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Identification
NameClofazimine
Accession NumberDB00845  (APRD00278)
TypeSmall Molecule
GroupsApproved, Investigational
DescriptionA fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
Structure
Thumb
Synonyms
Clofazimin
Clofazimina
Clofazimine
Clofaziminum
Lamprene
Riminophenazine
External Identifiers
  • B 663
  • G 30320
  • NSC 141046
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
ClofozineAstraZeneca
HansepranAbbott
LamcoinPond's Chemical
LamprenNovartis
LamprèneNovartis
LampreneNovartis
Brand mixturesNot Available
SaltsNot Available
Categories
UNIID959AE5USF
CAS number2030-63-9
WeightAverage: 473.396
Monoisotopic: 472.122152138
Chemical FormulaC27H22Cl2N4
InChI KeyInChIKey=WDQPAMHFFCXSNU-BGABXYSRSA-N
InChI
InChI=1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3/b30-24+
IUPAC Name
N,5-bis(4-chlorophenyl)-3-[(propan-2-yl)imino]-3,5-dihydrophenazin-2-amine
SMILES
CC(C)N=C1C=C2N(C3=CC=C(Cl)C=C3)C3=C(C=CC=C3)N=C2C=C1NC1=CC=C(Cl)C=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenazines and derivatives. These are polycyclic aromatic compounds containing a phenazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a pyrazine ring.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassNaphthyridines
Sub ClassQuinoxalines
Direct ParentPhenazines and derivatives
Alternative Parents
Substituents
  • Phenazine
  • Substituted aniline
  • Halobenzene
  • Chlorobenzene
  • Aniline
  • Benzenoid
  • Pyrazine
  • Monocyclic benzene moiety
  • Aryl halide
  • Aryl chloride
  • Heteroaromatic compound
  • Secondary ketimine
  • Azacycle
  • Secondary amine
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of lepromatous leprosy, including dapsone-resistant lepromatous leprosy and lepromatous leprosy complicated by erythema nodosum leprosum.
PharmacodynamicsClofazimine exerts a slow bactericidal effect on Mycobacterium leprae (Hansen's bacillus). Clofazimine inhibits mycobacterial growth and binds preferentially to mycobacterial DNA. Clofazimine also exerts antiinflammatory properties in controlling erythema nodosum leprosum reactions. Clofazimine is highly lipophilic and tends to be deposited predominantly in fatty tissue and in cells of the reticuloendothelial system. It is taken up by macrophages throughout the body. Measurement of the minimum inhibitory concentration (MIC) of clofazimine against leprosy bacilli in vitro is not yet feasible. In the mouse footpad system, the multiplication of M.leprae is inhibited by introducing 0.0001%- 0.001% clofazimine in the diet. Although bacterial killing may begin shortly after starting the drug, it cannot be measured in biopsy tissues taken from patients for mouse footpad studies until approximately 50 days after the start of therapy.
Mechanism of actionAppears to preferentially bind to mycobacterial DNA leading to disruption of the cell cycle and eventually kills the bacterium. It may also bind to bacterial potassium transporters, thereby inhibiting their function. Lysophospholipids have been found to mediate the activity of this drug.
Related Articles
AbsorptionAbsorption varies from 45 to 62% following oral administration in leprosy patients. Bioavailability is approximately 70%. Food increases bioavailability and rate of absorption.
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Hepatic. Three metabolites have been identified - two conjugated and one unconjugated, however, it is not yet known whether these metabolites are pharmacologically active. Metabolite I is formed by hydrolytic dehalogenation of clofazimine, metabolite II presumably is formed by a hydrolytic deamination reaction followed by glucuronidation, and metabolite III appears to be a hydrated clofazimine glucuronide.

SubstrateEnzymesProduct
Clofazimine
Not Available
clofazimine glucuronideDetails
Route of eliminationNot Available
Half life10 days following a single dose, 70 days after long-term, high-dose therapy.
