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Identification
NameNitroglycerin
Accession NumberDB00727  (APRD00153)
TypeSmall Molecule
GroupsApproved, Investigational
Description

A volatile vasodilator which relieves angina pectoris by stimulating guanylate cyclase and lowering cytosolic calcium. [PubChem]

Structure
Thumb
Synonyms
1,2,3-Propanetrioltrinitrate
1,2,3-Propanetriyl nitrate
Glycerin trinitrate
Glycerol trinitrate
Glycerol, nitric acid triester
Glyceroli trinitratis
Glyceroltrinitrat
Glyceryl trinitrate
Minitran
Natispray
NG
Nitro-dur
Nitroglicerina
Nitroglycerin
Nitroglycerine
Nitroglycerol
Nitrolingual
Nitromed
Nitromist
Nitrostat
Propane-1,2,3-triyl trinitrate
Rectogesic
Transderm nitro
Trinitrine
Trinitroglycerin
Trinitroglycerol
External Identifiers
  • DR 66
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Minitranpatch36 mgtransdermalValeant Canada Lp Valeant Canada S.E.C.1995-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Minitranpatch54 mgtransdermalValeant Canada Lp Valeant Canada S.E.C.1995-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Minitranpatch18 mgtransdermalValeant Canada Lp Valeant Canada S.E.C.1995-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Minitran - Patch Trd 72mg/26.6 Sq Cmpatch72 mgtransdermalGraceway PharmaceuticalsNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mylan-nitro Patch 0.2patch (extended release)20.7 mgtransdermalMylan Pharmaceuticals Ulc2013-06-04Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mylan-nitro Patch 0.4patch (extended release)41.4 mgtransdermalMylan Pharmaceuticals Ulc2013-06-04Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mylan-nitro Patch 0.6patch (extended release)62.2 mgtransdermalMylan Pharmaceuticals Ulc2013-06-04Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mylan-nitro Patch 0.8patch (extended release)82.9 mgtransdermalMylan Pharmaceuticals Ulc2013-06-04Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mylan-nitro Sublingual Spraymetered-dose aerosol0.4 mgsublingualMylan Pharmaceuticals Ulc2001-08-23Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nitro-durpatch80 mg/1transdermalMerck Sharp & Dohme Corp.1995-04-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitro-durpatch60 mg/1transdermalMerck Sharp & Dohme Corp.1995-04-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitro-durpatch40 mg/1transdermalMerck Sharp & Dohme Corp.1995-04-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitro-durpatch20 mg/1transdermalMerck Sharp & Dohme Corp.1995-04-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitro-durpatch160 mg/1transdermalMerck Sharp & Dohme Corp.1995-04-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitro-durpatch120 mg/1transdermalMerck Sharp & Dohme Corp.1995-04-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitro-dur 0.2patch (extended release)40 mgtransdermalMerck Canada Inc1991-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nitro-dur 0.3 - 60mg/15 Sq Cm, 0.3mg/hrpatch (extended release)60 mgtransdermalKey Pharmaceuticals, Division Of Schering Plough Canada Inc.1996-09-052004-07-20Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nitro-dur 0.4patch (extended release)80 mgtransdermalMerck Canada Inc1991-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nitro-dur 0.6patch (extended release)120 mgtransdermalMerck Canada Inc1991-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nitro-dur 0.8patch (extended release)160 mgtransdermalMerck Canada Inc1993-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nitro-timecapsule9 mg/1oralMajor Pharmaceuticals2004-01-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitro-timecapsule2.5 mg/1oralCarilion Materials Management2004-01-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitro-timecapsule6.5 mg/1oralMajor Pharmaceuticals2004-01-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitro-timecapsule9 mg/1oralCarilion Materials Management2004-01-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitro-timecapsule9 mg/1oralTIME CAP LABORATORIES, INC2014-06-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitro-timecapsule2.5 mg/1oralMajor Pharmaceuticals2004-01-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitro-timecapsule6.5 mg/1oralTIME CAP LABORATORIES, INC2014-06-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitro-timecapsule2.5 mg/1oralTIME CAP LABORATORIES, INC2014-06-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitro-timecapsule6.5 mg/1oralCarilion Materials Management2004-01-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitrogard-SR Tab 1mgtablet (extended-release)1 mgbuccalAstra Pharma Inc.1987-12-311996-11-13Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nitroglycerintablet, orally disintegrating.4 mg/1sublingualPhysicians Total Care, Inc.2009-06-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerintablet, orally disintegrating.3 mg/1sublingualGreenstone