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Identification
NameQuinine
Accession NumberDB00468  (APRD00563)
TypeSmall Molecule
GroupsApproved
DescriptionAn alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood. [PubChem]
Structure
Thumb
Synonyms
(-)-Quinine
(8S,9R)-Quinine
(R)-(-)-Quinine
(R)-(6-Methoxyquinolin-4-yl)((2S,4S,8R)-8-vinylquinuclidin-2-yl)methanol
6'-Methoxycinchonidine
Chinin
Chinine
Chininum
Quinina
Quinine
External Identifiers
  • UNII-KF7Z0E0Q2B
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Jamp-quininecapsule200 mgoralJamp Pharma Corporation2015-09-16Not applicableCanada
Jamp-quininecapsule300 mgoralJamp Pharma Corporation2015-09-16Not applicableCanada
Pro-quinine - 200capsule200 mgoralPro Doc Limitee2008-07-03Not applicableCanada
Pro-quinine - 300capsule300 mgoralPro Doc Limitee2008-07-03Not applicableCanada
Qualaquincapsule324 mg/1oralAR Scientific Inc.2005-08-12Not applicableUs
Qualaquincapsule324 mg/1oralSTAT Rx USA LLC2005-08-12Not applicableUs
Qualaquincapsule324 mg/1oralCaraco Pharma, Inc.2005-08-12Not applicableUs
Quinine - Odancapsule200 mgoralOdan Laboratories Ltd1999-05-01Not applicableCanada
Quinine - Odancapsule300 mgoralOdan Laboratories Ltd1999-05-01Not applicableCanada
Quinine - Odantablet300 mgoralOdan Laboratories Ltd2001-11-08Not applicableCanada
Quinine Sulfatecapsule324 mg/1oralAmerican Health Packaging2015-03-31Not applicableUs
Quinine Sulfatecapsule200 mgoralPendopharm Division Of De Pharmascience IncNot applicableNot applicableCanada
Quinine Sulfatecapsule324 mg/1oralMutual Pharmaceutical Company, Inc.2012-07-23Not applicableUs
Quinine Sulfatecapsule300 mgoralPendopharm Division Of De Pharmascience IncNot applicableNot applicableCanada
Quinine Sulfate Cap 200mgcapsule200 mgoralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1957-12-312001-07-20Canada
Quinine Sulfate Cap 200mgcapsule200 mgoralParke Davis Division, Warner Lambert Canada Inc.1951-12-311998-04-07Canada
Quinine Sulfate Cap 300mgcapsule300 mgoralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1957-12-312001-07-20Canada
Quinine Sulfate Cap 300mgcapsule300 mgoralParke Davis Division, Warner Lambert Canada Inc.1951-12-311998-04-07Canada
Quinine Sulfate Capsules 200mgcapsule200 mgoralD.C. Labs Limited1951-12-312002-04-23Canada
Quinine Sulfate Capsules 300mgcapsule300 mgoralD.C. Labs Limited1951-12-312002-04-23Canada
Teva-quininecapsule300 mgoralTeva Canada Limited1966-12-31Not applicableCanada
Teva-quininecapsule200 mgoralTeva Canada Limited1966-12-31Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-quinine Capsulescapsule200 mgoralApotex Inc2004-06-08Not applicableCanada
Apo-quinine Capsulescapsule300 mgoralApotex Inc2004-06-08Not applicableCanada
Quinine Sulfatecapsule324 mg/1oralTeva Pharmaceuticals USA Inc2012-09-28Not applicableUs
Quinine Sulfatecapsule324 mg/1oralLupin Pharmaceuticals, Inc.2015-08-04Not applicableUs
Quinine Sulfatecapsule324 mg/1oralMylan Pharmaceuticals Inc.2012-12-14Not applicableUs
Quinine Sulfatecapsule324 mg/1oralRiconpharma Llc2015-07-23Not applicableUs
Quinine Sulfatecapsule324 mg/1oralCore Pharma, Llc2015-07-23Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
CinkonaIpca
JasoquinJayson
QSMLeben
QuinlupLupin
QutilLittle Greave
SulquinSaga
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Quinine Hydrochloride
ThumbNot applicableDBSALT001044
Quinine sulfate
804-63-7
Thumb
  • InChI Key: RONWGALEIBILOG-VMJVVOMYSA-N
  • Monoisotopic Mass: 746.334935286
  • Average Mass: 746.912
DBSALT000531
Categories
UNIIA7V27PHC7A
CAS number130-95-0
WeightAverage: 324.4168
Monoisotopic: 324.183778022
Chemical FormulaC20H24N2O2
InChI KeyInChIKey=LOUPRKONTZGTKE-WZBLMQSHSA-N
InChI
InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19-,20+/m0/s1
IUPAC Name
(R)-[(1S,2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol
SMILES
[H][C@]1(C[C@@H]2CC[N@]1C[C@@H]2C=C)[[email protected]](O)C1=CC=NC2=CC=C(OC)C=C12
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as cinchona alkaloids. These are alkaloids structurally characterized by the presence of the cinchonan skeleton, which consists of a quinoline linked to an azabicyclo[2.2.2]octane moiety.
KingdomOrganic compounds
Super ClassAlkaloids and derivatives
ClassCinchona alkaloids
Sub ClassNot Available
Direct ParentCinchona alkaloids
Alternative Parents
Substituents
  • Cinchonan-skeleton
  • Hydroxyquinoline
  • Quinoline
  • Quinuclidine
  • Anisole
  • Aralkylamine
  • Alkyl aryl ether
  • Benzenoid
  • Pyridine
  • Piperidine
  • Heteroaromatic compound
  • Tertiary aliphatic amine
  • Tertiary amine
  • Secondary alcohol
  • 1,2-aminoalcohol
  • Azacycle
  • Organoheterocyclic compound
  • Ether
  • Hydrocarbon derivative
  • Aromatic alcohol
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Alcohol
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of malaria and leg cramps
PharmacodynamicsQuinine is used parenterally to treat life-threatening infections caused by chloroquine-resistant Plasmodium falciparum malaria. Quinine acts as a blood schizonticide although it also has gametocytocidal activity against P. vivax and P. malariae. Because it is a weak base, it is concentrated in the food vacuoles of P. falciparum. It is thought to act by inhibiting heme polymerase, thereby allowing accumulation of its cytotoxic substrate, heme. As a schizonticidal drug, it is less effective and more toxic than chloroquine. However, it has a special place in the management of severe falciparum malaria in areas with known resistance to chloroquine.
Mechanism of actionThe theorized mechanism of action for quinine and related anti-malarial drugs is that these drugs are toxic to the malaria parasite. Specifically, the drugs interfere with the parasite's ability to break down and digest hemoglobin. Consequently, the parasite starves and/or builds up toxic levels of partially degraded hemoglobin in itself.
Related Articles
Absorption76 - 88%
Volume of distribution
  • 1.43 ± 0.18 L/kg [Healthy Pediatric Controls]
  • 0.87 ± 0.12 L/kg [P. falciparum Malaria Pediatric Patients]
  • 2.5 to 7.1 L/kg [healthy subjects who received a single oral 600 mg dose]
Protein bindingApproximately 70%
Metabolism

Hepatic, over 80% metabolized by the liver.

SubstrateEnzymesProduct
Quinine
3-hydroxyquinineDetails
Route of eliminationQuinine is eliminated primarily via hepatic biotransformation. Approximately 20% of quinine is excreted unchanged in urine.
Half lifeApproximately 18 hours
Clearance
  • 0.17 L/h/kg [healthy]
  • 0.09 L/h/kg [patients with uncomplicated malaria]
  • 18.4 L/h [healthy adult subjects with administration of multiple-dose activated charcoal]
  • 11.8 L/h [healthy adult subjects without administration of multiple-dose activated charcoal]
  • Oral cl=0.06 L/h/kg [elderly subjects]
ToxicityQuinine is a documented causative agent of drug induced thrombocytopenia (DIT). Thrombocytopenia is a low amount of platelets in the blood. Quinine induces production of antibodies against glycoprotein (GP) Ib-IX complex in the majority of cases of DIT, or more rarely, the platelet-glycoprotein complex GPIIb-IIIa. Increased antibodies against these complexes increases platelet clearance, leading to the observed thrombocytopenia.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9836
Blood Brain Barrier+0.9382
Caco-2 permeable+0.8867
P-glycoprotein substrateSubstrate0.7863
P-glycoprotein inhibitor IInhibitor0.8208
P-glycoprotein inhibitor IIInhibitor0.8387
Renal organic cation transporterInhibitor0.762
CYP450 2C9 substrateNon-substrate0.7898
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.5754
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorInhibitor0.8931
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorNon-inhibitor0.8309
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7225
Ames testNon AMES toxic0.9133
CarcinogenicityNon-carcinogens0.972
BiodegradationNot ready biodegradable1.0
Rat acute toxicity3.0596 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Strong inhibitor0.5884
hERG inhibition (predictor II)Inhibitor0.538
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Ar holding co inc
Packagers
Dosage forms
FormRouteStrength
Capsuleoral200 mg
Tabletoral300 mg
Capsuleoral324 mg/1
Capsuleoral300 mg
Prices
Unit descriptionCostUnit
Quinine sulfate powd ultrex25.86USD g
Apo-Quinine 300 mg Capsule0.39USD capsule
Novo-Quinine 300 mg Capsule0.39USD capsule
Apo-Quinine 200 mg Capsule0.25USD capsule
Novo-Quinine 200 mg Capsule0.25USD capsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point57 °CPhysProp
water solubility500 mg/L (at 15 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP3.44HANSCH,C ET AL. (1995)
logS-2.76ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility0.334 mg/mLALOGPS
logP2.82ALOGPS
logP2.51ChemAxon
logS-3ALOGPS
pKa (Strongest Acidic)13.89ChemAxon
pKa (Strongest Basic)9.05ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area45.59 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity94.69 m3·mol-1ChemAxon
Polarizability35.96 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

Tong Sun, Shawn Watson, Wei Lai, Stephan D. Parent, “QUININE SULFATE/BISULFATE SOLID COMPLEX; METHODS OF MAKING; AND METHODS OF USE THEREOF.” U.S. Patent US20090326005, issued December 31, 2009.

US20090326005
General References
  1. Paintaud G, Alvan G, Berninger E, Gustafsson LL, Idrizbegovic E, Karlsson KK, Wakelkamp M: The concentration-effect relationship of quinine-induced hearing impairment. Clin Pharmacol Ther. 1994 Mar;55(3):317-23. [PubMed:8143397 ]
External Links
ATC CodesP01BC01M09AA72
AHFS Codes
  • 08:30.08
  • 92:02.00*
PDB EntriesNot Available
FDA labelDownload (718 KB)
MSDSDownload (72.1 KB)
Interactions
Drug Interactions
Drug
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Quinine.
