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Identification
NameTelithromycin
Accession NumberDB00976  (APRD00483)
TypeSmall Molecule
GroupsApproved
DescriptionTelithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with bacterial protein synthesis. Telithromycin binds to the 50S subunit of the 70S bacterial ribosome and blocks further peptide elongation. Binding occurs simultaneously at to two domains of 23S RNA of the 50S ribosomal subunit, domain II and V, where older macrolides bind only to one. It is used to treat mild to moderate respiratory infections.
Structure
Thumb
SynonymsNot Available
External Identifiers
  • HMR 3647
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ketektablet, film coated300 mg/1oralSanofi Aventis U.S. Llc2010-06-01Not applicableUs
Ketektablet, film coated400 mg/1oralSanofi Aventis U.S. Llc2010-06-01Not applicableUs
Ketektablet, film coated400 mg/1oralPhysicians Total Care, Inc.2004-10-27Not applicableUs
Ketektablet400 mgoralSanofi Aventis Canada Inc2003-05-292011-08-15Canada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIKI8H7H19WL
CAS number191114-48-4
WeightAverage: 812.018
Monoisotopic: 811.473143313
Chemical FormulaC43H65N5O10
InChI KeyLJVAJPDWBABPEJ-PNUFFHFMSA-N
InChI
InChI=1S/C43H65N5O10/c1-12-33-43(8)37(48(41(53)58-43)19-14-13-18-47-23-31(45-24-47)30-16-15-17-44-22-30)27(4)34(49)25(2)21-42(7,54-11)38(28(5)35(50)29(6)39(52)56-33)57-40-36(51)32(46(9)10)20-26(3)55-40/h15-17,22-29,32-33,36-38,40,51H,12-14,18-21H2,1-11H3/t25-,26-,27+,28+,29-,32+,33-,36-,37-,38-,40+,42-,43-/m1/s1
IUPAC Name
(3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-10-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-{4-[4-(pyridin-3-yl)-1H-imidazol-1-yl]butyl}-tetradecahydro-1H-oxacyclotetradeca[4,3-d][1,3]oxazole-2,6,8,14-tetrone
SMILES
[H][C@@]12[C@@H](C)C(=O)[[email protected]](C)C[C@@](C)(OC)[[email protected]](O[C@@H]3O[[email protected]](C)C[C@@H]([[email protected]]3O)N(C)C)[C@@H](C)C(=O)[C@@H](C)C(=O)O[[email protected]](CC)[C@@]1(C)OC(=O)N2CCCCN1C=NC(=C1)C1=CC=CN=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as aminoglycosides. These are molecules or a portion of a molecule composed of amino-modified sugars.
KingdomOrganic compounds
Super ClassOrganic oxygen compounds
ClassOrganooxygen compounds
Sub ClassCarbohydrates and carbohydrate conjugates
Direct ParentAminoglycosides
Alternative Parents
Substituents
  • Aminoglycoside core
  • N-substituted imidazole
  • Oxane
  • Oxazolidinone
  • Pyridine
  • 1,3-dicarbonyl compound
  • Azole
  • Cyclic alcohol
  • Imidazole
  • Oxazolidine
  • Heteroaromatic compound
  • Carbamic acid ester
  • 1,2-aminoalcohol
  • Carboxylic acid ester
  • Tertiary amine
  • Ketone
  • Lactone
  • Tertiary aliphatic amine
  • Cyclic ketone
  • Amino acid or derivatives
  • Secondary alcohol
  • Monocarboxylic acid or derivatives
  • Ether
  • Azacycle
  • Carboxylic acid derivative
  • Organoheterocyclic compound
  • Acetal
  • Oxacycle
  • Dialkyl ether
  • Amine
  • Carbonyl group
  • Alcohol
  • Organic oxide
  • Organic nitrogen compound
  • Organonitrogen compound
  • Hydrocarbon derivative
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor the treatment of Pneumococcal infection, acute sinusitis, acute bacterial tonsillitis, acute bronchitis and bronchiolitis, lower respiratory tract infection and lobar (pneumococcal) pneumonia.
PharmacodynamicsTelithromycin is a ketolide antibiotic which has an antimicrobial spectrum similar or slightly broader than that of penicillin. It is often used as an alternative in patients who have an allergy to penicillins. For respiratory tract infections, it has better coverage of atypical organisms, including mycoplasma. Telithromycin prevents bacterial growth by binding to bacterial 50S ribosomal subunits and interfering with bacterial peptide translocation and elongation.
Mechanism of actionTelithromycin acts by binding to domains II and V of 23S rRNA of the 50S ribosomal subunit. By binding at domain II, telithromycin retains activity against gram-positive cocci (e.g. Streptococcus pneumoniae) in the presence of resistance mediated by methylases (erm genes) that alter the binding site at domain V. Telithromycin may also inhibit the assembly of nascent ribosomal units. Compared to erythromycin A, telithromycin binds to the 23S rRNA with 10 times greater affinity in erythromycin-susceptible organisms and 25 times greater affinity in macrolide-resistant strains. This increased binding affinity may be conferred by the C11-12 carbamate side chain of telithromycin. The side chain appears to maintain binding at domain II in the presence of resistance mediated by alterations in domain V.
Related Articles
AbsorptionAbsolute bioavailability is approximately 57%. Maximal concentrations are reached 0.5 - 4 hours following oral administration. Food intake does not affected absorption.
Volume of distribution
  • 2.9 L/kg
Protein binding60 - 70% bound primarily to human serum albumin
Metabolism

Hepatic - estimated 50% metabolized by CYP3A4 and 50% metabolized independent of cytochrome P450

Route of eliminationThe systemically available telithromycin is eliminated by multiple pathways as follows: 7% of the dose is excreted unchanged in feces by biliary and/or intestinal secretion; 13% of the dose is excreted unchanged in urine by renal excretion; and 37% of the dose is metabolized by the liver.
Half lifeMain elimination half-life is 2-3 hours; terminal elimination half-life is 10 hours
ClearanceNot Available
ToxicityLD50>2000 mg/kg (PO in rats). Adverse effects are similar to those of clarithormycin and erithromycin and include diarrhea, nausea, vomiting, loose stools, abdominal pain, flatulence and dyspepsia. It may also cause dizziness, headache and taste disturbances.
