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Identification
NameNitroglycerin
Accession NumberDB00727  (APRD00153)
TypeSmall Molecule
GroupsApproved, Investigational
Description

A volatile vasodilator which relieves angina pectoris by stimulating guanylate cyclase and lowering cytosolic calcium. [PubChem]

Structure
Thumb
Synonyms
SynonymLanguageCode
1,2,3-PropanetrioltrinitrateNot AvailableNot Available
1,2,3-Propanetriyl nitrateNot AvailableNot Available
Glycerin trinitrateNot AvailableNot Available
Glycerol trinitrateNot AvailableNot Available
Glycerol, nitric acid triesterNot AvailableNot Available
Glyceroli trinitratis LatinINN
GlyceroltrinitratGermanINN
Glyceryl trinitrateNot AvailableNot Available
MinitranNot AvailableNot Available
NatisprayNot AvailableNot Available
NGNot AvailableNot Available
Nitro-durNot AvailableNot Available
NitroglicerinaNot AvailablePH: F.U. XII
NitroglycerinNot AvailableNot Available
NitroglycerineNot AvailableNot Available
NitroglycerolNot AvailableIS
NitrolingualNot AvailableNot Available
NitromedNot AvailableIS
NitromistNot AvailableNot Available
NitrostatNot AvailableNot Available
Propane-1,2,3-triyl trinitrateNot AvailableNot Available
RectogesicNot AvailableNot Available
Transderm nitroNot AvailableNot Available
TrinitrineFrenchINN
TrinitroglycerinNot AvailableNot Available
TrinitroglycerolNot AvailableNot Available
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Nitrostattablet.3 mgsublingualParke Davis Div Of Pfizer Inc2000-05-01Not AvailableUs
Nitrostattablet.4 mgsublingualParke Davis Div Of Pfizer Inc2000-05-01Not AvailableUs
Nitrostattablet.6 mgsublingualParke Davis Div Of Pfizer Inc2000-05-01Not AvailableUs
Nitro-durpatch160 mgtransdermalMerck Sharp & Dohme Corp.1995-04-04Not AvailableUs
Nitro-durpatch20 mgtransdermalMerck Sharp & Dohme Corp.1995-04-04Not AvailableUs
Nitro-durpatch40 mgtransdermalMerck Sharp & Dohme Corp.1995-04-04Not AvailableUs
Nitro-durpatch60 mgtransdermalMerck Sharp & Dohme Corp.1995-04-04Not AvailableUs
Nitro-durpatch80 mgtransdermalMerck Sharp & Dohme Corp.1995-04-04Not AvailableUs
Nitro-durpatch120 mgtransdermalMerck Sharp & Dohme Corp.1995-04-04Not AvailableUs
Nitrostattablet.4 mgsublingualRebel Distributors Corp2000-05-01Not AvailableUs
Nitrolingualspray400 ugoralRebel Distributors Corp1985-10-31Not AvailableUs
Nitromistaerosol, metered400 ugsublingualAkrimax Pharmaceuticals, LLC2010-05-01Not AvailableUs
Nitrolingual Pumpsprayspray, metered400 ugoralArbor Pharmaceuticals, Inc.2000-02-01Not AvailableUs
Rectivointment4 mg/grectalPro Strakan, Inc.2011-06-21Not AvailableUs
Nitroglycerinaerosol, metered400 ugsublingualRouses Point Pharm2012-10-16Not AvailableUs
Nitrostattablet.4 mgsublingualREMEDYREPACK INC.2013-12-05Not AvailableUs
Nitrostattablet.4 mgsublingualREMEDYREPACK INC.2015-01-02Not AvailableUs
Nitrostattablet.4 mgoralREMEDYREPACK INC.2012-03-02Not AvailableUs
Nitrostattablet.4 mgsublingualA S Medication Solutions Llc2000-05-01Not AvailableUs
Nitrostattablet.4 mgsublingualA S Medication Solutions Llc2000-05-01Not AvailableUs
Nitrostattablet.4 mgsublingualREMEDYREPACK INC.2013-05-13Not AvailableUs
Nitroglycerin Lingualspray, metered400 ugoralWilshire Pharmaceuticals, Inc.2011-02-01Not AvailableUs
Nitrostattablet.4 mgoralGeneral Injectables & Vaccines, Inc2010-03-01Not AvailableUs
Nitrostattablet.4 mgsublingualAidarex Pharmaceuticals LLC2000-05-01Not AvailableUs
Nitrostattablet.4 mgsublingualA S Medication Solutions Llc2000-05-01Not AvailableUs
Nitrostattablet.4 mgsublingualA S Medication Solutions Llc2000-05-01Not AvailableUs
Nitrostattablet.4 mgoralPhysicians Total Care, Inc.1995-08-11Not AvailableUs
Nitrostattablet.3 mgoralPhysicians Total Care, Inc.1994-09-22Not AvailableUs
Nitroglycerintablet, orally disintegrating.4 mgsublingualPhysicians Total Care, Inc.2009-06-25Not AvailableUs
Nitrostattablet.4 mgsublingualCardinal Health2000-05-01Not AvailableUs
Rectivointment4 mg/grectalAptalis Pharma US, Inc.2011-06-21Not AvailableUs
Nitroglycerintablet, orally disintegrating.6 mgsublingualGreenstone LLC2003-04-08Not AvailableUs
