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Identification
NamePrimidone
Accession NumberDB00794  (APRD00549)
TypeSmall Molecule
GroupsApproved, Vet Approved
DescriptionAn antiepileptic agent related to the barbiturates; it is partly metabolized to phenobarbital in the body and owes some of its actions to this metabolite. Adverse effects are reported to be more frequent than with phenobarbital. (From Martindale, The Extra Pharmacopoeia, 30th ed, p309)
Structure
Thumb
Synonyms
5-Phenyl-5-ethyl-hexahydropyrimidine-4,6-dione
Desoxyphenobarbital
Mysoline
Primaclone
Primidon
Primidona
Primidone
Primidonum
External Identifiers
  • Rö 101
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Mysolinetablet50 mg/1oralValeant Pharmaceuticals North America2009-06-24Not applicableUs
Mysolinetablet250 mg/1oralValeant Pharmaceuticals North America2009-06-24Not applicableUs
Mysoline 250mg Tabtablet250 mgoralElan Pharmaceuticals Inc1994-12-312004-08-05Canada
Mysoline Pediatric Chewable Tablets 125mgtablet125 mgoralElan Pharmaceuticals Inc1994-12-312004-08-05Canada
Mysoline Tab 125mgtablet125 mgoralAyerst Laboratories1963-12-311996-09-10Canada
Mysoline Tab 250mgtablet250 mgoralAyerst Laboratories1965-12-311997-08-15Canada
Primidonetablet250 mgoralAa Pharma Inc1977-12-31Not applicableCanada
Primidonetablet125 mgoralAa Pharma Inc1977-12-31Not applicableCanada
Primidone 125 Tabtablet125 mgoralPro Doc Limitee1982-12-311999-08-12Canada
Primidone 250 Tabtablet250 mgoralPro Doc Limitee1982-12-311999-08-12Canada
Sertan Tab 125mgtablet125 mgoralPharmascience Inc1983-12-312005-05-09Canada
Sertan Tab 250mgtablet250 mgoralPharmascience Inc1983-12-312005-05-09Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Primidonetablet250 mg/1oralPhysicians Total Care, Inc.2009-07-27Not applicableUs
Primidonetablet50 mg/1oralQualitest Pharmaceuticals2005-02-24Not applicableUs
Primidonetablet250 mg/1oralMarlex Pharmaceuticals Inc2015-05-01Not applicableUs
Primidonetablet50 mg/1oralGlobal Pharmaceuticals2008-02-12Not applicableUs
Primidonetablet250 mg/1oralAmerican Health Packaging2007-06-14Not applicableUs
Primidonetablet50 mg/1oralCardinal Health2001-05-242016-02-25Us
Primidonetablet250 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1978-12-01Not applicableUs
Primidonetablet50 mg/1oralSTAT Rx USA LLC2001-05-24Not applicableUs
Primidonetablet250 mg/1oralLannett Company, Inc.1978-12-01Not applicableUs
Primidonetablet50 mg/1oralPhysicians Total Care, Inc.2009-01-29Not applicableUs
Primidonetablet250 mg/1oralQualitest Pharmaceuticals2005-02-24Not applicableUs
Primidonetablet50 mg/1oralMarlex Pharmaceuticals Inc2015-05-01Not applicableUs
Primidonetablet250 mg/1oralGlobal Pharmaceuticals2008-02-12Not applicableUs
Primidonetablet50 mg/1oralMc Kesson Contract Packaging2011-12-27Not applicableUs
Primidonetablet50 mg/1oralAmneal Pharmaceuticals2009-12-24Not applicableUs
Primidonetablet250 mg/1oralMajor Pharmaceuticals2005-04-07Not applicableUs
Primidonetablet50 mg/1oralAv Pak2011-05-19Not applicableUs
Primidonetablet50 mg/1oralLannett Company, Inc.2001-05-24Not applicableUs
Primidonetablet250 mg/1oralDr. Reddy's Laboratories Ltd2008-10-03Not applicableUs
Primidonetablet250 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-07-01Not applicableUs
Primidonetablet50 mg/1oralAv Kare, Inc.2008-04-24Not applicableUs
Primidonetablet50 mg/1oralWest ward Pharmaceutical Corp2006-07-01Not applicableUs
Primidonetablet50 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2005-02-24Not applicableUs
Primidonetablet250 mg/1oralAmneal Pharmaceuticals2009-12-24Not applicableUs
Primidonetablet50 mg/1oralMajor Pharmaceuticals2005-04-07Not applicableUs
Primidonetablet250 mg/1oralAv Pak2011-05-19Not applicableUs
Primidonetablet250 mg/1oralWatson Laboratories, Inc.2010-06-19Not applicableUs
Primidonetablet50 mg/1oralDr. Reddy's Laboratories Ltd2008-10-03Not applicableUs
Primidonetablet50 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2001-05-24Not applicableUs
Primidonetablet250 mg/1oralAv Kare, Inc.2008-04-24Not applicableUs
Primidonetablet250 mg/1oralWest ward Pharmaceutical Corp2006-07-01Not applicableUs
Primidonetablet50 mg/1oralAmerican Health Packaging2007-06-14Not applicableUs
Primidonetablet250 mg/1oralMajor Pharmaceuticals2009-12-24Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
LiskantinDesitin
MizodinUnia
MylepsinumNot Available
PridonaPsicofarma
PrimidApsen
PrysolineRekah
SertanAlkaloida
Brand mixturesNot Available
SaltsNot Available
Categories
UNII13AFD7670Q
CAS number125-33-7
WeightAverage: 218.2518
Monoisotopic: 218.105527702
Chemical FormulaC12H14N2O2
InChI KeyInChIKey=DQMZLTXERSFNPB-UHFFFAOYSA-N
InChI
InChI=1S/C12H14N2O2/c1-2-12(9-6-4-3-5-7-9)10(15)13-8-14-11(12)16/h3-7H,2,8H2,1H3,(H,13,15)(H,14,16)
IUPAC Name
5-ethyl-5-phenyl-1,3-diazinane-4,6-dione
SMILES
CCC1(C(=O)NCNC1=O)C1=CC=CC=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as hydropyrimidines. These are compounds containing a hydrogenated pyrimidine ring (i.e containing less than the maximum bumber of double bonds.).
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassDiazines
Sub ClassPyrimidines and pyrimidine derivatives
Direct ParentHydropyrimidines
Alternative Parents
Substituents
  • Benzenoid
  • 1,3-diazinane
  • Monocyclic benzene moiety
  • Secondary carboxylic acid amide
  • Lactam
  • Carboxamide group
  • Azacycle
  • Carboxylic acid derivative
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor the treatment of epilepsy
PharmacodynamicsPrimidone is a barbiturate with anticonvulsant properties. Primidone, either alone or used concomitantly with other anticonvulsants, is indicated in the control of grand mal, psychomotor, and focal epileptic seizures. It may control grand mal seizures refractory to other anticonvulsant therapy. Primidone raises electro- or chemoshock seizure thresholds or alters seizure patterns in experimental animals. Primidone per se has anticonvulsant activity as do its two metabolites, phenobarbital and phenylethylmalonamide (PEMA). In addition to its anticonvulsant activity, Primidone potentiates that of phenobarbital in experimental animals.
Mechanism of actionPrimidone is a GABA receptor agonist. The mechanism of Primidone's antiepileptic action is not known.
Related Articles
Absorption90 to 100%
Volume of distributionNot Available
Protein binding70%
Metabolism

Hepatic

SubstrateEnzymesProduct
Primidone
PhenobarbitalDetails
Route of eliminationNot Available
Half life3-23 hours
ClearanceNot Available
ToxicitySymptoms of an overdose typically include sluggishness, incoordination, difficulty in thinking, slowness of speech, faulty judgment, drowsiness or coma, shallow breathing, staggering, and in severe cases coma and death.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9907
Blood Brain Barrier+0.9642
Caco-2 permeable-0.5593
P-glycoprotein substrateSubstrate0.5222
P-glycoprotein inhibitor INon-inhibitor0.536
P-glycoprotein inhibitor IINon-inhibitor0.9048
Renal organic cation transporterNon-inhibitor0.8298
CYP450 2C9 substrateNon-substrate0.7961
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateNon-substrate0.6863
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.924
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorNon-inhibitor0.8309
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8682
Ames testAMES toxic0.9107
CarcinogenicityNon-carcinogens0.7814
BiodegradationNot ready biodegradable0.982
Rat acute toxicity2.1941 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9912
hERG inhibition (predictor II)Non-inhibitor0.8735
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Xcel pharmaceuticals
  • Valeant pharmaceuticals international
  • Amneal pharmaceutical
  • Dr reddys laboratories ltd
  • Impax laboratories inc
  • Lannett co inc
  • Mutual pharmaceutical co inc
  • Vintage pharmaceuticals inc
  • Watson laboratories inc
  • West ward pharmaceutical corp
Packagers
Dosage forms
FormRouteStrength
Tabletoral125 mg
Tabletoral250 mg
Tabletoral250 mg/1
Tabletoral50 mg/1
Prices
Unit descriptionCostUnit
Primidone powder10.56USD g
Mysoline 250 mg tablet6.52USD tablet
Mysoline 50 mg tablet1.26USD tablet
Primidone 250 mg tablet1.02USD tablet
Primidone 50 mg tablet0.51USD tablet
Apo-Primidone 250 mg Tablet0.09USD tablet
Apo-Primidone 125 mg Tablet0.06USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point281.5 °CPhysProp
water solubility500 mg/L (at 22 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP0.91HANSCH,C ET AL. (1995)
logS-2.64ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility1.04 mg/mLALOGPS
logP0.62ALOGPS
logP1.12ChemAxon
logS-2.3ALOGPS
pKa (Strongest Acidic)11.5ChemAxon
pKa (Strongest Basic)-6.2ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area58.2 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity59.04 m3·mol-1ChemAxon
Polarizability22.44 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (9.01 KB)
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis ReferenceNot Available
General References
  1. Murphy K, Delanty N: Primary Generalized Epilepsies. Curr Treat Options Neurol. 2000 Nov;2(6):527-542. [PubMed:11096777 ]
  2. Kagitani-Shimono K, Imai K, Okamoto N, Ono J, Okada S: Unverricht-Lundborg disease with cystatin B gene abnormalities. Pediatr Neurol. 2002 Jan;26(1):55-60. [PubMed:11814737 ]
  3. Brown GM, Stone GH, Rathbone MP: Primidone and rapid cycling affective disorders. Lancet. 1993 Oct 9;342(8876):925. [PubMed:8105181 ]
  4. Schaffer LC, Schaffer CB, Caretto J: The use of primidone in the treatment of refractory bipolar disorder. Ann Clin Psychiatry. 1999 Jun;11(2):61-6. [PubMed:10440522 ]
  5. Young MC, Hughes IA: Loss of therapeutic control in congenital adrenal hyperplasia due to interaction between dexamethasone and primidone. Acta Paediatr Scand. 1991 Jan;80(1):120-4. [PubMed:2028784 ]
External Links
ATC CodesN03AA03
AHFS Codes
  • 28:12.04
PDB EntriesNot Available
FDA labelDownload (108 KB)
MSDSDownload (65.5 KB)
Interactions
Drug Interactions
Drug
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be decreased when it is combined with Primidone.
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Primidone.
