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Identification
NameEnalapril
Accession NumberDB00584  (APRD00510)
TypeSmall Molecule
GroupsApproved, Vet Approved
DescriptionEnalapril is a prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to enalaprilat following oral administration. Enalaprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Enalapril may be used to treat essential or renovascular hypertension and symptomatic congestive heart failure.
Structure
Thumb
Synonyms
(S)-1-(N-(1-(Ethoxycarbonyl)-3-phenylpropyl)-L-alanyl)-L-proline
(S)-1-{(S)-2-[1-((S)-ethoxycarbonyl)-3-phenyl-propylamino]-propionyl}-pyrrolidine-2-carboxylic acid
1-(N-((S)-1-Carboxy-3-phenylpropyl)-L-alanyl)-L-proline 1'-ethyl ester
Analapril
Enalapril
Enalaprila
Enalaprilum
External Identifiers
  • L 154739-01 D
  • MK 421
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Act Enalapriltablet16 mgoralActavis Pharma Company2007-10-17Not applicableCanada
Act Enalapriltablet2 mgoralActavis Pharma Company2007-10-17Not applicableCanada
Act Enalapriltablet4 mgoralActavis Pharma Company2007-10-17Not applicableCanada
Act Enalapriltablet8 mgoralActavis Pharma Company2007-10-17Not applicableCanada
Ava-enalapriltablet20.0 mgoralAvanstra Inc2011-10-112014-08-21Canada
Ava-enalapriltablet2.5 mgoralAvanstra Inc2011-10-112014-08-21Canada
Ava-enalapriltablet5.0 mgoralAvanstra Inc2011-10-112014-08-21Canada
Ava-enalapriltablet10.0 mgoralAvanstra Inc2011-10-112014-08-21Canada
Dom-enalapriltablet16 mgoralDominion PharmacalNot applicableNot applicableCanada
Dom-enalapriltablet2.0 mgoralDominion PharmacalNot applicableNot applicableCanada
Dom-enalapriltablet4 mgoralDominion PharmacalNot applicableNot applicableCanada
Dom-enalapriltablet8 mgoralDominion PharmacalNot applicableNot applicableCanada
Enalapriltablet8 mgoralSanis Health Inc2013-02-13Not applicableCanada
Enalapriltablet8.0 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Enalapriltablet4 mgoralFrosst A Division Of Merck Canada IncNot applicableNot applicableCanada
Enalapriltablet8 mgoralSivem Pharmaceuticals Ulc2015-08-10Not applicableCanada
Enalapriltablet16 mgoralSanis Health Inc2013-02-13Not applicableCanada
Enalapriltablet16 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Enalapriltablet8 mgoralFrosst A Division Of Merck Canada IncNot applicableNot applicableCanada
Enalapriltablet16 mgoralSivem Pharmaceuticals Ulc2015-08-10Not applicableCanada
Enalapriltablet2.0 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Enalapriltablet2 mgoralSivem Pharmaceuticals Ulc2015-08-10Not applicableCanada
Enalapriltablet2 mgoralSanis Health Inc2013-02-13Not applicableCanada
Enalapriltablet16 mgoralFrosst A Division Of Merck Canada IncNot applicableNot applicableCanada
Enalapriltablet4.0 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Enalapriltablet2 mgoralFrosst A Division Of Merck Canada IncNot applicableNot applicableCanada
Enalapriltablet4 mgoralSivem Pharmaceuticals Ulc2015-08-10Not applicableCanada
Enalapriltablet4 mgoralSanis Health Inc2013-02-13Not applicableCanada
Enalapril Maleatetablet20 mg/1oralOceanside Pharmaceuticals1985-12-24Not applicableUs
Enalapril Maleatetablet2.5 mg/1oralOceanside Pharmaceuticals1988-07-26Not applicableUs
Enalapril Maleatetablet5 mg/1oralOceanside Pharmaceuticals1985-12-24Not applicableUs
Enalapril Maleatetablet10 mg/1oralOceanside Pharmaceuticals1985-12-24Not applicableUs
EpanedkitSilvergate Pharmaceuticals, Inc.2013-08-22Not applicableUs
Mar-enalapriltablet10 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Mar-enalapriltablet20 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Mylan-enalapriltablet8 mgoralMylan Pharmaceuticals Ulc2007-10-17Not applicableCanada
Mylan-enalapriltablet16 mgoralMylan Pharmaceuticals Ulc2007-10-17Not applicableCanada
Mylan-enalapriltablet2 mgoralMylan Pharmaceuticals Ulc2007-10-17Not applicableCanada
Mylan-enalapriltablet4 mgoralMylan Pharmaceuticals Ulc2007-10-17Not applicableCanada
Ntp-enalapriltablet8 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-enalapriltablet16 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-enalapriltablet32 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-enalapriltablet2 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-enalapriltablet4 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Nu-enalapriltablet10 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-enalapriltablet20 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-enalapriltablet2.5 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-enalapriltablet5 mgoralNu Pharm IncNot applicableNot applicableCanada
PMS-enalapriltablet8 mgoralPharmascience Inc2007-11-23Not applicableCanada
PMS-enalapriltablet16 mgoralPharmascience Inc2007-11-23Not applicableCanada
PMS-enalapriltablet2.0 mgoralPharmascience Inc2007-11-23Not applicableCanada
PMS-enalapriltablet4 mgoralPharmascience Inc2007-11-23Not applicableCanada
Pro-enalapril - 10tablet10 mgoralPro Doc Limitee2008-07-04Not applicableCanada
Pro-enalapril - 2.5tablet2.5 mgoralPro Doc Limitee2008-07-04Not applicableCanada
Pro-enalapril - 20tablet20 mgoralPro Doc Limitee2008-07-04Not applicableCanada
Pro-enalapril - 5tablet5 mgoralPro Doc Limitee2008-07-04Not applicableCanada
Ran-enalapriltablet2 mgoralRanbaxy Pharmaceuticals Canada Inc.2010-08-01Not applicableCanada
Ran-enalapriltablet4 mgoralRanbaxy Pharmaceuticals Canada Inc.2010-08-01Not applicableCanada
Ran-enalapriltablet8 mgoralRanbaxy Pharmaceuticals Canada Inc.2010-08-01Not applicableCanada
Ran-enalapriltablet16 mgoralRanbaxy Pharmaceuticals Canada Inc.2010-08-01Not applicableCanada
Ratio-enalapriltablet16 mgoralRatiopharm Inc Division Of Teva Canada Limited2007-10-172014-09-19Canada
Ratio-enalapriltablet2.0 mgoralRatiopharm Inc Division Of Teva Canada Limited2007-10-172014-09-19Canada
Ratio-enalapriltablet4.0 mgoralRatiopharm Inc Division Of Teva Canada Limited2007-10-172014-09-19Canada
Ratio-enalapriltablet8.0 mgoralRatiopharm Inc Division Of Teva Canada Limited2007-10-172014-09-19Canada
Riva-enalapriltablet4.0 mgoralLaboratoire Riva Inc2007-10-20Not applicableCanada
Riva-enalapriltablet8.0 mgoralLaboratoire Riva Inc2007-10-20Not applicableCanada
Riva-enalapriltablet16 mgoralLaboratoire Riva Inc2007-10-20Not applicableCanada
Riva-enalapriltablet2.0 mgoralLaboratoire Riva Inc2007-10-20Not applicableCanada
Sandoz Enalapriltablet8.0 mgoralSandoz Canada Incorporated2007-10-17Not applicableCanada
Sandoz Enalapriltablet16 mgoralSandoz Canada Incorporated2007-10-17Not applicableCanada
Sandoz Enalapriltablet2.0 mgoralSandoz Canada Incorporated2007-10-17Not applicableCanada
Sandoz Enalapriltablet4.0 mgoralSandoz Canada Incorporated2007-10-17Not applicableCanada
Sig-enalapriltablet16 mgoralSigmacon Lifesciences Inc2009-04-302015-08-02Canada
Sig-enalapriltablet2.0 mgoralSigmacon Lifesciences Inc2009-04-302015-08-02Canada
Sig-enalapriltablet4.0 mgoralSigmacon Lifesciences Inc2009-04-302015-08-02Canada
Sig-enalapriltablet8.0 mgoralSigmacon Lifesciences Inc2009-04-302015-08-02Canada
Taro-enalapriltablet8 mgoralTaro Pharmaceuticals Inc2007-11-06Not applicableCanada
Taro-enalapriltablet16 mgoralTaro Pharmaceuticals Inc2007-11-06Not applicableCanada
Taro-enalapriltablet2.0 mgoralTaro Pharmaceuticals Inc2007-11-06Not applicableCanada
Taro-enalapriltablet4 mgoralTaro Pharmaceuticals Inc2007-11-06Not applicableCanada
Teva-enalapriltablet16 mgoralTeva Canada Limited2007-10-17Not applicableCanada
Teva-enalapriltablet2.0 mgoralTeva Canada Limited2007-10-17Not applicableCanada
Teva-enalapriltablet4 mgoralTeva Canada Limited1998-08-31Not applicableCanada
Teva-enalapriltablet32 mgoralTeva Canada Limited2009-09-15Not applicableCanada
Teva-enalapriltablet8 mgoralTeva Canada Limited1998-08-31Not applicableCanada
Vasotectablet5 mg/1oralREMEDYREPACK INC.2015-02-25Not applicableUs
Vasotectablet2.5 mg/1oralValeant Pharmaceuticals North America LLC1988-07-26Not applicableUs
Vasotectablet8 mgoralMerck Canada Inc1987-12-31Not applicableCanada
Vasotectablet5 mg/1oralValeant Pharmaceuticals North America LLC1985-12-24Not applicableUs
Vasotectablet2 mgoralMerck Canada Inc1990-12-31Not applicableCanada
Vasotectablet16 mgoralMerck Canada Inc1987-12-31Not applicableCanada
Vasotectablet10 mg/1oralREMEDYREPACK INC.2014-10-24Not applicableUs
Vasotectablet10 mg/1oralValeant Pharmaceuticals North America LLC1985-12-24Not applicableUs
Vasotectablet4 mgoralMerck Canada Inc1987-12-31Not applicableCanada
Vasotectablet20 mg/1oralREMEDYREPACK INC.2015-02-25Not applicableUs
Vasotectablet20 mg/1oralValeant Pharmaceuticals North America LLC1985-12-24Not applicableUs
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-enalapril Tab 10mgtablet10 mgoralApotex Inc1993-12-31Not applicableCanada
Apo-enalapril Tab 2.5mgtablet2.5 mgoralApotex Inc1993-12-31Not applicableCanada
Apo-enalapril Tab 20mgtablet20 mgoralApotex Inc1993-12-31Not applicableCanada
Apo-enalapril Tab 5mgtablet5 mgoralApotex Inc1993-12-31Not applicableCanada
Enalapril Maleatetablet20 mg/1oralREMEDYREPACK INC.2013-05-15Not applicableUs
Enalapril Maleatetablet10 mg/1oralBlenheim Pharmacal, Inc.2014-02-20Not applicableUs
