| Version |
2.5 |
| Creation Date |
2007-08-29 18:51:29 |
| Update Date |
2009-02-19 16:04:08 |
| Primary Accession Number |
DB01607 |
| Secondary Accession Number |
Not Available |
| Name |
Ticarcillin |
| Drug Type |
|
| Description |
An antibiotic derived from penicillin similar to carbenicillin in action. |
| Synonyms |
- Ticarcilina [inn-spanish]
- Ticarcillin supplement
- Ticarcilline [inn-french]
- Ticarcillinum [inn-latin]
|
| Brand Names |
Not Available |
| Brand Mixtures |
- Timentin (Ticarcillin + Clavulanate)
|
| Chemical IUPAC Name |
(2S,5R,6R)-6-[[(2R)-3-hydroxy-3-oxo-2-thiophen-3-ylpropanoyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Chemical Formula |
C15H16N2O6S2 |
| Chemical Structure |
 |
| CAS Registry Number |
34787-01-4 |
| InChI Identifier |
InChI=1/C15H16N2O6S2/c1-15(2)9(14(22)23)17-11(19)8(12(17)25-15)16-10(18)7(13(20)21)6-3-4-24-5-6/h3-5,7-9,12H,1-2H3,(H,16,18)(H,20,21)(H,22,23)/t7-,8-,9+,12-/m1/s1/f/h16,20,22H |
| InChI Key |
OHKOGUYZJXTSFX-MRFNKDAEDD |
| KEGG Drug |
Not Available |
| KEGG Compound |
C07139  |
| PubChem Compound |
36921 |
| PubChem Substance |
9348 |
| ChEBI ID |
Not Available |
| PharmGKB ID |
PA451684 |
| HET ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
Not Available |
| RxList Link |
http://www.rxlist.com/cgi/generic/timentin.htm |
| PDRhealth Link |
Not Available |
| Wikipedia Link |
http://en.wikipedia.org/wiki/Ticarcillin |
| FDA Label |
Not Available |
| Material Safety Data Sheet (MSDS) |
Not Available |
| Synthesis Reference |
Not Available |
| Average Molecular Weight |
384.4270 |
| Monoisotopic Molecular Weight |
384.0450 |
| State |
Solid |
| Melting Point |
Not Available |
| Experimental Water Solubility |
Not Available
Source: PhysProp
|
| Predicted Water Solubility |
7.18e-02 mg/mL
Calculated using ALOGPS
|
| Experimental LogP/Hydrophobicity |
Not Available
Source: PhysProp
|
| Predicted LogP |
0.99
Calculated using ALOGPS
|
| Experimental LogS |
Not Available |
| Predicted LogS |
-3.73
Calculated using ALOGPS
|
| Experimental Caco2 Permeability |
Not Available |
| pKa/Isoelectric Point |
Not Available |
| Mass Spectrum |
Not Available
|
| MOL File |
Show | Download |
| SDF File |
Show | Download |
| PDB File |
Show | Download |
| 2D Structure |
|
| 3D Structure |
|
| Experimental PDB ID |
Not Available |
| Isomeric SMILES |
CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](C(O)=O)C3=CSC=C3)C(=O)N2[C@H]1C(O)=O |
| Canonical SMILES |
CC1(C)SC2C(NC(=O)C(C(O)=O)C3=CSC=C3)C(=O)N2C1C(O)=O |
| Drug Category |
- Anti-Bacterial Agents
- Penicillins
|
| ATC Codes |
Not Available |
| AHFS Codes |
Not Available |
| Indication |
For the treatment of bacterial infections. |
| Pharmacology |
Ticarcillin is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria. Ticarcillin is, however, susceptible to degradation by ß-lactamases, and therefore, the spectrum of activity does not normally include organisms which produce these enzymes. |
| Mechanism of Action |
Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis when the bacteria tries to divide, causing death. |
| Absorption |
Not Available |
| Toxicity |
As with other penicillins, neurotoxic reactions may arise when very high doses of ticarcillin are administered, especially in patients with impaired renal function. |
| Protein Binding |
45% |
| Biotransformation |
Not Available |
| Half Life |
1.1 hours |
| Dosage Forms |
Not Available
|
| Patient Information |
Not Available |
| Contraindications |
Not Available |
| Interactions |
Not Available |
| Drug Interactions |
| Drug |
Interaction |
| Amikacin |
Ticarcillin may reduce the serum concentration of Amikacin. Ticarcillin may inactivate Amikacin in vitro and the two agents should not be administered simultaneously through the same IV line. |
| Demeclocycline |
Demeclocycline may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Demeclocycline. |
| Doxycycline |
Doxycycline may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Doxycycline. |
| Fusidic Acid |
Fusidic acid may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Fusidic acid. |
| Gentamicin |
Ticarcillin may reduce the serum concentration of Gentamicin. Ticarcillin may inactivate Gentamicin in vitro and the two agents should not be administered simultaneously through the same IV line. |
| Kanamycin |
Ticarcillin may reduce the serum concentration of Kanamycin. Ticarcillin may inactivate Kanamycin in vitro and the two agents should not be administered simultaneously through the same IV line. |
| Minocycline |
Minocycline may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Minocycline. |
| Neomycin |
Ticarcillin may reduce the serum concentration of Neomycin. Ticarcillin may inactivate Neomycin in vitro and the two agents should not be administered simultaneously through the same IV line. |
| Oxytetracycline |
Oxytetracycline may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Oxytetracycline. |
| Streptomycin |
Ticarcillin may reduce the serum concentration of Streptomycin. Ticarcillin may inactivate Streptomycin in vitro and the two agents should not be administered simultaneously through the same IV line. |
| Tetracycline |
Tetracycline may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Tetracycline. |
| Tobramycin |
Ticarcillin may reduce the serum concentration of Tobramycin. Ticarcillin may inactivate Tobramycin in vitro and the two agents should not be administered simultaneously through the same IV line. |
|
| Food Interactions |
Not Available
|
| Pathways |
Not Available
|
| General References |
- Wikipedia
- RxList
|
| Organisms Affected |
- Enteric bacteria and other eubacteria
|