LLC2003-04-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerintablet, orally disintegrating.4 mg/1sublingualGreenstone LLC2003-04-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerintablet, orally disintegrating.6 mg/1sublingualGreenstone LLC2003-04-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerintablet.4 mg/1oralRebel Distributors Corp2005-03-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerintablet.4 mg/1oralPreferred Pharmaceuticals, Inc2005-03-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerininjection, solution5 mg/mLintravenousGENERAL INJECTABLES AND VACCINES, INC.2010-06-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerinaerosol, metered400 ug/1sublingualRouses Point Pharm2012-10-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin ERcapsule6.5 mg/1oralAv Kare, Inc.2012-12-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin ERcapsule2.5 mg/1oralAv Kare, Inc.2012-12-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin In Dextroseinjection40 mg/100mLintravenousBaxter Healthcare Company1989-12-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin In Dextroseinjection20 mg/100mLintravenousBaxter Healthcare Company1989-12-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin In Dextroseinjection10 mg/100mLintravenousBaxter Healthcare Company1989-12-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin Inj 5mg/mlliquid5 mgintravenousDavid Bull Laboratories (Pty) Ltd.1988-12-312000-08-01Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nitroglycerin Injection USPsolution5 mgintravenousSandoz Canada Incorporated1993-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nitroglycerin Lingualspray, metered400 ug/1sublingualWilshire Pharmaceuticals, Inc.2011-02-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin Slocapscapsule6.5 mg/1oralRebel Distributors Corp1982-08-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin Slocapscapsule2.5 mg/1oralRebel Distributors Corp1982-08-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroject Inj 1mg/mlliquid1 mgintravenousOmega Laboratories Ltd1990-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nitroject Inj 5mg/mlliquid5 mgintravenousOmega Laboratories Ltd1988-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nitrol (nitroglycerin Ointment 2%, USP)ointment2 %topicalPaladin Labs Inc1985-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nitrolingualspray400 ug/1oralRebel Distributors Corp1985-10-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitrolingual Pumpsprayspray, metered400 ug/1oralArbor Pharmaceuticals, Inc.2000-02-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitrolingual Pumpspraymetered-dose pump0.4 mgsublingualSanofi Aventis Canada Inc1998-07-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nitrolingual Spray 0.4mg/eammetered-dose aerosol0.4 mgsublingualAventis Pharma Inc1986-12-312001-07-20Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nitromistaerosol, metered400 ug/1sublingualAkrimax Pharmaceuticals, LLC2010-05-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitromistaerosol, metered400 ug/1sublingualMist Pharmaceuticals, Llc2016-01-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitrong SR Srt 2.6mgtablet (extended-release)2.6 mgoralMetro Pharm Inc.1964-12-312005-09-15Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nitrostattablet.4 mg/1oralGeneral Injectables & Vaccines, Inc2010-03-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitrostattablet.3 mg/1sublingualParke Davis Div Of Pfizer Inc2000-05-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitrostattablet.4 mg/1sublingualPreferred Pharmaceuticals, Inc.2013-05-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitrostattablet.4 mg/1sublingualA S Medication Solutions Llc2000-05-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitrostattablet.3 mg/1oralPhysicians Total Care, Inc.1994-09-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitrostattablet.4 mg/1sublingualA S Medication Solutions Llc2000-05-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitrostattablet.4 mg/1oralPhysicians Total Care, Inc.1995-08-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitrostattablet.4 mg/1sublingualA S Medication Solutions Llc2000-05-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitrostattablet.4 mg/1sublingualA S Medication Solutions Llc2000-05-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitrostattablet.6 mg/1sublingualParke Davis Div Of Pfizer Inc2000-05-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitrostattablet.4 mg/1sublingualAidarex Pharmaceuticals LLC2000-05-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitrostattablet.4 mg/1sublingualREMEDYREPACK INC.2012-03-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitrostattablet.4 mg/1sublingualParke Davis Div Of Pfizer Inc2000-05-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitrostattablet.4 mg/1sublingualCardinal Health2000-05-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitrostattablet.4 