Enalapril Maleatetablet5 mg/1oralCardinal Health2004-02-03Not applicableUs
Enalapril Maleatetablet2.5 mg/1oralSt Marys Medical Park Pharmacy2014-01-23Not applicableUs
Enalapril Maleatetablet20 mg/1oralLake Erie Medical DBA Quality Care Products LLC2009-12-11Not applicableUs
Enalapril Maleatetablet20 mg/1oralMylan Pharmaceuticals Inc.2000-08-22Not applicableUs
Enalapril Maleatetablet10 mg/1oralMylan Institutional Inc.2000-11-15Not applicableUs
Enalapril Maleatetablet10 mg/1oralContract Pharmacy Services Pa2010-04-07Not applicableUs
Enalapril Maleatetablet5 mg/1oralGolden State Medical Supply, Inc.2011-05-122015-11-30Us
Enalapril Maleatetablet5 mg/1oralTaro Pharmaceuticals U.S.A., Inc.2001-01-23Not applicableUs
Enalapril Maleatetablet5 mg/1oralMajor Pharmaceuticals2004-02-03Not applicableUs
Enalapril Maleatetablet2.5 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Enalapril Maleatetablet10 mg/1oralWockhardt Limited2009-12-11Not applicableUs
Enalapril Maleatetablet10 mg/1oralRebel Distributors Corp2009-12-11Not applicableUs
Enalapril Maleatetablet2.5 mg/1oralTeva Pharmaceuticals USA Inc2000-08-23Not applicableUs
Enalapril Maleatetablet20 mg/1oralUnit Dose Services2009-12-11Not applicableUs
Enalapril Maleatetablet5 mg/1oralWockhardt USA LLC.2009-12-11Not applicableUs
Enalapril Maleatetablet5 mg/1oralLegacy Pharmaceutical Packaging, Llc2009-12-11Not applicableUs
Enalapril Maleatetablet, soluble2.5 mg/1oralApace Packaging2009-08-22Not applicableUs
Enalapril Maleatetablet10 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Enalapril Maleatetablet5 mg/1oralNorthstar Rx LLC2015-08-06Not applicableUs
Enalapril Maleatetablet5 mg/1oralPd Rx Pharmaceuticals, Inc.2009-12-11Not applicableUs
Enalapril Maleatetablet5 mg/1oralbryant ranch prepack2009-12-11Not applicableUs
Enalapril Maleatetablet10 mg/1oralTaro Pharmaceuticals U.S.A., Inc.2001-01-232016-02-06Us
Enalapril Maleatetablet20 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2009-12-11Not applicableUs
Enalapril Maleatetablet10 mg/1oralMed Health Pharma, LLC2011-01-01Not applicableUs
Enalapril Maleatetablet5 mg/1oralAmerican Health Packaging2009-05-26Not applicableUs
Enalapril Maleatetablet20 mg/1oralREMEDYREPACK INC.2013-03-14Not applicableUs
Enalapril Maleatetablet10 mg/1oralBlenheim Pharmacal, Inc.2011-04-18Not applicableUs
Enalapril Maleatetablet5 mg/1oralPhysicians Total Care, Inc.2000-11-29Not applicableUs
Enalapril Maleatetablet10 mg/1oralGolden State Medical Supply, Inc.2013-11-04Not applicableUs
Enalapril Maleatetablet20 mg/1oralREMEDYREPACK INC.2013-03-15Not applicableUs
Enalapril Maleatetablet2.5 mg/1oralMylan Pharmaceuticals Inc.2000-08-22Not applicableUs
Enalapril Maleatetablet5 mg/1oralUnit Dose Services2009-12-11Not applicableUs
Enalapril Maleatetablet20 mg/1oralDispensing Solutions, Inc.2009-12-11Not applicableUs
Enalapril Maleatetablet10 mg/1oralPreferred Pharmaceuticals, Inc.2012-01-17Not applicableUs
Enalapril Maleatetablet10 mg/1oralREMEDYREPACK INC.2013-05-23Not applicableUs
Enalapril Maleatetablet20 mg/1oralBlenheim Pharmacal, Inc.2014-02-20Not applicableUs
Enalapril Maleatetablet10 mg/1oralCardinal Health2010-10-13Not applicableUs
Enalapril Maleatetablet20 mg/1oralSt Marys Medical Park Pharmacy2014-04-21Not applicableUs
Enalapril Maleatetablet5 mg/1oralLake Erie Medical DBA Quality Care Products LLC2009-12-11Not applicableUs
Enalapril Maleatetablet2.5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2009-12-11Not applicableUs
Enalapril Maleatetablet20 mg/1oralMylan Institutional Inc.2000-11-15Not applicableUs
Enalapril Maleatetablet20 mg/1oralContract Pharmacy Services Pa2010-06-28Not applicableUs
Enalapril Maleatetablet10 mg/1oralGolden State Medical Supply, Inc.2011-05-122015-11-30Us
Enalapril Maleatetablet10 mg/1oralTaro Pharmaceuticals U.S.A., Inc.2001-01-23Not applicableUs
Enalapril Maleatetablet2.5 mg/1oralMajor Pharmaceuticals2004-02-03Not applicableUs
Enalapril Maleatetablet2.5 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Enalapril Maleatetablet20 mg/1oralWockhardt Limited2009-12-11Not applicableUs
Enalapril Maleatetablet20 mg/1oralRebel Distributors Corp2009-12-11Not applicableUs
Enalapril Maleatetablet5 mg/1oralTeva Pharmaceuticals USA Inc2000-08-23Not applicableUs
Enalapril Maleatetablet2.5 mg/1oralUnit Dose Services2009-12-11Not applicableUs
Enalapril Maleatetablet10 mg/1oralWockhardt USA LLC.2009-12-11Not applicableUs
Enalapril Maleatetablet10 mg/1oralLegacy Pharmaceutical Packaging, Llc2009-12-11Not applicableUs
Enalapril Maleatetablet, soluble5 mg/1oralApace Packaging2009-08-22Not applicableUs
Enalapril Maleatetablet20 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Enalapril Maleatetablet10 mg/1oralNorthstar Rx LLC2015-08-06Not applicableUs
Enalapril Maleatetablet20 mg/1oralPd Rx Pharmaceuticals, Inc.2009-12-11Not applicableUs
Enalapril Maleatetablet2.5 mg/1oralbryant ranch prepack2009-12-11Not applicableUs
Enalapril Maleatetablet20 mg/1oralTaro Pharmaceuticals U.S.A., Inc.2001-01-232016-02-06Us
Enalapril Maleatetablet5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2000-08-22Not applicableUs
Enalapril Maleatetablet20 mg/1oralMed Health Pharma, LLC2011-01-01Not applicableUs
Enalapril Maleatetablet10 mg/1oralAmerican Health Packaging2009-05-26Not applicableUs
Enalapril Maleatetablet5 mg/1oralPreferred Pharmaceuticals, Inc.2012-01-17Not applicableUs
Enalapril Maleatetablet5 mg/1oralREMEDYREPACK INC.2012-10-03Not applicableUs
Enalapril Maleatetablet10 mg/1oralBlenheim Pharmacal, Inc.2013-11-25Not applicableUs
Enalapril Maleatetablet10 mg/1oralPhysicians Total Care, Inc.2000-11-29Not applicableUs
Enalapril Maleatetablet20 mg/1oralGolden State Medical Supply, Inc.2013-11-04Not applicableUs
Enalapril Maleatetablet2.5 mg/1oralLake Erie Medical DBA Quality Care Products LLC2000-08-22Not applicableUs
Enalapril Maleatetablet5 mg/1oralMylan Pharmaceuticals Inc.2000-08-22Not applicableUs
Enalapril Maleatetablet2.5 mg/1oralMylan Institutional Inc.2000-11-15Not applicableUs
Enalapril Maleatetablet5 mg/1oralContract Pharmacy Services Pa2010-08-02Not applicableUs
Enalapril Maleatetablet10 mg/1oralREMEDYREPACK INC.2014-06-03Not applicableUs
Enalapril Maleatetablet10 mg/1oralSTAT Rx USA LLC2009-12-11Not applicableUs
Enalapril Maleatetablet5 mg/1oralCardinal Health2010-10-13Not applicableUs
Enalapril Maleatetablet5 mg/1oralSt Marys Medical Park Pharmacy2014-04-21Not applicableUs
Enalapril Maleatetablet2.5 mg/1oralTaro Pharmaceuticals U.S.A., Inc.2001-01-232016-02-06Us
Enalapril Maleatetablet5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2009-12-11Not applicableUs
Enalapril Maleatetablet2.5 mg/1oralMed Health Pharma, LLC2011-01-01Not applicableUs
Enalapril Maleatetablet10 mg/1oralContract Pharmacy Services Pa2010-08-02Not applicableUs
Enalapril Maleatetablet20 mg/1oralTaro Pharmaceuticals U.S.A., Inc.2001-01-23Not applicableUs
Enalapril Maleatetablet10 mg/1oralMajor Pharmaceuticals2004-02-03Not applicableUs
Enalapril Maleatetablet20 mg/1oralPhysicians Total Care, Inc.2002-01-02Not applicableUs
Enalapril Maleatetablet2.5 mg/1oralGolden State Medical Supply, Inc.2013-11-04Not applicableUs
Enalapril Maleatetablet10 mg/1oralREMEDYREPACK INC.2013-11-12Not applicableUs
Enalapril Maleatetablet10 mg/1oralTeva Pharmaceuticals USA Inc2000-08-23Not applicableUs
Enalapril Maleatetablet2.5 mg/1oralUnit Dose Services2009-12-11Not applicableUs
Enalapril Maleatetablet20 mg/1oralWockhardt USA LLC.2009-12-11Not applicableUs
Enalapril Maleatetablet20 mg/1oralLegacy Pharmaceutical Packaging, Llc2009-12-11Not applicableUs
Enalapril Maleatetablet, soluble10 mg/1oralApace Packaging2009-08-22Not applicableUs
Enalapril Maleatetablet20 mg/1oralAmerican Health Packaging2009-05-26Not applicableUs
Enalapril Maleatetablet20 mg/1oralREMEDYREPACK INC.2011-04-08Not applicableUs
Enalapril Maleatetablet20 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Enalapril Maleatetablet20 mg/1oralNorthstar Rx LLC2015-08-06Not applicableUs
Enalapril Maleatetablet2.5 mg/1oralWockhardt Limited2009-12-11Not applicableUs
Enalapril Maleatetablet10 mg/1oralbryant ranch prepack2009-12-11Not applicableUs
Enalapril Maleatetablet2.5 mg/1oralREMEDYREPACK INC.2011-10-05Not applicableUs
Enalapril Maleatetablet10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2000-08-22Not applicableUs
Enalapril Maleatetablet20 mg/1oralNorthwind Pharmaceuticals, LLC2014-12-09Not applicableUs
Enalapril Maleatetablet10 mg/1oralMylan Pharmaceuticals Inc.2000-08-22Not applicableUs
Enalapril Maleatetablet5 mg/1oralMylan Institutional Inc.2000-11-15Not applicableUs
Enalapril Maleatetablet5 mg/1oralContract Pharmacy Services Pa2010-04-07Not applicableUs
Enalapril Maleatetablet2.5 mg/1oralGolden State Medical Supply, Inc.2011-05-122015-11-30Us
Enalapril Maleatetablet5 mg/1oralREMEDYREPACK INC.2013-05-09Not applicableUs
Enalapril Maleatetablet5 mg/1oralBlenheim Pharmacal, Inc.2013-12-10Not applicableUs
Enalapril Maleatetablet10 mg/1oralCardinal Health2004-02-03Not applicableUs
Enalapril Maleatetablet10 mg/1oralSt Marys Medical Park Pharmacy2014-01-23Not applicableUs
Enalapril Maleatetablet10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2009-12-11Not applicableUs