AbirateroneThe serum concentration of Abiraterone can be decreased when it is combined with Primidone.
AbirateroneThe metabolism of Primidone can be decreased when combined with Abiraterone.
AcebutololPrimidone may increase the hypotensive activities of Acebutolol.
AceclofenacThe metabolism of Aceclofenac can be increased when combined with Primidone.
AcenocoumarolThe metabolism of Acenocoumarol can be increased when combined with Primidone.
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Primidone.
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Primidone.
AcetaminophenThe metabolism of Acetaminophen can be increased when combined with Primidone.
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Primidone.
AcetazolamidePrimidone may increase the hypotensive activities of Acetazolamide.
Acetylsalicylic acidThe metabolism of Acetylsalicylic acid can be increased when combined with Primidone.
AdinazolamThe metabolism of Adinazolam can be increased when combined with Primidone.
adipiplonThe risk or severity of adverse effects can be increased when adipiplon is combined with Primidone.
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Primidone.
AlbendazoleThe metabolism of Albendazole can be increased when combined with Primidone.
AlclometasoneThe serum concentration of Alclometasone can be decreased when it is combined with Primidone.
AldesleukinPrimidone may increase the hypotensive activities of Aldesleukin.
AldosteroneThe serum concentration of Aldosterone can be decreased when it is combined with Primidone.
AlfaxaloneThe risk or severity of adverse effects can be increased when Alfaxalone is combined with Primidone.
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Primidone.
AlfuzosinThe metabolism of Alfuzosin can be increased when combined with Primidone.
AliskirenPrimidone may increase the hypotensive activities of Aliskiren.
AllylestrenolThe metabolism of Allylestrenol can be increased when combined with Primidone.
AlmotriptanThe metabolism of Almotriptan can be increased when combined with Primidone.
AlogliptinThe metabolism of Alogliptin can be increased when combined with Primidone.
AlosetronThe metabolism of Alosetron can be increased when combined with Primidone.
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Primidone.
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Primidone.
AlprenololThe serum concentration of Alprenolol can be decreased when it is combined with Primidone.
AmbrisentanThe metabolism of Ambrisentan can be increased when combined with Primidone.
AmbroxolThe metabolism of Ambroxol can be increased when combined with Primidone.
AmcinonideThe serum concentration of Amcinonide can be decreased when it is combined with Primidone.
AmiloridePrimidone may increase the hypotensive activities of Amiloride.
AmineptineThe metabolism of Amineptine can be increased when combined with Primidone.
AminophenazoneThe metabolism of Aminophenazone can be increased when combined with Primidone.
AminophyllineThe serum concentration of Aminophylline can be decreased when it is combined with Primidone.
AmiodaroneThe metabolism of Amiodarone can be increased when combined with Primidone.
AmisulprideThe risk or severity of adverse effects can be increased when Amisulpride is combined with Primidone.
AmitriptylineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Primidone.
AmlodipinePrimidone may increase the hypotensive activities of Amlodipine.
AmobarbitalThe risk or severity of adverse effects can be increased when Primidone is combined with Amobarbital.
AmodiaquineThe metabolism of Amodiaquine can be increased when combined with Primidone.
AmoxapineThe risk or severity of adverse effects can be increased when Primidone is combined with Amoxapine.
AmperozideThe risk or severity of adverse effects can be increased when Amperozide is combined with Primidone.
AmprenavirThe metabolism of Amprenavir can be increased when combined with Primidone.
AmrinoneThe metabolism of Amrinone can be increased when combined with Primidone.
Amyl NitritePrimidone may increase the hypotensive activities of Amyl Nitrite.
AnagrelideThe metabolism of Anagrelide can be increased when combined with Primidone.
AntipyrineThe metabolism of Antipyrine can be increased when combined with Primidone.
ApixabanThe serum concentration of Apixaban can be decreased when it is combined with Primidone.
ApraclonidinePrimidone may increase the hypotensive activities of Apraclonidine.
ApremilastThe serum concentration of Apremilast can be decreased when it is combined with Primidone.
AprepitantThe metabolism of Aprepitant can be increased when combined with Primidone.
Arachidonic AcidThe metabolism of Arachidonic Acid can be increased when combined with Primidone.
ArformoterolThe metabolism of Arformoterol can be increased when combined with Primidone.
ArgatrobanThe metabolism of Argatroban can be increased when combined with Primidone.
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Primidone.
ArmodafinilThe metabolism of Primidone can be decreased when combined with Armodafinil.
ArotinololThe serum concentration of Arotinolol can be decreased when it is combined with Primidone.
ArtemetherThe serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with Primidone resulting in a loss in efficacy.
ArticaineThe risk or severity of adverse effects can be increased when Articaine is combined with Primidone.
ASA404The metabolism of ASA404 can be increased when combined with Primidone.
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Primidone.
AstemizoleThe metabolism of Astemizole can be increased when combined with Primidone.
AtazanavirThe metabolism of Atazanavir can be increased when combined with Primidone.
AtenololPrimidone may increase the hypotensive activities of Atenolol.
AtorvastatinThe metabolism of Atorvastatin can be increased when combined with Primidone.
AV650The metabolism of AV650 can be increased when combined with Primidone.
AvanafilThe metabolism of Avanafil can be increased when combined with Primidone.
AxitinibThe serum concentration of Axitinib can be decreased when it is combined with Primidone.
AzaperoneThe risk or severity of adverse effects can be increased when Azaperone is combined with Primidone.
AzelastinePrimidone may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Primidone.
AzelnidipineThe metabolism of Azelnidipine can be increased when combined with Primidone.
Azilsartan medoxomilPrimidone may increase the hypotensive activities of Azilsartan medoxomil.
AzimilideThe metabolism of Azimilide can be increased when combined with Primidone.
AzithromycinThe metabolism of Azithromycin can be increased when combined with Primidone.
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Primidone.
BanoxantroneThe metabolism of Banoxantrone can be increased when combined with Primidone.
BarbitalThe risk or severity of adverse effects can be increased when Primidone is combined with Barbital.
BarnidipineThe metabolism of Barnidipine can be increased when combined with Primidone.
BazedoxifeneThe serum concentration of Bazedoxifene can be decreased when it is combined with Primidone.
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be decreased when it is combined with Primidone.
BedaquilineThe serum concentration of Bedaquiline can be decreased when it is combined with Primidone.
BefunololThe serum concentration of Befunolol can be decreased when it is combined with Primidone.
BenazeprilPrimidone may increase the hypotensive activities of Benazepril.
BendamustineThe serum concentration of Bendamustine can be decreased when it is combined with Primidone.
BendroflumethiazidePrimidone may increase the orthostatic hypotensive activities of Bendroflumethiazide.
BenidipineThe metabolism of Benidipine can be increased when combined with Primidone.
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Primidone.
BenzphetamineThe metabolism of Benzphetamine can be increased when combined with Primidone.
Benzyl alcoholThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Primidone.
BepridilThe metabolism of Bepridil can be increased when combined with Primidone.
BeraprostThe metabolism of Beraprost can be increased when combined with Primidone.
BetamethasoneThe serum concentration of Betamethasone can be decreased when it is combined with Primidone.
BetaxololPrimidone may increase the hypotensive activities of Betaxolol.
BevantololThe serum concentration of Bevantolol can be decreased when it is combined with Primidone.
BexaroteneThe metabolism of Bexarotene can be increased when combined with Primidone.
BezafibrateThe metabolism of Bezafibrate can be increased when combined with Primidone.
BicalutamideThe metabolism of Bicalutamide can be increased when combined with Primidone.
BisoprololPrimidone may increase the hypotensive activities of Bisoprolol.
BoceprevirThe serum concentration of Boceprevir can be decreased when it is combined with Primidone.
BopindololThe serum concentration of Bopindolol can be decreased when it is combined with Primidone.
BortezomibThe serum concentration of Bortezomib can be decreased when it is combined with Primidone.
BortezomibThe metabolism of Primidone can be decreased when combined with Bortezomib.
BosentanThe metabolism of Bosentan can be increased when combined with Primidone.
BosutinibThe serum concentration of Bosutinib can be decreased when it is combined with Primidone.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be decreased when it is combined with Primidone.
BretyliumPrimidone may increase the hypotensive activities of Bretylium.
BrexpiprazoleThe risk or severity of adverse effects can be increased when Primidone is combined with Brexpiprazole.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Primidone.
BrimonidinePrimidone may increase the hypotensive activities of Brimonidine.
BrinzolamideThe risk or severity of adverse effects can be increased when Brinzolamide is combined with Primidone.
BrinzolamideThe metabolism of Brinzolamide can be increased when combined with Primidone.
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Primidone.
BromocriptineThe metabolism of Bromocriptine can be increased when combined with Primidone.
BrompheniramineThe risk or severity of adverse effects can be increased when Primidone is combined with Brompheniramine.
BrotizolamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Primidone.
BudesonideThe serum concentration of Budesonide can be decreased when it is combined with Primidone.
BufuralolThe serum concentration of Bufuralol can be decreased when it is combined with Primidone.
BumetanidePrimidone may increase the hypotensive activities of Bumetanide.
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Primidone.
BupranololThe serum concentration of Bupranolol can be decreased when it is combined with Primidone.
BuprenorphineThe risk or severity of adverse effects can be increased when Buprenorphine is combined with Primidone.
BupropionThe metabolism of Bupropion can be increased when combined with Primidone.
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Primidone.
BusulfanThe metabolism of Busulfan can be increased when combined with Primidone.
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Primidone.
ButacaineThe risk or severity of adverse effects can be increased when Butacaine is combined with Primidone.
ButalbitalThe risk or severity of adverse effects can be increased when Butalbital is combined with Primidone.
ButambenThe risk or severity of adverse effects can be increased when Butamben is combined with Primidone.
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Primidone.
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Primidone.
CabazitaxelThe metabolism of Cabazitaxel can be increased when combined with Primidone.
CabergolineThe metabolism of Cabergoline can be increased when combined with Primidone.
CabozantinibThe serum concentration of Cabozantinib can be decreased when it is combined with Primidone.
CaffeineThe metabolism of Caffeine can be increased when combined with Primidone.
CalcitriolThe metabolism of Calcitriol can be increased when combined with Primidone.
CanagliflozinPrimidone may increase the hypotensive activities of Canagliflozin.
CandesartanPrimidone may increase the hypotensive activities of Candesartan.
CannabidiolThe serum concentration of Cannabidiol can be decreased when it is combined with Primidone.
CaptoprilPrimidone may increase the hypotensive activities of Captopril.
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Primidone.
CarbinoxamineThe risk or severity of adverse effects can be increased when Carbinoxamine is combined with Primidone.
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Primidone.
CariprazineThe metabolism of Cariprazine can be increased when combined with Primidone.
CarisoprodolThe risk or severity of adverse effects can be increased when Carisoprodol is combined with Primidone.
CarmustineThe metabolism of Carmustine can be increased when combined with Primidone.
CarteololPrimidone may increase the hypotensive activities of Carteolol.
CarvedilolPrimidone may increase the hypotensive activities of Carvedilol.
CelecoxibThe metabolism of Celecoxib can be increased when combined with Primidone.
CeliprololThe serum concentration of Celiprolol can be decreased when it is combined with Primidone.
CephalexinThe metabolism of Cephalexin can be increased when combined with Primidone.
