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Identification
NameEstazolam
Accession NumberDB01215  (APRD00955)
Typesmall molecule
Groupsapproved, illicit
Description

A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam. [PubChem]

Structure
Thumb
Synonyms
SynonymLanguageCode
8-chloro-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepineNot AvailableNot Available
SaltsNot Available
Brand names
NameCompany
EsilganNot Available
EurodinNot Available
NuctalonNot Available
ProSomNot Available
Brand mixturesNot Available
CategoriesNot Available
CAS number29975-16-4
WeightAverage: 294.738
Monoisotopic: 294.067224079
Chemical FormulaC16H11ClN4
InChI KeyInChIKey=CDCHDCWJMGXXRH-UHFFFAOYSA-N
InChI
InChI=1S/C16H11ClN4/c17-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)18-9-15-20-19-10-21(14)15/h1-8,10H,9H2
IUPAC Name
12-chloro-9-phenyl-2,4,5,8-tetraazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),3,5,8,11,13-hexaene
SMILES
ClC1=CC2=C(C=C1)N1C=NN=C1CN=C2C1=CC=CC=C1
Mass SpecNot Available
Taxonomy
KingdomOrganic Compounds
SuperclassHeterocyclic Compounds
ClassBenzodiazepines
SubclassNot Available
Direct parentBenzodiazepines
Alternative parentsChlorobenzenes; Aryl Chlorides; Triazoles; Polyamines; Organochlorides
Substituentschlorobenzene; aryl halide; benzene; aryl chloride; 1,2,4-triazole; azole; polyamine; organochloride; organohalogen; organonitrogen compound
Classification descriptionThis compound belongs to the benzodiazepines. These are organic compounds containing a benzene ring fused to either isomers of diazepine(unsaturated seven-member heterocycle with two nitrogen atoms replacing two carbon atoms).
Pharmacology
IndicationFor the short-term management of insomnia characterized by difficulty in falling asleep, frequent nocturnal awakenings, and/or early morning awakenings.
PharmacodynamicsEstazolam, a triazolobenzodiazepine derivative, is an oral hypnotic agent with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam.
Mechanism of actionBenzodiazepines bind nonspecifically to benzodiazepine receptors, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.
AbsorptionTablets have been found to be equivalent in absorption to an orally administered solution of estazolam. In healthy subjects who received up to three times the recommended dose, peak estazolam plasma concentrations occurred within two hours after dosing (range 0.5 to 6.0 hours) and were proportional to the administered dose, suggesting linear pharmacokinetics over the dosage range tested.
Volume of distributionNot Available
Protein binding93% protein bound, independant of concentration.
Metabolism

Extensively metabolized in the liver. In vitro studies with human liver microsomes indicate that the biotransformation of estazolam to the major circulating metabolite 4-hydroxy-estazolam is mediated by cytochrome P450 3A (CYP3A).

