You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.
Identification
NameSodium bicarbonate
Accession NumberDB01390
TypeSmall Molecule
GroupsApproved
Description

Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.

Structure
Thumb
Synonyms
Baking soda
Bicarbonate of soda
Carbonic acid monosodium salt
e 500
e-500
e500
NaHCO3
Natriumhydrogenkarbonat
Sodium acid carbonate
Sodium bicarbonate
Sodium hydrogen carbonate
Sodium hydrogencarbonate
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
800 Sodium Bicarbonate Powderpowder for solution650 gdialysisBaxter Corporation1988-12-31Not applicableCanada
Bibagpowder for solution650 gdialysisFresenius Medical Care Deutchland Gmbh2009-12-10Not applicableCanada
Bicarb Hemodial Conc 81.25gm/lliquid81.25 gBicarbolyte Corporation1986-12-311998-06-08Canada
Bicarbolyte Bicar Hemodialysis Concliquid72 gBicarbolyte Corporation1986-12-311998-06-08Canada
Bicarbonate Conc Mb-330 Pwr 650mg/pckpowder650 gdialysisRenal Systems, Division Of Minntech Corp.1985-12-311998-11-02Canada
Bicarbonate Concentrate 4105liquid80.68 gdialysisBaxter Corporation1988-12-312002-08-01Canada
Bicarbonate Concentrate B38solution80.7 gdialysisChief Medical Supplies Ltd2005-07-04Not applicableCanada
Bicarbonate Concentrate D17000solution81.3 gdialysisBaxter Corporation1986-12-31Not applicableCanada
Bicartpowder1250 gdialysisBaxter Corporation2013-10-22Not applicableCanada
Bicartpowder720 gdialysisBaxter Corporation2013-09-26Not applicableCanada
Bicartpowder650 gdialysisBaxter Corporation1990-12-31Not applicableCanada
Biflexy 1100powder for solution1100 gdialysisBellco SrlNot applicableNot applicableCanada
Biflexy 750powder for solution750 gdialysisBellco SrlNot applicableNot applicableCanada
Biflexy 900powder for solution900 gdialysisBellco SrlNot applicableNot applicableCanada
D12057powder for solution650 gdialysisBio Pharm Inc.1988-12-311996-09-09Canada
Hema Bp-38powder6 kgdialysisChief Medical Supplies Ltd2006-07-03Not applicableCanada
Hemacartpowder for solution650 gdialysisChief Medical Supplies Ltd2009-12-21Not applicableCanada
Naturalyte Dry Pack for Bicarbonate Dialysispowder650 gdialysisFresenius Medical Care North America1998-04-14Not applicableCanada
Naturalyte Sodium Bicarbonate Liquid Concentrateliquid81.25 gdialysisFresenius Medical Care Canada Inc1997-04-14Not applicableCanada
Sodium Bicarbonateinjection, solution84 mg/mLintravenousMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2010-05-03Not applicableUs
Sodium Bicarbonate 5% Inj 50mg/ml USPliquid50 mgintravenousMcgaw Inc.1993-12-311997-08-15Canada
Sodium Bicarbonate 5% Inj 5gm/100ml USPsolution5 gintravenousBaxter Corporation1991-12-312011-05-10Canada
Sodium Bicarbonate Dry Concentrate Ro9504powder for solution672 gdialysisGenpharm Ulc1990-12-312003-07-23Canada
Sodium Bicarbonate Dry Concentrate Rx002cpowder650 gdialysisGenpharm Ulc1996-10-102004-07-30Canada
Sodium Bicarbonate Inj 4.2%liquid42 mgintravenousInternational Medication Systems Ltd.1971-12-311997-08-15Canada
Sodium Bicarbonate Inj 4.2% Infant USPsolution42 mgintravenousHospira Healthcare Corporation1987-12-31Not applicableCanada
Sodium Bicarbonate Inj 7.5%liquid75 mgintravenousInternational Medication Systems Ltd.1971-12-311997-08-15Canada
Sodium Bicarbonate Inj 7.5%solution75 mgintravenousHospira Healthcare Corporation1979-12-31Not applicableCanada
Sodium Bicarbonate Inj 8.4%solution84 mgintravenousHospira Healthcare Corporation1974-12-31Not applicableCanada
Sodium Bicarbonate Inj 8.4%liquid84 mgintravenousInternational Medication Systems Ltd.1971-12-311997-08-15Canada
Sodium Bicarbonate Injection 75mg/mlsolution75 mgintravenousAstrazeneca Canada Inc1986-12-312004-10-14Canada
Sodium Bicarbonate Injection 84mg/mlliquid84 mgintravenousAstrazeneca Canada Inc1986-12-312004-02-27Canada
Sodium Bicarbonate USP for Hemodialysis D12276powder650 gdialysisBaxter Corporation1996-09-10Not applicableCanada
Sol-cart Bpowder for solution1100 gdialysisB. Braun Avitum AgNot applicableNot applicableCanada