CeritinibThe serum concentration of Ceritinib can be decreased when it is combined with Primidone.
CerivastatinThe metabolism of Cerivastatin can be increased when combined with Primidone.
CetirizineThe risk or severity of adverse effects can be increased when Cetirizine is combined with Primidone.
CevimelineThe metabolism of Cevimeline can be increased when combined with Primidone.
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be increased when combined with Primidone.
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Primidone.
ChloramphenicolThe metabolism of Primidone can be decreased when combined with Chloramphenicol.
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Primidone.
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Primidone.
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Primidone.
ChloroquineThe metabolism of Chloroquine can be increased when combined with Primidone.
ChlorothiazidePrimidone may increase the orthostatic hypotensive activities of Chlorothiazide.
ChlorphenamineThe risk or severity of adverse effects can be increased when Primidone is combined with Chlorphenamine.
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Primidone.
ChlorpropamideThe metabolism of Chlorpropamide can be increased when combined with Primidone.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Primidone.
ChlorthalidonePrimidone may increase the orthostatic hypotensive activities of Chlorthalidone.
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Primidone.
CholecalciferolThe metabolism of Cholecalciferol can be increased when combined with Primidone.
CiclesonideThe serum concentration of Ciclesonide can be decreased when it is combined with Primidone.
CilazaprilPrimidone may increase the hypotensive activities of Cilazapril.
CilnidipineThe metabolism of Cilnidipine can be increased when combined with Primidone.
CilostazolThe metabolism of Cilostazol can be increased when combined with Primidone.
CimetidineThe metabolism of Primidone can be decreased when combined with Cimetidine.
CinacalcetThe metabolism of Cinacalcet can be increased when combined with Primidone.
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Primidone.
CinnarizineThe metabolism of Cinnarizine can be increased when combined with Primidone.
CisaprideThe metabolism of Cisapride can be increased when combined with Primidone.
CitalopramThe risk or severity of adverse effects can be increased when Primidone is combined with Citalopram.
CitalopramThe metabolism of Primidone can be decreased when combined with Citalopram.
ClarithromycinThe serum concentration of the active metabolites of Clarithromycin can be increased when Clarithromycin is used in combination with Primidone.
ClemastineThe risk or severity of adverse effects can be increased when Clemastine is combined with Primidone.
ClenbuterolThe metabolism of Clenbuterol can be increased when combined with Primidone.
ClevidipinePrimidone may increase the hypotensive activities of Clevidipine.
ClidiniumThe risk or severity of adverse effects can be increased when Clidinium is combined with Primidone.
ClindamycinThe metabolism of Clindamycin can be increased when combined with Primidone.
ClobazamThe risk or severity of adverse effects can be increased when Clobazam is combined with Primidone.
Clobetasol propionateThe serum concentration of Clobetasol propionate can be decreased when it is combined with Primidone.
ClocortoloneThe serum concentration of Clocortolone can be decreased when it is combined with Primidone.
ClofazimineThe metabolism of Clofazimine can be increased when combined with Primidone.
ClofibrateThe metabolism of Clofibrate can be increased when combined with Primidone.
clomethiazoleThe risk or severity of adverse effects can be increased when clomethiazole is combined with Primidone.
ClomipramineThe risk or severity of adverse effects can be increased when Primidone is combined with Clomipramine.
ClonazepamThe risk or severity of adverse effects can be increased when Primidone is combined with Clonazepam.
ClonidinePrimidone may increase the hypotensive activities of Clonidine.
ClonidineThe risk or severity of adverse effects can be increased when Clonidine is combined with Primidone.
ClopidogrelThe metabolism of Clopidogrel can be increased when combined with Primidone.
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Primidone.
ClotiazepamThe metabolism of Clotiazepam can be increased when combined with Primidone.
ClotrimazoleThe metabolism of Primidone can be decreased when combined with Clotrimazole.
ClozapineThe serum concentration of Clozapine can be decreased when it is combined with Primidone.
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Primidone.
CobicistatThe serum concentration of Cobicistat can be decreased when it is combined with Primidone.
CobimetinibThe serum concentration of Cobimetinib can be decreased when it is combined with Primidone.
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Primidone.
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Primidone.
ColchicineThe metabolism of Colchicine can be increased when combined with Primidone.
ConivaptanThe metabolism of Conivaptan can be increased when combined with Primidone.
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be increased when combined with Primidone.
Cortisone acetateThe serum concentration of Cortisone acetate can be decreased when it is combined with Primidone.
CosyntropinCosyntropin may increase the hepatotoxic activities of Primidone.
CrizotinibThe serum concentration of Crizotinib can be decreased when it is combined with Primidone.
CyclizineThe risk or severity of adverse effects can be increased when Primidone is combined with Cyclizine.
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Primidone.
CyclophosphamideThe metabolism of Cyclophosphamide can be increased when combined with Primidone.
CyclosporineThe metabolism of Cyclosporine can be increased when combined with Primidone.
CyproheptadineThe risk or severity of adverse effects can be increased when Cyproheptadine is combined with Primidone.
CytarabineThe metabolism of Cytarabine can be increased when combined with Primidone.
DabrafenibThe serum concentration of Primidone can be decreased when it is combined with Dabrafenib.
DabrafenibThe metabolism of Dabrafenib can be increased when combined with Primidone.
DacarbazineThe metabolism of Dacarbazine can be increased when combined with Primidone.
DaclatasvirThe serum concentration of Daclatasvir can be decreased when it is combined with Primidone.
DantroleneThe risk or severity of adverse effects can be increased when Primidone is combined with Dantrolene.
DapagliflozinPrimidone may increase the hypotensive activities of Dapagliflozin.
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Primidone.
DapoxetineThe risk or severity of adverse effects can be increased when Primidone is combined with Dapoxetine.
DapsoneThe metabolism of Dapsone can be increased when combined with Primidone.
DarifenacinThe metabolism of Darifenacin can be increased when combined with Primidone.
DarodipineThe metabolism of Darodipine can be increased when combined with Primidone.
DarunavirThe metabolism of Darunavir can be increased when combined with Primidone.
DasabuvirThe metabolism of Dasabuvir can be increased when combined with Primidone.
DasatinibThe serum concentration of Dasatinib can be decreased when it is combined with Primidone.
DaunorubicinThe metabolism of Daunorubicin can be increased when combined with Primidone.
DehydroepiandrosteroneThe serum concentration of Dehydroepiandrosterone can be decreased when it is combined with Primidone.
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be decreased when it is combined with Primidone.
DelavirdineThe metabolism of Delavirdine can be increased when combined with Primidone.
deramciclaneThe risk or severity of adverse effects can be increased when deramciclane is combined with Primidone.
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Primidone.
DesipramineThe risk or severity of adverse effects can be increased when Primidone is combined with Desipramine.
DesloratadineThe risk or severity of adverse effects can be increased when Primidone is combined with Desloratadine.
DesoximetasoneThe serum concentration of Desoximetasone can be decreased when it is combined with Primidone.
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be decreased when it is combined with Primidone.
DesvenlafaxineThe metabolism of Desvenlafaxine can be increased when combined with Primidone.
DetomidineThe risk or severity of adverse effects can be increased when Detomidine is combined with Primidone.
DexamethasoneThe serum concentration of Dexamethasone can be decreased when it is combined with Primidone.
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be decreased when it is combined with Primidone.
DexbrompheniramineThe risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Primidone.
DexfenfluramineThe metabolism of Dexfenfluramine can be increased when combined with Primidone.
DexmedetomidinePrimidone may increase the hypotensive activities of Dexmedetomidine.
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Primidone.
DexmethylphenidateThe serum concentration of the active metabolites of Primidone can be increased when Primidone is used in combination with Dexmethylphenidate.
DextromethorphanThe metabolism of Dextromethorphan can be increased when combined with Primidone.
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Primidone.
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Primidone.
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Primidone.
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Primidone.
DiclofenacThe serum concentration of Diclofenac can be decreased when it is combined with Primidone.
DiclofenamideThe risk or severity of adverse effects can be increased when Diclofenamide is combined with Primidone.
DiclofenamidePrimidone may increase the hypotensive activities of Diclofenamide.
DicoumarolThe metabolism of Dicoumarol can be increased when combined with Primidone.
DienogestThe serum concentration of Dienogest can be decreased when it is combined with Primidone.
DifenoxinThe risk or severity of adverse effects can be increased when Primidone is combined with Difenoxin.
DiflorasoneThe serum concentration of Diflorasone can be decreased when it is combined with Primidone.
DifluocortoloneThe serum concentration of Difluocortolone can be decreased when it is combined with Primidone.
DifluprednateThe serum concentration of Difluprednate can be decreased when it is combined with Primidone.
DigitoxinThe metabolism of Digitoxin can be increased when combined with Primidone.
DigoxinThe metabolism of Digoxin can be increased when combined with Primidone.
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Primidone.
DihydroergotamineThe metabolism of Dihydroergotamine can be increased when combined with Primidone.
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Primidone.
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Primidone.
DiltiazemPrimidone may increase the hypotensive activities of Diltiazem.
DimenhydrinateThe risk or severity of adverse effects can be increased when Primidone is combined with Dimenhydrinate.
DinoprostoneThe metabolism of Dinoprostone can be increased when combined with Primidone.
DinutuximabPrimidone may increase the hypotensive activities of Dinutuximab.
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Primidone.
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Primidone.
DipyridamolePrimidone may increase the hypotensive activities of Dipyridamole.
DisopyramideThe metabolism of Disopyramide can be increased when combined with Primidone.
DisulfiramThe metabolism of Disulfiram can be increased when combined with Primidone.
DocetaxelThe metabolism of Docetaxel can be increased when combined with Primidone.
DofetilideThe metabolism of Dofetilide can be increased when combined with Primidone.
DolasetronThe metabolism of Dolasetron can be increased when combined with Primidone.
DolutegravirThe serum concentration of Dolutegravir can be decreased when it is combined with Primidone.
DomperidoneThe metabolism of Domperidone can be increased when combined with Primidone.
DonepezilThe metabolism of Donepezil can be increased when combined with Primidone.
DopamineThe metabolism of Dopamine can be increased when combined with Primidone.
DoramectinThe risk or severity of adverse effects can be increased when Doramectin is combined with Primidone.
DorzolamideThe risk or severity of adverse effects can be increased when Dorzolamide is combined with Primidone.
DorzolamideThe metabolism of Dorzolamide can be increased when combined with Primidone.
DosulepinThe metabolism of Dosulepin can be increased when combined with Primidone.
DotarizineThe metabolism of Dotarizine can be increased when combined with Primidone.
DoxazosinPrimidone may increase the hypotensive activities of Doxazosin.
DoxepinThe risk or severity of adverse effects can be increased when Primidone is combined with Doxepin.
DoxorubicinThe serum concentration of Doxorubicin can be decreased when it is combined with Primidone.
DoxycyclineThe serum concentration of Doxycycline can be decreased when it is combined with Primidone.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Primidone.
DoxylamineThe risk or severity of adverse effects can be increased when Primidone is combined with Doxylamine.
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Primidone.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Primidone.
DronabinolThe serum concentration of Dronabinol can be decreased when it is combined with Primidone.
DronedaroneThe serum concentration of Dronedarone can be decreased when it is combined with Primidone.
