chloride + Sodium Lactate)
  • Lemon Fresh V - Liq Hom Hos (Benzalkonium Chloride + Didecyl Dimethyl Ammonium Chloride)
  • Lidocaine Hcl 2% Epinephrine Inj (Epinephrine + Lidocaine Hydrochloride)
  • Longisil (Penicillin G Benzathine + Penicillin G Procaine)
  • Lutropin-V (Porcine Pituitary Luteinizing Hormone for Injection) (Porcine Pituitary Luteinizing Hormone + Sodium Chloride)
  • M.V.I. 12 (Biotin + D-Pantothenic Acid (Panthenol) + Folic Acid + Nicotinamide + Pyridoxine Hydrochloride + Vitamin a + Vitamin B1 (Thiamine Hydrochloride) + Vitamin B12 + Vitamin B2 (Riboflavin 5'-Phosphate Sodium) + Vitamin C + Vitamin D + Vitamin E (Dl-Alpha Tocopheryl Acetate))
  • M.V.I. Paediatric (Biotin + D-Pantothenic Acid + Folic Acid + Nicotinamide + Pyridoxine Hydrochloride + Vitamin a + Vitamin B1 (Thiamine Hydrochloride) + Vitamin B12 + Vitamin B2 (Riboflavin 5'-Phosphate Sodium) + Vitamin C + Vitamin D + Vitamin E + Vitamin K1)
  • Magnus (Chromium (Chromium Hvp Chelate) + Copper (Copper Gluconate) + D-Pantothenic Acid (Calcium D-Pantothenate) + Folic Acid + Nicotinamide + Vitamin B1 + Vitamin B12 + Vitamin B2 + Vitamin B6 + Vitamin C + Vitamin E (D-Alpha Tocopheryl Acetate) + Zinc (Zinc Gluconate))
  • Malteada Oml (Biotin + Calcium (Calcium Phosphate (Tribasic)) + Chloride (Potassium Chloride) + Chromium (Chromium Hvp Chelate) + Copper (Copper Sulfate) + D-Pantothenic Acid (Calcium D-Pantothenate) + Folic Acid + Iodine (Potassium Iodide) + Iron (Ferrous Fumarate) + Magnesium (Magnesium Oxide) + Manganese (Manganese Sulfate) + Molybdenum (Sodium Molybdate) + Nicotinamide + Phosphorus (Potassium Phosphate, Calcium Phosphate (Tribasic)) + Potassium (Potassium Chloride) + Selenium (Sodium Selenite) + Vitamin a (Vitamin a Palmitate) + Vitamin B1 + Vitamin B12 + Vitamin B2 + Vitamin B6 + Vitamin C + Vitamin D3 + Vitamin E (Dl-Alpha Tocopheryl Acetate) + Zinc (Zinc Oxide))
  • Malteada Oml Vanilla (Biotin + Calcium (Calcium Phosphate (Dibasic)) + Chloride (Potassium Chloride) + Chromium (Chromium Hvp Chelate) + Copper (Copper Sulfate) + D-Pantothenic Acid (Calcium D-Pantothenate) + Folic Acid + Iodine (Potassium Iodide) + Iron (Ferrous Fumarate) + Magnesium (Magnesium Oxide) + Manganese (Manganese Sulfate) + Molybdenum (Sodium Molybdate) + Nicotinamide + Phosphorus (Potassium Phosphate Monobasic, Calcium Phosphate (Dibasic)) + Potassium (Potassium Chloride) + Selenium (Sodium Selenite) + Vitamin a (Vitamin a Palmitate) + Vitamin B1 + Vitamin B12 + Vitamin B2 + Vitamin B6 + Vitamin D3 + Vitamin E (Dl-Alpha Tocopheryl Acetate) + Zinc (Zinc Oxide))
  • Mastitis Care (Neomycin (Neomycin Sulfate) + Penicillin G Potassium + Polymyxin B (Polymyxin B Sulfate) + Streptomycin (Streptomycin Sulfate))
  • Medic Aid 2-50 (Menadione Sodium Bisulfite + Penicillin (Penicillin G Potassium) + Penicillin (Penicillin G Procaine) + Streptomycin Sulfate + Vitamin a + Vitamin D3)
  • Medivit (Calcium D-Pantothenate + Menadione + Nicotinamide + Penicillin G Potassium + Pyridoxine Hydrochloride + Streptomycin Sulfate + Vitamin a + Vitamin B1 + Vitamin B12 + Vitamin B2 + Vitamin D3 + Vitamin E)