Sol-cart Bpowder for solution760 gdialysisB. Braun Avitum AgNot applicableNot applicableCanada
Sol-cart Bpowder for solution650 gdialysisB. Braun Avitum AgNot applicableNot applicableCanada
Vivia Bicarbpowder for solution750 gdialysisBaxter CorporationNot applicableNot applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Sodium Bicarbonateinjection, solution75 mg/mLintravenousHospira, Inc.2012-04-18Not applicableUs
Sodium Bicarbonateinjection, solution42 mg/mLintravenousHospira, Inc.1984-01-27Not applicableUs
Sodium Bicarbonateinjection, solution1 meq/mLintravenousGeneral Injectables & Vaccines, Inc2010-08-01Not applicableUs
Sodium Bicarbonateinjection, solution84 mg/mLintravenousHospira, Inc.2012-04-18Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
After Bite The Itch Eraserliquid50 mg/mLtopicalTender Corporation2014-09-02Not applicableUs
After Bite The Itch Eraser Kidsliquid5 g/100gtopicalTender Corporation2014-11-26Not applicableUs
Anti-empacholiquid525 mg/15mLoralMenper Distributors, Inc.2012-02-21Not applicableUs
Arm and Hammer Baking Sodapowder, for solution1 g/goralChurch & Dwight Co., Inc.2000-01-01Not applicableUs
Baking Soda USPpowder100 %oralRegal Pharms, Division Of Bradcan Corporation1987-12-311996-12-16Canada
Brioschi Effervescent Antacidgranule, effervescent1.02 g/5goralNeobourne Pharma Lp2015-06-302016-02-06Us
Brioschi Effervescent Antacid - 1.8gm/6gmpowder (effervescent)1.8 goralBrioschi, Inc.1998-05-142003-02-14Canada
Brioschi Effervescent Antacid Pwr 280.3mg/gmpowder (effervescent)269 mgoralBrioschi, Inc.1910-12-312003-02-14Canada
De LA Cruz Desempacholiquid525 mg/15mLoralDLC Laboratories, Inc.2012-08-06Not applicableUs
De LA Cruz Sodium Bicarbonate Antacidpowder2.6 g/2.6goralDLC Laboratories, Inc.2013-09-25Not applicableUs
Ecodent Ultimate Essential Mouthcare Sparkling Clean Mintliquid25 mg/mLoralLotus Brands, Inc.2013-06-01Not applicableUs
Ecodent Ultimate Essential Mouthcare Spicy-cool Cinnamonliquid25 mg/mLoralLotus Brands, Inc.2013-06-01Not applicableUs
Goongsecret Calming Bath Oriental Formula for Babiespowder165 g/300gtopical0to7 Inc2013-07-01Not applicableUs
Humco Sodium Bicarbonatepowder1000 mg/goralHumco Holding Group, Inc.1998-03-25Not applicableUs
Skin Protectantliquid5 g/100gtopicalShanghai Kejing Cleaning Products Co., Ltd.2016-01-18Not applicableUs
Sodium Bicarbonatetablet, orally disintegrating650 mg/1oralRising Pharmaceuticals, Inc.2012-06-26Not applicableUs
Sodium Bicarbonatepowder100 %oral; topicalLab Valmo EnregistrÉ, Division Of Technilab Inc.1981-12-311999-09-17Canada
Sodium Bicarbonatetablet650 mg/1oralMirror Pharmaceuticals LLC2011-01-24Not applicableUs
Sodium Bicarbonatetablet650 mg/1oralRugby Laboratories, Inc.2010-03-08Not applicableUs
Sodium Bicarbonatetablet325 mg/1oralRugby Laboratories, Inc.2010-04-21Not applicableUs
Sodium Bicarbonatetablet, orally disintegrating650 mg/1oralAvera Mc Kennan Hospital2015-03-05Not applicableUs
Sodium Bicarbonate Antacidtablet650 mg/1oralCardinal Health2010-03-08Not applicableUs
Sodium Bicarbonate Antacidtablet650 mg/1oralRugby Laboratories2015-03-25Not applicableUs
Sodium Bicarbonate Antacidtablet325 mg/1oralRugby Laboratories2015-03-25Not applicableUs
Sodium Bicarbonate Tab 300mgtablet300 mgoralD.C. Labs Limited1951-12-312003-07-11Canada
Sodium Bicarbonate Tab 600mgtablet600 mgoralD.C. Labs Limited1951-12-312003-07-11Canada
The Itch Eraser Sensitivecream50 mg/gtopicalTender Corporation2015-11-17Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Assured Bug Bite Reliefliquid5 g/100gtopicalShanghai Weierya Daily Chemicals Factory2015-11-10Not applicableUs
Neutinjection.2 g/5mLintravenousGeneral Injectables and Vaccines, Inc2014-07-31Not applicableUs
Neut Sodium Bicarbonateinjection, solution.2 g/5mLintravenousHospira, Inc.2005-08-22Not applicableUs
Sodium Bicarbonateinjection, solution84 mg/mLintravenousCardinal Health1985-05-01Not applicableUs
Sodium Bicarbonateinjection, solution84 mg/mLintravenousHospira, Inc.1985-05-01Not applicableUs
