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Identification
NameSodium bicarbonate
Accession NumberDB01390
TypeSmall Molecule
GroupsApproved
Description

Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.

Structure
Thumb
Synonyms
Baking soda
Bicarbonate of soda
Carbonic acid monosodium salt
e 500
e-500
e500
NaHCO3
Natriumhydrogenkarbonat
Sodium acid carbonate
Sodium bicarbonate
Sodium hydrogen carbonate
Sodium hydrogencarbonate
External Identifiers Not Available
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
800 Sodium Bicarbonate Powderpowder for solution650 gdialysisBaxter Corporation1988-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Bibagpowder for solution650 gdialysisFresenius Medical Care North America2009-12-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Bicarb Hemodial Conc 81.25gm/lliquid81.25 gBicarbolyte Corporation1986-12-311998-06-08Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Bicarbolyte Bicar Hemodialysis Concliquid72 gBicarbolyte Corporation1986-12-311998-06-08Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Bicarbonate Conc Mb-330 Pwr 650mg/pckpowder650 gdialysisRenal Systems, Division Of Minntech Corp.1985-12-311998-11-02Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Bicarbonate Concentrate 4105liquid80.68 gdialysisBaxter Corporation1988-12-312002-08-01Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Bicarbonate Concentrate B38solution80.7 gdialysisChief Medical Supplies Ltd2005-07-04Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Bicarbonate Concentrate D17000solution81.3 gdialysisBaxter Corporation1986-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Bicartpowder1250 gdialysisBaxter Corporation2013-10-22Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Bicartpowder720 gdialysisBaxter Corporation2013-09-26Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Bicartpowder650 gdialysisBaxter Corporation1990-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Biflexy 1100powder for solution1100 gdialysisBellco SrlNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Biflexy 750powder for solution750 gdialysisBellco SrlNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Biflexy 900powder for solution900 gdialysisBellco SrlNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
D12057powder for solution650 gdialysisBio Pharm Inc.1988-12-311996-09-09Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Hema Bp-38powder6 kgdialysisChief Medical Supplies Ltd2006-07-03Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Hemacartpowder for solution650 gdialysisChief Medical Supplies Ltd2009-12-21Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Naturalyte Dry Pack for Bicarbonate Dialysispowder650 gdialysisFresenius Medical Care North America1998-04-14Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Naturalyte Sodium Bicarbonate Liquid Concentrateliquid81.25 gdialysisFresenius Medical Care Canada Inc1997-04-14Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Neutinjection.2 g/5mLintravenousGeneral Injectables and Vaccines, Inc2014-07-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Neut Sodium Bicarbonateinjection, solution.2 g/5mLintravenousHospira, Inc.2005-08-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonateinjection, solution84 mg/mLintravenousCardinal Health1985-05-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonateinjection, solution84 mg/mLintravenousHospira, Inc.1985-05-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonateinjection84 mg/mLintravenousInternational Medication Systems, Limited2000-06-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonatesolution84 mg/mLparenteralOnpharma, Inc.2010-07-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonateinjection, solution84 mg/mLintravenousCardinal Health1985-04-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonateinjection, solution84 