  • Mega V&M (Biotin + Calcium (Calcium Hvp Chelate) + Choline Bitartrate + Chromium (Yeast) + Copper (Copper Hvp Chelate) + D-Pantothenic Acid (Calcium D-Pantothenate) + Folic Acid + Inositol + Iodine (Kelp) + Iron (Iron Hvp Chelate) + Magnesium (Magnesium Hvp Chelate) + Manganese (Manganese Hvp Chelate) + Nicotinamide + Potassium (Potassium Gluconate) + Selenium (Yeast) + Vitamin a (Fish Liver Oil) + Vitamin B1 (Thiamine Hydrochloride) + Vitamin B12 (Vitamin B12) + Vitamin B2 + Vitamin B6 (Pyridoxine Hydrochloride) + Vitamin C + Vitamin D (Fish Liver Oil) + Vitamin E (D-Alpha Tocopheryl Acetate) + Zinc (Zinc Gluconate))
  • Mineralytes Sol (Calcium Chloride + Dextrose + Magnesium Chloride + Potassium Acetate + Sodium Acetate + Sodium Chloride)
  • Mineralytes Sol in (Calcium Chloride + Dextrose + Magnesium Chloride + Potassium Acetate + Sodium Acetate + Sodium Chloride + Sodium Citrate)
  • Multi V+M Ctr Tab (Biotin + Calcium (Calcium Phosphate (Dibasic)) + Choline Bitartrate + Chromium + Copper (Copper Sulfate) + D-Alpha Tocopherol + D-Pantothenic Acid (Calcium D-Pantothenate) + Folic Acid + Inositol + Iodine (Potassium Iodide) + Iron (Ferrous Fumarate) + Magnesium (Magnesium Oxide) + Manganese (Manganese Sulfate) + Nicotinamide + Phosphorus (Calcium Phosphate (Dibasic)) + Potassium (Potassium Chloride) + Pyridoxine Hydrochloride + Selenium + Thiamine Hydrochloride + Vitamin a + Vitamin B12 + Vitamin B2 + Vitamin C + Vitamin D + Zinc (Zinc Oxide))
  • Multi Wormer for Cats (Dichlorophene + Piperazine (Piperazine Citrate))
  • Multi Wormer for Dogs (Dichlorophene + Piperazine (Piperazine Citrate))
  • N.L.I.V. Tab (Copper + Manganese Chloride)
  • N.V.A.G. Tab (Copper + Silicon Dioxide + Silver)
  • Neo P.P.G. (Neomycin (Neomycin Sulfate) + Penicillin G Potassium)
  • Neospan Mastitis Treatment (Neomycin (Neomycin Sulfate) + Penicillin G Potassium + Polymyxin B (Polymyxin B Sulfate) + Streptomycin (Streptomycin Sulfate))
  • Novodry Plus Suspension (Novobiocin (Novobiocin Sodium) + Penicillin G Procaine)
  • Nutrol V Capsule (Beta-Carotene + D-Alpha Tocopheryl Acetate + Selenium (Yeast) + Vitamin C)
  • Oml (Biotin + Calcium (Calcium Chloride) + Chromium (Chromium Hvp Chelate) + Copper (Copper Gluconate) + D-Pantothenic Acid (Calcium D-Pantothenate) + Magnesium (Magnesium Chloride) + Manganese (Manganese Gluconate) + Nicotinamide + Potassium (Potassium Citrate) + Selenium (Sodium Selenite) + Vitamin a (Vitamin a Palmitate, Beta-Carotene) + Vitamin B1 + Vitamin B12 + Vitamin B2 + Vitamin B6 + Vitamin C + Vitamin D3 + Vitamin E (Dl-Alpha Tocopheryl Acetate) + Zinc (Zinc Gluconate))
  • Omnilife P.M. (Chromium (Chromium Hvp Chelate) + Copper (Copper Gluconate) + D-Pantothenic Acid (Calcium D-Pantothenate) + Vitamin a + Vitamin C + Vitamin E (Dl-Alpha Tocopheryl Acetate) + Zinc (Zinc Gluconate))
  • Oralytes Pck-Pws (Citric Acid + Dextrose + Glycine + Potassium Chloride + Potassium Phosphate Dibasic + Sodium Acetate + Sodium Chloride)
  • Oralytes-He - Pwr (Citric Acid + Dextrose + Glycine + Potassium Chloride + Potassium Phosphate Dibasic + Sodium Acetate + Sodium Chloride)
  • P Onytricin P (Calcium D-Pantothenate + Menadione Sodium Bisulfite + Nicotinamide + Tetracycline Hydrochloride + Vitamin a + Vitamin B12 + Vitamin B2 + Vitamin B6 + Vitamin D3 + Vitamin E)
  • P.G. 600inj. (Chorionic Gonadotropin + Gonadotrophin Serum (Pmsg))
  • Pancrease-V Powder (Amylase + Lipase + Protease)
  • Parvit Plus (Penicillin G Procaine + Streptomycin Sulfate + Vitamin a + Vitamin C + Vitamin D3 + Vitamin E + Vitamin K1)