Sodium Bicarbonatetablet650 mg/1oralCardinal Health2011-06-06Not applicableUs
Sodium Bicarbonateinjection, solution42 mg/mLintravenousCardinal Health1984-01-27Not applicableUs
Sodium Bicarbonateinjection, solution42 mg/mLintravenousGeneral Injectables & Vaccines, Inc2010-03-01Not applicableUs
Sodium Bicarbonateinjection84 mg/mLintravenousInternational Medication Systems, Limited2000-06-01Not applicableUs
Sodium Bicarbonateinjection, solution84 mg/mLintravenousCardinal Health1985-04-18Not applicableUs
Sodium Bicarbonatesolution84 mg/mLparenteralOnpharma, Inc.2010-07-22Not applicableUs
Sodium Bicarbonatesolution42 mg/mLintravenousAPP Pharmaceuticals, LLC2000-08-10Not applicableUs
Sodium Bicarbonateinjection, solution84 mg/mLintravenousCardinal Health1985-04-18Not applicableUs
Sodium Bicarbonateinjection84 mg/mLparenteralAmphastar Pharmaceuticals, Inc.2000-06-01Not applicableUs
Sodium Bicarbonateinjection, solution84 mg/mLintravenousFresenius Kabi USA, LLC2000-08-10Not applicableUs
Sodium Bicarbonateinjection, solution84 mg/mLintravenousREMEDYREPACK INC.2015-03-072016-03-29Us
Sodium Bicarbonateinjection.9 meq/mLintravenousGeneral Injectables & Vaccines, Inc.2011-03-10Not applicableUs
Sodium Bicarbonateinjection, solution84 mg/mLintravenousHospira, Inc.1984-04-13Not applicableUs
Sodium Bicarbonateinjection, solution1 meq/mLintravenousGeneral Injectables & Vaccines, Inc2010-08-01Not applicableUs
Sodium Bicarbonateinjection, solution84 mg/mLintravenousHospira, Inc.1985-04-18Not applicableUs
Sodium Bicarbonateinjection, solution84 mg/mLintravenousUs Med Source, Llc2014-07-03Not applicableUs
Sodium Bicarbonateinjection, solution44.6 meq/50mLintravenousGeneral Injectables & Vaccines, Inc2010-08-01Not applicableUs
Sodium Bicarbonateinjection, solution1 meq/mLintravenousGeneral Injectables & Vaccines, Inc2010-08-01Not applicableUs
Sodium Bicarbonateinjection, solution75 mg/mLintravenousHospira, Inc.1985-02-14Not applicableUs
Sodium Bicarbonateinjection, solution84 mg/mLintravenousCardinal Health1985-04-18Not applicableUs
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
Accusol 35 K0Chief Medical Supplies Ltd
Alka SeltzerSalimex, S.A.
Alka Seltzer EvtMiles Canada Inc. Consumer Health Care Division
Alka Seltzer FlavouredMiles Canada Inc. Consumer Health Care Division
Alka-seltzerBayer Inc Consumer Care
Alka-seltzer FlavouredBayer Inc Consumer Care
Alka-seltzer Flavoured - EvtBayer Inc Consumer Care
Alka-seltzer GoldBayer Health Care Consumer Care
Alka-seltzer HeartburnBayer Health Care Llc, Consumer Care
Alka-seltzer Lemon LimeBayer Health Care Consumer Care
Alka-seltzer OriginalBayer Health Care Consumer Care
Alka-seltzer Xtra StrengthBayer Health Care Llc, Consumer Care
Amo Endosol ExtraAmo Canada Company
Baros Effervescent GranulesTyco Healthcare
Bc-I Concentrate PwrRenal Systems, Division Of Minntech Corp.
Bi-peglytePendopharm Division Of De Pharmascience Inc
Bicarbolyte Bicar Hemodialysis ConcBicarbolyte Corporation
Bicarbolyte Bicar Hemodiaylsis ConcBicarbolyte Corporation
Bicarbonate Chloride D12052Baxter Corporation
Bicarbonate Concentrate D16000Baxter Corporation
Bicarbonate Concentrate D16001Baxter Corporation
Bicarbonate Concentrate D20000Baxter Corporation
Bicarbonate Concentrate No 4202 LiqWestern Dialysis Supplies Ltd.
Bicart Select Combi-pakBaxter Corporation
BicaruvasProsana Distribuciones, S.A. De C.V.
Bicavera 1.5% GlucoseFresenius Medical Care Canada Inc
Bicavera 2.3% GlucoseFresenius Medical Care Canada Inc
Bicavera 4.25% GlucoseFresenius Medical Care Canada Inc
Bicavera Forte 1.5% GlucoseFresenius Medical Care Canada Inc
Bicavera Forte 2.3% GlucoseFresenius Medical Care Canada Inc
Bicavera Forte 4.25% GlucoseFresenius Medical Care Canada Inc
Brioschi Childrens Effervescent AntacidBrioschi Pharmaceuticals International, Llc
Brioschi Effervescent AntacidBrioschi Pharmaceuticals International, Llc
Bromo SeltzerTower Laboratories Ltd
Bss PlusAlcon Canada Inc
Ceo-twoBeutlich Pharmaceuticals, LLC
Ceo-two Bowel Evacuant SuppositoriesBeutlich L.P.
