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Identification
NameHirulog
Accession NumberDB02351  (EXPT03302)
TypeSmall Molecule
GroupsExperimental
DescriptionNot Available
Structure
Thumb
SynonymsNot Available
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNIINot Available
CAS number128270-60-0
WeightAverage: 2180.2853
Monoisotopic: 2178.985813062
Chemical FormulaC98H138N24O33
InChI KeyInChIKey=OIRCOABEOLEUMC-GEJPAHFPSA-N
InChI
InChI=1S/C98H138N24O33/c1-5-52(4)82(96(153)122-39-15-23-70(122)92(149)114-60(30-34-79(134)135)85(142)111-59(29-33-78(132)133)86(143)116-64(43-55-24-26-56(123)27-25-55)89(146)118-67(97(154)155)40-51(2)3)119-87(144)61(31-35-80(136)137)112-84(141)58(28-32-77(130)131)113-88(145)63(42-54-18-10-7-11-19-54)117-90(147)66(45-81(138)139)110-76(129)50-107-83(140)65(44-71(100)124)109-75(128)49-106-73(126)47-104-72(125)46-105-74(127)48-108-91(148)68-21-13-38-121(68)95(152)62(20-12-36-103-98(101)102)115-93(150)69-22-14-37-120(69)94(151)57(99)41-53-16-8-6-9-17-53/h6-11,16-19,24-27,51-52,57-70,82,123H,5,12-15,20-23,28-50,99H2,1-4H3,(H2,100,124)(H,104,125)(H,105,127)(H,106,126)(H,107,140)(H,108,148)(H,109,128)(H,110,129)(H,111,142)(H,112,141)(H,113,145)(H,114,149)(H,115,150)(H,116,143)(H,117,147)(H,118,146)(H,119,144)(H,130,131)(H,132,133)(H,134,135)(H,136,137)(H,138,139)(H,154,155)(H4,101,102,103)/t52-,57+,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,82-/m0/s1
IUPAC Name
(4S)-4-[(2S)-2-[(2S)-2-[(2S)-2-{2-[(2S)-2-(2-{2-[2-(2-{[(2S)-1-[(2S)-2-{[(2S)-1-[(2R)-2-amino-3-phenylpropanoyl]pyrrolidin-2-yl]formamido}-5-carbamimidamidopentanoyl]pyrrolidin-2-yl]formamido}acetamido)acetamido]acetamido}acetamido)-3-carbamoylpropanamido]acetamido}-3-carboxypropanamido]-3-phenylpropanamido]-4-carboxybutanamido]-4-{[(2S,3S)-1-[(2S)-2-{[(1S)-3-carboxy-1-{[(1S)-3-carboxy-1-{[(1S)-1-{[(1S)-1-carboxy-3-methylbutyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}propyl]carbamoyl}propyl]carbamoyl}pyrrolidin-1-yl]-3-methyl-1-oxopentan-2-yl]carbamoyl}butanoic acid
SMILES
CC[[email protected]](C)[[email protected]](NC(=O)[[email protected]](CCC(O)=O)NC(=O)[[email protected]](CCC(O)=O)NC(=O)[[email protected]](CC1=CC=CC=C1)NC(=O)[[email protected]](CC(O)=O)NC(=O)CNC(=O)[[email protected]](CC(N)=O)NC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[[email protected]](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[[email protected]](N)CC1=CC=CC=C1)C(=O)N1CCC[[email protected]]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(O)=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as polypeptides. These are peptides containing ten or more amino acid residues.
