You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.
Identification
NameRifapentine
Accession NumberDB01201  (APRD01217)
TypeSmall Molecule
GroupsApproved
DescriptionRifapentine is an antibiotic drug used in the treatment of tuberculosis. It inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme.
Structure
Thumb
Synonyms
3-(((4-Cyclopentyl-1-piperazinyl)imino)methyl)rifamycin
Cyclopentylrifampicin
Priftin (tn)
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Priftintablet, film coated150 mg/1oralSanofi Aventis U.S. Llc1998-06-22Not applicableUs
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIXJM390A33U
CAS number61379-65-5
WeightAverage: 877.0307
Monoisotopic: 876.452073532
Chemical FormulaC47H64N4O12
InChI KeyInChIKey=WDZCUPBHRAEYDL-GZAUEHORSA-N
InChI
InChI=1S/C47H64N4O12/c1-24-13-12-14-25(2)46(59)49-37-32(23-48-51-20-18-50(19-21-51)31-15-10-11-16-31)41(56)34-35(42(37)57)40(55)29(6)44-36(34)45(58)47(8,63-44)61-22-17-33(60-9)26(3)43(62-30(7)52)28(5)39(54)27(4)38(24)53/h12-14,17,22-24,26-28,31,33,38-39,43,53-57H,10-11,15-16,18-21H2,1-9H3,(H,49,59)/b13-12+,22-17+,25-14-,48-23+/t24-,26+,27+,28+,33-,38-,39+,43+,47-/m0/s1
IUPAC Name
(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-26-[(1E)-[(4-cyclopentylpiperazin-1-yl)imino]methyl]-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1⁴,⁷.0⁵,²⁸]triaconta-1(28),2,4,9,19,21,25(29),26-octaen-13-yl acetate
SMILES
CO[[email protected]]1\C=C\O[C@@]2(C)OC3=C(C2=O)C2=C(C(O)=C3C)C(O)=C(NC(=O)\C(C)=C/C=C/[[email protected]](C)[[email protected]](O)[C@@H](C)[C@@H](O)[C@@H](C)[[email protected]](OC(C)=O)[C@@H]1C)C(\C=N\N1CCN(CC1)C1CCCC1)=C2O
Taxonomy
ClassificationNot classified
Pharmacology
IndicationFor the treatment of pulmonary tuberculosis.
PharmacodynamicsRifapentine is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. It is bactericidal and has a very broad spectrum of activity against most gram-positive and gram-negative organisms (including Pseudomonas aeruginosa) and specifically Mycobacterium tuberculosis. Because of rapid emergence of resistant bacteria, use is restricted to treatment of mycobacterial infections and a few other indications. Rifampin is well absorbed when taken orally and is distributed widely in body tissues and fluids, including the CSF. It is metabolized in the liver and eliminated in bile and, to a much lesser extent, in urine, but dose adjustments are unnecessary with renal insufficiency.
Mechanism of actionRifapentine has shown higher bacteriostatic and bactericidal activities especially against intracellular bacteria growing in human monocyte-derived macrophages. Rifapentine inhibits DNA-dependent RNA polymerase in susceptible strains of M. tuberculosis. Rifapentine acts via the inhibition of DNA-dependent RNA polymerase, leading to a suppression of RNA synthesis and cell death.
Related Articles
AbsorptionRapidly and well absorbed from the gastrointestinal tract.
Volume of distribution
  • 70.2 ± 9.1 L
Protein binding97.7% (bound to plasma proteins)
Metabolism

Hepatic

Route of eliminationFollowing a single 600 mg oral dose of radiolabeled rifapentine to healthy volunteers (n=4), 87% of the total 14C rifapentine was recovered in the urine (17%) and feces (70%).
Half lifeNot Available
Clearance
  • Apparent Oral cl=2.51 +/- 0.14 L/h [Male tuberculosis patients who received 600 mg rifapentine in combination with isoniazid, pyrazinamide and ethambutol]
  • Apparent Oral cl=1.69 +/- 0.41 L/h [Female tuberculosis patients who received 600 mg rifapentine in combination with isoniazid, pyrazinamide and ethambutol]
ToxicityNot Available
Affected organisms
  • Mycobacterium tuberculosis
  • Mycobacterium
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.6848
Blood Brain Barrier-0.9659
Caco-2 permeable-0.6609
P-glycoprotein substrateSubstrate0.8997
P-glycoprotein inhibitor IInhibitor0.7632
P-glycoprotein inhibitor IINon-inhibitor0.5252
Renal organic cation transporterNon-inhibitor0.8267
CYP450 2C9 substrateNon-substrate0.8555
CYP450 2D6 substrateNon-substrate0.9115
CYP450 3A4 substrateSubstrate0.7246
CYP450 1A2 substrateNon-inhibitor0.8865
CYP450 2C9 inhibitorNon-inhibitor0.8436
CYP450 2D6 inhibitorNon-inhibitor0.9073
CYP450 2C19 inhibitorNon-inhibitor0.8449
CYP450 3A4 inhibitorNon-inhibitor0.7042
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8274
Ames testNon AMES toxic0.598
CarcinogenicityNon-carcinogens0.8187
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.3722 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9221
hERG inhibition (predictor II)Inhibitor0.6821
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Tablet, film coatedoral150 mg/1
Prices
Unit descriptionCostUnit
Priftin 150 mg tablet3.96USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
logP4Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0213 mg/mLALOGPS
logP4.83ALOGPS
logP3.56ChemAxon
logS-4.6ALOGPS
pKa (Strongest Acidic)7.01ChemAxon
pKa (Strongest Basic)7.98ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count14ChemAxon
Hydrogen Donor Count6ChemAxon
Polar Surface Area220.15 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity242 m3·mol-1ChemAxon
Polarizability93.14 Å3ChemAxon
Number of Rings6ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesJ04AB05
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelDownload (1.74 MB)
MSDSDownload (58.3 KB)
Interactions
Drug Interactions
Drug
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be decreased when it is combined with Rifapentine.
AbirateroneThe serum concentration of Abiraterone can be decreased when it is combined with Rifapentine.
AceclofenacThe metabolism of Aceclofenac can be increased when combined with Rifapentine.
AcenocoumarolThe metabolism of Acenocoumarol can be increased when combined with Rifapentine.
AcetaminophenThe metabolism of Acetaminophen can be increased when combined with Rifapentine.
Acetylsalicylic acidThe metabolism of Acetylsalicylic acid can be increased when combined with Rifapentine.
AdinazolamThe metabolism of Adinazolam can be increased when combined with Rifapentine.
AlbendazoleThe metabolism of Albendazole can be increased when combined with Rifapentine.
AlclometasoneThe serum concentration of Alclometasone can be decreased when it is combined with Rifapentine.
AldosteroneThe serum concentration of Aldosterone can be decreased when it is combined with Rifapentine.
AlfentanilThe metabolism of Alfentanil can be increased when combined with Rifapentine.
AlfuzosinThe metabolism of Alfuzosin can be increased when combined with Rifapentine.
AliskirenThe metabolism of Aliskiren can be increased when combined with Rifapentine.
AllylestrenolThe metabolism of Allylestrenol can be increased when combined with Rifapentine.
AlmotriptanThe metabolism of Almotriptan can be increased when combined with Rifapentine.
AlogliptinThe metabolism of Alogliptin can be increased when combined with Rifapentine.
AlosetronThe metabolism of Alosetron can be increased when combined with Rifapentine.
AlprazolamThe metabolism of Alprazolam can be increased when combined with Rifapentine.