Citrocarbonate Eff PwsRoberts Pharmaceutical Canada Inc.
ColytePendopharm Division Of De Pharmascience Inc
Colyte With Flavor PacksAlaven Pharmaceutical LLC
CvsCVS Pharmacy
DialyteIamat (Inter Assoc Medic Assist Travel)
E-Z-gas 2 GranulesTherapex Division De E Z Em Canada Inc
Effervescent Antacid and Pain ReliefCardinal Health Inc.
Effervescent Pain ReliefWestern Family Foods, Inc.
Effervescent Pain Relief Fast ReliefDeseret Laboratories, Inc.
Effervescent Pain Relief Fast Relief Fast ReliefMajor Pharmaceuticals
Electropeg SolutionTechnilab Pharma Inc.
EstomarolLaboratorios Imperiales, S.A. De C.V.
Gavilyte - C TmGAVIS Pharmaceuticals, LLC
Gavilyte - NGAVIS Pharmaceuticals, LLC
Gavilyte G TmGAVIS Pharmaceuticals, LLC
Gingera Effervescent AntacidBrioschi Pharmaceuticals International, Llc
GolytelyBraintree Laboratories, Inc.
Golytely Gi Lavage SolutionBraintree Laboratories Inc.
H.E.L.P.bicelB. Braun Avitum Ag
InonSato Pharmaceutical Co., Ltd.
Jamp-electropegJamp Pharma Corporation
Jamp-electropeg With Flavour PacketJamp Pharma Corporation
JamplyteJamp Pharma Corporation
Jamplyte 280Jamp Pharma Corporation
Kettle Neti PotCardinal Health 414, Llc
Klean-prepPendopharm Division Of De Pharmascience Inc
LyteprepTherapex Division De E Z Em Canada Inc
Medique Medi SeltzerUnifirst First Aid Corporation
NavstelAlcon Canada Inc
Neutra-seltzerTeva Canada Limited
Normo GastrylSabex Inc
Normocarb 25Dialysis Solutions Inc.
Normocarb 35Dialysis Solutions Inc.
NulytelyPhysicians Total Care, Inc.
Ocl SolutionAbbott Laboratories, Limited
Ohta's Isan Stomach PowderMaizun Calber (Canada) Ltd.
Ohtas Isan AntacidOhta's Isan Co., Ltd
Omeprazole and Sodium BicarbonatePar Pharmaceutical Inc.
Omeprazole/sodium BicarbonatePrasco Laboratories
Ora Rinse LiqThompson Mckay Pharms Ltd.
Pain Relief Fast ReliefSelect Brand
Peg-3350 and ElectrolytesAffordable Pharmaceuticals, LLC
Peg-3350, Sodium Chloride, Sodium Bicarbonate and Potassium ChlorideAffordable Pharmaceuticals, LLC
Peglyte PowderPendopharm Division Of De Pharmascience Inc
Peglyte SolutionPharmascience Inc
Physioneal 40 Glucose 1.36% W/V 13.6mg/ml Clear-flexBaxter Corporation
Physioneal 40 Glucose 1.36% W/V 13.6mg/ml Solution for Peritoneal DialysisBaxter Corporation
Physioneal 40 Glucose 2.27% W/V 22.7 mg/ml Clear-flexBaxter Corporation
Physioneal 40 Glucose 2.27% W/V 22.7 mg/ml, Solution for Peritoneal DialysisBaxter Corporation
Physioneal 40 Glucose 3.86% W/V 38.6 mg/ml Clear-flexBaxter Corporation
Physioneal 40 Glucose 3.86% W/V 38.6mg/ml, Solution for Peritoneal DialysisBaxter Corporation
Picot Plus EffervescentBristol Myers Squibb De Mexico, S. De R.L. De C.V.
Pleo Alkala AntacidSanum Kehlbeck Gmb H & Co. Kg
Polyethylene Glycol 3350 and ElectrolytesMylan Pharmaceuticals Inc.
Polyethylene Glycol 3350, Sodium Chloride, Sodium Bicarbonate and Potassium Chloride - UnflavoredStrides Arcolab Limited
Polyethylene Glycol 3350, Sodium Chloride, Sodium Bicarbonate and Potassium Chloride With Lemon FlavorStrides Arcolab Limited
Polyethylene Glycol 3350, Sodium Chloride, Sodium Bicarbonate and Potassium Chloride With Orange FlavorStrides Arcolab Limited
Polyethylene Glycol-3350 and ElectrolytesNovel Laboratories, Inc.
Polyethylene Glycol-3350 and Electrolytes With Flavor PackNovel Laboratories, Inc.
Polyethylene Glycol-3350, Sodium Chloride, Potassium Chloride and Sodium BicarbonateNovel Laboratories, Inc.