mg/mLintravenousMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2010-05-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonateinjection84 mg/mLparenteralAmphastar Pharmaceuticals, Inc.2000-06-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonateinjection.9 meq/mLintravenousGeneral Injectables & Vaccines, Inc.2011-03-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonatesolution42 mg/mLintravenousAPP Pharmaceuticals, LLC2000-08-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonateinjection, solution84 mg/mLintravenousHospira, Inc.1984-04-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonateinjection, solution1 meq/mLintravenousGeneral Injectables & Vaccines, Inc2010-08-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonateinjection, solution84 mg/mLintravenousFresenius Kabi USA, LLC2000-08-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonateinjection, solution84 mg/mLintravenousHospira, Inc.1985-04-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonateinjection, solution44.6 meq/50mLintravenousGeneral Injectables & Vaccines, Inc2010-08-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonateinjection, solution84 mg/mLintravenousREMEDYREPACK INC.2015-03-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonateinjection, solution1 meq/mLintravenousGeneral Injectables & Vaccines, Inc2010-08-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonateinjection, solution84 mg/mLintravenousUs Med Source, Llc2014-07-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonateinjection, solution42 mg/mLintravenousHospira, Inc.1984-01-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonateinjection, solution42 mg/mLintravenousCardinal Health1984-01-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonateinjection, solution84 mg/mLintravenousCardinal Health1985-04-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonateinjection, solution75 mg/mLintravenousHospira, Inc.1985-02-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonateinjection, solution42 mg/mLintravenousGeneral Injectables & Vaccines, Inc2010-03-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonateinjection, solution84 mg/mLintravenousCardinal Health1985-04-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonate 5% Inj 50mg/ml USPliquid50 mgintravenousMcgaw Inc.1993-12-311997-08-15Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sodium Bicarbonate 5% Inj 5gm/100ml USPsolution5 gintravenousBaxter Corporation1991-12-312011-05-10Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sodium Bicarbonate Dry Concentrate Ro9504powder for solution672 gdialysisGenpharm Ulc1990-12-312003-07-23Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sodium Bicarbonate Dry Concentrate Rx002cpowder650 gdialysisGenpharm Ulc1996-10-102004-07-30Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sodium Bicarbonate Inj 4.2%liquid42 mgintravenousInternational Medication Systems Ltd.1971-12-311997-08-15Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sodium Bicarbonate Inj 4.2% Infant USPsolution42 mgintravenousHospira Healthcare Corporation1987-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sodium Bicarbonate Inj 7.5%solution75 mgintravenousHospira Healthcare Corporation1979-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sodium Bicarbonate Inj 7.5%liquid75 mgintravenousInternational Medication Systems Ltd.1971-12-311997-08-15Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sodium Bicarbonate Inj 8.4%liquid84 mgintravenousInternational Medication Systems Ltd.1971-12-311997-08-15Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sodium Bicarbonate Inj 8.4%solution84 mgintravenousHospira Healthcare Corporation1974-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sodium Bicarbonate Injection 75mg/mlsolution75 mgintravenousAstrazeneca Canada