Affected organisms
  • Enteric bacteria and other eubacteria
Pathways
PathwayCategorySMPDB ID
Telithromycin Action PathwayDrug actionSMP00252
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9904
Blood Brain Barrier-0.8608
Caco-2 permeable-0.8958
P-glycoprotein substrateSubstrate0.8472
P-glycoprotein inhibitor IInhibitor0.8737
P-glycoprotein inhibitor IIInhibitor0.7653
Renal organic cation transporterNon-inhibitor0.8479
CYP450 2C9 substrateNon-substrate0.7872
CYP450 2D6 substrateNon-substrate0.8617
CYP450 3A4 substrateSubstrate0.7538
CYP450 1A2 substrateNon-inhibitor0.8288
CYP450 2C9 inhibitorNon-inhibitor0.7157
CYP450 2D6 inhibitorNon-inhibitor0.8675
CYP450 2C19 inhibitorNon-inhibitor0.6476
CYP450 3A4 inhibitorNon-inhibitor0.8407
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7749
Ames testNon AMES toxic0.7687
CarcinogenicityNon-carcinogens0.8998
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.7843 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9399
hERG inhibition (predictor II)Non-inhibitor0.6053
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Tabletoral400 mg
Tablet, film coatedoral300 mg/1
Tablet, film coatedoral400 mg/1
Prices
Unit descriptionCostUnit
Ketek pak 400 mg tablet6.12USD tablet
Ketek 400 mg tablet5.87USD tablet
Ketek 300 mg tablet5.76USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2102457 No2002-01-222013-11-04Canada
CA2189271 No2005-12-272015-05-02Canada
US5635485 No1998-04-012018-04-01Us
USD459798 No1995-09-242015-09-24Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point176-188 °CNot Available
water solubility300 mg/LNot Available
logP3Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0283 mg/mLALOGPS
logP4.21ALOGPS
logP5.13ChemAxon
logS-4.5ALOGPS
pKa (Strongest Acidic)8.84ChemAxon
pKa (Strongest Basic)7.65ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count11ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area171.85 Å2ChemAxon
Rotatable Bond Count11ChemAxon
Refractivity214.68 m3·mol-1ChemAxon
Polarizability90.44 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

Suhas Sohani, Mandar Deodhar, Nishant Patel, Manish Patel, Mahesh Davadra, Vinodhamar Kansal, “Process for the Preparation of Telithromycin.” U.S. Patent US20070260066, issued November 08, 2007.

US20070260066
General References
  1. Clay KD, Hanson JS, Pope SD, Rissmiller RW, Purdum PP 3rd, Banks PM: Brief communication: severe hepatotoxicity of telithromycin: three case reports and literature review. Ann Intern Med. 2006 Mar 21;144(6):415-20. Epub 2006 Feb 15. [PubMed:16481451 ]
External Links
ATC CodesJ01FA15
AHFS Codes
  • 08:12.12.12
PDB EntriesNot Available
FDA labelDownload (1.6 MB)
MSDSDownload (201 KB)
Interactions
Drug Interactions
Drug
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be increased when it is combined with Telithromycin.
AbirateroneThe serum concentration of Telithromycin can be increased when it is combined with Abiraterone.
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Telithromycin.
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Telithromycin.
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Telithromycin.
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Telithromycin.
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Telithromycin.
AlclometasoneThe serum concentration of Alclometasone can be increased when it is combined with Telithromycin.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Telithromycin.
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Telithromycin.
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Telithromycin.
AlfuzosinAlfuzosin may increase the QTc-prolonging activities of Telithromycin.
AliskirenThe metabolism of Aliskiren can be decreased when combined with Telithromycin.
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Telithromycin.
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Telithromycin.
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Telithromycin.
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Telithromycin.
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Telithromycin.
AmantadineAmantadine may increase the QTc-prolonging activities of Telithromycin.
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Telithromycin.
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Telithromycin.
AmcinonideThe serum concentration of Amcinonide can be increased when it is combined with Telithromycin.
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Telithromycin.
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Telithromycin.
AmiodaroneTelithromycin may increase the QTc-prolonging activities of Amiodarone.
AmiodaroneThe metabolism of Telithromycin can be decreased when combined with Amiodarone.
AmitriptylineAmitriptyline may increase the QTc-prolonging activities of Telithromycin.
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Telithromycin.
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Telithromycin.
AmoxapineAmoxapine may increase the QTc-prolonging activities of Telithromycin.
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Telithromycin.
AnagrelideTelithromycin may increase the QTc-prolonging activities of Anagrelide.
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Telithromycin.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Telithromycin.
ApomorphineApomorphine may increase the QTc-prolonging activities of Telithromycin.
ApremilastThe metabolism of Apremilast can be decreased when combined with Telithromycin.
AprepitantThe serum concentration of Telithromycin can be increased when it is combined with Aprepitant.
AprepitantThe metabolism of Aprepitant can be decreased when combined with Telithromycin.
ArformoterolArformoterol may increase the QTc-prolonging activities of Telithromycin.
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Telithromycin.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Telithromycin.
AripiprazoleAripiprazole may increase the QTc-prolonging activities of Telithromycin.
Arsenic trioxideTelithromycin may increase the QTc-prolonging activities of Arsenic trioxide.
ArtemetherTelithromycin may increase the QTc-prolonging activities of Artemether.
AsenapineTelithromycin may increase the QTc-prolonging activities of Asenapine.
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Telithromycin.
AtazanavirAtazanavir may increase the QTc-prolonging activities of Telithromycin.
AtazanavirThe metabolism of Atazanavir can be decreased when combined with Telithromycin.
AtomoxetineAtomoxetine may increase the QTc-prolonging activities of Telithromycin.
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Telithromycin.
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Telithromycin.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Telithromycin.
AzelastineThe metabolism of Azelastine can be decreased when combined with Telithromycin.
AzithromycinTelithromycin may increase the QTc-prolonging activities of Azithromycin.
AzithromycinThe metabolism of Telithromycin can be decreased when combined with Azithromycin.
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Telithromycin.
BarnidipineThe serum concentration of Barnidipine can be increased when it is combined with Telithromycin.
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be increased when it is combined with Telithromycin.
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Telithromycin.
BedaquilineBedaquiline may increase the QTc-prolonging activities of Telithromycin.
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Telithromycin.
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Telithromycin.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Telithromycin.
BexaroteneThe serum concentration of Telithromycin can be decreased when it is combined with Bexarotene.
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Telithromycin.
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Telithromycin.
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Telithromycin.
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Telithromycin.
BoceprevirThe metabolism of Boceprevir can be decreased when combined with Telithromycin.
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Telithromycin.
BortezomibBortezomib may increase the QTc-prolonging activities of Telithromycin.
BosentanThe serum concentration of Telithromycin can be decreased when it is combined with Bosentan.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Telithromycin.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Telithromycin.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Telithromycin.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Telithromycin.
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Telithromycin.
BromazepamThe metabolism of Bromazepam can be decreased when combined with Telithromycin.
BromocriptineThe metabolism of Bromocriptine can be decreased when combined with Telithromycin.
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Telithromycin.
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Telithromycin.
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Telithromycin.
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Telithromycin.
BupropionThe metabolism of Bupropion can be decreased when combined with Telithromycin.
BuserelinBuserelin may increase the QTc-prolonging activities of Telithromycin.
BuspironeThe metabolism of Buspirone can be decreased when combined with Telithromycin.
BusulfanThe metabolism of Busulfan can be decreased when combined with Telithromycin.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Telithromycin.