Enalapril Maleatetablet5 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Enalapril Maleatetablet2.5 mg/1oralNorthstar Rx LLC2015-08-06Not applicableUs
Enalapril Maleatetablet10 mg/1oralPd Rx Pharmaceuticals, Inc.2009-12-11Not applicableUs
Enalapril Maleatetablet10 mg/1oralDIRECT RX2015-12-03Not applicableUs
Enalapril Maleatetablet5 mg/1oralTaro Pharmaceuticals U.S.A., Inc.2001-01-232016-02-06Us
Enalapril Maleatetablet10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2009-12-11Not applicableUs
Enalapril Maleatetablet5 mg/1oralMed Health Pharma, LLC2011-01-01Not applicableUs
Enalapril Maleatetablet20 mg/1oralContract Pharmacy Services Pa2010-08-02Not applicableUs
Enalapril Maleatetablet5 mg/1oralREMEDYREPACK INC.2013-03-11Not applicableUs
Enalapril Maleatetablet20 mg/1oralMajor Pharmaceuticals2004-02-03Not applicableUs
Enalapril Maleatetablet2.5 mg/1oralPhysicians Total Care, Inc.2002-09-12Not applicableUs
Enalapril Maleatetablet5 mg/1oralGolden State Medical Supply, Inc.2013-11-04Not applicableUs
Enalapril Maleatetablet10 mg/1oralREMEDYREPACK INC.2013-06-14Not applicableUs
Enalapril Maleatetablet20 mg/1oralTeva Pharmaceuticals USA Inc2000-08-23Not applicableUs
Enalapril Maleatetablet10 mg/1oralUnit Dose Services2009-12-11Not applicableUs
Enalapril Maleatetablet5 mg/1oralTYA Pharmaceuticals2009-12-11Not applicableUs
Enalapril Maleatetablet20 mg/1oralPreferred Pharmaceuticals, Inc.2012-01-17Not applicableUs
Enalapril Maleatetablet, soluble20 mg/1oralApace Packaging2009-08-22Not applicableUs
Enalapril Maleatetablet2.5 mg/1oralWockhardt USA LLC.2009-12-11Not applicableUs
Enalapril Maleatetablet2.5 mg/1oralREMEDYREPACK INC.2011-10-11Not applicableUs
Enalapril Maleatetablet20 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2000-08-22Not applicableUs
Enalapril Maleatetablet2.5 mg/1oralTaro Pharmaceuticals U.S.A., Inc.2001-01-23Not applicableUs
Enalapril Maleatetablet2.5 mg/1oralLegacy Pharmaceutical Packaging, Llc2009-12-11Not applicableUs
Enalapril Maleatetablet5 mg/1oralREMEDYREPACK INC.2016-01-22Not applicableUs
Enalapril Maleatetablet2.5 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Enalapril Maleatetablet5 mg/1oralRebel Distributors Corp2009-12-11Not applicableUs
Enalapril Maleatetablet5 mg/1oralWockhardt Limited2009-12-11Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AcetecAlphapharm
AcetensilGrünenthal
AlaprenRanbaxy
AmotacMass Pharma
AmpraceMerck Sharp & Dohme
DilvasCipla
DiotensilMintlab
DrepatilFada
EnaceAbbott
EnaHexalSandoz
EnalEast West
EnalapotenDel Bel
EnprilWockhardt
FeliberalSilanes
GadoprilGador (Argentina)
GliotenBago
KinfilNova Argentia (Argentina)
Vasotec IVSandoz (Canada)
Brand mixtures
NameLabellerIngredients
Apo-enalapril Maleate/hctzApotex Inc
Enalapril Maleate and HydrochlorothiazideTeva Pharmaceuticals USA Inc
Enalapril/hctzFrosst A Division Of Merck Canada Inc
Teva-enalapril/hctzTeva Canada Limited
VasereticValeant Pharmaceuticals North America LLC
Salts
Name/CASStructureProperties
Enalapril maleate
ThumbNot applicableDBSALT001036
Enalapril sodium
ThumbNot applicableDBSALT001143
Categories
UNII69PN84IO1A
CAS number75847-73-3
WeightAverage: 376.4467
Monoisotopic: 376.199822016
Chemical FormulaC20H28N2O5
InChI KeyInChIKey=GBXSMTUPTTWBMN-XIRDDKMYSA-N
InChI
InChI=1S/C20H28N2O5/c1-3-27-20(26)16(12-11-15-8-5-4-6-9-15)21-14(2)18(23)22-13-7-10-17(22)19(24)25/h4-6,8-9,14,16-17,21H,3,7,10-13H2,1-2H3,(H,24,25)/t14-,16-,17-/m0/s1
IUPAC Name
(2S)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]pyrrolidine-2-carboxylic acid
SMILES
CCOC(=O)[[email protected]](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N1CCC[[email protected]]1C(O)=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as peptides. These are compounds containing an amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentPeptides
Alternative Parents
Substituents
  • Alpha peptide
  • N-acyl-alpha amino acid or derivatives
  • N-acyl-alpha-amino acid
  • Alpha-amino acid ester
  • Alpha-amino acid amide
  • Phenylpropylamine
  • Alpha-amino acid or derivatives
  • N-substituted-alpha-amino acid
  • Pyrrolidine carboxylic acid or derivatives
  • Pyrrolidine carboxylic acid
  • N-acylpyrrolidine
  • Aralkylamine
  • Fatty acid ester
  • Fatty acyl
  • Benzenoid
  • Dicarboxylic acid or derivatives
  • Monocyclic benzene moiety
  • Tertiary carboxylic acid amide
  • Pyrrolidine
  • Tertiary amine
  • Carboxylic acid ester
  • Carboxamide group
  • Azacycle
  • Organoheterocyclic compound
  • Secondary amine
  • Secondary aliphatic amine
  • Carboxylic acid
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of essential or renovascular hypertension and symptomatic congestive heart failure. It may be used alone or in combination with thiazide diuretics.
PharmacodynamicsEnalapril is a prodrug that is rapidly metabolized by liver esterases to enalaprilat following oral administration. Enalapril itself has little pharmacologic activity. Enalaprilat lowers blood pressure by antagonizing the effect of the RAAS. The RAAS is a homeostatic mechanism for regulating hemodynamics, water and electrolyte balance. During sympathetic stimulation or when renal blood pressure or blood flow is reduced, renin is released from the granular cells of the juxtaglomerular apparatus in the kidneys. In the blood stream, renin cleaves circulating angiotensinogen to ATI, which is subsequently cleaved to ATII by ACE. ATII increases blood pressure using a number of mechanisms. First, it stimulates the secretion of aldosterone from the adrenal cortex. Aldosterone travels to the distal convoluted tubule (DCT) and collecting tubule of nephrons where it increases sodium and water reabsorption by increasing the number of sodium channels and sodium-potassium ATPases on cell membranes. Second, ATII stimulates the secretion of vasopressin (also known as antidiuretic hormone or ADH) from the posterior pituitary gland. ADH stimulates further water reabsorption from the kidneys via insertion of aquaporin-2 channels on the apical surface of cells of the DCT and collecting tubules. Third, ATII increases blood pressure through direct arterial vasoconstriction. Stimulation of the Type 1 ATII receptor on vascular smooth muscle cells leads to a cascade of events resulting in myocyte contraction and vasoconstriction. In addition to these major effects, ATII induces the thirst response via stimulation of hypothalamic neurons. ACE inhibitors inhibit the rapid conversion of ATI to ATII and antagonize RAAS-induced increases in blood pressure. ACE (also known as kininase II) is also involved in the enzymatic deactivation of bradykinin, a vasodilator. Inhibiting the deactivation of bradykinin increases bradykinin levels and may sustain the effects of enalaprilat by causing increased vasodilation and decreased blood pressure.
Mechanism of actionThere are two isoforms of ACE: the somatic isoform, which exists as a glycoprotein comprised of a single polypeptide chain of 1277; and the testicular isoform, which has a lower molecular mass and is thought to play a role in sperm maturation and binding of sperm to the oviduct epithelium. Somatic ACE has two functionally active domains, N and C, which arise from tandem gene duplication. Although the two domains have high sequence similarity, they play distinct physiological roles. The C-domain is predominantly involved in blood pressure regulation while the N-domain plays a role in hematopoietic stem cell differentiation and proliferation. ACE inhibitors bind to and inhibit the activity of both domains, but have much greater affinity for and inhibitory activity against the C-domain. Enalaprilat, the principle active metabolite of enalapril, competes with ATI for binding to ACE and inhibits and enzymatic proteolysis of ATI to ATII. Decreasing ATII levels in the body decreases blood pressure by inhibiting the pressor effects of ATII as described in the Pharmacology section above. Enalapril also causes an increase in plasma renin activity likely due to a loss of feedback inhibition mediated by ATII on the release of renin and/or stimulation of reflex mechanisms via baroreceptors. Enalaprilat's affinity for ACE is approximately 200,000 times greater than that of ATI and 300-1000 times greater than that enalapril.
Related Articles
Absorption55-75%, absorption is unaffected by food; enalaprilat (clinically administered IV) is poorly absorbed, 3-12%, due to its high polarity.
Volume of distributionNot Available
Protein binding50-60% of enalaprilat is bound to plasma proteins
Metabolism

~ 60% of absorbed dose is extensively hydrolyzed to enalaprilat, primarily by liver esterases

SubstrateEnzymesProduct
Enalapril
Not Available
EnalaprilatDetails
Route of eliminationExcretion of enalapril is primarily renal.
Half life< 2 hours for unchanged enalapril in health individuals, may be increased in those with congestive heart failure (3.4 and 5.8 hours for single 5- and 10-mg doses, respectively). The average terminal half life of enalaprilat is 35-38 hours. The effective half life following multiple doses is 11-14 hours.
