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Identification
NameRisperidone
Accession NumberDB00734  (APRD00187)
TypeSmall Molecule
GroupsApproved, Investigational
Description

Risperidone, a benzisoxazole derivative, is an atypical antipsychotic drug with high affinity for 5-hydrotryptamine (5-HT) and dopamine D2 receptors. It is used primarily in the management of schizophrenia, inappropriate behavior in severe dementia and manic episodes associated with bipolar I disorder. Risperidone is effective for treating the positive and negative symptoms of schizophrenia owing to its affinity for its “loose” binding affinity for dopamine D2 receptors and additional 5-HT antagonism compared to first generation antipsychotics, which are strong, non-specific dopamine D2 receptor antagonists.

Structure
Thumb
Synonyms
Risperdal
risperdone
Risperidona
Risperidonum
Risperin
Rispolept
Rispolin
Sequinan
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Act Risperidonetablet3 mgoralActavis Pharma Company2006-07-05Not applicableCanada
Act Risperidonetablet2 mgoralActavis Pharma Company2006-07-05Not applicableCanada
Act Risperidonetablet1 mgoralActavis Pharma Company2006-07-05Not applicableCanada
Act Risperidonetablet0.5 mgoralActavis Pharma Company2006-07-05Not applicableCanada
Act Risperidonetablet0.25 mgoralActavis Pharma Company2006-07-05Not applicableCanada
Act Risperidonetablet4 mgoralActavis Pharma Company2006-07-05Not applicableCanada
Ag-risperidonetablet1.0 mgoralAngita Pharma Inc.Not applicableNot applicableCanada
Ag-risperidonetablet3.0 mgoralAngita Pharma Inc.Not applicableNot applicableCanada
Ag-risperidonetablet0.50 mgoralAngita Pharma Inc.Not applicableNot applicableCanada
Ag-risperidonetablet0.25 mgoralAngita Pharma Inc.Not applicableNot applicableCanada
Ag-risperidonetablet2.0 mgoralAngita Pharma Inc.Not applicableNot applicableCanada
Ag-risperidonetablet4.0 mgoralAngita Pharma Inc.Not applicableNot applicableCanada
Ava-risperidonetablet2.0 mgoralAvanstra Inc2011-08-182014-08-21Canada
Ava-risperidonetablet4.0 mgoralAvanstra Inc2011-08-182014-08-21Canada
Ava-risperidonetablet1.0 mgoralAvanstra Inc2011-08-182014-08-21Canada
Ava-risperidonetablet0.5 mgoralAvanstra Inc2011-08-182014-08-21Canada
Ava-risperidonetablet0.25 mgoralAvanstra Inc2011-08-182014-08-21Canada
Ava-risperidonesolution1 mgoralAvanstra Inc2011-10-112014-08-21Canada
Ava-risperidonetablet3.0 mgoralAvanstra Inc2011-08-182014-08-21Canada
Dom-risperidonetablet1.0 mgoralDominion Pharmacal2006-08-08Not applicableCanada
Dom-risperidonetablet0.5 mgoralDominion Pharmacal2006-08-08Not applicableCanada
Dom-risperidonetablet0.25 mgoralDominion Pharmacal2006-08-08Not applicableCanada
Dom-risperidonetablet4.0 mgoralDominion Pharmacal2006-08-08Not applicableCanada
Dom-risperidonetablet3.0 mgoralDominion Pharmacal2006-08-08Not applicableCanada
Dom-risperidonetablet2.0 mgoralDominion Pharmacal2006-08-08Not applicableCanada
Dom-risperidonesolution1 mgoralDominion PharmacalNot applicableNot applicableCanada
Dom-risperidone ODTtablet (orally disintegrating)2 mgoralDominion PharmacalNot applicableNot applicableCanada
Dom-risperidone ODTtablet (orally disintegrating)1 mgoralDominion PharmacalNot applicableNot applicableCanada
Dom-risperidone ODTtablet (orally disintegrating)0.5 mgoralDominion PharmacalNot applicableNot applicableCanada
Ipg-risperidonetablet1 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-risperidonetablet0.5 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-risperidonetablet4 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-risperidonetablet0.25 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-risperidonetablet3 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-risperidonetablet2 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Jamp-risperidonetablet4.0 mgoralJamp Pharma Corporation2010-12-23Not applicableCanada
Jamp-risperidonetablet3.0 mgoralJamp Pharma Corporation2010-12-23Not applicableCanada
Jamp-risperidonetablet2.0 mgoralJamp Pharma Corporation2010-12-23Not applicableCanada
Jamp-risperidonetablet1.0 mgoralJamp Pharma Corporation2010-12-23Not applicableCanada
Jamp-risperidonesolution1 mgoralJamp Pharma CorporationNot applicableNot applicableCanada
Jamp-risperidonetablet0.50 mgoralJamp Pharma Corporation2010-12-23Not applicableCanada
Jamp-risperidonetablet0.25 mgoralJamp Pharma Corporation2010-12-23Not applicableCanada
Mar-risperidonetablet0.25 mgoralMarcan Pharmaceuticals Inc2013-04-17Not applicableCanada
Mar-risperidonetablet4.0 mgoralMarcan Pharmaceuticals Inc2013-04-17Not applicableCanada
Mar-risperidonetablet3.0 mgoralMarcan Pharmaceuticals Inc2013-04-17Not applicableCanada
Mar-risperidonetablet2.0 mgoralMarcan Pharmaceuticals Inc2013-04-17Not applicableCanada
Mar-risperidonetablet1.0 mgoralMarcan Pharmaceuticals Inc2013-04-17Not applicableCanada
Mar-risperidonetablet0.50 mgoralMarcan Pharmaceuticals Inc2013-04-17Not applicableCanada
Mint-risperidontablet0.25 mgoralMint Pharmaceuticals Inc2011-01-05Not applicableCanada
Mint-risperidontablet1.0 mgoralMint Pharmaceuticals Inc2011-01-05Not applicableCanada
Mint-risperidontablet4.0 mgoralMint Pharmaceuticals Inc2011-01-05Not applicableCanada
Mint-risperidontablet3.0 mgoralMint Pharmaceuticals Inc2011-01-05Not applicableCanada
Mint-risperidontablet0.50 mgoralMint Pharmaceuticals Inc2011-01-05Not applicableCanada
Mint-risperidontablet2.0 mgoralMint Pharmaceuticals Inc2011-01-05Not applicableCanada
Mylan-risperidonetablet0.25 mgoralMylan Pharmaceuticals Ulc2006-07-05Not applicableCanada
Mylan-risperidonetablet4.0 mgoralMylan Pharmaceuticals Ulc2006-07-05Not applicableCanada
Mylan-risperidonetablet3.0 mgoralMylan Pharmaceuticals Ulc2006-07-05Not applicableCanada
Mylan-risperidonetablet2.0 mgoralMylan Pharmaceuticals Ulc2006-07-05Not applicableCanada
Mylan-risperidonetablet1.0 mgoralMylan Pharmaceuticals Ulc2006-07-05Not applicableCanada
Mylan-risperidonetablet0.50 mgoralMylan Pharmaceuticals Ulc2006-07-05Not applicableCanada
Mylan-risperidone ODTtablet (orally disintegrating)1 mgoralMylan Pharmaceuticals Ulc2013-10-24Not applicableCanada
Mylan-risperidone ODTtablet (orally disintegrating)3 mgoralMylan Pharmaceuticals Ulc2013-10-24Not applicableCanada
Mylan-risperidone ODTtablet (orally disintegrating)0.5 mgoralMylan Pharmaceuticals Ulc2013-10-24Not applicableCanada
Mylan-risperidone ODTtablet (orally disintegrating)2 mgoralMylan Pharmaceuticals Ulc2013-10-24Not applicableCanada
Mylan-risperidone ODTtablet (orally disintegrating)4 mgoralMylan Pharmaceuticals Ulc2013-10-24Not applicableCanada
Nu-risperidonetablet0.5 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-risperidonetablet4 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-risperidonetablet3 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-risperidonetablet2 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-risperidonetablet0.25 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-risperidonetablet1 mgoralNu Pharm IncNot applicableNot applicableCanada
PHL-risperidonetablet0.25 mgoralPharmel Inc2006-08-09Not applicableCanada
PHL-risperidonetablet4.0 mgoralPharmel Inc2006-08-09Not applicableCanada
PHL-risperidonetablet3.0 mgoralPharmel Inc2006-08-09Not applicableCanada
PHL-risperidonetablet2.0 mgoralPharmel Inc2006-08-09Not applicableCanada
PHL-risperidonetablet1.0 mgoralPharmel Inc2006-08-09Not applicableCanada
PHL-risperidonetablet0.5 mgoralPharmel Inc2006-08-09Not applicableCanada
PHL-risperidone ODTtablet (orally disintegrating)2 mgoralPharmel IncNot applicableNot applicableCanada
PHL-risperidone ODTtablet (orally disintegrating)1 mgoralPharmel IncNot applicableNot applicableCanada
PHL-risperidone ODTtablet (orally disintegrating)0.5 mgoralPharmel IncNot applicableNot applicableCanada
PMS-risperidonetablet0.5 mgoralPharmascience Inc2006-07-05Not applicableCanada
PMS-risperidonetablet2.0 mgoralPharmascience Inc2006-07-05Not applicableCanada
PMS-risperidonetablet0.25 mgoralPharmascience Inc2006-07-05Not applicableCanada
PMS-risperidonesolution1 mgoralPharmascience Inc2006-07-05Not applicableCanada
PMS-risperidonetablet4.0 mgoralPharmascience Inc2006-07-05Not applicableCanada
PMS-risperidonetablet1.0 mgoralPharmascience Inc2006-07-05Not applicableCanada
PMS-risperidonetablet3.0 mgoralPharmascience Inc2006-07-05Not applicableCanada
PMS-risperidone ODTtablet (orally disintegrating)0.5 mgoralPharmascience Inc2007-03-13Not applicableCanada
PMS-risperidone ODTtablet (orally disintegrating)2 mgoralPharmascience Inc2007-03-13Not applicableCanada
PMS-risperidone ODTtablet (orally disintegrating)4 mgoralPharmascience Inc2011-12-16Not applicableCanada
PMS-risperidone ODTtablet (orally disintegrating)3 mgoralPharmascience Inc2011-12-16Not applicableCanada
PMS-risperidone ODTtablet (orally disintegrating)1 mgoralPharmascience Inc2007-03-13Not applicableCanada
Pro-risperidonetablet1.0 mgoralPro Doc Limitee2008-07-09Not applicableCanada
Pro-risperidonetablet0.5 mgoralPro Doc Limitee2008-07-09Not applicableCanada
Pro-risperidonetablet0.25 mgoralPro Doc Limitee2008-07-09Not applicableCanada
Pro-risperidonetablet4.0 mgoralPro Doc Limitee2008-07-09Not applicableCanada
Pro-risperidonetablet3.0 mgoralPro Doc Limitee2008-07-09Not applicableCanada
Pro-risperidonetablet2.0 mgoralPro Doc Limitee2008-07-09Not applicableCanada
Q-risperidonetablet0.50 mgoralQd Pharmaceuticals UlcNot applicableNot applicableCanada
Q-risperidonetablet4.0 mgoralQd Pharmaceuticals UlcNot applicableNot applicableCanada
Q-risperidonetablet3.0 mgoralQd Pharmaceuticals UlcNot applicableNot applicableCanada
Q-risperidonetablet2.0 mgoralQd Pharmaceuticals UlcNot applicableNot applicableCanada
Q-risperidonetablet0.25 mgoralQd Pharmaceuticals UlcNot applicableNot applicableCanada
Q-risperidonetablet1.0 mgoralQd Pharmaceuticals UlcNot applicableNot applicableCanada
Ran-risperidonetablet2.0 mgoralRanbaxy Pharmaceuticals Canada Inc.2009-10-22Not applicableCanada
Ran-risperidonetablet4.0 mgoralRanbaxy Pharmaceuticals Canada Inc.2009-10-22Not applicableCanada
Ran-risperidonetablet0.5 mgoralRanbaxy Pharmaceuticals Canada Inc.2006-06-302012-06-13Canada
Ran-risperidonetablet1.0 mgoralRanbaxy Pharmaceuticals Canada Inc.2009-10-22Not applicableCanada
Ran-risperidonetablet0.25 mgoralRanbaxy Pharmaceuticals Canada Inc.2006-06-302012-06-13Canada
Ran-risperidonetablet0.5 mgoralRanbaxy Pharmaceuticals Canada Inc.2009-10-22Not applicableCanada
Ran-risperidonetablet4 mgoralRanbaxy Pharmaceuticals Canada Inc.2006-06-302012-06-13Canada
Ran-risperidonetablet0.25 mgoralRanbaxy Pharmaceuticals Canada Inc.2009-10-22Not applicableCanada
Ran-risperidonetablet3 mgoralRanbaxy Pharmaceuticals Canada Inc.2006-06-302012-06-13Canada
Ran-risperidonetablet2 mgoralRanbaxy Pharmaceuticals Canada Inc.2006-06-302012-06-13Canada
Ran-risperidonetablet3.0 mgoralRanbaxy Pharmaceuticals Canada Inc.2009-10-22Not applicableCanada
Ran-risperidonetablet1 mgoralRanbaxy Pharmaceuticals Canada Inc.2006-06-302012-06-13Canada