CabergolineThe metabolism of Cabergoline can be decreased when combined with Telithromycin.
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Telithromycin.
CaffeineThe metabolism of Caffeine can be decreased when combined with Telithromycin.
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Telithromycin.
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Telithromycin.
CarbamazepineThe metabolism of Telithromycin can be increased when combined with Carbamazepine.
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Telithromycin.
CariprazineThe metabolism of Cariprazine can be decreased when combined with Telithromycin.
CarvedilolThe metabolism of Carvedilol can be decreased when combined with Telithromycin.
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Telithromycin.
CeliprololThe metabolism of Celiprolol can be decreased when combined with Telithromycin.
CephalexinThe metabolism of Cephalexin can be decreased when combined with Telithromycin.
CeritinibThe serum concentration of Telithromycin can be increased when it is combined with Ceritinib.
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Telithromycin.
CevimelineThe metabolism of Cevimeline can be decreased when combined with Telithromycin.
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Telithromycin.
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Telithromycin.
ChloroquineChloroquine may increase the QTc-prolonging activities of Telithromycin.
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Telithromycin.
ChlorpromazineChlorpromazine may increase the QTc-prolonging activities of Telithromycin.
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Telithromycin.
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Telithromycin.
CiclesonideThe serum concentration of Ciclesonide can be increased when it is combined with Telithromycin.
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Telithromycin.
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Telithromycin.
CiprofloxacinCiprofloxacin may increase the QTc-prolonging activities of Telithromycin.
CisaprideTelithromycin may increase the QTc-prolonging activities of Cisapride.
CitalopramTelithromycin may increase the QTc-prolonging activities of Citalopram.
CitalopramThe metabolism of Telithromycin can be decreased when combined with Citalopram.
ClarithromycinTelithromycin may increase the QTc-prolonging activities of Clarithromycin.
ClemastineThe metabolism of Telithromycin can be decreased when combined with Clemastine.
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Telithromycin.
ClobazamThe metabolism of Clobazam can be decreased when combined with Telithromycin.
Clobetasol propionateThe serum concentration of Clobetasol propionate can be increased when it is combined with Telithromycin.
ClocortoloneThe serum concentration of Clocortolone can be increased when it is combined with Telithromycin.
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Telithromycin.
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Telithromycin.
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Telithromycin.
ClomipramineClomipramine may increase the QTc-prolonging activities of Telithromycin.
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Telithromycin.
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Telithromycin.
ClonidineThe metabolism of Clonidine can be decreased when combined with Telithromycin.
ClopidogrelThe metabolism of Clopidogrel can be decreased when combined with Telithromycin.
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Telithromycin.
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Telithromycin.
ClotrimazoleThe metabolism of Telithromycin can be decreased when combined with Clotrimazole.
ClozapineClozapine may increase the QTc-prolonging activities of Telithromycin.
CobicistatThe serum concentration of Cobicistat can be increased when it is combined with Telithromycin.
CobicistatThe metabolism of Telithromycin can be decreased when combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Telithromycin.
CocaineThe metabolism of Cocaine can be decreased when combined with Telithromycin.
CodeineThe metabolism of Codeine can be decreased when combined with Telithromycin.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Telithromycin.
ConivaptanThe serum concentration of Telithromycin can be increased when it is combined with Conivaptan.
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be decreased when combined with Telithromycin.
Cortisone acetateThe serum concentration of Cortisone acetate can be increased when it is combined with Telithromycin.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Telithromycin.
CrizotinibThe metabolism of Telithromycin can be decreased when combined with Crizotinib.
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Telithromycin.
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Telithromycin.
CyclosporineThe metabolism of Telithromycin can be decreased when combined with Cyclosporine.
Cyproterone acetateThe serum concentration of Telithromycin can be decreased when it is combined with Cyproterone acetate.
CytarabineThe metabolism of Cytarabine can be decreased when combined with Telithromycin.
DabrafenibDabrafenib may increase the QTc-prolonging activities of Telithromycin.
DabrafenibThe metabolism of Dabrafenib can be decreased when combined with Telithromycin.
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Telithromycin.
DantroleneThe metabolism of Dantrolene can be decreased when combined with Telithromycin.
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Telithromycin.
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Telithromycin.
DapsoneThe metabolism of Dapsone can be decreased when combined with Telithromycin.
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Telithromycin.
DarunavirThe metabolism of Darunavir can be decreased when combined with Telithromycin.
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Telithromycin.
DasatinibThe serum concentration of Telithromycin can be increased when it is combined with Dasatinib.
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Telithromycin.
DeferasiroxThe serum concentration of Telithromycin can be decreased when it is combined with Deferasirox.
DegarelixDegarelix may increase the QTc-prolonging activities of Telithromycin.
DehydroepiandrosteroneThe serum concentration of Dehydroepiandrosterone can be increased when it is combined with Telithromycin.
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be increased when it is combined with Telithromycin.
DelavirdineThe metabolism of Telithromycin can be decreased when combined with Delavirdine.
DesfluraneDesflurane may increase the QTc-prolonging activities of Telithromycin.
DesipramineDesipramine may increase the QTc-prolonging activities of Telithromycin.
DesoximetasoneThe serum concentration of Desoximetasone can be increased when it is combined with Telithromycin.
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be increased when it is combined with Telithromycin.
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Telithromycin.
DexamethasoneThe serum concentration of Telithromycin can be decreased when it is combined with Dexamethasone.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Telithromycin.
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Telithromycin.
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Telithromycin.
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Telithromycin.
DiazepamThe metabolism of Diazepam can be decreased when combined with Telithromycin.
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Telithromycin.
DienogestThe serum concentration of Dienogest can be increased when it is combined with Telithromycin.
DiflorasoneThe serum concentration of Diflorasone can be increased when it is combined with Telithromycin.
DifluocortoloneThe serum concentration of Difluocortolone can be increased when it is combined with Telithromycin.
DifluprednateThe serum concentration of Difluprednate can be increased when it is combined with Telithromycin.
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Telithromycin.
DigoxinThe metabolism of Digoxin can be decreased when combined with Telithromycin.
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Telithromycin.
DihydroergotamineThe metabolism of Telithromycin can be decreased when combined with Dihydroergotamine.
DiltiazemThe metabolism of Telithromycin can be decreased when combined with Diltiazem.
DiphenhydramineDiphenhydramine may increase the QTc-prolonging activities of Telithromycin.
DisopyramideTelithromycin may increase the QTc-prolonging activities of Disopyramide.
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Telithromycin.
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Telithromycin.
DofetilideTelithromycin may increase the QTc-prolonging activities of Dofetilide.
DolasetronDolasetron may increase the QTc-prolonging activities of Telithromycin.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Telithromycin.
DonepezilThe metabolism of Donepezil can be decreased when combined with Telithromycin.
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Telithromycin.