  • Pedikleen (Benzalkonium Chloride + Didecyl Dimethyl Ammonium Chloride + Dioctyl Dimethyl Ammonium Chloride + Octyl Decyl Dimethyl Ammonium Chloride)
  • Pen-Bgp La Inj (Penicillin G Benzathine + Penicillin G Procaine)
  • Pendamine (Chlorpheniramine Maleate + Dexamethasone + Dihydrostreptomycin Sulfate + Penicillin G Procaine)
  • Pendure a Inj (Penicillin G Benzathine + Penicillin G Procaine + Vitamin a)
  • Pendure Neat (Penicillin G Benzathine + Penicillin G Procaine)
  • Pendure S (Dihydrostreptomycin Sulfate + Penicillin G Benzathine + Penicillin G Procaine)
  • Penlong Xl (Penicillin G Benzathine + Penicillin G Procaine)
  • Physioneal 40 Glucose 1.36% W/V 13.6mg/Ml Solution for Peritoneal Dialysis (Calcium Chloride + Dextrose + Magnesium Chloride + Sodium Bicarbonate + Sodium Chloride + Sodium Lactate)
  • Physioneal 40 Glucose 2.27% W/V 22.7 Mg/Ml, Solution for Peritoneal Dialysis (Calcium Chloride + Dextrose + Magnesium Chloride + Sodium Bicarbonate + Sodium Chloride + Sodium Lactate)
  • Physioneal 40 Glucose 3.86% W/V 38.6mg/Ml, Solution for Peritoneal Dialysis (Calcium Chloride + Dextrose + Magnesium Chloride + Sodium Bicarbonate + Sodium Chloride + Sodium Lactate)
  • Pmsg 6000 (Pregnant Mare's Serum Gonadotrophin for Injection) (Gonadotrophin Serum (Pmsg) + Water)
  • Pmsg-5000 - Pws-Liq (Diluent) Im Iv Sc (Gonadotrophin Serum (Pmsg) + Water)
  • Poly Tonine a D Inj (Vitamin a + Vitamin D3)
  • Poly Tonine a Super Booster No.1 (Calcium D-Pantothenate + Menadione + Nicotinamide + Penicillin G Potassium + Pyridoxine Hydrochloride + Streptomycin Sulfate + Vitamin a + Vitamin B12 + Vitamin B2 + Vitamin D3 + Vitamin E (Dl-Alpha Tocopheryl Acetate))
  • Poly Tonine Formule 500-S (Biotin + Calcium D-Pantothenate + Calcium Phosphate (Dibasic) + Choline Chloride + Copper Sulfate + Dl-Methionine + Ferrous Sulfate + Folic Acid + Manganese Oxide + Menadione + Nicotinic Acid + Potassium Iodide + Pyridoxine Hydrochloride + Sodium Selenite + Thiamine Mononitrate + Vitamin a + Vitamin B12 + Vitamin B2 + Vitamin D3 + Vitamin E)
  • Poly Vita Pen Strep (Calcium D-Pantothenate + Menadione Sodium Bisulfite + Nicotinic Acid + Penicillin G Procaine + Streptomycin (Streptomycin Sulfate) + Vitamin a + Vitamin B12 + Vitamin B2 + Vitamin D3 + Vitamin E)
  • Polytonine a Super Booster No 1 Pws (Calcium D-Pantothenate + Menadione + Nicotinamide + Penicillin G Potassium + Pyridoxine Hydrochloride + Streptomycin (Streptomycin Sulfate) + Vitamin a + Vitamin B12 + Vitamin B2 + Vitamin D3 + Vitamin E (Dl-Alpha Tocopheryl Acetate))
  • Poultry Rx Pwr (Calcium D-Pantothenate + Folic Acid + Menadione Sodium Bisulfite + Nicotinic Acid + Penicillin G Potassium + Streptomycin (Streptomycin Sulfate) + Vitamin a + Vitamin B1 + Vitamin B12 + Vitamin B2 + Vitamin B6 + Vitamin D3 + Vitamin E)
  • Premelange 25/2 Vit Porcs Medic (Asp-250) (Chlortetracycline Hydrochloride + Penicillin G + Sulfamethazine + Vitamin a + Vitamin D)
  • Pro En Vimi Aureo-Sulfa-Vit (Chlortetracycline Hydrochloride + Sulfamethazine + Vitamin a + Vitamin D3 + Vitamin E)
  • Solu-I.V. Chg-Alcohol (Chlorhexidine Gluconate + Isopropyl Alcohol)
  • Solu-I.V. Tiges Montees Chd Alcool - Stk (Chlorhexidine Gluconate + Isopropyl Alcohol)