DroperidolThe risk or severity of adverse effects can be increased when Droperidol is combined with Primidone.
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Primidone.
DuloxetineThe metabolism of Duloxetine can be increased when combined with Primidone.
DutasterideThe metabolism of Dutasteride can be increased when combined with Primidone.
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Primidone.
DyphyllineThe serum concentration of Dyphylline can be decreased when it is combined with Primidone.
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Primidone.
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when ECGONINE METHYL ESTER is combined with Primidone.
EfavirenzThe risk or severity of adverse effects can be increased when Efavirenz is combined with Primidone.
EfonidipineThe metabolism of Efonidipine can be increased when combined with Primidone.
EletriptanThe metabolism of Eletriptan can be increased when combined with Primidone.
EliglustatThe serum concentration of Eliglustat can be decreased when it is combined with Primidone.
EltrombopagThe metabolism of Eltrombopag can be increased when combined with Primidone.
ElvitegravirThe metabolism of Elvitegravir can be increased when combined with Primidone.
EmpagliflozinPrimidone may increase the hypotensive activities of Empagliflozin.
EnalaprilPrimidone may increase the hypotensive activities of Enalapril.
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Primidone.
EntacaponeThe risk or severity of adverse effects can be increased when Entacapone is combined with Primidone.
EnzalutamideThe serum concentration of Enzalutamide can be decreased when it is combined with Primidone.
EperisoneThe metabolism of Eperisone can be increased when combined with Primidone.
EpinastineThe metabolism of Epinastine can be increased when combined with Primidone.
EplerenonePrimidone may increase the hypotensive activities of Eplerenone.
EpoprostenolThe metabolism of Epoprostenol can be increased when combined with Primidone.
EprosartanPrimidone may increase the hypotensive activities of Eprosartan.
EquileninThe serum concentration of Equilenin can be decreased when it is combined with Primidone.
EquilinThe serum concentration of Equilin can be decreased when it is combined with Primidone.
ErgocalciferolThe metabolism of Ergocalciferol can be increased when combined with Primidone.
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be increased when combined with Primidone.
ErgonovineThe metabolism of Ergonovine can be increased when combined with Primidone.
ErgotamineThe metabolism of Ergotamine can be increased when combined with Primidone.
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Primidone.
ErythromycinThe metabolism of Erythromycin can be increased when combined with Primidone.
EscitalopramThe risk or severity of adverse effects can be increased when Primidone is combined with Escitalopram.
Eslicarbazepine acetateThe serum concentration of Eslicarbazepine acetate can be decreased when it is combined with Primidone.
Eslicarbazepine acetateThe metabolism of Primidone can be decreased when combined with Eslicarbazepine acetate.
EsmirtazapineThe metabolism of Esmirtazapine can be increased when combined with Primidone.
EsmololPrimidone may increase the hypotensive activities of Esmolol.
EsomeprazoleThe metabolism of Esomeprazole can be increased when combined with Primidone.
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Primidone.
EstradiolThe metabolism of Estradiol can be increased when combined with Primidone.
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be increased when combined with Primidone.
EstramustineThe metabolism of Estramustine can be increased when combined with Primidone.
EstroneThe serum concentration of Estrone can be decreased when it is combined with Primidone.
Estrone sulfateThe metabolism of Estrone sulfate can be increased when combined with Primidone.
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Primidone.
Etacrynic acidPrimidone may increase the hypotensive activities of Etacrynic acid.
EthanolPrimidone may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Primidone.
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Primidone.
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be increased when combined with Primidone.
EthosuximideThe risk or severity of adverse effects can be increased when Ethosuximide is combined with Primidone.
EthotoinThe risk or severity of adverse effects can be increased when Ethotoin is combined with Primidone.
EthoxzolamideThe risk or severity of adverse effects can be increased when Ethoxzolamide is combined with Primidone.
Ethyl biscoumacetateThe metabolism of Ethyl biscoumacetate can be increased when combined with Primidone.
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Primidone.
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Primidone.
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Primidone.
EtidocaineThe risk or severity of adverse effects can be increased when Etidocaine is combined with Primidone.
EtifoxineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Primidone.
EtizolamThe risk or severity of adverse effects can be increased when Etizolam is combined with Primidone.
EtodolacThe metabolism of Etodolac can be increased when combined with Primidone.
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Primidone.
EtonogestrelThe metabolism of Etonogestrel can be increased when combined with Primidone.
EtoperidoneThe risk or severity of adverse effects can be increased when Primidone is combined with Etoperidone.
EtoposideThe serum concentration of Etoposide can be decreased when it is combined with Primidone.
EtoricoxibThe metabolism of Etoricoxib can be increased when combined with Primidone.
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Primidone.
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Primidone.
EtravirineThe metabolism of Primidone can be decreased when combined with Etravirine.
EverolimusThe serum concentration of Everolimus can be decreased when it is combined with Primidone.
ExemestaneThe serum concentration of Exemestane can be decreased when it is combined with Primidone.
EzogabineThe risk or severity of adverse effects can be increased when Primidone is combined with Ezogabine.
FamciclovirThe metabolism of Famciclovir can be increased when combined with Primidone.
FelbamateThe serum concentration of Primidone can be increased when it is combined with Felbamate.
FelbamateThe risk or severity of adverse effects can be increased when Primidone is combined with Felbamate.
FelodipinePrimidone may increase the hypotensive activities of Felodipine.
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Primidone.
FendilineThe metabolism of Fendiline can be increased when combined with Primidone.
FenfluramineThe risk or severity of adverse effects can be increased when Primidone is combined with Fenfluramine.
FenofibrateThe metabolism of Fenofibrate can be increased when combined with Primidone.
FentanylThe serum concentration of Fentanyl can be decreased when it is combined with Primidone.
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Primidone.
FesoterodineThe metabolism of Fesoterodine can be increased when combined with Primidone.
FexofenadineThe risk or severity of adverse effects can be increased when Primidone is combined with Fexofenadine.
FinasterideThe metabolism of Finasteride can be increased when combined with Primidone.
FingolimodThe metabolism of Fingolimod can be increased when combined with Primidone.
FlibanserinThe serum concentration of Flibanserin can be decreased when it is combined with Primidone.
FlibanserinThe risk or severity of adverse effects can be increased when Flibanserin is combined with Primidone.
FluconazoleThe metabolism of Primidone can be decreased when combined with Fluconazole.
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Primidone.
FludrocortisoneThe serum concentration of Fludrocortisone can be decreased when it is combined with Primidone.
FlumethasoneThe serum concentration of Flumethasone can be decreased when it is combined with Primidone.
FlunarizineThe metabolism of Flunarizine can be increased when combined with Primidone.
FlunarizineThe risk or severity of adverse effects can be increased when Flunarizine is combined with Primidone.
FlunisolideThe serum concentration of Flunisolide can be decreased when it is combined with Primidone.
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Primidone.
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be decreased when it is combined with Primidone.
FluocinonideThe serum concentration of Fluocinonide can be decreased when it is combined with Primidone.
FluocortoloneThe serum concentration of Fluocortolone can be decreased when it is combined with Primidone.
FluorometholoneThe serum concentration of Fluorometholone can be decreased when it is combined with Primidone.
FluorouracilThe metabolism of Fluorouracil can be increased when combined with Primidone.
FluoxetineThe risk or severity of adverse effects can be increased when Primidone is combined with Fluoxetine.
FluoxetineThe metabolism of Primidone can be decreased when combined with Fluoxetine.
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Primidone.
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Primidone.
FluprednideneThe serum concentration of Fluprednidene can be decreased when it is combined with Primidone.
FluprednisoloneThe serum concentration of Fluprednisolone can be decreased when it is combined with Primidone.
FlurandrenolideThe serum concentration of Flurandrenolide can be decreased when it is combined with Primidone.
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Primidone.
FlurbiprofenThe metabolism of Flurbiprofen can be increased when combined with Primidone.
FluspirileneThe risk or severity of adverse effects can be increased when Fluspirilene is combined with Primidone.
FlutamideThe metabolism of Flutamide can be increased when combined with Primidone.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be decreased when it is combined with Primidone.
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Primidone.
FluvastatinThe metabolism of Fluvastatin can be increased when combined with Primidone.
FluvoxamineThe risk or severity of adverse effects can be increased when Primidone is combined with Fluvoxamine.
Folic AcidThe serum concentration of Primidone can be decreased when it is combined with Folic Acid.
FormoterolThe metabolism of Formoterol can be increased when combined with Primidone.
FosamprenavirThe metabolism of Fosamprenavir can be increased when combined with Primidone.
FosinoprilPrimidone may increase the hypotensive activities of Fosinopril.
FosphenytoinThe metabolism of Primidone can be increased when combined with Fosphenytoin.
FosphenytoinThe risk or severity of adverse effects can be increased when Primidone is combined with Fosphenytoin.
FospropofolThe risk or severity of adverse effects can be increased when Fospropofol is combined with Primidone.
FrovatriptanThe metabolism of Frovatriptan can be increased when combined with Primidone.
FulvestrantThe metabolism of Fulvestrant can be increased when combined with Primidone.
FurosemidePrimidone may increase the hypotensive activities of Furosemide.
GabapentinThe metabolism of Gabapentin can be increased when combined with Primidone.
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Primidone.
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Primidone is combined with gabapentin enacarbil.
GalantamineThe metabolism of Galantamine can be increased when combined with Primidone.
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Primidone.
GavestinelThe metabolism of Gavestinel can be increased when combined with Primidone.
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Primidone.
GemfibrozilThe metabolism of Gemfibrozil can be increased when combined with Primidone.
GenisteinThe metabolism of Genistein can be increased when combined with Primidone.
GliclazideThe metabolism of Gliclazide can be increased when combined with Primidone.
GlimepirideThe metabolism of Glimepiride can be increased when combined with Primidone.
GlipizideThe metabolism of Glipizide can be increased when combined with Primidone.
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Primidone.
GlyburideThe metabolism of Glyburide can be increased when combined with Primidone.
GranisetronThe metabolism of Granisetron can be increased when combined with Primidone.
GrepafloxacinThe metabolism of Grepafloxacin can be increased when combined with Primidone.
GriseofulvinThe serum concentration of Griseofulvin can be decreased when it is combined with Primidone.
GuanabenzThe metabolism of Guanabenz can be increased when combined with Primidone.
GuanfacinePrimidone may increase the hypotensive activities of Guanfacine.
GuanfacineThe risk or severity of adverse effects can be increased when Guanfacine is combined with Primidone.
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Primidone.
HalofantrineThe metabolism of Halofantrine can be increased when combined with Primidone.
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Primidone.
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Primidone.
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Primidone.
HesperetinThe metabolism of Hesperetin can be increased when combined with Primidone.
HexobarbitalThe risk or severity of adverse effects can be increased when Primidone is combined with Hexobarbital.
Histamine PhosphateThe metabolism of Histamine Phosphate can be increased when combined with Primidone.
HydralazinePrimidone may increase the hypotensive activities of Hydralazine.
HydrochlorothiazidePrimidone may increase the orthostatic hypotensive activities of Hydrochlorothiazide.
HydrocodoneThe serum concentration of Hydrocodone can be decreased when it is combined with Primidone.
HydrocodoneThe risk or severity of adverse effects can be increased when Hydrocodone is combined with Primidone.