DoxepinDoxepin may increase the QTc-prolonging activities of Telithromycin.
DoxepinThe metabolism of Doxepin can be decreased when combined with Telithromycin.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Telithromycin.
DoxycyclineThe metabolism of Telithromycin can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Telithromycin.
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Telithromycin.
DronedaroneThe metabolism of Telithromycin can be decreased when combined with Dronedarone.
DroperidolDroperidol may increase the QTc-prolonging activities of Telithromycin.
DrospirenoneThe serum concentration of Drospirenone can be increased when it is combined with Telithromycin.
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Telithromycin.
EfavirenzThe serum concentration of Telithromycin can be decreased when it is combined with Efavirenz.
EfavirenzThe metabolism of Efavirenz can be decreased when combined with Telithromycin.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Telithromycin.
EliglustatTelithromycin may increase the QTc-prolonging activities of Eliglustat.
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Telithromycin.
EnalaprilThe metabolism of Enalapril can be decreased when combined with Telithromycin.
EnzalutamideThe serum concentration of Enzalutamide can be increased when it is combined with Telithromycin.
EnzalutamideThe serum concentration of Telithromycin can be decreased when it is combined with Enzalutamide.
EpinastineThe metabolism of Epinastine can be decreased when combined with Telithromycin.
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Telithromycin.
EquileninThe serum concentration of Equilenin can be increased when it is combined with Telithromycin.
EquilinThe serum concentration of Equilin can be increased when it is combined with Telithromycin.
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Telithromycin.
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Telithromycin.
ErgonovineThe metabolism of Ergonovine can be decreased when combined with Telithromycin.
ErgotamineThe metabolism of Ergotamine can be decreased when combined with Telithromycin.
EribulinEribulin may increase the QTc-prolonging activities of Telithromycin.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Telithromycin.
ErythromycinTelithromycin may increase the QTc-prolonging activities of Erythromycin.
ErythromycinThe metabolism of Telithromycin can be decreased when combined with Erythromycin.
EscitalopramTelithromycin may increase the QTc-prolonging activities of Escitalopram.
Eslicarbazepine acetateThe serum concentration of Telithromycin can be decreased when it is combined with Eslicarbazepine acetate.
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Telithromycin.
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Telithromycin.
EstradiolThe metabolism of Estradiol can be decreased when combined with Telithromycin.
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Telithromycin.
EstramustineThe metabolism of Estramustine can be decreased when combined with Telithromycin.
EstroneThe serum concentration of Estrone can be increased when it is combined with Telithromycin.
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Telithromycin.
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Telithromycin.
EthanolThe metabolism of Ethanol can be decreased when combined with Telithromycin.
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Telithromycin.
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Telithromycin.
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Telithromycin.
EtizolamThe serum concentration of Etizolam can be increased when it is combined with Telithromycin.
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Telithromycin.
EtoposideThe metabolism of Etoposide can be decreased when combined with Telithromycin.
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Telithromycin.
EtravirineThe serum concentration of Telithromycin can be decreased when it is combined with Etravirine.
EtravirineThe metabolism of Etravirine can be decreased when combined with Telithromycin.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Telithromycin.
ExemestaneThe metabolism of Exemestane can be decreased when combined with Telithromycin.
EzogabineEzogabine may increase the QTc-prolonging activities of Telithromycin.
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Telithromycin.
FamotidineFamotidine may increase the QTc-prolonging activities of Telithromycin.
FelbamateFelbamate may increase the QTc-prolonging activities of Telithromycin.
FelbamateThe metabolism of Felbamate can be decreased when combined with Telithromycin.
FelodipineThe metabolism of Felodipine can be decreased when combined with Telithromycin.
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Telithromycin.
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Telithromycin.
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Telithromycin.
FinasterideThe metabolism of Finasteride can be decreased when combined with Telithromycin.
FingolimodFingolimod may increase the QTc-prolonging activities of Telithromycin.
FingolimodThe metabolism of Fingolimod can be decreased when combined with Telithromycin.
FlecainideTelithromycin may increase the QTc-prolonging activities of Flecainide.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Telithromycin.
FluconazoleFluconazole may increase the QTc-prolonging activities of Telithromycin.
FludrocortisoneThe serum concentration of Fludrocortisone can be increased when it is combined with Telithromycin.
FlumethasoneThe serum concentration of Flumethasone can be increased when it is combined with Telithromycin.
FlunisolideThe serum concentration of Flunisolide can be increased when it is combined with Telithromycin.
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Telithromycin.
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be increased when it is combined with Telithromycin.
FluocinonideThe serum concentration of Fluocinonide can be increased when it is combined with Telithromycin.
FluocortoloneThe serum concentration of Fluocortolone can be increased when it is combined with Telithromycin.
FluorometholoneThe serum concentration of Fluorometholone can be increased when it is combined with Telithromycin.
FluoxetineTelithromycin may increase the QTc-prolonging activities of Fluoxetine.
FlupentixolTelithromycin may increase the QTc-prolonging activities of Flupentixol.
FluprednideneThe serum concentration of Fluprednidene can be increased when it is combined with Telithromycin.
FluprednisoloneThe serum concentration of Fluprednisolone can be increased when it is combined with Telithromycin.
FlurandrenolideThe serum concentration of Flurandrenolide can be increased when it is combined with Telithromycin.
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Telithromycin.
FlutamideThe metabolism of Flutamide can be decreased when combined with Telithromycin.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Telithromycin.
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Telithromycin.
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Telithromycin.
FluvoxamineThe metabolism of Telithromycin can be decreased when combined with Fluvoxamine.
FormoterolFormoterol may increase the QTc-prolonging activities of Telithromycin.
FosamprenavirThe metabolism of Telithromycin can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Telithromycin can be increased when it is combined with Fosaprepitant.
FoscarnetFoscarnet may increase the QTc-prolonging activities of Telithromycin.
FosphenytoinThe metabolism of Telithromycin can be increased when combined with Fosphenytoin.
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Telithromycin.
Fusidic AcidThe serum concentration of Telithromycin can be increased when it is combined with Fusidic Acid.
Gadobenic acidGadobenic acid may increase the QTc-prolonging activities of Telithromycin.
GalantamineGalantamine may increase the QTc-prolonging activities of Telithromycin.
GalantamineThe metabolism of Galantamine can be decreased when combined with Telithromycin.
GefitinibThe metabolism of Gefitinib can be decreased when combined with Telithromycin.
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Telithromycin.
GemifloxacinTelithromycin may increase the QTc-prolonging activities of Gemifloxacin.
GlipizideThe metabolism of Glipizide can be decreased when combined with Telithromycin.
GlyburideThe metabolism of Glyburide can be decreased when combined with Telithromycin.
GoserelinGoserelin may increase the QTc-prolonging activities of Telithromycin.
GranisetronGranisetron may increase the QTc-prolonging activities of Telithromycin.
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Telithromycin.
