You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.
Identification
NameFosamprenavir
Accession NumberDB01319
TypeSmall Molecule
GroupsApproved
DescriptionFosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease.
Structure
Thumb
Synonyms
Fosamprenavir
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Lexivatablet, film coated700 mg/1oralREMEDYREPACK INC.2013-05-09Not applicableUs
Lexivatablet, film coated700 mg/1oralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
Lexivatablet, film coated700 mg/1oralVii V Healthcare Company2010-10-04Not applicableUs
Lexivasuspension50 mg/mLoralVii V Healthcare Company2010-10-04Not applicableUs
Lexivatablet, film coated700 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
TelzirFilm-coated tablets700 mgOral useVii V Healthcare Uk Limited 2004-07-12Not applicableEu
TelzirOral suspension50 mg/mlOral useVii V Healthcare Uk Limited 2004-07-12Not applicableEu
Telzirtablet700 mgoralViiv Healthcare Ulc2004-12-22Not applicableCanada
Telzirsuspension50 mgoralViiv Healthcare Ulc2005-02-23Not applicableCanada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Fosamprenavir calcium
ThumbNot applicableDBSALT001228
Categories
UNIIWOU1621EEG
CAS number226700-79-4
WeightAverage: 585.607
Monoisotopic: 585.190986967
Chemical FormulaC25H36N3O9PS
InChI KeyInChIKey=MLBVMOWEQCZNCC-OEMFJLHTSA-N
InChI
InChI=1S/C25H36N3O9PS/c1-18(2)15-28(39(33,34)22-10-8-20(26)9-11-22)16-24(37-38(30,31)32)23(14-19-6-4-3-5-7-19)27-25(29)36-21-12-13-35-17-21/h3-11,18,21,23-24H,12-17,26H2,1-2H3,(H,27,29)(H2,30,31,32)/t21-,23-,24+/m0/s1
IUPAC Name
{[(2R,3S)-1-[N-(2-methylpropyl)4-aminobenzenesulfonamido]-3-({[(3S)-oxolan-3-yloxy]carbonyl}amino)-4-phenylbutan-2-yl]oxy}phosphonic acid
SMILES
CC(C)CN(C[C@@H](OP(O)(O)=O)[[email protected]](CC1=CC=CC=C1)NC(=O)O[[email protected]]1CCOC1)S(=O)(=O)C1=CC=C(N)C=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as aminobenzenesulfonamides. These are organic compounds containing a benzenesulfonamide moiety with an amine group attached to the benzene ring.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBenzenesulfonamides
Direct ParentAminobenzenesulfonamides
Alternative Parents
Substituents
  • Phenylbutylamine
  • Aminobenzenesulfonamide
  • Sulfonylaniline
  • Amphetamine or derivatives
  • Substituted aniline
  • Phosphoethanolamine
  • Monoalkyl phosphate
  • Aniline
  • Alkyl phosphate
  • Primary aromatic amine
  • Phosphoric acid ester
  • Organic phosphoric acid derivative
  • Organic phosphate
  • Aminosulfonyl compound
  • Sulfonyl
  • Sulfonic acid derivative
  • Sulfonamide
  • Oxolane
  • Oxacycle
  • Organoheterocyclic compound
  • Monocarboxylic acid or derivatives
  • Ether
  • Dialkyl ether
  • Hydrocarbon derivative
  • Primary amine
  • Organosulfur compound
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationIndicated in combination with other antiretroviral agents for the treatment of human immunodeficiency virus (HIV-1) infection, as well as postexposure prophylaxis of HIV infection in individuals who have had occupational or nonoccupational exposure to potentially infectious body fluids of a person known to be infected with HIV when that exposure represents a substantial risk for HIV transmission. The use of fosamprenavir is pending revision due to a potential association between the drug and myocardial infarction and dyslipidemia in HIV infected adults.
PharmacodynamicsFosamprenavir is a pro-drug of the protease inhibitor and antiretroviral drug amprenavir. It has little or no antiviral activity until it is hydrolyzed by cellular phosphatases into amprenavir, which is the active ingredient. That metabolization increases the duration that amprenavir is available, making fosamprenavir a slow-release version of amprenavir and thus reducing the number of pills required versus standard amprenavir.
Mechanism of actionFosamprenavir is a prodrug that is rapidly hydrolyzed to amprenavir by cellular phosphatases in the gut epithelium as it is absorbed. Amprenavir is an inhibitor of HIV-1 protease. During HIV replication, HIV protease cleaves viral polypeptide products of the Gag and Gag-Pol genes to form structural proteins of the virion core and essential viral enzymes. Amprenavir interferes with this process by binding to the active site of HIV-1 protease, thereby preventing the processing of viral Gag and Gag-Pol polyprotein precursors, resulting in the formation of immature non-infectious viral particles.
Related Articles
AbsorptionThe absolute oral bioavailability of amprenavir after administration of fosamprenavir in humans has not been established. After administration of a single 1,400 mg dose in the fasted state, fosamprenavir oral suspension (50 mg/mL) and fosamprenavir tablets (700 mg) provided similar amprenavir exposures (AUC), however, the Cmax of amprenavir after administration of the suspension formulation was 14.5 % higher compared with the tablet.
Volume of distributionNot Available
Protein bindingVery high (approximately 90%); primarily bound to alpha 1 -acid glycoprotein. Higher amounts of unbound amprenavir present as amprenavir serum concentrations increase.
Metabolism

In the gut epithelium during absorption, fosamprenavir is rapidly and almost completely hydrolyzed to amprenavir and inorganic phosphate prior to reaching the systemic circulation. Amprenavir is metabolized in the liver by the cytochrome P450 3A4 (CYP3A4) enzyme system.

Route of eliminationExcretion of unchanged amprenavir in urine and feces is minimal. The renal elimination of unchanged amprenavir represents approximately 1% of the administered dose; therefore, renal impairment is not expected to significantly impact the elimination of amprenavir. Amprenavir, the active metabolite of fosamprenavir, is metabolized in the liver by the cytochrome P450 enzyme system.
Half lifeThe plasma elimination half-life of amprenavir (the active metabolite) is approximately 7.7 hours.