HydrocortisoneThe serum concentration of Hydrocortisone can be decreased when it is combined with Primidone.
HydroflumethiazidePrimidone may increase the orthostatic hypotensive activities of Hydroflumethiazide.
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Primidone.
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be increased when combined with Primidone.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Primidone.
HydroxyzineThe risk or severity of adverse effects can be increased when Primidone is combined with Hydroxyzine.
IbrutinibThe serum concentration of Ibrutinib can be decreased when it is combined with Primidone.
IbuprofenThe metabolism of Ibuprofen can be increased when combined with Primidone.
IdarubicinThe metabolism of Idarubicin can be increased when combined with Primidone.
IdelalisibThe serum concentration of Idelalisib can be decreased when it is combined with Primidone.
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be increased when Ifosfamide is used in combination with Primidone.
IloperidoneThe risk or severity of adverse effects can be increased when Primidone is combined with Iloperidone.
ImatinibThe serum concentration of Imatinib can be decreased when it is combined with Primidone.
ImipramineThe risk or severity of adverse effects can be increased when Imipramine is combined with Primidone.
ImiquimodThe metabolism of Imiquimod can be increased when combined with Primidone.
IndacaterolThe metabolism of Indacaterol can be increased when combined with Primidone.
IndalpineThe risk or severity of adverse effects can be increased when Primidone is combined with Indalpine.
IndapamidePrimidone may increase the orthostatic hypotensive activities of Indapamide.
IndenololThe serum concentration of Indenolol can be decreased when it is combined with Primidone.
IndinavirThe metabolism of Indinavir can be increased when combined with Primidone.
indisulamThe metabolism of indisulam can be increased when combined with Primidone.
IndomethacinThe metabolism of Indomethacin can be increased when combined with Primidone.
Ipratropium bromideThe metabolism of Ipratropium bromide can be increased when combined with Primidone.
IrbesartanPrimidone may increase the hypotensive activities of Irbesartan.
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be reduced when Irinotecan is used in combination with Primidone resulting in a loss in efficacy.
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Primidone resulting in a loss in efficacy.
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Primidone.
IsoniazidThe metabolism of Primidone can be decreased when combined with Isoniazid.
Isosorbide DinitratePrimidone may increase the hypotensive activities of Isosorbide Dinitrate.
Isosorbide MononitratePrimidone may increase the hypotensive activities of Isosorbide Mononitrate.
IsoxsuprinePrimidone may increase the hypotensive activities of Isoxsuprine.
IsradipinePrimidone may increase the hypotensive activities of Isradipine.
ItraconazoleThe serum concentration of Itraconazole can be decreased when it is combined with Primidone.
IvabradineThe serum concentration of Ivabradine can be decreased when it is combined with Primidone.
IvacaftorThe serum concentration of Ivacaftor can be decreased when it is combined with Primidone.
IvermectinThe metabolism of Ivermectin can be increased when combined with Primidone.
IxabepiloneThe serum concentration of Ixabepilone can be decreased when it is combined with Primidone.
IxazomibThe serum concentration of Ixazomib can be decreased when it is combined with Primidone.
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Primidone.
KetazolamThe risk or severity of adverse effects can be increased when Ketazolam is combined with Primidone.
KetobemidoneThe risk or severity of adverse effects can be increased when Ketobemidone is combined with Primidone.
KetoconazoleThe metabolism of Ketoconazole can be increased when combined with Primidone.
KetoprofenThe metabolism of Ketoprofen can be increased when combined with Primidone.
LabetalolPrimidone may increase the hypotensive activities of Labetalol.
LacidipineThe metabolism of Lacidipine can be increased when combined with Primidone.
LamotrigineThe metabolism of Lamotrigine can be increased when combined with Primidone.
LamotrigineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Primidone.
LansoprazoleThe metabolism of Lansoprazole can be increased when combined with Primidone.
LapatinibThe serum concentration of Lapatinib can be decreased when it is combined with Primidone.
LaquinimodThe metabolism of Laquinimod can be increased when combined with Primidone.
LeflunomideThe metabolism of Leflunomide can be increased when combined with Primidone.
LenvatinibThe metabolism of Lenvatinib can be increased when combined with Primidone.
LercanidipineThe metabolism of Lercanidipine can be increased when combined with Primidone.
LesinuradThe metabolism of Lesinurad can be increased when combined with Primidone.
LetrozoleThe metabolism of Letrozole can be increased when combined with Primidone.
LevetiracetamThe risk or severity of adverse effects can be increased when Primidone is combined with Levetiracetam.
LevobunololPrimidone may increase the hypotensive activities of Levobunolol.
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Primidone.
LevocabastineThe risk or severity of adverse effects can be increased when Primidone is combined with Levocabastine.
LevocetirizineThe risk or severity of adverse effects can be increased when Primidone is combined with Levocetirizine.
LevodopaThe risk or severity of adverse effects can be increased when Primidone is combined with Levodopa.
LevomefolateThe serum concentration of the active metabolites of Primidone can be reduced when Primidone is used in combination with Levomefolate resulting in a loss in efficacy.
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Primidone.
LevomilnacipranThe risk or severity of adverse effects can be increased when Primidone is combined with Levomilnacipran.
LevonorgestrelThe metabolism of Levonorgestrel can be increased when combined with Primidone.
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Primidone.
LevothyroxineThe metabolism of Levothyroxine can be increased when combined with Primidone.
LicofeloneThe metabolism of Licofelone can be increased when combined with Primidone.
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Primidone.
LinagliptinThe serum concentration of Linagliptin can be decreased when it is combined with Primidone.
LisinoprilPrimidone may increase the hypotensive activities of Lisinopril.
LisurideThe metabolism of Lisuride can be increased when combined with Primidone.
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Primidone.
LofentanilThe risk or severity of adverse effects can be increased when Lofentanil is combined with Primidone.
LomefloxacinThe metabolism of Lomefloxacin can be increased when combined with Primidone.
LomitapideThe metabolism of Lomitapide can be increased when combined with Primidone.
LoperamideThe metabolism of Loperamide can be increased when combined with Primidone.
LopinavirThe metabolism of Lopinavir can be increased when combined with Primidone.
LoratadineThe risk or severity of adverse effects can be increased when Loratadine is combined with Primidone.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Primidone.
LorcaserinThe metabolism of Lorcaserin can be increased when combined with Primidone.
LornoxicamThe metabolism of Lornoxicam can be increased when combined with Primidone.
LosartanPrimidone may increase the hypotensive activities of Losartan.
LovastatinThe metabolism of Lovastatin can be increased when combined with Primidone.
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Primidone.
Lu AA21004The risk or severity of adverse effects can be increased when Primidone is combined with Lu AA21004.
LuliconazoleThe serum concentration of Primidone can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Primidone can be decreased when it is combined with Lumacaftor.
LumefantrineThe serum concentration of Lumefantrine can be decreased when it is combined with Primidone.
LumiracoxibThe metabolism of Lumiracoxib can be increased when combined with Primidone.
LurasidoneThe serum concentration of Lurasidone can be decreased when it is combined with Primidone.
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with Primidone.
MacitentanThe serum concentration of Macitentan can be decreased when it is combined with Primidone.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Primidone.
Magnesium SulfateThe metabolism of Magnesium Sulfate can be increased when combined with Primidone.
MalathionThe metabolism of Malathion can be increased when combined with Primidone.
ManidipineThe metabolism of Manidipine can be increased when combined with Primidone.
MannitolPrimidone may increase the hypotensive activities of Mannitol.
MaprotilineThe risk or severity of adverse effects can be increased when Primidone is combined with Maprotiline.
MaravirocThe serum concentration of Maraviroc can be decreased when it is combined with Primidone.
MebendazoleThe metabolism of Mebendazole can be increased when combined with Primidone.
MecamylaminePrimidone may increase the hypotensive activities of Mecamylamine.
MeclizineThe risk or severity of adverse effects can be increased when Meclizine is combined with Primidone.
MedetomidineThe risk or severity of adverse effects can be increased when Medetomidine is combined with Primidone.
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be increased when combined with Primidone.
MedrysoneThe serum concentration of Medrysone can be decreased when it is combined with Primidone.
Mefenamic acidThe metabolism of Mefenamic acid can be increased when combined with Primidone.
MefloquineThe therapeutic efficacy of Primidone can be decreased when used in combination with Mefloquine.
MefloquineThe metabolism of Mefloquine can be increased when combined with Primidone.
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Primidone.
MelengestrolThe serum concentration of Melengestrol can be decreased when it is combined with Primidone.
MeloxicamThe metabolism of Meloxicam can be increased when combined with Primidone.
MelperoneThe risk or severity of adverse effects can be increased when Melperone is combined with Primidone.
MenadioneThe metabolism of Menadione can be increased when combined with Primidone.
MephenytoinThe metabolism of Mephenytoin can be increased when combined with Primidone.
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Primidone.
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Primidone.
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Primidone.
MestranolThe metabolism of Mestranol can be increased when combined with Primidone.
MetaxaloneThe risk or severity of adverse effects can be increased when Metaxalone is combined with Primidone.
MethadoneThe serum concentration of Methadone can be decreased when it is combined with Primidone.
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Primidone.
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Primidone.
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Primidone.
MethaqualoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Primidone.
MethazolamideThe risk or severity of adverse effects can be increased when Methazolamide is combined with Primidone.
MethazolamidePrimidone may increase the hypotensive activities of Methazolamide.
MethocarbamolThe risk or severity of adverse effects can be increased when Methocarbamol is combined with Primidone.
MethohexitalThe risk or severity of adverse effects can be increased when Primidone is combined with Methohexital.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Methotrimeprazine is combined with Primidone.
MethoxsalenThe metabolism of Methoxsalen can be increased when combined with Primidone.
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Primidone.
MethsuximideThe risk or severity of adverse effects can be increased when Primidone is combined with Methsuximide.
MethyclothiazidePrimidone may increase the orthostatic hypotensive activities of Methyclothiazide.
MethyldopaPrimidone may increase the hypotensive activities of Methyldopa.
MethylphenidateThe serum concentration of the active metabolites of Primidone can be increased when Primidone is used in combination with Methylphenidate.
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Primidone is combined with Methylphenobarbital.
MethylprednisoloneThe serum concentration of Methylprednisolone can be decreased when it is combined with Primidone.
MethyltestosteroneThe metabolism of Methyltestosterone can be increased when combined with Primidone.
MetipranololPrimidone may increase the hypotensive activities of Metipranolol.
MetolazonePrimidone may increase the orthostatic hypotensive activities of Metolazone.
MetoprololPrimidone may increase the hypotensive activities of Metoprolol.
MetronidazoleThe serum concentration of Metronidazole can be decreased when it is combined with Primidone.
MetyrosinePrimidone may increase the sedative activities of Metyrosine.
MexiletineThe metabolism of Mexiletine can be increased when combined with Primidone.
MianserinMianserin may increase the central nervous system depressant (CNS depressant) activities of Primidone.
MianserinThe metabolism of Mianserin can be increased when combined with Primidone.
MibefradilThe metabolism of Mibefradil can be increased when combined with Primidone.
MiconazoleThe metabolism of Miconazole can be increased when combined with Primidone.
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Primidone.
MifepristoneThe serum concentration of Mifepristone can be decreased when it is combined with Primidone.