KingdomOrganic compounds
Super ClassOrganic Polymers
ClassPolypeptides
Sub ClassNot Available
Direct ParentPolypeptides
Alternative Parents
Substituents
  • Polypeptide
  • Alpha peptide
  • Hexacarboxylic acid or derivatives
  • N-acyl-aliphatic-alpha amino acid
  • N-acyl-alpha amino acid or derivatives
  • N-acyl-alpha-amino acid
  • Alpha-amino acid amide
  • N-acyl-l-alpha-amino acid
  • Phenylpropylamine
  • Amphetamine or derivatives
  • Alpha-amino acid or derivatives
  • N-substituted-alpha-amino acid
  • Pyrrolidine-2-carboxamide
  • Pyrrolidine carboxylic acid or derivatives
  • N-acylpyrrolidine
  • Aralkylamine
  • Phenol
  • Amino fatty acid
  • Fatty acyl
  • Benzenoid
  • N-acyl-amine
  • Fatty amide
  • Monocyclic benzene moiety
  • Tertiary carboxylic acid amide
  • Pyrrolidine
  • Tertiary amine
  • Secondary carboxylic acid amide
  • Primary carboxylic acid amide
  • Guanidine
  • Carboxamide group
  • Azacycle
  • Organoheterocyclic compound
  • Carboximidamide
  • Carboxylic acid
  • Carboxylic acid derivative
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Primary aliphatic amine
  • Imine
  • Carbonyl group
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationNot Available
PharmacodynamicsNot Available
Mechanism of actionNot Available
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.8811
Blood Brain Barrier-0.996
Caco-2 permeable-0.8319
P-glycoprotein substrateSubstrate0.8692
P-glycoprotein inhibitor INon-inhibitor0.647
P-glycoprotein inhibitor IINon-inhibitor0.7858
Renal organic cation transporterNon-inhibitor0.7959
CYP450 2C9 substrateNon-substrate0.7558
CYP450 2D6 substrateNon-substrate0.7957
CYP450 3A4 substrateSubstrate0.5794
CYP450 1A2 substrateNon-inhibitor0.8977
CYP450 2C9 inhibitorNon-inhibitor0.8331
CYP450 2D6 inhibitorNon-inhibitor0.8894
CYP450 2C19 inhibitorNon-inhibitor0.7784
CYP450 3A4 inhibitorNon-inhibitor0.744
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9357
Ames testNon AMES toxic0.7642
CarcinogenicityNon-carcinogens0.8217
BiodegradationNot ready biodegradable0.9705
Rat acute toxicity3.1654 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9307
hERG inhibition (predictor II)Non-inhibitor0.514
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.0464 mg/mLALOGPS
logP-0.76ALOGPS
logP-14ChemAxon
logS-4.7ALOGPS
pKa (Strongest Acidic)2.79ChemAxon
pKa (Strongest Basic)11.88ChemAxon
Physiological Charge-4ChemAxon
Hydrogen Acceptor Count37ChemAxon
Hydrogen Donor Count28ChemAxon
Polar Surface Area901.57 Å2ChemAxon
Rotatable Bond Count66ChemAxon
Refractivity543.33 m3·mol-1ChemAxon
Polarizability215.46 Å3ChemAxon
Number of Rings6ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesNot Available
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
Interactions
Drug Interactions
Drug
AbacavirThe serum concentration of Abacavir can be decreased when it is combined with Hirulog.
AbciximabAbciximab may increase the anticoagulant activities of Hirulog.
AceclofenacAceclofenac may increase the anticoagulant activities of Hirulog.
AcenocoumarolAcenocoumarol may increase the anticoagulant activities of Hirulog.
Acetylsalicylic acidAcetylsalicylic acid may increase the anticoagulant activities of Hirulog.
AdapaleneAdapalene may increase the anticoagulant activities of Hirulog.
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Hirulog.
AllylestrenolThe therapeutic efficacy of Hirulog can be decreased when used in combination with Allylestrenol.
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Hirulog.
AlprostadilAlprostadil may increase the anticoagulant activities of Hirulog.
AlteplaseAlteplase may increase the anticoagulant activities of Hirulog.
AltrenogestThe therapeutic efficacy of Hirulog can be decreased when used in combination with Altrenogest.
ALX-0081ALX-0081 may increase the anticoagulant activities of Hirulog.
AmineptineThe serum concentration of Amineptine can be increased when it is combined with Hirulog.
AminophyllineThe serum concentration of Aminophylline can be decreased when it is combined with Hirulog.
Aminosalicylic AcidAminosalicylic Acid may increase the anticoagulant activities of Hirulog.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Hirulog.
AnagrelideAnagrelide may increase the anticoagulant activities of Hirulog.
AncrodHirulog may increase the anticoagulant activities of Ancrod.
AnistreplaseAnistreplase may increase the anticoagulant activities of Hirulog.
AntipyrineAntipyrine may increase the anticoagulant activities of Hirulog.
Antithrombin III humanHirulog may increase the anticoagulant activities of Antithrombin III human.
ApixabanApixaban may increase the anticoagulant activities of Hirulog.
ApremilastApremilast may increase the anticoagulant activities of Hirulog.
ArdeparinArdeparin may increase the anticoagulant activities of Hirulog.
ArgatrobanArgatroban may increase the anticoagulant activities of Hirulog.
AstaxanthinAstaxanthin may increase the anticoagulant activities of Hirulog.
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Hirulog.
AzapropazoneAzapropazone may increase the anticoagulant activities of Hirulog.
AzelastineAzelastine may increase the anticoagulant activities of Hirulog.
BalsalazideBalsalazide may increase the anticoagulant activities of Hirulog.
BatroxobinBatroxobin may increase the anticoagulant activities of Hirulog.
BazedoxifeneBazedoxifene may decrease the anticoagulant activities of Hirulog.
