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Identification
NameAceprometazine
Accession NumberDB01615
TypeSmall Molecule
GroupsApproved
DescriptionAceprometazine (INN) is a prescription drug with neuroleptic and anti-histamine properties. It is not widely prescribed. It may be used in combination with meprobamate for the treatment of sleep disorders. This combination is available in France under the trade name Mepronizine. [Wikipedia]
Structure
Thumb
Synonyms
10-(2-(Dimethylamino)propyl)phenothiazin-2-yl methyl ketone
Aceprometazina
Aceprometazinum
Acepromethazine
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
MepronizineNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNII984N9YTM4Y
CAS number13461-01-3
WeightAverage: 326.456
Monoisotopic: 326.145284026
Chemical FormulaC19H22N2OS
InChI KeyInChIKey=XLOQNFNTQIRSOX-UHFFFAOYSA-N
InChI
InChI=1S/C19H22N2OS/c1-13(20(3)4)12-21-16-7-5-6-8-18(16)23-19-10-9-15(14(2)22)11-17(19)21/h5-11,13H,12H2,1-4H3
IUPAC Name
1-{10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl}ethan-1-one
SMILES
CC(CN1C2=CC=CC=C2SC2=C1C=C(C=C2)C(C)=O)N(C)C
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenothiazines. These are polycyclic aromatic compounds containing a phenothiazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a para-thiazine ring.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzothiazines
Sub ClassPhenothiazines
Direct ParentPhenothiazines
Alternative Parents
Substituents
  • Phenothiazine
  • Alkyldiarylamine
  • Diarylthioether
  • Acetophenone
  • Aryl alkyl ketone
  • Aryl ketone
  • Benzoyl
  • Benzenoid
  • Para-thiazine
  • Tertiary aliphatic amine
  • Tertiary amine
  • Ketone
  • Azacycle
  • Thioether
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationAceprometazine is often used in combination with meprobamate for the treatment of sleep disorders.
PharmacodynamicsAceprometazine is a drug with neuroleptic and anti-histamine properties. It is not widely prescribed.
Mechanism of actionAceprometazine, acting as an H1-receptor antagonist can induce sedation by being able to cross the blood-brain-barrier and binding to H1-receptors in the central nervous system.
Related Articles
AbsorptionRapidly absorbed following oral administration.
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Hepatic.

Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.992
Blood Brain Barrier+0.9852
Caco-2 permeable+0.8427
P-glycoprotein substrateSubstrate0.8358
P-glycoprotein inhibitor IInhibitor0.9139
P-glycoprotein inhibitor IIInhibitor0.5926
Renal organic cation transporterInhibitor0.5135
CYP450 2C9 substrateNon-substrate0.7768
CYP450 2D6 substrateSubstrate0.8188
CYP450 3A4 substrateSubstrate0.5876
CYP450 1A2 substrateInhibitor0.8793
CYP450 2C9 inhibitorNon-inhibitor0.9009
CYP450 2D6 inhibitorInhibitor0.7954
CYP450 2C19 inhibitorNon-inhibitor0.8674
CYP450 3A4 inhibitorNon-inhibitor0.7954
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.5333
Ames testNon AMES toxic0.8613
CarcinogenicityNon-carcinogens0.8886
BiodegradationNot ready biodegradable0.9941
Rat acute toxicity2.6833 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9729
hERG inhibition (predictor II)Inhibitor0.7319
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.0122 mg/mLALOGPS
logP4.35ALOGPS
logP3.85ChemAxon
logS-4.4ALOGPS
pKa (Strongest Acidic)16.06ChemAxon
pKa (Strongest Basic)8.32ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area23.55 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity98.91 m3·mol-1ChemAxon
Polarizability36.79 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesNot Available
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
Interactions
Drug Interactions
Drug
3,4-MethylenedioxyamphetamineAceprometazine may decrease the stimulatory activities of 3,4-Methylenedioxyamphetamine.
3,4-MethylenedioxymethamphetamineAceprometazine may decrease the stimulatory activities of 3,4-Methylenedioxymethamphetamine.
7-NitroindazoleThe risk or severity of adverse effects can be increased when Aceprometazine is combined with 7-Nitroindazole.
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Aceprometazine.
adipiplonThe risk or severity of adverse effects can be increased when Aceprometazine is combined with adipiplon.
AgomelatineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Agomelatine.
AlfaxaloneThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Alfaxalone.
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Aceprometazine.
AlmotriptanThe risk or severity of adverse effects can be increased when Almotriptan is combined with Aceprometazine.
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Aceprometazine.
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Aceprometazine.
AmisulprideThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Amisulpride.
AmitriptylineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Aceprometazine.
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Aceprometazine.
AmoxapineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Amoxapine.
AmperozideThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Amperozide.
AmphetamineAceprometazine may decrease the stimulatory activities of Amphetamine.
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Aceprometazine.
ArticaineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Articaine.
AsenapineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Asenapine.
AzaperoneThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Azaperone.
AzelastineAceprometazine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Aceprometazine.
BaclofenThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Baclofen.
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Aceprometazine.
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Aceprometazine.
BenzphetamineAceprometazine may decrease the stimulatory activities of Benzphetamine.
Benzyl alcoholThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Benzyl alcohol.
BrexpiprazoleThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Brexpiprazole.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Aceprometazine.
BrimonidineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Brimonidine.
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Aceprometazine.
BromocriptineThe risk or severity of adverse effects can be increased when Bromocriptine is combined with Aceprometazine.
BrompheniramineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Brompheniramine.
BrotizolamThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Brotizolam.
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Aceprometazine.
BuprenorphineThe risk or severity of adverse effects can be increased when Buprenorphine is combined with Aceprometazine.
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Aceprometazine.
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Aceprometazine.
ButacaineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Butacaine.
ButalbitalThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Butalbital.
ButambenThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Butamben.
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Aceprometazine.
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Aceprometazine.
CabergolineThe risk or severity of adverse effects can be increased when Cabergoline is combined with Aceprometazine.
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Aceprometazine.
CarbinoxamineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Carbinoxamine.
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Aceprometazine.
CarisoprodolThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Carisoprodol.
CetirizineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Cetirizine.
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Aceprometazine.
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Aceprometazine.
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Aceprometazine.
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Aceprometazine.
ChlorphenamineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Chlorphenamine.
ChlorphentermineAceprometazine may decrease the stimulatory activities of Chlorphentermine.
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Aceprometazine.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Aceprometazine.
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Chlorzoxazone.
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Aceprometazine.
CitalopramThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Citalopram.
ClemastineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Clemastine.
ClidiniumThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Clidinium.
ClobazamThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Clobazam.
clomethiazoleThe risk or severity of adverse effects can be increased when Aceprometazine is combined with clomethiazole.
ClomipramineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Clomipramine.
ClonazepamThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Clonazepam.
ClonidineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Clonidine.
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Aceprometazine.
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Aceprometazine.
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Aceprometazine.
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Aceprometazine.
CyclizineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Cyclizine.
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Aceprometazine.
CyproheptadineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Cyproheptadine.
DantroleneThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Dantrolene.
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Aceprometazine.
DapoxetineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Dapoxetine.
deramciclaneThe risk or severity of adverse effects can be increased when Aceprometazine is combined with deramciclane.
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Aceprometazine.
DesipramineThe risk or severity of adverse effects can be increased when Desipramine is combined with Aceprometazine.
DesloratadineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Desloratadine.
DesvenlafaxineThe risk or severity of adverse effects can be increased when Desvenlafaxine is combined with Aceprometazine.
DetomidineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Detomidine.
DexbrompheniramineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Dexbrompheniramine.
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Aceprometazine.
DextroamphetamineAceprometazine may decrease the stimulatory activities of Dextroamphetamine.
DextromethorphanThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Aceprometazine.
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Aceprometazine.
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Aceprometazine.
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Aceprometazine.
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Aceprometazine.
DifenoxinThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Difenoxin.
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Aceprometazine.
DihydroergotamineThe risk or severity of adverse effects can be increased when Dihydroergotamine is combined with Aceprometazine.
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Aceprometazine.
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Aceprometazine.
DimenhydrinateThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Dimenhydrinate.
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Aceprometazine.
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Aceprometazine.
DoramectinThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Doramectin.
DoxepinThe risk or severity of adverse effects can be increased when Doxepin is combined with Aceprometazine.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Aceprometazine.
DoxylamineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Doxylamine.