SubstrateEnzymesProduct
Estazolam
    4-hydroxy-estazolamDetails
    Route of eliminationEstazolam is extensively metabolized. The elimination of the parent drug takes place via hepatic metabolism of estazolam to hydroxylated and other metabolites that are eliminated largely in the urine both free and conjugated. Less than 5% of a 2 mg dose of estazolam was excreted unchanged in the urine, with only 4% of the dose appearing in the feces. Radiolabel mass balance studies indicate that the main route of excretion is via the kidneys. After 5 days, 87% of the administered radioactivity was excreted in human urine. Less than 4% of the dose was excreted unchanged.
    Half lifeThe range of estimates for the mean elimination half-life of estazolam varies from 10 to 24 hours.
    ClearanceNot Available
    ToxicitySymptoms of overdose include confusion, depressed breathing, drowsiness and eventually coma, lack of coordination, and slurred speech.
    Affected organisms
    • Humans and other mammals
    PathwaysNot Available
    SNP Mediated EffectsNot Available
    SNP Mediated Adverse Drug ReactionsNot Available
    ADMET
    Predicted ADMET features
    Property Value Probability
    Human Intestinal Absorption + 1.0
    Blood Brain Barrier + 0.9796
    Caco-2 permeable + 0.8427
    P-glycoprotein substrate Non-substrate 0.5939
    P-glycoprotein inhibitor I Non-inhibitor 0.7883
    P-glycoprotein inhibitor II Inhibitor 0.7786
    Renal organic cation transporter Inhibitor 0.7784
    CYP450 2C9 substrate Non-substrate 0.8367
    CYP450 2D6 substrate Non-substrate 0.9081
    CYP450 3A4 substrate Substrate 0.674
    CYP450 1A2 substrate Inhibitor 0.8989
    CYP450 2C9 substrate Inhibitor 0.822
    CYP450 2D6 substrate Non-inhibitor 0.8586
    CYP450 2C19 substrate Inhibitor 0.6571
    CYP450 3A4 substrate Non-inhibitor 0.6818
    CYP450 inhibitory promiscuity High CYP Inhibitory Promiscuity 0.8676
    Ames test Non AMES toxic 0.9132
    Carcinogenicity Non-carcinogens 0.7126
    Biodegradation Not ready biodegradable 1.0
    Rat acute toxicity 2.0584 LD50, mol/kg Not applicable
    hERG inhibition (predictor I) Weak inhibitor 0.9752
    hERG inhibition (predictor II) Non-inhibitor 0.8944
    Pharmacoeconomics
    Manufacturers
    • Par pharmaceutical inc
    • Teva pharmaceuticals usa inc
    • Watson laboratories inc
    • Abbott laboratories pharmaceutical products div
    Packagers
    Dosage forms
    FormRouteStrength
    TabletOral
    Prices
    Unit descriptionCostUnit
    Prosom 2 mg tablet1.71USDtablet
    Prosom 1 mg tablet1.53USDtablet
    Estazolam 2 mg tablet0.96USDtablet
    Estazolam 1 mg tablet0.86USDtablet
    DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
    PatentsNot Available
    Properties
    Statesolid
    Experimental Properties
    PropertyValueSource
    melting point228.5 °CPhysProp
    water solubilityPractically insoluble (1.5 mg/L)Not Available
    logP4.7Not Available
    Predicted Properties
    PropertyValueSource
    water solubility4.23e-02 g/lALOGPS
    logP1.72ALOGPS
    logP2.09ChemAxon
    logS-3.8ALOGPS
    pKa (strongest acidic)18.4ChemAxon
    pKa (strongest basic)4.97ChemAxon
    physiological charge0ChemAxon
    hydrogen acceptor count3ChemAxon
    hydrogen donor count0ChemAxon
    polar surface area43.07ChemAxon
    rotatable bond count1ChemAxon
    refractivity94.44ChemAxon
    polarizability29.83ChemAxon
    number of rings4ChemAxon
    bioavailability1ChemAxon
    rule of fiveYesChemAxon
    Ghose filterYesChemAxon
    Veber's ruleNoChemAxon
    MDDR-like ruleNoChemAxon
    Spectra
    SpectraNot Available
    References
    Synthesis ReferenceNot Available
    General Reference
    1. Watanabe S, Ohta H, Sakurai Y, Takao K, Ueki S: [Electroencephalographic effects of 450191-S and its metabolites in rabbits with chronic electrode implants] Nippon Yakurigaku Zasshi. 1986 Jul;88(1):19-32. Pubmed
    2. Oishi R, Nishibori M, Itoh Y, Saeki K: Diazepam-induced decrease in histamine turnover in mouse brain. Eur J Pharmacol. 1986 May 27;124(3):337-42. Pubmed
    3. Usami N, Yamamoto T, Shintani S, Ishikura S, Higaki Y, Katagiri Y, Hara A: Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines. Biol Pharm Bull. 2002 Apr;25(4):441-5. Pubmed
    External Links
    ResourceLink
    KEGG DrugD00311
    PubChem Compound3261
    PubChem Substance46507430
    ChemSpider3146
    BindingDB50240450
    ChEBI4858
    ChEMBLCHEMBL1201169
    Therapeutic Targets DatabaseDAP000930
    PharmGKBPA449502
    Drug Product Database2016060
    RxListhttp://www.rxlist.com/cgi/generic2/estaz.htm
    Drugs.comhttp://www.drugs.com/cdi/estazolam.html
    PDRhealthhttp://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/pro1359.shtml
    WikipediaEstazolam
    ATC CodesN05CD04
    AHFS CodesNot Available
    PDB EntriesNot Available
    FDA labelNot Available
    MSDSNot Available
    Interactions
    Drug Interactions
    Drug
    CimetidineCimetidine may increase the effect of the benzodiazepine, estazolam.
    ClozapineIncreased risk of toxicity
    FluconazoleFluconazole may increase the effect of the benzodiazepine, estazolam.
    IndinavirThe protease inhibitor, indinavir, may increase the effect of the benzodiazepine, estazolam.
    ItraconazoleItraconazole may increase the effect of the benzodiazepine, estazolam.
    KavaKava may increase the effect of the benzodiazepine, estazolam.
    KetoconazoleKetoconazole may increase the effect of the benzodiazepine, estazolam.
    NelfinavirThe protease inhibitor, nelfinavir, may increase the effect of the benzodiazepine, estazolam.
    OmeprazoleOmeprazole may increase the effect of the benzodiazepine, estazolam.
    RitonavirThe protease inhibitor, ritonavir, may increase the effect of the benzodiazepine, estazolam.
    SaquinavirThe protease inhibitor, saquinavir, may increase the effect of the benzodiazepine, estazolam.
    TipranavirTipranavir may decrease the metabolism and clearance of Estazolam. Consider alternate therapy or monitor for Estazolam toxic effects if Tipranavir is initiated or dose increased.
    TriprolidineThe CNS depressants, Triprolidine and Estazolam, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
    VoriconazoleVoriconazole may increase the serum concentration of estazolam by decreasing its metabolism. Monitor for estazolam toxicity if voriconazole is initiated or dose increased.
    Food Interactions
    • Avoid alcohol.
    • Take without regard to meals.