ClearanceNot Available
ToxicityOral, rabbit: LD50 = 3.3 g/kg; Oral, mouse: LD50 = > 4 g/kg. Severe abdominal symptoms have necessitated exploratory laparotomies in some patients on clofazimine therapy. Rare reports have included splenic infarction, bowel obstruction, and gastrointestinal bleeding. Deaths have been reported, following severe abdominal symptoms.
Affected organisms
  • Mycobacteria
  • Mycobacterium leprae
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9881
Blood Brain Barrier+0.7616
Caco-2 permeable+0.6769
P-glycoprotein substrateNon-substrate0.5905
P-glycoprotein inhibitor IInhibitor0.642
P-glycoprotein inhibitor IIInhibitor0.8387
Renal organic cation transporterNon-inhibitor0.6719
CYP450 2C9 substrateNon-substrate0.7897
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.6032
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorInhibitor0.8932
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.8309
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.9292
Ames testAMES toxic0.649
CarcinogenicityNon-carcinogens0.7244
BiodegradationNot ready biodegradable1.0
Rat acute toxicity1.7821 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9805
hERG inhibition (predictor II)Inhibitor0.5826
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Novartis pharmaceuticals corp
Packagers
Dosage formsNot Available
Prices
Unit descriptionCostUnit
Clofazimine powder187.2USD g
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point210-212 °CPhysProp
water solubility0.225 mg/L (virtually insoluble)Not Available
logP7.66QUIGLEY,JM ET AL. (1990)
pKa8.51QUIGLEY,JM ET AL. (1990)
Predicted Properties
PropertyValueSource
Water Solubility0.00151 mg/mLALOGPS
logP7.39ALOGPS
logP7.3ChemAxon
logS-5.5ALOGPS
pKa (Strongest Acidic)16.15ChemAxon
pKa (Strongest Basic)9.29ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area39.99 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity142.55 m3·mol-1ChemAxon
Polarizability51.52 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesJ04BA01
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelDownload (161 KB)
MSDSDownload (73.5 KB)
Interactions
Drug Interactions
Drug
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Clofazimine.
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Clofazimine.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Clofazimine.
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Clofazimine.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Clofazimine.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Clofazimine.
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Clofazimine.
AmiodaroneThe metabolism of Clofazimine can be decreased when combined with Amiodarone.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Clofazimine.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Clofazimine.
AprepitantThe serum concentration of Clofazimine can be increased when it is combined with Aprepitant.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Clofazimine.
AtazanavirThe metabolism of Clofazimine can be decreased when combined with Atazanavir.
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Clofazimine.
AtenololThe serum concentration of Atenolol can be increased when it is combined with Clofazimine.
AtomoxetineThe metabolism of Clofazimine can be decreased when combined with Atomoxetine.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Clofazimine.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Clofazimine.
BexaroteneThe serum concentration of Clofazimine can be decreased when it is combined with Bexarotene.
BoceprevirThe metabolism of Clofazimine can be decreased when combined with Boceprevir.
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Clofazimine.
BortezomibThe metabolism of Clofazimine can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Clofazimine can be decreased when it is combined with Bosentan.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Clofazimine.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Clofazimine.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Clofazimine.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Clofazimine.
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Clofazimine.
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Clofazimine.
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Clofazimine.
CarbamazepineThe metabolism of Clofazimine can be increased when combined with Carbamazepine.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Clofazimine.
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Clofazimine.
CeritinibThe serum concentration of Clofazimine can be increased when it is combined with Ceritinib.
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Clofazimine.
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Clofazimine.
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Clofazimine.
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Clofazimine.
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Clofazimine.
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Clofazimine.
ClarithromycinThe metabolism of Clofazimine can be decreased when combined with Clarithromycin.
ClarithromycinThe serum concentration of Clarithromycin can be increased when it is combined with Clofazimine.
ClemastineThe metabolism of Clofazimine can be decreased when combined with Clemastine.
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Clofazimine.
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Clofazimine.
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Clofazimine.
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Clofazimine.
ClotrimazoleThe metabolism of Clofazimine can be decreased when combined with Clotrimazole.