Nitroglycerintablet, orally disintegrating.4 mgsublingualGreenstone LLC2003-04-08Not AvailableUs
Nitroglycerintablet, orally disintegrating.3 mgsublingualGreenstone LLC2003-04-08Not AvailableUs
Nitrostattablet.4 mgsublingualPreferred Pharmaceuticals, Inc.2013-05-15Not AvailableUs
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Nitro-bidointment20 mg/gtopicalE. FOUGERA & CO., A division of Nycomed US Inc.2009-08-15Not AvailableUs
Nitro-bidointment20 mg/gtopicalSavage Laboratories a division of Fougera Pharmaceuticals Inc.2009-08-15Not AvailableUs
Nitroglycerinpatch.1 mg/htransdermalMylan Pharmaceuticals Inc.2011-09-19Not AvailableUs
Nitroglycerinpatch.2 mg/htransdermalMylan Pharmaceuticals Inc.2011-09-19Not AvailableUs
Nitroglycerinpatch.4 mg/htransdermalMylan Pharmaceuticals Inc.2011-09-19Not AvailableUs
Nitroglycerinpatch.6 mg/htransdermalMylan Pharmaceuticals Inc.2011-09-19Not AvailableUs
Nitroglycerininjection, solution5 mg/mLintravenousAmerican Regent, Inc.2003-03-04Not AvailableUs
Nitroglycerin Transdermal Systempatch.2 mg/htransdermalHarvard Drug Group, LLC1998-10-30Not AvailableUs
Nitroglycerin Transdermal Systempatch.4 mg/htransdermalHarvard Drug Group, LLC1998-10-30Not AvailableUs
Nitroglycerin Transdermal Systempatch.6 mg/htransdermalHarvard Drug Group, LLC1998-10-30Not AvailableUs
Minitranpatch2.5 mg/dtransdermalGraceway Pharmaceuticals, LLC2007-04-01Not AvailableUs
Minitranpatch5 mg/dtransdermalGraceway Pharmaceuticals, LLC2007-04-01Not AvailableUs
Minitranpatch10 mg/dtransdermalGraceway Pharmaceuticals, LLC2009-08-10Not AvailableUs
Minitranpatch15 mg/dtransdermalGraceway Pharmaceuticals, LLC2007-04-01Not AvailableUs
Nitroglycerin Transdermal Delivery Systempatch2.5 mg/dtransdermalGraceway Pharmaceuticals, LLC2007-04-01Not AvailableUs
Nitroglycerin Transdermal Delivery Systempatch5 mg/dtransdermalGraceway Pharmaceuticals, LLC2007-04-01Not AvailableUs
Nitroglycerin Transdermal Delivery Systempatch10 mg/dtransdermalGraceway Pharmaceuticals, LLC2007-04-04Not AvailableUs
Nitroglycerin Transdermal Delivery Systempatch15 mg/dtransdermalGraceway Pharmaceuticals, LLC2007-04-01Not AvailableUs
Nitroglycerin Lingualspray400 ugoralPerrigo New York Inc2013-09-20Not AvailableUs
Nitroglycerin Transdermal Delivery Systempatch.1 mg/htransdermalAlvogen, Inc.2010-11-10Not AvailableUs
Nitroglycerin Transdermal Delivery Systempatch.2 mg/htransdermalAlvogen, Inc.2010-11-10Not AvailableUs
Nitroglycerin Transdermal Delivery Systempatch.4 mg/htransdermalAlvogen, Inc.2010-11-10Not AvailableUs
Nitroglycerin Transdermal Delivery Systempatch.6 mg/htransdermalAlvogen, Inc.2010-11-10Not AvailableUs
Nitroglycerin Transdermal Systempatch.2 mg/htransdermalHercon Laboratories Corporation1998-10-30Not AvailableUs
Nitroglycerin Transdermal Systempatch.4 mg/htransdermalHercon Laboratories Corporation1998-10-30Not AvailableUs
Nitroglycerin Transdermal Systempatch.6 mg/htransdermalHercon Laboratories Corporation1998-10-30Not AvailableUs
Nitroglycerin Transdermal Delivery Systempatch10 mg/dtransdermalPhysicians Total Care, Inc.2004-10-27Not AvailableUs
Nitroglycerin Transdermal Delivery Systempatch5 mg/dtransdermalPhysicians Total Care, Inc.2004-10-12Not AvailableUs
Nitroglycerin Transdermal Delivery Systempatch2.5 mg/dtransdermalPhysicians Total Care, Inc.2006-05-30Not AvailableUs
Nitroglycerin Transdermal Systempatch.2 mg/htransdermalCardinal Health1998-10-30Not AvailableUs
Nitroglycerinfilm, extended release20.8 mgtransdermalKremers Urban Pharmaceuticals Inc.2004-08-10Not AvailableUs
Nitroglycerinfilm, extended release37.4 mgtransdermalKremers Urban Pharmaceuticals Inc.2004-08-10Not AvailableUs
Nitroglycerin ERcapsule2.5 mgoralPd Rx Pharmaceuticals, Inc.2010-05-10Not AvailableUs
Nitroglycerin ERcapsule6.5 mgoralPd Rx Pharmaceuticals, Inc.2010-05-10Not AvailableUs
Nitroglycerin ERcapsule9 mgoralPd Rx Pharmaceuticals, Inc.2010-05-10Not AvailableUs
Minitranpatch9 mgtransdermalMedicis Pharmaceutical Corp2012-02-21Not AvailableUs
Minitranpatch18 mgtransdermalMedicis Pharmaceutical Corp2012-02-21Not AvailableUs
Minitranpatch36 mgtransdermalMedicis Pharmaceutical Corp2012-02-21Not AvailableUs