    1. Gamma-aminobutyric acid receptor subunit alpha-1

    Kind: protein

    Organism: Human

    Pharmacological action: yes

    Actions: potentiator

    Components

    Name UniProt ID Details
    Gamma-aminobutyric acid receptor subunit alpha-1 P14867 Details

    References:

    1. Braestrup C, Squires RF: Pharmacological characterization of benzodiazepine receptors in the brain. Eur J Pharmacol. 1978 Apr 1;48(3):263-70. Pubmed
    2. Miller LG, Greenblatt DJ, Barnhill JG, Deutsch SI, Shader RI, Paul SM: Benzodiazepine receptor binding of triazolobenzodiazepines in vivo: increased receptor number with low-dose alprazolam. J Neurochem. 1987 Nov;49(5):1595-601. Pubmed

    2. Gamma-aminobutyric acid receptor subunit alpha-2

    Kind: protein

    Organism: Human

    Pharmacological action: yes

    Actions: potentiator

    Components

    Name UniProt ID Details
    Gamma-aminobutyric acid receptor subunit alpha-2 P47869 Details

    References:

    1. Braestrup C, Squires RF: Pharmacological characterization of benzodiazepine receptors in the brain. Eur J Pharmacol. 1978 Apr 1;48(3):263-70. Pubmed
    2. Miller LG, Greenblatt DJ, Barnhill JG, Deutsch SI, Shader RI, Paul SM: Benzodiazepine receptor binding of triazolobenzodiazepines in vivo: increased receptor number with low-dose alprazolam. J Neurochem. 1987 Nov;49(5):1595-601. Pubmed

    3. Gamma-aminobutyric acid receptor subunit alpha-3

    Kind: protein

    Organism: Human

    Pharmacological action: yes

    Actions: potentiator

    Components

    Name UniProt ID Details
    Gamma-aminobutyric acid receptor subunit alpha-3 P34903 Details

    References:

    1. Braestrup C, Squires RF: Pharmacological characterization of benzodiazepine receptors in the brain. Eur J Pharmacol. 1978 Apr 1;48(3):263-70. Pubmed
    2. Miller LG, Greenblatt DJ, Barnhill JG, Deutsch SI, Shader RI, Paul SM: Benzodiazepine receptor binding of triazolobenzodiazepines in vivo: increased receptor number with low-dose alprazolam. J Neurochem. 1987 Nov;49(5):1595-601. Pubmed