Inc1986-12-312004-10-14Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sodium Bicarbonate Injection 84mg/mlliquid84 mgintravenousAstrazeneca Canada Inc1986-12-312004-02-27Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sodium Bicarbonate USP for Hemodialysis D12276powder650 gdialysisBaxter Corporation1996-09-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sol-cart Bpowder for solution1100 gdialysisB. Braun Avitum AgNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sol-cart Bpowder for solution760 gdialysisB. Braun Avitum AgNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sol-cart Bpowder for solution650 gdialysisB. Braun Avitum AgNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vivia Bicarbpowder for solution750 gdialysisBaxter CorporationNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Sodium Bicarbonateinjection, solution75 mg/mLintravenousHospira, Inc.2012-04-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonateinjection, solution1 meq/mLintravenousGeneral Injectables & Vaccines, Inc2010-08-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonateinjection, solution84 mg/mLintravenousHospira, Inc.2012-04-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
After Bite The Itch Eraserliquid50 mg/mLtopicalTender Corporation2014-09-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
After Bite The Itch Eraser Kidsliquid5 g/100gtopicalTender Corporation2014-11-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Anti-empacholiquid525 mg/15mLoralMenper Distributors, Inc.2012-02-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Arm and Hammer Baking Sodapowder, for solution1 g/goralChurch & Dwight Co., Inc.2000-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Assured Bug Bite Reliefliquid5 g/100gtopicalShanghai Weierya Daily Chemicals Factory2015-11-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Baking Soda USPpowder100 %oralRegal Pharms, Division Of Bradcan Corporation1987-12-311996-12-16Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Brioschi Effervescent Antacidgranule, effervescent1.02 g/5goralNeobourne Pharma Lp2015-06-302016-02-06Us 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Brioschi Effervescent Antacid - 1.8gm/6gmpowder (effervescent)1.8 goralBrioschi, Inc.1998-05-142003-02-14Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Brioschi Effervescent Antacid Pwr 280.3mg/gmpowder (effervescent)269 mgoralBrioschi, Inc.1910-12-312003-02-14Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
De LA Cruz Desempacholiquid525 mg/15mLoralDLC Laboratories, Inc.2012-08-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
De LA Cruz Sodium Bicarbonate Antacidpowder2.6 g/2.6goralDLC Laboratories, Inc.2013-09-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Ecodent Ultimate Essential Mouthcare Sparkling Clean Mintliquid25 mg/mLoralLotus Brands, Inc.2013-06-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Ecodent Ultimate Essential Mouthcare Spicy-cool Cinnamonliquid25 mg/mLoralLotus Brands, Inc.2013-06-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Goongsecret Calming Bath Oriental Formula for Babiespowder165 g/300gtopical0to7 Inc2013-07-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Humco Sodium Bicarbonatepowder1000 mg/goralHumco Holding Group, Inc.1998-03-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Skin Protectantliquid5 g/100gtopicalShanghai Kejing Cleaning Products Co., Ltd.2016-01-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonatetablet, orally disintegrating650 mg/1oralRising Pharmaceuticals, Inc.2012-06-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonatetablet650 mg/1oralCardinal Health2011-06-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonatepowder100 %oral; topicalLab Valmo EnregistrÉ, Division Of Technilab Inc.1981-12-311999-09-17Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sodium Bicarbonatetablet650 mg/1oralMirror