AmbrisentanThe metabolism of Ambrisentan can be increased when combined with Rifapentine.
AmbroxolThe metabolism of Ambroxol can be increased when combined with Rifapentine.
AmcinonideThe serum concentration of Amcinonide can be decreased when it is combined with Rifapentine.
AminophenazoneThe metabolism of Aminophenazone can be increased when combined with Rifapentine.
AminophyllineThe metabolism of Aminophylline can be increased when combined with Rifapentine.
AmiodaroneThe metabolism of Amiodarone can be increased when combined with Rifapentine.
AmitriptylineThe metabolism of Amitriptyline can be increased when combined with Rifapentine.
AmlodipineThe metabolism of Amlodipine can be increased when combined with Rifapentine.
AmodiaquineThe metabolism of Amodiaquine can be increased when combined with Rifapentine.
AmprenavirThe metabolism of Amprenavir can be increased when combined with Rifapentine.
AntipyrineThe metabolism of Antipyrine can be increased when combined with Rifapentine.
ApixabanThe serum concentration of Apixaban can be decreased when it is combined with Rifapentine.
ApremilastThe serum concentration of Apremilast can be decreased when it is combined with Rifapentine.
AprepitantThe metabolism of Aprepitant can be increased when combined with Rifapentine.
Arachidonic AcidThe metabolism of Arachidonic Acid can be increased when combined with Rifapentine.
ArformoterolThe metabolism of Arformoterol can be increased when combined with Rifapentine.
ArgatrobanThe metabolism of Argatroban can be increased when combined with Rifapentine.
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Rifapentine.
ArtemetherThe serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with Rifapentine resulting in a loss in efficacy.
AsenapineThe metabolism of Asenapine can be increased when combined with Rifapentine.
AstemizoleThe metabolism of Astemizole can be increased when combined with Rifapentine.
AtazanavirThe metabolism of Atazanavir can be increased when combined with Rifapentine.
AtorvastatinThe metabolism of Atorvastatin can be increased when combined with Rifapentine.
AvanafilThe metabolism of Avanafil can be increased when combined with Rifapentine.
AxitinibThe serum concentration of Axitinib can be decreased when it is combined with Rifapentine.
AzelastineThe metabolism of Azelastine can be increased when combined with Rifapentine.
AzithromycinThe metabolism of Azithromycin can be increased when combined with Rifapentine.
BanoxantroneThe metabolism of Banoxantrone can be increased when combined with Rifapentine.
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be decreased when it is combined with Rifapentine.
BedaquilineThe serum concentration of Bedaquiline can be decreased when it is combined with Rifapentine.
BenzphetamineThe metabolism of Benzphetamine can be increased when combined with Rifapentine.
Benzyl alcoholThe metabolism of Benzyl alcohol can be increased when combined with Rifapentine.
BeraprostThe metabolism of Beraprost can be increased when combined with Rifapentine.
BetamethasoneThe serum concentration of Betamethasone can be decreased when it is combined with Rifapentine.
BexaroteneThe metabolism of Bexarotene can be increased when combined with Rifapentine.
BezafibrateThe metabolism of Bezafibrate can be increased when combined with Rifapentine.
BicalutamideThe metabolism of Bicalutamide can be increased when combined with Rifapentine.
BisoprololThe metabolism of Bisoprolol can be increased when combined with Rifapentine.
BoceprevirThe serum concentration of Boceprevir can be decreased when it is combined with Rifapentine.
BortezomibThe serum concentration of Bortezomib can be decreased when it is combined with Rifapentine.
BosentanThe metabolism of Bosentan can be increased when combined with Rifapentine.
BosutinibThe serum concentration of Bosutinib can be decreased when it is combined with Rifapentine.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be decreased when it is combined with Rifapentine.
BrexpiprazoleThe serum concentration of Brexpiprazole can be decreased when it is combined with Rifapentine.
BrinzolamideThe metabolism of Brinzolamide can be increased when combined with Rifapentine.
BromazepamThe metabolism of Bromazepam can be increased when combined with Rifapentine.
BromocriptineThe metabolism of Bromocriptine can be increased when combined with Rifapentine.
BrompheniramineThe metabolism of Brompheniramine can be increased when combined with Rifapentine.
BudesonideThe serum concentration of Budesonide can be decreased when it is combined with Rifapentine.
BupivacaineThe metabolism of Bupivacaine can be increased when combined with Rifapentine.
BuprenorphineThe metabolism of Buprenorphine can be increased when combined with Rifapentine.
BupropionThe metabolism of Bupropion can be increased when combined with Rifapentine.
BuspironeThe metabolism of Buspirone can be increased when combined with Rifapentine.
BusulfanThe metabolism of Busulfan can be increased when combined with Rifapentine.
CabazitaxelThe metabolism of Cabazitaxel can be increased when combined with Rifapentine.
CabergolineThe metabolism of Cabergoline can be increased when combined with Rifapentine.
CabozantinibThe serum concentration of Cabozantinib can be decreased when it is combined with Rifapentine.
CaffeineThe metabolism of Caffeine can be increased when combined with Rifapentine.
CalcitriolThe metabolism of Calcitriol can be increased when combined with Rifapentine.
CanagliflozinThe metabolism of Canagliflozin can be increased when combined with Rifapentine.
CandesartanThe metabolism of Candesartan can be increased when combined with Rifapentine.
CannabidiolThe serum concentration of Cannabidiol can be decreased when it is combined with Rifapentine.
CarbamazepineThe metabolism of Carbamazepine can be increased when combined with Rifapentine.
CarbinoxamineThe metabolism of Carbinoxamine can be increased when combined with Rifapentine.
CariprazineThe metabolism of Cariprazine can be increased when combined with Rifapentine.
CarvedilolThe metabolism of Carvedilol can be increased when combined with Rifapentine.
CelecoxibThe metabolism of Celecoxib can be increased when combined with Rifapentine.
CeliprololThe metabolism of Celiprolol can be increased when combined with Rifapentine.
CephalexinThe metabolism of Cephalexin can be increased when combined with Rifapentine.
CeritinibThe serum concentration of Ceritinib can be decreased when it is combined with Rifapentine.
CerivastatinThe metabolism of Cerivastatin can be increased when combined with Rifapentine.
CevimelineThe metabolism of Cevimeline can be increased when combined with Rifapentine.
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be increased when combined with Rifapentine.
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be increased when combined with Rifapentine.
ChloroquineThe metabolism of Chloroquine can be increased when combined with Rifapentine.
ChlorphenamineThe metabolism of Chlorphenamine can be increased when combined with Rifapentine.
ChlorpromazineThe metabolism of Chlorpromazine can be increased when combined with Rifapentine.
ChlorpropamideThe metabolism of Chlorpropamide can be increased when combined with Rifapentine.
ChlorzoxazoneThe metabolism of Chlorzoxazone can be increased when combined with Rifapentine.
CholecalciferolThe metabolism of Cholecalciferol can be increased when combined with Rifapentine.
CiclesonideThe serum concentration of Ciclesonide can be decreased when it is combined with Rifapentine.
CilostazolThe metabolism of Cilostazol can be increased when combined with Rifapentine.
CinacalcetThe metabolism of Cinacalcet can be increased when combined with Rifapentine.
CinnarizineThe metabolism of Cinnarizine can be increased when combined with Rifapentine.
CisaprideThe metabolism of Cisapride can be increased when combined with Rifapentine.
CitalopramThe metabolism of Citalopram can be increased when combined with Rifapentine.