Minitranpatch54 mgtransdermalMedicis Pharmaceutical Corp2012-02-21Not AvailableUs
Over the Counter ProductsNot Available
International Brands
NameCompany
DeponitUCB Pharma
DermatransBayer
Gen-NitroGenpharm ULC
GlytrinSanofi-Aventis
Glytrin SpraySanofi-Aventis
NatisprayTeofarma
NitrocapOrion
Nitroderm TTSNovartis
Nitrolingual Pump SprayArbor Pharmaceuticals
RectogesicProStrakan
RhotrimineNot Available
StangylNot Available
Transderm-NitroNovartis
TridilNot Available
TrimonitSanofi-Aventis
TrinipatchPaladin
TriniplasNovartis
TrinispraySanofi Aventis
Trinitrin Simplex LaleufSanofi
TrinitronQuesada
TrinitrosanMerck
TrintekGoldshield
TrocerIncepta
Trocer SRIncepta
VasolatorSanwa Kagaku
VasovinTorrent
VenitrinMeda
VerniesParke Davis
WilllongWill-Pharma
Brand mixtures
Brand NameIngredients
Alchemed NP-03aconite + apis mellifica + arnica montana + barberry root + calendula + cantharides + charcoal activated + echinacea angustifolia + hahnemann's causticum + hypericum perforatum + nitroglycerin + urtica urens
Alchemed NP-04aesculus hippocastanum + arnica montana + barium carbonate + belladonna + celandine + cinchona officinalis + nitroglycerin + oyster shells + sepia officinalis l + strophanthus hispidus
Alchemed NP-21belladonna + cantharides + german chamomile + nitroglycerin + phosphorus + sepia officinalis l + silver nitrate + valerian + zinc
Aribosan B31 - liqapis mellifica + barberry root + colchicine + convallaria majalis + nitroglycerin + poison oak + potassium iodide + quinine dihyrochloride
Cactus Compositum DPScactus grandiflorus + nitroglycerin + potassium carbonate + spigelia
CafinitrinaNitroglycerin and Caffeine
Cere Bosan B36 - liqbelladonna + hamamelis virginiana + nitroglycerin + saffron + trillium pendulum
Complex 12aesculus hippocastanum + apis mellifica + arnica montana + barium carbonate + barium chloride + belladonna + calcium fluoride + celandine + charcoal activated + cinchona officinalis + collinsonia canadensis + conium maculatum + echinacea angustifolia + hamamelis virginiana + lycopodium clavatum + nitroglycerin + phosphorus + ruta graveolens + sepia officinalis l + sodium chloride + strophanthus hispidus + sulfur + tobacco
Complex 15belladonna + cimicifuga racemosa + cinchona officinalis + glycyrrhiza glabra + nitroglycerin + oyster shells + platinum + pulsatilla + sanguinaria canadensis + sepia officinalis l + sulfur + tiger lily + vitex agnus castus
CRC-plexarnica montana + barium chloride + calcium lactate + charcoal activated + cholesterol + convallaria majalis + epinephrine + iodine + magnesium carbonate + nitroglycerin + phosphorus + picric acid + potassium iodide + strophanthus hispidus
Ero-bosan B20-liqnitroglycerin + pulsatilla + sanguinaria canadensis + sepia officinalis l + vitex agnus castus
From time to timebelladonna + bryonia + charcoal activated + gelsemium sempervirens + lycopodium clavatum + melilot + nitroglycerin + silicon dioxide + sodium chloride + spigelia marylandica
Globuli no 51barium carbonate + cactus grandiflorus + gelsemium sempervirens + nitroglycerin
Homeo-form MI - liquidaluminum oxide + antimony trisulfide + cyclamen europaeum l. + lycopodium clavatum + melilot + nitroglycerin + silver nitrate
Homeo-form MI-tabaluminum oxide + antimony trisulfide + cyclamen europaeum l. + lycopodium clavatum + melilot + nitroglycerin + silver nitrate
Homeodel 24belladonna + charcoal activated + gelsemium sempervirens + iris versicolor + lycopodium + nitroglycerin + spigelia
Homeopathic Remedy THC no.4aconite + arnica montana + belladonna + bryonia + cocculus indicus + gelsemium sempervirens + iris versicolor + lycopodium clavatum + nitroglycerin + potassium dichromate + pulsatilla + sanguinaria canadensis + silicon dioxide + silver nitrate + sodium chloride + spigelia marylandica + thuja occidentalis
HPB Complex DPSbarium chloride + gold + mistletoe + nitroglycerin
Ingr-bosan b34 - liqbelladonna + cimicifuga racemosa + gelsemium sempervirens + iris versicolor + nitroglycerin + spigelia anthelmia
Iper-bosan b44 - liqbaryta iodata + cactus grandiflorus + gelsemium sempervirens + nitroglycerin
L.122 - liq orlbryonia + cactus grandiflorus + nitroglycerin + potassium carbonate