Ratio-risperidonetablet4.0 mgoralRatiopharm Inc Division Of Teva Canada Limited2006-07-052015-10-26Canada
Ratio-risperidonetablet3.0 mgoralRatiopharm Inc Division Of Teva Canada Limited2006-07-052015-10-26Canada
Ratio-risperidonetablet2.0 mgoralRatiopharm Inc Division Of Teva Canada Limited2006-07-052015-10-26Canada
Ratio-risperidonetablet1.0 mgoralRatiopharm Inc Division Of Teva Canada Limited2006-07-052015-10-26Canada
Ratio-risperidonetablet0.5 mgoralRatiopharm Inc Division Of Teva Canada Limited2006-07-052015-10-26Canada
Ratio-risperidonetablet0.25 mgoralRatiopharm Inc Division Of Teva Canada Limited2006-07-052015-10-26Canada
Risperdalsolution1 mg/mLoralJanssen Pharmaceuticals, Inc.1996-06-10Not applicableUs
Risperdaltablet.5 mg/1oralPd Rx Pharmaceuticals, Inc.1993-12-29Not applicableUs
Risperdaltablet1 mg/1oralRebel Distributors Corp1993-12-29Not applicableUs
Risperdaltablet1 mg/1oralPd Rx Pharmaceuticals, Inc.1993-12-29Not applicableUs
Risperdaltablet3 mg/1oralJanssen Pharmaceuticals, Inc.1993-12-29Not applicableUs
Risperdaltablet2 mg/1oralCardinal Health1993-12-29Not applicableUs
Risperdaltablet.5 mg/1oralJanssen Pharmaceuticals, Inc.1993-12-29Not applicableUs
Risperdaltablet4 mgoralJanssen Inc1993-12-31Not applicableCanada
Risperdaltablet1 mg/1oralCardinal Health1993-12-29Not applicableUs
Risperdaltablet.25 mg/1oralJanssen Pharmaceuticals, Inc.1993-12-29Not applicableUs
Risperdaltablet2 mg/1oralJanssen Pharmaceuticals, Inc.1993-12-29Not applicableUs
Risperdaltablet3 mgoralJanssen Inc1993-12-31Not applicableCanada
Risperdaltablet.5 mg/1oralREMEDYREPACK INC.2013-05-072016-04-05Us
Risperdaltablet1 mg/1oralJanssen Pharmaceuticals, Inc.1993-12-29Not applicableUs
Risperdaltablet1 mgoralJanssen Inc1993-12-31Not applicableCanada
Risperdaltablet2 mgoralJanssen Inc1993-12-31Not applicableCanada
Risperdaltablet5 mgoralJanssen Inc1999-05-282009-08-05Canada
Risperdaltablet.5 mg/1oralREMEDYREPACK INC.2013-05-062016-04-05Us
Risperdaltablet.5 mg/1oralCardinal Health1993-12-29Not applicableUs
Risperdaltablet4 mg/1oralJanssen Pharmaceuticals, Inc.1993-12-29Not applicableUs
Risperdaltablet0.5 mgoralJanssen Inc1999-09-17Not applicableCanada
Risperdaltablet2 mg/1oralPd Rx Pharmaceuticals, Inc.1993-12-29Not applicableUs
Risperdaltablet3 mg/1oralRebel Distributors Corp1993-12-29Not applicableUs
Risperdaltablet4 mg/1oralPd Rx Pharmaceuticals, Inc.1993-12-29Not applicableUs
Risperdaltablet0.25 mgoralJanssen Inc1999-09-17Not applicableCanada
Risperdaltablet3 mg/1oralCardinal Health1993-12-29Not applicableUs
Risperdal ConstakitJanssen Pharmaceuticals, Inc.2003-10-29Not applicableUs
Risperdal Constapowder for suspension, sustained-release; kit50 mgintramuscularJanssen Inc2004-09-08Not applicableCanada
Risperdal Constapowder for suspension, sustained-release; kit37.5 mgintramuscularJanssen Inc2004-09-08Not applicableCanada
Risperdal Constapowder for suspension, sustained-release; kit25 mgintramuscularJanssen Inc2004-09-08Not applicableCanada
Risperdal ConstakitJanssen Pharmaceuticals, Inc.2003-10-29Not applicableUs
Risperdal ConstakitJanssen Pharmaceuticals, Inc.2003-10-29Not applicableUs
Risperdal Constapowder for suspension, sustained-release; kit12.5 mgintramuscularJanssen Inc2007-10-24Not applicableCanada
Risperdal ConstakitJanssen Pharmaceuticals, Inc.2003-10-29Not applicableUs
Risperdal M-tabtablet, orally disintegrating2 mg/1oralJanssen Pharmaceuticals, Inc.2003-04-02Not applicableUs
Risperdal M-tabtablet (orally disintegrating)2 mgoralJanssen Inc2003-07-27Not applicableCanada
Risperdal M-tabtablet (orally disintegrating)1 mgoralJanssen Inc2003-07-27Not applicableCanada
Risperdal M-tabtablet, orally disintegrating.5 mg/1oralJanssen Pharmaceuticals, Inc.2003-04-02Not applicableUs
Risperdal M-tabtablet, orally disintegrating1 mg/1oralJanssen Pharmaceuticals, Inc.2003-04-02Not applicableUs
Risperdal M-tabtablet (orally disintegrating)4 mgoralJanssen Inc2005-06-20Not applicableCanada
Risperdal M-tabtablet, orally disintegrating4 mg/1oralJanssen Pharmaceuticals, Inc.2003-04-02Not applicableUs
Risperdal M-tabtablet (orally disintegrating)0.5 mgoralJanssen Inc2003-07-27Not applicableCanada
Risperdal M-tabtablet (orally disintegrating)3 mgoralJanssen Inc2005-06-20Not applicableCanada
Risperdal M-tabtablet, orally disintegrating3 mg/1oralJanssen Pharmaceuticals, Inc.2003-04-02Not applicableUs
Risperdal Oral Solutionsolution1 mgoralJanssen Inc1998-03-04Not applicableCanada
Risperidonetablet1 mg/1oralJanssen Pharmaceutical, Inc.1993-12-29Not applicableUs
Risperidonetablet3 mg/1oralJanssen Pharmaceutical, Inc.1993-12-29Not applicableUs
Risperidonetablet0.5 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Risperidonetablet2.0 mgoralMeliapharm Inc2009-02-262014-06-25Canada
Risperidonetablet4.0 mgoralSanis Health Inc2010-10-21Not applicableCanada
Risperidonetablet.5 mg/1oralJanssen Pharmaceutical, Inc.1993-12-29Not applicableUs
Risperidonetablet2 mg/1oralCardinal Health1993-12-29Not applicableUs
Risperidonetablet0.25 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Risperidonetablet1.0 mgoralMeliapharm Inc2009-02-262014-06-25Canada
Risperidonetablet3.0 mgoralSanis Health Inc2010-10-21Not applicableCanada
Risperidonetablet.25 mg/1oralJanssen Pharmaceutical, Inc.1993-12-29Not applicableUs
Risperidonetablet1 mg/1oralCardinal Health1993-12-29Not applicableUs
Risperidonetablet0.5 mgoralMeliapharm Inc2009-02-262014-06-25Canada
Risperidonetablet2.0 mgoralSanis Health Inc2010-10-21Not applicableCanada
Risperidonetablet.5 mg/1oralCardinal Health1993-12-29Not applicableUs
Risperidonetablet4.0 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Risperidonetablet0.25 mgoralMeliapharm Inc2009-02-262014-06-25Canada
Risperidonetablet1.0 mgoralSanis Health Inc2010-10-21Not applicableCanada
Risperidonetablet.5 mg/1oralREMEDYREPACK INC.2013-05-06Not applicableUs
Risperidonetablet.25 mg/1oralCardinal Health1993-12-29Not applicableUs
Risperidonetablet3.0 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Risperidonetablet1 mg/1oralA S Medication Solutions1993-12-29Not applicableUs
Risperidonetablet0.5 mgoralSanis Health Inc2010-10-21Not applicableCanada
Risperidonesolution1 mg/mLoralJanssen Pharmaceutical, Inc.1996-06-10Not applicableUs
Risperidonetablet2.0 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Risperidonetablet4.0 mgoralMeliapharm Inc2009-02-262014-06-25Canada
Risperidonetablet2 mg/1oralJanssen Pharmaceutical, Inc.1993-12-29Not applicableUs
Risperidonetablet0.25 mgoralSanis Health Inc2010-10-21Not applicableCanada
Risperidonetablet4 mg/1oralJanssen Pharmaceutical, Inc.1993-12-29Not applicableUs
Risperidonetablet1.0 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Risperidonetablet3.0 mgoralMeliapharm Inc2009-02-262014-06-25Canada
Risperidone - 0.25tablet0.25 mgoralPro Doc Limitee2007-10-292008-07-25Canada
Risperidone - 0.5tablet0.50 mgoralPro Doc Limitee2007-10-292008-07-25Canada
Risperidone - 1tablet1.0 mgoralPro Doc Limitee2007-10-292008-07-25Canada
Risperidone - 2tablet2.0 mgoralPro Doc Limitee2007-10-292008-07-25Canada
Risperidone - 3tablet3.0 mgoralPro Doc Limitee2007-10-292008-07-25Canada
Risperidone - 4tablet4.0 mgoralPro Doc Limitee2007-10-292008-07-25Canada
Risperidone M-tabtablet, orally disintegrating3 mg/1oralJanssen Pharmaceutical, Inc.2003-04-02Not applicableUs
Risperidone M-tabtablet, orally disintegrating2 mg/1oralJanssen Pharmaceutical, Inc.2003-04-02Not applicableUs
Risperidone M-tabtablet, orally disintegrating1 mg/1oralJanssen Pharmaceutical, Inc.2003-04-02Not applicableUs
Risperidone M-tabtablet, orally disintegrating.5 mg/1oralJanssen Pharmaceutical, Inc.2003-04-02Not applicableUs
Risperidone M-tabtablet, orally disintegrating4 mg/1oralJanssen Pharmaceutical, Inc.2003-04-02Not applicableUs
Risperidone Tabletstablet4.0 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Risperidone Tabletstablet3.0 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Risperidone Tabletstablet2.0 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Risperidone Tabletstablet1.0 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Risperidone Tabletstablet0.5 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Risperidone Tabletstablet0.25 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Riva-risperidonetablet4.0 mgoralLaboratoire Riva Inc2006-07-31Not applicableCanada
Riva-risperidonetablet3.0 mgoralLaboratoire Riva Inc2006-07-31Not applicableCanada
Riva-risperidonetablet2.0 mgoralLaboratoire Riva Inc2006-07-31Not applicableCanada
Riva-risperidonetablet1.0 mgoralLaboratoire Riva Inc2006-07-31Not applicableCanada
Riva-risperidonetablet0.50 mgoralLaboratoire Riva Inc2006-07-31Not applicableCanada
Riva-risperidonetablet0.25 mgoralLaboratoire Riva Inc2006-07-31Not applicableCanada
Sandoz Risperidonetablet3.0 mgoralSandoz Canada Incorporated2006-07-05Not applicableCanada
Sandoz Risperidonetablet2.0 mgoralSandoz Canada Incorporated2006-07-05Not applicableCanada
Sandoz Risperidonetablet0.25 mgoralSandoz Canada Incorporated2007-03-082008-08-07Canada
Sandoz Risperidonetablet1.0 mgoralSandoz Canada Incorporated2006-07-05Not applicableCanada
Sandoz Risperidonetablet0.25 mgoralSandoz Canada Incorporated2006-07-052008-08-07Canada
Sandoz Risperidonetablet0.5 mgoralSandoz Canada Incorporated2006-07-052008-08-07Canada
Sandoz Risperidonetablet0.5 mgoralSandoz Canada Incorporated2007-12-21Not applicableCanada
Sandoz Risperidonetablet0.25 mgoralSandoz Canada Incorporated2007-12-21Not applicableCanada
Sandoz Risperidonetablet4.0 mgoralSandoz Canada Incorporated2006-07-05Not applicableCanada
Teva-risperidonetablet1.0 mgoralTeva Canada Limited2006-07-05Not applicableCanada
Teva-risperidonetablet3.0 mgoralTeva Canada Limited2006-07-05Not applicableCanada
Teva-risperidonetablet0.25 mgoralTeva Canada Limited2006-07-05Not applicableCanada
Teva-risperidonetablet0.5 mgoralTeva Canada Limited2006-07-05Not applicableCanada
Teva-risperidonetablet2.0 mgoralTeva Canada Limited2006-07-05Not applicableCanada
Teva-risperidonetablet4.0 mgoralTeva Canada Limited2006-07-05Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-risperidonetablet1.0 mgoralApotex Inc2006-07-05Not applicableCanada
Apo-risperidonetablet0.50 mgoralApotex Inc2006-07-05Not applicableCanada
Apo-risperidonetablet0.25 mgoralApotex Inc2006-07-05Not applicableCanada
Apo-risperidonesolution1 mgoralApotex Inc2006-07-05Not applicableCanada
Apo-risperidonetablet4.0 mgoralApotex Inc2006-07-05Not applicableCanada
Apo-risperidonetablet3.0 mgoralApotex Inc2006-07-05Not applicableCanada
Apo-risperidonetablet2.0 mgoralApotex Inc2006-07-05Not applicableCanada
Risperidonetablet4 mg/1oralContract Pharmacy Services Pa2010-08-25Not applicableUs
Risperidonetablet, orally disintegrating2 mg/1oralZydus Pharmaceuticals (USA) Inc.2010-06-29Not applicableUs
Risperidonetablet, film coated3 mg/1oralMc Kesson Contract Packaging2012-01-03Not applicableUs
Risperidonetablet, film coated1 mg/1oralCardinal Health2008-11-13Not applicableUs
Risperidonetablet2 mg/1oralCaraco Pharmaceutical Laboratories, Ltd.2014-03-10Not applicableUs