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Clofazimine.
CobicistatThe metabolism of Clofazimine can be decreased when combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Clofazimine.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Clofazimine.
ConivaptanThe serum concentration of Clofazimine can be increased when it is combined with Conivaptan.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Clofazimine.
CrizotinibThe metabolism of Clofazimine can be decreased when combined with Crizotinib.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Clofazimine.
CyclosporineThe metabolism of Clofazimine can be decreased when combined with Cyclosporine.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Clofazimine.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Clofazimine.
DabrafenibThe serum concentration of Clofazimine can be decreased when it is combined with Dabrafenib.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Clofazimine.
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Clofazimine.
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Clofazimine.
DarunavirThe metabolism of Clofazimine can be decreased when combined with Darunavir.
DasatinibThe serum concentration of Clofazimine can be increased when it is combined with Dasatinib.
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Clofazimine.
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Clofazimine.
DeferasiroxThe serum concentration of Clofazimine can be decreased when it is combined with Deferasirox.
DelavirdineThe metabolism of Clofazimine can be decreased when combined with Delavirdine.
DexamethasoneThe serum concentration of Clofazimine can be decreased when it is combined with Dexamethasone.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Clofazimine.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Clofazimine.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Clofazimine.
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Clofazimine.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Clofazimine.
DihydroergotamineThe metabolism of Clofazimine can be decreased when combined with Dihydroergotamine.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Clofazimine.
DiltiazemThe metabolism of Clofazimine can be decreased when combined with Diltiazem.
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Clofazimine.
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Clofazimine.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Clofazimine.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Clofazimine.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Clofazimine.
DoxycyclineThe metabolism of Clofazimine can be decreased when combined with Doxycycline.
DronedaroneThe metabolism of Clofazimine can be decreased when combined with Dronedarone.
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Clofazimine.
EfavirenzThe serum concentration of Clofazimine can be decreased when it is combined with Efavirenz.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Clofazimine.
EnzalutamideThe serum concentration of Clofazimine can be decreased when it is combined with Enzalutamide.
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Clofazimine.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Clofazimine.
ErythromycinThe metabolism of Clofazimine can be decreased when combined with Erythromycin.
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Clofazimine.
Eslicarbazepine acetateThe serum concentration of Clofazimine can be decreased when it is combined with Eslicarbazepine acetate.
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Clofazimine.
EstriolThe serum concentration of Estriol can be increased when it is combined with Clofazimine.
EstroneThe serum concentration of Estrone can be increased when it is combined with Clofazimine.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Clofazimine.
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Clofazimine.
EtravirineThe serum concentration of Clofazimine can be decreased when it is combined with Etravirine.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Clofazimine.
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Clofazimine.
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Clofazimine.
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Clofazimine.
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Clofazimine.
FluconazoleThe metabolism of Clofazimine can be decreased when combined with Fluconazole.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Clofazimine.
FluvoxamineThe metabolism of Clofazimine can be decreased when combined with Fluvoxamine.
FosamprenavirThe metabolism of Clofazimine can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Clofazimine can be increased when it is combined with Fosaprepitant.
FosphenytoinThe metabolism of Clofazimine can be increased when combined with Fosphenytoin.
Fusidic AcidThe serum concentration of Clofazimine can be increased when it is combined with Fusidic Acid.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Clofazimine.
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Clofazimine.
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Clofazimine.
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Clofazimine.
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Clofazimine.
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Clofazimine.
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Clofazimine.
IdelalisibThe serum concentration of Clofazimine can be increased when it is combined with Idelalisib.
ImatinibThe metabolism of Clofazimine can be decreased when combined with Imatinib.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Clofazimine.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Clofazimine.
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Clofazimine.
IndinavirThe metabolism of Clofazimine can be decreased when combined with Indinavir.
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Clofazimine.
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Clofazimine.
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Clofazimine.
IsavuconazoniumThe metabolism of Clofazimine can be decreased when combined with Isavuconazonium.
IsradipineThe metabolism of Clofazimine can be decreased when combined with Isradipine.
