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Identification
NameGuaifenesin
Accession NumberDB00874  (APRD01005)
TypeSmall Molecule
GroupsApproved
Description

An expectorant that also has some muscle relaxing action. It is used in many cough preparations. [PubChem]

Structure
Thumb
Synonyms
SynonymLanguageCode
Glyceryl guaiacolateNot AvailableNot Available
guaiphenesinNot AvailableNot Available
HustosilNot AvailableNot Available
RobitussinNot AvailableNot Available
Prescription ProductsNot Available
Generic Prescription ProductsNot Available
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Robitussin Mucus Plus Chest Congestionliquid100 mg/5mLoralRichmond Division of Wyeth2012-07-18Not AvailableUs
Good Sense Mucus Reliefliquid100 mg/5mLoralL Perrigo Company2007-11-06Not AvailableUs
Good Sense Tussin chest congestionsyrup100 mg/5mLoralL Perrigo Company1991-01-15Not AvailableUs
Good Sense Mucus Ertablet, extended release600 mgoralL. Perrigo Company2013-03-21Not AvailableUs
Tussin mucus plus chest congestionsyrup200 mg/10mLoralL Perrigo Company1987-07-15Not AvailableUs
Tussinsyrup100 mg/5mLoralL Perrigo Company1987-07-15Not AvailableUs
Guaifenesinsolution100 mg/5mLoralPharmaceutical Associates, Inc.2002-09-01Not AvailableUs
Guaifenesinsolution100 mg/5mLoralPharmaceutical Associates, Inc.2002-09-01Not AvailableUs
Childrens Chest Congestionliquid100 mg/5mLoralWalgreen Company2007-08-30Not AvailableUs
Wal Tussin adult chest congestionsyrup200 mg/10mLoralWalgreen Company1995-10-13Not AvailableUs
Mucus Relief Ertablet, extended release600 mgoralWalgreen Company2013-03-18Not AvailableUs
Mucus Relieftablet400 mgoralWALGREEN CO.2005-12-22Not AvailableUs
Scot-tussin Expectorant Sf Coughliquid100 mg/5mLoralScot Tussin Pharmacal Co., Inc.1974-07-01Not AvailableUs
Coughliquid100 mg/5mLoralRugby Laboratories Inc.2009-12-04Not AvailableUs
Rugby Mucus Ertablet, extended release600 mgoralRugby Laboratories2014-10-27Not AvailableUs
Qtussinsolution100 mg/5mLoralQualitest Pharmaceuticals1997-10-01Not AvailableUs
Iophen Nrliquid100 mg/5mLoralQualitest Pharmaceuticals1997-05-01Not AvailableUs
Organ-i Nrtablet200 mgoralQualitest Pharmaceuticals2002-07-01Not AvailableUs
Robafen Cough Formulasyrup100 mg/5mLoralMajor Pharmaceuticals2012-08-15Not AvailableUs
Guaifenesintablet200 mgoralMajor Pharmaceuticals2009-10-05Not AvailableUs
Mucus Relieftablet400 mgoralMajor Pharmaceuticals2005-12-22Not AvailableUs
Mucus Ertablet, extended release600 mgoralMajor Pharmaceuticals2013-03-20Not AvailableUs
Mucus Relieftablet400 mgoralMajor Pharmaceuticals Inc2012-07-23Not AvailableUs
7 Select Mucus Relieftablet, extended release600 mgoral7 Eleven2014-10-26Not AvailableUs
Refenesensyrup200 mg/5mLoralReese Pharmaceutical Co.2014-05-15Not AvailableUs
Refenesen Chest Congestion Relieftablet400 mgoralReese Pharmaceutical Co2003-09-23Not AvailableUs
Mucus Relieftablet400 mgoralTarget Corporation2013-11-30Not AvailableUs
Mucus Relieftablet, film coated400 mgoralTarget Corporation2005-12-22Not AvailableUs
Adult Tussinsyrup100 mg/5mLoralRite Aid Corporation2013-09-21Not AvailableUs
Tussin Originalliquid100 mg/5mLoralRite Aid2009-07-16Not AvailableUs
Tussin Originalliquid100 mg/5mLoralRite Aid2009-08-11Not AvailableUs
Mucus Relieftablet, extended release600 mgoralRite Aid Corporation2013-03-20Not AvailableUs
Mucus Relief Chesttablet, coated400 mgoralRite Aid2005-12-22Not AvailableUs
Select Brand Mucus Relieftablet200 mgoralSelect Brand Distributors2014-09-26Not AvailableUs
Select Brand Coughtab 400tablet400 mgoralSelect Brand Distributors2012-08-01Not AvailableUs
Select Brand Tab Tussintablet400 mgoralSelect Brand Distributors2012-08-01Not AvailableUs
Tussin Originalliquid100 mg/5mLoralSelect Brand2009-06-17Not AvailableUs
Tussin Originalliquid100 mg/5mLoralSelect Brand2009-07-14Not AvailableUs
Respaire-30capsule150; 30 mg/1; mgoralLaser Pharmaceuticals, LLC2008-09-02Not AvailableUs
Mucinextablet, extended release600 mgoralAtlantic Biologicals Corps2012-07-03Not AvailableUs
Mucus Ertablet, extended release600 mgoralSafeway2013-07-25Not AvailableUs
Mucus Relieftablet, extended release600 mgoralSafeway2013-07-25Not AvailableUs
Mucus Relieftablet400 mgoralSafeway2005-12-22Not AvailableUs
Organ-i Nrtablet200 mgoralRebel Distributors Corp2002-07-01Not AvailableUs
Coughliquid100 mg/5mLoralRebel Distributors Corp2009-12-04Not AvailableUs