Risperidonetablet, film coated3 mg/1oralClinical Solutions Wholesale2008-12-29Not applicableUs
Risperidonetablet, orally disintegrating2 mg/1oralJubilant Cadista Pharmaceuticals Inc.2010-12-01Not applicableUs
Risperidonetablet, film coated.25 mg/1oralQualitest Pharmaceuticals2008-12-29Not applicableUs
Risperidonetablet, film coated2 mg/1oralGen Source Rx2009-10-252016-03-29Us
Risperidonetablet, film coated4 mg/1oralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
Risperidonetablet, orally disintegrating1 mg/1oralDr. Reddy's Laboratories Limited2009-10-06Not applicableUs
Risperidonetablet.5 mg/1oralRebel Distributors Corp2009-07-01Not applicableUs
Risperidonetablet, orally disintegrating2 mg/1oralSandoz Inc2009-12-22Not applicableUs
Risperidonetablet, orally disintegrating1 mg/1oralSun Pharmaceutical Industries Limited2013-04-13Not applicableUs
Risperidonetablet, film coated2 mg/1oralbryant ranch prepack2008-12-29Not applicableUs
Risperidonetablet2 mg/1oralTYA Pharmaceuticals2012-04-25Not applicableUs
Risperidonetablet, film coated2 mg/1oralAurobindo Pharma Limited2008-10-08Not applicableUs
Risperidonetablet, orally disintegrating4 mg/1oralPar Pharmaceutical Companies, Inc.2009-06-01Not applicableUs
Risperidonetablet, film coated4 mg/1oralMylan Institutional Inc.2008-10-06Not applicableUs
Risperidonetablet.25 mg/1oralTorrent Pharmaceuticals Limited2009-01-01Not applicableUs
Risperidonetablet, film coated4 mg/1oralAphena Pharma Solutions Tennessee, Llc2008-09-17Not applicableUs
Risperidonetablet.25 mg/1oralREMEDYREPACK INC.2011-03-28Not applicableUs
Risperidonetablet, orally disintegrating4 mg/1oralSandoz Inc2009-12-22Not applicableUs
Risperidonetablet2 mg/1oralRebel Distributors Corp2009-07-01Not applicableUs
Risperidonetablet, film coated2 mg/1oralAphena Pharma Solutions Tennessee, Llc2008-09-17Not applicableUs
Risperidonetablet, film coated4 mg/1oralAurobindo Pharma Limited2008-10-08Not applicableUs
Risperidonetablet, film coated.5 mg/1oralAmerican Health Packaging2008-12-02Not applicableUs
Risperidonetablet, film coated.5 mg/1oralMc Kesson Contract Packaging2011-10-13Not applicableUs
Risperidonetablet.5 mg/1oralApotex Corp2008-09-22Not applicableUs
Risperidonetablet, orally disintegrating3 mg/1oralDr. Reddy's Laboratories Limited2009-11-30Not applicableUs
Risperidonetablet, film coated.5 mg/1oralCardinal Health2010-11-122016-04-05Us
Risperidonetablet4 mg/1oralCaraco Pharmaceutical Laboratories, Ltd.2014-03-10Not applicableUs
Risperidonetablet, coated.5 mg/1oralRatiopharm Inc2010-06-08Not applicableUs
Risperidonesolution1 mg/mLoralRoxane Laboratories, Inc2009-07-29Not applicableUs
Risperidonetablet.25 mg/1oralBreckenridge Pharmaceutical, Inc.2012-04-25Not applicableUs
Risperidonetablet, film coated4 mg/1oralGen Source Rx2009-10-252016-03-29Us
Risperidonetablet, film coated3 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Risperidonetablet1 mg/1oralTorrent Pharmaceuticals Limited2009-01-01Not applicableUs
Risperidonetablet, film coated1 mg/1oralQualitest Pharmaceuticals2008-12-29Not applicableUs
Risperidonetablet, orally disintegrating4 mg/1oralJubilant Cadista Pharmaceuticals Inc.2010-12-01Not applicableUs
Risperidonetablet, film coated.25 mg/1oralProficient Rx LP2008-12-29Not applicableUs
Risperidonetablet, film coated3 mg/1oralbryant ranch prepack2008-12-29Not applicableUs
Risperidonesolution1 mg/mLoralAmneal Pharmaceuticals of New York, LLC2011-05-31Not applicableUs
Risperidonetablet, film coated1 mg/1oralREMEDYREPACK INC.2013-04-24Not applicableUs
Risperidonetablet, film coated1 mg/1oralAv Pak2014-08-27Not applicableUs
Risperidonetablet, film coated3 mg/1oralContract Pharmacy Services Pa2010-12-06Not applicableUs
Risperidonetablet, film coated.5 mg/1oralZydus Pharmaceuticals (USA) Inc.2008-11-13Not applicableUs
Risperidonetablet, film coated1 mg/1oralCardinal Health2010-11-122016-04-05Us
Risperidonetablet, film coated3 mg/1oralCardinal Health2008-10-24Not applicableUs
Risperidonetablet, film coated3 mg/1oralWockhardt Limited2008-10-09Not applicableUs
Risperidonetablet, film coated3 mg/1oralClinical Solutions Wholesale, Llc2008-11-13Not applicableUs
Risperidonetablet.5 mg/1oralHikma Pharmaceutical2009-06-01Not applicableUs
Risperidonetablet, film coated4 mg/1oralMylan Pharmaceuticals Inc.2008-09-15Not applicableUs
Risperidonesolution1 mg/mLoralBreckenridge Pharmaceutical, Inc.2014-01-29Not applicableUs
Risperidonetablet, film coated1 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Risperidonetablet, film coated.25 mg/1oralDr. Reddy's Laboratories Limited2009-10-24Not applicableUs
Risperidonetablet, film coated1 mg/1oralCobalt Laboratories2008-12-05Not applicableUs
Risperidonetablet, film coated.5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-07Not applicableUs
Risperidonetablet.25 mg/1oralREMEDYREPACK INC.2015-04-14Not applicableUs
Risperidonetablet, orally disintegrating3 mg/1oralRanbaxy Pharmaceuticals Inc.2010-08-06Not applicableUs
Risperidonetablet, film coated1 mg/1oralWOCKHARDT USA LLC2008-10-09Not applicableUs
Risperidonetablet, film coated1 mg/1oralCadila Healthcare Limited2008-11-13Not applicableUs
Risperidonetablet, film coated2 mg/1oralREMEDYREPACK INC.2013-05-01Not applicableUs
Risperidonetablet, orally disintegrating2 mg/1oralMylan Institutional Inc.2011-06-10Not applicableUs
Risperidonetablet4 mg/1oralMajor Pharmaceuticals2013-11-30Not applicableUs
Risperidonetablet2 mg/1oralAjanta Pharma Limited2015-09-09Not applicableUs
Risperidonetablet3 mg/1oralSolco Healthcare US, LLC2015-06-01Not applicableUs
Risperidonetablet, film coated.5 mg/1oralCardinal Health2008-11-13Not applicableUs
Risperidonetablet1 mg/1oralCaraco Pharmaceutical Laboratories, Ltd.2014-03-10Not applicableUs
Risperidonetablet, film coated4 mg/1oralClinical Solutions Wholesale2008-12-29Not applicableUs
Risperidonetablet, orally disintegrating1 mg/1oralJubilant Cadista Pharmaceuticals Inc.2010-12-01Not applicableUs
Risperidonetablet, orally disintegrating4 mg/1oralMylan Pharmaceuticals Inc.2011-05-11Not applicableUs
Risperidonetablet, film coated1 mg/1oralGen Source Rx2009-10-252016-03-29Us
Risperidonetablet, film coated2 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Risperidonetablet, orally disintegrating.5 mg/1oralDr. Reddy's Laboratories Limited2009-02-24Not applicableUs
Risperidonetablet.25 mg/1oralRebel Distributors Corp2009-07-01Not applicableUs
Risperidonetablet, orally disintegrating1 mg/1oralSandoz Inc2009-12-22Not applicableUs
Risperidonetablet, orally disintegrating.5 mg/1oralSun Pharmaceutical Industries Limited2013-04-13Not applicableUs
Risperidonetablet, film coated1 mg/1oralbryant ranch prepack2008-12-29Not applicableUs
Risperidonetablet, film coated1 mg/1oralTYA Pharmaceuticals2008-11-13Not applicableUs
Risperidonetablet, film coated1 mg/1oralAurobindo Pharma Limited2008-10-08Not applicableUs
Risperidonetablet, orally disintegrating3 mg/1oralPar Pharmaceutical Companies, Inc.2009-06-01Not applicableUs
Risperidonetablet, film coated3 mg/1oralMylan Institutional Inc.2008-10-06Not applicableUs
Risperidonetablet, film coated4 mg/1oralAurolife Pharma LLC2009-10-25Not applicableUs
Risperidonetablet1 mg/1oralPd Rx Pharmaceuticals, Inc.2009-01-01Not applicableUs
Risperidonetablet1 mg/1oralREMEDYREPACK INC.2013-04-30Not applicableUs
Risperidonetablet3 mg/1oralContract Pharmacy Services Pa2010-08-25Not applicableUs
Risperidonetablet, orally disintegrating1 mg/1oralZydus Pharmaceuticals (USA) Inc.2010-06-29Not applicableUs
Risperidonetablet, film coated2 mg/1oralMc Kesson Contract Packaging2011-09-14Not applicableUs
Risperidonetablet, film coated2 mg/1oralContract Pharmacy Services Pa2010-12-06Not applicableUs
Risperidonetablet, film coated.25 mg/1oralZydus Pharmaceuticals (USA) Inc.2008-11-13Not applicableUs
Risperidonetablet, film coated1 mg/1oralCardinal Health2012-09-19Not applicableUs
Risperidonetablet, film coated2 mg/1oralCardinal Health2008-10-24Not applicableUs
Risperidonetablet, film coated2 mg/1oralWockhardt Limited2008-10-09Not applicableUs
Risperidonetablet, film coated2 mg/1oralClinical Solutions Wholesale, Llc2008-11-13Not applicableUs
Risperidonetablet.25 mg/1oralHikma Pharmaceutical2009-06-01Not applicableUs
Risperidonetablet, film coated3 mg/1oralMylan Pharmaceuticals Inc.2008-09-15Not applicableUs
Risperidonetablet4 mg/1oralBreckenridge Pharmaceutical, Inc.2012-04-25Not applicableUs
Risperidonetablet, film coated2 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Risperidonetablet2 mg/1oralPhysicians Total Care, Inc2011-04-08Not applicableUs
Risperidonetablet, film coated.5 mg/1oralCobalt Laboratories2008-12-05Not applicableUs
Risperidonetablet, film coated.25 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-07Not applicableUs
Risperidonetablet2 mg/1oralREMEDYREPACK INC.2015-03-27Not applicableUs
Risperidonetablet2 mg/1oralProficient Rx LP2014-04-23Not applicableUs
Risperidonetablet, film coated.5 mg/1oralWOCKHARDT USA LLC2008-10-09Not applicableUs
Risperidonetablet, film coated.5 mg/1oralCadila Healthcare Limited2008-11-13Not applicableUs
Risperidonetablet, film coated.25 mg/1oralREMEDYREPACK INC.2013-05-01Not applicableUs
Risperidonetablet, orally disintegrating1 mg/1oralMylan Institutional Inc.2011-06-10Not applicableUs
Risperidonetablet3 mg/1oralMajor Pharmaceuticals2013-11-30Not applicableUs
Risperidonetablet.5 mg/1oralAjanta Pharma Limited2015-09-09Not applicableUs
Risperidonetablet2 mg/1oralSolco Healthcare US, LLC2015-06-01Not applicableUs
Risperidonetablet, film coated.25 mg/1oralCardinal Health2008-11-13Not applicableUs
Risperidonetablet.5 mg/1oralCaraco Pharmaceutical Laboratories, Ltd.2014-03-10Not applicableUs
Risperidonetablet, film coated2 mg/1oralClinical Solutions Wholesale2008-12-29Not applicableUs
Risperidonetablet, orally disintegrating.5 mg/1oralJubilant Cadista Pharmaceuticals Inc.2010-12-01Not applicableUs
Risperidonetablet, orally disintegrating3 mg/1oralMylan Pharmaceuticals Inc.2011-05-11Not applicableUs
Risperidonetablet, film coated.5 mg/1oralGen Source Rx2009-10-252016-03-29Us
Risperidonetablet, film coated2 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Risperidonetablet, film coated4 mg/1oralDr. Reddy's Laboratories Limited2009-10-24Not applicableUs
Risperidonesolution1 mg/mLoralAtlantic Biologicals Corps2011-05-31Not applicableUs
Risperidonetablet, orally disintegrating.5 mg/1oralSandoz Inc2009-12-22Not applicableUs
Risperidonetablet, orally disintegrating4 mg/1oralSun Pharmaceutical Industries Limited2013-04-13Not applicableUs
Risperidonetablet, film coated.25 mg/1oralbryant ranch prepack2008-12-29Not applicableUs
Risperidonetablet, film coated.5 mg/1oralTYA Pharmaceuticals2008-11-13Not applicableUs
Risperidonetablet, film coated.5 mg/1oralAurobindo Pharma Limited2008-10-08Not applicableUs
Risperidonetablet, orally disintegrating2 mg/1oralPar Pharmaceutical Companies, Inc.2009-06-01Not applicableUs
Risperidonetablet, film coated2 mg/1oralMylan Institutional Inc.2008-10-06Not applicableUs