7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE may increase the hypoglycemic activities of Quinine.
AbirateroneThe serum concentration of Quinine can be increased when it is combined with Abiraterone.
AcarboseAcarbose may increase the hypoglycemic activities of Quinine.
AcebutololQuinine may increase the hypotensive activities of Acebutolol.
AceclofenacThe metabolism of Aceclofenac can be decreased when combined with Quinine.
AcenocoumarolQuinine may increase the anticoagulant activities of Acenocoumarol.
AcepromazineThe serum concentration of Acepromazine can be increased when it is combined with Quinine.
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Quinine.
AcetohexamideAcetohexamide may increase the hypoglycemic activities of Quinine.
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Quinine.
Acetylsalicylic acidAcetylsalicylic acid may increase the hypoglycemic activities of Quinine.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Quinine.
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Quinine.
AicarAicar may increase the hypoglycemic activities of Quinine.
AjmalineThe metabolism of Ajmaline can be decreased when combined with Quinine.
AlbendazoleThe serum concentration of Quinine can be increased when it is combined with Albendazole.
AldosteroneThe serum concentration of Quinine can be decreased when it is combined with Aldosterone.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Quinine.
AlectinibThe serum concentration of Quinine can be increased when it is combined with Alectinib.
AlfentanilThe serum concentration of Quinine can be increased when it is combined with Alfentanil.
AlfuzosinAlfuzosin may increase the QTc-prolonging activities of Quinine.
AlimemazineThe serum concentration of Alimemazine can be increased when it is combined with Quinine.
AliskirenQuinine may increase the hypotensive activities of Aliskiren.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Quinine.
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Quinine.
AlogliptinAlogliptin may increase the hypoglycemic activities of Quinine.
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Quinine.
AlosetronThe metabolism of Alosetron can be decreased when combined with Quinine.
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Quinine.
AlprenololQuinine may increase the hypotensive activities of Alprenolol.
Aluminum hydroxideThe serum concentration of Quinine can be decreased when it is combined with Aluminum hydroxide.
Aluminum phosphateThe serum concentration of Quinine can be decreased when it is combined with Aluminum phosphate.
AmantadineThe serum concentration of Quinine can be increased when it is combined with Amantadine.
AmbrisentanQuinine may increase the hypotensive activities of Ambrisentan.
Aminohippuric acidThe serum concentration of Quinine can be increased when it is combined with Aminohippuric acid.
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Quinine.
AminophyllineThe serum concentration of Aminophylline can be increased when it is combined with Quinine.
Aminosalicylic AcidAminosalicylic Acid may increase the hypoglycemic activities of Quinine.
AmiodaroneQuinine may increase the QTc-prolonging activities of Amiodarone.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Quinine.
AmlodipineQuinine may increase the hypotensive activities of Amlodipine.
AmlodipineThe serum concentration of Quinine can be increased when it is combined with Amlodipine.
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Quinine.
AmoxapineAmoxapine may increase the hypoglycemic activities of Quinine.
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Quinine.
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Quinine.
AmprenavirThe serum concentration of Quinine can be decreased when it is combined with Amprenavir.
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Quinine.
AmsacrineThe serum concentration of Quinine can be increased when it is combined with Amsacrine.
AmsacrineThe metabolism of Amsacrine can be decreased when combined with Quinine.
AnagrelideAnagrelide may increase the QTc-prolonging activities of Quinine.
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Quinine.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Quinine.
ApomorphineApomorphine may increase the QTc-prolonging activities of Quinine.
AprepitantThe serum concentration of Quinine can be increased when it is combined with Aprepitant.
AprindineThe metabolism of Aprindine can be decreased when combined with Quinine.
Arachidonic AcidThe metabolism of Arachidonic Acid can be decreased when combined with Quinine.
ArformoterolArformoterol may increase the QTc-prolonging activities of Quinine.
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Quinine.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Quinine.
AripiprazoleAripiprazole may increase the QTc-prolonging activities of Quinine.
ArmodafinilThe metabolism of Quinine can be decreased when combined with Armodafinil.
Arsenic trioxideQuinine may increase the QTc-prolonging activities of Arsenic trioxide.
ArtemetherThe risk or severity of adverse effects can be increased when Artemether is combined with Quinine.
ArtemetherQuinine may increase the QTc-prolonging activities of Artemether.
AsenapineQuinine may increase the QTc-prolonging activities of Asenapine.
AstemizoleThe serum concentration of Quinine can be increased when it is combined with Astemizole.
AstemizoleThe metabolism of Astemizole can be decreased when combined with Quinine.
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Quinine.
AtenololQuinine may increase the hypotensive activities of Atenolol.
AtenololThe serum concentration of Quinine can be increased when it is combined with Atenolol.
AtomoxetineThe metabolism of Quinine can be decreased when combined with Atomoxetine.
AtorvastatinThe serum concentration of Quinine can be increased when it is combined with Atorvastatin.
AtorvastatinThe metabolism of Atorvastatin can be decreased when combined with Quinine.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Quinine.
AzelastineThe serum concentration of Quinine can be increased when it is combined with Azelastine.
AzelastineThe metabolism of Azelastine can be decreased when combined with Quinine.
AzithromycinAzithromycin may increase the QTc-prolonging activities of Quinine.
BedaquilineBedaquiline may increase the QTc-prolonging activities of Quinine.
BenazeprilQuinine may increase the hypotensive activities of Benazepril.
BendroflumethiazideQuinine may increase the hypotensive activities of Bendroflumethiazide.
BenmoxinBenmoxin may increase the hypoglycemic activities of Quinine.
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Quinine.
BenzocaineThe serum concentration of Quinine can be increased when it is combined with Benzocaine.
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Quinine.
BepridilQuinine may increase the hypotensive activities of Bepridil.
BepridilThe serum concentration of Quinine can be increased when it is combined with Bepridil.
BeraprostThe metabolism of Beraprost can be decreased when combined with Quinine.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Quinine.
BetaxololQuinine may increase the hypotensive activities of Betaxolol.
BetaxololThe metabolism of Quinine can be decreased when combined with Betaxolol.
BethanidineQuinine may increase the hypotensive activities of Bethanidine.
BexaroteneThe serum concentration of Quinine can be decreased when it is combined with Bexarotene.
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Quinine.
BimatoprostQuinine may increase the hypotensive activities of Bimatoprost.
BiperidenThe serum concentration of Quinine can be increased when it is combined with Biperiden.
Bismuth SubcitrateThe serum concentration of Quinine can be decreased when it is combined with Bismuth Subcitrate.
BisoprololQuinine may increase the hypotensive activities of Bisoprolol.
BoceprevirThe metabolism of Quinine can be decreased when combined with Boceprevir.
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Quinine.
BortezomibThe metabolism of Quinine can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Quinine can be decreased when it is combined with Bosentan.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Quinine.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Quinine.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Quinine.
BretyliumQuinine may increase the hypotensive activities of Bretylium.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Quinine.
BrimonidineQuinine may increase the hypotensive activities of Brimonidine.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Quinine.
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Quinine.
BuforminBuformin may increase the hypoglycemic activities of Quinine.
BufuralolThe metabolism of Bufuralol can be decreased when combined with Quinine.
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Quinine.
BupranololQuinine may increase the hypotensive activities of Bupranolol.
BuprenorphineThe serum concentration of Quinine can be increased when it is combined with Buprenorphine.
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Quinine.
BupropionThe metabolism of Bupropion can be decreased when combined with Quinine.
BuserelinBuserelin may increase the QTc-prolonging activities of Quinine.
BuspironeThe serum concentration of Quinine can be increased when it is combined with Buspirone.
BuspironeThe metabolism of Buspirone can be decreased when combined with Quinine.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Quinine.
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Quinine.
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Quinine.
Calcium carbonateThe serum concentration of Quinine can be decreased when it is combined with Calcium carbonate.
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Quinine.
CanagliflozinCanagliflozin may increase the hypoglycemic activities of Quinine.
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Quinine.
CandesartanQuinine may increase the hypotensive activities of Candesartan.
CandesartanThe serum concentration of Quinine can be increased when it is combined with Candesartan.
CandoxatrilQuinine may increase the hypotensive activities of Candoxatril.
CapecitabineThe metabolism of Quinine can be decreased when combined with Capecitabine.
CaptoprilQuinine may increase the hypotensive activities of Captopril.
CaptoprilThe serum concentration of Quinine can be increased when it is combined with Captopril.
CarbamazepineThe serum concentration of Quinine can be decreased when it is combined with Carbamazepine.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Quinine.
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Quinine.
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Quinine.
CariprazineThe metabolism of Cariprazine can be decreased when combined with Quinine.
CaroxazoneCaroxazone may increase the hypoglycemic activities of Quinine.
CarteololQuinine may increase the hypotensive activities of Carteolol.
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Quinine.
CaspofunginThe serum concentration of Quinine can be increased when it is combined with Caspofungin.
CastanospermineCastanospermine may increase the hypoglycemic activities of Quinine.
CelecoxibThe metabolism of Quinine can be decreased when combined with Celecoxib.
CeliprololQuinine may increase the hypotensive activities of Celiprolol.
CephalexinThe metabolism of Cephalexin can be decreased when combined with Quinine.
CeritinibCeritinib may increase the QTc-prolonging activities of Quinine.
CeritinibThe serum concentration of Ceritinib can be increased when it is combined with Quinine.
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Quinine.
CevimelineThe metabolism of Cevimeline can be decreased when combined with Quinine.
ChloramphenicolThe metabolism of Quinine can be decreased when combined with Chloramphenicol.
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Quinine.
ChloroquineChloroquine may increase the QTc-prolonging activities of Quinine.
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Quinine.
ChlorothiazideQuinine may increase the hypotensive activities of Chlorothiazide.
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Quinine.
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Quinine.
ChlorpromazineChlorpromazine may increase the QTc-prolonging activities of Quinine.
ChlorpropamideChlorpropamide may increase the hypoglycemic activities of Quinine.
ChlorprothixeneThe serum concentration of Quinine can be increased when it is combined with Chlorprothixene.
ChlorthalidoneQuinine may increase the hypotensive activities of Chlorthalidone.
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Quinine.
CholecalciferolThe metabolism of Quinine can be decreased when combined with Cholecalciferol.
CholesterolThe serum concentration of Quinine can be increased when it is combined with Cholesterol.
Cholic AcidThe serum concentration of Quinine can be decreased when it is combined with Cholic Acid.
CiglitazoneCiglitazone may increase the hypoglycemic activities of Quinine.