Mucinextablet, extended release600 mgoralRebel Distributors Corp2009-03-27Not AvailableUs
Childrens Mucus Relief Expectorant Grapeliquid100 mg/5mLoralGood Neighbor Pharmacy2009-07-20Not AvailableUs
Good Neighbor Pharmacy Tussinsyrup100 mg/5mLoralAmerisource Bergen1989-08-15Not AvailableUs
Good Neighbor Pharmacy Mucus Relieftablet400 mgoralAmerisource Bergen Drug Corp2011-09-15Not AvailableUs
Bidex-400tablet400 mgoralSJ Pharmaceuticals2012-11-09Not AvailableUs
Mucus Relieftablet400 mgoralThe Kroger Co.2010-07-06Not AvailableUs
Tussin adults non drowsysyrup200 mg/10mLoralKroger Company1991-12-12Not AvailableUs
Mucus Ertablet, extended release600 mgoralKroger Company2013-03-18Not AvailableUs
Mucus Relief Expectoranttablet400 mgoralASSURED / DOLLAR TREE (Greenbrier International, Inc.)2013-04-16Not AvailableUs
Coughliquid100 mg/5mLoralLake Erie Medical DBA Quality Care Products LLC2009-12-04Not AvailableUs
Topcare Mucus Reliefliquid100 mg/5mLoralTopco Associates LLC2007-11-01Not AvailableUs
Topcare Tussin Chest Congestionsyrup100 mg/5mLoralTopco Associates LLC1990-01-15Not AvailableUs
Topcare Mucus Ertablet, extended release600 mgoralTopco Associates LLC2013-03-18Not AvailableUs
Topcare Tussin mucus plus chest congestionsyrup200 mg/10mLoralTopco Associates LLC1990-01-15Not AvailableUs
Shopko Chest Congestion Relieftablet400 mgoralShopko2012-08-01Not AvailableUs
Mucus Ertablet, extended release600 mgoralShopko Stores Operating Co., LLC2013-07-08Not AvailableUs
Leader Cough Tabstablet200 mgoralCardinal Health2005-03-01Not AvailableUs
Leader Chest Congestion Relief G450tablet400 mgoralCardinal Health2005-03-01Not AvailableUs
Leader Mucus Ertablet, extended release600 mgoralCardinal Health2013-03-19Not AvailableUs
Leader Tabtussin 400tablet400 mgoralCardinal Health2012-08-01Not AvailableUs
Leader Tabtussin 400tablet400 mgoralCardinal Health2012-08-01Not AvailableUs
Leader Adult Tussin Chest Congestionsyrup100 mg/5mLoralCardinal Health1990-04-15Not AvailableUs
Leader Mucus Relief childrensliquid100 mg/5mLoralCardinal Health2007-10-26Not AvailableUs
Childrens Mucus Reliefliquid100 mg/5mLoralH E B2009-01-05Not AvailableUs
Rx Act Tussin Chest Congestionsyrup100 mg/5mLoralH E B1997-05-08Not AvailableUs
Mucus Relieftablet, extended release600 mgoralH E B2013-03-19Not AvailableUs
Equaline Tussin chest congestionsyrup100 mg/5mLoralSupervalu Inc2004-10-01Not AvailableUs
Equaline Mucus Ertablet, extended release600 mgoralSupervalu Inc2013-08-06Not AvailableUs
Shoprite Adult Tussinsyrup200 mg/10mLoralWakefern Food Corporation2014-05-12Not AvailableUs
Shoprite Mucus Relieftablet, extended release600 mgoralWakefern Food Corporation2013-08-26Not AvailableUs
Coughsyrup100 mg/5mLoralMeijer Distribution Inc1987-08-15Not AvailableUs
Mucus Relieftablet, extended release600 mgoralMeijer Distribution Inc2013-03-18Not AvailableUs
Tussin Chest Congestion Adult Non Drowsysyrup100 mg/5mLoralHannaford Brothers Company2005-09-05Not AvailableUs
Careone Mucus Relief childrensliquid100 mg/5mLoralAmerican Sales Company2007-08-08Not AvailableUs
Careone Adult Tussinsyrup200 mg/10mLoralAmerican Sales Company2004-05-04Not AvailableUs
Careone Mucus Ertablet, extended release600 mgoralAmerican Sales Company2013-04-21Not AvailableUs
Ultra Tusssyrup100 mg/5mLoralUltra Seal Corporation2012-06-19Not AvailableUs
Guaifenesintablet400 mgoralAv Kare, Inc.2012-05-16Not AvailableUs
Guaifenesintablet200 mgoralAv Kare, Inc.2013-11-04Not AvailableUs
Adult Tussin chest congestionsyrup100 mg/5mLoralHy Vee Inc1997-06-25Not AvailableUs
Mucus Ertablet, extended release600 mgoralHy Vee Inc2013-03-18Not AvailableUs
Chest Congestionliquid100 mg/5mLoralAccudial Pharmaceutical, Inc.2009-10-26Not AvailableUs
Chest Congestionsolution100 mg/5mLoralAccudial Pharmaceutical, Inc.2013-02-01Not AvailableUs
Guaifenesin Extended Releasetablet, extended release600 mgoralPerrigo New York Inc2012-03-28Not AvailableUs
Guaapliquid100 mg/5mLoralA P J Laboratories Limited2013-03-01Not AvailableUs
Good Neighbor Pharmacy Mucus Ertablet, extended release600 mgoralAmerisource Bergen2013-03-19Not AvailableUs
Good Neighbor Pharmacy Tabtussintablet400 mgoralAmerisource Bergen Drug Corp2011-09-26Not AvailableUs
Good Neighbor Pharmacy Tussinsyrup200 mg/10mLoralAmerisource Bergen2014-10-22Not AvailableUs