L.15 DPSaconitinum + apocynum cannabinum + arnica montana + cactus grandiflorus + nitroglycerin
L.73 liqbelladonna + cocculus indicus + lead acetate + mugwort + nitroglycerin + periwinkle + pulsatilla + silver nitrate + valerian
L2apis mellifica + belladonna + juglans cinerea + nitroglycerin + phytolacca decandra + pulsatilla + spongia tosta + vitex agnus castus
Nova - 7041 - liqbelladonna + cantharides + german chamomile + nitroglycerin + phosphorus + sepia officinalis l + silver nitrate + valerian + zinc
Nova 7025 - liqaconite + apis mellifica + arnica montana + barberry root + calendula + cantharides + charcoal activated + echinacea angustifolia + hahnemann's causticum + hypericum perforatum + nitroglycerin + urtica urens
Nova 7028 - liqaesculus hippocastanum + arnica montana + barium carbonate + belladonna + calcium carbonate + celandine + cinchona officinalis + nitroglycerin + sepia officinalis l + strophanthus hispidus
Nova 7037 - liqbelladonna + calcium carbonate + cinchona officinalis + nitroglycerin + platinum + pulsatilla + sanguinaria canadensis + sulfur + tiger lily + tin
Pekana - complex nr. 47clematis erecta + cynara scolymus + dulcamara + euphrasia officinalis + ivy + nitroglycerin + ruta graveolens + tobacco
R 47 dpsasafetida + coffee + musk + nitroglycerin + pulsatilla
R-12 dpsarnica montana + barium chloride + calcium iodide + conium maculatum + lead acetate + nitroglycerin + phosphorus + potassium iodide
R12arnica montana + barium chloride + calcium iodide + conium maculatum + lead acetate + nitroglycerin + phosphorus + potassium iodide
R47asafetida + coffee + musk + nitroglycerin + pulsatilla
THC complex #15belladonna + cinchona officinalis + gelsemium sempervirens + nitroglycerin + sodium chloride + sulfur
THC complex #2aconite + apis mellifica + arnica montana + belladonna + bryonia + cocculus indicus + ferrum phosphoricum + gelsemium sempervirens + hydrastis canadensis + iris versicolor + lycopodium clavatum + magnesium phosphate dibasic + nitroglycerin + phosphorus + potassium dichromate + potassium phosphate dibasic + pulsatilla + sanguinaria canadensis + silicon dioxide + silver nitrate + sodium chloride + spigelia marylandica + thuja occidentalis
THC complex #37aconite + bellis perennis + caulophyllum thalictroides + cimicifuga racemosa + nitroglycerin + pulsatilla + sanguinaria canadensis + strontium carbonate
SaltsNot Available
Categories
CAS number55-63-0
WeightAverage: 227.0865
Monoisotopic: 227.002578773
Chemical FormulaC3H5N3O9
InChI KeySNIOPGDIGTZGOP-UHFFFAOYSA-N
InChI
InChI=1S/C3H5N3O9/c7-4(8)13-1-3(15-6(11)12)2-14-5(9)10/h3H,1-2H2
IUPAC Name
1,3-bis(nitrooxy)propan-2-yl nitrate
SMILES
[O-][N+](=O)OCC(CO[N+]([O-])=O)O[N+]([O-])=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as nitrate esters. These are compounds containing a nitrate ester functional group, with the general structure RON+(=O)O, (R cannot be a hydrogen).
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassOrganic nitric acids and derivatives
Sub ClassNitrate esters
Direct ParentNitrate esters
Alternative Parents
Substituents
  • Alkyl nitrate
  • Organic nitrate
  • Nitrate ester
  • Organic nitro compound
  • Organic 1,3-dipolar compound
  • Allyl-type 1,3-dipolar organic compound
  • Hydrocarbon derivative
  • Organic salt
  • Organooxygen compound
  • Organic zwitterion
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Pharmacology
IndicationFor the prevention of angina
PharmacodynamicsNitroglycerin, an organic nitrate, is available in many forms as a vasodilator. Nitroglycerin is used in the treatement of angina pectoris and perioperative hypertension, to produce controlled hypotension during surgical procedures, to treat hypertensive emergencies, and to treat congestive heart failure associated with myocardial infarction.
Mechanism of actionSimilar to other nitrites and organic nitrates, nitroglycerin is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase. This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.
AbsorptionNot Available
Volume of distribution
  • 3 L/kg
Protein bindingNot Available
Metabolism