    4. Gamma-aminobutyric acid receptor subunit alpha-5

    Kind: protein

    Organism: Human

    Pharmacological action: yes

    Actions: potentiator

    Components

    Name UniProt ID Details
    Gamma-aminobutyric acid receptor subunit alpha-5 P31644 Details

    References:

    1. Braestrup C, Squires RF: Pharmacological characterization of benzodiazepine receptors in the brain. Eur J Pharmacol. 1978 Apr 1;48(3):263-70. Pubmed
    2. Miller LG, Greenblatt DJ, Barnhill JG, Deutsch SI, Shader RI, Paul SM: Benzodiazepine receptor binding of triazolobenzodiazepines in vivo: increased receptor number with low-dose alprazolam. J Neurochem. 1987 Nov;49(5):1595-601. Pubmed

    5. Gamma-aminobutyric acid receptor subunit gamma-1

    Kind: protein

    Organism: Human

    Pharmacological action: yes

    Actions: potentiator

    Components

    Name UniProt ID Details
    Gamma-aminobutyric acid receptor subunit gamma-1 Q8N1C3 Details

    References:

    1. Braestrup C, Squires RF: Pharmacological characterization of benzodiazepine receptors in the brain. Eur J Pharmacol. 1978 Apr 1;48(3):263-70. Pubmed
    2. Miller LG, Greenblatt DJ, Barnhill JG, Deutsch SI, Shader RI, Paul SM: Benzodiazepine receptor binding of triazolobenzodiazepines in vivo: increased receptor number with low-dose alprazolam. J Neurochem. 1987 Nov;49(5):1595-601. Pubmed

    6. Gamma-aminobutyric acid receptor subunit gamma-2

    Kind: protein

    Organism: Human

    Pharmacological action: yes

    Actions: potentiator

    Components

    Name UniProt ID Details
    Gamma-aminobutyric acid receptor subunit gamma-2 P18507 Details

    References:

    1. Braestrup C, Squires RF: Pharmacological characterization of benzodiazepine receptors in the brain. Eur J Pharmacol. 1978 Apr 1;48(3):263-70. Pubmed
    2. Miller LG, Greenblatt DJ, Barnhill JG, Deutsch SI, Shader RI, Paul SM: Benzodiazepine receptor binding of triazolobenzodiazepines in vivo: increased receptor number with low-dose alprazolam. J Neurochem. 1987 Nov;49(5):1595-601. Pubmed

    7. Gamma-aminobutyric acid receptor subunit gamma-3

    Kind: protein

    Organism: Human

    Pharmacological action: yes

    Actions: potentiator

    Components

    Name UniProt ID Details
    Gamma-aminobutyric acid receptor subunit gamma-3 Q99928 Details

    References:

    1. Braestrup C, Squires RF: Pharmacological characterization of benzodiazepine receptors in the brain. Eur J Pharmacol. 1978 Apr 1;48(3):263-70. Pubmed
    2. Miller LG, Greenblatt DJ, Barnhill JG, Deutsch SI, Shader RI, Paul SM: Benzodiazepine receptor binding of triazolobenzodiazepines in vivo: increased receptor number with low-dose alprazolam. J Neurochem. 1987 Nov;49(5):1595-601. Pubmed

    8. Gamma-aminobutyric acid receptor subunit beta-1

    Kind: protein

    Organism: Human

    Pharmacological action: yes

    Actions: potentiator

    Components

    Name UniProt ID Details
    Gamma-aminobutyric acid receptor subunit beta-1 P18505 Details

    References:

    1. Braestrup C, Squires RF: Pharmacological characterization of benzodiazepine receptors in the brain. Eur J Pharmacol. 1978 Apr 1;48(3):263-70. Pubmed
    2. Miller LG, Greenblatt DJ, Barnhill JG, Deutsch SI, Shader RI, Paul SM: Benzodiazepine receptor binding of triazolobenzodiazepines in vivo: increased receptor number with low-dose alprazolam. J Neurochem. 1987 Nov;49(5):1595-601. Pubmed