Premier Value Antacid and Pain Relief MedicineChain Drug Consortium, LLC
Prism0calBaxter Corporation
Prism0cal B22k0/0Baxter Corporation
Prismasol 0Baxter Corporation
Prismasol Bgk2/3.5Gambro Renal Products Inc.
Prismasol Bgk4/2.5Gambro Renal Products Inc.
Prismasol Bgk4/3.5Gambro Renal Products Inc.
Prolax - PwsRivex Pharma Inc.
R04940 LiqBdh Inc.
Relief Otc AntacidTummy Company, Inc.
Sal De Uvas PicotBristol Myers Squibb De Mexico, S. De R.L. De C.V.
Saline RefillsCardinal Health 414, Llc
Saline WashTarget Corporation
SinucleanseAscent Consumer Products, Inc.
Sinucleanse Neti-potAscent Consumer Products, Inc.
Sinucleanse SqueezeAscent Consumer Products, Inc.
Sinus WashCVS Pharmacy
Soda Mint TabStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Sodium Bicarbonate-chloride Dry ConcentrateGenpharm Ulc
Sodium Bicarbonate-chloride Dry Concentrate R04955Genpharm Ulc
Sodium Bicarbonate-chloride Liquid Concentrate Ro4941Genpharm Ulc
Solution CardaLaboratoire Atlas Inc
Stomachin AntacidChang Kuo Chou Pharmaceutical Co. Ltd.
Thunas BilexThuna Herbal Remedies Ltd.
Trilyte With Flavor PacksWallace Pharmaceuticals Inc.
Unik Zoru PwrTherapex Division De E Z Em Canada Inc
Unik Zoru TabTherapex Division De E Z Em Canada Inc
Urasal GranulesAxxess Pharma Inc.
Vida Mia Pain ReliefNavarro Discount Pharmacies, LLC
Well At WalgreensWalgreen Company
Winco Foods Effervescent Antacid and Pain ReliefWin Co Foods, Llc
Woodward's Gripe Water LiqW Woodwards C/O Lrc International
Zee-seltzer Antacid and Pain RelieverZEE MEDICAL
ZegeridPhysicians Total Care, Inc.
Zegerid OtcBayer Health Care Llc
SaltsNot Available
Categories
UNII8MDF5V39QO
CAS number144-55-8
WeightAverage: 84.0066
Monoisotopic: 83.982338573
Chemical FormulaCHNaO3
InChI KeyInChIKey=UIIMBOGNXHQVGW-UHFFFAOYSA-M
InChI
InChI=1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1
IUPAC Name
sodium hydrogen carbonate
SMILES
[Na+].OC([O-])=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as organic carbonic acids and derivatives. These are compounds comprising the organic carbonic acid or a derivative thereof.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassOrganic carbonic acids and derivatives
Sub ClassNot Available
Direct ParentOrganic carbonic acids and derivatives
Alternative Parents
Substituents
  • Carbonic acid derivative
  • Monocarboxylic acid or derivatives
  • Hydrocarbon derivative
  • Organic alkali metal salt
  • Organic sodium salt
  • Organic salt
  • Organooxygen compound
  • Organic zwitterion
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Pharmacology
IndicationSodium bicarbonate is used for the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Also is indicated in severe diarrhea which is often accompanied by a significant loss of bicarbonate. Further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturateprotein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of blood pigments.
PharmacodynamicsIntravenous sodium bicarbonate therapy increases plasma bicarbonate, buffers excess hydrogen ion concentration, raises blood pH and reverses the clinical manifestations of acidosis.
Mechanism of actionSodium bicarbonate is a systemic alkalizer, which increases plasma bicarbonate, buffers excess hydrogen ion concentration, and raises blood pH, thereby reversing the clinical manifestations of acidosis. It is also a urinary alkalizer, increasing the excretion of free bicarbonate ions in the urine, thus effectively raising the urinary pH. By maintaining an alkaline urine, the actual dissolution of uric acid stones may be accomplished. Sodium bicarbonate acts as an antacid and reacts chemically to neutralize or buffer existing quantities of stomach acid but has no direct effect on its output. This action results in increased pH value of stomach contents, thus providing relief of hyperacidity symptoms. [PharmGKB]
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9292
Blood Brain Barrier+0.936
Caco-2 permeable-0.5321
P-glycoprotein substrateNon-substrate0.8785
P-glycoprotein inhibitor INon-inhibitor0.9903
P-glycoprotein inhibitor IINon-inhibitor0.9931
Renal organic cation transporterNon-inhibitor0.9563
CYP450 2C9 substrateNon-substrate0.8326
CYP450 2D6 substrateNon-substrate0.9017
CYP450 3A4 substrateNon-substrate0.8144
CYP450 1A2 substrateNon-inhibitor0.9053
CYP450 2C9 inhibitorNon-inhibitor0.9337
CYP450 2D6 inhibitorNon-inhibitor0.9401
CYP450 2C19 inhibitorNon-inhibitor0.9461
CYP450 3A4 inhibitorNon-inhibitor0.9774