Equate Tussin Adult Chest Congestionsyrup100 mg/5mLoralWal Mart Stores Inc2000-07-25Not AvailableUs
Equate Mucus Ertablet, extended release600 mgoralWal Mart Stores Inc2013-03-22Not AvailableUs
Mucus Relief Chesttablet400 mgoralWal Mart Stores Inc2005-12-22Not AvailableUs
Sunmark Tussinsyrup200 mg/10mLoralMc Kesson2014-09-17Not AvailableUs
Sunmark Tussin chest congestionsyrup100 mg/5mLoralMc Kesson2003-07-03Not AvailableUs
Chest Congestion Relieftablet400 mgoralMcKesson2012-08-01Not AvailableUs
Sunmark Mucus Ertablet, extended release600 mgoralMc Kesson2013-03-18Not AvailableUs
Mucosatablet400 mgoralTIME CAP LABORATORIES, INC2012-04-16Not AvailableUs
Tussin Originalliquid100 mg/5mLoralAaron Industries, Inc.2009-01-16Not AvailableUs
Tussin Originalliquid100 mg/5mLoralAaron Industries, Inc.2009-01-16Not AvailableUs
Tussin Adult chest congestionsyrup100 mg/5mLoralMedicine Shoppe International Inc1992-11-03Not AvailableUs
The Medicine Shoppe Chest Congestion Relieftablet400 mgoralMedicine Shoppe International Inc2005-03-01Not AvailableUs
Smart Sense Childrens Mucus Reliefliquid100 mg/5mLoralKmart Corporation2010-12-03Not AvailableUs
Smart Sense Tussin adultsyrup200 mg/10mLoralKmart Corporation2011-01-17Not AvailableUs
Smart Sense Mucus Ertablet, extended release600 mgoralKmart Corporation2013-08-05Not AvailableUs
Selecthealth Tussin Dmliquid100 mg/5mLoralAxcentria Pharmaceuticals, LLC.2011-09-01Not AvailableUs
Leader Adult Tussin Mucus Plus Chest Congestionsyrup200 mg/10mLoralCardinal Health1990-04-15Not AvailableUs
Guiatusssyrup100 mg/5mLoralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-03-12Not AvailableUs
Guaifenesinsolution100 mg/5mLoralHi Tech Pharmacal Co., Inc.2012-03-07Not AvailableUs
Mucus Releif Expectoranttablet400 mgoralGood Sense (Geiss, Destin & Dunn, Inc.)2013-04-30Not AvailableUs
Mucus Relieftablet, film coated400 mgoralL.N.K. International, Inc.1995-12-22Not AvailableUs
Broncomar SFliquid100 mg/5mLoralGadal Laboratories Inc2014-06-01Not AvailableUs
Gadavyt Coughliquid100 mg/5mLoralGadal Laboratories Inc2012-12-01Not AvailableUs
Robafen Cough Formulasyrup100 mg/5mLoralAidarex Pharmaceuticals LLC2012-08-15Not AvailableUs
Ritussin Expectorantliquid100 mg/5mLoralRij Pharmaceutical Corporation1999-03-16Not AvailableUs
Mucinextablet, extended release600 mgoralState of Florida DOH Central Pharmacy2013-01-01Not AvailableUs
Siltussin Saliquid100 mg/5mLoralSilarx Pharmaceuticals, Inc1998-10-05Not AvailableUs
Siltussin Dasliquid100 mg/5mLoralSilarx Pharmaceuticals, Inc1996-02-01Not AvailableUs
Diabetic Siltussin Das-naliquid100 mg/5mLoralSilarx Pharmaceuticals, Inc2005-12-05Not AvailableUs
Mucinextablet, extended release600 mgoralPhysicians Total Care, Inc.2003-03-05Not AvailableUs
Guaifenesintablet200 mgoralPhysicians Total Care, Inc.2008-01-07Not AvailableUs
Mucinextablet, extended release600 mgoralDispensing Solutions, Inc.2010-05-12Not AvailableUs
Mucinextablet, extended release600 mgoralCardinal Health2009-03-27Not AvailableUs
Mucinextablet, extended release600 mgoralCardinal Health2010-07-22Not AvailableUs
Pancold Sliquid300; 30; 2.5; 83.3; 17.5 mg/30mL; mg/30mL; mg/30mL; mg/30mL; mg/30mLoralKafus Co., Ltd2013-01-15Not AvailableUs
Expectoranttablet400 mgoralWestern Family Foods, Inc.2010-07-01Not AvailableUs
Tussin adult chest congestionsyrup200 mg/10mLoralWestern Family Foods Inc2000-04-10Not AvailableUs
Expectorant 12 Hourtablet, extended release600 mgoralWestern Family Foods Inc2013-03-25Not AvailableUs
Childrensrelief Expectorant Grapeliquid100 mg/5mLoralFood Lion2009-09-23Not AvailableUs
Healthy Accents Childrens Mucus Reliefliquid100 mg/5mLoralDZA Brands LLC2013-07-10Not AvailableUs
Healthy Accents Tussin Chest Congestion adultsyrup100 mg/5mLoralDZA Brands LLC2008-01-29Not AvailableUs
Healthy Accents Tussinsyrup200 mg/10mLoralDZA Brands LLC2014-07-09Not AvailableUs
Healthy Accents Mucus Relieftablet, extended release600 mgoralDZA Brands LLC2014-10-30Not AvailableUs
Mucus Relieftablet400 mgoralFamily Dollar (FAMILY WELLNESS)2014-07-31Not AvailableUs
Mucus Relieftablet400 mgoralFamily Dollar2005-12-22Not AvailableUs
Dg Health Mucus Relief Ertablet, extended release600 mgoralDolgencorp, LLC2013-05-17Not AvailableUs
Childrens Mucus Reliefliquid100 mg/5mLoralPublix Super Markets Inc2012-12-14Not AvailableUs
Tussin expectorant for adultssyrup200 mg/10mLoralPublix Super Markets Inc2004-02-13Not AvailableUs