ClarithromycinThe serum concentration of the active metabolites of Clarithromycin can be increased when Clarithromycin is used in combination with Rifapentine.
ClindamycinThe metabolism of Clindamycin can be increased when combined with Rifapentine.
ClobazamThe metabolism of Clobazam can be increased when combined with Rifapentine.
Clobetasol propionateThe serum concentration of Clobetasol propionate can be decreased when it is combined with Rifapentine.
ClocortoloneThe serum concentration of Clocortolone can be decreased when it is combined with Rifapentine.
ClofazimineThe metabolism of Clofazimine can be increased when combined with Rifapentine.
ClofibrateThe metabolism of Clofibrate can be increased when combined with Rifapentine.
clomethiazoleThe metabolism of clomethiazole can be increased when combined with Rifapentine.
ClomipramineThe metabolism of Clomipramine can be increased when combined with Rifapentine.
ClonazepamThe metabolism of Clonazepam can be increased when combined with Rifapentine.
ClonidineThe metabolism of Clonidine can be increased when combined with Rifapentine.
ClopidogrelThe metabolism of Clopidogrel can be increased when combined with Rifapentine.
ClorazepateThe metabolism of Clorazepate can be increased when combined with Rifapentine.
ClotiazepamThe metabolism of Clotiazepam can be increased when combined with Rifapentine.
ClozapineThe serum concentration of Clozapine can be decreased when it is combined with Rifapentine.
CobicistatThe serum concentration of Cobicistat can be decreased when it is combined with Rifapentine.
CobimetinibThe serum concentration of Cobimetinib can be decreased when it is combined with Rifapentine.
CocaineThe metabolism of Cocaine can be increased when combined with Rifapentine.
CodeineThe metabolism of Codeine can be increased when combined with Rifapentine.
ColchicineThe metabolism of Colchicine can be increased when combined with Rifapentine.
ConivaptanThe metabolism of Conivaptan can be increased when combined with Rifapentine.
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be increased when combined with Rifapentine.
Cortisone acetateThe serum concentration of Cortisone acetate can be decreased when it is combined with Rifapentine.
CrizotinibThe serum concentration of Crizotinib can be decreased when it is combined with Rifapentine.
CyclobenzaprineThe metabolism of Cyclobenzaprine can be increased when combined with Rifapentine.
CyclophosphamideThe metabolism of Cyclophosphamide can be increased when combined with Rifapentine.
CyclosporineThe metabolism of Cyclosporine can be increased when combined with Rifapentine.
CytarabineThe metabolism of Cytarabine can be increased when combined with Rifapentine.
DabrafenibThe metabolism of Dabrafenib can be increased when combined with Rifapentine.
DaclatasvirThe serum concentration of Daclatasvir can be decreased when it is combined with Rifapentine.
DantroleneThe metabolism of Dantrolene can be increased when combined with Rifapentine.
DapagliflozinThe metabolism of Dapagliflozin can be increased when combined with Rifapentine.
DapsoneThe metabolism of Dapsone can be increased when combined with Rifapentine.
DarifenacinThe metabolism of Darifenacin can be increased when combined with Rifapentine.
DarunavirThe serum concentration of Darunavir can be decreased when it is combined with Rifapentine.
DasabuvirThe metabolism of Dasabuvir can be increased when combined with Rifapentine.
DasatinibThe serum concentration of Dasatinib can be decreased when it is combined with Rifapentine.
DaunorubicinThe metabolism of Daunorubicin can be increased when combined with Rifapentine.
DehydroepiandrosteroneThe serum concentration of Dehydroepiandrosterone can be decreased when it is combined with Rifapentine.
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be decreased when it is combined with Rifapentine.
DelavirdineThe metabolism of Delavirdine can be increased when combined with Rifapentine.
DesoximetasoneThe serum concentration of Desoximetasone can be decreased when it is combined with Rifapentine.
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be decreased when it is combined with Rifapentine.
DesvenlafaxineThe metabolism of Desvenlafaxine can be increased when combined with Rifapentine.
DexamethasoneThe serum concentration of Dexamethasone can be decreased when it is combined with Rifapentine.
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be decreased when it is combined with Rifapentine.
DextromethorphanThe metabolism of Dextromethorphan can be increased when combined with Rifapentine.
DextropropoxypheneThe metabolism of Dextropropoxyphene can be increased when combined with Rifapentine.
DiazepamThe metabolism of Diazepam can be increased when combined with Rifapentine.
DiclofenacThe serum concentration of Diclofenac can be decreased when it is combined with Rifapentine.
DicoumarolThe metabolism of Dicoumarol can be increased when combined with Rifapentine.
DienogestThe serum concentration of Dienogest can be decreased when it is combined with Rifapentine.
DiflorasoneThe serum concentration of Diflorasone can be decreased when it is combined with Rifapentine.
DifluocortoloneThe serum concentration of Difluocortolone can be decreased when it is combined with Rifapentine.
DifluprednateThe serum concentration of Difluprednate can be decreased when it is combined with Rifapentine.
DigitoxinThe metabolism of Digitoxin can be increased when combined with Rifapentine.
DigoxinThe metabolism of Digoxin can be increased when combined with Rifapentine.
DihydrocodeineThe metabolism of Dihydrocodeine can be increased when combined with Rifapentine.
DihydroergotamineThe metabolism of Dihydroergotamine can be increased when combined with Rifapentine.
DiltiazemThe metabolism of Diltiazem can be increased when combined with Rifapentine.
DiphenhydramineThe metabolism of Diphenhydramine can be increased when combined with Rifapentine.
DisopyramideThe metabolism of Disopyramide can be increased when combined with Rifapentine.
DisulfiramThe metabolism of Disulfiram can be increased when combined with Rifapentine.
DocetaxelThe metabolism of Docetaxel can be increased when combined with Rifapentine.
DofetilideThe metabolism of Dofetilide can be increased when combined with Rifapentine.
DolasetronThe metabolism of Dolasetron can be increased when combined with Rifapentine.
DomperidoneThe metabolism of Domperidone can be increased when combined with Rifapentine.
DonepezilThe metabolism of Donepezil can be increased when combined with Rifapentine.
DopamineThe metabolism of Dopamine can be increased when combined with Rifapentine.
DorzolamideThe metabolism of Dorzolamide can be increased when combined with Rifapentine.
DoxepinThe metabolism of Doxepin can be increased when combined with Rifapentine.
DoxorubicinThe serum concentration of Doxorubicin can be decreased when it is combined with Rifapentine.
DronabinolThe serum concentration of Dronabinol can be decreased when it is combined with Rifapentine.
DronedaroneThe serum concentration of Dronedarone can be decreased when it is combined with Rifapentine.
DutasterideThe metabolism of Dutasteride can be increased when combined with Rifapentine.
EfavirenzThe metabolism of Efavirenz can be increased when combined with Rifapentine.
EletriptanThe metabolism of Eletriptan can be increased when combined with Rifapentine.
EliglustatThe serum concentration of Eliglustat can be decreased when it is combined with Rifapentine.
EltrombopagThe metabolism of Eltrombopag can be increased when combined with Rifapentine.
ElvitegravirThe serum concentration of Elvitegravir can be decreased when it is combined with Rifapentine.
EnalaprilThe metabolism of Enalapril can be increased when combined with Rifapentine.
EnzalutamideThe serum concentration of Enzalutamide can be decreased when it is combined with Rifapentine.
EpinastineThe metabolism of Epinastine can be increased when combined with Rifapentine.
EplerenoneThe metabolism of Eplerenone can be increased when combined with Rifapentine.