ItraconazoleThe metabolism of Clofazimine can be decreased when combined with Itraconazole.
IvacaftorThe serum concentration of Clofazimine can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Clofazimine.
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Clofazimine.
KetoconazoleThe metabolism of Clofazimine can be decreased when combined with Ketoconazole.
KetoconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Clofazimine.
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Clofazimine.
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Clofazimine.
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Clofazimine.
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Clofazimine.
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Clofazimine.
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Clofazimine.
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Clofazimine.
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Clofazimine.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Clofazimine.
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Clofazimine.
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Clofazimine.
LopinavirThe metabolism of Clofazimine can be decreased when combined with Lopinavir.
LosartanThe serum concentration of Losartan can be increased when it is combined with Clofazimine.
LovastatinThe metabolism of Clofazimine can be decreased when combined with Lovastatin.
LuliconazoleThe serum concentration of Clofazimine can be increased when it is combined with Luliconazole.
MannitolThe serum concentration of Mannitol can be increased when it is combined with Clofazimine.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Clofazimine.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Clofazimine.
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Clofazimine.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Clofazimine.
MifepristoneThe metabolism of Clofazimine can be decreased when combined with Mifepristone.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Clofazimine.
MitotaneThe serum concentration of Clofazimine can be decreased when it is combined with Mitotane.
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Clofazimine.
ModafinilThe serum concentration of Clofazimine can be decreased when it is combined with Modafinil.
MorphineThe serum concentration of Morphine can be increased when it is combined with Clofazimine.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Clofazimine.
NadololThe serum concentration of Nadolol can be increased when it is combined with Clofazimine.
NafcillinThe serum concentration of Clofazimine can be decreased when it is combined with Nafcillin.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Clofazimine.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Clofazimine.
NefazodoneThe metabolism of Clofazimine can be decreased when combined with Nefazodone.
NelfinavirThe metabolism of Clofazimine can be decreased when combined with Nelfinavir.
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Clofazimine.
NetupitantThe serum concentration of Clofazimine can be increased when it is combined with Netupitant.
NevirapineThe metabolism of Clofazimine can be decreased when combined with Nevirapine.
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Clofazimine.
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Clofazimine.
NilotinibThe metabolism of Clofazimine can be decreased when combined with Nilotinib.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Clofazimine.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Clofazimine.
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Clofazimine.
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Clofazimine.
OlaparibThe metabolism of Clofazimine can be decreased when combined with Olaparib.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Clofazimine.
OsimertinibThe serum concentration of Clofazimine can be increased when it is combined with Osimertinib.
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Clofazimine.
PalbociclibThe serum concentration of Clofazimine can be increased when it is combined with Palbociclib.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Clofazimine.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Clofazimine.
PentobarbitalThe metabolism of Clofazimine can be increased when combined with Pentobarbital.
PhenobarbitalThe metabolism of Clofazimine can be increased when combined with Phenobarbital.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Clofazimine.
PhenytoinThe metabolism of Clofazimine can be increased when combined with Phenytoin.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Clofazimine.
Picosulfuric acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Clofazimine.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Clofazimine.
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Clofazimine.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Clofazimine.
PosaconazoleThe metabolism of Clofazimine can be decreased when combined with Posaconazole.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Clofazimine.
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Clofazimine.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Clofazimine.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Clofazimine.
PrimidoneThe metabolism of Clofazimine can be increased when combined with Primidone.
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Clofazimine.
PropranololThe serum concentration of Propranolol can be increased when it is combined with Clofazimine.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Clofazimine.
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Clofazimine.
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Clofazimine.
QuinineThe serum concentration of Quinine can be increased when it is combined with Clofazimine.
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Clofazimine.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Clofazimine.
RanolazineThe metabolism of Clofazimine can be decreased when combined with Ranolazine.
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Clofazimine.
RifabutinThe metabolism of Clofazimine can be increased when combined with Rifabutin.
RifampicinThe metabolism of Clofazimine can be increased when combined with Rifampicin.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Clofazimine.