CilazaprilQuinine may increase the hypotensive activities of Cilazapril.
CilazaprilThe serum concentration of Quinine can be increased when it is combined with Cilazapril.
CilostazolThe metabolism of Cilostazol can be decreased when combined with Quinine.
CimetidineThe serum concentration of Quinine can be decreased when it is combined with Cimetidine.
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Quinine.
CinacalcetThe metabolism of Quinine can be decreased when combined with Cinacalcet.
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Quinine.
CiprofloxacinCiprofloxacin may increase the QTc-prolonging activities of Quinine.
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Quinine.
CisaprideQuinine may increase the QTc-prolonging activities of Cisapride.
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Quinine.
CitalopramCitalopram may increase the QTc-prolonging activities of Quinine.
ClarithromycinClarithromycin may increase the QTc-prolonging activities of Quinine.
ClarithromycinThe serum concentration of Clarithromycin can be increased when it is combined with Quinine.
ClemastineThe metabolism of Quinine can be decreased when combined with Clemastine.
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Quinine.
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Quinine.
ClobazamThe metabolism of Quinine can be decreased when combined with Clobazam.
ClofazimineThe serum concentration of Quinine can be increased when it is combined with Clofazimine.
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Quinine.
ClomipramineClomipramine may increase the hypoglycemic activities of Quinine.
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Quinine.
ClonidineQuinine may increase the hypotensive activities of Clonidine.
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Quinine.
ClopidogrelThe metabolism of Quinine can be decreased when combined with Clopidogrel.
ClotrimazoleThe metabolism of Quinine can be decreased when combined with Clotrimazole.
ClozapineClozapine may increase the QTc-prolonging activities of Quinine.
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Quinine.
CobicistatThe serum concentration of Quinine can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Quinine.
CocaineThe metabolism of Quinine can be decreased when combined with Cocaine.
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Quinine.
Coenzyme Q10The serum concentration of Coenzyme Q10 can be increased when it is combined with Quinine.
ColchicineThe serum concentration of Quinine can be increased when it is combined with Colchicine.
ColforsinThe serum concentration of Quinine can be increased when it is combined with Colforsin.
ConivaptanThe serum concentration of Quinine can be increased when it is combined with Conivaptan.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Quinine.
CrizotinibCrizotinib may increase the QTc-prolonging activities of Quinine.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Quinine.
CryptenamineQuinine may increase the hypotensive activities of Cryptenamine.
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Quinine.
CyclophosphamideThe serum concentration of Quinine can be increased when it is combined with Cyclophosphamide.
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Quinine.
CyclosporineThe metabolism of Quinine can be decreased when combined with Cyclosporine.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Quinine.
CyclothiazideQuinine may increase the hypotensive activities of Cyclothiazide.
Cyproterone acetateThe serum concentration of Quinine can be decreased when it is combined with Cyproterone acetate.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Quinine.
DabrafenibThe serum concentration of Quinine can be decreased when it is combined with Dabrafenib.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Quinine.
DaclatasvirThe serum concentration of Quinine can be increased when it is combined with Daclatasvir.
DactinomycinThe serum concentration of Quinine can be increased when it is combined with Dactinomycin.
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Quinine.
DapoxetineDapoxetine may increase the hypoglycemic activities of Quinine.
DapsoneThe risk or severity of adverse effects can be increased when Dapsone is combined with Quinine.
DapsoneThe metabolism of Dapsone can be decreased when combined with Quinine.
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Quinine.
DarunavirThe serum concentration of Quinine can be increased when it is combined with Darunavir.
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Quinine.
DasatinibThe serum concentration of Quinine can be increased when it is combined with Dasatinib.
DaunorubicinThe serum concentration of Quinine can be decreased when it is combined with Daunorubicin.
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Quinine.
DebrisoquinQuinine may increase the hypotensive activities of Debrisoquin.
DeferasiroxThe serum concentration of Quinine can be decreased when it is combined with Deferasirox.
DegarelixDegarelix may increase the QTc-prolonging activities of Quinine.
DelavirdineThe metabolism of Quinine can be decreased when combined with Delavirdine.
DeserpidineQuinine may increase the hypotensive activities of Deserpidine.
DesfluraneDesflurane may increase the QTc-prolonging activities of Quinine.
DesipramineThe serum concentration of Quinine can be increased when it is combined with Desipramine.
DesipramineThe metabolism of Desipramine can be decreased when combined with Quinine.
DesloratadineThe serum concentration of Quinine can be increased when it is combined with Desloratadine.
DexamethasoneThe serum concentration of Quinine can be decreased when it is combined with Dexamethasone.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Quinine.
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Quinine.
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Quinine.
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Quinine.
DextromethorphanThe serum concentration of Quinine can be increased when it is combined with Dextromethorphan.
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Quinine.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Quinine.
DiazoxideQuinine may increase the hypotensive activities of Diazoxide.
DiclofenacThe serum concentration of Quinine can be increased when it is combined with Diclofenac.
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Quinine.
DicoumarolQuinine may increase the anticoagulant activities of Dicoumarol.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Quinine.
DiflunisalDiflunisal may increase the hypoglycemic activities of Quinine.
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Quinine.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Quinine.
DigoxinThe serum concentration of Quinine can be decreased when it is combined with Digoxin.
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Quinine.
DihydroergotamineThe metabolism of Quinine can be decreased when combined with Dihydroergotamine.
DihydrotestosteroneDihydrotestosterone may increase the hypoglycemic activities of Quinine.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Quinine.
DiltiazemQuinine may increase the hypotensive activities of Diltiazem.
DiltiazemThe metabolism of Quinine can be decreased when combined with Diltiazem.
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Quinine.
DipyridamoleThe serum concentration of Quinine can be increased when it is combined with Dipyridamole.
DisopyramideDisopyramide may increase the QTc-prolonging activities of Quinine.
DisulfiramThe metabolism of Quinine can be decreased when combined with Disulfiram.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Quinine.
DofetilideDofetilide may increase the QTc-prolonging activities of Quinine.
DolasetronDolasetron may increase the QTc-prolonging activities of Quinine.
DolasetronThe metabolism of Dolasetron can be decreased when combined with Quinine.
DomperidoneQuinine may increase the QTc-prolonging activities of Domperidone.
DonepezilThe metabolism of Donepezil can be decreased when combined with Quinine.
DopamineThe metabolism of Dopamine can be decreased when combined with Quinine.
DorzolamideQuinine may increase the hypotensive activities of Dorzolamide.
DoxazosinQuinine may increase the hypotensive activities of Doxazosin.
DoxazosinThe serum concentration of Quinine can be increased when it is combined with Doxazosin.
DoxepinThe serum concentration of Quinine can be increased when it is combined with Doxepin.
DoxepinThe metabolism of Doxepin can be decreased when combined with Quinine.
DoxorubicinThe serum concentration of Quinine can be decreased when it is combined with Doxorubicin.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Quinine.
DoxycyclineThe metabolism of Quinine can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Quinine.
DronedaroneQuinine may increase the QTc-prolonging activities of Dronedarone.
DroperidolDroperidol may increase the QTc-prolonging activities of Quinine.
DulaglutideDulaglutide may increase the hypoglycemic activities of Quinine.
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Quinine.
DyphyllineThe serum concentration of Dyphylline can be increased when it is combined with Quinine.
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Quinine.
EfavirenzThe serum concentration of Quinine can be decreased when it is combined with Efavirenz.
EfonidipineQuinine may increase the hypotensive activities of Efonidipine.
ElbasvirThe serum concentration of Quinine can be increased when it is combined with Elbasvir.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Quinine.
EliglustatQuinine may increase the QTc-prolonging activities of Eliglustat.
EltrombopagThe metabolism of Eltrombopag can be decreased when combined with Quinine.
EmpagliflozinEmpagliflozin may increase the hypoglycemic activities of Quinine.
EnalaprilQuinine may increase the hypotensive activities of Enalapril.
EnalaprilThe serum concentration of Quinine can be increased when it is combined with Enalapril.
EnalaprilatQuinine may increase the hypotensive activities of Enalaprilat.
EncainideThe metabolism of Encainide can be decreased when combined with Quinine.
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Quinine.
EnzalutamideThe serum concentration of Quinine can be increased when it is combined with Enzalutamide.
EnzalutamideThe metabolism of Enzalutamide can be decreased when combined with Quinine.
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Quinine.
EpoprostenolQuinine may increase the hypotensive activities of Epoprostenol.
EprosartanQuinine may increase the hypotensive activities of Eprosartan.
ErgonovineThe serum concentration of Quinine can be increased when it is combined with Ergonovine.
ErgotamineThe serum concentration of Quinine can be increased when it is combined with Ergotamine.
EribulinEribulin may increase the QTc-prolonging activities of Quinine.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Quinine.
ErythromycinErythromycin may increase the QTc-prolonging activities of Quinine.
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Quinine.
EscitalopramQuinine may increase the QTc-prolonging activities of Escitalopram.
Eslicarbazepine acetateThe serum concentration of Quinine can be decreased when it is combined with Eslicarbazepine acetate.
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Quinine.
EsomeprazoleThe metabolism of Quinine can be decreased when combined with Esomeprazole.
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Quinine.
EstramustineThe serum concentration of Quinine can be increased when it is combined with Estramustine.
EstriolThe serum concentration of Quinine can be decreased when it is combined with Estriol.
EstriolThe serum concentration of Estriol can be increased when it is combined with Quinine.
EstroneThe serum concentration of Quinine can be decreased when it is combined with Estrone.
EstroneThe serum concentration of Estrone can be increased when it is combined with Quinine.
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Quinine.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Quinine.
Ethyl biscoumacetateQuinine may increase the anticoagulant activities of Ethyl biscoumacetate.
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Quinine.
EtodolacThe metabolism of Etodolac can be decreased when combined with Quinine.
EtoperidoneEtoperidone may increase the hypoglycemic activities of Quinine.
EtoposideThe serum concentration of Quinine can be increased when it is combined with Etoposide.
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Quinine.
EtravirineThe serum concentration of Quinine can be decreased when it is combined with Etravirine.
EtravirineThe metabolism of Etravirine can be decreased when combined with Quinine.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Quinine.
ExenatideExenatide may increase the hypoglycemic activities of Quinine.
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Quinine.
EzogabineEzogabine may increase the QTc-prolonging activities of Quinine.
FamotidineFamotidine may increase the QTc-prolonging activities of Quinine.
FelbamateFelbamate may increase the QTc-prolonging activities of Quinine.
FelodipineQuinine may increase the hypotensive activities of Felodipine.
FelodipineThe serum concentration of Quinine can be increased when it is combined with Felodipine.