Hepatic, cytochrome P450 (P450) is a key enzyme of organic nitrate biotransformation

Route of eliminationNot Available
Half life3 minutes
Clearance
  • 1 L/kg/min
ToxicityIncreased intracranial pressure, with any or all of persistent throbbing headache, confusion, and moderate fever; Vertigo; Palpitations; Visual disturbances; Nausea and vomiting (possibly with colic and even bloody diarrhea); Syncope (especially in the upright posture); Air hunger and dyspnea, later followed by reduced ventilatory effort; Diaphoresis, with the skin either flushed or cold and clammy; Heart block and bradycardia; Paralysis; Coma; Seizures; Death.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.7613
Blood Brain Barrier+0.9113
Caco-2 permeable-0.5775
P-glycoprotein substrateNon-substrate0.8322
P-glycoprotein inhibitor INon-inhibitor0.671
P-glycoprotein inhibitor IINon-inhibitor0.9005
Renal organic cation transporterNon-inhibitor0.8325
CYP450 2C9 substrateNon-substrate0.8982
CYP450 2D6 substrateNon-substrate0.9022
CYP450 3A4 substrateNon-substrate0.5255
CYP450 1A2 substrateNon-inhibitor0.8022
CYP450 2C9 substrateNon-inhibitor0.7789
CYP450 2D6 substrateNon-inhibitor0.9106
CYP450 2C19 substrateNon-inhibitor0.72
CYP450 3A4 substrateNon-inhibitor0.9173
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8638
Ames testAMES toxic0.9107
CarcinogenicityCarcinogens 0.6822
BiodegradationReady biodegradable0.9479
Rat acute toxicity2.9173 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.512
hERG inhibition (predictor II)Non-inhibitor0.9382
Pharmacoeconomics
Manufacturers
  • Novadel pharma inc
  • Pohl boskamp
  • Graceway pharmaceuticals llc
  • Key pharmaceuticals inc sub schering plough corp
  • Hercon laboratories corp
  • Kremers urban co
  • Mylan technologies inc
  • Novartis pharmaceuticals corp
  • G pohl boskamp gmbh and co
  • Sanofi aventis us llc
  • Abraxis pharmaceutical products
  • Hospira inc
  • International medication systems ltd
  • Luitpold pharmaceuticals inc
  • Smith and nephew solopak div smith and nephew
  • Baxter healthcare corp
  • Rorer pharmaceutical corp sub rorer group
  • Parke davis div warner lambert co
  • E fougera div altana inc
  • Pfizer pharmaceuticals ltd
Packagers
Dosage forms
FormRouteStrength
Aerosol, meteredsublingual400 ug
Capsuleoral2.5 mg
Capsuleoral6.5 mg
Capsuleoral9 mg
Film, extended releasetransdermal20.8 mg
Film, extended releasetransdermal37.4 mg
Injection, solutionintravenous5 mg/mL
Ointmentrectal4 mg/g
Ointmenttopical20 mg/g
Patchtransdermal.1 mg/h
Patchtransdermal.2 mg/h
Patchtransdermal.4 mg/h
Patchtransdermal.6 mg/h
Patchtransdermal10 mg/d
Patchtransdermal120 mg
Patchtransdermal15 mg/d
Patchtransdermal160 mg
Patchtransdermal18 mg
Patchtransdermal2.5 mg/d
Patchtransdermal20 mg
Patchtransdermal36 mg
Patchtransdermal40 mg
Patchtransdermal5 mg/d
Patchtransdermal54 mg
Patchtransdermal60 mg
Patchtransdermal80 mg
Patchtransdermal9 mg
Sprayoral400 ug
Spray, meteredoral400 ug
Tabletoral.3 mg
Tabletoral.4 mg
Tabletsublingual.3 mg
Tabletsublingual.4 mg
Tabletsublingual.6 mg
Tablet, orally disintegratingsublingual.3 mg
Tablet, orally disintegratingsublingual.4 mg
Tablet, orally disintegratingsublingual.6 mg
Prices
Unit descriptionCostUnit
Nitrolingual 0.4 mg/spray Solution 12 gm Bottle242.83USD bottle
Nitrolingual 0.4 mg/spray Solution 4.9 gm Bottle141.43USD bottle
Nitro-Dur 30 0.6 mg/hr Patches Box130.86USD box
Nitro-Dur 30 0.8 mg/hr Patches Box130.86USD box
Nitro-Dur 30 0.3 mg/hr Patches Box120.68USD box
Nitro-Dur 30 0.4 mg/hr Patches Box117.1USD box
Minitran 30 0.6 mg/hr Patches Box114.01USD box
Nitro-Dur 30 0.1 mg/hr Patches Box106.09USD box
Nitro-Dur 30 0.2 mg/hr Patches Box105.6USD box
Minitran 30 0.4 mg/hr Patches Box105.18USD box
Minitran 30 0.2 mg/hr Patches Box93.86USD box
Minitran 30 0.1 mg/hr Patches Box92.36USD box
Nitroglycerin 30 0.6 mg/hr Patches Box63.55USD box