RifapentineThe metabolism of Clofazimine can be increased when combined with Rifapentine.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Clofazimine.
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Clofazimine.
RitonavirThe metabolism of Clofazimine can be decreased when combined with Ritonavir.
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Clofazimine.
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Clofazimine.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Clofazimine.
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Clofazimine.
SaquinavirThe metabolism of Clofazimine can be decreased when combined with Saquinavir.
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Clofazimine.
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Clofazimine.
SildenafilThe metabolism of Clofazimine can be decreased when combined with Sildenafil.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Clofazimine.
SiltuximabThe serum concentration of Clofazimine can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Clofazimine can be increased when it is combined with Simeprevir.
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Clofazimine.
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Clofazimine.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Clofazimine.
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Clofazimine.
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Clofazimine.
St. John's WortThe serum concentration of Clofazimine can be decreased when it is combined with St. John's Wort.
StiripentolThe serum concentration of Clofazimine can be increased when it is combined with Stiripentol.
SulfisoxazoleThe metabolism of Clofazimine can be decreased when combined with Sulfisoxazole.
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Clofazimine.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Clofazimine.
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Clofazimine.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Clofazimine.
TelaprevirThe metabolism of Clofazimine can be decreased when combined with Telaprevir.
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Clofazimine.
TelithromycinThe metabolism of Clofazimine can be decreased when combined with Telithromycin.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Clofazimine.
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Clofazimine.
TiclopidineThe metabolism of Clofazimine can be decreased when combined with Ticlopidine.
TimololThe serum concentration of Timolol can be increased when it is combined with Clofazimine.
TocilizumabThe serum concentration of Clofazimine can be decreased when it is combined with Tocilizumab.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Clofazimine.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Clofazimine.
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Clofazimine.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Clofazimine.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Clofazimine.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Clofazimine.
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Clofazimine.
VenlafaxineThe metabolism of Clofazimine can be decreased when combined with Venlafaxine.
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Clofazimine.
VerapamilThe metabolism of Clofazimine can be decreased when combined with Verapamil.
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Clofazimine.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Clofazimine.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Clofazimine.
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Clofazimine.
VoriconazoleThe metabolism of Clofazimine can be decreased when combined with Voriconazole.
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Clofazimine.
ZiprasidoneThe metabolism of Clofazimine can be decreased when combined with Ziprasidone.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Geobacillus kaustophilus (strain HTA426)
Pharmacological action
yes
Actions
inhibitor
General Function:
Oxidoreductase activity
Specific Function:
Not Available
Gene Name:
Not Available
Uniprot ID:
Q5L2G3
Molecular Weight:
39136.585 Da
References
  1. Cholo MC, Boshoff HI, Steel HC, Cockeran R, Matlola NM, Downing KJ, Mizrahi V, Anderson R: Effects of clofazimine on potassium uptake by a Trk-deletion mutant of Mycobacterium tuberculosis. J Antimicrob Chemother. 2006 Jan;57(1):79-84. Epub 2005 Nov 12. [PubMed:16286358 ]
2. DNA
Kind
Nucleotide
Organism
Human
Pharmacological action
yes
Actions
intercalation
General Function:
Used for biological information storage.
Specific Function:
DNA contains the instructions needed for an organism to develop, survive and reproduce.
Molecular Weight:
2.15 x 1012 Da
References
  1. Arbiser JL, Moschella SL: Clofazimine: a review of its medical uses and mechanisms of action. J Am Acad Dermatol. 1995 Feb;32(2 Pt 1):241-7. [PubMed:7829710 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. [PubMed:11716514 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Transporter activity
Specific Function:
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
Gene Name:
ABCB11
Uniprot ID:
O95342
Molecular Weight:
146405.83 Da
References
  1. Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. [PubMed:12739759 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Transporter activity
Specific Function:
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
Gene Name:
ABCB11
Uniprot ID:
O95342
Molecular Weight:
146405.83 Da
References
  1. Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. [PubMed:12739759 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. [PubMed:11716514 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23