mg/1sublingualREMEDYREPACK INC.2013-05-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitrostattablet.4 mg/1sublingualRebel Distributors Corp2000-05-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitrostat Slt 0.3mgtablet0.3 mgsublingualPfizer Canada Inc1972-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nitrostat Slt 0.6mgtablet0.6 mgsublingualPfizer Canada Inc1972-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Rectivointment4 mg/grectalPro Strakan, Inc.2011-06-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Rectivointment4 mg/grectalAptalis Pharma US, Inc.2011-06-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Rho-nitro Pumpspraymetered-dose pump0.4 mgsublingualSandoz Canada Incorporated2001-12-20Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Transderm-nitro 0.2patch (extended release)25 mgtransdermalNovartis Pharmaceuticals Canada Inc1989-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Transderm-nitro 0.4patch (extended release)50 mgtransdermalNovartis Pharmaceuticals Canada Inc1989-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Transderm-nitro 0.6patch (extended release)75 mgtransdermalNovartis Pharmaceuticals Canada Inc1994-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Transderm-nitro 0.8patch (extended release)100 mgtransdermalNovartis Pharmaceuticals Canada Inc1994-12-311999-08-04Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Tridil Injection 5mg/mlliquid5 mgintravenousDupont Pharma Inc.1993-12-312001-08-07Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Trinipatch 0.2patch22.4 mgtransdermalPaladin Labs Inc1999-04-01Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Trinipatch 0.4patch44.8 mgtransdermalPaladin Labs Inc1999-04-01Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Trinipatch 0.6patch67.2 mgtransdermalPaladin Labs Inc1999-04-01Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-nitroglycerinmetered-dose pump0.4 mgsublingualApotex Inc2013-09-23Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Minitranpatch36 mg/1transdermalMedicis Pharmaceutical Corp2012-02-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Minitranpatch5 mg/dtransdermalGraceway Pharmaceuticals, LLC2007-04-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Minitranpatch18 mg/1transdermalMedicis Pharmaceutical Corp2012-02-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Minitranpatch2.5 mg/dtransdermalGraceway Pharmaceuticals, LLC2007-04-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Minitranpatch9 mg/1transdermalMedicis Pharmaceutical Corp2012-02-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Minitranpatch15 mg/dtransdermalGraceway Pharmaceuticals, LLC2007-04-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Minitranpatch54 mg/1transdermalMedicis Pharmaceutical Corp2012-02-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Minitranpatch10 mg/dtransdermalGraceway Pharmaceuticals, LLC2009-08-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitro-bidointment20 mg/gtopicalE. FOUGERA & CO., A division of Nycomed US Inc.2009-08-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitro-bidointment20 mg/gtopicalSavage Laboratories a division of Fougera Pharmaceuticals Inc.2009-08-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerinfilm, extended release20.8 mg/1transdermalKremers Urban Pharmaceuticals Inc.2004-08-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerinpatch.6 mg/htransdermalMylan Pharmaceuticals Inc.1996-08-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerinpatch.4 mg/htransdermalMylan Pharmaceuticals Inc.1996-08-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerinpatch.2 mg/htransdermalMylan Pharmaceuticals Inc.1996-08-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerinpatch.1 mg/htransdermalMylan Pharmaceuticals Inc.1998-06-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerininjection, solution5 mg/mLintravenousAmerican Regent, Inc.2003-03-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerininjection, solution5 mg/mLintravenousCardinal Health2003-03-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerinfilm, extended release37.4 mg/1transdermalKremers Urban Pharmaceuticals Inc.2004-08-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin ERcapsule9 mg/1oralPd Rx Pharmaceuticals, Inc.2010-05-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin ERcapsule6.5 mg/1oralPd Rx Pharmaceuticals, Inc.2010-05-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin ERcapsule2.5 mg/1oralPd Rx Pharmaceuticals, Inc.2010-05-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin In Dextroseinjection, solution100 ug/mLintravenousHospira, Inc.1990-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin In Dextroseinjection, solution200 ug/mLintravenousHospira, Inc.1990-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin In Dextroseinjection, solution400 ug/mLintravenousHospira, Inc.1990-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin Lingualspray400 ug/1oralPerrigo New York Inc2013-09-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin Transdermal Delivery Systempatch2.5 mg/dtransdermalGraceway Pharmaceuticals, LLC2007-04-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin Transdermal Delivery Systempatch.4 mg/htransdermalAlvogen, Inc.2010-11-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin Transdermal Delivery Systempatch2.5 mg/dtransdermalPhysicians Total Care, Inc.2006-05-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin Transdermal Delivery Systempatch.2 mg/htransdermalAlvogen, Inc.2010-11-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin Transdermal Delivery Systempatch5 mg/dtransdermalPhysicians Total Care, Inc.2004-10-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin Transdermal Delivery Systempatch.1 mg/htransdermalAlvogen, Inc.2010-11-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin Transdermal Delivery Systempatch10 mg/dtransdermalPhysicians Total Care, Inc.2004-10-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin Transdermal Delivery Systempatch15 mg/dtransdermalGraceway Pharmaceuticals, LLC2007-04-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin Transdermal Delivery Systempatch10 mg/dtransdermalGraceway Pharmaceuticals, LLC2007-04-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin Transdermal Delivery Systempatch5 mg/dtransdermalGraceway Pharmaceuticals, LLC2007-04-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin Transdermal Delivery Systempatch.6 mg/htransdermalAlvogen, Inc.2010-11-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin Transdermal Systempatch.6 mg/htransdermalHarvard Drug Group, LLC1998-10-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin Transdermal Systempatch.6 mg/htransdermalHercon Laboratories Corporation1998-10-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin Transdermal Systempatch.4 mg/htransdermalHarvard Drug Group, LLC1998-10-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin Transdermal Systempatch.4 mg/htransdermalHercon Laboratories Corporation1998-10-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin Transdermal Systempatch.2 mg/htransdermalHarvard Drug Group, LLC1998-10-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin Transdermal Systempatch.2 mg/htransdermalHercon Laboratories Corporation1998-10-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nitroglycerin Transdermal Systempatch.2 mg/htransdermalCardinal Health1998-10-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Over the Counter ProductsNot Available
International Brands
NameCompany
DeponitUCB Pharma
DermatransBayer
Gen-NitroGenpharm ULC
GlytrinSanofi-Aventis
Glytrin SpraySanofi-Aventis
NatisprayTeofarma
NitrocapOrion
Nitroderm TTSNovartis
Nitrolingual Pump SprayArbor Pharmaceuticals
RectogesicProStrakan
StangylNot Available
Transderm-NitroNovartis
TridilNot Available
TrimonitSanofi-Aventis
TrinipatchPaladin
TriniplasNovartis
TrinispraySanofi Aventis
Trinitrin Simplex LaleufSanofi
TrinitronQuesada
TrinitrosanMerck
TrintekGoldshield
TrocerIncepta
Trocer SRIncepta
VasolatorSanwa Kagaku
VasovinTorrent
VenitrinMeda
VerniesParke Davis
WilllongWill-Pharma
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIG59M7S0WS3
CAS number55-63-0
WeightAverage: 227.0865
Monoisotopic: 227.002578773
Chemical FormulaC3H5N3O9
InChI KeyInChIKey=SNIOPGDIGTZGOP-UHFFFAOYSA-N
InChI
InChI=1S/C3H5N3O9/c7-4(8)13-1-3(15-6(11)12)2-14-5(9)10/h3H,1-2H2
IUPAC Name
1,3-bis(nitrooxy)propan-2-yl nitrate
SMILES
[O-][N+](=O)OCC(CO[N+]([O-])=O)O[N+]([O-])=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as nitrate esters. These are compounds containing a nitrate ester functional group, with the general structure RON+(=O)O, (R cannot be a hydrogen).
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassOrganic nitric acids and derivatives
Sub ClassNitrate esters
Direct ParentNitrate esters
Alternative Parents
Substituents
  • Alkyl nitrate
  • Organic nitrate
  • Nitrate ester
  • Organic nitro compound
  • Organic 1,3-dipolar compound
  • Allyl-type 1,3-dipolar organic compound
  • Hydrocarbon derivative
  • Organic salt
  • Organooxygen compound
  • Organic zwitterion
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Pharmacology
IndicationFor the prevention of angina
PharmacodynamicsNitroglycerin, an organic nitrate, is available in many forms as a vasodilator. Nitroglycerin is used in the treatement of angina pectoris and perioperative hypertension, to produce controlled hypotension during surgical procedures, to treat hypertensive emergencies, and to treat congestive heart failure associated with myocardial infarction.
Mechanism of actionSimilar to other nitrites and organic nitrates, nitroglycerin is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase. This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.
AbsorptionNot Available
Volume of distribution
  • 3 L/kg
Protein bindingNot Available
Metabolism