EpoprostenolThe metabolism of Epoprostenol can be increased when combined with Rifapentine.
EquileninThe serum concentration of Equilenin can be decreased when it is combined with Rifapentine.
EquilinThe serum concentration of Equilin can be decreased when it is combined with Rifapentine.
ErgocalciferolThe metabolism of Ergocalciferol can be increased when combined with Rifapentine.
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be increased when combined with Rifapentine.
ErgonovineThe metabolism of Ergonovine can be increased when combined with Rifapentine.
ErgotamineThe metabolism of Ergotamine can be increased when combined with Rifapentine.
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Rifapentine.
ErythromycinThe metabolism of Erythromycin can be increased when combined with Rifapentine.
EscitalopramThe metabolism of Escitalopram can be increased when combined with Rifapentine.
EsomeprazoleThe metabolism of Esomeprazole can be increased when combined with Rifapentine.
EstazolamThe metabolism of Estazolam can be increased when combined with Rifapentine.
EstradiolThe metabolism of Estradiol can be increased when combined with Rifapentine.
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be increased when combined with Rifapentine.
EstramustineThe metabolism of Estramustine can be increased when combined with Rifapentine.
EstroneThe serum concentration of Estrone can be decreased when it is combined with Rifapentine.
Estrone sulfateThe metabolism of Estrone sulfate can be increased when combined with Rifapentine.
EszopicloneThe metabolism of Eszopiclone can be increased when combined with Rifapentine.
EthanolThe metabolism of Ethanol can be increased when combined with Rifapentine.
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be increased when combined with Rifapentine.
EthosuximideThe metabolism of Ethosuximide can be increased when combined with Rifapentine.
EthylmorphineThe metabolism of Ethylmorphine can be increased when combined with Rifapentine.
EtodolacThe metabolism of Etodolac can be increased when combined with Rifapentine.
EtonogestrelThe metabolism of Etonogestrel can be increased when combined with Rifapentine.
EtoposideThe serum concentration of Etoposide can be decreased when it is combined with Rifapentine.
EtoricoxibThe metabolism of Etoricoxib can be increased when combined with Rifapentine.
EtravirineThe metabolism of Etravirine can be increased when combined with Rifapentine.
EverolimusThe serum concentration of Everolimus can be decreased when it is combined with Rifapentine.
ExemestaneThe serum concentration of Exemestane can be decreased when it is combined with Rifapentine.
FamciclovirThe metabolism of Famciclovir can be increased when combined with Rifapentine.
FelbamateThe metabolism of Felbamate can be increased when combined with Rifapentine.
FelodipineThe metabolism of Felodipine can be increased when combined with Rifapentine.
FenofibrateThe metabolism of Fenofibrate can be increased when combined with Rifapentine.
FentanylThe serum concentration of Fentanyl can be decreased when it is combined with Rifapentine.
FesoterodineThe metabolism of Fesoterodine can be increased when combined with Rifapentine.
FinasterideThe metabolism of Finasteride can be increased when combined with Rifapentine.
FingolimodThe metabolism of Fingolimod can be increased when combined with Rifapentine.
FlibanserinThe serum concentration of Flibanserin can be decreased when it is combined with Rifapentine.
FludrocortisoneThe serum concentration of Fludrocortisone can be decreased when it is combined with Rifapentine.
FlumethasoneThe serum concentration of Flumethasone can be decreased when it is combined with Rifapentine.
FlunarizineThe metabolism of Flunarizine can be increased when combined with Rifapentine.
FlunisolideThe serum concentration of Flunisolide can be decreased when it is combined with Rifapentine.
FlunitrazepamThe metabolism of Flunitrazepam can be increased when combined with Rifapentine.
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be decreased when it is combined with Rifapentine.
FluocinonideThe serum concentration of Fluocinonide can be decreased when it is combined with Rifapentine.
FluocortoloneThe serum concentration of Fluocortolone can be decreased when it is combined with Rifapentine.
FluorometholoneThe serum concentration of Fluorometholone can be decreased when it is combined with Rifapentine.
FluorouracilThe metabolism of Fluorouracil can be increased when combined with Rifapentine.
FluoxetineThe metabolism of Fluoxetine can be increased when combined with Rifapentine.
FluprednideneThe serum concentration of Fluprednidene can be decreased when it is combined with Rifapentine.
FluprednisoloneThe serum concentration of Fluprednisolone can be decreased when it is combined with Rifapentine.
FlurandrenolideThe serum concentration of Flurandrenolide can be decreased when it is combined with Rifapentine.
FlurazepamThe metabolism of Flurazepam can be increased when combined with Rifapentine.
FlurbiprofenThe metabolism of Flurbiprofen can be increased when combined with Rifapentine.
FlutamideThe metabolism of Flutamide can be increased when combined with Rifapentine.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be decreased when it is combined with Rifapentine.
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be decreased when it is combined with Rifapentine.
FluvastatinThe metabolism of Fluvastatin can be increased when combined with Rifapentine.
FormoterolThe metabolism of Formoterol can be increased when combined with Rifapentine.
FosamprenavirThe metabolism of Fosamprenavir can be increased when combined with Rifapentine.
FosphenytoinThe metabolism of Fosphenytoin can be increased when combined with Rifapentine.
FulvestrantThe metabolism of Fulvestrant can be increased when combined with Rifapentine.
GalantamineThe metabolism of Galantamine can be increased when combined with Rifapentine.
GavestinelThe metabolism of Gavestinel can be increased when combined with Rifapentine.
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Rifapentine.
GemfibrozilThe metabolism of Gemfibrozil can be increased when combined with Rifapentine.
GliclazideThe metabolism of Gliclazide can be increased when combined with Rifapentine.
GlimepirideThe metabolism of Glimepiride can be increased when combined with Rifapentine.
GlipizideThe metabolism of Glipizide can be increased when combined with Rifapentine.
GlyburideThe metabolism of Glyburide can be increased when combined with Rifapentine.
GranisetronThe metabolism of Granisetron can be increased when combined with Rifapentine.
GrepafloxacinThe metabolism of Grepafloxacin can be increased when combined with Rifapentine.
GuanfacineThe serum concentration of Guanfacine can be decreased when it is combined with Rifapentine.
HalofantrineThe metabolism of Halofantrine can be increased when combined with Rifapentine.
HaloperidolThe metabolism of Haloperidol can be increased when combined with Rifapentine.
HalothaneThe metabolism of Halothane can be increased when combined with Rifapentine.
HexobarbitalThe metabolism of Hexobarbital can be increased when combined with Rifapentine.
Histamine PhosphateThe metabolism of Histamine Phosphate can be increased when combined with Rifapentine.
HydrocodoneThe serum concentration of Hydrocodone can be decreased when it is combined with Rifapentine.
HydrocortisoneThe serum concentration of Hydrocortisone can be decreased when it is combined with Rifapentine.
HydromorphoneThe metabolism of Hydromorphone can be increased when combined with Rifapentine.
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be increased when combined with Rifapentine.
IbrutinibThe serum concentration of Ibrutinib can be decreased when it is combined with Rifapentine.
IbuprofenThe metabolism of Ibuprofen can be increased when combined with Rifapentine.
IdarubicinThe metabolism of Idarubicin can be increased when combined with Rifapentine.
IdelalisibThe serum concentration of Idelalisib can be decreased when it is combined with Rifapentine.
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be increased when Ifosfamide is used in combination with Rifapentine.
IloperidoneThe metabolism of Iloperidone can be increased when combined with Rifapentine.
ImatinibThe serum concentration of Imatinib can be decreased when it is combined with Rifapentine.