Risperidonetablet, film coated3 mg/1oralAurolife Pharma LLC2009-10-25Not applicableUs
Risperidonetablet2 mg/1oralMsm Repackaging2015-09-09Not applicableUs
Risperidonetablet3 mg/1oralREMEDYREPACK INC.2011-05-05Not applicableUs
Risperidonetablet2 mg/1oralContract Pharmacy Services Pa2010-08-25Not applicableUs
Risperidonetablet, orally disintegrating.5 mg/1oralZydus Pharmaceuticals (USA) Inc.2010-06-29Not applicableUs
Risperidonetablet, film coated1 mg/1oralMc Kesson Contract Packaging2011-09-22Not applicableUs
Risperidonetablet, film coated1 mg/1oralCardinal Health2008-10-24Not applicableUs
Risperidonetablet, film coated1 mg/1oralWockhardt Limited2008-10-09Not applicableUs
Risperidonetablet, film coated1 mg/1oralClinical Solutions Wholesale, Llc2008-11-13Not applicableUs
Risperidonetablet, coated4 mg/1oralRatiopharm Inc2010-06-08Not applicableUs
Risperidonetablet, film coated2 mg/1oralMylan Pharmaceuticals Inc.2008-09-15Not applicableUs
Risperidonetablet3 mg/1oralBreckenridge Pharmaceutical, Inc.2012-04-25Not applicableUs
Risperidonetablet4 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Risperidonetablet.25 mg/1oralPhysicians Total Care, Inc2010-11-15Not applicableUs
Risperidonetablet, film coated.25 mg/1oralCobalt Laboratories2008-12-05Not applicableUs
Risperidonesolution1 mg/mLoralQualitest Pharmaceuticals2010-12-03Not applicableUs
Risperidonetablet.5 mg/1oralREMEDYREPACK INC.2015-03-17Not applicableUs
Risperidonetablet, film coated.25 mg/1oralProficient Rx LP2008-11-13Not applicableUs
Risperidonetablet, film coated.25 mg/1oralWOCKHARDT USA LLC2008-10-09Not applicableUs
Risperidonetablet, film coated.25 mg/1oralCadila Healthcare Limited2008-11-13Not applicableUs
Risperidonetablet, film coated.5 mg/1oralREMEDYREPACK INC.2013-04-23Not applicableUs
Risperidonetablet1 mg/1oralUnit Dose Services2009-01-01Not applicableUs
Risperidonetablet2 mg/1oralMajor Pharmaceuticals2013-11-30Not applicableUs
Risperidonetablet.25 mg/1oralAjanta Pharma Limited2015-09-09Not applicableUs
Risperidonetablet1 mg/1oralSolco Healthcare US, LLC2015-06-01Not applicableUs
Risperidonetablet, film coated1 mg/1oralContract Pharmacy Services Pa2010-12-06Not applicableUs
Risperidonetablet, film coated4 mg/1oralAmerican Health Packaging2008-12-02Not applicableUs
Risperidonetablet4 mg/1oralApotex Corp2008-09-22Not applicableUs
Risperidonetablet2 mg/1oralSTAT Rx USA LLC2009-01-01Not applicableUs
Risperidonetablet, film coated3 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-07Not applicableUs
Risperidonetablet, orally disintegrating3 mg/1oralSun Pharmaceutical Industries Limited2013-04-13Not applicableUs
Risperidonetablet, orally disintegrating2 mg/1oralRanbaxy Pharmaceuticals Inc.2010-08-06Not applicableUs
Risperidonesolution1 mg/mLoralWockhardt USA LLC.2009-10-14Not applicableUs
Risperidonetablet, film coated.25 mg/1oralAurobindo Pharma Limited2008-10-08Not applicableUs
Risperidonetablet, orally disintegrating1 mg/1oralPar Pharmaceutical Companies, Inc.2009-10-26Not applicableUs
Risperidonetablet, film coated1 mg/1oralMylan Institutional Inc.2008-10-06Not applicableUs
Risperidonetablet, film coated2 mg/1oralAurolife Pharma LLC2009-10-25Not applicableUs
Risperidonetablet1 mg/1oralAidarex Pharmaceuticals LLC2009-01-01Not applicableUs
Risperidonetablet.25 mg/1oralREMEDYREPACK INC.2013-04-24Not applicableUs
Risperidonetablet1 mg/1oralContract Pharmacy Services Pa2010-08-25Not applicableUs
Risperidonetablet, film coated4 mg/1oralZydus Pharmaceuticals (USA) Inc.2008-11-13Not applicableUs
Risperidonetablet.5 mg/1oralProficient Rx LP2015-09-09Not applicableUs
Risperidonetablet1 mg/1oralCardinal Health2013-11-30Not applicableUs
Risperidonetablet.25 mg/1oralCaraco Pharmaceutical Laboratories, Ltd.2014-03-10Not applicableUs
Risperidonetablet, film coated1 mg/1oralClinical Solutions Wholesale2008-12-29Not applicableUs
Risperidonetablet4 mg/1oralHikma Pharmaceutical2009-06-01Not applicableUs
Risperidonetablet, orally disintegrating2 mg/1oralMylan Pharmaceuticals Inc.2011-05-11Not applicableUs
Risperidonetablet, film coated.25 mg/1oralGen Source Rx2009-10-252016-03-29Us
Risperidonetablet, film coated.5 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Risperidonetablet, film coated3 mg/1oralDr. Reddy's Laboratories Limited2009-10-24Not applicableUs
Risperidonetablet, film coated.5 mg/1oralCardinal Health2008-10-24Not applicableUs
Risperidonetablet, film coated.5 mg/1oralWockhardt Limited2008-10-09Not applicableUs
Risperidonetablet3 mg/1oralClinical Solutions Wholesale, Llc2009-01-01Not applicableUs
Risperidonetablet, coated3 mg/1oralRatiopharm Inc2010-06-08Not applicableUs
Risperidonetablet, film coated1 mg/1oralMylan Pharmaceuticals Inc.2008-09-15Not applicableUs
Risperidonetablet2 mg/1oralBreckenridge Pharmaceutical, Inc.2012-04-25Not applicableUs
Risperidonetablet, film coated2 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Risperidonetablet.5 mg/1oralPhysicians Total Care, Inc2009-10-28Not applicableUs
Risperidonetablet4 mg/1oralTorrent Pharmaceuticals Limited2009-01-01Not applicableUs
Risperidonetablet, film coated3 mg/1oralQualitest Pharmaceuticals2008-12-29Not applicableUs
Risperidonetablet1 mg/1oralREMEDYREPACK INC.2015-03-12Not applicableUs
Risperidonetablet1 mg/1oralProficient Rx LP2014-04-23Not applicableUs
Risperidonetablet, film coated2 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2012-03-19Not applicableUs
Risperidonetablet, orally disintegrating2 mg/1oralCadila Healthcare Limited2010-06-29Not applicableUs
Risperidonetablet, film coated4 mg/1oralREMEDYREPACK INC.2013-04-23Not applicableUs
Risperidonetablet, film coated4 mg/1oralAv Pak2014-08-27Not applicableUs
Risperidonetablet1 mg/1oralMajor Pharmaceuticals2013-11-30Not applicableUs
Risperidonetablet1 mg/1oralAjanta Pharma Limited2015-09-09Not applicableUs
Risperidonetablet.5 mg/1oralSolco Healthcare US, LLC2015-06-01Not applicableUs
Risperidonetablet, film coated.5 mg/1oralContract Pharmacy Services Pa2010-12-06Not applicableUs
Risperidonetablet, film coated3 mg/1oralAmerican Health Packaging2008-12-02Not applicableUs
Risperidonetablet3 mg/1oralApotex Corp2008-09-22Not applicableUs
Risperidonetablet, film coated1 mg/1oralDIRECT RX2014-01-01Not applicableUs
Risperidonetablet, orally disintegrating1 mg/1oralRanbaxy Pharmaceuticals Inc.2010-08-06Not applicableUs
Risperidonetablet, film coated4 mg/1oralWOCKHARDT USA LLC2008-10-09Not applicableUs
Risperidonetablet, film coated4 mg/1oralCadila Healthcare Limited2008-11-13Not applicableUs
Risperidonetablet, orally disintegrating.5 mg/1oralPar Pharmaceutical Companies, Inc.2009-06-01Not applicableUs
Risperidonetablet, film coated.5 mg/1oralMylan Institutional Inc.2008-10-06Not applicableUs
Risperidonetablet, film coated1 mg/1oralAurolife Pharma LLC2009-10-25Not applicableUs
Risperidonesolution1 mg/mLoralTris Pharma Inc2012-12-12Not applicableUs
Risperidonetablet.5 mg/1oralREMEDYREPACK INC.2011-04-11Not applicableUs
Risperidonetablet.5 mg/1oralContract Pharmacy Services Pa2010-08-25Not applicableUs
Risperidonetablet, film coated3 mg/1oralZydus Pharmaceuticals (USA) Inc.2008-11-13Not applicableUs
Risperidonetablet, film coated1 mg/1oralCardinal Health2008-12-02Not applicableUs
Risperidonetablet, film coated2 mg/1oralLake Erie Medical DBA Quality Care Products LLC2013-06-18Not applicableUs
Risperidonetablet, film coated.5 mg/1oralClinical Solutions Wholesale2008-12-29Not applicableUs
Risperidonetablet3 mg/1oralHikma Pharmaceutical2009-06-01Not applicableUs
Risperidonetablet, orally disintegrating1 mg/1oralMylan Pharmaceuticals Inc.2011-05-11Not applicableUs
Risperidonetablet, film coated1 mg/1oralREMEDYREPACK INC.2013-05-08Not applicableUs
Risperidonetablet3 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Risperidonetablet, film coated2 mg/1oralDr. Reddy's Laboratories Limited2009-10-24Not applicableUs
Risperidonetablet, film coated4 mg/1oralCobalt Laboratories2008-12-05Not applicableUs
Risperidonetablet, film coated2 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-07Not applicableUs
Risperidonetablet, film coated4 mg/1oralQualitest Pharmaceuticals2008-12-29Not applicableUs
Risperidonetablet3 mg/1oralREMEDYREPACK INC.2015-03-03Not applicableUs
Risperidonetablet, film coated2 mg/1oralProficient Rx LP2008-12-29Not applicableUs
Risperidonetablet, film coated1 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2012-02-13Not applicableUs
Risperidonetablet, orally disintegrating1 mg/1oralCadila Healthcare Limited2010-06-29Not applicableUs
Risperidonetablet, film coated4 mg/1oralREMEDYREPACK INC.2013-05-01Not applicableUs
Risperidonetablet, film coated3 mg/1oralAv Pak2014-08-27Not applicableUs
Risperidonetablet.5 mg/1oralMajor Pharmaceuticals2013-11-30Not applicableUs
Risperidonesolution1 mg/mLoralHeritage Pharmaceuticals Inc.2013-07-15Not applicableUs
Risperidonetablet.25 mg/1oralSolco Healthcare US, LLC2015-06-01Not applicableUs
Risperidonetablet, film coated.25 mg/1oralContract Pharmacy Services Pa2010-12-06Not applicableUs
Risperidonetablet, film coated2 mg/1oralAmerican Health Packaging2008-12-02Not applicableUs
Risperidonetablet2 mg/1oralREMEDYREPACK INC.2015-12-23Not applicableUs
Risperidonetablet2 mg/1oralApotex Corp2008-09-22Not applicableUs
Risperidonesolution1 mg/mLoralDr. Reddy's Laboratories Limited2009-07-29Not applicableUs
Risperidonetablet, film coated.25 mg/1oralWockhardt Limited2008-10-09Not applicableUs
Risperidonetablet2 mg/1oralClinical Solutions Wholesale, Llc2009-01-01Not applicableUs
Risperidonetablet, coated2 mg/1oralRatiopharm Inc2010-06-08Not applicableUs
Risperidonetablet, film coated.5 mg/1oralMylan Pharmaceuticals Inc.2008-09-15Not applicableUs
Risperidonetablet1 mg/1oralBreckenridge Pharmaceutical, Inc.2012-04-25Not applicableUs
Risperidonetablet2 mg/1oralH.J. Harkins Company, Inc.2009-01-01Not applicableUs
Risperidonetablet1 mg/1oralPhysicians Total Care, Inc2008-07-23Not applicableUs
Risperidonetablet3 mg/1oralTorrent Pharmaceuticals Limited2009-01-01Not applicableUs
Risperidonetablet, film coated.5 mg/1oralAurolife Pharma LLC2009-10-25Not applicableUs
Risperidonetablet4 mg/1oralAjanta Pharma Limited2015-09-09Not applicableUs
Risperidonetablet3 mg/1oralREMEDYREPACK INC.2010-11-08Not applicableUs
Risperidonetablet.25 mg/1oralContract Pharmacy Services Pa2010-08-25Not applicableUs
Risperidonetablet, film coated2 mg/1oralZydus Pharmaceuticals (USA) Inc.2008-11-13Not applicableUs
Risperidonetablet, film coated3 mg/1oralCardinal Health2010-11-122016-04-05Us
Risperidonetablet, film coated.25 mg/1oralCardinal Health2008-10-24Not applicableUs
Risperidonesolution1 mg/mLoralWockhardt Limited2009-10-14Not applicableUs
Risperidonetablet, film coated.25 mg/1oralClinical Solutions Wholesale2008-12-29Not applicableUs
Risperidonetablet2 mg/1oralHikma Pharmaceutical2009-06-01Not applicableUs
Risperidonetablet, orally disintegrating.5 mg/1oralMylan Pharmaceuticals Inc.2011-05-11Not applicableUs
Risperidonetablet, film coated.5 mg/1oralREMEDYREPACK INC.2013-03-182016-04-05Us