Pharmaceuticals LLC2011-01-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonatetablet650 mg/1oralRugby Laboratories, Inc.2010-03-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonatetablet, orally disintegrating650 mg/1oralAvera Mc Kennan Hospital2015-03-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonatetablet325 mg/1oralRugby Laboratories, Inc.2010-04-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonate Antacidtablet650 mg/1oralRugby Laboratories2015-03-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonate Antacidtablet325 mg/1oralRugby Laboratories2015-03-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonate Antacidtablet650 mg/1oralCardinal Health2010-03-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sodium Bicarbonate Tab 300mgtablet300 mgoralD.C. Labs Limited1951-12-312003-07-11Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sodium Bicarbonate Tab 600mgtablet600 mgoralD.C. Labs Limited1951-12-312003-07-11Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
The Itch Eraser Sensitivecream50 mg/gtopicalTender Corporation2015-11-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
Alka Seltzer EvtMiles Canada Inc. Consumer Health Care Division
Alka Seltzer FlavouredMiles Canada Inc. Consumer Health Care Division
Alka-seltzerBayer Inc Consumer Care
Alka-seltzer FlavouredBayer Inc Consumer Care
Alka-seltzer Flavoured - EvtBayer Inc Consumer Care
Alka-seltzer GoldBayer Health Care Consumer Care
Bc-I Concentrate PwrRenal Systems, Division Of Minntech Corp.
Bicarbolyte Bicar Hemodialysis ConcBicarbolyte Corporation
Bicarbolyte Bicar Hemodiaylsis ConcBicarbolyte Corporation
Bicarbonate Chloride D12052Baxter Corporation
Bicarbonate Concentrate D16000Baxter Corporation
Bicarbonate Concentrate D16001Baxter Corporation
Bicarbonate Concentrate No 4202 LiqWestern Dialysis Supplies Ltd.
Bicart Select Combi-pakBaxter Corporation
BicaruvasProsana Distribuciones, S.A. De C.V.
Brioschi Childrens Effervescent AntacidBrioschi Pharmaceuticals International, Llc
Brioschi Effervescent AntacidBrioschi Pharmaceuticals International, Llc
Bromo SeltzerTower Laboratories Ltd
Ceo-twoBeutlich Pharmaceuticals, LLC
Citrocarbonate Eff PwsRoberts Pharmaceutical Canada Inc.
Effervescent Pain ReliefWestern Family Foods, Inc.
Effervescent Pain Relief Fast ReliefDeseret Laboratories, Inc.
Effervescent Pain Relief Fast Relief Fast ReliefMajor Pharmaceuticals
EstomarolLaboratorios Imperiales, S.A. De C.V.
Gavilyte - C TmGAVIS Pharmaceuticals, LLC
Gavilyte - NGAVIS Pharmaceuticals, LLC
Gavilyte G TmGAVIS Pharmaceuticals, LLC
Gingera Effervescent AntacidBrioschi Pharmaceuticals International, Llc
GolytelyBraintree Laboratories, Inc.
InonSato Pharmaceutical Co., Ltd.
Kettle Neti PotCardinal Health 414, Llc
Medique Medi SeltzerUnifirst First Aid Corporation
Neutra-seltzerTeva Canada Limited
NulytelyPhysicians Total Care, Inc.
Ohta's Isan Stomach PowderMaizun Calber (Canada) Ltd.
Ohtas Isan AntacidOhta's Isan Co., Ltd
Omeprazole and Sodium BicarbonatePar Pharmaceutical Inc.
Omeprazole/sodium BicarbonatePrasco, Laboratories
Ora Rinse LiqThompson Mckay Pharms Ltd.
Pain Relief Fast ReliefSelect Brand
Peg-3350 and ElectrolytesAffordable Pharmaceuticals, LLC
Peg-3350, Sodium Chloride, Sodium Bicarbonate and Potassium ChlorideAffordable Pharmaceuticals, LLC
Picot Plus EffervescentBristol Myers Squibb De Mexico, S. De R.L. De C.V.
Pleo Alkala AntacidSanum Kehlbeck Gmb H & Co. Kg
Polyethylene Glycol 3350 and ElectrolytesMylan Pharmaceuticals Inc.
Polyethylene Glycol 3350, Sodium Chloride, Sodium Bicarbonate and Potassium Chloride - UnflavoredStrides Arcolab Limited
Polyethylene Glycol 3350, Sodium Chloride, Sodium Bicarbonate and Potassium Chloride With Lemon FlavorStrides Arcolab Limited
Polyethylene Glycol 3350, Sodium Chloride, Sodium Bicarbonate and Potassium Chloride With Orange FlavorStrides Arcolab Limited