MilnacipranThe risk or severity of adverse effects can be increased when Primidone is combined with Milnacipran.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Primidone.
MinoxidilPrimidone may increase the hypotensive activities of Minoxidil.
MirabegronThe metabolism of Mirabegron can be increased when combined with Primidone.
MirtazapinePrimidone may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MirtazapineThe risk or severity of adverse effects can be increased when Mirtazapine is combined with Primidone.
MoclobemideThe metabolism of Primidone can be decreased when combined with Moclobemide.
ModafinilThe metabolism of Modafinil can be increased when combined with Primidone.
MoexiprilPrimidone may increase the hypotensive activities of Moexipril.
MolindoneThe risk or severity of adverse effects can be increased when Molindone is combined with Primidone.
MometasoneThe serum concentration of Mometasone can be decreased when it is combined with Primidone.
MontelukastThe metabolism of Montelukast can be increased when combined with Primidone.
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Primidone.
muraglitazarThe metabolism of muraglitazar can be increased when combined with Primidone.
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be increased when combined with Primidone.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Primidone.
NabiloneThe risk or severity of adverse effects can be increased when Primidone is combined with Nabilone.
NabumetoneThe metabolism of Nabumetone can be increased when combined with Primidone.
NadololPrimidone may increase the hypotensive activities of Nadolol.
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Primidone.
NaloxegolThe serum concentration of Naloxegol can be decreased when it is combined with Primidone.
NaloxoneThe metabolism of Naloxone can be increased when combined with Primidone.
NaproxenThe metabolism of Naproxen can be increased when combined with Primidone.
NateglinideThe metabolism of Nateglinide can be increased when combined with Primidone.
NebivololPrimidone may increase the hypotensive activities of Nebivolol.
NefazodoneThe metabolism of Nefazodone can be increased when combined with Primidone.
NelfinavirThe metabolism of Nelfinavir can be increased when combined with Primidone.
NesiritidePrimidone may increase the hypotensive activities of Nesiritide.
NetupitantThe serum concentration of Netupitant can be decreased when it is combined with Primidone.
NevirapineThe metabolism of Nevirapine can be increased when combined with Primidone.
NicardipinePrimidone may increase the hypotensive activities of Nicardipine.
NicardipineThe metabolism of Primidone can be decreased when combined with Nicardipine.
NiclosamideThe metabolism of Niclosamide can be increased when combined with Primidone.
NicotineThe metabolism of Nicotine can be increased when combined with Primidone.
NifedipineThe serum concentration of Nifedipine can be decreased when it is combined with Primidone.
NiguldipineThe metabolism of Niguldipine can be increased when combined with Primidone.
NilotinibThe serum concentration of Nilotinib can be decreased when it is combined with Primidone.
NiludipineThe metabolism of Niludipine can be increased when combined with Primidone.
NilvadipineThe metabolism of Nilvadipine can be increased when combined with Primidone.
NimesulideThe metabolism of Nimesulide can be increased when combined with Primidone.
NimodipineThe serum concentration of Nimodipine can be decreased when it is combined with Primidone.
NintedanibThe serum concentration of Nintedanib can be decreased when it is combined with Primidone.
NisoldipineThe serum concentration of Nisoldipine can be decreased when it is combined with Primidone.
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Primidone.
NitrendipineThe metabolism of Nitrendipine can be increased when combined with Primidone.
Nitric OxideThe metabolism of Nitric Oxide can be increased when combined with Primidone.
NitroglycerinPrimidone may increase the hypotensive activities of Nitroglycerin.
NitroprussidePrimidone may increase the hypotensive activities of Nitroprusside.
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Primidone.
NorethisteroneThe metabolism of Norethisterone can be increased when combined with Primidone.
NorgestrelThe metabolism of Norgestrel can be increased when combined with Primidone.
NormethadoneThe risk or severity of adverse effects can be increased when Normethadone is combined with Primidone.
NortriptylineThe risk or severity of adverse effects can be increased when Nortriptyline is combined with Primidone.
OlanzapineThe risk or severity of adverse effects can be increased when Primidone is combined with Olanzapine.
OlaparibThe serum concentration of Olaparib can be decreased when it is combined with Primidone.
OlmesartanPrimidone may increase the hypotensive activities of Olmesartan.
OlodaterolThe metabolism of Olodaterol can be increased when combined with Primidone.
OlopatadineThe risk or severity of adverse effects can be increased when Olopatadine is combined with Primidone.
OmbitasvirThe metabolism of Ombitasvir can be increased when combined with Primidone.
OmeprazoleThe metabolism of Omeprazole can be increased when combined with Primidone.
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Primidone.
OpiumThe risk or severity of adverse effects can be increased when Opium is combined with Primidone.
OrlistatThe serum concentration of Primidone can be decreased when it is combined with Orlistat.
OrphenadrinePrimidone may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OrphenadrineThe risk or severity of adverse effects can be increased when Orphenadrine is combined with Primidone.
OsanetantThe risk or severity of adverse effects can be increased when Osanetant is combined with Primidone.
OsimertinibThe serum concentration of Osimertinib can be decreased when it is combined with Primidone.
OspemifeneThe metabolism of Ospemifene can be increased when combined with Primidone.
OxaliplatinThe metabolism of Oxaliplatin can be increased when combined with Primidone.
OxaprozinThe metabolism of Oxaprozin can be increased when combined with Primidone.
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Primidone.
OxprenololThe serum concentration of Oxprenolol can be decreased when it is combined with Primidone.
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Primidone.
OxtriphyllineThe metabolism of Oxtriphylline can be increased when combined with Primidone.
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Primidone.
OxybutyninThe metabolism of Oxybutynin can be increased when combined with Primidone.
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Primidone.
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Primidone.
PaclitaxelThe metabolism of Paclitaxel can be increased when combined with Primidone.
PalbociclibThe serum concentration of Palbociclib can be decreased when it is combined with Primidone.
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Primidone.
PalonosetronThe metabolism of Palonosetron can be increased when combined with Primidone.
PanobinostatThe serum concentration of Panobinostat can be decreased when it is combined with Primidone.
PantoprazoleThe metabolism of Pantoprazole can be increased when combined with Primidone.
PapaverinePrimidone may increase the hypotensive activities of Papaverine.
ParaldehydePrimidone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParaldehydeThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Primidone.
ParamethadioneThe metabolism of Paramethadione can be increased when combined with Primidone.
ParamethasoneThe serum concentration of Paramethasone can be decreased when it is combined with Primidone.
ParecoxibThe metabolism of Parecoxib can be increased when combined with Primidone.
ParicalcitolThe metabolism of Paricalcitol can be increased when combined with Primidone.
ParitaprevirThe metabolism of Paritaprevir can be increased when combined with Primidone.
ParoxetineThe risk or severity of adverse effects can be increased when Primidone is combined with Paroxetine.
PazopanibThe serum concentration of Pazopanib can be decreased when it is combined with Primidone.
PenbutololPrimidone may increase the hypotensive activities of Penbutolol.
PentamidineThe metabolism of Pentamidine can be increased when combined with Primidone.
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Primidone.
PentobarbitalThe risk or severity of adverse effects can be increased when Primidone is combined with Pentobarbital.
PentoxifyllineThe metabolism of Pentoxifylline can be increased when combined with Primidone.
PerampanelThe serum concentration of Perampanel can be decreased when it is combined with Primidone.
PerampanelThe risk or severity of adverse effects can be increased when Perampanel is combined with Primidone.
PergolideThe metabolism of Pergolide can be increased when combined with Primidone.
PerhexilineThe metabolism of Perhexiline can be increased when combined with Primidone.
PerindoprilPrimidone may increase the hypotensive activities of Perindopril.
PermethrinThe metabolism of Permethrin can be increased when combined with Primidone.
PerospironeThe risk or severity of adverse effects can be increased when Perospirone is combined with Primidone.
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Primidone.
PethidinePrimidone may increase the central nervous system depressant (CNS depressant) activities of Pethidine.
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Primidone.
PhenacetinThe metabolism of Phenacetin can be increased when combined with Primidone.
PhenindioneThe metabolism of Phenindione can be increased when combined with Primidone.
PhenobarbitalThe risk or severity of adverse effects can be increased when Primidone is combined with Phenobarbital.
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be increased when combined with Primidone.
PhenoxyethanolThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Primidone.
PhenprocoumonThe metabolism of Phenprocoumon can be increased when combined with Primidone.
PhenylbutazoneThe metabolism of Phenylbutazone can be increased when combined with Primidone.
PhenytoinThe metabolism of Primidone can be increased when combined with Phenytoin.
PhenytoinThe risk or severity of adverse effects can be increased when Primidone is combined with Phenytoin.
PilocarpineThe metabolism of Pilocarpine can be increased when combined with Primidone.
PimecrolimusThe metabolism of Pimecrolimus can be increased when combined with Primidone.
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Primidone.
PinacidilThe metabolism of Pinacidil can be increased when combined with Primidone.
PinaveriumThe metabolism of Pinaverium can be increased when combined with Primidone.
PindololPrimidone may increase the hypotensive activities of Pindolol.
PioglitazoneThe metabolism of Pioglitazone can be increased when combined with Primidone.
PipamperoneThe risk or severity of adverse effects can be increased when Pipamperone is combined with Primidone.
PipotiazineThe risk or severity of adverse effects can be increased when Primidone is combined with Pipotiazine.
PirfenidoneThe serum concentration of Pirfenidone can be decreased when it is combined with Primidone.
PiroxicamThe metabolism of Piroxicam can be increased when combined with Primidone.
PitavastatinThe metabolism of Pitavastatin can be increased when combined with Primidone.
PizotifenThe risk or severity of adverse effects can be increased when Primidone is combined with Pizotifen.
PodofiloxThe metabolism of Podofilox can be increased when combined with Primidone.
PolythiazidePrimidone may increase the orthostatic hypotensive activities of Polythiazide.
PomalidomideThe risk or severity of adverse effects can be increased when Primidone is combined with Pomalidomide.
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with Primidone.
PosaconazoleThe metabolism of Posaconazole can be increased when combined with Primidone.
PractololThe serum concentration of Practolol can be decreased when it is combined with Primidone.
PramipexolePrimidone may increase the sedative activities of Pramipexole.
PramocaineThe risk or severity of adverse effects can be increased when Pramocaine is combined with Primidone.
PrasugrelThe metabolism of Prasugrel can be increased when combined with Primidone.
PravastatinThe metabolism of Pravastatin can be increased when combined with Primidone.
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with Primidone.
PraziquantelThe serum concentration of Praziquantel can be decreased when it is combined with Primidone.
PrazosinPrimidone may increase the hypotensive activities of Prazosin.
PrednicarbateThe serum concentration of Prednicarbate can be decreased when it is combined with Primidone.
PrednisoloneThe serum concentration of Prednisolone can be decreased when it is combined with Primidone.
PrednisoneThe serum concentration of Prednisone can be decreased when it is combined with Primidone.
PregabalinThe metabolism of Pregabalin can be increased when combined with Primidone.
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Primidone.
PregnenoloneThe serum concentration of Pregnenolone can be decreased when it is combined with Primidone.
PrenylamineThe metabolism of Prenylamine can be increased when combined with Primidone.
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Primidone.
PrimaquineThe metabolism of Primaquine can be increased when combined with Primidone.