Hepatic, cytochrome P450 (P450) is a key enzyme of organic nitrate biotransformation

Route of eliminationNot Available
Half life3 minutes
Clearance
  • 1 L/kg/min
ToxicityIncreased intracranial pressure, with any or all of persistent throbbing headache, confusion, and moderate fever; Vertigo; Palpitations; Visual disturbances; Nausea and vomiting (possibly with colic and even bloody diarrhea); Syncope (especially in the upright posture); Air hunger and dyspnea, later followed by reduced ventilatory effort; Diaphoresis, with the skin either flushed or cold and clammy; Heart block and bradycardia; Paralysis; Coma; Seizures; Death.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.7613
Blood Brain Barrier+0.9113
Caco-2 permeable-0.5775
P-glycoprotein substrateNon-substrate0.8322
P-glycoprotein inhibitor INon-inhibitor0.671
P-glycoprotein inhibitor IINon-inhibitor0.9005
Renal organic cation transporterNon-inhibitor0.8325
CYP450 2C9 substrateNon-substrate0.8982
CYP450 2D6 substrateNon-substrate0.9022
CYP450 3A4 substrateNon-substrate0.5255
CYP450 1A2 substrateNon-inhibitor0.8022
CYP450 2C9 inhibitorNon-inhibitor0.7789
CYP450 2D6 inhibitorNon-inhibitor0.9106
CYP450 2C19 inhibitorNon-inhibitor0.72
CYP450 3A4 inhibitorNon-inhibitor0.9173
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8638
Ames testAMES toxic0.9107
CarcinogenicityCarcinogens 0.6822
BiodegradationReady biodegradable0.9479
Rat acute toxicity2.9173 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.512
hERG inhibition (predictor II)Non-inhibitor0.9382
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Novadel pharma inc
  • Pohl boskamp
  • Graceway pharmaceuticals llc
  • Key pharmaceuticals inc sub schering plough corp
  • Hercon laboratories corp
  • Kremers urban co
  • Mylan technologies inc
  • Novartis pharmaceuticals corp
  • G pohl boskamp gmbh and co
  • Sanofi aventis us llc
  • Abraxis pharmaceutical products
  • Hospira inc
  • International medication systems ltd
  • Luitpold pharmaceuticals inc
  • Smith and nephew solopak div smith and nephew
  • Baxter healthcare corp
  • Rorer pharmaceutical corp sub rorer group
  • Parke davis div warner lambert co
  • E fougera div altana inc
  • Pfizer pharmaceuticals ltd
Packagers
Dosage forms
FormRouteStrength
Patchtransdermal10 mg/d
Patchtransdermal15 mg/d
Patchtransdermal18 mg
Patchtransdermal18 mg/1
Patchtransdermal2.5 mg/d
Patchtransdermal36 mg
Patchtransdermal36 mg/1
Patchtransdermal5 mg/d
Patchtransdermal54 mg/1
Patchtransdermal54 mg
Patchtransdermal9 mg/1
Patchtransdermal72 mg
Patch (extended release)transdermal20.7 mg
Patch (extended release)transdermal41.4 mg
Patch (extended release)transdermal62.2 mg
Patch (extended release)transdermal82.9 mg
Metered-dose aerosolsublingual0.4 mg
Ointmenttopical20 mg/g
Patchtransdermal120 mg/1
Patchtransdermal160 mg/1
Patchtransdermal20 mg/1
Patchtransdermal40 mg/1
Patchtransdermal60 mg/1
Patchtransdermal80 mg/1
Patch (extended release)transdermal40 mg
Patch (extended release)transdermal60 mg
Patch (extended release)transdermal80 mg
Patch (extended release)transdermal120 mg
Patch (extended release)transdermal160 mg
Capsuleoral2.5 mg/1
Capsuleoral6.5 mg/1
Capsuleoral9 mg/1
Tablet (extended-release)buccal1 mg
Film, extended releasetransdermal20.8 mg/1
Film, extended releasetransdermal37.4 mg/1
Injection, solutionintravenous5 mg/mL
Patchtransdermal.1 mg/h
Patchtransdermal.2 mg/h
Patchtransdermal.4 mg/h
Patchtransdermal.6 mg/h
Tabletoral.4 mg/1
Tablet, orally disintegratingsublingual.3 mg/1
Tablet, orally disintegratingsublingual.4 mg/1
Tablet, orally disintegratingsublingual.6 mg/1
Injectionintravenous10 mg/100mL
Injectionintravenous20 mg/100mL
Injectionintravenous40 mg/100mL
Injection, solutionintravenous100 ug/mL
Injection, solutionintravenous200 ug/mL
Injection, solutionintravenous400 ug/mL
Solutionintravenous5 mg
Spray, meteredsublingual400 ug/1
Liquidintravenous1 mg
Liquidintravenous5 mg
Ointmenttopical2 %
Sprayoral400 ug/1
Metered-dose pumpsublingual0.4 mg
Spray, meteredoral400 ug/1
Aerosol, meteredsublingual400 ug/1
Tablet (extended-release)oral2.6 mg
Tabletoral.3 mg/1
Tabletsublingual.3 mg/1
Tabletsublingual.4 mg/1
Tabletsublingual.6 mg/1
Tabletsublingual0.3 mg
Tabletsublingual0.6 mg
Ointmentrectal4 mg/g
Patch (extended release)transdermal25 mg
Patch (extended release)transdermal50 mg
Patch (extended release)transdermal75 mg
Patch (extended release)transdermal100 mg
Patchtransdermal22.4 mg
Patchtransdermal44.8 mg
Patchtransdermal67.2 mg
Prices
Unit descriptionCostUnit