Polyethylene Glycol-3350 and ElectrolytesNovel Laboratories, Inc.
Polyethylene Glycol-3350 and Electrolytes With Flavor PackNovel Laboratories, Inc.
Polyethylene Glycol-3350, Sodium Chloride, Potassium Chloride and Sodium BicarbonateNovel Laboratories, Inc.
Premier Value Antacid and Pain Relief MedicineChain Drug Consortium, LLC
Prismasol Bgk2/3.5Gambro Renal Products Inc.
Prismasol Bgk4/2.5Gambro Renal Products Inc.
Prismasol Bgk4/3.5Gambro Renal Products Inc.
R04940 LiqBdh Inc.
Refill Saline PacketsCVS Pharmacy
Relief Otc AntacidTummy Company, Inc.
Sal De Uvas PicotBristol Myers Squibb De Mexico, S. De R.L. De C.V.
Saline RefillsCardinal Health 414, Llc
Saline WashTarget Corporation
SinucleanseAscent Consumer Products, Inc.
Sinucleanse Neti-potAscent Consumer Products, Inc.
Sinucleanse SqueezeAscent Consumer Products, Inc.
Sinus WashCVS Pharmacy
Sodium Bicarbonate-chloride Dry ConcentrateGenpharm Ulc
Sodium Bicarbonate-chloride Dry Concentrate R04955Genpharm Ulc
Sodium Bicarbonate-chloride Liquid Concentrate Ro4941Genpharm Ulc
Stomachin AntacidChang Kuo Chou Pharmaceutical Co. Ltd.
Trilyte With Flavor PacksWallace Pharmaceuticals Inc.
Vida Mia Pain ReliefNavarro Discount Pharmacies, LLC
Well At WalgreensWalgreen Company
Zee-seltzer Antacid and Pain RelieverZEE MEDICAL
ZegeridPhysicians Total Care, Inc.
Zegerid OtcMSD Consumer Care, Inc.
SaltsNot Available
CategoriesNot Available
UNII8MDF5V39QO
CAS number144-55-8
WeightAverage: 84.0066
Monoisotopic: 83.982338573
Chemical FormulaCHNaO3
InChI KeyInChIKey=UIIMBOGNXHQVGW-UHFFFAOYSA-M
InChI
InChI=1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1
IUPAC Name
sodium hydrogen carbonate
SMILES
[Na+].OC([O-])=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as organic carbonic acids and derivatives. These are compounds comprising the organic carbonic acid or a derivative thereof.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassOrganic carbonic acids and derivatives
Sub ClassNot Available
Direct ParentOrganic carbonic acids and derivatives
Alternative Parents
Substituents
  • Carbonic acid derivative
  • Monocarboxylic acid or derivatives
  • Hydrocarbon derivative
  • Organic alkali metal salt
  • Organic sodium salt
  • Organic salt
  • Organooxygen compound
  • Organic zwitterion
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Pharmacology
IndicationSodium bicarbonate is used for the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Also is indicated in severe diarrhea which is often accompanied by a significant loss of bicarbonate. Further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturateprotein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of blood pigments.
PharmacodynamicsIntravenous sodium bicarbonate therapy increases plasma bicarbonate, buffers excess hydrogen ion concentration, raises blood pH and reverses the clinical manifestations of acidosis.
Mechanism of actionSodium bicarbonate is a systemic alkalizer, which increases plasma bicarbonate, buffers excess hydrogen ion concentration, and raises blood pH, thereby reversing the clinical manifestations of acidosis. It is also a urinary alkalizer, increasing the excretion of free bicarbonate ions in the urine, thus effectively raising the urinary pH. By maintaining an alkaline urine, the actual dissolution of uric acid stones may be accomplished. Sodium bicarbonate acts as an antacid and reacts chemically to neutralize or buffer existing quantities of stomach acid but has no direct effect on its output. This action results in increased pH value of stomach contents, thus providing relief of hyperacidity symptoms. [PharmGKB]
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9292
Blood Brain Barrier+0.936
Caco-2 permeable-0.5321
P-glycoprotein substrateNon-substrate0.8785
P-glycoprotein inhibitor INon-inhibitor0.9903
P-glycoprotein inhibitor IINon-inhibitor0.9931