FenfluramineFenfluramine may increase the hypoglycemic activities of Quinine.
FenoldopamQuinine may increase the hypotensive activities of Fenoldopam.
FentanylThe serum concentration of Quinine can be increased when it is combined with Fentanyl.
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Quinine.
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Quinine.
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Quinine.
FingolimodFingolimod may increase the QTc-prolonging activities of Quinine.
FingolimodThe metabolism of Fingolimod can be decreased when combined with Quinine.
FlecainideFlecainide may increase the QTc-prolonging activities of Quinine.
FlecainideThe metabolism of Flecainide can be decreased when combined with Quinine.
FloxuridineThe metabolism of Quinine can be decreased when combined with Floxuridine.
FluconazoleThe metabolism of Quinine can be decreased when combined with Fluconazole.
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Quinine.
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Quinine.
FluorouracilThe metabolism of Quinine can be decreased when combined with Fluorouracil.
FluoxetineQuinine may increase the QTc-prolonging activities of Fluoxetine.
FluoxymesteroneFluoxymesterone may increase the hypoglycemic activities of Quinine.
FlupentixolQuinine may increase the QTc-prolonging activities of Flupentixol.
FluphenazineThe serum concentration of Fluphenazine can be increased when it is combined with Quinine.
FlurazepamThe serum concentration of Quinine can be increased when it is combined with Flurazepam.
FlurbiprofenThe metabolism of Flurbiprofen can be decreased when combined with Quinine.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Quinine.
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Quinine.
FluvoxamineFluvoxamine may increase the hypoglycemic activities of Quinine.
FluvoxamineThe metabolism of Fluvoxamine can be decreased when combined with Quinine.
FormoterolFormoterol may increase the QTc-prolonging activities of Quinine.
FormoterolThe metabolism of Formoterol can be decreased when combined with Quinine.
FosamprenavirThe metabolism of Quinine can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Quinine can be increased when it is combined with Fosaprepitant.
FoscarnetFoscarnet may increase the QTc-prolonging activities of Quinine.
FosinoprilQuinine may increase the hypotensive activities of Fosinopril.
FosphenytoinThe serum concentration of Quinine can be decreased when it is combined with Fosphenytoin.
FosphenytoinThe metabolism of Fosphenytoin can be decreased when combined with Quinine.
FurazolidoneFurazolidone may increase the hypoglycemic activities of Quinine.
Fusidic AcidThe serum concentration of Quinine can be increased when it is combined with Fusidic Acid.
Gadobenic acidGadobenic acid may increase the QTc-prolonging activities of Quinine.
GalantamineGalantamine may increase the QTc-prolonging activities of Quinine.
GalantamineThe metabolism of Galantamine can be decreased when combined with Quinine.
GavestinelThe metabolism of Gavestinel can be decreased when combined with Quinine.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Quinine.
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Quinine.
GemfibrozilThe metabolism of Quinine can be decreased when combined with Gemfibrozil.
GemifloxacinGemifloxacin may increase the QTc-prolonging activities of Quinine.
GenisteinThe serum concentration of Quinine can be increased when it is combined with Genistein.
GlibornurideGlibornuride may increase the hypoglycemic activities of Quinine.
GliclazideGliclazide may increase the hypoglycemic activities of Quinine.
GlimepirideGlimepiride may increase the hypoglycemic activities of Quinine.
GlipizideGlipizide may increase the hypoglycemic activities of Quinine.
GliquidoneGliquidone may increase the hypoglycemic activities of Quinine.
GlyburideGlyburide may increase the hypoglycemic activities of Quinine.
GlycerolThe serum concentration of Quinine can be increased when it is combined with Glycerol.
GoserelinGoserelin may increase the QTc-prolonging activities of Quinine.
Gramicidin DThe serum concentration of Quinine can be increased when it is combined with Gramicidin D.
GranisetronGranisetron may increase the QTc-prolonging activities of Quinine.
GranisetronThe metabolism of Granisetron can be decreased when combined with Quinine.
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Quinine.
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Quinine.
GuanabenzQuinine may increase the hypotensive activities of Guanabenz.
GuanadrelQuinine may increase the hypotensive activities of Guanadrel.
GuanethidineQuinine may increase the hypotensive activities of Guanethidine.
GuanfacineQuinine may increase the hypotensive activities of Guanfacine.
HalofantrineThe risk or severity of adverse effects can be increased when Quinine is combined with Halofantrine.
HaloperidolHaloperidol may increase the QTc-prolonging activities of Quinine.
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Quinine.
HalothaneThe metabolism of Halothane can be decreased when combined with Quinine.
HexamethoniumQuinine may increase the hypotensive activities of Hexamethonium.
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Quinine.
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Quinine.
HistrelinHistrelin may increase the QTc-prolonging activities of Quinine.
HydracarbazineHydracarbazine may increase the hypoglycemic activities of Quinine.
HydralazineQuinine may increase the hypotensive activities of Hydralazine.
HydrochlorothiazideQuinine may increase the hypotensive activities of Hydrochlorothiazide.
HydrocodoneThe metabolism of Hydrocodone can be decreased when combined with Quinine.
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Quinine.
HydroflumethiazideQuinine may increase the hypotensive activities of Hydroflumethiazide.
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Quinine.
HydroxyzineHydroxyzine may increase the QTc-prolonging activities of Quinine.
IbandronateIbandronate may increase the QTc-prolonging activities of Quinine.
IbrutinibThe metabolism of Ibrutinib can be decreased when combined with Quinine.
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Quinine.
IbutilideIbutilide may increase the QTc-prolonging activities of Quinine.
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Quinine.
IdelalisibThe serum concentration of Quinine can be increased when it is combined with Idelalisib.
IfosfamideThe metabolism of Ifosfamide can be decreased when combined with Quinine.
IloperidoneQuinine may increase the QTc-prolonging activities of Iloperidone.
ImatinibThe metabolism of Quinine can be decreased when combined with Imatinib.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Quinine.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Quinine.
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Quinine.
IndacaterolIndacaterol may increase the QTc-prolonging activities of Quinine.
IndalpineIndalpine may increase the hypoglycemic activities of Quinine.
IndapamideQuinine may increase the hypotensive activities of Indapamide.
IndapamideIndapamide may increase the QTc-prolonging activities of Quinine.
IndenololQuinine may increase the hypotensive activities of Indenolol.
IndinavirThe serum concentration of Quinine can be decreased when it is combined with Indinavir.
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Quinine.
indisulamThe metabolism of indisulam can be decreased when combined with Quinine.
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Quinine.
IndoraminQuinine may increase the hypotensive activities of Indoramin.
Insulin AspartInsulin Aspart may increase the hypoglycemic activities of Quinine.
Insulin DetemirInsulin Detemir may increase the hypoglycemic activities of Quinine.
Insulin GlargineInsulin Glargine may increase the hypoglycemic activities of Quinine.
Insulin GlulisineInsulin Glulisine may increase the hypoglycemic activities of Quinine.
Insulin HumanInsulin Human may increase the hypoglycemic activities of Quinine.
Insulin LisproInsulin Lispro may increase the hypoglycemic activities of Quinine.
Insulin PorkInsulin Pork may increase the hypoglycemic activities of Quinine.
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Quinine.
IproclozideIproclozide may increase the hypoglycemic activities of Quinine.
IproniazidIproniazid may increase the hypoglycemic activities of Quinine.
IrbesartanQuinine may increase the hypotensive activities of Irbesartan.
IrbesartanThe metabolism of Quinine can be decreased when combined with Irbesartan.
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Quinine.
IsavuconazoniumThe metabolism of Quinine can be decreased when combined with Isavuconazonium.
IsocarboxazidIsocarboxazid may increase the hypoglycemic activities of Quinine.
IsofluraneIsoflurane may increase the QTc-prolonging activities of Quinine.
IsoniazidThe metabolism of Quinine can be decreased when combined with Isoniazid.
IsradipineQuinine may increase the hypotensive activities of Isradipine.
IsradipineThe metabolism of Quinine can be decreased when combined with Isradipine.
ItraconazoleThe serum concentration of Quinine can be increased when it is combined with Itraconazole.
IvabradineIvabradine may increase the QTc-prolonging activities of Quinine.
IvacaftorThe serum concentration of Quinine can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Quinine.
IxazomibThe metabolism of Ixazomib can be decreased when combined with Quinine.
KetamineThe serum concentration of Quinine can be increased when it is combined with Ketamine.
KetamineThe metabolism of Ketamine can be decreased when combined with Quinine.
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Quinine.
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Quinine.
KetoconazoleThe serum concentration of Quinine can be increased when it is combined with Ketoconazole.
KetoprofenThe metabolism of Ketoprofen can be decreased when combined with Quinine.
LabetalolQuinine may increase the hypotensive activities of Labetalol.
LacidipineQuinine may increase the hypotensive activities of Lacidipine.
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Quinine.
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Quinine.
LanreotideQuinine may increase the hypoglycemic activities of Lanreotide.
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Quinine.
LapatinibThe serum concentration of Quinine can be increased when it is combined with Lapatinib.
LapatinibThe metabolism of Lapatinib can be decreased when combined with Quinine.
LatanoprostQuinine may increase the hypotensive activities of Latanoprost.
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Quinine.
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Quinine.
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Quinine.
LenvatinibLenvatinib may increase the QTc-prolonging activities of Quinine.
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Quinine.
LercanidipineQuinine may increase the hypotensive activities of Lercanidipine.
LesinuradThe metabolism of Lesinurad can be decreased when combined with Quinine.
LeuprolideLeuprolide may increase the QTc-prolonging activities of Quinine.
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Quinine.
LevodopaThe metabolism of Levodopa can be decreased when combined with Quinine.
LevofloxacinLevofloxacin may increase the QTc-prolonging activities of Quinine.
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Quinine.
LevomilnacipranLevomilnacipran may increase the hypoglycemic activities of Quinine.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Quinine.
LevothyroxineThe serum concentration of Quinine can be decreased when it is combined with Levothyroxine.
LicofeloneThe metabolism of Licofelone can be decreased when combined with Quinine.
LidocaineThe serum concentration of Quinine can be increased when it is combined with Lidocaine.
LidocaineThe metabolism of Lidocaine can be decreased when combined with Quinine.
LinagliptinLinagliptin may increase the hypoglycemic activities of Quinine.
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Quinine.
LiothyronineThe serum concentration of Quinine can be decreased when it is combined with Liothyronine.
LiotrixThe serum concentration of Quinine can be decreased when it is combined with Liotrix.
LiraglutideLiraglutide may increase the hypoglycemic activities of Quinine.
LisinoprilQuinine may increase the hypotensive activities of Lisinopril.
LisinoprilThe serum concentration of Quinine can be increased when it is combined with Lisinopril.