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9911
Ames testNon AMES toxic0.9285
CarcinogenicityNon-carcinogens0.5181
BiodegradationReady biodegradable0.9636
Rat acute toxicity1.9204 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9596
hERG inhibition (predictor II)Non-inhibitor0.9866
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Liquidtopical50 mg/mL
Liquidtopical5 g/100g
Tablet (effervescent)oral
Tablet, effervescentoral
Powder for solutionintraocular
Powder, for solutionoral1 g/g
Powderoral100 %
Powder for solutiondialysis
Tablet (delayed-release); kit; powder for solutionoral
Liquid81.25 g
Liquid
Liquid72 g
Liquiddialysis80.68 g
Solutiondialysis80.7 g
Solutiondialysis
Solutiondialysis81.3 g
Liquiddialysis
Powderdialysis1250 g
Powderdialysis650 g
Powderdialysis720 g
Kit; powder for solutiondialysis
Powder for solutiondialysis900 g
Granule, effervescentoral
Granule, effervescentoral1.02 g/5g
Powder (effervescent)oral1.8 g
Powder (effervescent)oral269 mg
Granulesoral
Solution; kitintraocular
Suppositoryrectal
Powder (effervescent)oral
Powder for solutionnasogastric; oral
Powder, for solutionnasogastric
Kit
Powdernasal
Solutionnasal
Liquidoral525 mg/15mL
Powderoral2.6 g/2.6g
Liquidoral25 mg/mL
Powdertopical165 g/300g
Powderdialysis6 kg
Powder for solutiondialysis650 g
Powderoral1000 mg/g
Granuleoral
Powder for solutionoral
Liquiddialysis81.25 g
Solution; kitintraocular; irrigation
Injectionintravenous.2 g/5mL
Injection, solutionintravenous.2 g/5mL
Solutionoral
Powder
Liquid; mouthwash/garglerefer (see dosage form)
Solutionintravenous; dialysis
Solutionintravenous
Liquidoral
Tabletoral
Injectionintravenous.9 meq/mL
Injectionintravenous84 mg/mL
Injectionparenteral84 mg/mL
Injection, solutionintravenous1 meq/mL
Injection, solutionintravenous42 mg/mL
Injection, solutionintravenous44.6 meq/50mL
Injection, solutionintravenous75 mg/mL
Injection, solutionintravenous84 mg/mL
Powderoral; topical100 %
Solutionintravenous42 mg/mL
Solutionparenteral84 mg/mL
Tablet, orally disintegratingoral650 mg/1
Liquidintravenous50 mg
Solutionintravenous5 g
Tabletoral325 mg/1
Tabletoral650 mg/1
Powder for solutiondialysis672 g
Liquidintravenous42 mg
Solutionintravenous42 mg
Liquidintravenous75 mg
Solutionintravenous75 mg
Liquidintravenous84 mg
Solutionintravenous84 mg
Tabletoral300 mg
Tabletoral600 mg
Powderdialysis
Powder for solutiondialysis1100 g
Powder for solutiondialysis760 g
Capsuleoral
Powderoral
Creamtopical50 mg/g
Powder, for solutionnasogastric; oral
Powder (effervescent)
Powder for solutiondialysis750 g
Kitnasal
Powder, for solutionnasal
Powder, for solutionoral
Powder, for suspensionoral
Prices
Unit descriptionCostUnit
Golytely 236 gm Solution28.0USD bottle
Colyte 240 gm Solution26.0USD bottle
Golytely 227.1 gm Solution Packet21.85USD packet
Colyte-Flavored 240 gm Solution18.17USD bottle
Elliotts b solution ampule4.71USD ml
Sodium bicarb 4.2% vial1.45USD ml
Neut 4% vial0.92USD ml
Bss plus eye solution0.2USD ml
Sodium bicarb 650 mg tablet0.07USD tablet
Antacid 650 mg tablet0.05USD tablet
Antacid 325 mg tablet0.04USD tablet
Sodium bicarb 325 mg tablet0.04USD tablet
Sodium bicarb 7.5% vial0.04USD ml
Sodium bicarbonate powder0.03USD g
Sodium bicarb 8.4% vial0.02USD ml
Sodium bicarbonate 5% inj0.02USD ml
Colyte with flavor packets0.01USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5840737 No1996-07-152016-07-15Us
US5945449 No1997-10-312017-10-31Us
US6489346 No1996-07-162016-07-16Us
US6645988 No1996-07-162016-07-16Us
US6699885 No1996-07-162016-07-16Us
US6780882 No1996-07-152016-07-15Us
US7084130 No2001-11-292021-11-29Us
US7291324 No2002-10-222022-10-22Us
US7300674 No2003-03-042023-03-04Us
US7399772 No1996-07-152016-07-15Us
USRE45198 No1996-07-162016-07-16Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting pointDecomposes around 50 °CNot Available
water solubility1E+005 mg/L (at 25 °C)MERCK INDEX (1996)
pKa6.3Not Available
Predicted Properties
PropertyValueSource
Water Solubility764.0 mg/mLALOGPS
logP-0.06ALOGPS
logP0.25ChemAxon
logS0.96ALOGPS
pKa (Strongest Acidic)6.05ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area60.36 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity20.34 m3·mol-1ChemAxon
Polarizability3.86 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

Alan B. Gancy, Rustom P. Poncha, “Production of low bulk density product from sodium bicarbonate by the use of an inert gas stream.” U.S. Patent US3984527, issued August, 1922.