    9. Gamma-aminobutyric acid receptor subunit beta-2

    Kind: protein

    Organism: Human

    Pharmacological action: yes

    Actions: potentiator

    Components

    Name UniProt ID Details
    Gamma-aminobutyric acid receptor subunit beta-2 P47870 Details

    References:

    1. Braestrup C, Squires RF: Pharmacological characterization of benzodiazepine receptors in the brain. Eur J Pharmacol. 1978 Apr 1;48(3):263-70. Pubmed
    2. Miller LG, Greenblatt DJ, Barnhill JG, Deutsch SI, Shader RI, Paul SM: Benzodiazepine receptor binding of triazolobenzodiazepines in vivo: increased receptor number with low-dose alprazolam. J Neurochem. 1987 Nov;49(5):1595-601. Pubmed

    10. Gamma-aminobutyric acid receptor subunit beta-3

    Kind: protein

    Organism: Human

    Pharmacological action: yes

    Actions: potentiator

    Components

    Name UniProt ID Details
    Gamma-aminobutyric acid receptor subunit beta-3 P28472 Details

    References:

    1. Braestrup C, Squires RF: Pharmacological characterization of benzodiazepine receptors in the brain. Eur J Pharmacol. 1978 Apr 1;48(3):263-70. Pubmed
    2. Miller LG, Greenblatt DJ, Barnhill JG, Deutsch SI, Shader RI, Paul SM: Benzodiazepine receptor binding of triazolobenzodiazepines in vivo: increased receptor number with low-dose alprazolam. J Neurochem. 1987 Nov;49(5):1595-601. Pubmed

    11. Gamma-aminobutyric acid receptor subunit delta

    Kind: protein

    Organism: Human

    Pharmacological action: yes

    Actions: potentiator

    Components

    Name UniProt ID Details
    Gamma-aminobutyric acid receptor subunit delta O14764 Details

    References:

    1. Braestrup C, Squires RF: Pharmacological characterization of benzodiazepine receptors in the brain. Eur J Pharmacol. 1978 Apr 1;48(3):263-70. Pubmed
    2. Miller LG, Greenblatt DJ, Barnhill JG, Deutsch SI, Shader RI, Paul SM: Benzodiazepine receptor binding of triazolobenzodiazepines in vivo: increased receptor number with low-dose alprazolam. J Neurochem. 1987 Nov;49(5):1595-601. Pubmed

    12. Gamma-aminobutyric acid receptor subunit epsilon

    Kind: protein

    Organism: Human

    Pharmacological action: yes

    Actions: potentiator

    Components

    Name UniProt ID Details
    Gamma-aminobutyric acid receptor subunit epsilon P78334 Details

    References:

    1. Braestrup C, Squires RF: Pharmacological characterization of benzodiazepine receptors in the brain. Eur J Pharmacol. 1978 Apr 1;48(3):263-70. Pubmed
    2. Miller LG, Greenblatt DJ, Barnhill JG, Deutsch SI, Shader RI, Paul SM: Benzodiazepine receptor binding of triazolobenzodiazepines in vivo: increased receptor number with low-dose alprazolam. J Neurochem. 1987 Nov;49(5):1595-601. Pubmed

    13. Gamma-aminobutyric acid receptor subunit pi

    Kind: protein

    Organism: Human

    Pharmacological action: yes

    Actions: potentiator

    Components

    Name UniProt ID Details
    Gamma-aminobutyric acid receptor subunit pi O00591 Details

    References:

    1. Braestrup C, Squires RF: Pharmacological characterization of benzodiazepine receptors in the brain. Eur J Pharmacol. 1978 Apr 1;48(3):263-70. Pubmed
    2. Miller LG, Greenblatt DJ, Barnhill JG, Deutsch SI, Shader RI, Paul SM: Benzodiazepine receptor binding of triazolobenzodiazepines in vivo: increased receptor number with low-dose alprazolam. J Neurochem. 1987 Nov;49(5):1595-601. Pubmed

    14. Gamma-aminobutyric acid receptor subunit rho-1

    Kind: protein

    Organism: Human

    Pharmacological action: yes

    Actions: potentiator

    Components

    Name UniProt ID Details
    Gamma-aminobutyric acid receptor subunit rho-1 P24046 Details