ClearanceNot Available
ToxicityOverdosage may result in marked hypotension and stupor. Most common adverse effects include hypotension, headache, dizziness and fatigue.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Enalapril Action PathwayDrug actionSMP00148
Enalapril Metabolism PathwayDrug metabolismSMP00593
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.7428
Blood Brain Barrier-0.9659
Caco-2 permeable-0.8956
P-glycoprotein substrateSubstrate0.7691
P-glycoprotein inhibitor INon-inhibitor0.6681
P-glycoprotein inhibitor IINon-inhibitor0.5136
Renal organic cation transporterNon-inhibitor0.8442
CYP450 2C9 substrateNon-substrate0.8632
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateNon-substrate0.5696
CYP450 1A2 substrateNon-inhibitor0.9125
CYP450 2C9 inhibitorNon-inhibitor0.9154
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.8309
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.6825
Ames testNon AMES toxic0.9383
CarcinogenicityNon-carcinogens0.9216
BiodegradationNot ready biodegradable0.8686
Rat acute toxicity1.8269 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9719
hERG inhibition (predictor II)Non-inhibitor0.7456
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Apotex inc
  • Apothecon inc div bristol myers squibb
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Krka dd novo mesto
  • Lek pharmaceuticals d d
  • Mylan pharmaceuticals inc
  • Ranbaxy laboratories ltd
  • Sandoz inc
  • Taro pharmaceutical industries ltd
  • Teva pharmaceuticals usa inc
  • Watson laboratories inc
  • Wockhardt americas inc
  • Biovail laboratories international srl
  • Bedford laboratories div ben venue laboratories inc
  • Hikma farmaceutica (portugal) sa
  • Hospira inc
  • Teva parenteral medicines inc
Packagers
Dosage forms
FormRouteStrength
Tabletoral10 mg
Tabletoral2.5 mg
Tabletoral20 mg
Tabletoral5 mg
Tabletoral10.0 mg
Tabletoral20.0 mg
Tabletoral5.0 mg
Tabletoral10 mg/1
Tabletoral2.5 mg/1
Tabletoral20 mg/1
Tabletoral5 mg/1
Tablet, solubleoral10 mg/1
Tablet, solubleoral2.5 mg/1
Tablet, solubleoral20 mg/1
Tablet, solubleoral5 mg/1
Tabletoral
Kit
Tabletoral2.0 mg
Tabletoral4.0 mg
Tabletoral8.0 mg
Tabletoral16 mg
Tabletoral32 mg
Tabletoral4 mg
Tabletoral8 mg
Tabletoral2 mg
Prices
Unit descriptionCostUnit
Enalapril maleate powder9.18USD g
Enalaprilat 1.25 mg/ml vial3.6USD ml
Vasotec 20 mg tablet3.36USD tablet
Vaseretic 10-25 mg tablet3.15USD tablet
Vasotec 10 mg tablet2.63USD tablet
Vasotec 5 mg tablet2.08USD tablet
Vasotec 2.5 mg tablet1.65USD tablet
Enalapril maleate 20 mg tablet1.56USD tablet
Vaseretic 5-12.5 mg tablet1.49USD tablet
Vasotec 20 mg Tablet1.34USD tablet
Vasotec 10 mg Tablet1.11USD tablet
Enalapril maleate 10 mg tablet1.09USD tablet
Enalapril maleate 5 mg tablet1.03USD tablet
Vasotec 5 mg Tablet0.92USD tablet
Enalapril maleate 2.5 mg tablet0.82USD tablet
Vasotec 2.5 mg Tablet0.78USD tablet
Apo-Enalapril 20 mg Tablet0.75USD tablet
Co Enalapril 20 mg Tablet0.75USD tablet
Mylan-Enalapril 20 mg Tablet0.75USD tablet
Novo-Enalapril 20 mg Tablet0.75USD tablet
Pms-Enalapril 20 mg Tablet0.75USD tablet
Ratio-Enalapril 20 mg Tablet0.75USD tablet
Sandoz Enalapril 20 mg Tablet0.75USD tablet
Taro-Enalapril 20 mg Tablet0.75USD tablet
Apo-Enalapril 10 mg Tablet0.62USD tablet
Co Enalapril 10 mg Tablet0.62USD tablet
Mylan-Enalapril 10 mg Tablet0.62USD tablet
Novo-Enalapril 10 mg Tablet0.62USD tablet
Pms-Enalapril 10 mg Tablet0.62USD tablet
Ratio-Enalapril 10 mg Tablet0.62USD tablet
Sandoz Enalapril 10 mg Tablet0.62USD tablet
Taro-Enalapril 10 mg Tablet0.62USD tablet
Apo-Enalapril 5 mg Tablet0.52USD tablet
Co Enalapril 5 mg Tablet0.52USD tablet
Mylan-Enalapril 5 mg Tablet0.52USD tablet
Novo-Enalapril 5 mg Tablet0.52USD tablet
Pms-Enalapril 5 mg Tablet0.52USD tablet
Ratio-Enalapril 5 mg Tablet0.52USD tablet
Sandoz Enalapril 5 mg Tablet0.52USD tablet
Taro-Enalapril 5 mg Tablet0.52USD tablet
Apo-Enalapril 2.5 mg Tablet0.44USD tablet
Co Enalapril 2.5 mg Tablet0.44USD tablet
Mylan-Enalapril 2.5 mg Tablet0.44USD tablet
Novo-Enalapril 2.5 mg Tablet0.44USD tablet
Pms-Enalapril 2.5 mg Tablet0.44USD tablet
Ratio-Enalapril 2.5 mg Tablet0.44USD tablet
Sandoz Enalapril 2.5 mg Tablet0.44USD tablet
Taro-Enalapril 2.5 mg Tablet0.44USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US8568747 No2012-11-062032-11-06Us
US8778366 No2012-11-062032-11-06Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point143-144.5 °CNot Available
water solubility1.64E+004 mg/L (at 25 °C)MCFARLAND,JW ET AL. (2001)
logP0.07HANSCH,C ET AL. (1995)
Caco2 permeability-5.64ADME Research, USCD
pKa2.97 (the carboxyl group) and 5.35 (the amine group) at 25°CNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.213 mg/mLALOGPS
logP0.19ALOGPS
logP0.59ChemAxon
logS-3.2ALOGPS
pKa (Strongest Acidic)3.67ChemAxon
pKa (Strongest Basic)5.2ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area95.94 Å2ChemAxon
Rotatable Bond Count10ChemAxon
Refractivity99.57 m3·mol-1ChemAxon
Polarizability40.41 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

K. S. Keshava Murthy, Andrew Burchat, Gamini Weeratunga, “Sodium enalapril complex and the use thereof to make sodium enalapril.” U.S. Patent US5637730, issued February, 1983.

US5637730
General References
  1. Florey, Klaus;Al-Badr, Abdullah A.;Brenner, Gerald S. (1987). Analytical Profiles of Drug Substances (16th ed.). Elsevier Science & Technology Books. [ISBN:978-0-12-260816-2 ]
External Links
ATC CodesC09BB06C09BB02C09BA02C09AA02
AHFS Codes
  • 24:32.04
PDB Entries
FDA labelDownload (939 KB)
MSDSNot Available
Interactions
Drug Interactions
Drug
7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE may increase the hypotensive activities of Enalapril.
AbacavirThe serum concentration of Abacavir can be decreased when it is combined with Enalapril.
AcebutololEnalapril may increase the hypotensive activities of Acebutolol.
AceclofenacThe risk or severity of adverse effects can be increased when Enalapril is combined with Aceclofenac.
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Enalapril.
AcetazolamideThe risk or severity of adverse effects can be increased when Enalapril is combined with Acetazolamide.
Acetylsalicylic acidThe risk or severity of adverse effects can be increased when Enalapril is combined with Acetylsalicylic acid.
Acetylsalicylic acidAcetylsalicylic acid may decrease the antihypertensive activities of Enalapril.
AdapaleneThe risk or severity of adverse effects can be increased when Enalapril is combined with Adapalene.
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Enalapril.
AldesleukinThe risk or severity of adverse effects can be increased when Aldesleukin is combined with Enalapril.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Enalapril.
AlfuzosinAlfuzosin may increase the hypotensive activities of Enalapril.
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Enalapril.
AliskirenEnalapril may increase the hypotensive activities of Aliskiren.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Enalapril.
AllopurinolThe risk of a hypersensitivity reaction to Allopurinol is increased when it is combined with Enalapril.
AlogliptinThe risk or severity of adverse effects can be increased when Alogliptin is combined with Enalapril.
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Enalapril.
AlprenololEnalapril may increase the hypotensive activities of Alprenolol.
AmbrisentanEnalapril may increase the hypotensive activities of Ambrisentan.
AmifostineEnalapril may increase the hypotensive activities of Amifostine.
AmilorideThe risk or severity of adverse effects can be increased when Enalapril is combined with Amiloride.
AmineptineThe serum concentration of Amineptine can be increased when it is combined with Enalapril.
AminophyllineThe serum concentration of Aminophylline can be decreased when it is combined with Enalapril.
Aminosalicylic AcidAminosalicylic Acid may decrease the antihypertensive activities of Enalapril.
AmiodaroneThe metabolism of Enalapril can be decreased when combined with Amiodarone.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Enalapril.
AmlodipineAmlodipine may increase the hypotensive activities of Enalapril.
AmobarbitalAmobarbital may increase the hypotensive activities of Enalapril.
Amyl NitriteThe risk or severity of adverse effects can be increased when Enalapril is combined with Amyl Nitrite.
AntipyrineThe risk or severity of adverse effects can be increased when Enalapril is combined with Antipyrine.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Enalapril.
ApraclonidineThe risk or severity of adverse effects can be increased when Enalapril is combined with Apraclonidine.
ApremilastThe risk or severity of adverse effects can be increased when Enalapril is combined with Apremilast.
AprepitantThe serum concentration of Enalapril can be increased when it is combined with Aprepitant.
AprotininAprotinin may decrease the antihypertensive activities of Enalapril.
ArdeparinArdeparin may increase the hyperkalemic activities of Enalapril.
AripiprazoleAripiprazole may increase the hypotensive activities of Enalapril.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Enalapril.
AtazanavirThe metabolism of Enalapril can be decreased when combined with Atazanavir.
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Enalapril.
AtenololAtenolol may increase the hypotensive activities of Enalapril.
AtomoxetineThe metabolism of Enalapril can be decreased when combined with Atomoxetine.
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Enalapril.
AtorvastatinThe risk or severity of adverse effects can be increased when Atorvastatin is combined with Enalapril.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Enalapril.
AzapropazoneThe risk or severity of adverse effects can be increased when Enalapril is combined with Azapropazone.
AzathioprineEnalapril may increase the myelosuppressive activities of Azathioprine.
AzelastineThe risk or severity of adverse effects can be increased when Enalapril is combined with Azelastine.
Azilsartan medoxomilThe risk or severity of adverse effects can be increased when Enalapril is combined with Azilsartan medoxomil.
BalsalazideThe risk or severity of adverse effects can be increased when Enalapril is combined with Balsalazide.
BarbitalBarbital may increase the hypotensive activities of Enalapril.
BemiparinBemiparin may increase the hyperkalemic activities of Enalapril.
BenazeprilBenazepril may increase the hypotensive activities of Enalapril.