Risperidonetablet2 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Risperidonetablet, film coated1 mg/1oralDr. Reddy's Laboratories Limited2009-10-24Not applicableUs
Risperidonetablet, film coated3 mg/1oralCobalt Laboratories2008-12-05Not applicableUs
Risperidonetablet, film coated4 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-07Not applicableUs
Risperidonetablet1 mg/1oralREMEDYREPACK INC.2015-12-30Not applicableUs
Risperidonetablet, orally disintegrating.5 mg/1oralRanbaxy Pharmaceuticals Inc.2010-08-06Not applicableUs
Risperidonetablet, film coated3 mg/1oralWOCKHARDT USA LLC2008-10-09Not applicableUs
Risperidonetablet, film coated3 mg/1oralCadila Healthcare Limited2008-11-13Not applicableUs
Risperidonetablet, orally disintegrating.25 mg/1oralPar Pharmaceutical Companies, Inc.2009-06-01Not applicableUs
Risperidonetablet, film coated.25 mg/1oralMylan Institutional Inc.2008-10-06Not applicableUs
Risperidonetablet, film coated1 mg/1oralAphena Pharma Solutions Tennessee, Llc2008-09-17Not applicableUs
Risperidonetablet, film coated2 mg/1oralREMEDYREPACK INC.2013-05-01Not applicableUs
Risperidonetablet, film coated.25 mg/1oralAmerican Health Packaging2008-12-02Not applicableUs
Risperidonetablet, film coated.25 mg/1oralMc Kesson Contract Packaging2011-10-13Not applicableUs
Risperidonetablet.25 mg/1oralApotex Corp2008-09-22Not applicableUs
Risperidonetablet, film coated.25 mg/1oralCardinal Health2010-11-122016-04-05Us
Risperidonetablet3 mg/1oralCaraco Pharmaceutical Laboratories, Ltd.2014-03-10Not applicableUs
Risperidonetablet, coated.25 mg/1oralRatiopharm Inc2010-06-08Not applicableUs
Risperidonetablet, orally disintegrating3 mg/1oralJubilant Cadista Pharmaceuticals Inc.2010-12-01Not applicableUs
Risperidonetablet, film coated.5 mg/1oralQualitest Pharmaceuticals2008-12-29Not applicableUs
Risperidonetablet, film coated3 mg/1oralGen Source Rx2009-10-252016-03-29Us
Risperidonetablet3 mg/1oralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
Risperidonetablet, orally disintegrating2 mg/1oralDr. Reddy's Laboratories Limited2009-02-24Not applicableUs
Risperidonetablet1 mg/1oralRebel Distributors Corp2009-07-01Not applicableUs
Risperidonetablet, orally disintegrating3 mg/1oralSandoz Inc2009-12-22Not applicableUs
Risperidonetablet, orally disintegrating2 mg/1oralSun Pharmaceutical Industries Limited2013-04-13Not applicableUs
Risperidonetablet, film coated.5 mg/1oralbryant ranch prepack2008-12-29Not applicableUs
Risperidonetablet4 mg/1oralTYA Pharmaceuticals2012-04-25Not applicableUs
Risperidonetablet, film coated3 mg/1oralAurobindo Pharma Limited2008-10-08Not applicableUs
Risperidonetablet, film coated.5 mg/1oralAv Pak2014-08-27Not applicableUs
Risperidonesolution1 mg/mLoralTaro Pharmaceuticals U.S.A., Inc.2011-02-07Not applicableUs
Risperidonetablet.5 mg/1oralTorrent Pharmaceuticals Limited2009-01-01Not applicableUs
Risperidonesolution1 mg/mLoralApotex Corp.2009-07-29Not applicableUs
Risperidonetablet, film coated.5 mg/1oralProficient Rx LP2008-12-29Not applicableUs
Risperidonetablet, film coated4 mg/1oralbryant ranch prepack2008-12-29Not applicableUs
Risperidonetablet, orally disintegrating.5 mg/1oralCadila Healthcare Limited2010-06-29Not applicableUs
Risperidonetablet, film coated3 mg/1oralREMEDYREPACK INC.2013-04-23Not applicableUs
Risperidonetablet, film coated2 mg/1oralAv Pak2014-08-27Not applicableUs
Risperidonetablet.25 mg/1oralMajor Pharmaceuticals2013-11-30Not applicableUs
Risperidonetablet3 mg/1oralRebel Distributors Corp2009-07-01Not applicableUs
Risperidonetablet, film coated3 mg/1oralAphena Pharma Solutions Tennessee, Llc2008-09-17Not applicableUs
Risperidonesolution1 mg/mLoralAurobindo Pharma Limited2009-09-15Not applicableUs
Risperidonetablet, film coated1 mg/1oralAmerican Health Packaging2008-12-02Not applicableUs
Risperidonetablet, film coated4 mg/1oralMc Kesson Contract Packaging2013-05-13Not applicableUs
Risperidonetablet1 mg/1oralApotex Corp2008-09-22Not applicableUs
Risperidonetablet, orally disintegrating4 mg/1oralDr. Reddy's Laboratories Limited2009-11-30Not applicableUs
Risperidonetablet.25 mg/1oralCardinal Health2013-11-30Not applicableUs
Risperidonetablet1 mg/1oralClinical Solutions Wholesale, Llc2009-01-01Not applicableUs
Risperidonetablet, coated1 mg/1oralRatiopharm Inc2010-06-08Not applicableUs
Risperidonetablet, film coated.25 mg/1oralMylan Pharmaceuticals Inc.2008-09-15Not applicableUs
Risperidonetablet.5 mg/1oralBreckenridge Pharmaceutical, Inc.2012-04-25Not applicableUs
Risperidonetablet.5 mg/1oralH.J. Harkins Company, Inc.2009-01-01Not applicableUs
Risperidonesolution1 mg/mLoralSilarx Pharmaceuticals, Inc2015-01-30Not applicableUs
Risperidonetablet2 mg/1oralTorrent Pharmaceuticals Limited2009-01-01Not applicableUs
Risperidonetablet, film coated2 mg/1oralQualitest Pharmaceuticals2008-12-29Not applicableUs
Risperidonetablet3 mg/1oralAjanta Pharma Limited2015-09-09Not applicableUs
Risperidonetablet4 mg/1oralSolco Healthcare US, LLC2015-06-01Not applicableUs
Risperidonetablet, film coated4 mg/1oralContract Pharmacy Services Pa2010-12-06Not applicableUs
Risperidonetablet, film coated1 mg/1oralZydus Pharmaceuticals (USA) Inc.2008-11-13Not applicableUs
Risperidonetablet, film coated2 mg/1oralCardinal Health2010-11-122016-04-05Us
Risperidonetablet, film coated4 mg/1oralCardinal Health2008-10-24Not applicableUs
Risperidonetablet, film coated4 mg/1oralWockhardt Limited2008-10-09Not applicableUs
Risperidonetablet, film coated4 mg/1oralClinical Solutions Wholesale, Llc2008-11-13Not applicableUs
Risperidonetablet1 mg/1oralHikma Pharmaceutical2009-06-01Not applicableUs
Risperidonetablet, orally disintegrating.25 mg/1oralMylan Pharmaceuticals Inc.2013-03-11Not applicableUs
Risperidonetablet, film coated.5 mg/1oralREMEDYREPACK INC.2013-03-05Not applicableUs
Risperidonetablet1 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Risperidonetablet, film coated.5 mg/1oralDr. Reddy's Laboratories Limited2009-10-24Not applicableUs
Risperidonetablet, film coated2 mg/1oralCobalt Laboratories2008-12-05Not applicableUs
Risperidonetablet, film coated1 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-07Not applicableUs
Risperidonetablet4 mg/1oralREMEDYREPACK INC.2015-04-14Not applicableUs
Risperidonetablet, orally disintegrating4 mg/1oralRanbaxy Pharmaceuticals Inc.2010-08-06Not applicableUs
Risperidonetablet, film coated2 mg/1oralWOCKHARDT USA LLC2008-10-09Not applicableUs
Risperidonetablet, film coated2 mg/1oralCadila Healthcare Limited2008-11-13Not applicableUs
Risperidonetablet, film coated3 mg/1oralREMEDYREPACK INC.2013-05-01Not applicableUs
Risperidonetablet, orally disintegrating3 mg/1oralMylan Institutional Inc.2011-06-10Not applicableUs
Risperidonetablet, film coated.25 mg/1oralAurolife Pharma LLC2009-10-25Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
Risperidal M-TabJanssen
RisperinNot Available
RispoleptNot Available
RispolinNot Available
SequinanNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIL6UH7ZF8HC
CAS number106266-06-2
WeightAverage: 410.4845
Monoisotopic: 410.211804333
Chemical FormulaC23H27FN4O2
InChI KeyInChIKey=RAPZEAPATHNIPO-UHFFFAOYSA-N
InChI
InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3
IUPAC Name
3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-4H,6H,7H,8H,9H-pyrido[1,2-a]pyrimidin-4-one
SMILES
CC1=C(CCN2CCC(CC2)C2=NOC3=C2C=CC(F)=C3)C(=O)N2CCCCC2=N1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as pyridopyrimidines. These are compounds containing a pyridopyrimidine, which consists of a pyridine fused to a pyrimidine. Pyridine is 6-membered ring consisting of five carbon atoms and a nitrogen atom. Pyrimidine is a 6-membered ring consisting of four carbon atoms and two nitrogen centers at the 1- and 3- ring positions.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassPyridopyrimidines
Sub ClassNot Available
Direct ParentPyridopyrimidines
Alternative Parents
Substituents
  • Pyridopyrimidine
  • Benzisoxazole
  • Aralkylamine
  • Pyrimidone
  • Fluorobenzene
  • Benzenoid
  • Pyrimidine
  • Pyridine
  • Piperidine
  • Aryl halide
  • Aryl fluoride
  • Heteroaromatic compound
  • Oxazole
  • Isoxazole
  • Azole
  • Tertiary aliphatic amine
  • Tertiary amine
  • Lactam
  • Oxacycle
  • Azacycle
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organofluoride
  • Organohalogen compound
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of schizophrenia in adults and in adolescents, ages 13 to 17, and for the short-term treatment of manic or mixed episodes of bipolar I disorder in children and adolescents ages 10 to 17. May also be used to manage symptoms of inappropriate behavior due to aggression and/or psychosis in patients with severe dementia.
PharmacodynamicsRisperidone is an atypical antipsychotic medication. It is most often used to treat delusional psychosis (including schizophrenia), but risperidone is also used to treat some forms of bipolar disorder and psychotic depression. It also has shown some success in treating symptoms of Asperger's Syndrome and autism. Risperidone is now the most commonly prescribed antipsychotic medication in the United States.
Mechanism of actionBlockade of dopaminergic D2 receptors in the limbic system alleviates positive symptoms of schizophrenia such as hallucinations, delusions, and erratic behavior and speech. Blockade of serotonergic 5-HT2 receptors in the mesocortical tract, causes an excess of dopamine and an increase in dopamine transmission, resulting in an increase in dopamine transmission and an elimination of core negative symptoms. Dopamine receptors in the nigrostriatal pathway are not affected by risperidone and extrapyramidal effects are avoided. Like other 5-HT2 antagonists, risperidone also binds at alpha(1)-adrenergic receptors and, to a lesser extent, at histamine H1 and alpha(2)-adrenergic receptors.
Related Articles
AbsorptionWell absorbed. The absolute oral bioavailability of risperidone is 70% (CV=25%). The relative oral bioavailability of risperidone from a tablet is 94% (CV=10%) when compared to a solution.
Volume of distribution
  • 1 to 2 L/kg
Protein bindingRisperidone, ~88% bound; 9-hydroxyrisperidone, ~77% bound.
Metabolism

Extensively metabolized by hepatic cytochrome P450 2D6 isozyme to 9-hydroxyrisperidone, which has approximately the same receptor binding affinity as risperidone. Hydroxylation is dependent on debrisoquine 4-hydroxylase and metabolism is sensitive to genetic polymorphisms in debrisoquine 4-hydroxylase. Risperidone also undergoes N-dealkylation to a lesser extent.

SubstrateEnzymesProduct
Risperidone
9-hydroxyrisperidoneDetails
Route of eliminationRisperidone is extensively metabolized in the liver.In healthy elderly subjects, renal clearance of both risperidone and 9-hydroxyrisperidone was decreased, and elimination half-lives were prolonged compared to young healthy subjects.
Half life20-24 hours
ClearanceNot Available
ToxicitySymptoms of overdose include drowsiness, sedation, tachycardia, hypotension, and extrapyramidal symptoms. LD50=82.1mg/kg (orally in mice).