US3984527
General ReferencesNot Available
External Links
ATC CodesB05CB04B05XA02
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (74 KB)
Interactions
Drug Interactions
Drug
AcepromazineSodium bicarbonate can cause a decrease in the absorption of Acepromazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Sodium bicarbonate.
AmphetamineThe serum concentration of Amphetamine can be increased when it is combined with Sodium bicarbonate.
AtazanavirSodium bicarbonate can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
BisacodylThe therapeutic efficacy of Bisacodyl can be decreased when used in combination with Sodium bicarbonate.
Bismuth SubcitrateThe therapeutic efficacy of Bismuth Subcitrate can be decreased when used in combination with Sodium bicarbonate.
BosutinibThe serum concentration of Bosutinib can be decreased when it is combined with Sodium bicarbonate.
BudesonideThe bioavailability of Budesonide can be decreased when combined with Sodium bicarbonate.
CaptoprilThe serum concentration of Captopril can be decreased when it is combined with Sodium bicarbonate.
CathinoneSodium bicarbonate may decrease the excretion rate of Cathinone which could result in a lower serum level and potentially a reduction in efficacy.
CefditorenThe serum concentration of Cefditoren can be decreased when it is combined with Sodium bicarbonate.
CefpodoximeThe serum concentration of Cefpodoxime can be decreased when it is combined with Sodium bicarbonate.
CefuroximeThe serum concentration of Cefuroxime can be decreased when it is combined with Sodium bicarbonate.
ChloroquineThe serum concentration of Chloroquine can be decreased when it is combined with Sodium bicarbonate.
CysteamineThe therapeutic efficacy of Cysteamine can be decreased when used in combination with Sodium bicarbonate.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be decreased when it is combined with Sodium bicarbonate.
DabrafenibThe serum concentration of Dabrafenib can be decreased when it is combined with Sodium bicarbonate.
DasatinibSodium bicarbonate can cause a decrease in the absorption of Dasatinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Sodium bicarbonate.
DexmethylphenidateSodium bicarbonate can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.
ElvitegravirThe serum concentration of Elvitegravir can be decreased when it is combined with Sodium bicarbonate.
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Sodium bicarbonate.
FlecainideSodium bicarbonate may decrease the arrhythmogenic activities of Flecainide.
FosinoprilThe serum concentration of Fosinopril can be decreased when it is combined with Sodium bicarbonate.
GabapentinThe serum concentration of Gabapentin can be decreased when it is combined with Sodium bicarbonate.
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Sodium bicarbonate.
HexamethylenetetramineThe therapeutic efficacy of Hexamethylenetetramine can be decreased when used in combination with Sodium bicarbonate.
HyoscyamineThe serum concentration of Hyoscyamine can be decreased when it is combined with Sodium bicarbonate.
Iron DextranSodium bicarbonate can cause a decrease in the absorption of Iron Dextran resulting in a reduced serum concentration and potentially a decrease in efficacy.
IsoniazidSodium bicarbonate can cause a decrease in the absorption of Isoniazid resulting in a reduced serum concentration and potentially a decrease in efficacy.
ItraconazoleThe serum concentration of Itraconazole can be decreased when it is combined with Sodium bicarbonate.
KetoconazoleThe serum concentration of Ketoconazole can be decreased when it is combined with Sodium bicarbonate.
LedipasvirThe serum concentration of Ledipasvir can be decreased when it is combined with Sodium bicarbonate.
LithiumSodium bicarbonate may increase the excretion rate of Lithium which could result in a higher serum level.
MecamylamineThe serum concentration of Mecamylamine can be increased when it is combined with Sodium bicarbonate.
MemantineThe serum concentration of Memantine can be increased when it is combined with Sodium bicarbonate.
MesalazineThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Sodium bicarbonate.
MethylphenidateSodium bicarbonate can cause an increase in the absorption of Methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.
NilotinibThe serum concentration of Nilotinib can be decreased when it is combined with Sodium bicarbonate.
OxytetracyclineSodium bicarbonate can cause a decrease in the absorption of Oxytetracycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
PazopanibThe serum concentration of Pazopanib can be decreased when it is combined with Sodium bicarbonate.
PenicillamineThe serum concentration of Penicillamine can be decreased when it is combined with Sodium bicarbonate.
Polystyrene sulfonateThe risk or severity of adverse effects can be increased when Sodium bicarbonate is combined with Polystyrene sulfonate.
PravastatinThe serum concentration of Pravastatin can be decreased when it is combined with Sodium bicarbonate.
QuinidineSodium bicarbonate may decrease the excretion rate of Quinidine which could result in a lower serum level and potentially a reduction in efficacy.