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Telithromycin.
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Telithromycin.
HaloperidolHaloperidol may increase the QTc-prolonging activities of Telithromycin.
HalothaneThe metabolism of Halothane can be decreased when combined with Telithromycin.
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Telithromycin.
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Telithromycin.
HistrelinHistrelin may increase the QTc-prolonging activities of Telithromycin.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Telithromycin.
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Telithromycin.
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Telithromycin.
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Telithromycin.
HydroxyzineHydroxyzine may increase the QTc-prolonging activities of Telithromycin.
IbandronateIbandronate may increase the QTc-prolonging activities of Telithromycin.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Telithromycin.
IbutilideTelithromycin may increase the QTc-prolonging activities of Ibutilide.
IdelalisibThe serum concentration of Telithromycin can be increased when it is combined with Idelalisib.
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Telithromycin resulting in a loss in efficacy.
IloperidoneTelithromycin may increase the QTc-prolonging activities of Iloperidone.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Telithromycin.
ImatinibThe metabolism of Telithromycin can be decreased when combined with Imatinib.
ImidafenacinThe serum concentration of Imidafenacin can be increased when it is combined with Telithromycin.
ImipramineImipramine may increase the QTc-prolonging activities of Telithromycin.
ImipramineThe metabolism of Imipramine can be decreased when combined with Telithromycin.
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Telithromycin.
IndacaterolIndacaterol may increase the QTc-prolonging activities of Telithromycin.
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Telithromycin.
IndapamideIndapamide may increase the QTc-prolonging activities of Telithromycin.
IndapamideThe metabolism of Indapamide can be decreased when combined with Telithromycin.
IndinavirThe metabolism of Telithromycin can be decreased when combined with Indinavir.
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Telithromycin.
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be increased when Irinotecan is used in combination with Telithromycin.
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Telithromycin.
IsavuconazoniumThe metabolism of Telithromycin can be decreased when combined with Isavuconazonium.
IsofluraneIsoflurane may increase the QTc-prolonging activities of Telithromycin.
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Telithromycin.
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Telithromycin.
IsradipineIsradipine may increase the QTc-prolonging activities of Telithromycin.
IsradipineThe metabolism of Isradipine can be decreased when combined with Telithromycin.
ItraconazoleThe serum concentration of Telithromycin can be increased when it is combined with Itraconazole.
ItraconazoleThe metabolism of Itraconazole can be decreased when combined with Telithromycin.
IvabradineIvabradine may increase the QTc-prolonging activities of Telithromycin.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Telithromycin.
IvacaftorThe serum concentration of Telithromycin can be increased when it is combined with Ivacaftor.
IvermectinThe metabolism of Ivermectin can be decreased when combined with Telithromycin.
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Telithromycin.
IxazomibThe metabolism of Ixazomib can be decreased when combined with Telithromycin.
KetamineThe metabolism of Ketamine can be decreased when combined with Telithromycin.
KetazolamThe metabolism of Ketazolam can be decreased when combined with Telithromycin.
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Telithromycin.
KetoconazoleThe serum concentration of Telithromycin can be increased when it is combined with Ketoconazole.
KetoconazoleThe metabolism of Ketoconazole can be decreased when combined with Telithromycin.
LacosamideThe serum concentration of Lacosamide can be increased when it is combined with Telithromycin.
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Telithromycin.
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Telithromycin.
LapatinibLapatinib may increase the QTc-prolonging activities of Telithromycin.
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Telithromycin.
LenvatinibTelithromycin may increase the QTc-prolonging activities of Lenvatinib.
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Telithromycin.
LetrozoleThe metabolism of Letrozole can be decreased when combined with Telithromycin.
LeuprolideLeuprolide may increase the QTc-prolonging activities of Telithromycin.
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Telithromycin.
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Telithromycin.
LevofloxacinTelithromycin may increase the QTc-prolonging activities of Levofloxacin.
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Telithromycin.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Telithromycin.
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Telithromycin.
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Telithromycin.
LidocaineThe metabolism of Lidocaine can be decreased when combined with Telithromycin.
LisurideThe metabolism of Lisuride can be decreased when combined with Telithromycin.
LithiumLithium may increase the QTc-prolonging activities of Telithromycin.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Telithromycin.
LoperamideThe metabolism of Loperamide can be decreased when combined with Telithromycin.
LopinavirTelithromycin may increase the QTc-prolonging activities of Lopinavir.
LopinavirThe metabolism of Telithromycin can be decreased when combined with Lopinavir.
LoratadineThe metabolism of Loratadine can be decreased when combined with Telithromycin.
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Telithromycin.
LosartanThe metabolism of Losartan can be decreased when combined with Telithromycin.
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Telithromycin.
LovastatinThe metabolism of Telithromycin can be decreased when combined with Lovastatin.
LuliconazoleThe serum concentration of Telithromycin can be increased when it is combined with Luliconazole.
LumefantrineTelithromycin may increase the QTc-prolonging activities of Lumefantrine.
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Telithromycin.
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Telithromycin.
MaprotilineMaprotiline may increase the QTc-prolonging activities of Telithromycin.
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Telithromycin.
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Telithromycin.
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Telithromycin.
MedrysoneThe serum concentration of Medrysone can be increased when it is combined with Telithromycin.
MefloquineMefloquine may increase the QTc-prolonging activities of Telithromycin.
MefloquineThe metabolism of Mefloquine can be decreased when combined with Telithromycin.
MelengestrolThe serum concentration of Melengestrol can be increased when it is combined with Telithromycin.
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Telithromycin.
MethadoneMethadone may increase the QTc-prolonging activities of Telithromycin.
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Telithromycin.
MethotrimeprazineMethotrimeprazine may increase the QTc-prolonging activities of Telithromycin.
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Telithromycin.
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Telithromycin.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Telithromycin.
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Telithromycin.
MetoclopramideMetoclopramide may increase the QTc-prolonging activities of Telithromycin.
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Telithromycin.
MetronidazoleMetronidazole may increase the QTc-prolonging activities of Telithromycin.
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Telithromycin.
MexiletineThe metabolism of Mexiletine can be decreased when combined with Telithromycin.
MianserinThe metabolism of Mianserin can be decreased when combined with Telithromycin.
MibefradilThe metabolism of Mibefradil can be decreased when combined with Telithromycin.
MiconazoleThe metabolism of Miconazole can be decreased when combined with Telithromycin.
MidazolamThe metabolism of Midazolam can be decreased when combined with Telithromycin.
MifepristoneMifepristone may increase the QTc-prolonging activities of Telithromycin.
MirabegronMirabegron may increase the QTc-prolonging activities of Telithromycin.
MirabegronThe metabolism of Mirabegron can be decreased when combined with Telithromycin.
MirtazapineMirtazapine may increase the QTc-prolonging activities of Telithromycin.
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Telithromycin.
MitotaneThe serum concentration of Telithromycin can be decreased when it is combined with Mitotane.