BendroflumethiazideBendroflumethiazide may increase the hypotensive activities of Enalapril.
BenmoxinBenmoxin may increase the hypotensive activities of Enalapril.
BenoxaprofenThe risk or severity of adverse effects can be increased when Enalapril is combined with Benoxaprofen.
BepridilEnalapril may increase the hypotensive activities of Bepridil.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Enalapril.
BetaxololBetaxolol may increase the hypotensive activities of Enalapril.
BethanidineBethanidine may increase the hypotensive activities of Enalapril.
BexaroteneThe serum concentration of Enalapril can be decreased when it is combined with Bexarotene.
BimatoprostEnalapril may increase the hypotensive activities of Bimatoprost.
BisoprololEnalapril may increase the hypotensive activities of Bisoprolol.
BoceprevirThe serum concentration of Enalapril can be decreased when it is combined with Boceprevir.
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Enalapril.
BortezomibThe metabolism of Enalapril can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Enalapril can be decreased when it is combined with Bosentan.
BosentanEnalapril may increase the hypotensive activities of Bosentan.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Enalapril.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Enalapril.
BretyliumEnalapril may increase the hypotensive activities of Bretylium.
BrimonidineEnalapril may increase the hypotensive activities of Brimonidine.
BrimonidineBrimonidine may increase the antihypertensive activities of Enalapril.
BromfenacThe risk or severity of adverse effects can be increased when Enalapril is combined with Bromfenac.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Enalapril.
BumetanideThe risk or severity of adverse effects can be increased when Enalapril is combined with Bumetanide.
BupranololEnalapril may increase the hypotensive activities of Bupranolol.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Enalapril.
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Enalapril.
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Enalapril.
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Enalapril.
CanagliflozinCanagliflozin may increase the hyperkalemic activities of Enalapril.
CanagliflozinThe risk or severity of adverse effects can be increased when Enalapril is combined with Canagliflozin.
CandesartanEnalapril may increase the hypotensive activities of Candesartan.
CandoxatrilEnalapril may increase the hypotensive activities of Candoxatril.
CaptoprilEnalapril may increase the hypotensive activities of Captopril.
CarbamazepineThe metabolism of Enalapril can be increased when combined with Carbamazepine.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Enalapril.
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Enalapril.
CaroxazoneCaroxazone may increase the hypotensive activities of Enalapril.
CarprofenThe risk or severity of adverse effects can be increased when Enalapril is combined with Carprofen.
CarteololCarteolol may increase the hypotensive activities of Enalapril.
CarvedilolEnalapril may increase the hypotensive activities of Carvedilol.
CastanospermineThe risk or severity of adverse effects can be increased when Enalapril is combined with Castanospermine.
CelecoxibThe risk or severity of adverse effects can be increased when Enalapril is combined with Celecoxib.
CeliprololEnalapril may increase the hypotensive activities of Celiprolol.
CeritinibThe serum concentration of Enalapril can be increased when it is combined with Ceritinib.
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Enalapril.
CertoparinCertoparin may increase the hyperkalemic activities of Enalapril.
ChloroquineThe risk or severity of adverse effects can be increased when Enalapril is combined with Chloroquine.
ChlorothiazideEnalapril may increase the hypotensive activities of Chlorothiazide.
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Enalapril.
ChlorthalidoneChlorthalidone may increase the hypotensive activities of Enalapril.
CilazaprilEnalapril may increase the hypotensive activities of Cilazapril.
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Enalapril.
CiprofloxacinEnalapril may increase the arrhythmogenic activities of Ciprofloxacin.
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Enalapril.
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Enalapril.
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Enalapril.
ClarithromycinThe metabolism of Enalapril can be decreased when combined with Clarithromycin.
ClarithromycinThe serum concentration of Clarithromycin can be increased when it is combined with Enalapril.
ClemastineThe metabolism of Enalapril can be decreased when combined with Clemastine.
ClevidipineThe risk or severity of adverse effects can be increased when Enalapril is combined with Clevidipine.
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Enalapril.
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Enalapril.
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Enalapril.
ClonidineClonidine may increase the hypotensive activities of Enalapril.
ClonixinThe risk or severity of adverse effects can be increased when Enalapril is combined with Clonixin.
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Enalapril.
ClotrimazoleThe metabolism of Enalapril can be decreased when combined with Clotrimazole.
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Enalapril.
CobicistatThe metabolism of Enalapril can be decreased when combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Enalapril.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Enalapril.
ConivaptanThe serum concentration of Enalapril can be increased when it is combined with Conivaptan.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Enalapril.
CrizotinibThe metabolism of Enalapril can be decreased when combined with Crizotinib.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Enalapril.
CryptenamineEnalapril may increase the hypotensive activities of Cryptenamine.
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Enalapril.
CyclophosphamideThe risk or severity of adverse effects can be increased when Enalapril is combined with Cyclophosphamide.
CyclosporineThe metabolism of Enalapril can be decreased when combined with Cyclosporine.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Enalapril.
CyclothiazideEnalapril may increase the hypotensive activities of Cyclothiazide.
D-LimoneneThe risk or severity of adverse effects can be increased when Enalapril is combined with D-Limonene.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Enalapril.
DabrafenibThe serum concentration of Enalapril can be decreased when it is combined with Dabrafenib.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Enalapril.
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Enalapril.
DalteparinDalteparin may increase the hyperkalemic activities of Enalapril.
DapagliflozinThe risk or severity of adverse effects can be increased when Enalapril is combined with Dapagliflozin.
DapoxetineDapoxetine may increase the orthostatic hypotensive activities of Enalapril.
DarunavirThe metabolism of Enalapril can be decreased when combined with Darunavir.
DasatinibThe serum concentration of Enalapril can be increased when it is combined with Dasatinib.
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Enalapril.
DebrisoquinEnalapril may increase the hypotensive activities of Debrisoquin.
DeferasiroxThe serum concentration of Enalapril can be decreased when it is combined with Deferasirox.
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Enalapril.
DelavirdineThe metabolism of Enalapril can be decreased when combined with Delavirdine.
DeserpidineEnalapril may increase the hypotensive activities of Deserpidine.
DesipramineThe serum concentration of Desipramine can be increased when it is combined with Enalapril.
DexamethasoneThe serum concentration of Enalapril can be decreased when it is combined with Dexamethasone.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Enalapril.
DexmedetomidineThe risk or severity of adverse effects can be increased when Enalapril is combined with Dexmedetomidine.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Enalapril.
DiazoxideDiazoxide may increase the hypotensive activities of Enalapril.
DiclofenacThe risk or severity of adverse effects can be increased when Enalapril is combined with Diclofenac.
DiclofenamideThe risk or severity of adverse effects can be increased when Enalapril is combined with Diclofenamide.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Enalapril.
DiflunisalThe risk or severity of adverse effects can be increased when Enalapril is combined with Diflunisal.
DiflunisalDiflunisal may decrease the antihypertensive activities of Enalapril.
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Enalapril.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Enalapril.
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Enalapril.
DihydroergotamineThe metabolism of Enalapril can be decreased when combined with Dihydroergotamine.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Enalapril.
DiltiazemDiltiazem may increase the hypotensive activities of Enalapril.
DinutuximabThe risk or severity of adverse effects can be increased when Enalapril is combined with Dinutuximab.
DipyridamoleThe risk or severity of adverse effects can be increased when Enalapril is combined with Dipyridamole.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Enalapril.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Enalapril.
DorzolamideEnalapril may increase the hypotensive activities of Dorzolamide.
DosulepinThe serum concentration of Dosulepin can be increased when it is combined with Enalapril.
DoxazosinEnalapril may increase the hypotensive activities of Doxazosin.
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Enalapril.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Enalapril.
DoxycyclineThe metabolism of Enalapril can be decreased when combined with Doxycycline.
DronedaroneThe metabolism of Enalapril can be decreased when combined with Dronedarone.
DrospirenoneEnalapril may increase the hyperkalemic activities of Drospirenone.
DroxicamThe risk or severity of adverse effects can be increased when Enalapril is combined with Droxicam.
DuloxetineEnalapril may increase the orthostatic hypotensive activities of Duloxetine.
DyphyllineThe serum concentration of Dyphylline can be decreased when it is combined with Enalapril.
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Enalapril.
EfavirenzThe serum concentration of Enalapril can be decreased when it is combined with Efavirenz.
EfonidipineEnalapril may increase the hypotensive activities of Efonidipine.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Enalapril.
EmpagliflozinThe risk or severity of adverse effects can be increased when Enalapril is combined with Empagliflozin.
EnalaprilatEnalapril may increase the hypotensive activities of Enalaprilat.
EnfuvirtideThe serum concentration of Enfuvirtide can be increased when it is combined with Enalapril.
EnoxaparinEnoxaparin may increase the hyperkalemic activities of Enalapril.
EnzalutamideThe serum concentration of Enalapril can be decreased when it is combined with Enzalutamide.
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Enalapril.
EpirizoleThe risk or severity of adverse effects can be increased when Enalapril is combined with Epirizole.
EplerenoneEplerenone may increase the hyperkalemic activities of Enalapril.
EplerenoneThe risk or severity of adverse effects can be increased when Enalapril is combined with Eplerenone.
EpoprostenolEnalapril may increase the hypotensive activities of Epoprostenol.
EprosartanEnalapril may increase the hypotensive activities of Eprosartan.
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Enalapril.
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Enalapril.
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Enalapril.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Enalapril.
ErythromycinThe metabolism of Enalapril can be decreased when combined with Erythromycin.
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Enalapril.
Eslicarbazepine acetateThe serum concentration of Enalapril can be decreased when it is combined with Eslicarbazepine acetate.
EsmirtazapineThe serum concentration of Esmirtazapine can be increased when it is combined with Enalapril.
EsmololThe risk or severity of adverse effects can be increased when Esmolol is combined with Enalapril.
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Enalapril.
EstriolThe serum concentration of Estriol can be increased when it is combined with Enalapril.
EstroneThe serum concentration of Estrone can be increased when it is combined with Enalapril.
Etacrynic acidThe risk or severity of adverse effects can be increased when Enalapril is combined with Etacrynic acid.
EtanerceptThe risk or severity of adverse effects can be increased when Enalapril is combined with Etanercept.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Enalapril.
EtodolacThe risk or severity of adverse effects can be increased when Enalapril is combined with Etodolac.
EtofenamateThe risk or severity of adverse effects can be increased when Enalapril is combined with Etofenamate.
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Enalapril.
EtoricoxibThe risk or severity of adverse effects can be increased when Enalapril is combined with Etoricoxib.
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Enalapril.
Evening primrose oilThe risk or severity of adverse effects can be increased when Enalapril is combined with Evening primrose oil.
EverolimusThe risk or severity of adverse effects can be increased when Everolimus is combined with Enalapril.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Enalapril.
exisulindThe risk or severity of adverse effects can be increased when Enalapril is combined with exisulind.
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Enalapril.
FelodipineEnalapril may increase the hypotensive activities of Felodipine.
