19-Norandrostenedione refers to two steroid isomers that were once marketed as dietary supplements and mainly used by body builders. After 2005, 19-Norandrostenedione was regulated in the United States as a schedule III controlled substance, as well as banned from use in competitive sports by the World Anti-Doping Agency.
In the body 19-norandrostenedione is rapidly metabolized into nandrolone, also known as nortestosterone.
|Brand mixtures||Not Available|
|Mass Spec||Not Available|
|Class||Steroids and Steroid Derivatives|
|Alternative parents||Estrogens and Derivatives; Ketones; Polyamines|
|Substituents||ketone; polyamine; carbonyl group|
|Classification description||This compound belongs to the ketosteroids. These are steroid derivatives comprising a ketone group attached to steroid skeleton.|
|Indication||The claim that supplemental 19-norandrostenedione has anabolic effects is unsubstantiated.|
|Mechanism of action||19-Norandrostenedione may be metabolized to 19-nortestosterone in both men and women. 19-Norandrostenedione, also known as nandrolone, is the basic substance of some very popular injectable anabolic steroids, however 19-norandrostenedione is not metabolized to testosterone. Whether or not increases in 19-nortestosterone levels would be sustained long enough by taking 19-norandrostenedione to show an increase in nitrogen retention and muscle strength and mass is unknown. 19-Norandrostenedione has also been shown to bind to androgen receptors with high selectivity. Transactivation of androgen receptor dependent reporter gene expression was 10 times lower than that produced by dihydrotestosterone. |
|Absorption||Absorption appears variable, but some absorption does occur.|
|Volume of distribution||Not Available|
|Protein binding||Not Available|
Specific metabolites of 19-nor-5-androstene-3, 17-dione are 19-nordehydroandrosterone and 19-nordehydroepiandrosterone.
|Route of elimination||Not Available|
|Half life||Not Available|
|SNP Mediated Effects||Not Available|
|SNP Mediated Adverse Drug Reactions||Not Available|
|Predicted ADMET features|
|Experimental Properties||Not Available|
|Synthesis Reference||Not Available|
1. Diel, P., et al. “The prohormone 19-norandrostenedione displays selective androgen receptor modulator (SARM) like properties after subcutaneous administration.” Toxicology letters 177.3 (2008): 198-204.
|ATC Codes||Not Available|
|AHFS Codes||Not Available|
|PDB Entries||Not Available|
|FDA label||Not Available|
|Drug Interactions||Not Available|
|Food Interactions||Not Available|