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Showing drug card for Sodium bicarbonate (DB01390)

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Version 2.5
Creation Date 2007-07-08 16:59:29
Update Date 2009-04-16 16:48:24
Primary Accession Number DB01390
Secondary Accession Number Not Available
Name Sodium bicarbonate
Drug Type
  • Approved
  • Small Molecule
Description A white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
Synonyms
  1. Bicarbonate of soda
  2. Carbonic acid monosodium salt
  3. Sodium acid carbonate
  4. Sodium hydrocarbonate
  5. Sodium hydrogen carbonate
  6. Sodium hydrogencarbonate
Brand Names
  1. 800 Sodium Bicarbonate Powder
  2. Acidosan
  3. BSS plus
  4. Baros
  5. Citrocarbonate
  6. Co-lav
  7. Colovage
  8. Colyte
  9. E-Z-EM Prep Lyte
  10. Elliotts B solution
  11. Endosol extra
  12. Glycoprep
  13. Go-evac
  14. Golytely
  15. Gripe water
  16. Hema BP-38
  17. Meylon
  18. Natrum bicarbonicum
  19. Neut
  20. Nulytely
  21. OCL
  22. Peg-lyte
  23. Sandoz sodium bicarbonate
  24. Sodium bicarbonate in plastic container
  25. Sodium bicarbonate liquid concentrate
Brand Mixtures
  1. Alka-Seltzer Flavoured (Acetylsalicylic Acid + Citric Acid + Sodium Bicarbonate)
  2. Amo Endosol Extra (alcium Chloride + Dextrose + Glutathione Disulfide + Magnesium Chloride + Potassium Chloride + Sodium Bicarbonate + Sodium Chloride + Sodium Phosphate Dibasic)
  3. Artrol (Antipyrine + Cimicifuga Racemosa + Methyl Salicylate + Sodium Bicarbonate + Sodium Salicylate + Taraxacum Officinale Weber)
  4. Baros Effervescent Granules (Sodium Bicarbonate + Tartaric Acid)
  5. Bicarbonate Concentrate D16000 (Sodium Bicarbonate + Sodium Chloride)
  6. Bicarbonate Concentrate D16001 (Sodium Bicarbonate + Sodium Chloride)
  7. E-Z-Gas 2 (Citric Acid + Sodium Bicarbonate)
  8. Woodward's Gripe Water (Oil of Dill + Sodium Bicarbonate)
Chemical IUPAC Name sodium hydrogen carbonate
Chemical Formula CHNaO3
Chemical Structure Structure
CAS Registry Number 144-55-8
InChI Identifier InChI=1/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1/fCHO3.Na/h2H;/q-1;m
InChI Key UIIMBOGNXHQVGW-PAJBJYNQCH
KEGG Drug D01203 Link Image
KEGG Compound C12603 Link Image
PubChem Compound 8953 Link Image
PubChem Substance 7848266 Link Image
ChEBI ID 32139 Link Image
PharmGKB ID PA451375 Link Image
HET ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 02280884 Link Image
RxList Link http://www.rxlist.com/cgi/generic/sodbic.htm Link Image
PDRhealth Link Not Available
Wikipedia Link http://en.wikipedia.org/wiki/Sodium_bicarbonate Link Image
FDA Label Not Available
Material Safety Data Sheet (MSDS)
Synthesis Reference Not Available
Average Molecular Weight 84.0066
Monoisotopic Molecular Weight 83.9823
State Solid
Melting Point Decomposes around 50 oC
Experimental Water Solubility 100 mg/mL at 25 oC [MERCK INDEX (1996)] Source: PhysProp
Predicted Water Solubility 7.64e+02 mg/mL Calculated using ALOGPS
Experimental LogP/Hydrophobicity Not Available Source: PhysProp
Predicted LogP -0.05 Calculated using ALOGPS
Experimental LogS Not Available
Predicted LogS 0.96 Calculated using ALOGPS
Experimental Caco2 Permeability Not Available
pKa/Isoelectric Point 6.3
Mass Spectrum Not Available
MOL File Show Link Image | Download Link Image
SDF File Show Link Image | Download Link Image
PDB File Show Link Image | Download Link Image
2D Structure
3D Structure
Experimental PDB ID Not Available
Isomeric SMILES [Na+].OC([O-])=O
Canonical SMILES [Na+].OC([O-])=O
Drug Category
  • Antidiarrheals
ATC Codes Not Available
AHFS Codes Not Available
Indication For the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Also is indicated in severe diarrhea which is often accompanied by a significant loss of bicarbonate. Further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturateprotein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of blood pigments.
Pharmacology Intravenous sodium bicarbonate therapy increases plasma bicarbonate, buffers excess hydrogen ion concentration, raises blood pH and reverses the clinical manifestations of acidosis.
Mechanism of Action Alkalizer, systemic—Increases the plasma bicarbonate, buffers excess hydrogen ion concentration, and raises blood pH, thereby reversing the clinical manifestations of acidosis. Alkalizer, urinary—Increases the excretion of free bicarbonate ions in the urine, thus effectively raising the urinary pH. By maintaining an alkaline urine, the actual dissolution of uric acid stones may be accomplished. Antacid—Reacts chemically to neutralize or buffer existing quantities of stomach acid but has no direct effect on its output. This action results in increased pH value of stomach contents, thus providing relief of hyperacidity symptoms. [PharmGKB]
Absorption Not Available
Toxicity Not Available
Protein Binding Not Available
Biotransformation Not Available
Half Life Not Available
Dosage Forms
Form Route
Liquid Oral
Powder Oral
Solution Intravenous
Solution / drops Oral
Tablet Oral
Patient Information Not Available
Contraindications Show Link Image
Interactions Show Link Image
Drug Interactions Not Available
Food Interactions Not Available
Pathways Not Available
General References
  1. Wikipedia Link Image
  2. RxList Link Image
Organisms Affected
  • Humans and other mammals

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