FenbufenThe risk or severity of adverse effects can be increased when Enalapril is combined with Fenbufen.
FenoldopamEnalapril may increase the hypotensive activities of Fenoldopam.
FenoprofenThe risk or severity of adverse effects can be increased when Enalapril is combined with Fenoprofen.
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Enalapril.
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Enalapril.
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Enalapril.
FloctafenineThe risk or severity of adverse effects can be increased when Enalapril is combined with Floctafenine.
FluconazoleThe metabolism of Enalapril can be decreased when combined with Fluconazole.
FlunixinThe risk or severity of adverse effects can be increased when Enalapril is combined with Flunixin.
FlurbiprofenThe risk or severity of adverse effects can be increased when Enalapril is combined with Flurbiprofen.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Enalapril.
FluvoxamineThe metabolism of Enalapril can be decreased when combined with Fluvoxamine.
ForasartanThe risk or severity of adverse effects can be increased when Forasartan is combined with Enalapril.
FosamprenavirThe metabolism of Enalapril can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Enalapril can be increased when it is combined with Fosaprepitant.
FosinoprilFosinopril may increase the hypotensive activities of Enalapril.
FosphenytoinThe metabolism of Enalapril can be increased when combined with Fosphenytoin.
FurazolidoneFurazolidone may increase the hypotensive activities of Enalapril.
FurosemideThe risk or severity of adverse effects can be increased when Enalapril is combined with Furosemide.
Fusidic AcidThe serum concentration of Enalapril can be increased when it is combined with Fusidic Acid.
GarlicThe serum concentration of Enalapril can be decreased when it is combined with Garlic.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Enalapril.
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Enalapril.
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Enalapril.
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Enalapril.
GuanabenzEnalapril may increase the hypotensive activities of Guanabenz.
GuanadrelGuanadrel may increase the hypotensive activities of Enalapril.
GuanethidineEnalapril may increase the hypotensive activities of Guanethidine.
GuanfacineEnalapril may increase the hypotensive activities of Guanfacine.
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Enalapril.
HeparinHeparin may increase the hyperkalemic activities of Enalapril.
HexamethoniumEnalapril may increase the hypotensive activities of Hexamethonium.
HexobarbitalHexobarbital may increase the hypotensive activities of Enalapril.
HMPL-004The risk or severity of adverse effects can be increased when Enalapril is combined with HMPL-004.
HydracarbazineHydracarbazine may increase the hypotensive activities of Enalapril.
HydralazineEnalapril may increase the hypotensive activities of Hydralazine.
HydrochlorothiazideEnalapril may increase the hypotensive activities of Hydrochlorothiazide.
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Enalapril.
HydroflumethiazideEnalapril may increase the hypotensive activities of Hydroflumethiazide.
IbuprofenThe risk or severity of adverse effects can be increased when Enalapril is combined with Ibuprofen.
IbuproxamThe risk or severity of adverse effects can be increased when Enalapril is combined with Ibuproxam.
IcatibantIcatibant may decrease the antihypertensive activities of Enalapril.
IcatibantThe risk or severity of adverse effects can be increased when Enalapril is combined with Icatibant.
IdelalisibThe serum concentration of Enalapril can be increased when it is combined with Idelalisib.
IloprostIloprost may increase the hypotensive activities of Enalapril.
ImatinibThe metabolism of Enalapril can be decreased when combined with Imatinib.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Enalapril.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Enalapril.
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Enalapril.
IndapamideEnalapril may increase the hypotensive activities of Indapamide.
IndenololEnalapril may increase the hypotensive activities of Indenolol.
IndinavirThe metabolism of Enalapril can be decreased when combined with Indinavir.
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Enalapril.
IndomethacinThe risk or severity of adverse effects can be increased when Enalapril is combined with Indomethacin.
IndoprofenThe risk or severity of adverse effects can be increased when Enalapril is combined with Indoprofen.
IndoraminEnalapril may increase the hypotensive activities of Indoramin.
IproclozideIproclozide may increase the hypotensive activities of Enalapril.
IproniazidIproniazid may increase the hypotensive activities of Enalapril.
IrbesartanEnalapril may increase the hypotensive activities of Irbesartan.
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Enalapril.
IronThe risk or severity of adverse effects can be increased when Enalapril is combined with Iron.
Iron DextranThe risk or severity of adverse effects can be increased when Enalapril is combined with Iron Dextran.
IsavuconazoniumThe metabolism of Enalapril can be decreased when combined with Isavuconazonium.
IsocarboxazidIsocarboxazid may increase the hypotensive activities of Enalapril.
Isosorbide DinitrateThe risk or severity of adverse effects can be increased when Enalapril is combined with Isosorbide Dinitrate.
Isosorbide MononitrateThe risk or severity of adverse effects can be increased when Enalapril is combined with Isosorbide Mononitrate.
IsoxicamThe risk or severity of adverse effects can be increased when Enalapril is combined with Isoxicam.
IsoxsuprineThe risk or severity of adverse effects can be increased when Enalapril is combined with Isoxsuprine.
IsradipineIsradipine may increase the hypotensive activities of Enalapril.
ItraconazoleThe metabolism of Enalapril can be decreased when combined with Itraconazole.
IvacaftorThe serum concentration of Enalapril can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Enalapril.
KebuzoneThe risk or severity of adverse effects can be increased when Enalapril is combined with Kebuzone.
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Enalapril.
KetoconazoleThe metabolism of Enalapril can be decreased when combined with Ketoconazole.
KetoconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Enalapril.
KetoprofenThe risk or severity of adverse effects can be increased when Enalapril is combined with Ketoprofen.
KetorolacThe risk or severity of adverse effects can be increased when Enalapril is combined with Ketorolac.
LabetalolEnalapril may increase the hypotensive activities of Labetalol.
LacidipineEnalapril may increase the hypotensive activities of Lacidipine.
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Enalapril.
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Enalapril.
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Enalapril.
Lanthanum carbonateThe serum concentration of Enalapril can be decreased when it is combined with Lanthanum carbonate.
LatanoprostEnalapril may increase the hypotensive activities of Latanoprost.
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Enalapril.
LeflunomideThe risk or severity of adverse effects can be increased when Enalapril is combined with Leflunomide.
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Enalapril.
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Enalapril.
LercanidipineLercanidipine may increase the hypotensive activities of Enalapril.
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Enalapril.
LevobunololThe risk or severity of adverse effects can be increased when Enalapril is combined with Levobunolol.
LevodopaEnalapril may increase the orthostatic hypotensive activities of Levodopa.
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Enalapril.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Enalapril.
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Enalapril.
LinagliptinThe risk or severity of adverse effects can be increased when Linagliptin is combined with Enalapril.
LisinoprilEnalapril may increase the hypotensive activities of Lisinopril.
LithiumThe serum concentration of Lithium can be increased when it is combined with Enalapril.
LofexidineEnalapril may increase the hypotensive activities of Lofexidine.
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Enalapril.
LopinavirThe metabolism of Enalapril can be decreased when combined with Lopinavir.
LornoxicamThe risk or severity of adverse effects can be increased when Enalapril is combined with Lornoxicam.
LosartanEnalapril may increase the hypotensive activities of Losartan.
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Enalapril.
LovastatinThe metabolism of Enalapril can be decreased when combined with Lovastatin.
LoxoprofenThe risk or severity of adverse effects can be increased when Enalapril is combined with Loxoprofen.
LuliconazoleThe serum concentration of Enalapril can be increased when it is combined with Luliconazole.
LumiracoxibThe risk or severity of adverse effects can be increased when Enalapril is combined with Lumiracoxib.
MacitentanEnalapril may increase the hypotensive activities of Macitentan.
Magnesium salicylateThe risk or severity of adverse effects can be increased when Enalapril is combined with Magnesium salicylate.
ManidipineEnalapril may increase the hypotensive activities of Manidipine.
MannitolThe risk or severity of adverse effects can be increased when Enalapril is combined with Mannitol.
MasoprocolThe risk or severity of adverse effects can be increased when Enalapril is combined with Masoprocol.
MebanazineMebanazine may increase the hypotensive activities of Enalapril.
MecamylamineEnalapril may increase the hypotensive activities of Mecamylamine.
Meclofenamic acidThe risk or severity of adverse effects can be increased when Enalapril is combined with Meclofenamic acid.
Mefenamic acidThe risk or severity of adverse effects can be increased when Enalapril is combined with Mefenamic acid.
MeloxicamThe risk or severity of adverse effects can be increased when Enalapril is combined with Meloxicam.
MesalazineThe risk or severity of adverse effects can be increased when Enalapril is combined with Mesalazine.
MesalazineMesalazine may decrease the antihypertensive activities of Enalapril.
MetamizoleThe risk or severity of adverse effects can be increased when Enalapril is combined with Metamizole.
MethazolamideThe risk or severity of adverse effects can be increased when Enalapril is combined with Methazolamide.
MethohexitalMethohexital may increase the hypotensive activities of Enalapril.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Enalapril.
MethyclothiazideMethyclothiazide may increase the hypotensive activities of Enalapril.
MethyclothiazideThe risk or severity of adverse effects can be increased when Enalapril is combined with Methyclothiazide.
MethyldopaEnalapril may increase the hypotensive activities of Methyldopa.
Methylene blueMethylene blue may increase the hypotensive activities of Enalapril.
MethylphenidateMethylphenidate may decrease the antihypertensive activities of Enalapril.
MethylphenobarbitalMethylphenobarbital may increase the hypotensive activities of Enalapril.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Enalapril.
MetipranololEnalapril may increase the hypotensive activities of Metipranolol.
MetolazoneMetolazone may increase the hypotensive activities of Enalapril.
MetoprololMetoprolol may increase the hypotensive activities of Enalapril.
MibefradilEnalapril may increase the hypotensive activities of Mibefradil.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Enalapril.
MifepristoneThe metabolism of Enalapril can be decreased when combined with Mifepristone.
MinaprineMinaprine may increase the hypotensive activities of Enalapril.
MinoxidilMinoxidil may increase the hypotensive activities of Enalapril.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Enalapril.
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Enalapril.
MitotaneThe serum concentration of Enalapril can be decreased when it is combined with Mitotane.
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Enalapril.
MoclobemideMoclobemide may increase the hypotensive activities of Enalapril.
ModafinilThe serum concentration of Enalapril can be decreased when it is combined with Modafinil.
MoexiprilEnalapril may increase the hypotensive activities of Moexipril.
MolsidomineMolsidomine may increase the hypotensive activities of Enalapril.
MorphineThe serum concentration of Morphine can be increased when it is combined with Enalapril.
MoxonidineEnalapril may increase the hypotensive activities of Moxonidine.
Mycophenolate mofetilThe risk or severity of adverse effects can be increased when Enalapril is combined with Mycophenolate mofetil.
Mycophenolic acidThe risk or severity of adverse effects can be increased when Enalapril is combined with Mycophenolic acid.
NabumetoneThe risk or severity of adverse effects can be increased when Enalapril is combined with Nabumetone.