  • Special Formula 17900-Forte Suspension (Dihydrostreptomycin (Dihydrostreptomycin Sulfate) + Hydrocortisone Acetate + Hydrocortisone Sodium Succinate + Novobiocin (Novobiocin Sodium) + Penicillin G Procaine + Polymyxin B Sulfate)
  • Starbien (Chromium (Chromium Hvp Chelate) + Copper (Copper Gluconate) + D-Pantothenic Acid (Calcium D-Pantothenate) + Folic Acid + Nicotinamide + Potassium (Potassium Citrate) + Vitamin a + Vitamin B12 + Vitamin B2 + Vitamin B6 + Vitamin C + Vitamin E (Dl-Alpha Tocopheryl Acetate) + Zinc (Zinc Gluconate))
  • Sterol (Alkyl Dimethyl Ethylbenzyl Ammonium Chloride + Benzalkonium Chloride)
  • Stimu-Pig (Calcium D-Pantothenate + Neomycin (Neomycin Sulfate) + Nicotinic Acid + Pyridoxine Hydrochloride + Streptomycin (Streptomycin Sulfate) + Vitamin a + Vitamin B1 + Vitamin B12 + Vitamin B2 + Vitamin D3)
  • Stop Tablet (Albumin Tannate + Dextrose)
  • Streptocilline - Sp Pws (Calcium D-Pantothenate + Menadione + Nicotinamide + Penicillin G Potassium + Pyridoxine Hydrochloride + Streptomycin Sulfate + Thiamine Hydrochloride + Vitamin a + Vitamin B12 + Vitamin B2 + Vitamin D3 + Vitamin E)
  • Super Chlor 250 (Chlortetracycline + Penicillin (Penicillin G Procaine) + Sulfamethazine)
  • Super Chlorosol 250 Premix (Chlortetracycline Hydrochloride + Penicillin (Penicillin G Procaine) + Sulfamethazine)
  • Super Chlorosol-250 Premix for Swine (Chlortetracycline Hydrochloride + Penicillin G Procaine + Sulfamethazine)
  • Teatino Durazno (Calcium (Calcium Phosphate (Tribasic)) + Chromium (Chromium Hvp Chelate) + Phosphorus (Calcium Phosphate (Tribasic)))
  • Teatino Lemon-Orange (Chromium (Chromium Hvp Chelate) + Copper (Copper Gluconate) + Vitamin a + Vitamin C + Vitamin E (Dl-Alpha Tocopheryl Acetate) + Zinc (Zinc Gluconate))
  • Tnt 100 Cleaner Liq (Alkyl Dimethyl Ethylbenzyl Ammonium Chloride + Benzalkonium Chloride)
  • Trimidox Inj (Sulfadoxine + Trimethoprim)
  • V Dyn Tab (Vitamin a (Fish Liver Oil) + Vitamin B2 + Vitamin E (D-Alpha Tocopheryl Acid Succinate))
  • V Hp (Baptisia Tinctoria + Belladonna + Bryonia + Charcoal Activated + Cinchona Officinalis + Echinacea Angustifolia + Eupatorium Perfoliatum + Gelsemium Sempervirens + Lycopodium Clavatum + Phosphoric Acid + Phosphorus + Poison Ivy)
  • V M Com No 1 a (Selenium Aspartate + Vitamin C + Vitamin E)
  • V-5 Vitlica (Calcium Phosphate (Tribasic) + Phosphoric Acid + Potassium Phosphate Dibasic)
  • V-Balance (Calcium (Calcium Carbonate) + Iron (Ferrous Sulfate) + Vitamin B12 (Cyanocobalamin) + Vitamin B2 + Vitamin D + Zinc (Zinc Sulfate))
  • V-C15 (Cocculus Indicus + Helonias + Lemon + Phosphoric Acid + Sepia Officinalis L + Zinc)
  • V-C15 - Liq (Cocculus Indicus + Helonias + Lemon + Phosphoric Acid + Sepia Officinalis L + Zinc)
  • V-C15f (Cocculus Indicus + Ginseng + Helonias + Phosphoric Acid + Sepia Officinalis L + Zinc)
  • V-Cide (Alcohol Anhydrous + Formaldehyde)
  • V-Lytes (Water Soluble Electrolyte Powder) (Citric Acid + Dextrose + Glycine + Potassium Chloride + Potassium Phosphate Dibasic + Sodium Acetate + Sodium Chloride)
  • V-Lytes He (Water Soluble Nutrient, Electrolyte Powder for Oral Use in Calves) (Citric Acid + Dextrose + Glycine + Potassium Chloride + Potassium Phosphate Dibasic + Sodium Acetate + Sodium Chloride)