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Human Immunodeficiency Virus
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.6363
Blood Brain Barrier+0.5379
Caco-2 permeable+0.6992
P-glycoprotein substrateSubstrate0.6482
P-glycoprotein inhibitor IInhibitor0.7374
P-glycoprotein inhibitor IINon-inhibitor0.7819
Renal organic cation transporterNon-inhibitor0.8671
CYP450 2C9 substrateSubstrate0.5877
CYP450 2D6 substrateSubstrate0.6061
CYP450 3A4 substrateSubstrate0.5805
CYP450 1A2 substrateNon-inhibitor0.7454
CYP450 2C9 inhibitorNon-inhibitor0.6627
CYP450 2D6 inhibitorNon-inhibitor0.8835
CYP450 2C19 inhibitorNon-inhibitor0.6591
CYP450 3A4 inhibitorNon-inhibitor0.6317
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.6969
Ames testNon AMES toxic0.598
CarcinogenicityNon-carcinogens0.78
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.5018 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9846
hERG inhibition (predictor II)Non-inhibitor0.8356
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Suspensionoral50 mg/mL
Tablet, film coatedoral700 mg/1
Film-coated tabletsOral use700 mg
Oral suspensionOral use50 mg/ml
Suspensionoral50 mg
Tabletoral700 mg
Prices
Unit descriptionCostUnit
Lexiva 700 mg tablet14.78USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2224738 No2002-08-272016-06-28Canada
CA2231700 No2005-08-092018-03-10Canada
US6436989 Yes1998-06-242018-06-24Us
US6514953 Yes2000-01-152020-01-15Us
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.685 mg/mLALOGPS
logP0.84ALOGPS
logP1.92ChemAxon
logS-2.9ALOGPS
pKa (Strongest Acidic)1.22ChemAxon
pKa (Strongest Basic)2.45ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count8ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area177.72 Å2ChemAxon
Rotatable Bond Count13ChemAxon
Refractivity144.95 m3·mol-1ChemAxon
Polarizability57.77 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

DrugSyn.org

US6559815
General References
  1. Smith KY, Weinberg WG, Dejesus E, Fischl MA, Liao Q, Ross LL, Pakes GE, Pappa KA, Lancaster CT: Fosamprenavir or atazanavir once daily boosted with ritonavir 100 mg, plus tenofovir/emtricitabine, for the initial treatment of HIV infection: 48-week results of ALERT. AIDS Res Ther. 2008 Mar 28;5:5. doi: 10.1186/1742-6405-5-5. [PubMed:18373851 ]
  2. Hoffman RM, Umeh OC, Garris C, Givens N, Currier JS: Evaluation of sex differences of fosamprenavir (with and without ritonavir) in HIV-infected men and women. HIV Clin Trials. 2007 Nov-Dec;8(6):371-80. [PubMed:18042502 ]
  3. Chapman TM, Plosker GL, Perry CM: Fosamprenavir: a review of its use in the management of antiretroviral therapy-naive patients with HIV infection. Drugs. 2004;64(18):2101-24. [PubMed:15341507 ]
  4. Furfine ES, Baker CT, Hale MR, Reynolds DJ, Salisbury JA, Searle AD, Studenberg SD, Todd D, Tung RD, Spaltenstein A: Preclinical pharmacology and pharmacokinetics of GW433908, a water-soluble prodrug of the human immunodeficiency virus protease inhibitor amprenavir. Antimicrob Agents Chemother. 2004 Mar;48(3):791-8. [PubMed:14982766 ]
  5. Sension M: Initial therapy for human immunodeficiency virus: broadening the options. HIV Clin Trials. 2004 Mar-Apr;5(2):99-111. [PubMed:15116286 ]
  6. Wood R, Arasteh K, Stellbrink HJ, Teofilo E, Raffi F, Pollard RB, Eron J, Yeo J, Millard J, Wire MB, Naderer OJ: Six-week randomized controlled trial to compare the tolerabilities, pharmacokinetics, and antiviral activities of GW433908 and amprenavir in human immunodeficiency virus type 1-infected patients. Antimicrob Agents Chemother. 2004 Jan;48(1):116-23. [PubMed:14693528 ]
  7. Falcoz C, Jenkins JM, Bye C, Hardman TC, Kenney KB, Studenberg S, Fuder H, Prince WT: Pharmacokinetics of GW433908, a prodrug of amprenavir, in healthy male volunteers. J Clin Pharmacol. 2002 Aug;42(8):887-98. [PubMed:12162471 ]
  8. Wire MB, Shelton MJ, Studenberg S: Fosamprenavir : clinical pharmacokinetics and drug interactions of the amprenavir prodrug. Clin Pharmacokinet. 2006;45(2):137-68. [PubMed:16485915 ]
External Links
ATC CodesJ05AE07
AHFS Codes
  • 08:18.08.08
PDB EntriesNot Available
FDA labelDownload (374 KB)
MSDSNot Available
Interactions
Drug Interactions
Drug
AbacavirThe serum concentration of Abacavir can be decreased when it is combined with Fosamprenavir.
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Fosamprenavir.
AcarboseThe therapeutic efficacy of Acarbose can be decreased when used in combination with Fosamprenavir.
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Fosamprenavir.
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Fosamprenavir.
AcetohexamideThe therapeutic efficacy of Acetohexamide can be decreased when used in combination with Fosamprenavir.
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Fosamprenavir.
AicarThe therapeutic efficacy of Aicar can be decreased when used in combination with Fosamprenavir.
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Fosamprenavir.
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Fosamprenavir.
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Fosamprenavir.
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Fosamprenavir.
AliskirenThe metabolism of Aliskiren can be decreased when combined with Fosamprenavir.
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Fosamprenavir.
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Fosamprenavir.
AlogliptinThe therapeutic efficacy of Alogliptin can be decreased when used in combination with Fosamprenavir.
AlosetronThe metabolism of Alosetron can be decreased when combined with Fosamprenavir.
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Fosamprenavir.
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Fosamprenavir.
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Fosamprenavir.
AmineptineThe serum concentration of Amineptine can be increased when it is combined with Fosamprenavir.
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Fosamprenavir.
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Fosamprenavir.
AmiodaroneThe serum concentration of Amiodarone can be increased when it is combined with Fosamprenavir.
AmiodaroneThe metabolism of Fosamprenavir can be decreased when combined with Amiodarone.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Fosamprenavir.
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Fosamprenavir.
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Fosamprenavir.
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Fosamprenavir.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Fosamprenavir.
ApremilastThe metabolism of Apremilast can be decreased when combined with Fosamprenavir.
AprepitantThe serum concentration of Fosamprenavir can be increased when it is combined with Aprepitant.
AprepitantThe metabolism of Aprepitant can be decreased when combined with Fosamprenavir.
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Fosamprenavir.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Fosamprenavir.
ArtemetherThe metabolism of Artemether can be decreased when combined with Fosamprenavir.
AsenapineThe serum concentration of Fosamprenavir can be decreased when it is combined with Asenapine.
AsenapineThe metabolism of Asenapine can be decreased when combined with Fosamprenavir.
AstemizoleThe metabolism of Astemizole can be decreased when combined with Fosamprenavir.
AtazanavirThe metabolism of Atazanavir can be decreased when combined with Fosamprenavir.
AtomoxetineThe metabolism of Fosamprenavir can be decreased when combined with Atomoxetine.
AtorvastatinThe metabolism of Atorvastatin can be decreased when combined with Fosamprenavir.
AvanafilThe metabolism of Avanafil can be decreased when combined with Fosamprenavir.