Nitrolingual 0.4 mg/spray Solution 12 gm Bottle242.83USD bottle
Nitrolingual 0.4 mg/spray Solution 4.9 gm Bottle141.43USD bottle
Nitro-Dur 30 0.6 mg/hr Patches Box130.86USD box
Nitro-Dur 30 0.8 mg/hr Patches Box130.86USD box
Nitro-Dur 30 0.3 mg/hr Patches Box120.68USD box
Nitro-Dur 30 0.4 mg/hr Patches Box117.1USD box
Minitran 30 0.6 mg/hr Patches Box114.01USD box
Nitro-Dur 30 0.1 mg/hr Patches Box106.09USD box
Nitro-Dur 30 0.2 mg/hr Patches Box105.6USD box
Minitran 30 0.4 mg/hr Patches Box105.18USD box
Minitran 30 0.2 mg/hr Patches Box93.86USD box
Minitran 30 0.1 mg/hr Patches Box92.36USD box
Nitroglycerin 30 0.6 mg/hr Patches Box63.55USD box
Nitroglycerin 5 mg/ml kit62.38USD kit
Nitroglycerin 30 0.4 mg/hr Patches Box57.62USD box
Nitroglycerin 30 0.2 mg/hr Patches Box50.44USD box
Nitrostat 100 0.4 mg Sublingual Tabs Bottle29.88USD bottle
Nitromist 400 mcg spray28.5USD g
Nitrostat 100 0.3 mg Sublingual Tabs Bottle27.75USD bottle
Nitrostat 100 0.6 mg Sublingual Tabs Bottle24.99USD bottle
Nitroglycerin 100 0.6 mg Sublingual Tabs Bottle23.99USD bottle
Nitroglycerin 100 0.3 mg Sublingual Tabs Bottle22.99USD bottle
Nitrostat 25 0.4 mg Sublingual Tabs Bottle19.31USD bottle
Nitroglycerin 25 0.4 mg Sublingual Tabs Bottle9.5USD bottle
Nitro-dur 0.6 mg/hr patch4.19USD patch
Nitro-dur 0.8 mg/hr patch4.19USD patch
Nitro-dur 0.3 mg/hr patch3.87USD patch
Nitro-dur 0.4 mg/hr patch3.87USD patch
Minitran 0.6 mg/hr patch3.51USD patch
Nitro-dur 0.2 mg/hr patch3.45USD patch
Nitro-dur 0.1 mg/hr patch3.4USD patch
Minitran 0.4 mg/hr patch3.24USD patch
Minitran 0.2 mg/hr patch2.89USD patch
Minitran 0.1 mg/hr patch2.84USD patch
Nitroglycerin CR 6.5 mg capsule1.66USD capsule
Nitroglycerin 0.1 mg/hr Patches1.64USD patch
Nitroglycerin CR 9 mg capsule1.27USD capsule
Nitro-Dur 0.8 0.8 mg/hr Patch1.16USD patch
Nitroglycerin er 9 mg capsule1.0USD capsule
Transderm-Nitro 0.4 0.4 mg/hr Patch0.81USD patch
Transderm-Nitro 0.6 0.6 mg/hr Patch0.81USD patch
Minitran 0.4 0.4 mg/hr Patch0.74USD patch
Minitran 0.6 0.6 mg/hr Patch0.74USD patch
Nitroglycerin er 6.5 mg capsule0.72USD capsule
Transderm-Nitro 0.2 0.2 mg/hr Patch0.71USD patch
Nitro-Dur 0.4 0.4 mg/hr Patch0.67USD patch
Nitro-Dur 0.6 0.6 mg/hr Patch0.67USD patch
Trinipatch 0.4 0.4 mg/hr Patch0.67USD patch
Trinipatch 0.6 0.6 mg/hr Patch0.67USD patch
Minitran 0.2 0.2 mg/hr Patch0.66USD patch
Nitrol 2 % Ointment0.64USD g
Nitro-Dur 0.2 0.2 mg/hr Patch0.59USD patch
Trinipatch 0.2 0.2 mg/hr Patch0.59USD patch
Nitroglycerin 9 mg capsule sa0.53USD capsule
Nitro-bid 2% ointment0.48USD g
Nitroglycerin CR 2.5 mg capsule0.47USD capsule
Nitro-time er 9 mg capsule0.37USD capsule
Nitroglycerin 0.4 mg tablet sl0.36USD tablet
Nitrostat 0.4 mg tablet sl0.35USD tablet
Nitro-time er 6.5 mg capsule0.33USD capsule
Nitro-time er 2.5 mg capsule0.29USD capsule
Nitroglycerin er 2.5 mg capsule0.28USD capsule
Nitroglycerin 6.5 mg capsule sa0.22USD capsule
Nitroquick 0.3 mg tablet sl0.19USD tablet
Nitroglycerin 2.5 mg capsule sa0.18USD capsule
Nitroglycerin 2% ointment0.17USD g
Nitrostat 0.6 mg tablet sl0.16USD tablet
Nitroglycerin 0.3 mg tablet sl0.14USD tablet
Nitroglycerin 0.6 mg tablet sl0.14USD tablet
Nitrostat 0.3 mg Sublingual Tablet0.13USD tablet
Nitrostat 0.6 mg Sublingual Tablet0.13USD tablet
Nitrolingual Pumpspray 0.4 mg/dose Metered Dose Spray0.08USD dose
Nitroquick 0.4 mg tablet sl0.08USD tablet
Nitroquick 0.6 mg tablet sl0.08USD tablet
Nitrostat 0.3 mg tablet sl0.07USD tablet
Mylan-Nitro 0.4 mg/dose Metered Dose Spray0.04USD dose
Ntg 25 mg/250 ml in d5w0.04USD ml
Rho-Nitro Pumpspray 0.4 mg/dose Metered Dose Spray0.04USD dose
Ntg 50 mg/500 ml in d5w0.02USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
CountryPatent NumberApprovedExpires (estimated)
United States51869381993-02-162010-02-16
United States65004561998-09-162018-09-16
Properties
StateLiquid
Experimental Properties
PropertyValueSource
melting point13.5 °CPhysProp
boiling point250 °CPhysProp
water solubility1380 mg/L (at 20 °C)SEIDELL,A (1941)
logP1.62HANSCH,C ET AL. (1995)
logS-2.22ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility0.204 mg/mLALOGPS
logP1.25ALOGPS
logP0.94ChemAxon
logS-3ALOGPS
pKa (Strongest Basic)-5.6ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count9ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area165.15 Å2ChemAxon
Rotatable Bond Count8ChemAxon
Refractivity40.6 m3·mol-1ChemAxon
Polarizability15.56 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (7.71 KB)
SpectraNot Available
References
Synthesis Reference