Nitroglycerin 5 mg/ml kit62.38USD kit
Nitroglycerin 30 0.4 mg/hr Patches Box57.62USD box
Nitroglycerin 30 0.2 mg/hr Patches Box50.44USD box
Nitrostat 100 0.4 mg Sublingual Tabs Bottle29.88USD bottle
Nitromist 400 mcg spray28.5USD g
Nitrostat 100 0.3 mg Sublingual Tabs Bottle27.75USD bottle
Nitrostat 100 0.6 mg Sublingual Tabs Bottle24.99USD bottle
Nitroglycerin 100 0.6 mg Sublingual Tabs Bottle23.99USD bottle
Nitroglycerin 100 0.3 mg Sublingual Tabs Bottle22.99USD bottle
Nitrostat 25 0.4 mg Sublingual Tabs Bottle19.31USD bottle
Nitroglycerin 25 0.4 mg Sublingual Tabs Bottle9.5USD bottle
Nitro-dur 0.6 mg/hr patch4.19USD patch
Nitro-dur 0.8 mg/hr patch4.19USD patch
Nitro-dur 0.3 mg/hr patch3.87USD patch
Nitro-dur 0.4 mg/hr patch3.87USD patch
Minitran 0.6 mg/hr patch3.51USD patch
Nitro-dur 0.2 mg/hr patch3.45USD patch
Nitro-dur 0.1 mg/hr patch3.4USD patch
Minitran 0.4 mg/hr patch3.24USD patch
Minitran 0.2 mg/hr patch2.89USD patch
Minitran 0.1 mg/hr patch2.84USD patch
Nitroglycerin CR 6.5 mg capsule1.66USD capsule
Nitroglycerin 0.1 mg/hr Patches1.64USD patch
Nitroglycerin CR 9 mg capsule1.27USD capsule
Nitro-Dur 0.8 0.8 mg/hr Patch1.16USD patch
Nitroglycerin er 9 mg capsule1.0USD capsule
Transderm-Nitro 0.4 0.4 mg/hr Patch0.81USD patch
Transderm-Nitro 0.6 0.6 mg/hr Patch0.81USD patch
Minitran 0.4 0.4 mg/hr Patch0.74USD patch
Minitran 0.6 0.6 mg/hr Patch0.74USD patch
Nitroglycerin er 6.5 mg capsule0.72USD capsule
Transderm-Nitro 0.2 0.2 mg/hr Patch0.71USD patch
Nitro-Dur 0.4 0.4 mg/hr Patch0.67USD patch
Nitro-Dur 0.6 0.6 mg/hr Patch0.67USD patch
Trinipatch 0.4 0.4 mg/hr Patch0.67USD patch
Trinipatch 0.6 0.6 mg/hr Patch0.67USD patch
Minitran 0.2 0.2 mg/hr Patch0.66USD patch
Nitrol 2 % Ointment0.64USD g
Nitro-Dur 0.2 0.2 mg/hr Patch0.59USD patch
Trinipatch 0.2 0.2 mg/hr Patch0.59USD patch
Nitroglycerin 9 mg capsule sa0.53USD capsule
Nitro-bid 2% ointment0.48USD g
Nitroglycerin CR 2.5 mg capsule0.47USD capsule
Nitro-time er 9 mg capsule0.37USD capsule
Nitroglycerin 0.4 mg tablet sl0.36USD tablet
Nitrostat 0.4 mg tablet sl0.35USD tablet
Nitro-time er 6.5 mg capsule0.33USD capsule
Nitro-time er 2.5 mg capsule0.29USD capsule
Nitroglycerin er 2.5 mg capsule0.28USD capsule
Nitroglycerin 6.5 mg capsule sa0.22USD capsule
Nitroquick 0.3 mg tablet sl0.19USD tablet
Nitroglycerin 2.5 mg capsule sa0.18USD capsule
Nitroglycerin 2% ointment0.17USD g
Nitrostat 0.6 mg tablet sl0.16USD tablet
Nitroglycerin 0.3 mg tablet sl0.14USD tablet
Nitroglycerin 0.6 mg tablet sl0.14USD tablet
Nitrostat 0.3 mg Sublingual Tablet0.13USD tablet
Nitrostat 0.6 mg Sublingual Tablet0.13USD tablet
Nitrolingual Pumpspray 0.4 mg/dose Metered Dose Spray0.08USD dose
Nitroquick 0.4 mg tablet sl0.08USD tablet
Nitroquick 0.6 mg tablet sl0.08USD tablet
Nitrostat 0.3 mg tablet sl0.07USD tablet
Mylan-Nitro 0.4 mg/dose Metered Dose Spray0.04USD dose
Ntg 25 mg/250 ml in d5w0.04USD ml
Rho-Nitro Pumpspray 0.4 mg/dose Metered Dose Spray0.04USD dose
Ntg 50 mg/500 ml in d5w0.02USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
CountryPatent NumberApprovedExpires (estimated)
United States51869381993-02-162010-02-16
United States65004561998-09-162018-09-16
Properties
StateLiquid
Experimental Properties
PropertyValueSource
melting point13.5 °CPhysProp
boiling point250 °CPhysProp
water solubility1380 mg/L (at 20 °C)SEIDELL,A (1941)
logP1.62HANSCH,C ET AL. (1995)
logS-2.22ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility0.204 mg/mLALOGPS
logP1.25ALOGPS
logP0.94ChemAxon
logS-3ALOGPS
pKa (Strongest Basic)-5.6ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count9ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area165.15 Å2ChemAxon
Rotatable Bond Count8ChemAxon
Refractivity40.6 m3·mol-1ChemAxon
Polarizability15.56 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (7.71 KB)
SpectraNot Available
References
Synthesis Reference