Mucus Ertablet, extended release600 mgoralPublix Super Markets Inc2013-03-25Not AvailableUs
Geri-tussin Expectorantliquid100 mg/5mLoralGeri Care Pharmaceuticals, Corp2000-01-01Not AvailableUs
Mucus Relieftablet400 mgoralGeri Care Pharmaceuticals, Corp2004-01-01Not AvailableUs
Mucus Relieftablet400 mgoralClinical Solutions Wholesale2012-07-23Not AvailableUs
Rompe Pecholiquid100 mg/5mLoralEfficient Laboratories Inc1998-01-01Not AvailableUs
Cough Outliquid100 mg/5mLoralEfficient Laboratories Inc.1997-07-01Not AvailableUs
Rompe Pecho SFliquid100 mg/5mLoralEfficient Laboratories, Inc.1999-03-01Not AvailableUs
Rompe Pecho EXliquid100 mg/5mLoralEfficient Laboratories Inc2015-01-01Not AvailableUs
Mucus Relieftablet400 mgoralP And L Development Of New York Corporation (Ready In Case)2012-12-07Not AvailableUs
Tussinsolution100 mg/5mLoralBio Pharm, Inc.2014-04-08Not AvailableUs
Chest Congestionsolution100 mg/5mLoralBio Pharm, Inc.2014-05-16Not AvailableUs
Chest Congestion childrensliquid100 mg/5mLoralCVS Pharmacy2009-03-11Not AvailableUs
Tussin Originalliquid100 mg/5mLoralCVS2009-07-16Not AvailableUs
Mucus Extended Releasetablet, extended release600 mgoralCVS Pharmacy2013-03-19Not AvailableUs
Tussin adult chest congestionsyrup200 mg/10mLoralCVS Pharmacy1987-07-15Not AvailableUs
Air Powertablet200 mgoralEnzymatic Therapy, LLC2003-05-19Not AvailableUs
Mucaplextablet200 mgoralEnzymatic Therapy, LLC2005-10-01Not AvailableUs
Preferred Plus Chest Congestion Relieftablet400 mgoralKinray2012-08-01Not AvailableUs
Preferred Plus Tabtussintablet400 mgoralKinray2011-09-26Not AvailableUs
Preferred Plus Mucus Ertablet, extended release600 mgoralKinray2014-10-13Not AvailableUs
Diabetic Tussin Expectorantliquid100 mg/5mLoralHealth Care Products1996-01-01Not AvailableUs
Diabetic Tussin Mucus Relieftablet400 mgoralHealth Care Products2001-08-012015-02-28Us
Kids-eeze Chest Relieftablet, orally disintegrating100 mgoralPro Phase Labs, Inc.2008-09-01Not AvailableUs
Healthmart Chest Congestion Relieftablet400 mgoralMcKesson2012-08-01Not AvailableUs
Health Mart Mucus Ertablet, extended release600 mgoralMc Kesson2013-03-19Not AvailableUs
Health Mart Adult Tussinsyrup200 mg/10mLoralMc Kesson2012-01-11Not AvailableUs
Little Remedies Little Colds Mucus Relief Expectorant Melt Awaysgranule100 mgoralMedtech Products Inc.2009-12-31Not AvailableUs
Mucus Relieftablet400 mgoralAvema Pharma Solutions2011-01-18Not AvailableUs
Mucinextablet, extended release600 mgoralReckitt Benckiser LLC2012-07-03Not AvailableUs
Mucinex Maximum Strengthtablet, extended release1200 mgoralReckitt Benckiser LLC2012-06-26Not AvailableUs
Mucinex For Kidsgranule50 mgoralReckitt Benckiser, Inc.2009-03-24Not AvailableUs
Childrens Mucinex Mini-Melts Chest Congestiongranule100 mgoralReckitt Benckiser2009-03-24Not AvailableUs
Mucinex for Kidssolution100 mg/5mLoralReckitt Benckiser, Inc.2009-04-08Not AvailableUs
Childrens Mucinex Chest Congestionliquid100 mg/5mLoralReckitt Benckiser LLC2011-07-01Not AvailableUs
Childrens Mucinex Chest Congestionsolution100 mg/5mLoralReckitt Benckiser LLC2012-07-13Not AvailableUs
Childrens Mucinex Chest Congestionsolution100 mg/5mLoralReckitt Benckiser, Inc.2010-06-22Not AvailableUs
Tussin Non Drowsyliquid100 mg/5mLoralQUALITY CHOICE (Chain Drug Marketing Association)2014-06-30Not AvailableUs
Quality Choice Mucus Relieftablet400 mgoralChain Drug Marketing Association2012-08-01Not AvailableUs
Mucus Relieftablet, film coated400 mgoralCostco Wholesale Corporation2005-12-22Not AvailableUs
Liquituss Ggliquid200 mg/5mLoralCapellon Pharmaceuticals, LLC2012-06-15Not AvailableUs
Guaifenesintablet200 mgoralContract Pharmacy Services Pa2011-01-27Not AvailableUs
Tussin Chest Congestion Non Drowsyliquid100 mg/5mLoralWin Co Foods, Llc2014-12-31Not AvailableUs
Tussin Chestliquid100 mg/5mLoralKareway Product, Inc.2011-08-29Not AvailableUs
Premier Value Chest Congestion Relieftablet400 mgoralPremier Value2009-05-04Not AvailableUs
Tussin EXPECTORANTliquid100 mg/5mLoralChain Drug Consortium, LLC2012-09-07Not AvailableUs
Childrens Chest Congestion Reliefliquid100 mg/5mLoralChain Drug Consortium, LLC2012-09-01Not AvailableUs
Mucus Relief Immediate Releasetablet400 mgoralChain Drug Consortium2014-12-29Not AvailableUs
Organ-i Nrtablet200 mgoralAmerican Health Packaging2014-07-31Not AvailableUs