Izhak Blank, “Nitroglycerin preparations.” U.S. Patent US4482534, issued December, 1979.

US4482534
General ReferencesNot Available
External Links
ATC CodesC01DA02C05AE01
AHFS Codes
  • 24:12.08
  • 92:02.00*
PDB EntriesNot Available
FDA labelDownload (801 KB)
MSDSNot Available
Interactions
Drug Interactions
Drug
AldesleukinThe risk or severity of adverse effects can be increased when Aldesleukin is combined with Nitroglycerin.
AlfuzosinAlfuzosin may increase the hypotensive activities of Nitroglycerin.
AlteplaseThe serum concentration of Alteplase can be decreased when it is combined with Nitroglycerin.
BromocriptineBromocriptine may decrease the vasodilatory activities of Nitroglycerin.
ButabarbitalButabarbital may increase the hypotensive activities of Nitroglycerin.
ButethalButethal may increase the hypotensive activities of Nitroglycerin.
CabergolineCabergoline may decrease the vasodilatory activities of Nitroglycerin.
DapoxetineDapoxetine may increase the orthostatic hypotensive activities of Nitroglycerin.
DapsoneThe risk or severity of adverse effects can be increased when Dapsone is combined with Nitroglycerin.
DihydroergotamineDihydroergotamine may decrease the vasodilatory activities of Nitroglycerin.
DuloxetineNitroglycerin may increase the orthostatic hypotensive activities of Duloxetine.
Ergoloid mesylateErgoloid mesylate may decrease the vasodilatory activities of Nitroglycerin.
ErgonovineErgonovine may decrease the vasodilatory activities of Nitroglycerin.
ErgotamineErgotamine may decrease the vasodilatory activities of Nitroglycerin.
EthanolEthanol may increase the vasodilatory activities of Nitroglycerin.
HeparinNitroglycerin may decrease the anticoagulant activities of Heparin.
HeptabarbitalHeptabarbital may increase the hypotensive activities of Nitroglycerin.
HexobarbitalHexobarbital may increase the hypotensive activities of Nitroglycerin.
LevodopaNitroglycerin may increase the orthostatic hypotensive activities of Levodopa.
MethohexitalMethohexital may increase the hypotensive activities of Nitroglycerin.
MolsidomineMolsidomine may increase the hypotensive activities of Nitroglycerin.
NicorandilNicorandil may increase the hypotensive activities of Nitroglycerin.
Nitric OxideThe risk or severity of adverse effects can be increased when Nitric Oxide is combined with Nitroglycerin.
PentobarbitalPentobarbital may increase the hypotensive activities of Nitroglycerin.
PrilocaineThe risk or severity of adverse effects can be increased when Nitroglycerin is combined with Prilocaine.
PrimidonePrimidone may increase the hypotensive activities of Nitroglycerin.
RiociguatNitroglycerin may increase the hypotensive activities of Riociguat.
RisperidoneNitroglycerin may increase the hypotensive activities of Risperidone.
RosiglitazoneThe risk or severity of adverse effects can be increased when Nitroglycerin is combined with Rosiglitazone.
SecobarbitalSecobarbital may increase the hypotensive activities of Nitroglycerin.
Sodium NitriteThe risk or severity of adverse effects can be increased when Nitroglycerin is combined with Sodium Nitrite.
TadalafilTadalafil may increase the vasodilatory activities of Nitroglycerin.
ValsartanThe risk or severity of adverse effects can be increased when Valsartan is combined with Nitroglycerin.
VardenafilVardenafil may increase the vasodilatory activities of Nitroglycerin.
Food Interactions
  • Avoid alcohol.
  • Dissolve under the tongue.
  • Take on empty stomach: 1 hour before or 2 hours after meals.