Renal organic cation transporterNon-inhibitor0.9563
CYP450 2C9 substrateNon-substrate0.8326
CYP450 2D6 substrateNon-substrate0.9017
CYP450 3A4 substrateNon-substrate0.8144
CYP450 1A2 substrateNon-inhibitor0.9053
CYP450 2C9 inhibitorNon-inhibitor0.9337
CYP450 2D6 inhibitorNon-inhibitor0.9401
CYP450 2C19 inhibitorNon-inhibitor0.9461
CYP450 3A4 inhibitorNon-inhibitor0.9774
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9911
Ames testNon AMES toxic0.9285
CarcinogenicityNon-carcinogens0.5181
BiodegradationReady biodegradable0.9636
Rat acute toxicity1.9204 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9596
hERG inhibition (predictor II)Non-inhibitor0.9866
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Liquidtopical50 mg/mL
Liquidtopical5 g/100g
Tablet (effervescent)oral
Tablet, effervescentoral
Powder, for solutionoral1 g/g
Powderoral100 %
Powder for solutiondialysis
Powder for solutiondialysis650 g
Liquid81.25 g
Liquid
Liquid72 g
Liquiddialysis80.68 g
Solutiondialysis80.7 g
Solutiondialysis
Solutiondialysis81.3 g
Liquiddialysis
Powderdialysis1250 g
Powderdialysis650 g
Powderdialysis720 g
Kit; powder for solutiondialysis
Powder for solutiondialysis900 g
Granule, effervescentoral
Granule, effervescentoral1.02 g/5g
Powder (effervescent)oral1.8 g
Powder (effervescent)oral269 mg
Granulesoral
Suppositoryrectal
Powder (effervescent)oral
Liquidoral525 mg/15mL
Powderoral2.6 g/2.6g
Liquidoral25 mg/mL
Powdertopical165 g/300g
Powderdialysis6 kg
Powderoral1000 mg/g
Granuleoral
Liquiddialysis81.25 g
Injectionintravenous.2 g/5mL
Injection, solutionintravenous.2 g/5mL
Powder
Liquid; mouthwash/garglerefer (see dosage form)
Solutionintravenous
Liquidoral
Injectionintravenous.9 meq/mL
Injectionintravenous84 mg/mL
Injectionparenteral84 mg/mL
Injection, solutionintravenous1 meq/mL
Injection, solutionintravenous42 mg/mL
Injection, solutionintravenous44.6 meq/50mL
Injection, solutionintravenous75 mg/mL
Injection, solutionintravenous84 mg/mL
Powderoral; topical100 %
Solutionintravenous42 mg/mL
Solutionparenteral84 mg/mL
Tablet, orally disintegratingoral650 mg/1
Liquidintravenous50 mg
Solutionintravenous5 g
Tabletoral325 mg/1
Tabletoral650 mg/1
Powder for solutiondialysis672 g
Liquidintravenous42 mg
Solutionintravenous42 mg
Liquidintravenous75 mg
Solutionintravenous75 mg
Liquidintravenous84 mg
Solutionintravenous84 mg
Tabletoral300 mg
Tabletoral600 mg
Powderdialysis
Powder for solutiondialysis1100 g
Powder for solutiondialysis760 g
Powderoral
Creamtopical50 mg/g
Powder, for solutionnasogastric; oral
Powder for solutiondialysis750 g
Kitnasal
Powder, for solutionnasal
Powder, for solutionoral
Powder, for suspensionoral
Capsuleoral
Prices
Unit descriptionCostUnit
Golytely 236 gm Solution28.0USD bottle
Colyte 240 gm Solution26.0USD bottle
Golytely 227.1 gm Solution Packet21.85USD packet
Colyte-Flavored 240 gm Solution18.17USD bottle
Elliotts b solution ampule4.71USD ml
Sodium bicarb 4.2% vial1.45USD ml
Neut 4% vial0.92USD ml
Bss plus eye solution0.2USD ml
Sodium bicarb 650 mg tablet0.07USD tablet
Antacid 650 mg tablet0.05USD tablet
Antacid 325 mg tablet0.04USD tablet
Sodium bicarb 325 mg tablet0.04USD tablet
Sodium bicarb 7.5% vial0.04USD ml
Sodium bicarbonate powder0.03USD g
Sodium bicarb 8.4% vial0.02USD ml
Sodium bicarbonate 5% inj0.02USD ml
Colyte with flavor packets0.01USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting pointDecomposes around 50 °CNot Available
water solubility1E+005 mg/L (at 25 °C)MERCK INDEX (1996)
pKa6.3Not Available
Predicted Properties
PropertyValueSource
Water Solubility764.0 mg/mLALOGPS
logP-0.06ALOGPS
logP0.25ChemAxon
logS0.96ALOGPS
pKa (Strongest Acidic)6.05ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area60.36 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity20.34 m3·mol-1ChemAxon
Polarizability3.86 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