ModafinilThe serum concentration of Telithromycin can be decreased when it is combined with Modafinil.
ModafinilThe metabolism of Modafinil can be decreased when combined with Telithromycin.
MoexiprilMoexipril may increase the QTc-prolonging activities of Telithromycin.
MometasoneThe serum concentration of Mometasone can be increased when it is combined with Telithromycin.
MontelukastThe metabolism of Montelukast can be decreased when combined with Telithromycin.
MorphineThe metabolism of Morphine can be decreased when combined with Telithromycin.
MoxifloxacinMoxifloxacin may increase the QTc-prolonging activities of Telithromycin.
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Telithromycin.
NafcillinThe serum concentration of Telithromycin can be decreased when it is combined with Nafcillin.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Telithromycin.
NaloxoneThe metabolism of Naloxone can be decreased when combined with Telithromycin.
NateglinideThe metabolism of Nateglinide can be decreased when combined with Telithromycin.
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Telithromycin.
NelfinavirNelfinavir may increase the QTc-prolonging activities of Telithromycin.
NelfinavirThe metabolism of Nelfinavir can be decreased when combined with Telithromycin.
NetupitantThe serum concentration of Telithromycin can be increased when it is combined with Netupitant.
NevirapineThe metabolism of Telithromycin can be decreased when combined with Nevirapine.
NicardipineNicardipine may increase the QTc-prolonging activities of Telithromycin.
NicardipineThe metabolism of Nicardipine can be decreased when combined with Telithromycin.
NicotineThe metabolism of Nicotine can be decreased when combined with Telithromycin.
NifedipineThe metabolism of Nifedipine can be decreased when combined with Telithromycin.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Telithromycin.
NilotinibThe metabolism of Telithromycin can be decreased when combined with Nilotinib.
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Telithromycin.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Telithromycin.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Telithromycin.
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Telithromycin.
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Telithromycin.
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Telithromycin.
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Telithromycin.
NorfloxacinNorfloxacin may increase the QTc-prolonging activities of Telithromycin.
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Telithromycin.
NortriptylineNortriptyline may increase the QTc-prolonging activities of Telithromycin.
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Telithromycin.
OctreotideOctreotide may increase the QTc-prolonging activities of Telithromycin.
OfloxacinTelithromycin may increase the QTc-prolonging activities of Ofloxacin.
OlanzapineOlanzapine may increase the QTc-prolonging activities of Telithromycin.
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Telithromycin.
OlaparibThe metabolism of Telithromycin can be decreased when combined with Olaparib.
OlodaterolOlodaterol may increase the QTc-prolonging activities of Telithromycin.
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Telithromycin.
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Telithromycin.
OndansetronOndansetron may increase the QTc-prolonging activities of Telithromycin.
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Telithromycin.
OsimertinibThe serum concentration of Telithromycin can be increased when it is combined with Osimertinib.
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Telithromycin.
OxazepamThe metabolism of Oxazepam can be decreased when combined with Telithromycin.
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Telithromycin.
OxycodoneThe risk or severity of adverse effects can be increased when Telithromycin is combined with Oxycodone.
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Telithromycin.
OxytocinOxytocin may increase the QTc-prolonging activities of Telithromycin.
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Telithromycin.
PalbociclibThe serum concentration of Telithromycin can be increased when it is combined with Palbociclib.
PaliperidoneTelithromycin may increase the QTc-prolonging activities of Paliperidone.
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Telithromycin.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Telithromycin.
PanobinostatPanobinostat may increase the QTc-prolonging activities of Telithromycin.
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Telithromycin.
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Telithromycin.
ParamethasoneThe serum concentration of Paramethasone can be increased when it is combined with Telithromycin.
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Telithromycin.
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Telithromycin.
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Telithromycin.
ParoxetineParoxetine may increase the QTc-prolonging activities of Telithromycin.
PasireotidePasireotide may increase the QTc-prolonging activities of Telithromycin.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Telithromycin.
PazopanibPazopanib may increase the QTc-prolonging activities of Telithromycin.
Peginterferon alfa-2bThe serum concentration of Telithromycin can be increased when it is combined with Peginterferon alfa-2b.
PentamidinePentamidine may increase the QTc-prolonging activities of Telithromycin.
PentobarbitalThe metabolism of Telithromycin can be increased when combined with Pentobarbital.
PerampanelThe metabolism of Perampanel can be decreased when combined with Telithromycin.
PerflutrenPerflutren may increase the QTc-prolonging activities of Telithromycin.
PergolideThe metabolism of Pergolide can be decreased when combined with Telithromycin.
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Telithromycin.
PermethrinThe metabolism of Permethrin can be decreased when combined with Telithromycin.
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Telithromycin.
PethidineThe metabolism of Pethidine can be decreased when combined with Telithromycin.
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Telithromycin.
PhenobarbitalThe metabolism of Telithromycin can be increased when combined with Phenobarbital.
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Telithromycin.
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Telithromycin.
PhenytoinThe metabolism of Telithromycin can be increased when combined with Phenytoin.
Picosulfuric acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Telithromycin.
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Telithromycin.
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Telithromycin.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Telithromycin.
PinacidilThe metabolism of Pinacidil can be decreased when combined with Telithromycin.
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Telithromycin.
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Telithromycin.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Telithromycin.
PodofiloxThe metabolism of Podofilox can be decreased when combined with Telithromycin.
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Telithromycin.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Telithromycin.
PosaconazolePosaconazole may increase the QTc-prolonging activities of Telithromycin.
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Telithromycin.
PranlukastThe serum concentration of Pranlukast can be increased when it is combined with Telithromycin.
PrasugrelThe serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Telithromycin resulting in a loss in efficacy.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Telithromycin.
PrazepamThe metabolism of Prazepam can be decreased when combined with Telithromycin.
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Telithromycin.
PrednicarbateThe serum concentration of Prednicarbate can be increased when it is combined with Telithromycin.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Telithromycin.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Telithromycin.
PregnenoloneThe serum concentration of Pregnenolone can be increased when it is combined with Telithromycin.
PrimaquineTelithromycin may increase the QTc-prolonging activities of Primaquine.
PrimidoneThe metabolism of Telithromycin can be increased when combined with Primidone.
ProcainamideTelithromycin may increase the QTc-prolonging activities of Procainamide.
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Telithromycin.
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Telithromycin.
ProguanilThe metabolism of Proguanil can be decreased when combined with Telithromycin.
PromazinePromazine may increase the QTc-prolonging activities of Telithromycin.
PromethazinePromethazine may increase the QTc-prolonging activities of Telithromycin.
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Telithromycin.
PropafenonePropafenone may increase the QTc-prolonging activities of Telithromycin.
PropofolPropofol may increase the QTc-prolonging activities of Telithromycin.
PropofolThe metabolism of Propofol can be decreased when combined with Telithromycin.