LisurideThe metabolism of Lisuride can be decreased when combined with Quinine.
LithiumLithium may increase the QTc-prolonging activities of Quinine.
LofexidineQuinine may increase the hypotensive activities of Lofexidine.
LomitapideThe serum concentration of Quinine can be increased when it is combined with Lomitapide.
LomustineThe metabolism of Lomustine can be decreased when combined with Quinine.
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Quinine.
LopinavirThe serum concentration of Quinine can be decreased when it is combined with Lopinavir.
LopinavirQuinine may increase the QTc-prolonging activities of Lopinavir.
LoratadineThe serum concentration of Quinine can be increased when it is combined with Loratadine.
LoratadineThe metabolism of Loratadine can be decreased when combined with Quinine.
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Quinine.
LornoxicamThe metabolism of Lornoxicam can be decreased when combined with Quinine.
LosartanQuinine may increase the hypotensive activities of Losartan.
LosartanThe serum concentration of Quinine can be increased when it is combined with Losartan.
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Quinine.
LovastatinThe metabolism of Quinine can be decreased when combined with Lovastatin.
Lu AA21004Lu AA21004 may increase the hypoglycemic activities of Quinine.
LuliconazoleThe serum concentration of Quinine can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Quinine can be decreased when it is combined with Lumacaftor.
LumefantrineThe risk or severity of adverse effects can be increased when Quinine is combined with Lumefantrine.
LumefantrineLumefantrine may increase the QTc-prolonging activities of Quinine.
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Quinine.
MacitentanQuinine may increase the hypotensive activities of Macitentan.
MagaldrateThe serum concentration of Quinine can be decreased when it is combined with Magaldrate.
Magnesium carbonateThe serum concentration of Quinine can be decreased when it is combined with Magnesium carbonate.
Magnesium hydroxideThe serum concentration of Quinine can be decreased when it is combined with Magnesium hydroxide.
Magnesium oxideThe serum concentration of Quinine can be decreased when it is combined with Magnesium oxide.
Magnesium TrisilicateThe serum concentration of Quinine can be decreased when it is combined with Magnesium Trisilicate.
ManidipineQuinine may increase the hypotensive activities of Manidipine.
MannitolThe serum concentration of Mannitol can be increased when it is combined with Quinine.
MaprotilineThe serum concentration of Quinine can be increased when it is combined with Maprotiline.
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Quinine.
MebanazineMebanazine may increase the hypoglycemic activities of Quinine.
MebendazoleThe serum concentration of Quinine can be increased when it is combined with Mebendazole.
MecamylamineQuinine may increase the hypotensive activities of Mecamylamine.
MecaserminQuinine may increase the hypoglycemic activities of Mecasermin.
Mefenamic acidThe metabolism of Mefenamic acid can be decreased when combined with Quinine.
MefloquineThe risk or severity of adverse effects can be increased when Quinine is combined with Mefloquine.
MefloquineThe serum concentration of Quinine can be increased when it is combined with Mefloquine.
Megestrol acetateThe serum concentration of Quinine can be increased when it is combined with Megestrol acetate.
MelatoninThe metabolism of Melatonin can be decreased when combined with Quinine.
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Quinine.
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Quinine.
MeprobamateThe serum concentration of Quinine can be increased when it is combined with Meprobamate.
MequitazineThe metabolism of Mequitazine can be decreased when combined with Quinine.
MesalazineMesalazine may increase the hypoglycemic activities of Quinine.
MesoridazineThe serum concentration of Mesoridazine can be increased when it is combined with Quinine.
MestranolThe metabolism of Mestranol can be decreased when combined with Quinine.
MetforminMetformin may increase the hypoglycemic activities of Quinine.
MethadoneMethadone may increase the QTc-prolonging activities of Quinine.
MethadoneThe metabolism of Methadone can be decreased when combined with Quinine.
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Quinine.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Quinine.
MethotrimeprazineThe serum concentration of Methotrimeprazine can be increased when it is combined with Quinine.
MethotrimeprazineMethotrimeprazine may increase the QTc-prolonging activities of Quinine.
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Quinine.
MethyldopaQuinine may increase the hypotensive activities of Methyldopa.
Methylene blueThe serum concentration of Methylene blue can be increased when it is combined with Quinine.
Methylene blueMethylene blue may increase the hypoglycemic activities of Quinine.
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Quinine.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Quinine.
MethyltestosteroneMethyltestosterone may increase the hypoglycemic activities of Quinine.
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Quinine.
MetipranololQuinine may increase the hypotensive activities of Metipranolol.
MetoclopramideMetoclopramide may increase the QTc-prolonging activities of Quinine.
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Quinine.
MetolazoneQuinine may increase the hypotensive activities of Metolazone.
MetoprololQuinine may increase the hypotensive activities of Metoprolol.
MetoprololThe serum concentration of Quinine can be increased when it is combined with Metoprolol.
MetronidazoleMetronidazole may increase the QTc-prolonging activities of Quinine.
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Quinine.
MevastatinThe serum concentration of Mevastatin can be increased when it is combined with Quinine.
MexiletineThe metabolism of Quinine can be decreased when combined with Mexiletine.
MianserinThe metabolism of Mianserin can be decreased when combined with Quinine.
MibefradilQuinine may increase the hypotensive activities of Mibefradil.
MibefradilThe serum concentration of Quinine can be increased when it is combined with Mibefradil.
MiconazoleThe serum concentration of Quinine can be increased when it is combined with Miconazole.
MidazolamThe serum concentration of Quinine can be decreased when it is combined with Midazolam.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Quinine.
MifepristoneMifepristone may increase the QTc-prolonging activities of Quinine.
MiglitolMiglitol may increase the hypoglycemic activities of Quinine.
MiglustatMiglustat may increase the hypoglycemic activities of Quinine.
MilnacipranMilnacipran may increase the hypoglycemic activities of Quinine.
MinaprineMinaprine may increase the hypoglycemic activities of Quinine.
MinaprineThe metabolism of Minaprine can be decreased when combined with Quinine.
MinoxidilQuinine may increase the hypotensive activities of Minoxidil.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Quinine.
MirabegronThe metabolism of Quinine can be decreased when combined with Mirabegron.
MirtazapineMirtazapine may increase the QTc-prolonging activities of Quinine.
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Quinine.
MitiglinideMitiglinide may increase the hypoglycemic activities of Quinine.
MitomycinThe serum concentration of Quinine can be increased when it is combined with Mitomycin.
MitotaneThe serum concentration of Quinine can be decreased when it is combined with Mitotane.
MitoxantroneThe serum concentration of Quinine can be decreased when it is combined with Mitoxantrone.
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Quinine.
MoclobemideMoclobemide may increase the hypoglycemic activities of Quinine.
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Quinine.
ModafinilThe serum concentration of Quinine can be decreased when it is combined with Modafinil.
MoexiprilQuinine may increase the hypotensive activities of Moexipril.
MoexiprilMoexipril may increase the QTc-prolonging activities of Quinine.
MontelukastThe metabolism of Montelukast can be decreased when combined with Quinine.
MoricizineThe serum concentration of Moricizine can be increased when it is combined with Quinine.
MorphineThe serum concentration of Morphine can be increased when it is combined with Quinine.
MoxifloxacinMoxifloxacin may increase the QTc-prolonging activities of Quinine.
MoxonidineQuinine may increase the hypotensive activities of Moxonidine.
muraglitazarThe metabolism of muraglitazar can be decreased when combined with Quinine.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Quinine.
NadololQuinine may increase the hypotensive activities of Nadolol.
NafcillinThe serum concentration of Quinine can be decreased when it is combined with Nafcillin.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Quinine.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Quinine.
NaltrexoneThe serum concentration of Quinine can be increased when it is combined with Naltrexone.
NaproxenThe metabolism of Naproxen can be decreased when combined with Quinine.
NaringeninThe serum concentration of Quinine can be increased when it is combined with Naringenin.
NateglinideNateglinide may increase the hypoglycemic activities of Quinine.
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Quinine.
NefazodoneThe serum concentration of Quinine can be decreased when it is combined with Nefazodone.
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Quinine.
NelfinavirThe serum concentration of Quinine can be decreased when it is combined with Nelfinavir.
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Quinine.
NeostigmineThe serum concentration of Quinine can be increased when it is combined with Neostigmine.
NetupitantThe serum concentration of Quinine can be increased when it is combined with Netupitant.
NetupitantThe metabolism of Netupitant can be decreased when combined with Quinine.
NevirapineThe metabolism of Quinine can be decreased when combined with Nevirapine.
NialamideNialamide may increase the hypoglycemic activities of Quinine.
NicardipineQuinine may increase the hypotensive activities of Nicardipine.
NicardipineThe serum concentration of Quinine can be increased when it is combined with Nicardipine.
NicergolineThe metabolism of Nicergoline can be decreased when combined with Quinine.
NiclosamideThe metabolism of Niclosamide can be decreased when combined with Quinine.
NicorandilQuinine may increase the hypotensive activities of Nicorandil.
NicotineThe metabolism of Nicotine can be decreased when combined with Quinine.
NifedipineThe serum concentration of Quinine can be decreased when it is combined with Nifedipine.
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Quinine.
NiguldipineQuinine may increase the hypotensive activities of Niguldipine.
NilotinibQuinine may increase the QTc-prolonging activities of Nilotinib.
NilvadipineQuinine may increase the hypotensive activities of Nilvadipine.
NimodipineQuinine may increase the hypotensive activities of Nimodipine.
NintedanibThe serum concentration of Nintedanib can be decreased when it is combined with Quinine.
NisoldipineQuinine may increase the hypotensive activities of Nisoldipine.
NisoldipineThe serum concentration of Quinine can be increased when it is combined with Nisoldipine.
NitrazepamThe serum concentration of Quinine can be increased when it is combined with Nitrazepam.
NitrendipineQuinine may increase the hypotensive activities of Nitrendipine.
NitrendipineThe serum concentration of Quinine can be increased when it is combined with Nitrendipine.
Nitric OxideThe risk or severity of adverse effects can be increased when Nitric Oxide is combined with Quinine.
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Quinine.
NitroprussideQuinine may increase the hypotensive activities of Nitroprusside.
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Quinine.
NorethisteroneThe serum concentration of Quinine can be decreased when it is combined with Norethisterone.
NorfloxacinNorfloxacin may increase the QTc-prolonging activities of Quinine.
NortriptylineNortriptyline may increase the QTc-prolonging activities of Quinine.
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Quinine.
OctamoxinOctamoxin may increase the hypoglycemic activities of Quinine.
OctreotideOctreotide may increase the hypoglycemic activities of Quinine.