Alan B. Gancy, Rustom P. Poncha, “Production of low bulk density product from sodium bicarbonate by the use of an inert gas stream.” U.S. Patent US3984527, issued August, 1922.

US3984527
General ReferencesNot Available
External Links
ATC CodesB05CB04B05XA02
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (74 KB)
Interactions
Drug Interactions
Drug
AcepromazineSodium bicarbonate can cause a decrease in the absorption of Acepromazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Sodium bicarbonate.
AmphetamineThe serum concentration of Amphetamine can be increased when it is combined with Sodium bicarbonate.
AtazanavirSodium bicarbonate can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
BisacodylThe therapeutic efficacy of Bisacodyl can be decreased when used in combination with Sodium bicarbonate.
Bismuth SubcitrateThe therapeutic efficacy of Bismuth Subcitrate can be decreased when used in combination with Sodium bicarbonate.
BosutinibThe serum concentration of Bosutinib can be decreased when it is combined with Sodium bicarbonate.
BudesonideThe bioavailability of Budesonide can be decreased when combined with Sodium bicarbonate.
CaptoprilThe serum concentration of Captopril can be decreased when it is combined with Sodium bicarbonate.
CathinoneSodium bicarbonate may decrease the excretion rate of Cathinone which could result in a lower serum level and potentially a reduction in efficacy.
CefditorenThe serum concentration of Cefditoren can be decreased when it is combined with Sodium bicarbonate.
CefpodoximeThe serum concentration of Cefpodoxime can be decreased when it is combined with Sodium bicarbonate.
CefuroximeThe serum concentration of Cefuroxime can be decreased when it is combined with Sodium bicarbonate.
ChloroquineThe serum concentration of Chloroquine can be decreased when it is combined with Sodium bicarbonate.
CysteamineThe therapeutic efficacy of Cysteamine can be decreased when used in combination with Sodium bicarbonate.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be decreased when it is combined with Sodium bicarbonate.
DabrafenibThe serum concentration of Dabrafenib can be decreased when it is combined with Sodium bicarbonate.
DasatinibSodium bicarbonate can cause a decrease in the absorption of Dasatinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Sodium bicarbonate.
DexmethylphenidateSodium bicarbonate can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.
ElvitegravirThe serum concentration of Elvitegravir can be decreased when it is combined with Sodium bicarbonate.
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Sodium bicarbonate.
FlecainideSodium bicarbonate may decrease the arrhythmogenic activities of Flecainide.
FosinoprilThe serum concentration of Fosinopril can be decreased when it is combined with Sodium bicarbonate.
GabapentinThe serum concentration of Gabapentin can be decreased when it is combined with Sodium bicarbonate.
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Sodium bicarbonate.
HexamethylenetetramineThe therapeutic efficacy of Hexamethylenetetramine can be decreased when used in combination with Sodium bicarbonate.
HyoscyamineThe serum concentration of Hyoscyamine can be decreased when it is combined with Sodium bicarbonate.
Iron DextranSodium bicarbonate can cause a decrease in the absorption of Iron Dextran resulting in a reduced serum concentration and potentially a decrease in efficacy.
IsoniazidSodium bicarbonate can cause a decrease in the absorption of Isoniazid resulting in a reduced serum concentration and potentially a decrease in efficacy.
ItraconazoleThe serum concentration of Itraconazole can be decreased when it is combined with Sodium bicarbonate.
KetoconazoleThe serum concentration of Ketoconazole can be decreased when it is combined with Sodium bicarbonate.
LedipasvirThe serum concentration of Ledipasvir can be decreased when it is combined with Sodium bicarbonate.
LithiumSodium bicarbonate may increase the excretion rate of Lithium which could result in a higher serum level.
MecamylamineThe serum concentration of Mecamylamine can be increased when it is combined with Sodium bicarbonate.
MemantineThe serum concentration of Memantine can be increased when it is combined with Sodium bicarbonate.
MesalazineThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Sodium bicarbonate.
MethylphenidateSodium bicarbonate can cause an increase in the absorption of Methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.
NilotinibThe serum concentration of Nilotinib can be decreased when it is combined with Sodium bicarbonate.
OxytetracyclineSodium bicarbonate can cause a decrease in the absorption of Oxytetracycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
PazopanibThe serum concentration of Pazopanib can be decreased when it is combined with Sodium bicarbonate.
PenicillamineThe serum concentration of Penicillamine can be decreased when it is combined with Sodium bicarbonate.
Polystyrene sulfonateThe risk or severity of adverse effects can be increased when Sodium bicarbonate is combined with Polystyrene sulfonate.
PravastatinThe serum concentration of Pravastatin can be decreased when it is combined with Sodium bicarbonate.
QuinidineSodium bicarbonate may decrease the excretion rate of Quinidine which could result in a lower serum level and potentially a reduction in efficacy.
QuinineThe serum concentration of Quinine can be increased when it is combined with Sodium bicarbonate.
RilpivirineThe serum concentration of Rilpivirine can be decreased when it is combined with Sodium bicarbonate.
RiociguatThe serum concentration of Riociguat can be decreased when it is combined with Sodium bicarbonate.
SotalolThe serum concentration of Sotalol can be decreased when it is combined with Sodium bicarbonate.
SulpirideThe serum concentration of Sulpiride can be decreased when it is combined with Sodium bicarbonate.
TriethylenetetramineSodium bicarbonate can cause a decrease in the absorption of Triethylenetetramine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Food InteractionsNot Available