Organ-i Nrtablet200 mgoralCarilion Materials Management2002-07-01Not AvailableUs
Simply Right Mucus Relieftablet, extended release600 mgoralSam's West Inc2013-08-20Not AvailableUs
Mucus Relieftablet400 mgoralSam's West Inc2005-12-22Not AvailableUs
Licorice Coughing Liquidliquid5 g/100mLoralMayinglong Pharmaceutical Group Co., Ltd2003-12-15Not AvailableUs
Diabetic Siltussin Das-naliquid100 mg/5mLoralPreferred Pharmaceuticals Inc.2012-07-24Not AvailableUs
Q-tussinsolution100 mg/5mLoralPreferred Pharmaceuticals, Inc1997-10-01Not AvailableUs
Siltussin Saliquid100 mg/5mLoralPreferred Pharmaceuticals, Inc1998-10-05Not AvailableUs
Mucus Relief Immediate Releasetablet400 mgoralAllegiant Health2014-12-23Not AvailableUs
Tussin Originalliquid100 mg/5mLoralNash Finch Company2009-03-20Not AvailableUs
Mucus Relieftablet, film coated400 mgoralNash Finch Company2005-12-22Not AvailableUs
Liqufrutasyrup50 mg/5mLoralAlston Garrard & Co2011-01-01Not AvailableUs
Liqufrutasyrup50 mg/5mLoralAlston Garrard & Co2011-01-01Not AvailableUs
Simpex Guaifenesintablet400 mgoralSimpex Pharma Pvt. Ltd2013-11-07Not AvailableUs
International Brands
NameCompany
Duratuss GNot Available
GanidinCypress
HustosilKyoto Yakuhin
HytussHyrex
RobitussinWyeth
Scot-tussin ExpectorantNot Available
Sinumist-SRNot Available
Brand mixtures
Brand NameIngredients
Babys Own Cough SyrAmmonium Chloride + Guaifenesin + Pyrilamine Maleate
Benylin 4 Flu - SyrupAcetaminophen + Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride
Benylin Codeine 3.3mg de SyrCodeine Phosphate + Guaifenesin + Pseudoephedrine Hydrochloride
BiocotronDextromethorphan + Guaifenesin
Broncho Tuss AdultGuaifenesin + L-Ephedrine Hydrochloride + Sodium Camsylate
Broncho Tuss InfantGuaifenesin + L-Ephedrine Hydrochloride + Sodium Camsylate
Bronchodex PediatriqueDextromethorphan Hydrobromide + Guaifenesin + Pheniramine Maleate + Pseudoephedrine Hydrochloride
Calmylin #3 SyrDextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride
Calmylin Codeine D-E SyrCodeine Phosphate + Guaifenesin + Pseudoephedrine Hydrochloride
Calmylin Cough and Flu LiqAcetaminophen + Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride
Centracol Pediatrique - SyrDextromethorphan Hydrobromide + Guaifenesin + Pheniramine Maleate + Pseudoephedrine Hydrochloride
Cheracol Cough SyrupAlcohol Anhydrous + Ammonium Chloride + Codeine Phosphate + Guaifenesin
Cold Aid for BirdsAmmonium Chloride + Glycerine + Guaifenesin + Oil of Anise + Sodium Bicarbonate
Cold and Respiratory Aid for HamstersAmmonium Chloride + Glycerine + Guaifenesin + Oil of Anise + Sodium Bicarbonate
Cough and Flu SyrupAcetaminophen + Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride
Cough Syr W.Cod. Pseudoephed.Hcl GuaifenesinCodeine Phosphate + Guaifenesin + Pseudoephedrine Hydrochloride
Cough Syrup Dm Decongestant ExpectorantDextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride
Cough Syrup Dm ExpectorantDextromethorphan Hydrobromide + Guaifenesin
Cough Syrup Dm-D-EDextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride
Cough Syrup Dm-EDextromethorphan Hydrobromide + Guaifenesin
Cough Syrup Dm-ExpectorantDextromethorphan Hydrobromide + Guaifenesin
Cough Syrup W.Guaifenesin W.DextromethorphanDextromethorphan Hydrobromide + Guaifenesin
Creo Grippe Enfants SupCamphor + Eucalyptol + Guaifenesin
Creo Grippe Sup AdultesCamphor + Eucalyptol + Guaifenesin
Dayquil LiquicapsAcetaminophen + Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride
Daytime Cold & Flu Liquid CapsulesAcetaminophen + Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride
Daytime Liquid - LiqAcetaminophen + Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride
Dimetane Expectorant LiqBrompheniramine Maleate + Guaifenesin + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride
Dimetane Expectorant-C SyrBrompheniramine Maleate + Codeine Phosphate + Guaifenesin + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride
Dimetane Expectorant-Dc SyrBrompheniramine Maleate + Guaifenesin + Hydrocodone Bitartrate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride
Dm Cough Syrup ExpectorantDextromethorphan Hydrobromide + Guaifenesin
Dm Expectorant Cough SyrupDextromethorphan Hydrobromide + Guaifenesin
Dm Plus Decongestant Plus Expector.Ex.St.SyrDextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride
Dm Plus Decongestant Plus Expectorant Cough SyrupDextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride
Dm Plus Expectorant SyrupDextromethorphan Hydrobromide + Guaifenesin
Dm-D-Expectorant Cough and Cold SyrupDextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride
Dymetadrine 25 - TabEphedrine Hydrochloride + Guaifenesin
Entex LaGuaifenesin + Phenylpropanolamine Hydrochloride
Entex La Tablets SrtGuaifenesin + Phenylpropanolamine Hydrochloride
Ephedrine Ii with GuaifenesinEphedrine Racemic (Ephedrine Hydrochloride) + Guaifenesin
Ephedrine V with GuaifenesinEphedrine Hydrochloride + Guaifenesin
Guaiacol Plus PwrAmmonium Chloride + Guaifenesin + Potassium Iodide
I D M Expectorant TabGuaifenesin + Potassium Iodide + Pyrilamine Maleate + Theophylline
I.D.M. SolutionGuaifenesin + L-Ephedrine Hydrochloride + Potassium Iodide + Pyrilamine Maleate
Koffex Dm + Decongestant + ExpectorantDextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride
Koffex Dm + Decongestant + Expectorant Extra StrengthDextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride
Koffex Dm + ExpectorantDextromethorphan Hydrobromide + Guaifenesin
Koffex Dm + Expectorant Extra StrengthDextromethorphan Hydrobromide + Guaifenesin
Koffex Dm-D-E - LiqDextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride
Mielocol SyrupAralia Racemosa + Eucalyptol + Guaifenesin + Honey + Poplar Bud + Sanguinaria Canadensis + White Pine + Wild Cherry
Nezger TabAcetylsalicylic Acid + Diphenylpyraline Hydrochloride + Guaifenesin + Phenylephrine Hydrochloride
Novahistex Dh ExpectorantGuaifenesin + Hydrocodone Bitartrate + Phenylephrine Hydrochloride
Novahistex Dm Expectorant with DecongestantDextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride
Novahistex Expectorant with DecongestantGuaifenesin + Pseudoephedrine Hydrochloride
Novahistine Dm Expectorant with DecongestantDextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride
Ornade Expectorant Cough FormulaChlorpheniramine Maleate + Guaifenesin + Phenylpropanolamine Hydrochloride
Pharmitussin DmDextromethorphan Hydrobromide + Guaifenesin
Pulmorex Expectorant LiqAmmonium Chloride + Diphenhydramine Hydrochloride + Guaifenesin
Pulmosirum Plus ExpectorantAmmonium Chloride + Beechwood Creosote + Cocillana + Eucalyptus Oil + Guaiacol + Guaifenesin + Ipecac + Lobelia Inflata + Menthol + Myroxylon Balsamum + White Pine
Quiex-K1 SyrAminophylline + Guaifenesin + Potassium Iodide
Regular Strength Tylenol Cold Chest CongestionAcetaminophen + Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride
Robitussin Syrup with CodeineCodeine Phosphate + Guaifenesin + Pheniramine Maleate
Sudafed Cold and Flu Gel CapsAcetaminophen + Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride
Tri-Anamine Expect Antihist Decong SyrupGuaifenesin + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate
Triaminic Decongest+Expect Liqui-Gels CapGuaifenesin + Pseudoephedrine Hydrochloride
Triaminic DM Daytime SyrDextromethorphan Hydrobromide + Guaifenesin + Phenylpropanolamine Hydrochloride
Triaminic DM Expectorant SyrChlorpheniramine Maleate + Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride
Triaminic Expectorant Dh SyrupGuaifenesin + Hydrocodone Bitartrate + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate
Triaminic Expectorant SyrChlorpheniramine Maleate + Guaifenesin + Pseudoephedrine Hydrochloride
Tussin Cough Medicine Dm Antitussive Expectorant DecongestantDextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride
Vicks Cough Syrup New ImprovedCarbetapentane Citrate + Ephedrine + Guaifenesin
SaltsNot Available
Categories
CAS number93-14-1
WeightAverage: 198.2158
Monoisotopic: 198.089208936
Chemical FormulaC10H14O4
InChI KeyHSRJKNPTNIJEKV-UHFFFAOYSA-N
InChI
InChI=1S/C10H14O4/c1-13-9-4-2-3-5-10(9)14-7-8(12)6-11/h2-5,8,11-12H,6-7H2,1H3
IUPAC Name
3-(2-methoxyphenoxy)propane-1,2-diol
SMILES
COC1=CC=CC=C1OCC(O)CO
Mass Specshow(7.98 KB)
Taxonomy
KingdomOrganic Compounds
SuperclassBenzenoids
ClassBenzene and Substituted Derivatives
SubclassPhenol Ethers
Direct parentAnisoles
Alternative parentsAlkyl Aryl Ethers; Secondary Alcohols; 1,2-Diols; Primary Alcohols; Polyamines
Substituentsalkyl aryl ether; secondary alcohol; polyol; 1,2-diol; primary alcohol; ether; polyamine; alcohol
Classification descriptionThis compound belongs to the anisoles. These are organic compounds contaiing a methoxybenzene or a derivative thereof.