ImipramineThe metabolism of Imipramine can be increased when combined with Rifapentine.
ImiquimodThe metabolism of Imiquimod can be increased when combined with Rifapentine.
IndacaterolThe metabolism of Indacaterol can be increased when combined with Rifapentine.
IndapamideThe metabolism of Indapamide can be increased when combined with Rifapentine.
IndinavirThe metabolism of Indinavir can be increased when combined with Rifapentine.
indisulamThe metabolism of indisulam can be increased when combined with Rifapentine.
IndomethacinThe metabolism of Indomethacin can be increased when combined with Rifapentine.
Ipratropium bromideThe metabolism of Ipratropium bromide can be increased when combined with Rifapentine.
IrbesartanThe metabolism of Irbesartan can be increased when combined with Rifapentine.
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be reduced when Irinotecan is used in combination with Rifapentine resulting in a loss in efficacy.
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Rifapentine resulting in a loss in efficacy.
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be increased when combined with Rifapentine.
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be increased when combined with Rifapentine.
IsradipineThe metabolism of Isradipine can be increased when combined with Rifapentine.
ItraconazoleThe serum concentration of Itraconazole can be decreased when it is combined with Rifapentine.
IvabradineThe serum concentration of Ivabradine can be decreased when it is combined with Rifapentine.
IvacaftorThe serum concentration of Ivacaftor can be decreased when it is combined with Rifapentine.
IvermectinThe metabolism of Ivermectin can be increased when combined with Rifapentine.
IxabepiloneThe serum concentration of Ixabepilone can be decreased when it is combined with Rifapentine.
IxazomibThe serum concentration of Ixazomib can be decreased when it is combined with Rifapentine.
KetamineThe metabolism of Ketamine can be increased when combined with Rifapentine.
KetazolamThe metabolism of Ketazolam can be increased when combined with Rifapentine.
KetobemidoneThe metabolism of Ketobemidone can be increased when combined with Rifapentine.
KetoconazoleThe metabolism of Ketoconazole can be increased when combined with Rifapentine.
KetoprofenThe metabolism of Ketoprofen can be increased when combined with Rifapentine.
LansoprazoleThe metabolism of Lansoprazole can be increased when combined with Rifapentine.
LapatinibThe serum concentration of Lapatinib can be decreased when it is combined with Rifapentine.
LaquinimodThe metabolism of Laquinimod can be increased when combined with Rifapentine.
LedipasvirThe serum concentration of Ledipasvir can be decreased when it is combined with Rifapentine.
LeflunomideThe metabolism of Leflunomide can be increased when combined with Rifapentine.
LenvatinibThe metabolism of Lenvatinib can be increased when combined with Rifapentine.
LercanidipineThe metabolism of Lercanidipine can be increased when combined with Rifapentine.
LesinuradThe metabolism of Lesinurad can be increased when combined with Rifapentine.
LetrozoleThe metabolism of Letrozole can be increased when combined with Rifapentine.
LevobupivacaineThe metabolism of Levobupivacaine can be increased when combined with Rifapentine.
LevocetirizineThe metabolism of Levocetirizine can be increased when combined with Rifapentine.
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be increased when combined with Rifapentine.
LevomilnacipranThe metabolism of Levomilnacipran can be increased when combined with Rifapentine.
LevonorgestrelThe metabolism of Levonorgestrel can be increased when combined with Rifapentine.
LevothyroxineThe metabolism of Levothyroxine can be increased when combined with Rifapentine.
LicofeloneThe metabolism of Licofelone can be increased when combined with Rifapentine.
LidocaineThe metabolism of Lidocaine can be increased when combined with Rifapentine.
LinagliptinThe serum concentration of Linagliptin can be decreased when it is combined with Rifapentine.
LisurideThe metabolism of Lisuride can be increased when combined with Rifapentine.
LomitapideThe metabolism of Lomitapide can be increased when combined with Rifapentine.
LoperamideThe metabolism of Loperamide can be increased when combined with Rifapentine.
LopinavirThe metabolism of Lopinavir can be increased when combined with Rifapentine.
LoratadineThe metabolism of Loratadine can be increased when combined with Rifapentine.
LorcaserinThe metabolism of Lorcaserin can be increased when combined with Rifapentine.
LornoxicamThe metabolism of Lornoxicam can be increased when combined with Rifapentine.
LosartanThe metabolism of Losartan can be increased when combined with Rifapentine.
LovastatinThe metabolism of Lovastatin can be increased when combined with Rifapentine.
LumefantrineThe serum concentration of Lumefantrine can be decreased when it is combined with Rifapentine.
LumiracoxibThe metabolism of Lumiracoxib can be increased when combined with Rifapentine.
LurasidoneThe serum concentration of Lurasidone can be decreased when it is combined with Rifapentine.
MacitentanThe serum concentration of Macitentan can be decreased when it is combined with Rifapentine.
MaravirocThe serum concentration of Maraviroc can be decreased when it is combined with Rifapentine.
MebendazoleThe metabolism of Mebendazole can be increased when combined with Rifapentine.
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be increased when combined with Rifapentine.
MedrysoneThe serum concentration of Medrysone can be decreased when it is combined with Rifapentine.
Mefenamic acidThe metabolism of Mefenamic acid can be increased when combined with Rifapentine.
MefloquineThe metabolism of Mefloquine can be increased when combined with Rifapentine.
MelatoninThe metabolism of Melatonin can be increased when combined with Rifapentine.
MelengestrolThe serum concentration of Melengestrol can be decreased when it is combined with Rifapentine.
MeloxicamThe metabolism of Meloxicam can be increased when combined with Rifapentine.
MephenytoinThe metabolism of Mephenytoin can be increased when combined with Rifapentine.
MestranolThe metabolism of Mestranol can be increased when combined with Rifapentine.
MethadoneThe metabolism of Methadone can be increased when combined with Rifapentine.
MethaqualoneThe metabolism of Methaqualone can be increased when combined with Rifapentine.
MethoxsalenThe metabolism of Methoxsalen can be increased when combined with Rifapentine.
MethoxyfluraneThe metabolism of Methoxyflurane can be increased when combined with Rifapentine.
MethylprednisoloneThe serum concentration of Methylprednisolone can be decreased when it is combined with Rifapentine.
MethyltestosteroneThe metabolism of Methyltestosterone can be increased when combined with Rifapentine.
MetronidazoleThe metabolism of Metronidazole can be increased when combined with Rifapentine.
MexiletineThe metabolism of Mexiletine can be increased when combined with Rifapentine.
MianserinThe metabolism of Mianserin can be increased when combined with Rifapentine.
MibefradilThe metabolism of Mibefradil can be increased when combined with Rifapentine.
MiconazoleThe metabolism of Miconazole can be increased when combined with Rifapentine.
MidazolamThe metabolism of Midazolam can be increased when combined with Rifapentine.
MifepristoneThe serum concentration of Mifepristone can be decreased when it is combined with Rifapentine.
MirabegronThe metabolism of Mirabegron can be increased when combined with Rifapentine.
MirtazapineThe metabolism of Mirtazapine can be increased when combined with Rifapentine.
MoclobemideThe metabolism of Moclobemide can be increased when combined with Rifapentine.
ModafinilThe metabolism of Modafinil can be increased when combined with Rifapentine.
MometasoneThe serum concentration of Mometasone can be decreased when it is combined with Rifapentine.
MontelukastThe metabolism of Montelukast can be increased when combined with Rifapentine.