Izhak Blank, “Nitroglycerin preparations.” U.S. Patent US4482534, issued December, 1979.

US4482534
General ReferenceNot Available
External Links
ATC CodesC01DA02C05AE01
AHFS Codes
  • 24:12.08
  • 92:02.00*
PDB EntriesNot Available
FDA labelDownload (801 KB)
MSDSNot Available
Interactions
Drug Interactions
Drug
AlteplaseIV nitroglycerin may decrease the effect of alteplase.
AvanafilAdditive vasodilation. Concomitant therapy is contraindicated.
Azilsartan medoxomilPharmacodynamic synergist- increases effects.
DihydroergotaminePossible antagonism of action
ErgonovinePossible antagonism of action
ErgotaminePossible antagonism of action
MethylergometrinePossible antagonism of action
MethysergidePossible antagonism of action
SildenafilPossible significant hypotension with this combination
TadalafilThe vasodilatory effects of Nitroglycerin may be increased by Tadalafil. Severe hypotension may occur. Concomitant therapy is contraindicated.
TreprostinilAdditive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
UdenafilThe vasodilatory effects of Nitroglycerin may be increased by Udenafil. Severe hypotension may occur. Concomitant therapy is contraindicated.
VardenafilThe vasodilatory effects of Nitroglycerin may be increased by Vardenafil. Severe hypotension may occur. Concomitant therapy is contraindicated.
Food Interactions
  • Avoid alcohol.
  • Dissolve under the tongue.
  • Take on empty stomach: 1 hour before or 2 hours after meals.