AxitinibThe metabolism of Axitinib can be decreased when combined with Fosamprenavir.
AzelastineThe metabolism of Azelastine can be decreased when combined with Fosamprenavir.
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Fosamprenavir.
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Fosamprenavir.
BedaquilineThe metabolism of Bedaquiline can be decreased when combined with Fosamprenavir.
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Fosamprenavir.
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Fosamprenavir.
BexaroteneThe serum concentration of Fosamprenavir can be decreased when it is combined with Bexarotene.
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Fosamprenavir.
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Fosamprenavir.
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Fosamprenavir.
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Fosamprenavir.
BoceprevirThe serum concentration of Fosamprenavir can be decreased when it is combined with Boceprevir.
BoceprevirThe metabolism of Boceprevir can be decreased when combined with Fosamprenavir.
BortezomibThe metabolism of Fosamprenavir can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Fosamprenavir can be decreased when it is combined with Bosentan.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Fosamprenavir.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Fosamprenavir.
Brentuximab vedotinThe metabolism of Brentuximab vedotin can be decreased when combined with Fosamprenavir.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Fosamprenavir.
BrinzolamideThe metabolism of Brinzolamide can be decreased when combined with Fosamprenavir.
BromazepamThe metabolism of Bromazepam can be decreased when combined with Fosamprenavir.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Fosamprenavir.
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Fosamprenavir.
BudesonideThe metabolism of Budesonide can be decreased when combined with Fosamprenavir.
BuforminThe therapeutic efficacy of Buformin can be decreased when used in combination with Fosamprenavir.
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Fosamprenavir.
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Fosamprenavir.
BupropionThe metabolism of Bupropion can be decreased when combined with Fosamprenavir.
BuspironeThe metabolism of Buspirone can be decreased when combined with Fosamprenavir.
BusulfanThe metabolism of Busulfan can be decreased when combined with Fosamprenavir.
CabazitaxelThe metabolism of Cabazitaxel can be decreased when combined with Fosamprenavir.
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Fosamprenavir.
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Fosamprenavir.
CaffeineThe metabolism of Caffeine can be decreased when combined with Fosamprenavir.
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Fosamprenavir.
CanagliflozinThe therapeutic efficacy of Canagliflozin can be decreased when used in combination with Fosamprenavir.
CarbamazepineThe metabolism of Fosamprenavir can be increased when combined with Carbamazepine.
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Fosamprenavir.
CariprazineThe metabolism of Cariprazine can be decreased when combined with Fosamprenavir.
CarvedilolThe metabolism of Carvedilol can be decreased when combined with Fosamprenavir.
CastanospermineThe therapeutic efficacy of Castanospermine can be decreased when used in combination with Fosamprenavir.
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Fosamprenavir.
CeliprololThe metabolism of Celiprolol can be decreased when combined with Fosamprenavir.
CephalexinThe metabolism of Cephalexin can be decreased when combined with Fosamprenavir.
CeritinibThe serum concentration of Fosamprenavir can be increased when it is combined with Ceritinib.
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Fosamprenavir.
CevimelineThe metabolism of Cevimeline can be decreased when combined with Fosamprenavir.
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Fosamprenavir.
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Fosamprenavir.
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Fosamprenavir.
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Fosamprenavir.
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Fosamprenavir.
ChlorpropamideThe therapeutic efficacy of Chlorpropamide can be decreased when used in combination with Fosamprenavir.
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Fosamprenavir.
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Fosamprenavir.
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Fosamprenavir.
CiglitazoneThe therapeutic efficacy of Ciglitazone can be decreased when used in combination with Fosamprenavir.
CilostazolThe metabolism of Cilostazol can be decreased when combined with Fosamprenavir.
CimetidineThe serum concentration of Fosamprenavir can be decreased when it is combined with Cimetidine.
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Fosamprenavir.
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Fosamprenavir.
CitalopramThe metabolism of Citalopram can be decreased when combined with Fosamprenavir.
ClarithromycinThe metabolism of Clarithromycin can be decreased when combined with Fosamprenavir.
ClemastineThe metabolism of Fosamprenavir can be decreased when combined with Clemastine.
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Fosamprenavir.
ClobazamThe metabolism of Clobazam can be decreased when combined with Fosamprenavir.
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Fosamprenavir.
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Fosamprenavir.
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Fosamprenavir.
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Fosamprenavir.
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Fosamprenavir.
ClonidineThe metabolism of Clonidine can be decreased when combined with Fosamprenavir.
ClopidogrelThe metabolism of Clopidogrel can be decreased when combined with Fosamprenavir.
ClorazepateThe serum concentration of Clorazepate can be increased when it is combined with Fosamprenavir.
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Fosamprenavir.
ClotrimazoleThe metabolism of Fosamprenavir can be decreased when combined with Clotrimazole.
ClozapineThe metabolism of Clozapine can be decreased when combined with Fosamprenavir.
CobicistatThe metabolism of Fosamprenavir can be decreased when combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Fosamprenavir.
CocaineThe metabolism of Cocaine can be decreased when combined with Fosamprenavir.
CodeineThe metabolism of Codeine can be decreased when combined with Fosamprenavir.
ColchicineThe metabolism of Colchicine can be decreased when combined with Fosamprenavir.
ConivaptanThe serum concentration of Fosamprenavir can be increased when it is combined with Conivaptan.
ConivaptanThe metabolism of Conivaptan can be decreased when combined with Fosamprenavir.
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be decreased when combined with Fosamprenavir.
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Fosamprenavir.
CrizotinibThe metabolism of Crizotinib can be decreased when combined with Fosamprenavir.
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Fosamprenavir.
CyclophosphamideThe risk or severity of adverse effects can be increased when Fosamprenavir is combined with Cyclophosphamide.
CyclosporineThe metabolism of Fosamprenavir can be decreased when combined with Cyclosporine.
CytarabineThe metabolism of Cytarabine can be decreased when combined with Fosamprenavir.
DabrafenibThe serum concentration of Fosamprenavir can be decreased when it is combined with Dabrafenib.
DabrafenibThe metabolism of Dabrafenib can be decreased when combined with Fosamprenavir.
DaclatasvirThe metabolism of Daclatasvir can be decreased when combined with Fosamprenavir.
DantroleneThe metabolism of Dantrolene can be decreased when combined with Fosamprenavir.
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Fosamprenavir.
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Fosamprenavir.
DapsoneThe metabolism of Dapsone can be decreased when combined with Fosamprenavir.
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Fosamprenavir.
DarunavirThe metabolism of Darunavir can be decreased when combined with Fosamprenavir.
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Fosamprenavir.
DasatinibThe serum concentration of Fosamprenavir can be increased when it is combined with Dasatinib.
DasatinibThe metabolism of Dasatinib can be decreased when combined with Fosamprenavir.
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Fosamprenavir.