QuinineThe serum concentration of Quinine can be increased when it is combined with Sodium bicarbonate.
RilpivirineThe serum concentration of Rilpivirine can be decreased when it is combined with Sodium bicarbonate.
RiociguatThe serum concentration of Riociguat can be decreased when it is combined with Sodium bicarbonate.
SotalolThe serum concentration of Sotalol can be decreased when it is combined with Sodium bicarbonate.
SulpirideThe serum concentration of Sulpiride can be decreased when it is combined with Sodium bicarbonate.
TriethylenetetramineSodium bicarbonate can cause a decrease in the absorption of Triethylenetetramine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Food InteractionsNot Available

Targets

1. Hydrogen ions
Kind
Small molecule
Organism
Pharmacological action
yes
Actions
neutralizer
References
  1. Nudel DB, Peterson BJ, Buckley BJ, Kaplan NA, Weinhaouse E, Gootman N: Comparative effects of bicarbonate and dichloroacetate in newborn swine with hypoxic lactic acidosis. Dev Pharmacol Ther. 1990;15(2):86-93. [PubMed:1964114 ]
  2. Roderick P, Willis NS, Blakeley S, Jones C, Tomson C: Correction of chronic metabolic acidosis for chronic kidney disease patients. Cochrane Database Syst Rev. 2007 Jan 24;(1):CD001890. [PubMed:17253467 ]
  3. Balali-Mood M, Balali-Mood K: Neurotoxic disorders of organophosphorus compounds and their managements. Arch Iran Med. 2008 Jan;11(1):65-89. [PubMed:18154426 ]
  4. Vaughan-Jones RD, Spitzer KW: Role of bicarbonate in the regulation of intracellular pH in the mammalian ventricular myocyte. Biochem Cell Biol. 2002;80(5):579-96. [PubMed:12440699 ]
  5. Levraut J, Giunti C, Ciebiera JP, de Sousa G, Ramhani R, Payan P, Grimaud D: Initial effect of sodium bicarbonate on intracellular pH depends on the extracellular nonbicarbonate buffering capacity. Crit Care Med. 2001 May;29(5):1033-9. [PubMed:11378618 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Sodium:bicarbonate symporter activity
Specific Function:
Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.Isoform 2: May have a higher activity than isoform 1.
Gene Name:
SLC4A4
Uniprot ID:
Q9Y6R1
Molecular Weight:
121459.38 Da
References
  1. Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. [PubMed:17071329 ]
  2. Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. [PubMed:15014910 ]
  3. Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Minerva Urol Nefrol. 2003 Jun;55(2):131-40. [PubMed:12847417 ]
  4. Soleimani M: Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. J Nephrol. 2002 Mar-Apr;15 Suppl 5:S32-40. [PubMed:12027220 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Sodium:bicarbonate symporter activity
Specific Function:
Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity.
Gene Name:
SLC4A7
Uniprot ID:
Q9Y6M7
Molecular Weight:
136042.595 Da
References
  1. Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. [PubMed:17071329 ]
  2. Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. [PubMed:15014910 ]
  3. Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Minerva Urol Nefrol. 2003 Jun;55(2):131-40. [PubMed:12847417 ]
  4. Soleimani M: Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. J Nephrol. 2002 Mar-Apr;15 Suppl 5:S32-40. [PubMed:12027220 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Sodium:bicarbonate symporter activity
Specific Function:
Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediate...
Gene Name:
SLC4A8
Uniprot ID:
Q2Y0W8
Molecular Weight:
122936.66 Da
References
  1. Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. [PubMed:17071329 ]
  2. Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. [PubMed:15014910 ]
  3. Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Minerva Urol Nefrol. 2003 Jun;55(2):131-40. [PubMed:12847417 ]
  4. Soleimani M: Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. J Nephrol. 2002 Mar-Apr;15 Suppl 5:S32-40. [PubMed:12027220 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Sodium:bicarbonate symporter activity
Specific Function:
Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alteration...
Gene Name:
SLC4A5
Uniprot ID:
Q9BY07
Molecular Weight:
126254.04 Da
References
  1. Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. [PubMed:17071329 ]
  2. Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. [PubMed:15014910 ]
  3. Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Minerva Urol Nefrol. 2003 Jun;55(2):131-40. [PubMed:12847417 ]
  4. Soleimani M: Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. J Nephrol. 2002 Mar-Apr;15 Suppl 5:S32-40. [PubMed:12027220 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Sodium:bicarbonate symporter activity
Specific Function:
Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity).
Gene Name:
SLC4A10
Uniprot ID:
Q6U841
Molecular Weight:
125945.115 Da
References
  1. Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. [PubMed:17071329 ]
  2. Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. [PubMed:15014910 ]
  3. Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Minerva Urol Nefrol. 2003 Jun;55(2):131-40. [PubMed:12847417 ]
  4. Soleimani M: Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. J Nephrol. 2002 Mar-Apr;15 Suppl 5:S32-40. [PubMed:12027220 ]
Comments
comments powered by Disqus
Drug created on July 08, 2007 10:59 / Updated on May 30, 2016 02:08