  • V.C.F. Tablets (Biotin + Choline (Choline Bitartrate) + Chromium (Chromium Hvp Chelate) + D-Pantothenic Acid (Calcium D-Pantothenate) + Dl-Methionine + Folic Acid + Inositol + Magnesium (Magnesium Oxide) + Manganese (Manganese Gluconate) + Nicotinamide + Nicotinic Acid + Potassium (Potassium Chloride) + Potassium (Potassium Citrate) + Selenium (Selenium Hvp Chelate) + Vitamin a (Vitamin a Palmitate) + Vitamin B1 (Thiamine Hydrochloride) + Vitamin B12 (Vitamin B12) + Vitamin B2 + Vitamin B6 (Pyridoxine Hydrochloride) + Vitamin C (Ascorbic Acid, Calcium Ascorbate) + Vitamin E (D-Alpha Tocopheryl Acid Succinate) + Zinc (Zinc Gluconate))
  • Vetco Probac-V (Benzalkonium Chloride + Didecyl Dimethyl Ammonium Chloride + Octyl Decyl Dimethyl Ammonium Chloride)
  • Vibiomed Fmx (Calcium D-Pantothenate + Dl-Alpha Tocopheryl Acetate + Menadione + Nicotinamide + Penicillin G Potassium + Pyridoxine Hydrochloride + Streptomycin Sulfate + Vitamin a + Vitamin B12 + Vitamin B2 + Vitamin D3)
  • Vit Plex Inj (Cobalt Gluconate + Copper Gluconate + Dexpanthenol + Ferric Ammonium Citrate + Nicotinamide + Pyridoxine Hydrochloride + Soluble Liver Extract + Thiamine Hydrochloride + Vitamin B12 + Vitamin B2)
  • Vitamin Ad3 Forte (Vitamin a and D3 Injection) (Vitamin a Propionate + Vitamin D3)
  • Zoomycetine Spray (Chloramphenicol + Isopropyl Alcohol + Methyl Violet)
Categories
  • Anti-Bacterial Agents
  • Penicillins
CAS number 87-08-1
Weight Average: 350.39
Monoisotopic: 350.093642386
Chemical Formula C16H18N2O5S
InChI Key InChIKey=BPLBGHOLXOTWMN-MBNYWOFBSA-N
InChI
InChI=1S/C16H18N2O5S/c1-16(2)12(15(21)22)18-13(20)11(14(18)24-16)17-10(19)8-23-9-6-4-3-5-7-9/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/t11-,12+,14-/m1/s1
Plain Text
IUPAC Name
(2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenoxyacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
SMILES
[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)COC1=CC=CC=C1)C(O)=O
Plain Text
Mass Spec Not Available
Taxonomy
Kingdom Organic
Classes
  • Phenols and Derivatives
  • Ethers
  • Penicillins
  • Anisoles
  • Phenyl Esters
Substructures
  • Hydroxy Compounds
  • Acetates
  • Phenols and Derivatives
  • Amino Ketones
  • Ethers
  • Benzene and Derivatives
  • Aliphatic and Aryl Amines
  • Carboxylic Acids and Derivatives
  • Beta Lactams
  • Penicillins
  • Thiazoles
  • Heterocyclic compounds
  • Aromatic compounds
  • Anisoles
  • Carboxamides and Derivatives
  • Lactams
  • Azetidines
  • Thiazolidines
  • Phenyl Esters
Pharmacology
Indication For the treatment of mild to moderately severe infections (e.g. dental infection, infections in the heart, middle ear infections, rheumatic fever, scarlet fever, skin infections, upper and lower respiratory tract infections) due to microorganisms
Pharmacodynamics Penicillin V is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Penicillin V has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Penicillin V results from the inhibition of cell wall synthesis and is mediated through Penicillin V binding to penicillin binding proteins (PBPs). Penicillin V is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.
Mechanism of action By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Penicillin V inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Penicillin V interferes with an autolysin inhibitor.
Absorption 25% of the dose given is absorbed, 50-60% bioavailable
Volume of distribution Not Available
Protein binding 80%
Metabolism