Targets

1. Atrial natriuretic peptide receptor 1

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: agonist

Components

Name UniProt ID Details
Atrial natriuretic peptide receptor 1 P16066 Details

References:

  1. Madhani M, Scotland RS, MacAllister RJ, Hobbs AJ: Vascular natriuretic peptide receptor-linked particulate guanylate cyclases are modulated by nitric oxide-cyclic GMP signalling. Br J Pharmacol. 2003 Aug;139(7):1289-96. Pubmed
  2. Bauersachs J: Aminoethyl nitrate—the novel super nitrate? Br J Pharmacol. 2009 Sep;158(2):507-9. Pubmed

Enzymes

1. Aldehyde dehydrogenase, mitochondrial

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Aldehyde dehydrogenase, mitochondrial P05091 Details

References:

  1. Badejo AM Jr, Hodnette C, Dhaliwal JS, Casey DB, Pankey E, Murthy SN, Nossaman BD, Hyman AL, Kadowitz PJ: Mitochondrial aldehyde dehydrogenase mediates vasodilator responses of glyceryl trinitrate and sodium nitrite in the pulmonary vascular bed of the rat. Am J Physiol Heart Circ Physiol. 2010 Sep;299(3):H819-26. Epub 2010 Jun 11. Pubmed

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Drug created on June 13, 2005 07:24 / Updated on January 07, 2014 11:25