MorphineThe metabolism of Morphine can be increased when combined with Rifapentine.
muraglitazarThe metabolism of muraglitazar can be increased when combined with Rifapentine.
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be increased when combined with Rifapentine.
NaloxegolThe serum concentration of Naloxegol can be decreased when it is combined with Rifapentine.
NaloxoneThe metabolism of Naloxone can be increased when combined with Rifapentine.
NaproxenThe metabolism of Naproxen can be increased when combined with Rifapentine.
NateglinideThe metabolism of Nateglinide can be increased when combined with Rifapentine.
NefazodoneThe metabolism of Nefazodone can be increased when combined with Rifapentine.
NelfinavirThe metabolism of Nelfinavir can be increased when combined with Rifapentine.
NetupitantThe serum concentration of Netupitant can be decreased when it is combined with Rifapentine.
NevirapineThe metabolism of Nevirapine can be increased when combined with Rifapentine.
NicardipineThe metabolism of Nicardipine can be increased when combined with Rifapentine.
NiclosamideThe metabolism of Niclosamide can be increased when combined with Rifapentine.
NicotineThe metabolism of Nicotine can be increased when combined with Rifapentine.
NifedipineThe serum concentration of Nifedipine can be decreased when it is combined with Rifapentine.
NilotinibThe serum concentration of Nilotinib can be decreased when it is combined with Rifapentine.
NilvadipineThe metabolism of Nilvadipine can be increased when combined with Rifapentine.
NimodipineThe serum concentration of Nimodipine can be decreased when it is combined with Rifapentine.
NintedanibThe serum concentration of Nintedanib can be decreased when it is combined with Rifapentine.
NisoldipineThe serum concentration of Nisoldipine can be decreased when it is combined with Rifapentine.
NitrazepamThe metabolism of Nitrazepam can be increased when combined with Rifapentine.
NitrendipineThe metabolism of Nitrendipine can be increased when combined with Rifapentine.
NorethisteroneThe metabolism of Norethisterone can be increased when combined with Rifapentine.
NorgestrelThe metabolism of Norgestrel can be increased when combined with Rifapentine.
NortriptylineThe metabolism of Nortriptyline can be increased when combined with Rifapentine.
OlaparibThe serum concentration of Olaparib can be decreased when it is combined with Rifapentine.
OlodaterolThe metabolism of Olodaterol can be increased when combined with Rifapentine.
OlopatadineThe metabolism of Olopatadine can be increased when combined with Rifapentine.
OmbitasvirThe metabolism of Ombitasvir can be increased when combined with Rifapentine.
OmeprazoleThe metabolism of Omeprazole can be increased when combined with Rifapentine.
OndansetronThe metabolism of Ondansetron can be increased when combined with Rifapentine.
OrphenadrineThe metabolism of Orphenadrine can be increased when combined with Rifapentine.
OsimertinibThe serum concentration of Osimertinib can be decreased when it is combined with Rifapentine.
OspemifeneThe metabolism of Ospemifene can be increased when combined with Rifapentine.
OxaprozinThe metabolism of Oxaprozin can be increased when combined with Rifapentine.
OxazepamThe metabolism of Oxazepam can be increased when combined with Rifapentine.
OxybutyninThe metabolism of Oxybutynin can be increased when combined with Rifapentine.
OxycodoneThe metabolism of Oxycodone can be increased when combined with Rifapentine.
OxymorphoneThe metabolism of Oxymorphone can be increased when combined with Rifapentine.
PaclitaxelThe metabolism of Paclitaxel can be increased when combined with Rifapentine.
PalbociclibThe serum concentration of Palbociclib can be decreased when it is combined with Rifapentine.
PalonosetronThe metabolism of Palonosetron can be increased when combined with Rifapentine.
PanobinostatThe serum concentration of Panobinostat can be decreased when it is combined with Rifapentine.
PantoprazoleThe metabolism of Pantoprazole can be increased when combined with Rifapentine.
ParamethadioneThe metabolism of Paramethadione can be increased when combined with Rifapentine.
ParamethasoneThe serum concentration of Paramethasone can be decreased when it is combined with Rifapentine.
ParecoxibThe metabolism of Parecoxib can be increased when combined with Rifapentine.
ParicalcitolThe metabolism of Paricalcitol can be increased when combined with Rifapentine.
ParitaprevirThe metabolism of Paritaprevir can be increased when combined with Rifapentine.
PazopanibThe serum concentration of Pazopanib can be decreased when it is combined with Rifapentine.
PentamidineThe metabolism of Pentamidine can be increased when combined with Rifapentine.
PerampanelThe serum concentration of Perampanel can be decreased when it is combined with Rifapentine.
PergolideThe metabolism of Pergolide can be increased when combined with Rifapentine.
PerhexilineThe metabolism of Perhexiline can be increased when combined with Rifapentine.
PermethrinThe metabolism of Permethrin can be increased when combined with Rifapentine.
PerphenazineThe metabolism of Perphenazine can be increased when combined with Rifapentine.
PethidineThe metabolism of Pethidine can be increased when combined with Rifapentine.
PhenacetinThe metabolism of Phenacetin can be increased when combined with Rifapentine.
PhenobarbitalThe metabolism of Phenobarbital can be increased when combined with Rifapentine.
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be increased when combined with Rifapentine.
PhenprocoumonThe metabolism of Phenprocoumon can be increased when combined with Rifapentine.
PhenylbutazoneThe metabolism of Phenylbutazone can be increased when combined with Rifapentine.
PhenytoinThe metabolism of Phenytoin can be increased when combined with Rifapentine.
Picosulfuric acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Rifapentine.
PilocarpineThe metabolism of Pilocarpine can be increased when combined with Rifapentine.
PimecrolimusThe metabolism of Pimecrolimus can be increased when combined with Rifapentine.
PimozideThe metabolism of Pimozide can be increased when combined with Rifapentine.
PinacidilThe metabolism of Pinacidil can be increased when combined with Rifapentine.
PioglitazoneThe metabolism of Pioglitazone can be increased when combined with Rifapentine.
PipotiazineThe metabolism of Pipotiazine can be increased when combined with Rifapentine.
PiroxicamThe metabolism of Piroxicam can be increased when combined with Rifapentine.
PitavastatinThe metabolism of Pitavastatin can be increased when combined with Rifapentine.
PodofiloxThe metabolism of Podofilox can be increased when combined with Rifapentine.
PomalidomideThe metabolism of Pomalidomide can be increased when combined with Rifapentine.
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with Rifapentine.
PosaconazoleThe metabolism of Posaconazole can be increased when combined with Rifapentine.
PrasugrelThe metabolism of Prasugrel can be increased when combined with Rifapentine.
PravastatinThe metabolism of Pravastatin can be increased when combined with Rifapentine.
PrazepamThe metabolism of Prazepam can be increased when combined with Rifapentine.
PraziquantelThe serum concentration of Praziquantel can be decreased when it is combined with Rifapentine.
PrednicarbateThe serum concentration of Prednicarbate can be decreased when it is combined with Rifapentine.
PrednisoloneThe serum concentration of Prednisolone can be decreased when it is combined with Rifapentine.
PrednisoneThe serum concentration of Prednisone can be decreased when it is combined with Rifapentine.
PregnenoloneThe serum concentration of Pregnenolone can be decreased when it is combined with Rifapentine.
PrimaquineThe metabolism of Primaquine can be increased when combined with Rifapentine.
ProchlorperazineThe metabolism of Prochlorperazine can be increased when combined with Rifapentine.
ProgesteroneThe metabolism of Progesterone can be increased when combined with Rifapentine.