Pharmacology
IndicationUsed to assist the expectoration of phlegm from the airways in acute respiratory tract infections.
PharmacodynamicsGuaifenesin is an expectorant which increases the output of phlegm (sputum) and bronchial secretions by reducing adhesiveness and surface tension. The increased flow of less viscous secretions promotes ciliary action and changes a dry, unproductive cough to one that is more productive and less frequent. By reducing the viscosity and adhesiveness of secretions, guaifenesin increases the efficacy of the mucociliary mechanism in removing accumulated secretions from the upper and lower airway.
Mechanism of actionGuaifenesin may act as an irritant to gastric vagal receptors, and recruit efferent parasympathetic reflexes that cause glandular exocytosis of a less viscous mucus mixture. Cough may be provoked. This combination may flush tenacious, congealed mucopurulent material from obstructed small airways and lead to a temporary improvement in dyspnea or the work of breathing.
AbsorptionRapidly absorbed from the GI tract
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Rapidly hydrolyzed (60% within seven hours) and then excreted in the urine, with beta-(2-methoxyphenoxy)-lactic acid as its major urinary metabolite.

SubstrateEnzymesProduct
Guaifenesin
Not Available
beta-(2-methoxyphenoxy)-lactic acidDetails
Route of eliminationNot Available
Half life1 hour
ClearanceNot Available
ToxicityLD50 1510 mg/kg (rat, oral)
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
Property Value Probability
Human Intestinal Absorption + 0.9231
Blood Brain Barrier - 0.8631
Caco-2 permeable - 0.6755
P-glycoprotein substrate Substrate 0.5523
P-glycoprotein inhibitor I Non-inhibitor 0.7979
P-glycoprotein inhibitor II Non-inhibitor 0.9002
Renal organic cation transporter Non-inhibitor 0.88
CYP450 2C9 substrate Non-substrate 0.8348
CYP450 2D6 substrate Non-substrate 0.8535
CYP450 3A4 substrate Non-substrate 0.6853
CYP450 1A2 substrate Inhibitor 0.6013
CYP450 2C9 substrate Non-inhibitor 0.9592
CYP450 2D6 substrate Non-inhibitor 0.9616
CYP450 2C19 substrate Non-inhibitor 0.9328
CYP450 3A4 substrate Non-inhibitor 0.9481
CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.9445
Ames test Non AMES toxic 0.7677
Carcinogenicity Non-carcinogens 0.9215
Biodegradation Ready biodegradable 0.7769
Rat acute toxicity 2.0868 LD50, mol/kg Not applicable
hERG inhibition (predictor I) Weak inhibitor 0.9171
hERG inhibition (predictor II) Non-inhibitor 0.8735
Pharmacoeconomics
Manufacturers
  • Reckitt benckiser inc
Packagers
Dosage forms
FormRouteStrength
Capsuleoral150; 30 mg/1; mg
Granuleoral100 mg
Granuleoral50 mg
Liquidoral100 mg/5mL
Liquidoral200 mg/5mL
Liquidoral300; 30; 2.5; 83.3; 17.5 mg/30mL; mg/30mL; mg/30mL; mg/30mL; mg/30mL
Liquidoral5 g/100mL
Solutionoral100 mg/5mL
Syruporal100 mg/5mL
Syruporal200 mg/10mL
Syruporal200 mg/5mL
Syruporal50 mg/5mL
Tabletoral200 mg
Tabletoral400 mg
Tablet, coatedoral400 mg
Tablet, extended releaseoral1200 mg
Tablet, extended releaseoral600 mg
Tablet, film coatedoral400 mg
Tablet, orally disintegratingoral100 mg
Prices
Unit descriptionCostUnit
Diabetic Tussin Max St 10-200 mg/5ml Liquid 118ml Bottle15.99USDbottle
Naldecon Senior EX 200 mg/5ml Syrup 118ml Bottle15.99USDbottle
P-ephed w/guaifen tablet1.21USDtablet
P-ephedrine-guaifen la tablet1.14USDtablet
Guaifen/p-ephed tablet sa1.01USDtablet
Organidin nr 200 mg tablet0.89USDtablet
Mucinex dm er 1200-60 mg tablet0.8USDtablet
Pseudoephedrine-guaifen tr tablet0.76USDtablet
Humibid e 400 mg tablet0.74USDtablet
Mucinex d er tablet0.73USDtablet
P-ephed w/guaifen tablet sr0.67USDtablet
Pseudoephedrine-guaif sr tablet0.63USDtablet
Guaifenesin/p-ephedrine tablet0.62USDtablet
P-ephed-guaifen tablet la0.6USDtablet