OfloxacinOfloxacin may increase the QTc-prolonging activities of Quinine.
OlanzapineOlanzapine may increase the hypoglycemic activities of Quinine.
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Quinine.
OlaparibThe metabolism of Quinine can be decreased when combined with Olaparib.
OlmesartanQuinine may increase the hypotensive activities of Olmesartan.
OlodaterolOlodaterol may increase the QTc-prolonging activities of Quinine.
OlodaterolThe metabolism of Olodaterol can be decreased when combined with Quinine.
OmapatrilatQuinine may increase the hypotensive activities of Omapatrilat.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Quinine.
OmeprazoleThe serum concentration of Quinine can be increased when it is combined with Omeprazole.
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Quinine.
OndansetronOndansetron may increase the QTc-prolonging activities of Quinine.
OndansetronThe metabolism of Ondansetron can be decreased when combined with Quinine.
OsimertinibThe serum concentration of Quinine can be increased when it is combined with Osimertinib.
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Quinine.
OxandroloneOxandrolone may increase the hypoglycemic activities of Quinine.
OxaprozinThe metabolism of Oxaprozin can be decreased when combined with Quinine.
OxprenololQuinine may increase the hypotensive activities of Oxprenolol.
OxycodoneThe metabolism of Oxycodone can be decreased when combined with Quinine.
OxymetholoneOxymetholone may increase the hypoglycemic activities of Quinine.
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Quinine.
OxytocinOxytocin may increase the QTc-prolonging activities of Quinine.
P-NitrophenolThe serum concentration of Quinine can be increased when it is combined with P-Nitrophenol.
PaclitaxelThe serum concentration of Quinine can be increased when it is combined with Paclitaxel.
PalbociclibThe serum concentration of Quinine can be increased when it is combined with Palbociclib.
PaliperidoneQuinine may increase the QTc-prolonging activities of Paliperidone.
Palmitic AcidThe serum concentration of Quinine can be increased when it is combined with Palmitic Acid.
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Quinine.
PanobinostatPanobinostat may increase the QTc-prolonging activities of Quinine.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Quinine.
PantoprazoleThe serum concentration of Quinine can be increased when it is combined with Pantoprazole.
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Quinine.
ParecoxibThe metabolism of Parecoxib can be decreased when combined with Quinine.
PargylineQuinine may increase the hypotensive activities of Pargyline.
PargylinePargyline may increase the hypoglycemic activities of Quinine.
ParoxetineParoxetine may increase the hypoglycemic activities of Quinine.
ParoxetineThe metabolism of Paroxetine can be decreased when combined with Quinine.
PasireotideQuinine may increase the hypoglycemic activities of Pasireotide.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Quinine.
PazopanibPazopanib may increase the QTc-prolonging activities of Quinine.
Peginterferon alfa-2bThe serum concentration of Quinine can be decreased when it is combined with Peginterferon alfa-2b.
PegvisomantPegvisomant may increase the hypoglycemic activities of Quinine.
PenbutololQuinine may increase the hypotensive activities of Penbutolol.
PentamidinePentamidine may increase the QTc-prolonging activities of Quinine.
PentamidineQuinine may increase the hypoglycemic activities of Pentamidine.
PentobarbitalThe metabolism of Quinine can be increased when combined with Pentobarbital.
PentoliniumQuinine may increase the hypotensive activities of Pentolinium.
PerflutrenPerflutren may increase the QTc-prolonging activities of Quinine.
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Quinine.
PerindoprilQuinine may increase the hypotensive activities of Perindopril.
PerindoprilThe serum concentration of Quinine can be increased when it is combined with Perindopril.
PerphenazineThe serum concentration of Perphenazine can be increased when it is combined with Quinine.
PethidineThe metabolism of Pethidine can be decreased when combined with Quinine.
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Quinine.
PhenelzinePhenelzine may increase the hypoglycemic activities of Quinine.
PhenforminPhenformin may increase the hypoglycemic activities of Quinine.
PhenforminThe metabolism of Phenformin can be decreased when combined with Quinine.
PhenindioneQuinine may increase the anticoagulant activities of Phenindione.
PheniprazinePheniprazine may increase the hypoglycemic activities of Quinine.
PhenobarbitalThe serum concentration of Quinine can be decreased when it is combined with Phenobarbital.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Quinine.
PhenoxybenzamineQuinine may increase the hypotensive activities of Phenoxybenzamine.
PhenoxypropazinePhenoxypropazine may increase the hypoglycemic activities of Quinine.
PhenprocoumonQuinine may increase the anticoagulant activities of Phenprocoumon.
PhentolamineQuinine may increase the hypotensive activities of Phentolamine.
PhenylbutazoneThe metabolism of Phenylbutazone can be decreased when combined with Quinine.
PhenytoinThe serum concentration of Quinine can be decreased when it is combined with Phenytoin.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Quinine.
PimozideQuinine may increase the QTc-prolonging activities of Pimozide.
PinacidilQuinine may increase the hypotensive activities of Pinacidil.
PindololQuinine may increase the hypotensive activities of Pindolol.
PioglitazonePioglitazone may increase the hypoglycemic activities of Quinine.
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Quinine.
PiperazineThe metabolism of Piperazine can be decreased when combined with Quinine.
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Quinine.
PirlindolePirlindole may increase the hypoglycemic activities of Quinine.
PiroxicamThe metabolism of Piroxicam can be decreased when combined with Quinine.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Quinine.
PivhydrazinePivhydrazine may increase the hypoglycemic activities of Quinine.
Platelet Activating FactorThe serum concentration of Quinine can be decreased when it is combined with Platelet Activating Factor.
PolythiazideQuinine may increase the hypotensive activities of Polythiazide.
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Quinine.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Quinine.
PosaconazoleThe serum concentration of Quinine can be increased when it is combined with Posaconazole.
PramlintidePramlintide may increase the hypoglycemic activities of Quinine.
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Quinine.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Quinine.
PrazosinQuinine may increase the hypotensive activities of Prazosin.
PrazosinThe serum concentration of Quinine can be increased when it is combined with Prazosin.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Quinine.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Quinine.
PrilocaineThe risk or severity of adverse effects can be increased when Quinine is combined with Prilocaine.
PrimaquinePrimaquine may increase the QTc-prolonging activities of Quinine.
PrimidoneThe metabolism of Quinine can be increased when combined with Primidone.
ProbenecidThe serum concentration of Quinine can be increased when it is combined with Probenecid.
ProcainamideQuinine may increase the QTc-prolonging activities of Procainamide.
ProchlorperazineThe serum concentration of Prochlorperazine can be increased when it is combined with Quinine.
ProgesteroneThe serum concentration of Quinine can be decreased when it is combined with Progesterone.
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Quinine.
ProguanilThe metabolism of Proguanil can be decreased when combined with Quinine.
PromazineThe serum concentration of Promazine can be increased when it is combined with Quinine.
PromazinePromazine may increase the QTc-prolonging activities of Quinine.
PromethazineThe serum concentration of Promethazine can be increased when it is combined with Quinine.
PropafenonePropafenone may increase the QTc-prolonging activities of Quinine.
PropafenoneThe metabolism of Propafenone can be decreased when combined with Quinine.
PropofolPropofol may increase the QTc-prolonging activities of Quinine.
PropofolThe metabolism of Propofol can be decreased when combined with Quinine.
PropranololQuinine may increase the hypotensive activities of Propranolol.
PropranololThe serum concentration of Quinine can be increased when it is combined with Propranolol.
ProtriptylineThe serum concentration of Quinine can be increased when it is combined with Protriptyline.
ProtriptylineThe metabolism of Protriptyline can be decreased when combined with Quinine.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Quinine.
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Quinine.
PyrimethamineThe metabolism of Quinine can be decreased when combined with Pyrimethamine.
QuazepamThe metabolism of Quazepam can be decreased when combined with Quinine.
QuercetinThe serum concentration of Quinine can be increased when it is combined with Quercetin.
QuetiapineQuinine may increase the QTc-prolonging activities of Quetiapine.
QuinacrineThe serum concentration of Quinine can be increased when it is combined with Quinacrine.
QuinaprilQuinine may increase the hypotensive activities of Quinapril.
QuinidineQuinine may increase the QTc-prolonging activities of Quinidine.
RabeprazoleThe metabolism of Quinine can be decreased when combined with Rabeprazole.
RamiprilQuinine may increase the hypotensive activities of Ramipril.
RanitidineThe serum concentration of Quinine can be increased when it is combined with Ranitidine.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Quinine.
RasagilineRasagiline may increase the hypoglycemic activities of Quinine.
ReboxetineThe serum concentration of Quinine can be increased when it is combined with Reboxetine.
RegorafenibThe serum concentration of Quinine can be increased when it is combined with Regorafenib.
RemikirenQuinine may increase the hypotensive activities of Remikiren.
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Quinine.
RepaglinideRepaglinide may increase the hypoglycemic activities of Quinine.
repinotanThe metabolism of repinotan can be decreased when combined with Quinine.
RescinnamineQuinine may increase the hypotensive activities of Rescinnamine.
ReserpineQuinine may increase the hypotensive activities of Reserpine.
ReserpineThe serum concentration of Quinine can be decreased when it is combined with Reserpine.
RifabutinThe metabolism of Quinine can be increased when combined with Rifabutin.
RifampicinThe serum concentration of Quinine can be decreased when it is combined with Rifampicin.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Quinine.
RifapentineThe metabolism of Quinine can be increased when combined with Rifapentine.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Quinine.
RilpivirineThe serum concentration of Quinine can be increased when it is combined with Rilpivirine.
RiociguatQuinine may increase the hypotensive activities of Riociguat.
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Quinine.
RisperidoneRisperidone may increase the QTc-prolonging activities of Quinine.
RitonavirThe serum concentration of Quinine can be decreased when it is combined with Ritonavir.
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Quinine.
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Quinine.
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Quinine.
RolapitantThe serum concentration of Quinine can be increased when it is combined with Rolapitant.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Quinine.
RopiniroleThe metabolism of Quinine can be decreased when combined with Ropinirole.
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Quinine.
RosiglitazoneRosiglitazone may increase the hypoglycemic activities of Quinine.
RosiglitazoneThe metabolism of Rosiglitazone can be decreased when combined with Quinine.
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Quinine.
RotigotineThe metabolism of Rotigotine can be decreased when combined with Quinine.
SafrazineSafrazine may increase the hypoglycemic activities of Quinine.
SalbutamolSalbutamol may increase the QTc-prolonging activities of Quinine.
Salicylic acidSalicylic acid may increase the hypoglycemic activities of Quinine.
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Quinine.
SalmeterolSalmeterol may increase the QTc-prolonging activities of Quinine.