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.9925
Caco-2 permeable-0.5057
P-glycoprotein substrateSubstrate0.6163
P-glycoprotein inhibitor IInhibitor0.8564
P-glycoprotein inhibitor IIInhibitor0.9361
Renal organic cation transporterInhibitor0.6491
CYP450 2C9 substrateNon-substrate0.8235
CYP450 2D6 substrateSubstrate0.8918
CYP450 3A4 substrateSubstrate0.7407
CYP450 1A2 substrateNon-inhibitor0.9046
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorInhibitor0.8931
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorNon-inhibitor0.82
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.8459
Ames testNon AMES toxic0.5302
CarcinogenicityNon-carcinogens0.8204
BiodegradationNot ready biodegradable0.99
Rat acute toxicity3.8290 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.65
hERG inhibition (predictor II)Inhibitor0.8062
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Ortho mcneil janssen pharmaceuticals inc
  • Ortho mcneil janssen pharmaceutical inc
  • Apotex inc richmond hill
  • Aurobindo pharma ltd
  • Dr reddys laboratories ltd
  • Precision dose inc
  • Roxane laboratories inc
  • Teva pharmaceuticals usa inc
  • Wockhardt ltd
  • Par pharmaceutical inc
  • Ranbaxy laboratories inc
  • Sandoz inc
  • Zydus pharmaceuticals usa inc
  • Actavis totowa llc
  • Apotex inc
  • Cadista pharmaceuticals inc
  • Mylan pharmaceuticals inc
  • Pliva hrvatska doo
  • Ratiopharm
  • Synthon pharmaceuticals inc
  • Torrent pharmaceuticals ltd
  • Vintage pharmaceuticals llc
  • Watson laboratories inc
  • West ward pharmaceuticals corp
Packagers
Dosage forms
FormRouteStrength
Tabletoral0.50 mg
Tabletoral1.0 mg
Tabletoral2.0 mg
Tabletoral3.0 mg
Tabletoral4.0 mg
Tabletoral0.25 mg
Tabletoral0.5 mg
Tabletoral1 mg
Tabletoral2 mg
Tabletoral3 mg
Tabletoral4 mg
Tabletoral5 mg
Kit
Powder for suspension, sustained-release; kitintramuscular12.5 mg
Powder for suspension, sustained-release; kitintramuscular25 mg
Powder for suspension, sustained-release; kitintramuscular37.5 mg
Powder for suspension, sustained-release; kitintramuscular50 mg
Tablet (orally disintegrating)oral0.5 mg
Tablet (orally disintegrating)oral1 mg
Tablet (orally disintegrating)oral2 mg
Tablet (orally disintegrating)oral3 mg
Tablet (orally disintegrating)oral4 mg
Solutionoral1 mg
Solutionoral1 mg/mL
Tabletoral.25 mg/1
Tabletoral.5 mg/1
Tabletoral1 mg/1
Tabletoral2 mg/1
Tabletoral3 mg/1
Tabletoral4 mg/1
Tablet, coatedoral.25 mg/1
Tablet, coatedoral.5 mg/1
Tablet, coatedoral1 mg/1
Tablet, coatedoral2 mg/1
Tablet, coatedoral3 mg/1
Tablet, coatedoral4 mg/1
Tablet, film coatedoral.25 mg/1
Tablet, film coatedoral.5 mg/1
Tablet, film coatedoral1 mg/1
Tablet, film coatedoral2 mg/1
Tablet, film coatedoral3 mg/1
Tablet, film coatedoral4 mg/1
Tablet, orally disintegratingoral.25 mg/1
Tablet, orally disintegratingoral.5 mg/1
Tablet, orally disintegratingoral1 mg/1
Tablet, orally disintegratingoral2 mg/1
Tablet, orally disintegratingoral3 mg/1
Tablet, orally disintegratingoral4 mg/1
Prices
Unit descriptionCostUnit
Risperdal consta 50 mg syr592.93USD syringe
Risperdal consta 37.5 mg syr444.68USD syringe
Risperdal consta 25 mg syr296.46USD syringe
Risperdal 1 mg/ml Solution 30ml Bottle204.42USD bottle
Risperdal M-TAB 28 1 mg Dispersible Tablet Box196.08USD box
Risperdal M-TAB 28 0.5 mg Dispersible Tablet Bottle167.82USD bottle
Risperidone 1 mg/ml Solution 30ml Bottle158.66USD bottle
Risperdal consta 12.5 mg syr148.22USD syringe
Risperdal m-tab 4 mg odt18.55USD tablet
Risperdal 4 mg tablet16.47USD tablet
Risperidone m-tab 4 mg odt15.16USD tablet
Risperdal m-tab 3 mg odt13.81USD tablet
Risperdal 3 mg tablet11.45USD tablet
Risperidone m-tab 3 mg odt11.29USD tablet
Risperdal m-tab 2 mg odt10.95USD tablet
Risperidone 4 mg tablet9.0USD tablet
Risperidone m-tab 2 mg odt8.95USD tablet
Risperdal 2 mg tablet6.94USD tablet
Risperdal m-tab 1 mg odt6.73USD tablet
Risperidone 3 mg tablet6.63USD tablet
Risperdal 1 mg tablet6.12USD tablet
Risperdal m-tab 0.5 mg odt5.76USD tablet
Risperidone 2 mg tablet5.59USD tablet
Risperidone m-tab 1 mg odt5.5USD tablet
Risperidone M-TAB 0.5 mg Dispersible Tablet4.9USD dispersible tablet
Risperidone m-tab 0.5 mg odt4.71USD tablet
Risperdal M-Tab 4 mg Disintegrating Tablet4.6USD tablet
Risperdal 0.25 mg tablet4.56USD tablet
Risperidone 0.25 mg odt4.48USD tablet
Risperdal 0.5 mg tablet3.62USD tablet
Risperdal M-Tab 3 mg Disintegrating Tablet3.44USD tablet
Risperidone 1 mg tablet3.27USD tablet
Risperidone 0.5 mg tablet3.03USD tablet
Apo-Risperidone 4 mg Tablet2.53USD tablet
Co Risperidone 4 mg Tablet2.53USD tablet
Mylan-Risperidone 4 mg Tablet2.53USD tablet
Novo-Risperidone 4 mg Tablet2.53USD tablet
Phl-Risperidone 4 mg Tablet2.53USD tablet
Pms-Risperidone 4 mg Tablet2.53USD tablet
Ran-Risperidone 4 mg Tablet2.53USD tablet
Ratio-Risperidone 4 mg Tablet2.53USD tablet
Rbx-Risperidone 4 mg Tablet2.53USD tablet
Sandoz Risperidone 4 mg Tablet2.53USD tablet
Risperdal M-Tab 2 mg Disintegrating Tablet2.29USD tablet
Apo-Risperidone 3 mg Tablet1.9USD tablet
Co Risperidone 3 mg Tablet1.9USD tablet
Mylan-Risperidone 3 mg Tablet1.9USD tablet
Novo-Risperidone 3 mg Tablet1.9USD tablet
Phl-Risperidone 3 mg Tablet1.9USD tablet
Pms-Risperidone 3 mg Tablet1.9USD tablet
Ran-Risperidone 3 mg Tablet1.9USD tablet
Ratio-Risperidone 3 mg Tablet1.9USD tablet
Rbx-Risperidone 3 mg Tablet1.9USD tablet
Sandoz Risperidone 3 mg Tablet1.9USD tablet
Risperidone 0.25 mg tablet1.88USD tablet
Apo-Risperidone 2 mg Tablet1.26USD tablet
Co Risperidone 2 mg Tablet1.26USD tablet
Mylan-Risperidone 2 mg Tablet1.26USD tablet
Novo-Risperidone 2 mg Tablet1.26USD tablet
Phl-Risperidone 2 mg Tablet1.26USD tablet
Pms-Risperidone 2 mg Tablet1.26USD tablet
Ran-Risperidone 2 mg Tablet1.26USD tablet
Ratio-Risperidone 2 mg Tablet1.26USD tablet
Rbx-Risperidone 2 mg Tablet1.26USD tablet
Sandoz Risperidone 2 mg Tablet1.26USD tablet
Risperdal M-Tab 1 mg Disintegrating Tablet1.16USD tablet
Risperdal M-Tab 0.5 mg Disintegrating Tablet0.84USD tablet
Apo-Risperidone 1 mg Tablet0.63USD tablet
Co Risperidone 1 mg Tablet0.63USD tablet
Mylan-Risperidone 1 mg Tablet0.63USD tablet
Novo-Risperidone 1 mg Tablet0.63USD tablet
Phl-Risperidone 1 mg Tablet0.63USD tablet
Pms-Risperidone 1 mg Tablet0.63USD tablet
Ran-Risperidone 1 mg Tablet0.63USD tablet
Ratio-Risperidone 1 mg Tablet0.63USD tablet
Rbx-Risperidone 1 mg Tablet0.63USD tablet
Sandoz Risperidone 1 mg Tablet0.63USD tablet
Apo-Risperidone 0.5 mg Tablet0.46USD tablet
Co Risperidone 0.5 mg Tablet0.46USD tablet
Mylan-Risperidone 0.5 mg Tablet0.46USD tablet
Novo-Risperidone 0.5 mg Tablet0.46USD tablet
Phl-Risperidone 0.5 mg Tablet0.46USD tablet
Pms-Risperidone 0.5 mg Tablet0.46USD tablet
Ran-Risperidone 0.5 mg Tablet0.46USD tablet
Ratio-Risperidone 0.5 mg Tablet0.46USD tablet
Rbx-Risperidone 0.5 mg Tablet0.46USD tablet
Sandoz Risperidone 0.5 mg Tablet0.46USD tablet
Apo-Risperidone 0.25 mg Tablet0.27USD tablet
Co Risperidone 0.25 mg Tablet0.27USD tablet
Mylan-Risperidone 0.25 mg Tablet0.27USD tablet
Novo-Risperidone 0.25 mg Tablet0.27USD tablet
Phl-Risperidone 0.25 mg Tablet0.27USD tablet
Pms-Risperidone 0.25 mg Tablet0.27USD tablet
Ran-Risperidone 0.25 mg Tablet0.27USD tablet
Ratio-Risperidone 0.25 mg Tablet0.27USD tablet
Rbx-Risperidone 0.25 mg Tablet0.27USD tablet
Sandoz Risperidone 0.25 mg Tablet0.27USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2194564 No1998-01-272015-07-04Canada
CA2406536 No2009-12-222021-04-19Canada
US5792477 Yes1997-11-022017-11-02Us
US5916598 Yes1997-11-022017-11-02Us
US6110921 No1993-11-192013-11-19Us
US6194006 Yes1999-06-302019-06-30Us
US6224905 Yes1997-12-102017-12-10Us
US6379703 Yes1999-06-302019-06-30Us
US6403114 Yes1997-11-022017-11-02Us
US6596316 Yes1999-06-302019-06-30Us
US6667061 Yes2000-11-252020-11-25Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point170 °CPhysProp
water solubility2.8mg/LNot Available
logP2.5Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.171 mg/mLALOGPS
logP3.27ALOGPS
logP2.63ChemAxon
logS-3.4ALOGPS
pKa (Strongest Basic)8.76ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area61.94 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity114.55 m3·mol-1ChemAxon
Polarizability45.27 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

DrugSyn.org

US4804663
General References
  1. Altschuler EL, Kast RE: The atypical antipsychotic agents ziprasidone [correction of zisprasidone], risperdone and olanzapine as treatment for and prophylaxis against progressive multifocal leukoencephalopathy. Med Hypotheses. 2005;65(3):585-6. [PubMed:16004936 ]
  2. Bostwick JR, Guthrie SK, Ellingrod VL: Antipsychotic-induced hyperprolactinemia. Pharmacotherapy. 2009 Jan;29(1):64-73. doi: 10.1592/phco.29.1.64. [PubMed:19113797 ]
  3. Fenton C, Scott LJ: Risperidone: a review of its use in the treatment of bipolar mania. CNS Drugs. 2005;19(5):429-44. [PubMed:15907153 ]
  4. Kemp DE, Canan F, Goldstein BI, McIntyre RS: Long-acting risperidone: a review of its role in the treatment of bipolar disorder. Adv Ther. 2009 Jun;26(6):588-99. doi: 10.1007/s12325-009-0039-0. Epub 2009 Jun 26. [PubMed:19562274 ]
  5. Szarfman A, Tonning JM, Levine JG, Doraiswamy PM: Atypical antipsychotics and pituitary tumors: a pharmacovigilance study. Pharmacotherapy. 2006 Jun;26(6):748-58. [PubMed:16716128 ]
  6. Urichuk L, Prior TI, Dursun S, Baker G: Metabolism of atypical antipsychotics: involvement of cytochrome p450 enzymes and relevance for drug-drug interactions. Curr Drug Metab. 2008 Jun;9(5):410-8. [PubMed:18537577 ]
  7. Yamanouchi Y, Iwata N, Suzuki T, Kitajima T, Ikeda M, Ozaki N: Effect of DRD2, 5-HT2A, and COMT genes on antipsychotic response to risperidone. Pharmacogenomics J. 2003;3(6):356-61. [PubMed:14610521 ]
External Links
ATC CodesN05AX08
AHFS Codes
  • 28:16.08.04
PDB EntriesNot Available
FDA labelDownload (2.54 MB)
MSDSNot Available
Interactions
Drug Interactions
Drug
AbirateroneThe serum concentration of Risperidone can be increased when it is combined with Abiraterone.
AcebutololAcebutolol may increase the hypotensive activities of Risperidone.
AcetazolamideAcetazolamide may increase the hypotensive activities of Risperidone.
AcetohexamideThe therapeutic efficacy of Acetohexamide can be decreased when used in combination with Risperidone.
AclidiniumAclidinium may increase the anticholinergic activities of Risperidone.
AldesleukinAldesleukin may increase the hypotensive activities of Risperidone.
AliskirenAliskiren may increase the hypotensive activities of Risperidone.
AlmotriptanThe risk or severity of adverse effects can be increased when Almotriptan is combined with Risperidone.
AlogliptinThe therapeutic efficacy of Alogliptin can be decreased when used in combination with Risperidone.
AmilorideAmiloride may increase the hypotensive activities of Risperidone.
AmisulprideThe risk or severity of adverse effects can be increased when Risperidone is combined with Amisulpride.
AmitriptylineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Risperidone.
AmlodipineAmlodipine may increase the hypotensive activities of Risperidone.
AmoxapineThe risk or severity of adverse effects can be increased when Amoxapine is combined with Risperidone.
AmphetamineRisperidone may decrease the stimulatory activities of Amphetamine.
Amyl NitriteAmyl Nitrite may increase the hypotensive activities of Risperidone.
ApraclonidineApraclonidine may increase the hypotensive activities of Risperidone.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Risperidone.
AtenololAtenolol may increase the hypotensive activities of Risperidone.
AzelastineRisperidone may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Azilsartan medoxomilAzilsartan medoxomil may increase the hypotensive activities of Risperidone.
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Risperidone.
BenazeprilBenazepril may increase the hypotensive activities of Risperidone.
BenzphetamineRisperidone may decrease the stimulatory activities of Benzphetamine.
BetaxololBetaxolol may increase the hypotensive activities of Risperidone.
BisoprololBisoprolol may increase the hypotensive activities of Risperidone.
Botulinum Toxin Type ARisperidone may increase the anticholinergic activities of Botulinum Toxin Type A.
Botulinum Toxin Type BRisperidone may increase the anticholinergic activities of Botulinum Toxin Type B.
BretyliumBretylium may increase the hypotensive activities of Risperidone.
BrimonidineBrimonidine may increase the hypotensive activities of Risperidone.
BromocriptineThe therapeutic efficacy of Bromocriptine can be decreased when used in combination with Risperidone.
BumetanideThe risk or severity of adverse effects can be increased when Bumetanide is combined with Risperidone.
BuprenorphineRisperidone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Risperidone.
CabergolineThe risk or severity of adverse effects can be increased when Cabergoline is combined with Risperidone.
CanagliflozinThe therapeutic efficacy of Canagliflozin can be decreased when used in combination with Risperidone.
CandesartanCandesartan may increase the hypotensive activities of Risperidone.
CaptoprilCaptopril may increase the hypotensive activities of Risperidone.
CarbamazepineThe serum concentration of Risperidone can be decreased when it is combined with Carbamazepine.
CarteololCarteolol may increase the hypotensive activities of Risperidone.
CarvedilolCarvedilol may increase the hypotensive activities of Risperidone.
CathinoneRisperidone may decrease the stimulatory activities of Cathinone.
ChlorothiazideChlorothiazide may increase the hypotensive activities of Risperidone.
ChlorpropamideThe therapeutic efficacy of Chlorpropamide can be decreased when used in combination with Risperidone.
ChlorthalidoneChlorthalidone may increase the hypotensive activities of Risperidone.
CilazaprilCilazapril may increase the hypotensive activities of Risperidone.
Cimetropium BromideRisperidone may increase the anticholinergic activities of Cimetropium Bromide.