NadololEnalapril may increase the hypotensive activities of Nadolol.
NadroparinNadroparin may increase the hyperkalemic activities of Enalapril.
NafcillinThe serum concentration of Enalapril can be decreased when it is combined with Nafcillin.
NaftifineThe risk or severity of adverse effects can be increased when Enalapril is combined with Naftifine.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Enalapril.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Enalapril.
NaproxenThe risk or severity of adverse effects can be increased when Enalapril is combined with Naproxen.
NCX 4016The risk or severity of adverse effects can be increased when Enalapril is combined with NCX 4016.
NebivololEnalapril may increase the hypotensive activities of Nebivolol.
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Enalapril.
NefazodoneThe metabolism of Enalapril can be decreased when combined with Nefazodone.
NelfinavirThe metabolism of Enalapril can be decreased when combined with Nelfinavir.
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Enalapril.
NepafenacThe risk or severity of adverse effects can be increased when Enalapril is combined with Nepafenac.
NesiritideThe risk or severity of adverse effects can be increased when Enalapril is combined with Nesiritide.
NetupitantThe serum concentration of Enalapril can be increased when it is combined with Netupitant.
NevirapineThe metabolism of Enalapril can be decreased when combined with Nevirapine.
NialamideNialamide may increase the hypotensive activities of Enalapril.
NicardipineEnalapril may increase the hypotensive activities of Nicardipine.
NicorandilNicorandil may increase the hypotensive activities of Enalapril.
NifedipineThe risk or severity of adverse effects can be increased when Enalapril is combined with Nifedipine.
Niflumic AcidThe risk or severity of adverse effects can be increased when Enalapril is combined with Niflumic Acid.
NiguldipineEnalapril may increase the hypotensive activities of Niguldipine.
NilotinibThe metabolism of Enalapril can be decreased when combined with Nilotinib.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Enalapril.
NilvadipineEnalapril may increase the hypotensive activities of Nilvadipine.
NimesulideThe risk or severity of adverse effects can be increased when Enalapril is combined with Nimesulide.
NimodipineNimodipine may increase the hypotensive activities of Enalapril.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Enalapril.
NisoldipineNisoldipine may increase the hypotensive activities of Enalapril.
NitrendipineEnalapril may increase the hypotensive activities of Nitrendipine.
NitroglycerinThe risk or severity of adverse effects can be increased when Enalapril is combined with Nitroglycerin.
NitroprussideNitroprusside may increase the hypotensive activities of Enalapril.
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Enalapril.
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Enalapril.
ObinutuzumabEnalapril may increase the hypotensive activities of Obinutuzumab.
OctamoxinOctamoxin may increase the hypotensive activities of Enalapril.
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Enalapril.
OlaparibThe metabolism of Enalapril can be decreased when combined with Olaparib.
OlmesartanOlmesartan may increase the hypotensive activities of Enalapril.
OlopatadineThe risk or severity of adverse effects can be increased when Enalapril is combined with Olopatadine.
OlsalazineThe risk or severity of adverse effects can be increased when Enalapril is combined with Olsalazine.
OmapatrilatEnalapril may increase the hypotensive activities of Omapatrilat.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Enalapril.
OrgoteinThe risk or severity of adverse effects can be increased when Enalapril is combined with Orgotein.
OsimertinibThe serum concentration of Enalapril can be increased when it is combined with Osimertinib.
OxaprozinThe risk or severity of adverse effects can be increased when Enalapril is combined with Oxaprozin.
OxprenololEnalapril may increase the hypotensive activities of Oxprenolol.
OxyphenbutazoneThe risk or severity of adverse effects can be increased when Enalapril is combined with Oxyphenbutazone.
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Enalapril.
PalbociclibThe serum concentration of Enalapril can be increased when it is combined with Palbociclib.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Enalapril.
PapaverineThe risk or severity of adverse effects can be increased when Enalapril is combined with Papaverine.
ParecoxibThe risk or severity of adverse effects can be increased when Enalapril is combined with Parecoxib.
PargylineEnalapril may increase the hypotensive activities of Pargyline.
ParnaparinParnaparin may increase the hyperkalemic activities of Enalapril.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Enalapril.
PenbutololEnalapril may increase the hypotensive activities of Penbutolol.
PentobarbitalPentobarbital may increase the hypotensive activities of Enalapril.
PentoliniumEnalapril may increase the hypotensive activities of Pentolinium.
PentoxifyllinePentoxifylline may increase the hypotensive activities of Enalapril.
PerindoprilEnalapril may increase the hypotensive activities of Perindopril.
PethidineThe risk or severity of adverse effects can be increased when Enalapril is combined with Pethidine.
PhenelzinePhenelzine may increase the hypotensive activities of Enalapril.
PheniprazinePheniprazine may increase the hypotensive activities of Enalapril.
PhenobarbitalPhenobarbital may increase the hypotensive activities of Enalapril.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Enalapril.
PhenoxybenzamineEnalapril may increase the hypotensive activities of Phenoxybenzamine.
PhenoxypropazinePhenoxypropazine may increase the hypotensive activities of Enalapril.
PhentolamineEnalapril may increase the hypotensive activities of Phentolamine.
PhenylbutazoneThe risk or severity of adverse effects can be increased when Enalapril is combined with Phenylbutazone.
PhenytoinThe metabolism of Enalapril can be increased when combined with Phenytoin.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Enalapril.
PimecrolimusThe risk or severity of adverse effects can be increased when Enalapril is combined with Pimecrolimus.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Enalapril.
PinacidilEnalapril may increase the hypotensive activities of Pinacidil.
PindololEnalapril may increase the hypotensive activities of Pindolol.
PiretanidePiretanide may increase the hypotensive activities of Enalapril.
PirfenidoneThe risk or severity of adverse effects can be increased when Enalapril is combined with Pirfenidone.
PirlindolePirlindole may increase the hypotensive activities of Enalapril.
PiroxicamThe risk or severity of adverse effects can be increased when Enalapril is combined with Piroxicam.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Enalapril.
PivhydrazinePivhydrazine may increase the hypotensive activities of Enalapril.
PolythiazideEnalapril may increase the hypotensive activities of Polythiazide.
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Enalapril.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Enalapril.
PosaconazoleThe metabolism of Enalapril can be decreased when combined with Posaconazole.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Enalapril.
PrazosinPrazosin may increase the hypotensive activities of Enalapril.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Enalapril.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Enalapril.
PregabalinThe risk or severity of adverse effects can be increased when Enalapril is combined with Pregabalin.
PrimidonePrimidone may increase the hypotensive activities of Enalapril.
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Enalapril.
PropacetamolThe risk or severity of adverse effects can be increased when Enalapril is combined with Propacetamol.
PropranololPropranolol may increase the hypotensive activities of Enalapril.
ProtriptylineThe serum concentration of Protriptyline can be increased when it is combined with Enalapril.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Enalapril.
PTC299The risk or severity of adverse effects can be increased when Enalapril is combined with PTC299.
QuetiapineThe risk or severity of adverse effects can be increased when Enalapril is combined with Quetiapine.
QuinaprilEnalapril may increase the hypotensive activities of Quinapril.
QuinethazoneQuinethazone may increase the hypotensive activities of Enalapril.
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Enalapril.
QuinineQuinine may increase the hypotensive activities of Enalapril.
QuinineThe serum concentration of Quinine can be increased when it is combined with Enalapril.
RamiprilRamipril may increase the hypotensive activities of Enalapril.
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Enalapril.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Enalapril.
RanolazineThe metabolism of Enalapril can be decreased when combined with Ranolazine.
RasagilineRasagiline may increase the hypotensive activities of Enalapril.
RemikirenRemikiren may increase the hypotensive activities of Enalapril.
RescinnamineEnalapril may increase the hypotensive activities of Rescinnamine.
ReserpineReserpine may increase the hypotensive activities of Enalapril.
ResveratrolThe risk or severity of adverse effects can be increased when Enalapril is combined with Resveratrol.
ReviparinReviparin may increase the hyperkalemic activities of Enalapril.
RifabutinThe metabolism of Enalapril can be increased when combined with Rifabutin.
RifampicinThe metabolism of Enalapril can be increased when combined with Rifampicin.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Enalapril.
RifapentineThe metabolism of Enalapril can be increased when combined with Rifapentine.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Enalapril.
RiociguatEnalapril may increase the hypotensive activities of Riociguat.
RisperidoneEnalapril may increase the hypotensive activities of Risperidone.
RitonavirThe metabolism of Enalapril can be decreased when combined with Ritonavir.
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Enalapril.
RituximabEnalapril may increase the hypotensive activities of Rituximab.
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Enalapril.
RofecoxibThe risk or severity of adverse effects can be increased when Enalapril is combined with Rofecoxib.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Enalapril.
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Enalapril.
SacubitrilThe risk or severity of adverse effects can be increased when Enalapril is combined with Sacubitril.
SafrazineSafrazine may increase the hypotensive activities of Enalapril.
SalicylamideThe risk or severity of adverse effects can be increased when Enalapril is combined with Salicylamide.
Salicylic acidThe risk or severity of adverse effects can be increased when Enalapril is combined with Salicylic acid.
Salicylic acidSalicylic acid may decrease the antihypertensive activities of Enalapril.
SalsalateThe risk or severity of adverse effects can be increased when Enalapril is combined with Salsalate.
SaprisartanEnalapril may increase the hypotensive activities of Saprisartan.
SaquinavirThe metabolism of Enalapril can be decreased when combined with Saquinavir.
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Enalapril.
SaralasinThe risk or severity of adverse effects can be increased when Saralasin is combined with Enalapril.
SaxagliptinThe risk or severity of adverse effects can be increased when Saxagliptin is combined with Enalapril.
SecobarbitalSecobarbital may increase the hypotensive activities of Enalapril.
SelegilineSelegiline may increase the hypotensive activities of Enalapril.
SelexipagEnalapril may increase the hypotensive activities of Selexipag.
SeratrodastThe risk or severity of adverse effects can be increased when Enalapril is combined with Seratrodast.
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Enalapril.
SildenafilSildenafil may increase the antihypertensive activities of Enalapril.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Enalapril.
SiltuximabThe serum concentration of Enalapril can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Enalapril can be increased when it is combined with Simeprevir.
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Enalapril.
SirolimusThe risk or severity of adverse effects can be increased when Sirolimus is combined with Enalapril.
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Enalapril.
SitagliptinThe risk or severity of adverse effects can be increased when Sitagliptin is combined with Enalapril.
SitaxentanEnalapril may increase the hypotensive activities of Sitaxentan.
Sodium aurothiomalateThe risk or severity of adverse effects can be increased when Enalapril is combined with Sodium aurothiomalate.
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Enalapril.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Enalapril.
SotalolThe risk or severity of adverse effects can be increased when Sotalol is combined with Enalapril.
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Enalapril.
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Enalapril.
SpiraprilEnalapril may increase the hypotensive activities of Spirapril.