SaprisartanQuinine may increase the hypotensive activities of Saprisartan.
SaquinavirSaquinavir may increase the QTc-prolonging activities of Quinine.
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Quinine.
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Quinine.
SaxagliptinSaxagliptin may increase the hypoglycemic activities of Quinine.
ScopolamineThe serum concentration of Quinine can be increased when it is combined with Scopolamine.
SecobarbitalThe metabolism of Quinine can be increased when combined with Secobarbital.
SelegilineSelegiline may increase the hypoglycemic activities of Quinine.
SelegilineThe metabolism of Selegiline can be decreased when combined with Quinine.
SelexipagQuinine may increase the hypotensive activities of Selexipag.
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Quinine.
SertindoleThe metabolism of Sertindole can be decreased when combined with Quinine.
SertralineSertraline may increase the hypoglycemic activities of Quinine.
SertralineThe metabolism of Sertraline can be decreased when combined with Quinine.
SevofluraneSevoflurane may increase the QTc-prolonging activities of Quinine.
SildenafilThe metabolism of Quinine can be decreased when combined with Sildenafil.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Quinine.
SiltuximabThe serum concentration of Quinine can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Quinine can be increased when it is combined with Simeprevir.
SimvastatinThe serum concentration of Quinine can be increased when it is combined with Simvastatin.
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Quinine.
SirolimusThe serum concentration of Quinine can be decreased when it is combined with Sirolimus.
SitagliptinSitagliptin may increase the hypoglycemic activities of Quinine.
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Quinine.
SitaxentanQuinine may increase the hypotensive activities of Sitaxentan.
Sodium NitriteThe risk or severity of adverse effects can be increased when Quinine is combined with Sodium Nitrite.
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Quinine.
SolifenacinSolifenacin may increase the QTc-prolonging activities of Quinine.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Quinine.
SotalolQuinine may increase the QTc-prolonging activities of Sotalol.
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Quinine.
SparteineThe metabolism of Sparteine can be decreased when combined with Quinine.
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Quinine.
SpiraprilQuinine may increase the hypotensive activities of Spirapril.
SpironolactoneThe serum concentration of Quinine can be increased when it is combined with Spironolactone.
St. John's WortThe serum concentration of Quinine can be decreased when it is combined with St. John's Wort.
StanozololStanozolol may increase the hypoglycemic activities of Quinine.
StaurosporineThe serum concentration of Quinine can be increased when it is combined with Staurosporine.
StiripentolThe serum concentration of Quinine can be increased when it is combined with Stiripentol.
StreptozocinThe serum concentration of Quinine can be decreased when it is combined with Streptozocin.
SulfadiazineSulfadiazine may increase the hypoglycemic activities of Quinine.
SulfamethoxazoleQuinine may increase the hypoglycemic activities of Sulfamethoxazole.
SulfamoxoleThe metabolism of Sulfamoxole can be decreased when combined with Quinine.
SulfinpyrazoneThe serum concentration of Quinine can be increased when it is combined with Sulfinpyrazone.
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Quinine.
SulfisoxazoleSulfisoxazole may increase the QTc-prolonging activities of Quinine.
SulfisoxazoleQuinine may increase the hypoglycemic activities of Sulfisoxazole.
SulodexideSulodexide may increase the hypoglycemic activities of Quinine.
SumatriptanThe serum concentration of Quinine can be increased when it is combined with Sumatriptan.
SunitinibQuinine may increase the hypoglycemic activities of Sunitinib.
SuprofenThe metabolism of Suprofen can be decreased when combined with Quinine.
TacrineThe serum concentration of Quinine can be increased when it is combined with Tacrine.
TacrolimusThe serum concentration of Quinine can be decreased when it is combined with Tacrolimus.
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Quinine.
TamoxifenThe serum concentration of Quinine can be decreased when it is combined with Tamoxifen.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Quinine.
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Quinine.
TapentadolThe metabolism of Tapentadol can be decreased when combined with Quinine.
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Quinine.
TazaroteneThe metabolism of Tazarotene can be decreased when combined with Quinine.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Quinine.
TegaserodThe metabolism of Tegaserod can be decreased when combined with Quinine.
TelaprevirThe metabolism of Quinine can be decreased when combined with Telaprevir.
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Quinine.
TelavancinTelavancin may increase the QTc-prolonging activities of Quinine.
TelithromycinTelithromycin may increase the QTc-prolonging activities of Quinine.
TelmisartanQuinine may increase the hypotensive activities of Telmisartan.
TelmisartanThe serum concentration of Quinine can be increased when it is combined with Telmisartan.
TemazepamThe metabolism of Temazepam can be decreased when combined with Quinine.
TemocaprilQuinine may increase the hypotensive activities of Temocapril.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Quinine.
TenofovirThe metabolism of Quinine can be decreased when combined with Tenofovir.
TenoxicamThe metabolism of Tenoxicam can be decreased when combined with Quinine.
TerazosinThe serum concentration of Quinine can be increased when it is combined with Terazosin.
TerbinafineThe metabolism of Quinine can be decreased when combined with Terbinafine.
TerbutalineTerbutaline may increase the QTc-prolonging activities of Quinine.
TerfenadineThe serum concentration of Quinine can be increased when it is combined with Terfenadine.
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Quinine.
TeriflunomideThe serum concentration of Quinine can be decreased when it is combined with Teriflunomide.
TerlipressinQuinine may increase the hypotensive activities of Terlipressin.
TesmilifeneThe serum concentration of Quinine can be decreased when it is combined with Tesmilifene.
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Quinine.
TestosteroneTestosterone may increase the hypoglycemic activities of Quinine.
TestosteroneThe metabolism of Testosterone can be decreased when combined with Quinine.
TetrabenazineQuinine may increase the QTc-prolonging activities of Tetrabenazine.
TetracyclineThe serum concentration of Quinine can be increased when it is combined with Tetracycline.
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Quinine.
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Quinine.
TheophyllineThe metabolism of Quinine can be decreased when combined with Theophylline.
ThiamylalThe metabolism of Thiamylal can be decreased when combined with Quinine.
ThiethylperazineThe serum concentration of Thiethylperazine can be increased when it is combined with Quinine.
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Quinine.
ThioridazineThioridazine may increase the QTc-prolonging activities of Quinine.
ThiothixeneThiothixene may increase the QTc-prolonging activities of Quinine.
TiboloneQuinine may increase the hypotensive activities of Tibolone.
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Quinine.
TiclopidineThe metabolism of Quinine can be decreased when combined with Ticlopidine.
TicrynafenQuinine may increase the hypotensive activities of Ticrynafen.
TimololQuinine may increase the hypotensive activities of Timolol.
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Quinine.
TipranavirThe metabolism of Tipranavir can be decreased when combined with Quinine.
TizanidineTizanidine may increase the QTc-prolonging activities of Quinine.
TocilizumabThe serum concentration of Quinine can be decreased when it is combined with Tocilizumab.
TolazamideTolazamide may increase the hypoglycemic activities of Quinine.
TolazolineQuinine may increase the hypotensive activities of Tolazoline.
TolbutamideTolbutamide may increase the hypoglycemic activities of Quinine.
ToloxatoneToloxatone may increase the hypoglycemic activities of Quinine.
TolterodineTolterodine may increase the QTc-prolonging activities of Quinine.
TolterodineThe metabolism of Tolterodine can be decreased when combined with Quinine.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Quinine.
TopiramateThe metabolism of Quinine can be decreased when combined with Topiramate.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Quinine.
TorasemideQuinine may increase the hypotensive activities of Torasemide.
ToremifeneQuinine may increase the QTc-prolonging activities of Toremifene.
TrabectedinThe metabolism of Trabectedin can be decreased when combined with Quinine.
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Quinine.
TrandolaprilQuinine may increase the hypotensive activities of Trandolapril.
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the hypoglycemic activities of Quinine.
TranylcypromineTranylcypromine may increase the hypoglycemic activities of Quinine.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Quinine.
TravoprostQuinine may increase the hypotensive activities of Travoprost.
TrazodoneTrazodone may increase the hypoglycemic activities of Quinine.
TrazodoneThe metabolism of Trazodone can be decreased when combined with Quinine.
TreprostinilQuinine may increase the hypotensive activities of Treprostinil.
TreprostinilTreprostinil may increase the QTc-prolonging activities of Quinine.
TretinoinThe metabolism of Tretinoin can be decreased when combined with Quinine.
TrichlormethiazideQuinine may increase the hypotensive activities of Trichlormethiazide.
TrifluoperazineThe serum concentration of Trifluoperazine can be increased when it is combined with Quinine.
TriflupromazineThe serum concentration of Triflupromazine can be increased when it is combined with Quinine.
TrimazosinQuinine may increase the hypotensive activities of Trimazosin.
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Quinine.
TrimethaphanQuinine may increase the hypotensive activities of Trimethaphan.
TrimethoprimThe serum concentration of Quinine can be decreased when it is combined with Trimethoprim.
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Quinine.
TrimipramineThe serum concentration of Quinine can be increased when it is combined with Trimipramine.
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Quinine.
TriptorelinTriptorelin may increase the QTc-prolonging activities of Quinine.
TroglitazoneTroglitazone may increase the hypoglycemic activities of Quinine.
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Quinine.
TroleandomycinThe serum concentration of Quinine can be increased when it is combined with Troleandomycin.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Quinine.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Quinine.
UnoprostoneQuinine may increase the hypotensive activities of Unoprostone.
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Quinine.
Valproic AcidThe metabolism of Quinine can be decreased when combined with Valproic Acid.
ValsartanQuinine may increase the hypotensive activities of Valsartan.
ValsartanThe metabolism of Quinine can be decreased when combined with Valsartan.
VandetanibQuinine may increase the QTc-prolonging activities of Vandetanib.
VardenafilVardenafil may increase the QTc-prolonging activities of Quinine.
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Quinine.
VemurafenibQuinine may increase the QTc-prolonging activities of Vemurafenib.
VenlafaxineThe metabolism of Quinine can be decreased when combined with Venlafaxine.
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Quinine.
VerapamilThe metabolism of Quinine can be decreased when combined with Verapamil.
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Quinine.
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Quinine.
VilanterolVilanterol may increase the QTc-prolonging activities of Quinine.
VilazodoneVilazodone may increase the hypoglycemic activities of Quinine.
VilazodoneThe metabolism of Vilazodone can be decreased when combined with Quinine.
VildagliptinVildagliptin may increase the hypoglycemic activities of Quinine.
VinblastineThe serum concentration of Quinine can be decreased when it is combined with Vinblastine.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Quinine.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Quinine.
VincristineThe serum concentration of Quinine can be decreased when it is combined with Vincristine.