DeferasiroxThe serum concentration of Fosamprenavir can be decreased when it is combined with Deferasirox.
DehydroepiandrosteroneThe metabolism of Dehydroepiandrosterone can be decreased when combined with Fosamprenavir.
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Fosamprenavir.
DelavirdineThe metabolism of Fosamprenavir can be decreased when combined with Delavirdine.
DesipramineThe serum concentration of Desipramine can be increased when it is combined with Fosamprenavir.
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Fosamprenavir.
DexamethasoneThe serum concentration of Fosamprenavir can be decreased when it is combined with Dexamethasone.
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Fosamprenavir.
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Fosamprenavir.
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Fosamprenavir.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Fosamprenavir.
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Fosamprenavir.
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Fosamprenavir.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Fosamprenavir.
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Fosamprenavir.
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Fosamprenavir.
DihydroergotamineThe metabolism of Fosamprenavir can be decreased when combined with Dihydroergotamine.
DiltiazemThe metabolism of Fosamprenavir can be decreased when combined with Diltiazem.
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Fosamprenavir.
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Fosamprenavir.
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Fosamprenavir.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Fosamprenavir.
DolasetronThe metabolism of Dolasetron can be decreased when combined with Fosamprenavir.
DolutegravirThe serum concentration of Dolutegravir can be decreased when it is combined with Fosamprenavir.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Fosamprenavir.
DonepezilThe metabolism of Donepezil can be decreased when combined with Fosamprenavir.
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Fosamprenavir.
DosulepinThe serum concentration of Dosulepin can be increased when it is combined with Fosamprenavir.
DoxepinThe serum concentration of Fosamprenavir can be decreased when it is combined with Doxepin.
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Fosamprenavir.
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Fosamprenavir.
DoxycyclineThe metabolism of Fosamprenavir can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Fosamprenavir.
DronedaroneThe metabolism of Dronedarone can be decreased when combined with Fosamprenavir.
DulaglutideThe therapeutic efficacy of Dulaglutide can be decreased when used in combination with Fosamprenavir.
DutasterideThe metabolism of Dutasteride can be decreased when combined with Fosamprenavir.
EfavirenzThe serum concentration of Fosamprenavir can be decreased when it is combined with Efavirenz.
EfavirenzThe metabolism of Efavirenz can be decreased when combined with Fosamprenavir.
EletriptanThe metabolism of Eletriptan can be decreased when combined with Fosamprenavir.
EliglustatThe metabolism of Eliglustat can be decreased when combined with Fosamprenavir.
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Fosamprenavir.
EmpagliflozinThe therapeutic efficacy of Empagliflozin can be decreased when used in combination with Fosamprenavir.
EnalaprilThe metabolism of Enalapril can be decreased when combined with Fosamprenavir.
EnfuvirtideThe serum concentration of Enfuvirtide can be increased when it is combined with Fosamprenavir.
EnzalutamideThe serum concentration of Fosamprenavir can be decreased when it is combined with Enzalutamide.
EnzalutamideThe metabolism of Enzalutamide can be decreased when combined with Fosamprenavir.
EpinastineThe serum concentration of Fosamprenavir can be decreased when it is combined with Epinastine.
EpinastineThe metabolism of Epinastine can be decreased when combined with Fosamprenavir.
EplerenoneThe metabolism of Eplerenone can be decreased when combined with Fosamprenavir.
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Fosamprenavir.
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Fosamprenavir.
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Fosamprenavir.
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Fosamprenavir.
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Fosamprenavir.
ErythromycinThe metabolism of Fosamprenavir can be decreased when combined with Erythromycin.
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Fosamprenavir.
Eslicarbazepine acetateThe serum concentration of Fosamprenavir can be decreased when it is combined with Eslicarbazepine acetate.
EsmirtazapineThe serum concentration of Esmirtazapine can be increased when it is combined with Fosamprenavir.
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Fosamprenavir.
EstazolamThe metabolism of Estazolam can be decreased when combined with Fosamprenavir.
EstradiolThe metabolism of Estradiol can be decreased when combined with Fosamprenavir.
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Fosamprenavir.
EstramustineThe metabolism of Estramustine can be decreased when combined with Fosamprenavir.
EstroneThe metabolism of Estrone can be decreased when combined with Fosamprenavir.
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Fosamprenavir.
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Fosamprenavir.
EthanolThe metabolism of Ethanol can be decreased when combined with Fosamprenavir.
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Fosamprenavir.
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Fosamprenavir.
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Fosamprenavir.
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Fosamprenavir.
EtoposideThe metabolism of Etoposide can be decreased when combined with Fosamprenavir.
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Fosamprenavir.
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Fosamprenavir.
EtravirineThe serum concentration of the active metabolites of Fosamprenavir can be increased when Fosamprenavir is used in combination with Etravirine.
EverolimusThe metabolism of Everolimus can be decreased when combined with Fosamprenavir.
ExemestaneThe metabolism of Exemestane can be decreased when combined with Fosamprenavir.
ExenatideThe therapeutic efficacy of Exenatide can be decreased when used in combination with Fosamprenavir.
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Fosamprenavir.
FamotidineThe serum concentration of Fosamprenavir can be decreased when it is combined with Famotidine.
FelbamateThe metabolism of Felbamate can be decreased when combined with Fosamprenavir.
FelodipineThe metabolism of Felodipine can be decreased when combined with Fosamprenavir.
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Fosamprenavir.
FentanylThe metabolism of Fentanyl can be decreased when combined with Fosamprenavir.
FesoterodineThe metabolism of Fesoterodine can be decreased when combined with Fosamprenavir.
FinasterideThe metabolism of Finasteride can be decreased when combined with Fosamprenavir.
FingolimodThe metabolism of Fingolimod can be decreased when combined with Fosamprenavir.
FlecainideThe serum concentration of Flecainide can be increased when it is combined with Fosamprenavir.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Fosamprenavir.
FluconazoleThe metabolism of Fosamprenavir can be decreased when combined with Fluconazole.
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Fosamprenavir.
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Fosamprenavir.
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Fosamprenavir.
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Fosamprenavir.
FlurazepamThe serum concentration of Flurazepam can be increased when it is combined with Fosamprenavir.
FlutamideThe metabolism of Flutamide can be decreased when combined with Fosamprenavir.
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Fosamprenavir.
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be decreased when combined with Fosamprenavir.
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Fosamprenavir.
FluvoxamineThe metabolism of Fosamprenavir can be decreased when combined with Fluvoxamine.
FosaprepitantThe serum concentration of Fosamprenavir can be increased when it is combined with Fosaprepitant.
FosphenytoinThe serum concentration of Fosamprenavir can be increased when it is combined with Fosphenytoin.
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Fosamprenavir.
Fusidic AcidThe serum concentration of Fosamprenavir can be increased when it is combined with Fusidic Acid.