About 35-70% of an oral dose is metabolized to penicilloic acid, an inactive metabolite. Small amounts of 6-aminopenicillanic acid have been recovered in the urine of patients on penicillin G. A small percentage of the drug appears to be hydroxylated into one or more active metabolites, which are also excreted via urine.
Route of elimination Mostly renal. A small percentage is eliminated by feces and the biliary route.
Half life 30 to 40 minutes
Clearance Not Available
Toxicity LD50 >1040 mg/kg (Orally in rats with Sodium salt); Nausea, vomiting, stomach pain, diarrhea, and, in rare cases, major motor seizures
Affected organisms
  • Bacteria
Pathways Not Available
Pharmacoeconomics
Manufacturers
  • Eli lilly and co
  • Glaxosmithkline
  • Apothecon inc div bristol myers squibb
  • Lederle laboratories div american cyanamid co
  • Parke davis div warner lambert co
  • American antibiotics llc
  • Dava pharmaceuticals inc
  • Mylan pharmaceuticals inc
  • Purepac pharmaceutical co
  • Teva pharmaceuticals usa inc
  • Wyeth ayerst laboratories
  • Pfizer laboratories div pfizer inc
  • Apothecon sub bristol myers squibb co
  • Bristol laboratories inc div bristol myers co
  • Aurobindo pharma ltd
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Sandoz inc
  • Pharmacia and upjohn co
Packagers
Dosage forms
Form Route Strength
Powder, for solution Oral
Suspension Oral
Tablet Oral
Prices
Unit description Cost Unit
Penicillin V Potassium 250 mg/5ml Solution 100ml Bottle 12.99 USD bottle
Penicillin V Potassium 500 mg tablet 0.77 USD tablet
Penicillin V Potassium 250 mg tablet 0.47 USD tablet
Veetids 500 mg tablet 0.43 USD tablet
Penicillin vk 500 mg tablet 0.4 USD tablet
Veetids 250 mg tablet 0.24 USD tablet
Penicillin vk 250 mg tablet 0.23 USD tablet
Apo-Pen-Vk 300 mg Tablet 0.07 USD tablet
Novo-Pen-Vk 300 mg Tablet 0.07 USD tablet
Nu-Pen-Vk 300 mg Tablet 0.07 USD tablet
Apo-Pen-Vk 25 mg/ml Liquid 0.06 USD ml
Apo-Pen-Vk 60 mg/ml Liquid 0.06 USD ml
Novo-Pen-Vk 60 mg/ml Liquid 0.06 USD ml
Patents Not Available
Properties
State solid
Melting point 120-128 oC
Experimental Properties
Property Value Source
water solubility <0.1 g/100mL PhysProp
logP 1.4 PhysProp
pKa 2.79 Various sources
Predicted Properties
Property Value Source
water solubility 4.54e-01 g/l ALOGPS
logP 1.78 ALOGPS
logP 0.76 ChemAxon Molconvert
logS -2.89 ALOGPS
pKa 11.74 ChemAxon Molconvert
hydrogen acceptor count 5 ChemAxon Molconvert
hydrogen donor count 2 ChemAxon Molconvert
polar surface area 95.94 ChemAxon Molconvert
rotatable bond count 5 ChemAxon Molconvert
refractivity 85.77 ChemAxon Molconvert
polarizability 34.37 ChemAxon Molconvert
References
Synthesis Reference Not Available
General Reference
  1. : Inadvertent use of Bicillin C-R to treat syphilis infection—Los Angeles, California, 1999-2004. MMWR Morb Mortal Wkly Rep. 2005 Mar 11;54(9):217-9. Pubmed
  2. Gruchalla RS, Pirmohamed M: Clinical practice. Antibiotic allergy. N Engl J Med. 2006 Feb 9;354(6):601-9. Pubmed
External Links
Resource Link
KEGG Drug D05411 Link_out
KEGG Compound C08126 Link_out
PubChem Compound 6869 Link_out
PubChem Substance 46507164 Link_out
ChemSpider 6607 Link_out
ChEBI 27446 Link_out
ChEMBL 27446 Link_out
Therapeutic Targets Database DAP001165 Link_out
HET PNV Link_out
Drug Product Database 2229617 Link_out
RxList http://www.rxlist.com/cgi/generic/penvk.htm Link_out
Drugs.com http://www.drugs.com/penicillin.html Link_out
PDRhealth http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/pen1324.shtml Link_out
Wikipedia http://en.wikipedia.org/wiki/Penicillin_V Link_out
ATC Codes
  • J01CE02
  • J01CE10
AHFS Codes
  • 08:12.16.04
PDB Entries Not Available
FDA label Not Available
MSDS show (37.1 KB)
Interactions
Drug Interactions Not Available
Food Interactions
  • Absorption is increased when taken on an empty stomach (one hour before or two hours after meals).
Targets