SpironolactoneThe risk or severity of adverse effects can be increased when Spironolactone is combined with Enalapril.
SRT501The risk or severity of adverse effects can be increased when Enalapril is combined with SRT501.
St. John's WortThe metabolism of Enalapril can be increased when combined with St. John&#39;s Wort.
StiripentolThe serum concentration of Enalapril can be increased when it is combined with Stiripentol.
SulfasalazineThe risk or severity of adverse effects can be increased when Enalapril is combined with Sulfasalazine.
SulfisoxazoleThe metabolism of Enalapril can be decreased when combined with Sulfisoxazole.
SulindacThe risk or severity of adverse effects can be increased when Enalapril is combined with Sulindac.
SuprofenThe risk or severity of adverse effects can be increased when Enalapril is combined with Suprofen.
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Enalapril.
TadalafilTadalafil may increase the antihypertensive activities of Enalapril.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Enalapril.
TasosartanThe risk or severity of adverse effects can be increased when Tasosartan is combined with Enalapril.
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Enalapril.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Enalapril.
TelaprevirThe metabolism of Enalapril can be decreased when combined with Telaprevir.
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Enalapril.
TelithromycinThe metabolism of Enalapril can be decreased when combined with Telithromycin.
TelmisartanEnalapril may increase the hypotensive activities of Telmisartan.
TemocaprilEnalapril may increase the hypotensive activities of Temocapril.
TemsirolimusThe risk or severity of adverse effects can be increased when Temsirolimus is combined with Enalapril.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Enalapril.
TenoxicamThe risk or severity of adverse effects can be increased when Enalapril is combined with Tenoxicam.
TepoxalinThe risk or severity of adverse effects can be increased when Enalapril is combined with Tepoxalin.
TerazosinThe risk or severity of adverse effects can be increased when Enalapril is combined with Terazosin.
TeriflunomideThe risk or severity of adverse effects can be increased when Enalapril is combined with Teriflunomide.
TerlipressinEnalapril may increase the hypotensive activities of Terlipressin.
TheophyllineThe serum concentration of Theophylline can be decreased when it is combined with Enalapril.
ThiamylalThiamylal may increase the hypotensive activities of Enalapril.
ThiopentalThiopental may increase the hypotensive activities of Enalapril.
TianeptineThe serum concentration of Tianeptine can be increased when it is combined with Enalapril.
Tiaprofenic acidThe risk or severity of adverse effects can be increased when Enalapril is combined with Tiaprofenic acid.
TiboloneEnalapril may increase the hypotensive activities of Tibolone.
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Enalapril.
TiclopidineThe metabolism of Enalapril can be decreased when combined with Ticlopidine.
TicrynafenEnalapril may increase the hypotensive activities of Ticrynafen.
TimololTimolol may increase the hypotensive activities of Enalapril.
TinzaparinTinzaparin may increase the hyperkalemic activities of Enalapril.
TipranavirThe serum concentration of Enalapril can be decreased when it is combined with Tipranavir.
TizanidineTizanidine may increase the hypotensive activities of Enalapril.
TizanidineThe risk or severity of adverse effects can be increased when Enalapril is combined with Tizanidine.
TocilizumabThe serum concentration of Enalapril can be decreased when it is combined with Tocilizumab.
TolazolineEnalapril may increase the hypotensive activities of Tolazoline.
Tolfenamic AcidThe risk or severity of adverse effects can be increased when Enalapril is combined with Tolfenamic Acid.
TolmetinThe risk or severity of adverse effects can be increased when Enalapril is combined with Tolmetin.
ToloxatoneToloxatone may increase the hypotensive activities of Enalapril.
TolvaptanTolvaptan may increase the hyperkalemic activities of Enalapril.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Enalapril.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Enalapril.
TorasemideTorasemide may increase the hypotensive activities of Enalapril.
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Enalapril.
TrandolaprilTrandolapril may increase the hypotensive activities of Enalapril.
TranilastThe risk or severity of adverse effects can be increased when Enalapril is combined with Tranilast.
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the hypotensive activities of Enalapril.
TranylcypromineTranylcypromine may increase the hypotensive activities of Enalapril.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Enalapril.
TravoprostTravoprost may increase the hypotensive activities of Enalapril.
TreprostinilTreprostinil may increase the hypotensive activities of Enalapril.
TriamtereneThe risk or severity of adverse effects can be increased when Triamterene is combined with Enalapril.
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Enalapril.
TrichlormethiazideEnalapril may increase the hypotensive activities of Trichlormethiazide.
TrimazosinEnalapril may increase the hypotensive activities of Trimazosin.
TrimethaphanEnalapril may increase the hypotensive activities of Trimethaphan.
TrimethoprimTrimethoprim may increase the hyperkalemic activities of Enalapril.
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Enalapril.
Trisalicylate-cholineThe risk or severity of adverse effects can be increased when Enalapril is combined with Trisalicylate-choline.
UdenafilUdenafil may increase the antihypertensive activities of Enalapril.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Enalapril.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Enalapril.
UnoprostoneEnalapril may increase the hypotensive activities of Unoprostone.
ValdecoxibThe risk or severity of adverse effects can be increased when Enalapril is combined with Valdecoxib.
ValsartanValsartan may increase the hypotensive activities of Enalapril.
VardenafilVardenafil may increase the antihypertensive activities of Enalapril.
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Enalapril.
VenlafaxineThe metabolism of Enalapril can be decreased when combined with Venlafaxine.
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Enalapril.
VerapamilThe risk or severity of adverse effects can be increased when Enalapril is combined with Verapamil.
VildagliptinThe risk or severity of adverse effects can be increased when Vildagliptin is combined with Enalapril.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Enalapril.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Enalapril.
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Enalapril.
VoriconazoleThe metabolism of Enalapril can be decreased when combined with Voriconazole.
XylometazolineEnalapril may increase the hypotensive activities of Xylometazoline.
YohimbineYohimbine may decrease the antihypertensive activities of Enalapril.
ZaltoprofenThe risk or severity of adverse effects can be increased when Enalapril is combined with Zaltoprofen.
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Enalapril.
ZileutonThe risk or severity of adverse effects can be increased when Enalapril is combined with Zileuton.
ZiprasidoneThe metabolism of Enalapril can be decreased when combined with Ziprasidone.
ZomepiracThe risk or severity of adverse effects can be increased when Enalapril is combined with Zomepirac.
Food Interactions
  • Enalapril decreases the excretion of potassium. Salt substitutes containing potassium increase the risk of hyperkalemia.
  • Herbs that may attenuate the antihypertensive effect of enalapril include: bayberry, blue cohash, cayenne, ephedra, ginger, ginseng (American), kola and licorice.
  • High salt intake may attenuate the antihypertensive effect of enalapril.
  • Take without regard to meals.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Zinc ion binding
Specific Function:
Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.
Gene Name:
ACE
Uniprot ID:
P12821
Molecular Weight:
149713.675 Da
References
  1. Andujar-Sanchez M, Jara-Perez V, Camara-Artigas A: Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method. FEBS Lett. 2007 Jul 24;581(18):3449-54. Epub 2007 Jun 27. [PubMed:17618628 ]
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  3. Liu YH, Liu LY, Wu JX, Chen SX, Sun YX: Comparison of captopril and enalapril to study the role of the sulfhydryl-group in improvement of endothelial dysfunction with ACE inhibitors in high dieted methionine mice. J Cardiovasc Pharmacol. 2006 Jan;47(1):82-8. [PubMed:16424790 ]
  4. Natesh R, Schwager SL, Evans HR, Sturrock ED, Acharya KR: Structural details on the binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensin I-converting enzyme. Biochemistry. 2004 Jul 13;43(27):8718-24. [PubMed:15236580 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Takara K, Kakumoto M, Tanigawara Y, Funakoshi J, Sakaeda T, Okumura K: Interaction of digoxin with antihypertensive drugs via MDR1. Life Sci. 2002 Feb 15;70(13):1491-500. [PubMed:11895100 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Proton-dependent oligopeptide secondary active transmembrane transporter activity
Specific Function:
Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products.
Gene Name:
SLC15A1
Uniprot ID:
P46059
Molecular Weight:
78805.265 Da
References
  1. Han H, de Vrueh RL, Rhie JK, Covitz KM, Smith PL, Lee CP, Oh DM, Sadee W, Amidon GL: 5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter. Pharm Res. 1998 Aug;15(8):1154-9. [PubMed:9706043 ]
  2. Han HK, Rhie JK, Oh DM, Saito G, Hsu CP, Stewart BH, Amidon GL: CHO/hPEPT1 cells overexpressing the human peptide transporter (hPEPT1) as an alternative in vitro model for peptidomimetic drugs. J Pharm Sci. 1999 Mar;88(3):347-50. [PubMed:10052994 ]
  3. Temple CS, Boyd CA: Proton-coupled oligopeptide transport by rat renal cortical brush border membrane vesicles: a functional analysis using ACE inhibitors to determine the isoform of the transporter. Biochim Biophys Acta. 1998 Aug 14;1373(1):277-81. [PubMed:9733984 ]
  4. Tsuji A: Transporter-mediated Drug Interactions. Drug Metab Pharmacokinet. 2002;17(4):253-74. [PubMed:15618677 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-in...
Gene Name:
SLC22A6
Uniprot ID:
Q4U2R8
Molecular Weight:
61815.78 Da
References
  1. Kuze K, Graves P, Leahy A, Wilson P, Stuhlmann H, You G: Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells. J Biol Chem. 1999 Jan 15;274(3):1519-24. [PubMed:9880528 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).
Gene Name:
SLC22A8
Uniprot ID:
Q8TCC7
Molecular Weight:
59855.585 Da
References
  1. Kobayashi Y, Ohshiro N, Tsuchiya A, Kohyama N, Ohbayashi M, Yamamoto T: Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3. Drug Metab Dispos. 2004 May;32(5):479-83. [PubMed:15100168 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate.
Gene Name:
SLC22A7
Uniprot ID:
Q9Y694
Molecular Weight:
60025.025 Da
References
  1. Kobayashi Y, Ohshiro N, Shibusawa A, Sasaki T, Tokuyama S, Sekine T, Endou H, Yamamoto T: Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice. Mol Pharmacol. 2002 Jul;62(1):7-14. [PubMed:12065749 ]
  2. Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H: Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett. 1998 Jun 12;429(2):179-82. [PubMed:9650585 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. Abu-Zahra TN, Wolkoff AW, Kim RB, Pang KS: Uptake of enalapril and expression of organic anion transporting polypeptide 1 in zonal, isolated rat hepatocytes. Drug Metab Dispos. 2000 Jul;28(7):801-6. [PubMed:10859154 ]
  2. Pang KS, Wang PJ, Chung AY, Wolkoff AW: The modified dipeptide, enalapril, an angiotensin-converting enzyme inhibitor, is transported by the rat liver organic anion transport protein. Hepatology. 1998 Nov;28(5):1341-6. [PubMed:9794920 ]
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Drug created on June 13, 2005 07:24 / Updated on September 30, 2016 02:27