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Primidone.
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Primidone.
ProgesteroneThe metabolism of Progesterone can be increased when combined with Primidone.
ProguanilThe metabolism of Proguanil can be increased when combined with Primidone.
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Primidone.
PromethazineThe risk or severity of adverse effects can be increased when Primidone is combined with Promethazine.
PropacetamolThe metabolism of Propacetamol can be increased when combined with Primidone.
PropafenoneThe serum concentration of Propafenone can be decreased when it is combined with Primidone.
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Primidone.
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Primidone.
PropoxycaineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Primidone.
PropranololPrimidone may increase the hypotensive activities of Propranolol.
ProtriptylineThe risk or severity of adverse effects can be increased when Protriptyline is combined with Primidone.
PSD502The risk or severity of adverse effects can be increased when PSD502 is combined with Primidone.
PyrazinamideThe metabolism of Pyrazinamide can be increased when combined with Primidone.
PyridoxineThe metabolism of Primidone can be increased when combined with Pyridoxine.
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Primidone.
QuetiapinePrimidone may increase the hypotensive activities of Quetiapine.
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Primidone.
QuinacrineThe metabolism of Quinacrine can be increased when combined with Primidone.
QuinaprilPrimidone may increase the hypotensive activities of Quinapril.
QuinethazonePrimidone may increase the orthostatic hypotensive activities of Quinethazone.
QuinidineThe serum concentration of Quinidine can be decreased when it is combined with Primidone.
QuinineThe metabolism of Quinine can be increased when combined with Primidone.
RabeprazoleThe metabolism of Rabeprazole can be increased when combined with Primidone.
RaloxifeneThe metabolism of Raloxifene can be increased when combined with Primidone.
RamelteonThe risk or severity of adverse effects can be increased when Primidone is combined with Ramelteon.
RamiprilPrimidone may increase the hypotensive activities of Ramipril.
RanitidineThe metabolism of Ranitidine can be increased when combined with Primidone.
RanolazineThe serum concentration of Ranolazine can be decreased when it is combined with Primidone.
RasagilineThe metabolism of Rasagiline can be increased when combined with Primidone.
ReboxetineThe metabolism of Reboxetine can be increased when combined with Primidone.
RegorafenibThe serum concentration of Regorafenib can be decreased when it is combined with Primidone.
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Primidone.
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Primidone.
RepaglinideThe metabolism of Repaglinide can be increased when combined with Primidone.
ReserpinePrimidone may increase the hypotensive activities of Reserpine.
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Primidone.
ResveratrolThe metabolism of Resveratrol can be increased when combined with Primidone.
RetapamulinThe metabolism of Retapamulin can be increased when combined with Primidone.
RifabutinThe metabolism of Rifabutin can be increased when combined with Primidone.
RifampicinThe metabolism of Rifampicin can be increased when combined with Primidone.
RilpivirineThe serum concentration of Rilpivirine can be decreased when it is combined with Primidone.
RiluzoleThe metabolism of Riluzole can be increased when combined with Primidone.
RimexoloneThe serum concentration of Rimexolone can be decreased when it is combined with Primidone.
RimonabantThe metabolism of Rimonabant can be increased when combined with Primidone.
RiociguatPrimidone may increase the hypotensive activities of Riociguat.
RisedronateThe metabolism of Risedronate can be increased when combined with Primidone.
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Primidone.
RitonavirThe metabolism of Ritonavir can be increased when combined with Primidone.
RivaroxabanThe serum concentration of Rivaroxaban can be decreased when it is combined with Primidone.
RizatriptanThe metabolism of Rizatriptan can be increased when combined with Primidone.
RofecoxibThe metabolism of Rofecoxib can be increased when combined with Primidone.
RoflumilastThe serum concentration of Roflumilast can be decreased when it is combined with Primidone.
RolapitantThe serum concentration of Rolapitant can be decreased when it is combined with Primidone.
RomidepsinThe serum concentration of Romidepsin can be decreased when it is combined with Primidone.
RomifidineThe risk or severity of adverse effects can be increased when Romifidine is combined with Primidone.
RopinirolePrimidone may increase the sedative activities of Ropinirole.
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Primidone.
RosiglitazoneThe metabolism of Rosiglitazone can be increased when combined with Primidone.
RosuvastatinThe metabolism of Rosuvastatin can be increased when combined with Primidone.
RotigotinePrimidone may increase the sedative activities of Rotigotine.
RoxithromycinThe metabolism of Roxithromycin can be increased when combined with Primidone.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Primidone.
RufinamideThe serum concentration of Rufinamide can be decreased when it is combined with Primidone.
RuxolitinibThe metabolism of Ruxolitinib can be increased when combined with Primidone.
S-EthylisothioureaThe risk or severity of adverse effects can be increased when S-Ethylisothiourea is combined with Primidone.
Salicylic acidThe metabolism of Salicylic acid can be increased when combined with Primidone.
SalmeterolThe metabolism of Salmeterol can be increased when combined with Primidone.
SaquinavirThe metabolism of Saquinavir can be increased when combined with Primidone.
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Primidone.
ScopolamineThe risk or severity of adverse effects can be increased when Scopolamine is combined with Primidone.
SecobarbitalThe risk or severity of adverse effects can be increased when Primidone is combined with Secobarbital.
SelegilineThe metabolism of Selegiline can be increased when combined with Primidone.
SelexipagThe metabolism of Selexipag can be increased when combined with Primidone.
SeratrodastThe metabolism of Seratrodast can be increased when combined with Primidone.
SertindoleThe risk or severity of adverse effects can be increased when Sertindole is combined with Primidone.
SertralineThe risk or severity of adverse effects can be increased when Primidone is combined with Sertraline.
SertralineThe metabolism of Primidone can be decreased when combined with Sertraline.
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Primidone.
SibutramineThe metabolism of Sibutramine can be increased when combined with Primidone.
SildenafilThe metabolism of Sildenafil can be increased when combined with Primidone.
SilodosinThe metabolism of Silodosin can be increased when combined with Primidone.
SimeprevirThe serum concentration of Simeprevir can be decreased when it is combined with Primidone.
SimvastatinThe metabolism of Simvastatin can be increased when combined with Primidone.
SirolimusThe metabolism of Sirolimus can be increased when combined with Primidone.
SitagliptinThe metabolism of Sitagliptin can be increased when combined with Primidone.
SitaxentanThe metabolism of Sitaxentan can be increased when combined with Primidone.
Sodium oxybateThe risk or severity of adverse effects can be increased when Sodium oxybate is combined with Primidone.
SolifenacinThe metabolism of Solifenacin can be increased when combined with Primidone.
SomatostatinThe risk or severity of adverse effects can be increased when Somatostatin is combined with Primidone.
SonidegibThe serum concentration of Sonidegib can be decreased when it is combined with Primidone.
SorafenibThe serum concentration of Sorafenib can be decreased when it is combined with Primidone.
SotalolPrimidone may increase the hypotensive activities of Sotalol.
SpiramycinThe metabolism of Spiramycin can be increased when combined with Primidone.
SpironolactonePrimidone may increase the hypotensive activities of Spironolactone.
StiripentolThe risk or severity of adverse effects can be increased when Primidone is combined with Stiripentol.
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Primidone.
SulfadiazineThe metabolism of Sulfadiazine can be increased when combined with Primidone.
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be increased when combined with Primidone.
SulfamoxoleThe metabolism of Sulfamoxole can be increased when combined with Primidone.
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be increased when combined with Primidone.
SulfisoxazoleThe metabolism of Sulfisoxazole can be increased when combined with Primidone.
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Primidone.
SunitinibThe serum concentration of Sunitinib can be decreased when it is combined with Primidone.
SuprofenThe metabolism of Suprofen can be increased when combined with Primidone.
SuvorexantThe serum concentration of Suvorexant can be decreased when it is combined with Primidone.
SuvorexantThe risk or severity of adverse effects can be increased when Suvorexant is combined with Primidone.
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be increased when combined with Primidone.
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be increased when combined with Primidone.
TacrineThe metabolism of Tacrine can be increased when combined with Primidone.
TacrolimusThe metabolism of Tacrolimus can be increased when combined with Primidone.
TadalafilThe serum concentration of Tadalafil can be decreased when it is combined with Primidone.
TamoxifenThe metabolism of Tamoxifen can be increased when combined with Primidone.
TamsulosinThe metabolism of Tamsulosin can be increased when combined with Primidone.
TapentadolThe risk or severity of adverse effects can be increased when Primidone is combined with Tapentadol.
TasimelteonThe serum concentration of Tasimelteon can be decreased when it is combined with Primidone.
TasimelteonThe risk or severity of adverse effects can be increased when Tasimelteon is combined with Primidone.
TasosartanThe metabolism of Tasosartan can be increased when combined with Primidone.
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be increased when combined with Primidone.
TazaroteneThe metabolism of Tazarotene can be increased when combined with Primidone.
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Primidone.
TelithromycinThe metabolism of Telithromycin can be increased when combined with Primidone.
TelmisartanPrimidone may increase the hypotensive activities of Telmisartan.
TemafloxacinThe metabolism of Temafloxacin can be increased when combined with Primidone.
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Primidone.
TemsirolimusThe metabolism of Temsirolimus can be increased when combined with Primidone.
TeniposideThe serum concentration of Teniposide can be decreased when it is combined with Primidone.
TenoxicamThe metabolism of Tenoxicam can be increased when combined with Primidone.
TerazosinPrimidone may increase the hypotensive activities of Terazosin.
TerbinafineThe metabolism of Terbinafine can be increased when combined with Primidone.
TerfenadineThe metabolism of Terfenadine can be increased when combined with Primidone.
TesmilifeneThe metabolism of Tesmilifene can be increased when combined with Primidone.
TestosteroneThe metabolism of Testosterone can be increased when combined with Primidone.
TetrabenazineThe risk or severity of adverse effects can be increased when Primidone is combined with Tetrabenazine.
TetracaineThe risk or severity of adverse effects can be increased when Tetracaine is combined with Primidone.
TetracyclineThe metabolism of Tetracycline can be increased when combined with Primidone.
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Primidone.
ThalidomidePrimidone may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Primidone.
TheobromineThe metabolism of Theobromine can be increased when combined with Primidone.
TheophyllineThe serum concentration of Theophylline can be decreased when it is combined with Primidone.
ThiabendazoleThe metabolism of Thiabendazole can be increased when combined with Primidone.
ThiamylalThe risk or severity of adverse effects can be increased when Primidone is combined with Thiamylal.
ThiopentalThe risk or severity of adverse effects can be increased when Primidone is combined with Thiopental.
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Primidone.
ThiotepaThe metabolism of Thiotepa can be increased when combined with Primidone.
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Primidone.
TiagabineThe risk or severity of adverse effects can be increased when Primidone is combined with Tiagabine.
TianeptineThe metabolism of Tianeptine can be increased when combined with Primidone.
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Primidone resulting in a loss in efficacy.
TiclopidineThe metabolism of Ticlopidine can be increased when combined with Primidone.
TiletamineThe risk or severity of adverse effects can be increased when Tiletamine is combined with Primidone.
TimololPrimidone may increase the hypotensive activities of Timolol.
TinidazoleThe metabolism of Tinidazole can be increased when combined with Primidone.