VinorelbineThe serum concentration of Quinine can be increased when it is combined with Vinorelbine.
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Quinine.
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Quinine.
VogliboseVoglibose may increase the hypoglycemic activities of Quinine.
VoriconazoleThe metabolism of Quinine can be decreased when combined with Voriconazole.
VorinostatVorinostat may increase the QTc-prolonging activities of Quinine.
VortioxetineVortioxetine may increase the hypoglycemic activities of Quinine.
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Quinine.
WarfarinQuinine may increase the anticoagulant activities of Warfarin.
XimelagatranThe metabolism of Ximelagatran can be decreased when combined with Quinine.
XylometazolineQuinine may increase the hypotensive activities of Xylometazoline.
YohimbineThe metabolism of Yohimbine can be decreased when combined with Quinine.
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Quinine.
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Quinine.
ZaltoprofenThe metabolism of Zaltoprofen can be decreased when combined with Quinine.
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Quinine.
ZileutonThe metabolism of Zileuton can be decreased when combined with Quinine.
ZimelidineZimelidine may increase the hypoglycemic activities of Quinine.
ZiprasidoneZiprasidone may increase the QTc-prolonging activities of Quinine.
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Quinine.
ZopicloneThe metabolism of Zopiclone can be decreased when combined with Quinine.
ZuclopenthixolQuinine may increase the QTc-prolonging activities of Zuclopenthixol.
Food Interactions
  • Take with food to reduce irritation.

Targets

1. Fe(II)-protoporphyrin IX
Kind
Small molecule
Organism
Plasmodium falciparum
Pharmacological action
yes
Actions
antagonist
References
  1. Alumasa JN, Gorka AP, Casabianca LB, Comstock E, de Dios AC, Roepe PD: The hydroxyl functionality and a rigid proximal N are required for forming a novel non-covalent quinine-heme complex. J Inorg Biochem. 2011 Mar;105(3):467-75. doi: 10.1016/j.jinorgbio.2010.08.011. Epub 2010 Sep 22. [PubMed:20864177 ]
  2. Fitch CD: Ferriprotoporphyrin IX, phospholipids, and the antimalarial actions of quinoline drugs. Life Sci. 2004 Mar 5;74(16):1957-72. [PubMed:14967191 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
other
General Function:
Not Available
Specific Function:
The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib.
Gene Name:
GP9
Uniprot ID:
P14770
Molecular Weight:
19045.87 Da
References
  1. Asvadi P, Ahmadi Z, Chong BH: Drug-induced thrombocytopenia: localization of the binding site of GPIX-specific quinine-dependent antibodies. Blood. 2003 Sep 1;102(5):1670-7. Epub 2003 May 8. [PubMed:12738668 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Protein phosphatase binding
Specific Function:
Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin (PubMed:17157250, PubMe...
Gene Name:
KCNN4
Uniprot ID:
O15554
Molecular Weight:
47695.12 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitorinducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Zhao XJ, Yokoyama H, Chiba K, Wanwimolruk S, Ishizaki T: Identification of human cytochrome P450 isoforms involved in the 3-hydroxylation of quinine by human live microsomes and nine recombinant human cytochromes P450. J Pharmacol Exp Ther. 1996 Dec;279(3):1327-34. [PubMed:8968357 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Ekins S, Bravi G, Wikel JH, Wrighton SA: Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates. J Pharmacol Exp Ther. 1999 Oct;291(1):424-33. [PubMed:10490933 ]
  4. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Vitamin d 24-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP1A1
Uniprot ID:
P04798
Molecular Weight:
58164.815 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitorinducer
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Zhao XJ, Yokoyama H, Chiba K, Wanwimolruk S, Ishizaki T: Identification of human cytochrome P450 isoforms involved in the 3-hydroxylation of quinine by human live microsomes and nine recombinant human cytochromes P450. J Pharmacol Exp Ther. 1996 Dec;279(3):1327-34. [PubMed:8968357 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. [PubMed:11159893 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular Weight:
56848.42 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Quaternary ammonium group transmembrane transporter activity
Specific Function:
Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridiniu...
Gene Name:
SLC22A2
Uniprot ID:
O15244
Molecular Weight:
62579.99 Da
References
  1. Sweet DH, Miller DS, Pritchard JB: Ventricular choline transport: a role for organic cation transporter 2 expressed in choroid plexus. J Biol Chem. 2001 Nov 9;276(45):41611-9. Epub 2001 Sep 11. [PubMed:11553644 ]
  2. Gorboulev V, Ulzheimer JC, Akhoundova A, Ulzheimer-Teuber I, Karbach U, Quester S, Baumann C, Lang F, Busch AE, Koepsell H: Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol. 1997 Jul;16(7):871-81. [PubMed:9260930 ]
  3. Kakehi M, Koyabu N, Nakamura T, Uchiumi T, Kuwano M, Ohtani H, Sawada Y: Functional characterization of mouse cation transporter mOCT2 compared with mOCT1. Biochem Biophys Res Commun. 2002 Aug 23;296(3):644-50. [PubMed:12176030 ]
  4. Arndt P, Volk C, Gorboulev V, Budiman T, Popp C, Ulzheimer-Teuber I, Akhoundova A, Koppatz S, Bamberg E, Nagel G, Koepsell H: Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1. Am J Physiol Renal Physiol. 2001 Sep;281(3):F454-68. [PubMed:11502595 ]
  5. Goralski KB, Lou G, Prowse MT, Gorboulev V, Volk C, Koepsell H, Sitar DS: The cation transporters rOCT1 and rOCT2 interact with bicarbonate but play only a minor role for amantadine uptake into rat renal proximal tubules. J Pharmacol Exp Ther. 2002 Dec;303(3):959-68. [PubMed:12438515 ]
  6. Sweet DH, Pritchard JB: rOCT2 is a basolateral potential-driven carrier, not an organic cation/proton exchanger. Am J Physiol. 1999 Dec;277(6 Pt 2):F890-8. [PubMed:10600936 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Secondary active organic cation transmembrane transporter activity
Specific Function:
Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine...
Gene Name:
SLC22A1
Uniprot ID:
O15245
Molecular Weight:
61153.345 Da
References
  1. Zhang L, Dresser MJ, Gray AT, Yost SC, Terashita S, Giacomini KM: Cloning and functional expression of a human liver organic cation transporter. Mol Pharmacol. 1997 Jun;51(6):913-21. [PubMed:9187257 ]
  2. Zhang L, Schaner ME, Giacomini KM: Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). J Pharmacol Exp Ther. 1998 Jul;286(1):354-61. [PubMed:9655880 ]
  3. Kakehi M, Koyabu N, Nakamura T, Uchiumi T, Kuwano M, Ohtani H, Sawada Y: Functional characterization of mouse cation transporter mOCT2 compared with mOCT1. Biochem Biophys Res Commun. 2002 Aug 23;296(3):644-50. [PubMed:12176030 ]
  4. Arndt P, Volk C, Gorboulev V, Budiman T, Popp C, Ulzheimer-Teuber I, Akhoundova A, Koppatz S, Bamberg E, Nagel G, Koepsell H: Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1. Am J Physiol Renal Physiol. 2001 Sep;281(3):F454-68. [PubMed:11502595 ]
  5. Sweet DH, Miller DS, Pritchard JB: Ventricular choline transport: a role for organic cation transporter 2 expressed in choroid plexus. J Biol Chem. 2001 Nov 9;276(45):41611-9. Epub 2001 Sep 11. [PubMed:11553644 ]
  6. Goralski KB, Lou G, Prowse MT, Gorboulev V, Volk C, Koepsell H, Sitar DS: The cation transporters rOCT1 and rOCT2 interact with bicarbonate but play only a minor role for amantadine uptake into rat renal proximal tubules. J Pharmacol Exp Ther. 2002 Dec;303(3):959-68. [PubMed:12438515 ]
  7. Grundemann D, Gorboulev V, Gambaryan S, Veyhl M, Koepsell H: Drug excretion mediated by a new prototype of polyspecific transporter. Nature. 1994 Dec 8;372(6506):549-52. [PubMed:7990927 ]
  8. Martel F, Vetter T, Russ H, Grundemann D, Azevedo I, Koepsell H, Schomig E: Transport of small organic cations in the rat liver. The role of the organic cation transporter OCT1. Naunyn Schmiedebergs Arch Pharmacol. 1996 Aug-Sep;354(3):320-6. [PubMed:8878062 ]
  9. Busch AE, Quester S, Ulzheimer JC, Gorboulev V, Akhoundova A, Waldegger S, Lang F, Koepsell H: Monoamine neurotransmitter transport mediated by the polyspecific cation transporter rOCT1. FEBS Lett. 1996 Oct 21;395(2-3):153-6. [PubMed:8898084 ]
  10. Busch AE, Quester S, Ulzheimer JC, Waldegger S, Gorboulev V, Arndt P, Lang F, Koepsell H: Electrogenic properties and substrate specificity of the polyspecific rat cation transporter rOCT1. J Biol Chem. 1996 Dec 20;271(51):32599-604. [PubMed:8955087 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Symporter activity
Specific Function:
Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.
Gene Name:
SLC22A5
Uniprot ID:
O76082
Molecular Weight:
62751.08 Da
References
  1. Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A: Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. [PubMed:10525100 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. [PubMed:11716514 ]
  2. van der Sandt IC, Blom-Roosemalen MC, de Boer AG, Breimer DD: Specificity of doxorubicin versus rhodamine-123 in assessing P-glycoprotein functionality in the LLC-PK1, LLC-PK1:MDR1 and Caco-2 cell lines. Eur J Pharm Sci. 2000 Sep;11(3):207-14. [PubMed:11042226 ]
  3. Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. [PubMed:14985103 ]
  4. Borgnia MJ, Eytan GD, Assaraf YG: Competition of hydrophobic peptides, cytotoxic drugs, and chemosensitizers on a common P-glycoprotein pharmacophore as revealed by its ATPase activity. J Biol Chem. 1996 Feb 9;271(6):3163-71. [PubMed:8621716 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. Shitara Y, Sugiyama D, Kusuhara H, Kato Y, Abe T, Meier PJ, Itoh T, Sugiyama Y: Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport. Pharm Res. 2002 Feb;19(2):147-53. [PubMed:11883641 ]
  2. Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. [PubMed:11159893 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Symporter activity
Specific Function:
Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET).
Gene Name:
SLC22A4
Uniprot ID:
Q9H015
Molecular Weight:
62154.48 Da
References
  1. Yabuuchi H, Tamai I, Nezu J, Sakamoto K, Oku A, Shimane M, Sai Y, Tsuji A: Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 1999 May;289(2):768-73. [PubMed:10215651 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23