DPDPEThe risk or severity of adverse effects can be increased when Aceprometazine is combined with DPDPE.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Aceprometazine.
DroperidolThe risk or severity of adverse effects can be increased when Droperidol is combined with Aceprometazine.
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Aceprometazine.
DuloxetineThe risk or severity of adverse effects can be increased when Duloxetine is combined with Aceprometazine.
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Aceprometazine.
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Aceprometazine.
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Aceprometazine is combined with ECGONINE METHYL ESTER.
EfavirenzThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Efavirenz.
EletriptanThe risk or severity of adverse effects can be increased when Eletriptan is combined with Aceprometazine.
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Aceprometazine.
EntacaponeThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Entacapone.
Ergoloid mesylateThe risk or severity of adverse effects can be increased when Ergoloid mesylate is combined with Aceprometazine.
ErgonovineThe risk or severity of adverse effects can be increased when Ergonovine is combined with Aceprometazine.
ErgotamineThe risk or severity of adverse effects can be increased when Ergotamine is combined with Aceprometazine.
EscitalopramThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Escitalopram.
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Aceprometazine.
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Aceprometazine.
EthanolAceprometazine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Aceprometazine.
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Aceprometazine.
EthosuximideThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Ethosuximide.
EthotoinThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Ethotoin.
Ethyl carbamateThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Ethyl carbamate.
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Aceprometazine.
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Aceprometazine.
EtidocaineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Etidocaine.
EtifoxineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Etifoxine.
EtizolamThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Etizolam.
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Aceprometazine.
EtoperidoneThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Etoperidone.
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Aceprometazine.
EzogabineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Ezogabine.
FelbamateThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Felbamate.
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Aceprometazine.
FenfluramineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Fenfluramine.
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Aceprometazine.
FexofenadineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Fexofenadine.
FlibanserinThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Flibanserin.
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Aceprometazine.
FlunarizineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Flunarizine.
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Aceprometazine.
FluoxetineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Fluoxetine.
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Aceprometazine.
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Aceprometazine.
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Aceprometazine.
FluspirileneThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Fluspirilene.
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Fluticasone Propionate.
FluvoxamineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Fluvoxamine.
FosphenytoinThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Fosphenytoin.
FospropofolThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Fospropofol.
FrovatriptanThe risk or severity of adverse effects can be increased when Frovatriptan is combined with Aceprometazine.
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Aceprometazine.
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Aceprometazine is combined with gabapentin enacarbil.
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Aceprometazine.
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Aceprometazine.
GuanfacineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Guanfacine.
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Aceprometazine.
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Aceprometazine.
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Aceprometazine.
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Aceprometazine.
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Aceprometazine.
HydrocodoneThe risk or severity of adverse effects can be increased when Hydrocodone is combined with Aceprometazine.
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Aceprometazine.
Hydroxyamphetamine hydrobromideAceprometazine may decrease the stimulatory activities of Hydroxyamphetamine hydrobromide.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Aceprometazine.
HydroxyzineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Hydroxyzine.
IloperidoneThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Iloperidone.
ImipramineThe risk or severity of adverse effects can be increased when Imipramine is combined with Aceprometazine.
IndalpineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Indalpine.
IsocarboxazidThe risk or severity of adverse effects can be increased when Isocarboxazid is combined with Aceprometazine.
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Aceprometazine.
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Aceprometazine.
KetazolamThe risk or severity of adverse effects can be increased when Ketazolam is combined with Aceprometazine.
KetobemidoneThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Ketobemidone.
LamotrigineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Lamotrigine.
LevetiracetamThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Levetiracetam.
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Aceprometazine.
LevocabastineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Levocabastine.
LevocetirizineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Levocetirizine.
LevodopaThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Levodopa.
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Aceprometazine.
LevomilnacipranThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Levomilnacipran.
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Aceprometazine.
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Aceprometazine.
LinezolidThe risk or severity of adverse effects can be increased when Linezolid is combined with Aceprometazine.
LisdexamfetamineAceprometazine may decrease the stimulatory activities of Lisdexamfetamine.
LithiumLithium may increase the neurotoxic activities of Aceprometazine.
LithiumThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Lithium.
LofentanilThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Lofentanil.
LoratadineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Loratadine.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Aceprometazine.
LorcaserinThe risk or severity of adverse effects can be increased when Lorcaserin is combined with Aceprometazine.
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Aceprometazine.
Lu AA21004The risk or severity of adverse effects can be increased when Aceprometazine is combined with Lu AA21004.
LurasidoneThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Lurasidone.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Aceprometazine.
Magnesium SulfateThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Magnesium Sulfate.
MaprotilineThe risk or severity of adverse effects can be increased when Maprotiline is combined with Aceprometazine.
MeclizineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Meclizine.
MedetomidineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Medetomidine.
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Aceprometazine.
MelperoneThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Melperone.
MephentermineAceprometazine may decrease the stimulatory activities of Mephentermine.
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Aceprometazine.
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Aceprometazine.
MequitazineAceprometazine may increase the arrhythmogenic activities of Mequitazine.
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Aceprometazine.
MetaxaloneThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Metaxalone.
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Aceprometazine.
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Aceprometazine.
MethamphetamineAceprometazine may decrease the stimulatory activities of Methamphetamine.
MethapyrileneThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Methapyrilene.
MethaqualoneThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Methaqualone.
MethocarbamolThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Methocarbamol.
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Aceprometazine.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Methotrimeprazine is combined with Aceprometazine.
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Aceprometazine.
MethsuximideThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Methsuximide.
MethylphenidateThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Methylphenidate.
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Aceprometazine.
MetoclopramideThe risk or severity of adverse effects can be increased when Metoclopramide is combined with Aceprometazine.
MetyrosineAceprometazine may increase the sedative activities of Metyrosine.
MetyrosineThe risk or severity of adverse effects can be increased when Metyrosine is combined with Aceprometazine.
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Aceprometazine.
MilnacipranThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Milnacipran.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Aceprometazine.
MirtazapineAceprometazine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MirtazapineThe risk or severity of adverse effects can be increased when Mirtazapine is combined with Aceprometazine.
MoclobemideThe risk or severity of adverse effects can be increased when Moclobemide is combined with Aceprometazine.
MolindoneThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Molindone.
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Aceprometazine.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Aceprometazine.
NabiloneThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Nabilone.
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Aceprometazine.
NaratriptanThe risk or severity of adverse effects can be increased when Naratriptan is combined with Aceprometazine.
NefazodoneThe risk or severity of adverse effects can be increased when Nefazodone is combined with Aceprometazine.
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Aceprometazine.
Nitrous oxideThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Nitrous oxide.
NormethadoneThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Normethadone.
NortriptylineThe risk or severity of adverse effects can be increased when Nortriptyline is combined with Aceprometazine.
OlanzapineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Olanzapine.
OlopatadineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Olopatadine.
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Aceprometazine.
OpiumThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Opium.
OrphenadrineAceprometazine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OrphenadrineThe risk or severity of adverse effects can be increased when Orphenadrine is combined with Aceprometazine.
OsanetantThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Osanetant.
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Aceprometazine.
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Aceprometazine.
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Aceprometazine.
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Aceprometazine.
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Aceprometazine.
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Aceprometazine.
ParaldehydeAceprometazine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParaldehydeThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Aceprometazine.
ParoxetineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Paroxetine.
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Aceprometazine.
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Aceprometazine.
PerampanelThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Perampanel.
PerospironeThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Perospirone.
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Aceprometazine.
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Aceprometazine.
PhenelzineThe risk or severity of adverse effects can be increased when Phenelzine is combined with Aceprometazine.
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Aceprometazine.
PhenoxyethanolThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Phenoxyethanol.
PhentermineAceprometazine may decrease the stimulatory activities of Phentermine.
PhenytoinThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Phenytoin.
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Aceprometazine.
PipamperoneThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Pipamperone.
PipotiazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Pipotiazine.
PizotifenThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Pizotifen.
PomalidomideThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Pomalidomide.
PramipexoleAceprometazine may increase the sedative activities of Pramipexole.
PramocaineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Pramocaine.
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with Aceprometazine.
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Aceprometazine.
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Aceprometazine.
PrimidoneThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Primidone.
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Aceprometazine.
ProcarbazineThe risk or severity of adverse effects can be increased when Procarbazine is combined with Aceprometazine.