    References:

    1. Braestrup C, Squires RF: Pharmacological characterization of benzodiazepine receptors in the brain. Eur J Pharmacol. 1978 Apr 1;48(3):263-70. Pubmed
    2. Miller LG, Greenblatt DJ, Barnhill JG, Deutsch SI, Shader RI, Paul SM: Benzodiazepine receptor binding of triazolobenzodiazepines in vivo: increased receptor number with low-dose alprazolam. J Neurochem. 1987 Nov;49(5):1595-601. Pubmed

    15. Gamma-aminobutyric acid receptor subunit rho-2

    Kind: protein

    Organism: Human

    Pharmacological action: yes

    Actions: potentiator

    Components

    Name UniProt ID Details
    Gamma-aminobutyric acid receptor subunit rho-2 P28476 Details

    References:

    1. Braestrup C, Squires RF: Pharmacological characterization of benzodiazepine receptors in the brain. Eur J Pharmacol. 1978 Apr 1;48(3):263-70. Pubmed
    2. Miller LG, Greenblatt DJ, Barnhill JG, Deutsch SI, Shader RI, Paul SM: Benzodiazepine receptor binding of triazolobenzodiazepines in vivo: increased receptor number with low-dose alprazolam. J Neurochem. 1987 Nov;49(5):1595-601. Pubmed

    16. Gamma-aminobutyric acid receptor subunit rho-3

    Kind: protein

    Organism: Human

    Pharmacological action: yes

    Actions: potentiator

    Components

    Name UniProt ID Details
    Gamma-aminobutyric acid receptor subunit rho-3 A8MPY1 Details

    References:

    1. Braestrup C, Squires RF: Pharmacological characterization of benzodiazepine receptors in the brain. Eur J Pharmacol. 1978 Apr 1;48(3):263-70. Pubmed
    2. Miller LG, Greenblatt DJ, Barnhill JG, Deutsch SI, Shader RI, Paul SM: Benzodiazepine receptor binding of triazolobenzodiazepines in vivo: increased receptor number with low-dose alprazolam. J Neurochem. 1987 Nov;49(5):1595-601. Pubmed

    17. GABA-A receptor (anion channel)

    Kind: protein group

    Organism: Human

    Pharmacological action: yes

    Actions: positive allosteric modulator

    Components

    Name UniProt ID Details
    Gamma-aminobutyric acid receptor subunit alpha-1 P14867 Details
    Gamma-aminobutyric acid receptor subunit alpha-2 P47869 Details
    Gamma-aminobutyric acid receptor subunit alpha-3 P34903 Details
    Gamma-aminobutyric acid receptor subunit alpha-4 P48169 Details
    Gamma-aminobutyric acid receptor subunit alpha-5 P31644 Details
    Gamma-aminobutyric acid receptor subunit alpha-6 Q16445 Details
    Gamma-aminobutyric acid receptor subunit beta-1 P18505 Details
    Gamma-aminobutyric acid receptor subunit beta-2 P47870 Details
    Gamma-aminobutyric acid receptor subunit beta-3 P28472 Details
    Gamma-aminobutyric acid receptor subunit delta O14764 Details
    Gamma-aminobutyric acid receptor subunit epsilon P78334 Details
    Gamma-aminobutyric acid receptor subunit gamma-1 Q8N1C3 Details
    Gamma-aminobutyric acid receptor subunit gamma-2 P18507 Details
    Gamma-aminobutyric acid receptor subunit gamma-3 Q99928 Details
    Gamma-aminobutyric acid receptor subunit pi O00591 Details
    Gamma-aminobutyric acid receptor subunit theta Q9UN88 Details

    References:

    1. ChEMBL Compound Report Card (Accessed December 2013)

    1. Cytochrome P450 3A4

    Kind: protein

    Organism: Human

    Pharmacological action: unknown

    Actions: substrate

    Components

    Name UniProt ID Details
    Cytochrome P450 3A4 P08684 Details

    References:

    1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

    Comments
    Drug created on June 13, 2005 07:24 / Updated on September 16, 2013 17:13