Targets

1. Hydrogen ions

Kind: Small molecule

Organism:

Pharmacological action: yes

Actions: neutralizer

Components

Name UniProt ID Details

References:

  1. Nudel DB, Peterson BJ, Buckley BJ, Kaplan NA, Weinhaouse E, Gootman N: Comparative effects of bicarbonate and dichloroacetate in newborn swine with hypoxic lactic acidosis. Dev Pharmacol Ther. 1990;15(2):86-93. Pubmed
  2. Roderick P, Willis NS, Blakeley S, Jones C, Tomson C: Correction of chronic metabolic acidosis for chronic kidney disease patients. Cochrane Database Syst Rev. 2007 Jan 24;(1):CD001890. Pubmed
  3. Balali-Mood M, Balali-Mood K: Neurotoxic disorders of organophosphorus compounds and their managements. Arch Iran Med. 2008 Jan;11(1):65-89. Pubmed
  4. Vaughan-Jones RD, Spitzer KW: Role of bicarbonate in the regulation of intracellular pH in the mammalian ventricular myocyte. Biochem Cell Biol. 2002;80(5):579-96. Pubmed
  5. Levraut J, Giunti C, Ciebiera JP, de Sousa G, Ramhani R, Payan P, Grimaud D: Initial effect of sodium bicarbonate on intracellular pH depends on the extracellular nonbicarbonate buffering capacity. Crit Care Med. 2001 May;29(5):1033-9. Pubmed

Transporters

1. Electrogenic sodium bicarbonate cotransporter 1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Electrogenic sodium bicarbonate cotransporter 1 Q9Y6R1 Details

References:

  1. Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. Pubmed
  2. Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. Pubmed
  3. Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Minerva Urol Nefrol. 2003 Jun;55(2):131-40. Pubmed
  4. Soleimani M: Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. J Nephrol. 2002 Mar-Apr;15 Suppl 5:S32-40. Pubmed

2. Sodium bicarbonate cotransporter 3

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Sodium bicarbonate cotransporter 3 Q9Y6M7 Details

References:

  1. Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. Pubmed
  2. Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. Pubmed
  3. Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Minerva Urol Nefrol. 2003 Jun;55(2):131-40. Pubmed
  4. Soleimani M: Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. J Nephrol. 2002 Mar-Apr;15 Suppl 5:S32-40. Pubmed

3. Electroneutral sodium bicarbonate exchanger 1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Electroneutral sodium bicarbonate exchanger 1 Q2Y0W8 Details

References:

  1. Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. Pubmed
  2. Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. Pubmed
  3. Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Minerva Urol Nefrol. 2003 Jun;55(2):131-40. Pubmed
  4. Soleimani M: Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. J Nephrol. 2002 Mar-Apr;15 Suppl 5:S32-40. Pubmed

4. Electrogenic sodium bicarbonate cotransporter 4

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Electrogenic sodium bicarbonate cotransporter 4 Q9BY07 Details

References:

  1. Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. Pubmed
  2. Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. Pubmed
  3. Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Minerva Urol Nefrol. 2003 Jun;55(2):131-40. Pubmed
  4. Soleimani M: Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. J Nephrol. 2002 Mar-Apr;15 Suppl 5:S32-40. Pubmed

5. Sodium-driven chloride bicarbonate exchanger

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Sodium-driven chloride bicarbonate exchanger Q6U841 Details

References:

  1. Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. Pubmed
  2. Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. Pubmed
  3. Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Minerva Urol Nefrol. 2003 Jun;55(2):131-40. Pubmed
  4. Soleimani M: Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. J Nephrol. 2002 Mar-Apr;15 Suppl 5:S32-40. Pubmed

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Drug created on July 08, 2007 10:59 / Updated on September 16, 2013 17:14