GalantamineThe metabolism of Galantamine can be decreased when combined with Fosamprenavir.
GarlicThe serum concentration of Fosamprenavir can be decreased when it is combined with Garlic.
GefitinibThe metabolism of Gefitinib can be decreased when combined with Fosamprenavir.
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Fosamprenavir.
GlibornurideThe therapeutic efficacy of Glibornuride can be decreased when used in combination with Fosamprenavir.
GliclazideThe therapeutic efficacy of Gliclazide can be decreased when used in combination with Fosamprenavir.
GlimepirideThe therapeutic efficacy of Glimepiride can be decreased when used in combination with Fosamprenavir.
GlipizideThe therapeutic efficacy of Glipizide can be decreased when used in combination with Fosamprenavir.
GliquidoneThe therapeutic efficacy of Gliquidone can be decreased when used in combination with Fosamprenavir.
GlyburideThe therapeutic efficacy of Glyburide can be decreased when used in combination with Fosamprenavir.
GranisetronThe metabolism of Granisetron can be decreased when combined with Fosamprenavir.
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Fosamprenavir.
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Fosamprenavir.
HalofantrineThe metabolism of Halofantrine can be decreased when combined with Fosamprenavir.
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Fosamprenavir.
HalothaneThe metabolism of Halothane can be decreased when combined with Fosamprenavir.
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Fosamprenavir.
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Fosamprenavir.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Fosamprenavir.
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Fosamprenavir.
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Fosamprenavir.
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Fosamprenavir.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Fosamprenavir.
IdelalisibThe serum concentration of Fosamprenavir can be increased when it is combined with Idelalisib.
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Fosamprenavir resulting in a loss in efficacy.
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Fosamprenavir.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Fosamprenavir.
ImatinibThe metabolism of Fosamprenavir can be decreased when combined with Imatinib.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Fosamprenavir.
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Fosamprenavir.
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Fosamprenavir.
IndapamideThe metabolism of Indapamide can be decreased when combined with Fosamprenavir.
IndinavirThe metabolism of Indinavir can be decreased when combined with Fosamprenavir.
Insulin AspartThe therapeutic efficacy of Insulin Aspart can be decreased when used in combination with Fosamprenavir.
Insulin DetemirThe therapeutic efficacy of Insulin Detemir can be decreased when used in combination with Fosamprenavir.
Insulin GlargineThe therapeutic efficacy of Insulin Glargine can be decreased when used in combination with Fosamprenavir.
Insulin GlulisineThe therapeutic efficacy of Insulin Glulisine can be decreased when used in combination with Fosamprenavir.
Insulin LisproThe therapeutic efficacy of Insulin Lispro can be decreased when used in combination with Fosamprenavir.
Insulin PorkThe therapeutic efficacy of Insulin Pork can be decreased when used in combination with Fosamprenavir.
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Fosamprenavir.
IrinotecanThe metabolism of Irinotecan can be decreased when combined with Fosamprenavir.
IsavuconazoniumThe metabolism of Fosamprenavir can be decreased when combined with Isavuconazonium.
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Fosamprenavir.
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Fosamprenavir.
IsradipineThe metabolism of Fosamprenavir can be decreased when combined with Isradipine.
ItraconazoleThe serum concentration of the active metabolites of Fosamprenavir can be increased when Fosamprenavir is used in combination with Itraconazole.
ItraconazoleThe metabolism of Itraconazole can be decreased when combined with Fosamprenavir.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Fosamprenavir.
IvacaftorThe serum concentration of Fosamprenavir can be increased when it is combined with Ivacaftor.
IvacaftorThe metabolism of Ivacaftor can be decreased when combined with Fosamprenavir.
IvermectinThe metabolism of Ivermectin can be decreased when combined with Fosamprenavir.
IxabepiloneThe metabolism of Ixabepilone can be decreased when combined with Fosamprenavir.
IxazomibThe metabolism of Ixazomib can be decreased when combined with Fosamprenavir.
KetamineThe metabolism of Ketamine can be decreased when combined with Fosamprenavir.
KetazolamThe metabolism of Ketazolam can be decreased when combined with Fosamprenavir.
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Fosamprenavir.
KetoconazoleThe serum concentration of the active metabolites of Fosamprenavir can be increased when Fosamprenavir is used in combination with Ketoconazole.
KetoconazoleThe metabolism of Ketoconazole can be decreased when combined with Fosamprenavir.
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Fosamprenavir.
LapatinibThe metabolism of Lapatinib can be decreased when combined with Fosamprenavir.
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Fosamprenavir.
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Fosamprenavir.
LercanidipineThe metabolism of Lercanidipine can be decreased when combined with Fosamprenavir.
LetrozoleThe metabolism of Letrozole can be decreased when combined with Fosamprenavir.
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Fosamprenavir.
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Fosamprenavir.
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Fosamprenavir.
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Fosamprenavir.
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Fosamprenavir.
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Fosamprenavir.
LidocaineThe metabolism of Lidocaine can be decreased when combined with Fosamprenavir.
LinagliptinThe therapeutic efficacy of Linagliptin can be decreased when used in combination with Fosamprenavir.
LiraglutideThe therapeutic efficacy of Liraglutide can be decreased when used in combination with Fosamprenavir.
LisurideThe metabolism of Lisuride can be decreased when combined with Fosamprenavir.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Fosamprenavir.
LoperamideThe metabolism of Loperamide can be decreased when combined with Fosamprenavir.
LopinavirThe serum concentration of Lopinavir can be decreased when it is combined with Fosamprenavir.
LopinavirThe metabolism of Fosamprenavir can be decreased when combined with Lopinavir.
LoratadineThe metabolism of Loratadine can be decreased when combined with Fosamprenavir.
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Fosamprenavir.
LosartanThe metabolism of Losartan can be decreased when combined with Fosamprenavir.
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Fosamprenavir.
LovastatinThe metabolism of Fosamprenavir can be decreased when combined with Lovastatin.
LuliconazoleThe serum concentration of Fosamprenavir can be increased when it is combined with Luliconazole.
LumefantrineThe metabolism of Lumefantrine can be decreased when combined with Fosamprenavir.
LurasidoneThe metabolism of Lurasidone can be decreased when combined with Fosamprenavir.
MacitentanThe metabolism of Macitentan can be decreased when combined with Fosamprenavir.
MaravirocThe metabolism of Maraviroc can be decreased when combined with Fosamprenavir.
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Fosamprenavir.
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be decreased when combined with Fosamprenavir.
MefloquineThe metabolism of Mefloquine can be decreased when combined with Fosamprenavir.
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Fosamprenavir.
MetforminThe therapeutic efficacy of Metformin can be decreased when used in combination with Fosamprenavir.
MethadoneThe serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with Methadone resulting in a loss in efficacy.
MethadoneThe metabolism of Methadone can be decreased when combined with Fosamprenavir.