ProguanilThe metabolism of Proguanil can be increased when combined with Rifapentine.
PromazineThe metabolism of Promazine can be increased when combined with Rifapentine.
PropafenoneThe serum concentration of Propafenone can be decreased when it is combined with Rifapentine.
PropofolThe metabolism of Propofol can be increased when combined with Rifapentine.
PropranololThe metabolism of Propranolol can be increased when combined with Rifapentine.
PyrazinamideThe metabolism of Pyrazinamide can be increased when combined with Rifapentine.
QuazepamThe metabolism of Quazepam can be increased when combined with Rifapentine.
QuetiapineThe serum concentration of Quetiapine can be decreased when it is combined with Rifapentine.
QuinacrineThe metabolism of Quinacrine can be increased when combined with Rifapentine.
QuinidineThe metabolism of Quinidine can be increased when combined with Rifapentine.
QuinineThe metabolism of Quinine can be increased when combined with Rifapentine.
RabeprazoleThe metabolism of Rabeprazole can be increased when combined with Rifapentine.
RaloxifeneThe metabolism of Raloxifene can be increased when combined with Rifapentine.
RaltegravirThe serum concentration of Raltegravir can be increased when it is combined with Rifapentine.
RamelteonThe metabolism of Ramelteon can be increased when combined with Rifapentine.
RanolazineThe serum concentration of Ranolazine can be decreased when it is combined with Rifapentine.
ReboxetineThe metabolism of Reboxetine can be increased when combined with Rifapentine.
RegorafenibThe serum concentration of Regorafenib can be decreased when it is combined with Rifapentine.
RepaglinideThe metabolism of Repaglinide can be increased when combined with Rifapentine.
RetapamulinThe metabolism of Retapamulin can be increased when combined with Rifapentine.
RifabutinThe metabolism of Rifabutin can be increased when combined with Rifapentine.
RifampicinThe metabolism of Rifampicin can be increased when combined with Rifapentine.
RilpivirineThe metabolism of Rilpivirine can be increased when combined with Rifapentine.
RimexoloneThe serum concentration of Rimexolone can be decreased when it is combined with Rifapentine.
RimonabantThe metabolism of Rimonabant can be increased when combined with Rifapentine.
RiociguatThe metabolism of Riociguat can be increased when combined with Rifapentine.
RisperidoneThe metabolism of Risperidone can be increased when combined with Rifapentine.
RitonavirThe metabolism of Ritonavir can be increased when combined with Rifapentine.
RivaroxabanThe serum concentration of Rivaroxaban can be decreased when it is combined with Rifapentine.
RofecoxibThe metabolism of Rofecoxib can be increased when combined with Rifapentine.
RoflumilastThe serum concentration of Roflumilast can be decreased when it is combined with Rifapentine.
RolapitantThe serum concentration of Rolapitant can be decreased when it is combined with Rifapentine.
RomidepsinThe serum concentration of Romidepsin can be decreased when it is combined with Rifapentine.
RopiniroleThe metabolism of Ropinirole can be increased when combined with Rifapentine.
RopivacaineThe metabolism of Ropivacaine can be increased when combined with Rifapentine.
RosiglitazoneThe metabolism of Rosiglitazone can be increased when combined with Rifapentine.
RosuvastatinThe metabolism of Rosuvastatin can be increased when combined with Rifapentine.
RotigotineThe metabolism of Rotigotine can be increased when combined with Rifapentine.
RoxithromycinThe metabolism of Roxithromycin can be increased when combined with Rifapentine.
RuxolitinibThe metabolism of Ruxolitinib can be increased when combined with Rifapentine.
Salicylic acidThe metabolism of Salicylic acid can be increased when combined with Rifapentine.
SalmeterolThe metabolism of Salmeterol can be increased when combined with Rifapentine.
SaquinavirThe metabolism of Saquinavir can be increased when combined with Rifapentine.
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Rifapentine.
SelegilineThe metabolism of Selegiline can be increased when combined with Rifapentine.
SelexipagThe metabolism of Selexipag can be increased when combined with Rifapentine.
SeratrodastThe metabolism of Seratrodast can be increased when combined with Rifapentine.
SertindoleThe metabolism of Sertindole can be increased when combined with Rifapentine.
SertralineThe metabolism of Sertraline can be increased when combined with Rifapentine.
SevofluraneThe metabolism of Sevoflurane can be increased when combined with Rifapentine.
SibutramineThe metabolism of Sibutramine can be increased when combined with Rifapentine.
SildenafilThe metabolism of Sildenafil can be increased when combined with Rifapentine.
SilodosinThe metabolism of Silodosin can be increased when combined with Rifapentine.
SimeprevirThe serum concentration of Simeprevir can be decreased when it is combined with Rifapentine.
SimvastatinThe metabolism of Simvastatin can be increased when combined with Rifapentine.
SirolimusThe metabolism of Sirolimus can be increased when combined with Rifapentine.
SitagliptinThe metabolism of Sitagliptin can be increased when combined with Rifapentine.
SitaxentanThe metabolism of Sitaxentan can be increased when combined with Rifapentine.
SofosbuvirThe serum concentration of Sofosbuvir can be decreased when it is combined with Rifapentine.
SolifenacinThe metabolism of Solifenacin can be increased when combined with Rifapentine.
SonidegibThe serum concentration of Sonidegib can be decreased when it is combined with Rifapentine.
SorafenibThe serum concentration of Sorafenib can be decreased when it is combined with Rifapentine.
SpiramycinThe metabolism of Spiramycin can be increased when combined with Rifapentine.
SufentanilThe metabolism of Sufentanil can be increased when combined with Rifapentine.
SulfadiazineThe metabolism of Sulfadiazine can be increased when combined with Rifapentine.
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be increased when combined with Rifapentine.
SulfamoxoleThe metabolism of Sulfamoxole can be increased when combined with Rifapentine.
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be increased when combined with Rifapentine.
SulfisoxazoleThe metabolism of Sulfisoxazole can be increased when combined with Rifapentine.
SunitinibThe serum concentration of Sunitinib can be decreased when it is combined with Rifapentine.
SuprofenThe metabolism of Suprofen can be increased when combined with Rifapentine.
SuvorexantThe serum concentration of Suvorexant can be decreased when it is combined with Rifapentine.
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be increased when combined with Rifapentine.
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be increased when combined with Rifapentine.
TacrolimusThe metabolism of Tacrolimus can be increased when combined with Rifapentine.
TadalafilThe serum concentration of Tadalafil can be decreased when it is combined with Rifapentine.
TamoxifenThe metabolism of Tamoxifen can be increased when combined with Rifapentine.
TamsulosinThe metabolism of Tamsulosin can be increased when combined with Rifapentine.
TapentadolThe metabolism of Tapentadol can be increased when combined with Rifapentine.
TasimelteonThe serum concentration of Tasimelteon can be decreased when it is combined with Rifapentine.
TasosartanThe metabolism of Tasosartan can be increased when combined with Rifapentine.
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be increased when combined with Rifapentine.
TazaroteneThe metabolism of Tazarotene can be increased when combined with Rifapentine.
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Rifapentine.
TelithromycinThe metabolism of Telithromycin can be increased when combined with Rifapentine.
TemazepamThe metabolism of Temazepam can be increased when combined with Rifapentine.
TemsirolimusThe metabolism of Temsirolimus can be increased when combined with Rifapentine.
TeniposideThe metabolism of Teniposide can be increased when combined with Rifapentine.
TenoxicamThe metabolism of Tenoxicam can be increased when combined with Rifapentine.