1. Penicillin-binding proteins 1A/1B

Pharmacological action: yes
Organism class: bacterial
UniProt ID: Q8XJ01 Link_out
Gene: pbpA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

2. MecA PBP2' (penicillin binding protein 2')

Pharmacological action: yes
Actions: inhibitor
Organism class: bacterial
UniProt ID: Q53707 Link_out
Gene: mecA Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Lemaire S, Glupczynski Y, Duval V, Joris B, Tulkens PM, Van Bambeke F: Activities of ceftobiprole and other cephalosporins against extracellular and intracellular (THP-1 macrophages and keratinocytes) forms of methicillin-susceptible and methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2009 Jun;53(6):2289-97. Epub 2009 Mar 16. Pubmed

3. Penicillin-binding protein 4

Pharmacological action: unknown

Not involved in transpeptidation but exclusively catalyzes a DD-carboxypeptidase and DD-endopeptidase reaction

Organism class: bacterial
UniProt ID: P24228 Link_out
Gene: dacB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

4. Penicillin acylase

Pharmacological action: unknown

The enzyme catalyzes the conversion of penicillin to 6- aminopenicillanate The precursor, furthermore, acts as a self- processing peptidase that cleaves off the propeptide. All peptidase activity is lost on conversion to the mature peptidase

Organism class: bacterial
UniProt ID: P12256 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed
Enzymes

1. Beta-lactamase

Actions: substrate
UniProt ID: Q46759 Link_out
Gene: SHV-7 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Martin MT, Waley SG: Kinetic characterization of the acyl-enzyme mechanism for beta-lactamase I. Biochem J. 1988 Sep 15;254(3):923-5. Pubmed
  2. Chan PH, Chan KC, Liu HB, Chung WH, Leung YC, Wong KY: Fluorescein-labeled beta-lactamase mutant for high-throughput screening of bacterial beta-lactamases against beta-lactam antibiotics. Anal Chem. 2005 Aug 15;77(16):5268-76. Pubmed
Transporters
Searched, but no transporters found.
Carriers
Searched, but no carriers found.
Comments
Drug created on June 13, 2005 07:24 / Updated on September 16, 2011 12:18

This project is supported by Genome Alberta & Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $600 million in funding from the federal government. This project is also supported in part by GenomeQuest, Inc., an enterprise genomic information company serving the life science community.