MethanthelineThe serum concentration of Fosamprenavir can be decreased when it is combined with Methantheline.
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Fosamprenavir.
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Fosamprenavir.
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Fosamprenavir.
MethylprednisoloneThe metabolism of Methylprednisolone can be decreased when combined with Fosamprenavir.
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Fosamprenavir.
MetiamideThe serum concentration of Fosamprenavir can be decreased when it is combined with Metiamide.
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Fosamprenavir.
MexiletineThe metabolism of Mexiletine can be decreased when combined with Fosamprenavir.
MianserinThe metabolism of Mianserin can be decreased when combined with Fosamprenavir.
MibefradilThe metabolism of Mibefradil can be decreased when combined with Fosamprenavir.
MiconazoleThe metabolism of Miconazole can be decreased when combined with Fosamprenavir.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Fosamprenavir.
MifepristoneThe metabolism of Fosamprenavir can be decreased when combined with Mifepristone.
MiglitolThe therapeutic efficacy of Miglitol can be decreased when used in combination with Fosamprenavir.
MiglustatThe therapeutic efficacy of Miglustat can be decreased when used in combination with Fosamprenavir.
MirabegronThe metabolism of Mirabegron can be decreased when combined with Fosamprenavir.
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Fosamprenavir.
MitiglinideThe therapeutic efficacy of Mitiglinide can be decreased when used in combination with Fosamprenavir.
MitotaneThe serum concentration of Fosamprenavir can be decreased when it is combined with Mitotane.
ModafinilThe serum concentration of Fosamprenavir can be decreased when it is combined with Modafinil.
ModafinilThe metabolism of Modafinil can be decreased when combined with Fosamprenavir.
MontelukastThe metabolism of Montelukast can be decreased when combined with Fosamprenavir.
MorphineThe metabolism of Morphine can be decreased when combined with Fosamprenavir.
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Fosamprenavir.
NafcillinThe serum concentration of Fosamprenavir can be decreased when it is combined with Nafcillin.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Fosamprenavir.
NaloxoneThe metabolism of Naloxone can be decreased when combined with Fosamprenavir.
NateglinideThe therapeutic efficacy of Nateglinide can be decreased when used in combination with Fosamprenavir.
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Fosamprenavir.
NelfinavirThe metabolism of Nelfinavir can be decreased when combined with Fosamprenavir.
NetupitantThe serum concentration of Fosamprenavir can be increased when it is combined with Netupitant.
NevirapineThe metabolism of Fosamprenavir can be decreased when combined with Nevirapine.
NicardipineThe metabolism of Nicardipine can be decreased when combined with Fosamprenavir.
NicotineThe metabolism of Nicotine can be decreased when combined with Fosamprenavir.
NifedipineThe metabolism of Nifedipine can be decreased when combined with Fosamprenavir.
NilotinibThe metabolism of Nilotinib can be decreased when combined with Fosamprenavir.
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Fosamprenavir.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Fosamprenavir.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Fosamprenavir.
NisoldipineThe metabolism of Nisoldipine can be decreased when combined with Fosamprenavir.
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Fosamprenavir.
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Fosamprenavir.
NizatidineThe serum concentration of Fosamprenavir can be decreased when it is combined with Nizatidine.
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Fosamprenavir.
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Fosamprenavir.
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Fosamprenavir.
OlanzapineThe serum concentration of Fosamprenavir can be decreased when it is combined with Olanzapine.
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Fosamprenavir.
OlaparibThe metabolism of Fosamprenavir can be decreased when combined with Olaparib.
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Fosamprenavir.
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Fosamprenavir.
OndansetronThe metabolism of Ondansetron can be decreased when combined with Fosamprenavir.
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Fosamprenavir.
OsimertinibThe serum concentration of Fosamprenavir can be increased when it is combined with Osimertinib.
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Fosamprenavir.
OxazepamThe metabolism of Oxazepam can be decreased when combined with Fosamprenavir.
OxybutyninThe metabolism of Oxybutynin can be decreased when combined with Fosamprenavir.
OxycodoneThe metabolism of Oxycodone can be decreased when combined with Fosamprenavir.
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Fosamprenavir.
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Fosamprenavir.
PalbociclibThe serum concentration of Fosamprenavir can be increased when it is combined with Palbociclib.
PalbociclibThe metabolism of Palbociclib can be decreased when combined with Fosamprenavir.
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Fosamprenavir.
PanobinostatThe metabolism of Panobinostat can be decreased when combined with Fosamprenavir.
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Fosamprenavir.
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Fosamprenavir.
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Fosamprenavir.
ParecoxibThe metabolism of Parecoxib can be decreased when combined with Fosamprenavir.
ParicalcitolThe metabolism of Paricalcitol can be decreased when combined with Fosamprenavir.
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Fosamprenavir.
ParoxetineThe serum concentration of Paroxetine can be decreased when it is combined with Fosamprenavir.
PazopanibThe metabolism of Pazopanib can be decreased when combined with Fosamprenavir.
PentamidineThe metabolism of Pentamidine can be decreased when combined with Fosamprenavir.
PentobarbitalThe metabolism of Fosamprenavir can be increased when combined with Pentobarbital.
PerampanelThe metabolism of Perampanel can be decreased when combined with Fosamprenavir.
PergolideThe metabolism of Pergolide can be decreased when combined with Fosamprenavir.
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Fosamprenavir.
PermethrinThe metabolism of Permethrin can be decreased when combined with Fosamprenavir.
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Fosamprenavir.
PethidineThe metabolism of Pethidine can be decreased when combined with Fosamprenavir.
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Fosamprenavir.
PhenforminThe therapeutic efficacy of Phenformin can be decreased when used in combination with Fosamprenavir.
PhenobarbitalThe metabolism of Fosamprenavir can be increased when combined with Phenobarbital.
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Fosamprenavir.
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Fosamprenavir.
PhenytoinThe serum concentration of Phenytoin can be decreased when it is combined with Fosamprenavir.
PhenytoinThe metabolism of Fosamprenavir can be increased when combined with Phenytoin.
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Fosamprenavir.
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Fosamprenavir.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Fosamprenavir.
PinacidilThe metabolism of Pinacidil can be decreased when combined with Fosamprenavir.
PioglitazoneThe therapeutic efficacy of Pioglitazone can be decreased when used in combination with Fosamprenavir.
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Fosamprenavir.
PodofiloxThe metabolism of Podofilox can be decreased when combined with Fosamprenavir.
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Fosamprenavir.
PonatinibThe metabolism of Ponatinib can be decreased when combined with Fosamprenavir.
PosaconazoleThe serum concentration of the active metabolites of Fosamprenavir can be increased when Fosamprenavir is used in combination with Posaconazole.
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Fosamprenavir.
PramlintideThe therapeutic efficacy of Pramlintide can be decreased when used in combination with Fosamprenavir.