PropranololThe metabolism of Propranolol can be decreased when combined with Telithromycin.
ProtriptylineProtriptyline may increase the QTc-prolonging activities of Telithromycin.
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Telithromycin.
QuazepamThe metabolism of Quazepam can be decreased when combined with Telithromycin.
QuetiapineTelithromycin may increase the QTc-prolonging activities of Quetiapine.
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Telithromycin.
QuinidineTelithromycin may increase the QTc-prolonging activities of Quinidine.
QuinineTelithromycin may increase the QTc-prolonging activities of Quinine.
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Telithromycin.
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Telithromycin.
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Telithromycin.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Telithromycin.
RanolazineRanolazine may increase the QTc-prolonging activities of Telithromycin.
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Telithromycin.
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Telithromycin.
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Telithromycin.
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Telithromycin.
RifabutinThe metabolism of Telithromycin can be increased when combined with Rifabutin.
RifampicinThe metabolism of Telithromycin can be increased when combined with Rifampicin.
RifapentineThe metabolism of Telithromycin can be increased when combined with Rifapentine.
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Telithromycin.
RilpivirineRilpivirine may increase the QTc-prolonging activities of Telithromycin.
RimexoloneThe serum concentration of Rimexolone can be increased when it is combined with Telithromycin.
RimonabantThe metabolism of Rimonabant can be decreased when combined with Telithromycin.
RiociguatThe metabolism of Riociguat can be decreased when combined with Telithromycin.
RisperidoneRisperidone may increase the QTc-prolonging activities of Telithromycin.
RisperidoneThe metabolism of Risperidone can be decreased when combined with Telithromycin.
RitonavirRitonavir may increase the QTc-prolonging activities of Telithromycin.
RitonavirThe metabolism of Ritonavir can be decreased when combined with Telithromycin.
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Telithromycin.
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Telithromycin.
RolapitantThe metabolism of Rolapitant can be decreased when combined with Telithromycin.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Telithromycin.
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Telithromycin.
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Telithromycin.
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Telithromycin.
RotigotineThe metabolism of Rotigotine can be decreased when combined with Telithromycin.
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Telithromycin.
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Telithromycin.
SalbutamolSalbutamol may increase the QTc-prolonging activities of Telithromycin.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Telithromycin.
SalmeterolSalmeterol may increase the QTc-prolonging activities of Telithromycin.
SaquinavirTelithromycin may increase the QTc-prolonging activities of Saquinavir.
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Telithromycin.
SelegilineThe metabolism of Selegiline can be decreased when combined with Telithromycin.
SelexipagThe metabolism of Selexipag can be decreased when combined with Telithromycin.
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Telithromycin.
SertindoleThe metabolism of Sertindole can be decreased when combined with Telithromycin.
SertralineSertraline may increase the QTc-prolonging activities of Telithromycin.
SertralineThe metabolism of Sertraline can be decreased when combined with Telithromycin.
SevofluraneSevoflurane may increase the QTc-prolonging activities of Telithromycin.
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Telithromycin.
SibutramineThe metabolism of Sibutramine can be decreased when combined with Telithromycin.
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Telithromycin.
SildenafilThe metabolism of Telithromycin can be decreased when combined with Sildenafil.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Telithromycin.
SiltuximabThe serum concentration of Telithromycin can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Telithromycin can be increased when it is combined with Simeprevir.
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Telithromycin.
SirolimusThe metabolism of Sirolimus can be decreased when combined with Telithromycin.
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Telithromycin.
SolifenacinSolifenacin may increase the QTc-prolonging activities of Telithromycin.
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Telithromycin.
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Telithromycin.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Telithromycin.
SorafenibSorafenib may increase the QTc-prolonging activities of Telithromycin.
SotalolTelithromycin may increase the QTc-prolonging activities of Sotalol.
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Telithromycin.
St. John's WortThe serum concentration of Telithromycin can be decreased when it is combined with St. John's Wort.
StiripentolThe serum concentration of Telithromycin can be increased when it is combined with Stiripentol.
SufentanilThe metabolism of Sufentanil can be decreased when combined with Telithromycin.
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Telithromycin.
SulfamethoxazoleSulfamethoxazole may increase the QTc-prolonging activities of Telithromycin.
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Telithromycin.
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Telithromycin.
SulfisoxazoleTelithromycin may increase the QTc-prolonging activities of Sulfisoxazole.
SulfisoxazoleThe metabolism of Telithromycin can be decreased when combined with Sulfisoxazole.
SunitinibSunitinib may increase the QTc-prolonging activities of Telithromycin.
SunitinibThe metabolism of Sunitinib can be decreased when combined with Telithromycin.
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Telithromycin.
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Telithromycin.
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Telithromycin.
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Telithromycin.
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Telithromycin.
TamoxifenTamoxifen may increase the QTc-prolonging activities of Telithromycin.
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Telithromycin.
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Telithromycin.
TasimelteonThe serum concentration of Tasimelteon can be increased when it is combined with Telithromycin.
TasosartanThe metabolism of Tasosartan can be decreased when combined with Telithromycin.
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Telithromycin.
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Telithromycin.
TelaprevirThe metabolism of Telithromycin can be decreased when combined with Telaprevir.
TelavancinTelithromycin may increase the QTc-prolonging activities of Telavancin.
TemazepamThe metabolism of Temazepam can be decreased when combined with Telithromycin.
TemsirolimusThe metabolism of Temsirolimus can be decreased when combined with Telithromycin.
TeniposideThe metabolism of Teniposide can be decreased when combined with Telithromycin.
TenofovirThe metabolism of Telithromycin can be decreased when combined with Tenofovir.
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Telithromycin.
TerbutalineTerbutaline may increase the QTc-prolonging activities of Telithromycin.
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Telithromycin.
TeriflunomideThe serum concentration of Telithromycin can be decreased when it is combined with Teriflunomide.
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Telithromycin.
TestosteroneThe metabolism of Testosterone can be decreased when combined with Telithromycin.
TetrabenazineTelithromycin may increase the QTc-prolonging activities of Tetrabenazine.
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Telithromycin.
TheophyllineThe metabolism of Theophylline can be decreased when combined with Telithromycin.
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Telithromycin.
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Telithromycin.
ThiothixeneThiothixene may increase the QTc-prolonging activities of Telithromycin.
TiagabineThe metabolism of Tiagabine can be decreased when combined with Telithromycin.
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Telithromycin resulting in a loss in efficacy.
TiclopidineThe metabolism of Telithromycin can be decreased when combined with Ticlopidine.
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Telithromycin.
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Telithromycin.
TipranavirThe metabolism of Tipranavir can be decreased when combined with Telithromycin.
TixocortolThe serum concentration of Tixocortol can be increased when it is combined with Telithromycin.
TizanidineTizanidine may increase the QTc-prolonging activities of Telithromycin.