Kid's mucinex mini-melts pack0.57USDeach
Mucinex cough mini-melt pack0.57USDeach
Mucinex d tablet0.54USDtablet
Organidin NR 100 mg/5ml Liquid0.49USDml
Codeine 10 mg-guai 300 mg liq0.46USDml
Mucinex er 600 mg tablet0.44USDtablet
Mucinex 600 mg tablet0.42USDtablet
Mucinex full force nasal spray0.42USDml
Mucinex moisture smart nas spr0.42USDml
Tussi-Organidin NR 300-10 mg/5ml Liquid0.39USDml
Mucus relief 400 mg tablet0.37USDtablet
Codeine-guaifen 10 mg-200 mg liq0.28USDml
Guaifenesin 200 mg tablet0.28USDtablet
Guaifenesin-dm 400-20 mg tablet0.25USDtablet
Robitussin coughgels0.25USDeach
Diabetic tussin ex 400 tablet0.2USDtablet
G-fenesin dm 20-400 mg caplet0.2USDcaplet
Organ-i nr 200 mg tablet0.2USDtablet
G-fenesin 400 mg caplet0.19USDcaplet
Guaifenesin 400 mg tablet0.16USDtablet
Chest congestion relief tablet0.15USDtablet
Guaifen p-ephed caplet er0.15USDcaplet
Fenesin dm ir tablet0.13USDtablet
Fenesin pe ir tablet0.13USDtablet
Guaifenesin nr liquid0.13USDml
Fenesin ir 400 mg tablet0.1USDtablet
Guaifenesin-dm nr liquid0.1USDml
Guaifenesin-DM 100-10 mg/5ml Liquid0.09USDml
Robitussin dm to go liquid0.09USDml
Guaiacol liquid purified0.08USDml
Guaifenesin dac oral solution0.08USDml
Guaifenesin nr 100 mg/5 ml0.08USDml
Children's mucinex cough liq0.06USDml
Mucinex cold liquid0.06USDml
Naldecon-dx senior0.06USDml
Child's mucinex 100 mg/5 ml lq0.05USDml
Guiatuss-dm syrup0.05USDml
Adlt robitussin cough-cold-flu0.04USDml
Adt robitussin cough-cold d lq0.04USDml
Adult robitussin cough syrup0.04USDml
Guiatuss DAC 30-10-100 mg/5ml Solution0.04USDml
Robitussin chest congest syrup0.04USDml
Robitussin cough & cold liquid0.04USDml
Robitussin cough-cold liquid0.04USDml
Robitussin cough-cong syrup0.04USDml
Robitussin dm max liquid0.04USDml
Robitussin long-acting liq0.04USDml
Robitussin pe head & chest liq0.04USDml
Robitussin-cough-chest-cong lq0.04USDml
Robitussin-dm cough syrup0.04USDml
Scot-tussin 100 mg/5 ml liq0.04USDml
Guiatuss ac syrup0.03USDml
Guiatuss-dac syrup0.03USDml
Sb cough control syrup0.03USDml
Guaifenesin ac cough syrup0.02USDml
Guaifenesin dm syrup0.02USDml
Guiatuss dm syrup0.02USDml
Guiatuss-pe syrup0.02USDml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
CountryPatent NumberApprovedExpires (estimated)
United States63722522000-04-282020-04-28
Properties
Statesolid
Experimental Properties
PropertyValueSource
melting point78.5-79British Patent 628,497.
boiling point215 °C at 1.90E+01 mm HgPhysProp
water solubility5E+004 mg/L (at 25 °C)MERCK INDEX (1996)
logP1.39SMITH,JT & VINJAMOORI,DT (1995)
Predicted Properties
PropertyValueSource
Water Solubility14.9ALOGPS
logP0.76ALOGPS
logP0.34ChemAxon
logS-1.1ALOGPS
pKa (Strongest Acidic)13.62ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area58.92 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity51.24 m3·mol-1ChemAxon
Polarizability20.59 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
Spectra1D NMR2D NMR
References
Synthesis Reference

Wilfred P. Shum, Harry Mazurek, Jian Chen, “Process for producing enantiomerically enriched guaifenesin.” U.S. Patent US5495052, issued August, 1949.

US5495052
General ReferenceNot Available
External Links
ResourceLink
KEGG DrugD00337
PubChem Compound3516
PubChem Substance46508004
ChemSpider3396
PharmGKBPA449818
RxListhttp://www.rxlist.com/cgi/generic2/guaifen.htm
Drugs.comhttp://www.drugs.com/guaifenesin.html
PDRhealthhttp://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/tus1463.shtml
WikipediaGuaifenesin
ATC CodesR05CA03
AHFS Codes
  • 48:16.00
PDB EntriesNot Available
FDA labelshow(394 KB)
MSDSshow(73.4 KB)
Interactions
Drug InteractionsNot Available
Food InteractionsNot Available
Comments
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Drug created on June 13, 2005 07:24 / Updated on September 16, 2013 17:12