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Fosamprenavir.
PravastatinThe metabolism of Pravastatin can be decreased when combined with Fosamprenavir.
PrazepamThe metabolism of Prazepam can be decreased when combined with Fosamprenavir.
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Fosamprenavir.
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Fosamprenavir.
PrednisoneThe metabolism of Prednisone can be decreased when combined with Fosamprenavir.
PrimaquineThe metabolism of Primaquine can be decreased when combined with Fosamprenavir.
PrimidoneThe metabolism of Fosamprenavir can be increased when combined with Primidone.
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Fosamprenavir.
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Fosamprenavir.
ProguanilThe metabolism of Proguanil can be decreased when combined with Fosamprenavir.
PromazineThe metabolism of Promazine can be decreased when combined with Fosamprenavir.
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Fosamprenavir.
PropofolThe metabolism of Propofol can be decreased when combined with Fosamprenavir.
PropranololThe metabolism of Propranolol can be decreased when combined with Fosamprenavir.
ProtriptylineThe serum concentration of Protriptyline can be increased when it is combined with Fosamprenavir.
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Fosamprenavir.
QuazepamThe metabolism of Quazepam can be decreased when combined with Fosamprenavir.
QuetiapineThe metabolism of Quetiapine can be decreased when combined with Fosamprenavir.
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Fosamprenavir.
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Fosamprenavir.
QuinineThe metabolism of Quinine can be decreased when combined with Fosamprenavir.
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Fosamprenavir.
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Fosamprenavir.
RaltegravirThe serum concentration of Raltegravir can be decreased when it is combined with Fosamprenavir.
RamelteonThe metabolism of Ramelteon can be decreased when combined with Fosamprenavir.
RanitidineThe serum concentration of Fosamprenavir can be decreased when it is combined with Ranitidine.
RanolazineThe metabolism of Fosamprenavir can be decreased when combined with Ranolazine.
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Fosamprenavir.
RegorafenibThe metabolism of Regorafenib can be decreased when combined with Fosamprenavir.
RepaglinideThe therapeutic efficacy of Repaglinide can be decreased when used in combination with Fosamprenavir.
RetapamulinThe metabolism of Retapamulin can be decreased when combined with Fosamprenavir.
RifabutinThe metabolism of Fosamprenavir can be increased when combined with Rifabutin.
RifampicinThe serum concentration of Fosamprenavir can be decreased when it is combined with Rifampicin.
RifampicinThe metabolism of Rifampicin can be decreased when combined with Fosamprenavir.
RifapentineThe metabolism of Fosamprenavir can be increased when combined with Rifapentine.
RilpivirineThe metabolism of Rilpivirine can be decreased when combined with Fosamprenavir.
RimonabantThe metabolism of Rimonabant can be decreased when combined with Fosamprenavir.
RiociguatThe metabolism of Riociguat can be decreased when combined with Fosamprenavir.
RisperidoneThe metabolism of Risperidone can be decreased when combined with Fosamprenavir.
RitonavirThe metabolism of Ritonavir can be decreased when combined with Fosamprenavir.
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Fosamprenavir.
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Fosamprenavir.
RolapitantThe metabolism of Rolapitant can be decreased when combined with Fosamprenavir.
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Fosamprenavir.
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Fosamprenavir.
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Fosamprenavir.
RosiglitazoneThe therapeutic efficacy of Rosiglitazone can be decreased when used in combination with Fosamprenavir.
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Fosamprenavir.
RotigotineThe metabolism of Rotigotine can be decreased when combined with Fosamprenavir.
Roxatidine acetateThe serum concentration of Fosamprenavir can be decreased when it is combined with Roxatidine acetate.
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Fosamprenavir.
RuxolitinibThe metabolism of Ruxolitinib can be decreased when combined with Fosamprenavir.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Fosamprenavir.
SaquinavirThe metabolism of Saquinavir can be decreased when combined with Fosamprenavir.
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Fosamprenavir.
SelegilineThe metabolism of Selegiline can be decreased when combined with Fosamprenavir.
SelexipagThe metabolism of Selexipag can be decreased when combined with Fosamprenavir.
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Fosamprenavir.
SertindoleThe metabolism of Sertindole can be decreased when combined with Fosamprenavir.
SertralineThe metabolism of Sertraline can be decreased when combined with Fosamprenavir.
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Fosamprenavir.
SibutramineThe metabolism of Sibutramine can be decreased when combined with Fosamprenavir.
SildenafilThe metabolism of Fosamprenavir can be decreased when combined with Sildenafil.
SilodosinThe metabolism of Silodosin can be decreased when combined with Fosamprenavir.
SiltuximabThe serum concentration of Fosamprenavir can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Fosamprenavir can be increased when it is combined with Simeprevir.
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Fosamprenavir.
SirolimusThe metabolism of Sirolimus can be decreased when combined with Fosamprenavir.
SitagliptinThe therapeutic efficacy of Sitagliptin can be decreased when used in combination with Fosamprenavir.
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Fosamprenavir.
SonidegibThe metabolism of Sonidegib can be decreased when combined with Fosamprenavir.
SorafenibThe metabolism of Sorafenib can be decreased when combined with Fosamprenavir.
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Fosamprenavir.
St. John's WortThe metabolism of Fosamprenavir can be increased when combined with St. John's Wort.
StiripentolThe serum concentration of Fosamprenavir can be increased when it is combined with Stiripentol.
SufentanilThe metabolism of Sufentanil can be decreased when combined with Fosamprenavir.
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Fosamprenavir.
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Fosamprenavir.
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Fosamprenavir.
SulfisoxazoleThe metabolism of Fosamprenavir can be decreased when combined with Sulfisoxazole.
SulodexideThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Fosamprenavir.
SunitinibThe metabolism of Sunitinib can be decreased when combined with Fosamprenavir.
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Fosamprenavir.
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Fosamprenavir.
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Fosamprenavir.
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Fosamprenavir.
TadalafilThe metabolism of Tadalafil can be decreased when combined with Fosamprenavir.
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Fosamprenavir.
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Fosamprenavir.
TasosartanThe metabolism of Tasosartan can be decreased when combined with Fosamprenavir.
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Fosamprenavir.
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Fosamprenavir.
TelaprevirThe metabolism of Fosamprenavir can be decreased when combined with Telaprevir.
TelithromycinThe metabolism of Telithromycin can be decreased when combined with Fosamprenavir.
TemazepamThe metabolism of Temazepam can be decreased when combined with Fosamprenavir.
TemsirolimusThe metabolism of Temsirolimus can be decreased when combined with Fosamprenavir.
TeniposideThe metabolism of Teniposide can be decreased when combined with Fosamprenavir.
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Fosamprenavir.
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Fosamprenavir.
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Fosamprenavir.
TestosteroneThe metabolism of Testosterone can be decreased when combined with Fosamprenavir.