Targets

1. Atrial natriuretic peptide receptor 1

Kind: Protein

Organism: Human

Pharmacological action: yes

Actions: agonist

Components

Name UniProt ID Details
Atrial natriuretic peptide receptor 1 P16066 Details

References:

  1. Madhani M, Scotland RS, MacAllister RJ, Hobbs AJ: Vascular natriuretic peptide receptor-linked particulate guanylate cyclases are modulated by nitric oxide-cyclic GMP signalling. Br J Pharmacol. 2003 Aug;139(7):1289-96. Pubmed
  2. Bauersachs J: Aminoethyl nitrate—the novel super nitrate? Br J Pharmacol. 2009 Sep;158(2):507-9. Pubmed

Enzymes

1. Aldehyde dehydrogenase, mitochondrial

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Aldehyde dehydrogenase, mitochondrial P05091 Details

References:

  1. Badejo AM Jr, Hodnette C, Dhaliwal JS, Casey DB, Pankey E, Murthy SN, Nossaman BD, Hyman AL, Kadowitz PJ: Mitochondrial aldehyde dehydrogenase mediates vasodilator responses of glyceryl trinitrate and sodium nitrite in the pulmonary vascular bed of the rat. Am J Physiol Heart Circ Physiol. 2010 Sep;299(3):H819-26. Epub 2010 Jun 11. Pubmed

Comments
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Drug created on June 13, 2005 07:24 / Updated on January 07, 2014 11:25