TocilizumabThe serum concentration of Telithromycin can be decreased when it is combined with Tocilizumab.
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Telithromycin.
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Telithromycin.
TolterodineTolterodine may increase the QTc-prolonging activities of Telithromycin.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Telithromycin.
ToremifeneThe risk or severity of adverse effects can be increased when Telithromycin is combined with Toremifene.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Telithromycin.
TramadolThe serum concentration of Tramadol can be increased when it is combined with Telithromycin.
Trastuzumab emtansineThe serum concentration of the active metabolites of Trastuzumab emtansine can be increased when Trastuzumab emtansine is used in combination with Telithromycin.
TrazodoneTrazodone may increase the QTc-prolonging activities of Telithromycin.
TrazodoneThe metabolism of Trazodone can be decreased when combined with Telithromycin.
TreprostinilTreprostinil may increase the QTc-prolonging activities of Telithromycin.
TretinoinThe metabolism of Tretinoin can be decreased when combined with Telithromycin.
TriamcinoloneThe serum concentration of Triamcinolone can be increased when it is combined with Telithromycin.
TriazolamThe metabolism of Triazolam can be decreased when combined with Telithromycin.
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Telithromycin.
TrimethoprimTrimethoprim may increase the QTc-prolonging activities of Telithromycin.
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Telithromycin.
TrimipramineTrimipramine may increase the QTc-prolonging activities of Telithromycin.
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Telithromycin.
TriptorelinTriptorelin may increase the QTc-prolonging activities of Telithromycin.
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Telithromycin.
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Telithromycin.
UdenafilThe metabolism of Udenafil can be decreased when combined with Telithromycin.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Telithromycin.
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Telithromycin.
VandetanibTelithromycin may increase the QTc-prolonging activities of Vandetanib.
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Telithromycin.
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Telithromycin.
VardenafilVardenafil may increase the QTc-prolonging activities of Telithromycin.
VemurafenibThe serum concentration of Telithromycin can be increased when it is combined with Vemurafenib.
VenlafaxineVenlafaxine may increase the QTc-prolonging activities of Telithromycin.
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Telithromycin.
VerapamilTelithromycin may increase the bradycardic activities of Verapamil.
VerapamilThe metabolism of Telithromycin can be decreased when combined with Verapamil.
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Telithromycin.
VilanterolVilanterol may increase the QTc-prolonging activities of Telithromycin.
VilanterolThe metabolism of Vilanterol can be decreased when combined with Telithromycin.
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Telithromycin.
VinblastineThe metabolism of Vinblastine can be decreased when combined with Telithromycin.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Telithromycin.
VindesineThe serum concentration of Vindesine can be increased when it is combined with Telithromycin.
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Telithromycin.
VismodegibThe metabolism of Vismodegib can be decreased when combined with Telithromycin.
VorapaxarThe serum concentration of Vorapaxar can be increased when it is combined with Telithromycin.
VoriconazoleVoriconazole may increase the QTc-prolonging activities of Telithromycin.
VoriconazoleThe metabolism of Voriconazole can be decreased when combined with Telithromycin.
VorinostatVorinostat may increase the QTc-prolonging activities of Telithromycin.
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Telithromycin.
WarfarinThe metabolism of Warfarin can be decreased when combined with Telithromycin.
YohimbineThe metabolism of Yohimbine can be decreased when combined with Telithromycin.
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Telithromycin.
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Telithromycin.
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Telithromycin.
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Telithromycin.
ZileutonThe metabolism of Zileuton can be decreased when combined with Telithromycin.
ZiprasidoneTelithromycin may increase the QTc-prolonging activities of Ziprasidone.
ZiprasidoneThe metabolism of Telithromycin can be decreased when combined with Ziprasidone.
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Telithromycin.
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Telithromycin.
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Telithromycin.
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Telithromycin.
ZuclopenthixolTelithromycin may increase the QTc-prolonging activities of Zuclopenthixol.
Food Interactions
  • Take without regard to meals.

Targets

1. 23S rRNA
Kind
Nucleotide
Organism
Enteric bacteria and other eubacteria
Pharmacological action
yes
Actions
inhibitor
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Reinert RR, Al-Lahham A: Time-kill study of the activity of telithromycin against macrolide-resistant Streptococcus pneumoniae Isolates with 23S rRNA mutations and changes in ribosomal proteins L4 and L22. Antimicrob Agents Chemother. 2005 Jul;49(7):3011-3. [PubMed:15980387 ]
  4. Farrell DJ, Shackcloth J, Barbadora KA, Green MD: Streptococcus pyogenes isolates with high-level macrolide resistance and reduced susceptibility to telithromycin associated with 23S rRNA mutations. Antimicrob Agents Chemother. 2006 Feb;50(2):817-8. [PubMed:16436755 ]
  5. Hirakata Y, Mizuta Y, Wada A, Kondoh A, Kurihara S, Izumikawa K, Seki M, Yanagihara K, Miyazaki Y, Tomono K, Kohno S: The first telithromycin-resistant Streptococcus pneumoniae isolate in Japan associated with erm(B) and mutations in 23S rRNA and riboprotein L4. Jpn J Infect Dis. 2007 Feb;60(1):48-50. [PubMed:17314426 ]
  6. Champney WS, Mentens N, Zurawick K: An examination of the differential sensitivity to ketolide antibiotics in ermB strains of Streptococcus pyogenes and Streptococcus pneumoniae. Curr Microbiol. 2004 Oct;49(4):239-47. [PubMed:15386111 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Bearden DT, Neuhauser MM, Garey KW: Telithromycin: an oral ketolide for respiratory infections. Pharmacotherapy. 2001 Oct;21(10):1204-22. [PubMed:11601667 ]
  2. Zhanel GG, Walters M, Noreddin A, Vercaigne LM, Wierzbowski A, Embil JM, Gin AS, Douthwaite S, Hoban DJ: The ketolides: a critical review. Drugs. 2002;62(12):1771-804. [PubMed:12149046 ]
  3. Reed M, Wall GC, Shah NP, Heun JM, Hicklin GA: Verapamil toxicity resulting from a probable interaction with telithromycin. Ann Pharmacother. 2005 Feb;39(2):357-60. Epub 2004 Dec 14. [PubMed:15598962 ]
  4. Shi J, Chapel S, Montay G, Hardy P, Barrett JS, Sica D, Swan SK, Noveck R, Leroy B, Bhargava VO: Effect of ketoconazole on the pharmacokinetics and safety of telithromycin and clarithromycin in older subjects with renal impairment. Int J Clin Pharmacol Ther. 2005 Mar;43(3):123-33. [PubMed:15792396 ]
  5. Nguyen M, Chung EP: Telithromycin: the first ketolide antimicrobial. Clin Ther. 2005 Aug;27(8):1144-63. [PubMed:16199242 ]
  6. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  7. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
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Drug created on June 13, 2005 07:24 / Updated on September 30, 2016 02:25