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Aceprometazine.
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Aceprometazine.
PromethazineThe risk or severity of adverse effects can be increased when Promethazine is combined with Aceprometazine.
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Aceprometazine.
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Aceprometazine.
PropoxycaineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Propoxycaine.
ProtriptylineThe risk or severity of adverse effects can be increased when Protriptyline is combined with Aceprometazine.
PSD502The risk or severity of adverse effects can be increased when Aceprometazine is combined with PSD502.
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Aceprometazine.
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Aceprometazine.
QuinagolideThe therapeutic efficacy of Quinagolide can be decreased when used in combination with Aceprometazine.
RamelteonThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Ramelteon.
RasagilineThe risk or severity of adverse effects can be increased when Rasagiline is combined with Aceprometazine.
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Aceprometazine.
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Aceprometazine.
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Aceprometazine.
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Aceprometazine.
RizatriptanThe risk or severity of adverse effects can be increased when Rizatriptan is combined with Aceprometazine.
RomifidineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Romifidine.
RopiniroleAceprometazine may increase the sedative activities of Ropinirole.
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Aceprometazine.
RotigotineAceprometazine may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Aceprometazine.
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Aceprometazine is combined with S-Ethylisothiourea.
ScopolamineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Scopolamine.
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Aceprometazine.
SelegilineThe risk or severity of adverse effects can be increased when Selegiline is combined with Aceprometazine.
SertindoleThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Sertindole.
SertralineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Sertraline.
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Aceprometazine.
Sodium oxybateThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Sodium oxybate.
StiripentolThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Stiripentol.
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Aceprometazine.
SulpirideThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Sulpiride.
SumatriptanThe risk or severity of adverse effects can be increased when Sumatriptan is combined with Aceprometazine.
SuvorexantThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Suvorexant.
TapentadolThe risk or severity of adverse effects can be increased when Tapentadol is combined with Aceprometazine.
TasimelteonThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Tasimelteon.
Tedizolid PhosphateThe risk or severity of adverse effects can be increased when Tedizolid Phosphate is combined with Aceprometazine.
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Aceprometazine.
TetrabenazineThe risk or severity of adverse effects can be increased when Tetrabenazine is combined with Aceprometazine.
TetracaineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Tetracaine.
TetrodotoxinThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Tetrodotoxin.
ThalidomideAceprometazine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Aceprometazine.
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Aceprometazine.
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Aceprometazine.
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Aceprometazine.
ThiothixeneThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Thiothixene.
TiagabineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Tiagabine.
TiletamineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Tiletamine.
TizanidineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Tizanidine.
TolcaponeThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Tolcapone.
TopiramateThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Topiramate.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Aceprometazine.
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Trans-2-Phenylcyclopropylamine.
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Aceprometazine.
TrazodoneThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Trazodone.
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Aceprometazine.
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Aceprometazine.
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Aceprometazine.
TrimipramineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Aceprometazine.
TriprolidineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Triprolidine.
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Aceprometazine.
VenlafaxineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Aceprometazine.
VigabatrinThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Vigabatrin.
VilazodoneThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Vilazodone.
VortioxetineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Vortioxetine.
XylazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Xylazine.
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Aceprometazine.
ZiconotideThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Ziconotide.
ZimelidineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Zimelidine.
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Aceprometazine.
ZolazepamThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Zolazepam.
ZolmitriptanThe risk or severity of adverse effects can be increased when Zolmitriptan is combined with Aceprometazine.
ZolpidemThe risk or severity of adverse effects can be increased when Zolpidem is combined with Aceprometazine.
ZonisamideThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Zonisamide.
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Aceprometazine.
ZotepineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Zotepine.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Zuclopenthixol.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Histamine receptor activity
Specific Function:
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Gene Name:
HRH1
Uniprot ID:
P35367
Molecular Weight:
55783.61 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Mercier J, Dessaigne S, Menguy A, Manez J: Electro-encephalographic study on the action of the combination meprobamate-aceprometazine on various cerebral systems. Arzneimittelforschung. 1974 Feb;24(2):163-6. [PubMed:4406367 ]
  4. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
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Drug created on August 29, 2007 14:13 / Updated on August 17, 2016 12:23