TiotropiumThe metabolism of Tiotropium can be increased when combined with Primidone.
TipranavirThe metabolism of Tipranavir can be increased when combined with Primidone.
TixocortolThe serum concentration of Tixocortol can be decreased when it is combined with Primidone.
TizanidinePrimidone may increase the hypotensive activities of Tizanidine.
TizanidineThe risk or severity of adverse effects can be increased when Tizanidine is combined with Primidone.
TofacitinibThe serum concentration of Tofacitinib can be decreased when it is combined with Primidone.
TolbutamideThe metabolism of Tolbutamide can be increased when combined with Primidone.
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Primidone.
Tolfenamic AcidThe metabolism of Tolfenamic Acid can be increased when combined with Primidone.
TolterodineThe metabolism of Tolterodine can be increased when combined with Primidone.
TolvaptanThe serum concentration of Tolvaptan can be decreased when it is combined with Primidone.
TopiramateThe risk or severity of adverse effects can be increased when Topiramate is combined with Primidone.
TorasemidePrimidone may increase the hypotensive activities of Torasemide.
ToremifeneThe serum concentration of Toremifene can be decreased when it is combined with Primidone.
TrabectedinThe serum concentration of Trabectedin can be decreased when it is combined with Primidone.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Primidone.
TrandolaprilPrimidone may increase the hypotensive activities of Trandolapril.
TranilastThe metabolism of Tranilast can be increased when combined with Primidone.
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with Primidone.
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Primidone.
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be increased when combined with Primidone.
TrazodoneThe risk or severity of adverse effects can be increased when Primidone is combined with Trazodone.
TreprostinilThe serum concentration of Treprostinil can be decreased when it is combined with Primidone.
TretinoinThe metabolism of Tretinoin can be increased when combined with Primidone.
TriamcinoloneThe serum concentration of Triamcinolone can be decreased when it is combined with Primidone.
TriamterenePrimidone may increase the hypotensive activities of Triamterene.
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Primidone.
TrichlormethiazidePrimidone may increase the orthostatic hypotensive activities of Trichlormethiazide.
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Primidone.
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Primidone.
TrimethadioneThe metabolism of Trimethadione can be increased when combined with Primidone.
TrimethoprimThe metabolism of Trimethoprim can be increased when combined with Primidone.
TrimipramineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Primidone.
TriprolidineThe risk or severity of adverse effects can be increased when Triprolidine is combined with Primidone.
TroglitazoneThe metabolism of Troglitazone can be increased when combined with Primidone.
TroleandomycinThe metabolism of Troleandomycin can be increased when combined with Primidone.
UdenafilThe metabolism of Udenafil can be increased when combined with Primidone.
UlipristalThe serum concentration of Ulipristal can be decreased when it is combined with Primidone.
ValdecoxibThe metabolism of Valdecoxib can be increased when combined with Primidone.
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Primidone.
ValsartanPrimidone may increase the hypotensive activities of Valsartan.
VandetanibThe serum concentration of Vandetanib can be decreased when it is combined with Primidone.
VanoxerineThe metabolism of Vanoxerine can be increased when combined with Primidone.
VardenafilThe metabolism of Vardenafil can be increased when combined with Primidone.
VemurafenibThe serum concentration of Vemurafenib can be decreased when it is combined with Primidone.
VenlafaxineThe metabolism of Venlafaxine can be increased when combined with Primidone.
VerapamilPrimidone may increase the hypotensive activities of Verapamil.
VicrivirocThe metabolism of Vicriviroc can be increased when combined with Primidone.
VigabatrinThe risk or severity of adverse effects can be increased when Primidone is combined with Vigabatrin.
VilanterolThe metabolism of Vilanterol can be increased when combined with Primidone.
VilazodoneThe risk or severity of adverse effects can be increased when Primidone is combined with Vilazodone.
VinblastineThe metabolism of Vinblastine can be increased when combined with Primidone.
VincristineThe serum concentration of Vincristine can be decreased when it is combined with Primidone.
VindesineThe metabolism of Vindesine can be increased when combined with Primidone.
VinorelbineThe metabolism of Vinorelbine can be increased when combined with Primidone.
VismodegibThe metabolism of Vismodegib can be increased when combined with Primidone.
VorapaxarThe serum concentration of Vorapaxar can be decreased when it is combined with Primidone.
VoriconazoleThe serum concentration of Voriconazole can be decreased when it is combined with Primidone.
VoriconazoleThe metabolism of Primidone can be decreased when combined with Voriconazole.
VortioxetineThe risk or severity of adverse effects can be increased when Primidone is combined with Vortioxetine.
WarfarinThe metabolism of Warfarin can be increased when combined with Primidone.
XimelagatranThe metabolism of Ximelagatran can be increased when combined with Primidone.
XylazineThe risk or severity of adverse effects can be increased when Xylazine is combined with Primidone.
XylometazolineThe metabolism of Xylometazoline can be increased when combined with Primidone.
YohimbineThe metabolism of Yohimbine can be increased when combined with Primidone.
ZafirlukastThe metabolism of Zafirlukast can be increased when combined with Primidone.
ZalcitabineThe metabolism of Zalcitabine can be increased when combined with Primidone.
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Primidone.
ZaltoprofenThe metabolism of Zaltoprofen can be increased when combined with Primidone.
ZiconotideThe metabolism of Ziconotide can be increased when combined with Primidone.
ZiconotideThe risk or severity of adverse effects can be increased when Ziconotide is combined with Primidone.
ZidovudineThe metabolism of Zidovudine can be increased when combined with Primidone.
ZileutonThe metabolism of Zileuton can be increased when combined with Primidone.
ZimelidineThe risk or severity of adverse effects can be increased when Primidone is combined with Zimelidine.
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Primidone.
ZolazepamThe risk or severity of adverse effects can be increased when Zolazepam is combined with Primidone.
ZolmitriptanThe metabolism of Zolmitriptan can be increased when combined with Primidone.
ZolpidemThe risk or severity of adverse effects can be increased when Zolpidem is combined with Primidone.
ZomepiracThe metabolism of Zomepirac can be increased when combined with Primidone.
ZonisamideThe risk or severity of adverse effects can be increased when Primidone is combined with Zonisamide.
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Primidone.
ZotepineThe risk or severity of adverse effects can be increased when Zotepine is combined with Primidone.
ZuclopenthixolThe serum concentration of Zuclopenthixol can be decreased when it is combined with Primidone.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Primidone.
Food Interactions
  • Avoid alcohol.
  • Avoid high doses of caffeine.
  • Take with food to reduce gastric irritation.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
potentiator
General Function:
Inhibitory extracellular ligand-gated ion channel activity
Specific Function:
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By si...
Gene Name:
GABRA1
Uniprot ID:
P14867
Molecular Weight:
51801.395 Da
References
  1. Whiting PJ: The GABAA receptor gene family: new opportunities for drug development. Curr Opin Drug Discov Devel. 2003 Sep;6(5):648-57. [PubMed:14579514 ]
  2. Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. [PubMed:10209232 ]
  3. Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. [PubMed:11264449 ]
  4. Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. [PubMed:10487207 ]
  5. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  6. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  7. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
potentiator
General Function:
Inhibitory extracellular ligand-gated ion channel activity
Specific Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Gene Name:
GABRA2
Uniprot ID:
P47869
Molecular Weight:
51325.85 Da
References
  1. Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. [PubMed:11264449 ]
  2. Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. [PubMed:10209232 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
potentiator
General Function:
Inhibitory extracellular ligand-gated ion channel activity
Specific Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Gene Name:
GABRA3
Uniprot ID:
P34903
Molecular Weight:
55164.055 Da
References
  1. Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. [PubMed:11264449 ]
  2. Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. [PubMed:10209232 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
potentiator
General Function:
Inhibitory extracellular ligand-gated ion channel activity
Specific Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Gene Name:
GABRA4
Uniprot ID:
P48169
Molecular Weight:
61622.645 Da
References
  1. Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. [PubMed:10209232 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
potentiator
General Function:
Transporter activity
Specific Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Gene Name:
GABRA5
Uniprot ID:
P31644
Molecular Weight:
52145.645 Da
References
  1. Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. [PubMed:11264449 ]
  2. Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. [PubMed:10209232 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
potentiator
General Function:
Inhibitory extracellular ligand-gated ion channel activity
Specific Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Gene Name:
GABRA6
Uniprot ID:
Q16445
Molecular Weight:
51023.69 Da
References
  1. Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. [PubMed:10209232 ]
  2. Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. [PubMed:11264449 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Ligand-gated ion channel activity
Specific Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.
Gene Name:
CHRNA4
Uniprot ID:
P43681
Molecular Weight:
69956.47 Da
References
  1. Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. [PubMed:11264449 ]
  2. Arias HR, Bhumireddy P: Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors. Curr Protein Pept Sci. 2005 Oct;6(5):451-72. [PubMed:16248797 ]
  3. Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. [PubMed:10487207 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Toxic substance binding
Specific Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
Gene Name:
CHRNA7
Uniprot ID:
P36544
Molecular Weight:
56448.925 Da
References
  1. Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. [PubMed:11264449 ]
  2. Arias HR, Bhumireddy P: Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors. Curr Protein Pept Sci. 2005 Oct;6(5):451-72. [PubMed:16248797 ]
  3. Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. [PubMed:10487207 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Ionotropic glutamate receptor activity
Specific Function:
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and t...
Gene Name:
GRIA2
Uniprot ID:
P42262
Molecular Weight:
98820.32 Da
References
  1. Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. [PubMed:11264449 ]
  2. Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. [PubMed:10487207 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Kainate selective glutamate receptor activity
Specific Function:
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inacti...
Gene Name:
GRIK2
Uniprot ID:
Q13002
Molecular Weight:
102582.475 Da
References
  1. Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. [PubMed:11264449 ]
  2. Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. [PubMed:10487207 ]
Kind
Protein group
Organism
Human
Pharmacological action
yes
Actions
positive allosteric modulator
General Function:
Inhibitory extracellular ligand-gated ion channel activity
Specific Function:
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).
Components:
NameUniProt IDDetails
Gamma-aminobutyric acid receptor subunit alpha-1P14867 Details
Gamma-aminobutyric acid receptor subunit alpha-2P47869 Details
Gamma-aminobutyric acid receptor subunit alpha-3P34903 Details
Gamma-aminobutyric acid receptor subunit alpha-4P48169 Details
Gamma-aminobutyric acid receptor subunit alpha-5P31644 Details
Gamma-aminobutyric acid receptor subunit alpha-6Q16445 Details
Gamma-aminobutyric acid receptor subunit beta-1P18505 Details
Gamma-aminobutyric acid receptor subunit beta-2P47870 Details
Gamma-aminobutyric acid receptor subunit beta-3P28472 Details
Gamma-aminobutyric acid receptor subunit deltaO14764 Details
Gamma-aminobutyric acid receptor subunit epsilonP78334 Details
Gamma-aminobutyric acid receptor subunit gamma-1Q8N1C3 Details
Gamma-aminobutyric acid receptor subunit gamma-2P18507 Details
Gamma-aminobutyric acid receptor subunit gamma-3Q99928 Details
Gamma-aminobutyric acid receptor subunit piO00591 Details
Gamma-aminobutyric acid receptor subunit thetaQ9UN88 Details
References
  1. ChEMBL Compound Report Card [Link]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
  3. The P450 Program [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23