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Fosamprenavir.
TheophyllineThe metabolism of Theophylline can be decreased when combined with Fosamprenavir.
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Fosamprenavir.
TiagabineThe metabolism of Tiagabine can be decreased when combined with Fosamprenavir.
TianeptineThe serum concentration of Tianeptine can be increased when it is combined with Fosamprenavir.
TicagrelorThe metabolism of Ticagrelor can be decreased when combined with Fosamprenavir.
TiclopidineThe metabolism of Fosamprenavir can be decreased when combined with Ticlopidine.
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Fosamprenavir.
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Fosamprenavir.
TipranavirThe serum concentration of Fosamprenavir can be decreased when it is combined with Tipranavir.
TipranavirThe metabolism of Tipranavir can be decreased when combined with Fosamprenavir.
TocilizumabThe serum concentration of Fosamprenavir can be decreased when it is combined with Tocilizumab.
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Fosamprenavir.
TolazamideThe therapeutic efficacy of Tolazamide can be decreased when used in combination with Fosamprenavir.
TolbutamideThe therapeutic efficacy of Tolbutamide can be decreased when used in combination with Fosamprenavir.
TolterodineThe metabolism of Tolterodine can be decreased when combined with Fosamprenavir.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Fosamprenavir.
ToremifeneThe metabolism of Toremifene can be decreased when combined with Fosamprenavir.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Fosamprenavir.
TramadolThe metabolism of Tramadol can be decreased when combined with Fosamprenavir.
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be decreased when combined with Fosamprenavir.
TrazodoneThe metabolism of Trazodone can be decreased when combined with Fosamprenavir.
TretinoinThe metabolism of Tretinoin can be decreased when combined with Fosamprenavir.
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Fosamprenavir.
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Fosamprenavir.
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Fosamprenavir.
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Fosamprenavir.
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Fosamprenavir.
TroglitazoneThe therapeutic efficacy of Troglitazone can be decreased when used in combination with Fosamprenavir.
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Fosamprenavir.
UdenafilThe metabolism of Udenafil can be decreased when combined with Fosamprenavir.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Fosamprenavir.
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Fosamprenavir.
VandetanibThe metabolism of Vandetanib can be decreased when combined with Fosamprenavir.
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Fosamprenavir.
VardenafilThe metabolism of Vardenafil can be decreased when combined with Fosamprenavir.
VemurafenibThe metabolism of Vemurafenib can be decreased when combined with Fosamprenavir.
VenlafaxineThe metabolism of Fosamprenavir can be decreased when combined with Venlafaxine.
VerapamilThe metabolism of Fosamprenavir can be decreased when combined with Verapamil.
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Fosamprenavir.
VilanterolThe metabolism of Vilanterol can be decreased when combined with Fosamprenavir.
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Fosamprenavir.
VildagliptinThe therapeutic efficacy of Vildagliptin can be decreased when used in combination with Fosamprenavir.
VinblastineThe metabolism of Vinblastine can be decreased when combined with Fosamprenavir.
VincristineThe metabolism of Vincristine can be decreased when combined with Fosamprenavir.
VindesineThe serum concentration of Vindesine can be increased when it is combined with Fosamprenavir.
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Fosamprenavir.
VismodegibThe metabolism of Vismodegib can be decreased when combined with Fosamprenavir.
VogliboseThe therapeutic efficacy of Voglibose can be decreased when used in combination with Fosamprenavir.
VoriconazoleThe serum concentration of the active metabolites of Fosamprenavir can be increased when Fosamprenavir is used in combination with Voriconazole.
VoriconazoleThe metabolism of Voriconazole can be decreased when combined with Fosamprenavir.
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Fosamprenavir.
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Fosamprenavir.
YohimbineThe metabolism of Yohimbine can be decreased when combined with Fosamprenavir.
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Fosamprenavir.
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Fosamprenavir.
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Fosamprenavir.
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Fosamprenavir.
ZileutonThe metabolism of Zileuton can be decreased when combined with Fosamprenavir.
ZiprasidoneThe metabolism of Fosamprenavir can be decreased when combined with Ziprasidone.
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Fosamprenavir.
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Fosamprenavir.
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Fosamprenavir.
ZopicloneThe metabolism of Zopiclone can be decreased when combined with Fosamprenavir.
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Fosamprenavir.
Food Interactions
  • Avoid alcohol, especially with the oral solution since it contains propylene glycol which competes with alcohol for alcohol dehydrogenase metabolism.
  • Take with or without food, however avoid lipid-rich meals.
  • Vitamin E increases fosamprenavir bioavailability.

Targets

Kind
Protein
Organism
Human immunodeficiency virus 1
Pharmacological action
yes
Actions
inhibitor
General Function:
Aspartic-type endopeptidase activity
Specific Function:
Not Available
Gene Name:
pol
Uniprot ID:
Q72874
Molecular Weight:
10778.7 Da
References
  1. Hoffman RM, Umeh OC, Garris C, Givens N, Currier JS: Evaluation of sex differences of fosamprenavir (with and without ritonavir) in HIV-infected men and women. HIV Clin Trials. 2007 Nov-Dec;8(6):371-80. [PubMed:18042502 ]
  2. Furfine ES, Baker CT, Hale MR, Reynolds DJ, Salisbury JA, Searle AD, Studenberg SD, Todd D, Tung RD, Spaltenstein A: Preclinical pharmacology and pharmacokinetics of GW433908, a water-soluble prodrug of the human immunodeficiency virus protease inhibitor amprenavir. Antimicrob Agents Chemother. 2004 Mar;48(3):791-8. [PubMed:14982766 ]
  3. Sension M: Initial therapy for human immunodeficiency virus: broadening the options. HIV Clin Trials. 2004 Mar-Apr;5(2):99-111. [PubMed:15116286 ]
  4. Wood R, Arasteh K, Stellbrink HJ, Teofilo E, Raffi F, Pollard RB, Eron J, Yeo J, Millard J, Wire MB, Naderer OJ: Six-week randomized controlled trial to compare the tolerabilities, pharmacokinetics, and antiviral activities of GW433908 and amprenavir in human immunodeficiency virus type 1-infected patients. Antimicrob Agents Chemother. 2004 Jan;48(1):116-23. [PubMed:14693528 ]
  5. Wire MB, Shelton MJ, Studenberg S: Fosamprenavir : clinical pharmacokinetics and drug interactions of the amprenavir prodrug. Clin Pharmacokinet. 2006;45(2):137-68. [PubMed:16485915 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Wire MB, Shelton MJ, Studenberg S: Fosamprenavir : clinical pharmacokinetics and drug interactions of the amprenavir prodrug. Clin Pharmacokinet. 2006;45(2):137-68. [PubMed:16485915 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Comments
comments powered by Disqus
Drug created on June 30, 2007 11:17 / Updated on September 28, 2016 03:41