TerbinafineThe metabolism of Terbinafine can be increased when combined with Rifapentine.
TerfenadineThe metabolism of Terfenadine can be increased when combined with Rifapentine.
TesmilifeneThe metabolism of Tesmilifene can be increased when combined with Rifapentine.
TestosteroneThe metabolism of Testosterone can be increased when combined with Rifapentine.
TetracyclineThe metabolism of Tetracycline can be increased when combined with Rifapentine.
ThalidomideThe metabolism of Thalidomide can be increased when combined with Rifapentine.
TheophyllineThe metabolism of Theophylline can be increased when combined with Rifapentine.
ThiamylalThe metabolism of Thiamylal can be increased when combined with Rifapentine.
ThiotepaThe metabolism of Thiotepa can be increased when combined with Rifapentine.
TiagabineThe metabolism of Tiagabine can be increased when combined with Rifapentine.
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Rifapentine resulting in a loss in efficacy.
TiclopidineThe metabolism of Ticlopidine can be increased when combined with Rifapentine.
TinidazoleThe metabolism of Tinidazole can be increased when combined with Rifapentine.
TiotropiumThe metabolism of Tiotropium can be increased when combined with Rifapentine.
TipranavirThe metabolism of Tipranavir can be increased when combined with Rifapentine.
TixocortolThe serum concentration of Tixocortol can be decreased when it is combined with Rifapentine.
TofacitinibThe serum concentration of Tofacitinib can be decreased when it is combined with Rifapentine.
TolbutamideThe metabolism of Tolbutamide can be increased when combined with Rifapentine.
TolterodineThe metabolism of Tolterodine can be increased when combined with Rifapentine.
TolvaptanThe serum concentration of Tolvaptan can be decreased when it is combined with Rifapentine.
TorasemideThe metabolism of Torasemide can be increased when combined with Rifapentine.
ToremifeneThe serum concentration of Toremifene can be decreased when it is combined with Rifapentine.
TrabectedinThe serum concentration of Trabectedin can be decreased when it is combined with Rifapentine.
TramadolThe metabolism of Tramadol can be increased when combined with Rifapentine.
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be increased when combined with Rifapentine.
TrazodoneThe metabolism of Trazodone can be increased when combined with Rifapentine.
TreprostinilThe serum concentration of Treprostinil can be decreased when it is combined with Rifapentine.
TretinoinThe metabolism of Tretinoin can be increased when combined with Rifapentine.
TriamcinoloneThe serum concentration of Triamcinolone can be decreased when it is combined with Rifapentine.
TriazolamThe metabolism of Triazolam can be increased when combined with Rifapentine.
TrimethadioneThe metabolism of Trimethadione can be increased when combined with Rifapentine.
TrimethoprimThe metabolism of Trimethoprim can be increased when combined with Rifapentine.
TrimipramineThe metabolism of Trimipramine can be increased when combined with Rifapentine.
TroglitazoneThe metabolism of Troglitazone can be increased when combined with Rifapentine.
TroleandomycinThe metabolism of Troleandomycin can be increased when combined with Rifapentine.
UdenafilThe metabolism of Udenafil can be increased when combined with Rifapentine.
UlipristalThe serum concentration of Ulipristal can be decreased when it is combined with Rifapentine.
ValdecoxibThe metabolism of Valdecoxib can be increased when combined with Rifapentine.
Valproic AcidThe metabolism of Valproic Acid can be increased when combined with Rifapentine.
ValsartanThe metabolism of Valsartan can be increased when combined with Rifapentine.
VandetanibThe serum concentration of Vandetanib can be decreased when it is combined with Rifapentine.
VanoxerineThe metabolism of Vanoxerine can be increased when combined with Rifapentine.
VardenafilThe metabolism of Vardenafil can be increased when combined with Rifapentine.
VemurafenibThe serum concentration of Vemurafenib can be decreased when it is combined with Rifapentine.
VenlafaxineThe metabolism of Venlafaxine can be increased when combined with Rifapentine.
VerapamilThe metabolism of Verapamil can be increased when combined with Rifapentine.
VicrivirocThe metabolism of Vicriviroc can be increased when combined with Rifapentine.
VilanterolThe metabolism of Vilanterol can be increased when combined with Rifapentine.
VilazodoneThe serum concentration of Vilazodone can be decreased when it is combined with Rifapentine.
VinblastineThe metabolism of Vinblastine can be increased when combined with Rifapentine.
VincristineThe serum concentration of Vincristine can be decreased when it is combined with Rifapentine.
VindesineThe metabolism of Vindesine can be increased when combined with Rifapentine.
VinorelbineThe metabolism of Vinorelbine can be increased when combined with Rifapentine.
VismodegibThe metabolism of Vismodegib can be increased when combined with Rifapentine.
VorapaxarThe serum concentration of Vorapaxar can be decreased when it is combined with Rifapentine.
VoriconazoleThe metabolism of Voriconazole can be increased when combined with Rifapentine.
VortioxetineThe serum concentration of Vortioxetine can be decreased when it is combined with Rifapentine.
WarfarinThe metabolism of Warfarin can be increased when combined with Rifapentine.
XimelagatranThe metabolism of Ximelagatran can be increased when combined with Rifapentine.
YohimbineThe metabolism of Yohimbine can be increased when combined with Rifapentine.
ZafirlukastThe metabolism of Zafirlukast can be increased when combined with Rifapentine.
ZalcitabineThe metabolism of Zalcitabine can be increased when combined with Rifapentine.
ZaleplonThe serum concentration of Zaleplon can be decreased when it is combined with Rifapentine.
ZaltoprofenThe metabolism of Zaltoprofen can be increased when combined with Rifapentine.
ZidovudineThe metabolism of Zidovudine can be increased when combined with Rifapentine.
ZileutonThe metabolism of Zileuton can be increased when combined with Rifapentine.
ZiprasidoneThe metabolism of Ziprasidone can be increased when combined with Rifapentine.
ZolpidemThe metabolism of Zolpidem can be increased when combined with Rifapentine.
ZomepiracThe metabolism of Zomepirac can be increased when combined with Rifapentine.
ZonisamideThe metabolism of Zonisamide can be increased when combined with Rifapentine.
ZopicloneThe metabolism of Zopiclone can be increased when combined with Rifapentine.
ZuclopenthixolThe serum concentration of Zuclopenthixol can be decreased when it is combined with Rifapentine.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Mycobacterium tuberculosis
Pharmacological action
yes
Actions
inhibitor
General Function:
Transcription
Specific Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Gene Name:
rpoC
Uniprot ID:
P0A674
Molecular Weight:
146771.0 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Williams DL, Spring L, Collins L, Miller LP, Heifets LB, Gangadharam PR, Gillis TP: Contribution of rpoB mutations to development of rifamycin cross-resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 1998 Jul;42(7):1853-7. [PubMed:9661035 ]
  4. Tupin A, Gualtieri M, Roquet-Baneres F, Morichaud Z, Brodolin K, Leonetti JP: Resistance to rifampicin: at the crossroads between ecological, genomic and medical concerns. Int J Antimicrob Agents. 2010 Jun;35(6):519-23. doi: 10.1016/j.ijantimicag.2009.12.017. Epub 2010 Feb 24. [PubMed:20185278 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Monooxygenase activity
Specific Function:
Exhibits low testosterone 6-beta-hydroxylase activity.
Gene Name:
CYP3A43
Uniprot ID:
Q9HB55
Molecular Weight:
57669.21 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Comments
comments powered by Disqus
Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23