CitalopramThe risk or severity of adverse effects can be increased when Citalopram is combined with Risperidone.
ClevidipineClevidipine may increase the hypotensive activities of Risperidone.
ClomipramineThe risk or severity of adverse effects can be increased when Clomipramine is combined with Risperidone.
ClonidineClonidine may increase the hypotensive activities of Risperidone.
CobicistatThe serum concentration of Risperidone can be increased when it is combined with Cobicistat.
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Risperidone.
DapagliflozinDapagliflozin may increase the hypotensive activities of Risperidone.
DarunavirThe serum concentration of Risperidone can be increased when it is combined with Darunavir.
DesipramineThe risk or severity of adverse effects can be increased when Desipramine is combined with Risperidone.
DesvenlafaxineThe risk or severity of adverse effects can be increased when Desvenlafaxine is combined with Risperidone.
DexmedetomidineDexmedetomidine may increase the hypotensive activities of Risperidone.
DextroamphetamineRisperidone may decrease the stimulatory activities of Dextroamphetamine.
DextromethorphanThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Risperidone.
DiclofenamideDiclofenamide may increase the hypotensive activities of Risperidone.
DihydroergotamineThe risk or severity of adverse effects can be increased when Dihydroergotamine is combined with Risperidone.
DiltiazemDiltiazem may increase the hypotensive activities of Risperidone.
DinutuximabDinutuximab may increase the hypotensive activities of Risperidone.
DipyridamoleDipyridamole may increase the hypotensive activities of Risperidone.
DofetilideRisperidone may increase the QTc-prolonging activities of Dofetilide.
DonepezilDonepezil may increase the central neurotoxic activities of Risperidone.
DoxazosinDoxazosin may increase the hypotensive activities of Risperidone.
DoxepinThe risk or severity of adverse effects can be increased when Doxepin is combined with Risperidone.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Risperidone.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Risperidone.
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Risperidone.
DuloxetineThe risk or severity of adverse effects can be increased when Duloxetine is combined with Risperidone.
EletriptanThe risk or severity of adverse effects can be increased when Eletriptan is combined with Risperidone.
EluxadolineRisperidone may increase the activities of Eluxadoline.
EmpagliflozinEmpagliflozin may increase the hypotensive activities of Risperidone.
EnalaprilEnalapril may increase the hypotensive activities of Risperidone.
EnalaprilatEnalaprilat may increase the hypotensive activities of Risperidone.
EplerenoneEplerenone may increase the hypotensive activities of Risperidone.
EprosartanEprosartan may increase the hypotensive activities of Risperidone.
Ergoloid mesylateThe risk or severity of adverse effects can be increased when Ergoloid mesylate is combined with Risperidone.
ErgonovineThe risk or severity of adverse effects can be increased when Ergonovine is combined with Risperidone.
ErgotamineThe risk or severity of adverse effects can be increased when Ergotamine is combined with Risperidone.
EscitalopramThe risk or severity of adverse effects can be increased when Escitalopram is combined with Risperidone.
EsmololEsmolol may increase the hypotensive activities of Risperidone.
Etacrynic acidThe risk or severity of adverse effects can be increased when Ethacrynic acid is combined with Risperidone.
EthanolRisperidone may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
FelodipineFelodipine may increase the hypotensive activities of Risperidone.
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Risperidone.
FluoxetineThe risk or severity of adverse effects can be increased when Fluoxetine is combined with Risperidone.
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Risperidone.
FosinoprilFosinopril may increase the hypotensive activities of Risperidone.
FrovatriptanThe risk or severity of adverse effects can be increased when Frovatriptan is combined with Risperidone.
FurosemideThe risk or severity of adverse effects can be increased when Furosemide is combined with Risperidone.
GalantamineGalantamine may increase the central neurotoxic activities of Risperidone.
GliclazideThe therapeutic efficacy of Gliclazide can be decreased when used in combination with Risperidone.
GlimepirideThe therapeutic efficacy of Glimepiride can be decreased when used in combination with Risperidone.
GliquidoneThe therapeutic efficacy of Gliquidone can be decreased when used in combination with Risperidone.
Glucagon recombinantThe risk or severity of adverse effects can be increased when Risperidone is combined with Glucagon recombinant.
GlyburideThe therapeutic efficacy of Glyburide can be decreased when used in combination with Risperidone.
GoserelinRisperidone may increase the QTc-prolonging activities of Goserelin.
GuanfacineGuanfacine may increase the hypotensive activities of Risperidone.
HydralazineHydralazine may increase the hypotensive activities of Risperidone.
HydrochlorothiazideHydrochlorothiazide may increase the hypotensive activities of Risperidone.
HydrocodoneRisperidone may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Risperidone.
ImipramineThe risk or severity of adverse effects can be increased when Imipramine is combined with Risperidone.
IndapamideIndapamide may increase the hypotensive activities of Risperidone.
Insulin AspartThe therapeutic efficacy of Insulin Aspart can be decreased when used in combination with Risperidone.
Insulin DetemirThe therapeutic efficacy of Insulin Detemir can be decreased when used in combination with Risperidone.
Insulin GlargineThe therapeutic efficacy of Insulin Glargine can be decreased when used in combination with Risperidone.
Insulin GlulisineThe therapeutic efficacy of Insulin Glulisine can be decreased when used in combination with Risperidone.
Insulin HumanThe therapeutic efficacy of Insulin Regular can be decreased when used in combination with Risperidone.
Insulin LisproThe therapeutic efficacy of Insulin Lispro can be decreased when used in combination with Risperidone.
Ipratropium bromideIpratropium bromide may increase the anticholinergic activities of Risperidone.
IrbesartanIrbesartan may increase the hypotensive activities of Risperidone.
IsocarboxazidThe risk or severity of adverse effects can be increased when Isocarboxazid is combined with Risperidone.
IsosorbideIsosorbide may increase the hypotensive activities of Risperidone.
Isosorbide DinitrateIsosorbide Dinitrate may increase the hypotensive activities of Risperidone.
Isosorbide MononitrateIsosorbide Mononitrate may increase the hypotensive activities of Risperidone.
IsoxsuprineIsoxsuprine may increase the hypotensive activities of Risperidone.
IsradipineIsradipine may increase the hypotensive activities of Risperidone.
ItoprideThe therapeutic efficacy of Itopride can be decreased when used in combination with Risperidone.
LabetalolLabetalol may increase the hypotensive activities of Risperidone.
LeuprolideRisperidone may increase the QTc-prolonging activities of Leuprolide.
LevobunololLevobunolol may increase the hypotensive activities of Risperidone.
LevomilnacipranThe risk or severity of adverse effects can be increased when Levomilnacipran is combined with Risperidone.
LinagliptinThe therapeutic efficacy of Linagliptin can be decreased when used in combination with Risperidone.
LinezolidThe risk or severity of adverse effects can be increased when Linezolid is combined with Risperidone.
LisdexamfetamineRisperidone may decrease the stimulatory activities of Lisdexamfetamine.
LisinoprilLisinopril may increase the hypotensive activities of Risperidone.
LithiumLithium may increase the neurotoxic activities of Risperidone.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Risperidone.
LorcaserinThe risk or severity of adverse effects can be increased when Lorcaserin is combined with Risperidone.
LosartanLosartan may increase the hypotensive activities of Risperidone.
LumacaftorThe serum concentration of Risperidone can be decreased when it is combined with Lumacaftor.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Risperidone.
MannitolMannitol may increase the hypotensive activities of Risperidone.
MaprotilineThe risk or severity of adverse effects can be increased when Maprotiline is combined with Risperidone.
MecamylamineMecamylamine may increase the hypotensive activities of Risperidone.
MequitazineRisperidone may increase the arrhythmogenic activities of Mequitazine.
MetforminThe therapeutic efficacy of Metformin can be decreased when used in combination with Risperidone.
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Risperidone.
MethamphetamineRisperidone may decrease the stimulatory activities of Methamphetamine.
MethazolamideMethazolamide may increase the hypotensive activities of Risperidone.
MethotrimeprazineRisperidone may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
MethyclothiazideMethyclothiazide may increase the hypotensive activities of Risperidone.
MethyldopaMethyldopa may increase the hypotensive activities of Risperidone.
MethylphenidateThe risk or severity of adverse effects can be increased when Risperidone is combined with Methylphenidate.
MetipranololMetipranolol may increase the hypotensive activities of Risperidone.
MetoclopramideThe risk or severity of adverse effects can be increased when Metoclopramide is combined with Risperidone.
MetolazoneMetolazone may increase the hypotensive activities of Risperidone.
MetoprololMetoprolol may increase the hypotensive activities of Risperidone.
MetyrosineRisperidone may increase the sedative activities of Metyrosine.
MianserinMianserin may increase the anticholinergic activities of Risperidone.
MifepristoneMifepristone may increase the QTc-prolonging activities of Risperidone.
MilnacipranThe risk or severity of adverse effects can be increased when Milnacipran is combined with Risperidone.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Risperidone.
MinoxidilMinoxidil may increase the hypotensive activities of Risperidone.
MirabegronThe risk or severity of adverse effects can be increased when Risperidone is combined with Mirabegron.
MirtazapineRisperidone may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MoclobemideThe risk or severity of adverse effects can be increased when Moclobemide is combined with Risperidone.
MoexiprilMoexipril may increase the hypotensive activities of Risperidone.
MorphineThe risk or severity of adverse effects can be increased when Risperidone is combined with Morphine.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Risperidone.
NadololNadolol may increase the hypotensive activities of Risperidone.
NaratriptanThe risk or severity of adverse effects can be increased when Naratriptan is combined with Risperidone.
NebivololNebivolol may increase the hypotensive activities of Risperidone.
NefazodoneThe risk or severity of adverse effects can be increased when Nefazodone is combined with Risperidone.
NesiritideNesiritide may increase the hypotensive activities of Risperidone.
NicardipineNicardipine may increase the hypotensive activities of Risperidone.
NifedipineNifedipine may increase the hypotensive activities of Risperidone.
NimodipineNimodipine may increase the hypotensive activities of Risperidone.
NisoldipineNisoldipine may increase the hypotensive activities of Risperidone.
NitroglycerinNitroglycerin may increase the hypotensive activities of Risperidone.
NitroprussideNitroprusside may increase the hypotensive activities of Risperidone.
NortriptylineThe risk or severity of adverse effects can be increased when Nortriptyline is combined with Risperidone.
OlmesartanOlmesartan may increase the hypotensive activities of Risperidone.
OrphenadrineRisperidone may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
PaliperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Paliperidone.
PanobinostatThe serum concentration of Risperidone can be increased when it is combined with Panobinostat.
PapaverinePapaverine may increase the hypotensive activities of Risperidone.
ParaldehydeRisperidone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParoxetineThe metabolism of Risperidone can be decreased when combined with Paroxetine.
Peginterferon alfa-2bThe serum concentration of Risperidone can be decreased when it is combined with Peginterferon alfa-2b.
PenbutololPenbutolol may increase the hypotensive activities of Risperidone.
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Risperidone.
PerindoprilPerindopril may increase the hypotensive activities of Risperidone.
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Risperidone.
PhendimetrazineRisperidone may decrease the stimulatory activities of Phendimetrazine.
PhenelzineThe risk or severity of adverse effects can be increased when Phenelzine is combined with Risperidone.
PhentermineRisperidone may decrease the stimulatory activities of Phentermine.
PindololPindolol may increase the hypotensive activities of Risperidone.
Potassium ChlorideRisperidone may increase the ulcerogenic activities of Potassium Chloride.
PramlintidePramlintide may increase the anticholinergic activities of Risperidone.
PrazosinPrazosin may increase the hypotensive activities of Risperidone.
ProcarbazineThe risk or severity of adverse effects can be increased when Procarbazine is combined with Risperidone.
ProcyclidineThe risk or severity of adverse effects can be increased when Procyclidine is combined with Risperidone.
PromethazineThe risk or severity of adverse effects can be increased when Promethazine is combined with Risperidone.
PropranololPropranolol may increase the hypotensive activities of Risperidone.
ProtriptylineThe risk or severity of adverse effects can be increased when Protriptyline is combined with Risperidone.
QuinagolideThe therapeutic efficacy of Quinagolide can be decreased when used in combination with Risperidone.
QuinaprilQuinapril may increase the hypotensive activities of Risperidone.
RamiprilRamipril may increase the hypotensive activities of Risperidone.
RamosetronRisperidone may increase the activities of Ramosetron.
RanolazineThe serum concentration of Risperidone can be increased when it is combined with Ranolazine.
RasagilineThe risk or severity of adverse effects can be increased when Rasagiline is combined with Risperidone.
RepaglinideThe therapeutic efficacy of Repaglinide can be decreased when used in combination with Risperidone.
ReserpineReserpine may increase the hypotensive activities of Risperidone.
RiociguatRiociguat may increase the hypotensive activities of Risperidone.
RitonavirThe metabolism of Risperidone can be decreased when combined with Ritonavir.
RivastigmineRivastigmine may increase the central neurotoxic activities of Risperidone.
RizatriptanThe risk or severity of adverse effects can be increased when Rizatriptan is combined with Risperidone.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Risperidone.
SaquinavirThe serum concentration of Risperidone can be increased when it is combined with Saquinavir.
SaxagliptinThe therapeutic efficacy of Saxagliptin can be decreased when used in combination with Risperidone.
SecretinThe therapeutic efficacy of Secretin can be decreased when used in combination with Risperidone.
SelegilineThe risk or severity of adverse effects can be increased when Selegiline is combined with Risperidone.
SertralineThe metabolism of Risperidone can be decreased when combined with Sertraline.
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Risperidone.
SpironolactoneSpironolactone may increase the hypotensive activities of Risperidone.
SulpirideThe risk or severity of adverse effects can be increased when Risperidone is combined with Sulpiride.
SumatriptanThe risk or severity of adverse effects can be increased when Sumatriptan is combined with Risperidone.
SuvorexantRisperidone may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
TacrineThe therapeutic efficacy of Risperidone can be decreased when used in combination with Tacrine.
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Risperidone.
Tedizolid PhosphateThe risk or severity of adverse effects can be increased when Tedizolid Phosphate is combined with Risperidone.
TelmisartanTelmisartan may increase the hypotensive activities of Risperidone.
TerazosinTerazosin may increase the hypotensive activities of Risperidone.
TesmilifeneThe serum concentration of Risperidone can be decreased when it is combined with Tesmilifene.
TetrabenazineThe risk or severity of adverse effects can be increased when Tetrabenazine is combined with Risperidone.
ThalidomideRisperidone may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
TiclopidineThe metabolism of Risperidone can be decreased when combined with Ticlopidine.
TimololTimolol may increase the hypotensive activities of Risperidone.
TiotropiumRisperidone may increase the anticholinergic activities of Tiotropium.
TizanidineTizanidine may increase the hypotensive activities of Risperidone.
TolbutamideThe therapeutic efficacy of Tolbutamide can be decreased when used in combination with Risperidone.
TopiramateThe risk or severity of adverse effects can be increased when Risperidone is combined with Topiramate.
TorasemideThe risk or severity of adverse effects can be increased when Torasemide is combined with Risperidone.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Risperidone.
TrandolaprilTrandolapril may increase the hypotensive activities of Risperidone.
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Risperidone.
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Risperidone.
TriamtereneTriamterene may increase the hypotensive activities of Risperidone.
TrimipramineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Risperidone.
UmeclidiniumUmeclidinium may increase the anticholinergic activities of Risperidone.
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Risperidone.
ValsartanValsartan may increase the hypotensive activities of Risperidone.
VenlafaxineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Risperidone.
VerapamilThe serum concentration of Risperidone can be increased when it is combined with Verapamil.
VilazodoneThe metabolism of Risperidone can be decreased when combined with Vilazodone.
VildagliptinThe therapeutic efficacy of Vildagliptin can be decreased when used in combination with Risperidone.
VortioxetineThe metabolism of Risperidone can be decreased when combined with Vortioxetine.
ZolmitriptanThe risk or severity of adverse effects can be increased when Zolmitriptan is combined with Risperidone.
ZolpidemRisperidone may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Virus receptor activity
Specific Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates...
Gene Name:
HTR2A
Uniprot ID:
P28223
Molecular Weight:
52602.58 Da
References
  1. Fenton C, Scott LJ: Risperidone: a review of its use in the treatment of bipolar mania. CNS Drugs. 2005;19(5):429-44. [PubMed:15907153 ]
  2. Keks NA, Culhane C: Risperidone (Risperdal): clinical experience with a new antipsychosis drug. Expert Opin Investig Drugs. 1999 Apr;8(4):443-52. [PubMed:15992090 ]
  3. Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. [PubMed:11132243 ]
  4. Uchida S, Kato Y, Hirano K, Kagawa Y, Yamada S: Brain neurotransmitter receptor-binding characteristics in rats after oral administration of haloperidol, risperidone and olanzapine. Life Sci. 2007 Apr 3;80(17):1635-40. Epub 2007 Jan 27. [PubMed:17316700 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Potassium channel regulator activity
Specific Function:
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.
Gene Name:
DRD2
Uniprot ID:
P14416
Molecular Weight:
50618.91 Da
References
  1. Catafau AM, Corripio I, Perez V, Martin JC, Schotte A, Carrio I, Alvarez E: Dopamine D2 receptor occupancy by risperidone: implications for the timing and magnitude of clinical response. Psychiatry Res. 2006 Dec 1;148(2-3):175-83. Epub 2006 Oct 23. [PubMed:17059881 ]
  2. Fenton C, Scott LJ: Risperidone: a review of its use in the treatment of bipolar mania. CNS Drugs. 2005;19(5):429-44. [PubMed:15907153 ]
  3. Lane HY, Lee CC, Chang YC, Lu CT, Huang CH, Chang WH: Effects of dopamine D2 receptor Ser311Cys polymorphism and clinical factors on risperidone efficacy for positive and negative symptoms and social function. Int J Neuropsychopharmacol. 2004 Dec;7(4):461-70. Epub 2004 May 12. [PubMed:15140279 ]
  4. Naiker DV, Catts SV, Catts VS, Bedi KS, Bryan-Lluka LJ: Dose determination of haloperidol, risperidone and olanzapine using an in vivo dopamine D2-receptor occupancy method in the rat. Eur J Pharmacol. 2006 Jul 1;540(1-3):87-90. Epub 2006 May 11. [PubMed:16730699 ]
  5. Remington G, Mamo D, Labelle A, Reiss J, Shammi C, Mannaert E, Mann S, Kapur S: A PET study evaluating dopamine D2 receptor occupancy for long-acting injectable risperidone. Am J Psychiatry. 2006 Mar;163(3):396-401. [PubMed:16513859 ]
  6. Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. [PubMed:11132243 ]
  7. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
G-protein coupled amine receptor activity
Specific Function:
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
Gene Name:
DRD3
Uniprot ID:
P35462
Molecular Weight:
44224.335 Da
References
  1. Leysen JE, Janssen PM, Megens AA, Schotte A: Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity. J Clin Psychiatry. 1994 May;55 Suppl:5-12. [PubMed:7520908 ]
  2. Megens AA, Awouters FH, Schotte A, Meert TF, Dugovic C, Niemegeers CJ, Leysen JE: Survey on the pharmacodynamics of the new antipsychotic risperidone. Psychopharmacology (Berl). 1994 Feb;114(1):9-23. [PubMed:7531353 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Sh3 domain binding
Specific Function:
Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).
Gene Name:
DRD4
Uniprot ID:
P21917
Molecular Weight:
48359.86 Da
References
  1. Leysen JE, Janssen PM, Megens AA, Schotte A: Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity. J Clin Psychiatry. 1994 May;55 Suppl:5-12. [PubMed:7520908 ]
  2. Megens AA, Awouters FH, Schotte A, Meert TF, Dugovic C, Niemegeers CJ, Leysen JE: Survey on the pharmacodynamics of the new antipsychotic risperidone. Psychopharmacology (Berl). 1994 Feb;114(1):9-23. [PubMed:7531353 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Protein heterodimerization activity
Specific Function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
Gene Name:
ADRA1A
Uniprot ID:
P35348
Molecular Weight:
51486.005 Da
References
  1. Eltze M: In functional experiments, risperidone is selective, not for the B, but for the A subtype of alpha 1-adrenoceptors. Eur J Pharmacol. 1996 Jan 4;295(1):69-73. [PubMed:8925876 ]
  2. Fenton C, Scott LJ: Risperidone: a review of its use in the treatment of bipolar mania. CNS Drugs. 2005;19(5):429-44. [PubMed:15907153 ]
  3. Keks NA, Culhane C: Risperidone (Risperdal): clinical experience with a new antipsychosis drug. Expert Opin Investig Drugs. 1999 Apr;8(4):443-52. [PubMed:15992090 ]
  4. Nourian Z, Mow T, Muftic D, Burek S, Pedersen ML, Matz J, Mulvany MJ: Orthostatic hypotensive effect of antipsychotic drugs in Wistar rats by in vivo and in vitro studies of alpha1-adrenoceptor function. Psychopharmacology (Berl). 2008 Jul;199(1):15-27. doi: 10.1007/s00213-007-1064-9. Epub 2008 Jun 10. [PubMed:18542932 ]
  5. Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. [PubMed:11132243 ]
  6. Sleight AJ, Koek W, Bigg DC: Binding of antipsychotic drugs at alpha 1A- and alpha 1B-adrenoceptors: risperidone is selective for the alpha 1B-adrenoceptors. Eur J Pharmacol. 1993 Jul 20;238(2-3):407-10. [PubMed:7691623 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Protein heterodimerization activity
Specific Function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
Gene Name:
ADRA1B
Uniprot ID:
P35368
Molecular Weight:
56835.375 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Eltze M: In functional experiments, risperidone is selective, not for the B, but for the A subtype of alpha 1-adrenoceptors. Eur J Pharmacol. 1996 Jan 4;295(1):69-73. [PubMed:8925876 ]
  3. Fenton C, Scott LJ: Risperidone: a review of its use in the treatment of bipolar mania. CNS Drugs. 2005;19(5):429-44. [PubMed:15907153 ]
  4. Keks NA, Culhane C: Risperidone (Risperdal): clinical experience with a new antipsychosis drug. Expert Opin Investig Drugs. 1999 Apr;8(4):443-52. [PubMed:15992090 ]
  5. Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. [PubMed:11132243 ]
  6. Sleight AJ, Koek W, Bigg DC: Binding of antipsychotic drugs at alpha 1A- and alpha 1B-adrenoceptors: risperidone is selective for the alpha 1B-adrenoceptors. Eur J Pharmacol. 1993 Jul 20;238(2-3):407-10. [PubMed:7691623 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Serotonin receptor activity
Specific Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate c...
Gene Name:
HTR1D
Uniprot ID:
P28221
Molecular Weight:
41906.38 Da
References
  1. Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. [PubMed:11132243 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Histamine receptor activity
Specific Function:
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Gene Name:
HRH1
Uniprot ID:
P35367
Molecular Weight:
55783.61 Da
References
  1. Keks NA, Culhane C: Risperidone (Risperdal): clinical experience with a new antipsychosis drug. Expert Opin Investig Drugs. 1999 Apr;8(4):443-52. [PubMed:15992090 ]
  2. Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. [PubMed:11132243 ]
  3. Schreiber S, Backer MM, Weizman R, Pick CG: Augmentation of opioid induced antinociception by the atypical antipsychotic drug risperidone in mice. Neurosci Lett. 1997 May 30;228(1):25-8. [PubMed:9197279 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Thioesterase binding
Specific Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianser...
Gene Name:
ADRA2A
Uniprot ID:
P08913
Molecular Weight:
48956.275 Da
References
  1. Fenton C, Scott LJ: Risperidone: a review of its use in the treatment of bipolar mania. CNS Drugs. 2005;19(5):429-44. [PubMed:15907153 ]
  2. Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. [PubMed:11132243 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonistagonist
General Function:
Epinephrine binding
Specific Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phent...
Gene Name:
ADRA2B
Uniprot ID:
P18089
Molecular Weight:
49565.8 Da
References
  1. Fenton C, Scott LJ: Risperidone: a review of its use in the treatment of bipolar mania. CNS Drugs. 2005;19(5):429-44. [PubMed:15907153 ]
  2. Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. [PubMed:11132243 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Protein homodimerization activity
Specific Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
Gene Name:
ADRA2C
Uniprot ID:
P18825
Molecular Weight:
49521.585 Da
References
  1. Fenton C, Scott LJ: Risperidone: a review of its use in the treatment of bipolar mania. CNS Drugs. 2005;19(5):429-44. [PubMed:15907153 ]
  2. Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. [PubMed:11132243 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Serotonin receptor activity
Specific Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modul...
Gene Name:
HTR2C
Uniprot ID:
P28335
Molecular Weight:
51820.705 Da
References
  1. Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. [PubMed:11132243 ]
  2. Canton H, Verriele L, Millan MJ: Competitive antagonism of serotonin (5-HT)2C and 5-HT2A receptor-mediated phosphoinositide (PI) turnover by clozapine in the rat: a comparison to other antipsychotics. Neurosci Lett. 1994 Nov 7;181(1-2):65-8. [PubMed:7898773 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Serotonin receptor activity
Specific Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G pro...
Gene Name:
HTR1A
Uniprot ID:
P08908
Molecular Weight:
46106.335 Da
References
  1. Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. [PubMed:11132243 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
G-protein coupled amine receptor activity
Specific Function:
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
Gene Name:
DRD1
Uniprot ID:
P21728
Molecular Weight:
49292.765 Da
References
  1. Keks NA, Culhane C: Risperidone (Risperdal): clinical experience with a new antipsychosis drug. Expert Opin Investig Drugs. 1999 Apr;8(4):443-52. [PubMed:15992090 ]
  2. Leysen JE, Janssen PM, Megens AA, Schotte A: Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity. J Clin Psychiatry. 1994 May;55 Suppl:5-12. [PubMed:7520908 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Fang J, Bourin M, Baker GB: Metabolism of risperidone to 9-hydroxyrisperidone by human cytochromes P450 2D6 and 3A4. Naunyn Schmiedebergs Arch Pharmacol. 1999 Feb;359(2):147-51. [PubMed:10048600 ]
  2. Hendset M, Molden E, Refsum H, Hermann M: Impact of CYP2D6 genotype on steady-state serum concentrations of risperidone and 9-hydroxyrisperidone in patients using long-acting injectable risperidone. J Clin Psychopharmacol. 2009 Dec;29(6):537-41. doi: 10.1097/JCP.0b013e3181c17df0. [PubMed:19910717 ]
  3. Zhou SF: Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II. Clin Pharmacokinet. 2009;48(12):761-804. doi: 10.2165/11318070-000000000-00000. [PubMed:19902987 ]
  4. Zhou SF: Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I. Clin Pharmacokinet. 2009;48(11):689-723. doi: 10.2165/11318030-000000000-00000. [PubMed:19817501 ]
  5. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  6. Yasui-Furukori N, Hidestrand M, Spina E, Facciola G, Scordo MG, Tybring G: Different enantioselective 9-hydroxylation of risperidone by the two human CYP2D6 and CYP3A4 enzymes. Drug Metab Dispos. 2001 Oct;29(10):1263-8. [PubMed:11560868 ]
  7. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
  8. Source [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Fang J, Bourin M, Baker GB: Metabolism of risperidone to 9-hydroxyrisperidone by human cytochromes P450 2D6 and 3A4. Naunyn Schmiedebergs Arch Pharmacol. 1999 Feb;359(2):147-51. [PubMed:10048600 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Boulton DW, DeVane CL, Liston HL, Markowitz JS: In vitro P-glycoprotein affinity for atypical and conventional antipsychotics. Life Sci. 2002 May 31;71(2):163-9. [PubMed:12031686 ]
  2. Faassen F, Vogel G, Spanings H, Vromans H: Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. [PubMed:12954186 ]
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Drug created on June 13, 2005 07:24 / Updated on July 30, 2016 03:07