BecaplerminBecaplermin may increase the anticoagulant activities of Hirulog.
BemiparinBemiparin may increase the anticoagulant activities of Hirulog.
BenoxaprofenBenoxaprofen may increase the anticoagulant activities of Hirulog.
BeraprostBeraprost may increase the anticoagulant activities of Hirulog.
BivalirudinBivalirudin may increase the anticoagulant activities of Hirulog.
BoceprevirThe serum concentration of Hirulog can be decreased when it is combined with Boceprevir.
BromfenacBromfenac may increase the anticoagulant activities of Hirulog.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Hirulog.
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Hirulog.
CangrelorCangrelor may increase the anticoagulant activities of Hirulog.
CarbamazepineThe metabolism of Hirulog can be increased when combined with Carbamazepine.
CarprofenCarprofen may increase the anticoagulant activities of Hirulog.
CastanospermineCastanospermine may increase the anticoagulant activities of Hirulog.
CelecoxibCelecoxib may increase the anticoagulant activities of Hirulog.
CertoparinHirulog may increase the anticoagulant activities of Certoparin.
ChloroquineChloroquine may increase the anticoagulant activities of Hirulog.
ChlorotrianiseneChlorotrianisene may decrease the anticoagulant activities of Hirulog.
CilostazolCilostazol may increase the anticoagulant activities of Hirulog.
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Hirulog.
Citric AcidHirulog may increase the anticoagulant activities of Citric Acid.
ClarithromycinThe therapeutic efficacy of Clarithromycin can be decreased when used in combination with Hirulog.
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Hirulog.
ClonixinClonixin may increase the anticoagulant activities of Hirulog.
ClopidogrelClopidogrel may increase the anticoagulant activities of Hirulog.
CollagenaseThe risk or severity of adverse effects can be increased when Hirulog is combined with Collagenase.
Conjugated Equine EstrogensConjugated Equine Estrogens may decrease the anticoagulant activities of Hirulog.
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Hirulog.
CyclophosphamideThe risk or severity of adverse effects can be increased when Hirulog is combined with Cyclophosphamide.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Hirulog.
D-LimoneneD-Limonene may increase the anticoagulant activities of Hirulog.
Dabigatran etexilateDabigatran etexilate may increase the anticoagulant activities of Hirulog.
DalteparinHirulog may increase the anticoagulant activities of Dalteparin.
DanaparoidHirulog may increase the anticoagulant activities of Danaparoid.
DasatinibDasatinib may increase the anticoagulant activities of Hirulog.
DeferasiroxThe risk or severity of adverse effects can be increased when Hirulog is combined with Deferasirox.
DefibrotideDefibrotide may increase the anticoagulant activities of Hirulog.
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Hirulog.
Deoxycholic AcidThe risk or severity of adverse effects can be increased when Hirulog is combined with Deoxycholic Acid.
DesipramineThe serum concentration of Desipramine can be increased when it is combined with Hirulog.
DesirudinHirulog may increase the anticoagulant activities of Desirudin.
DesmoteplaseDesmoteplase may increase the anticoagulant activities of Hirulog.
DesogestrelThe therapeutic efficacy of Hirulog can be decreased when used in combination with Desogestrel.
DextranHirulog may increase the anticoagulant activities of Dextran.
Dextran 40Hirulog may increase the anticoagulant activities of Dextran 40.
Dextran 70Hirulog may increase the anticoagulant activities of Dextran 70.
Dextran 75Hirulog may increase the anticoagulant activities of Dextran 75.
DiclofenacDiclofenac may increase the anticoagulant activities of Hirulog.
DicoumarolDicoumarol may increase the anticoagulant activities of Hirulog.
DienestrolDienestrol may decrease the anticoagulant activities of Hirulog.
DienogestThe therapeutic efficacy of Hirulog can be decreased when used in combination with Dienogest.
DiethylstilbestrolDiethylstilbestrol may decrease the anticoagulant activities of Hirulog.
DiflunisalDiflunisal may increase the anticoagulant activities of Hirulog.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Hirulog.
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Hirulog.
DipyridamoleDipyridamole may increase the anticoagulant activities of Hirulog.
DitazoleDitazole may increase the anticoagulant activities of Hirulog.
DosulepinThe serum concentration of Dosulepin can be increased when it is combined with Hirulog.
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Hirulog.
DrospirenoneThe therapeutic efficacy of Hirulog can be decreased when used in combination with Drospirenone.
Drotrecogin alfaDrotrecogin alfa may increase the anticoagulant activities of Hirulog.
DroxicamDroxicam may increase the anticoagulant activities of Hirulog.
DydrogesteroneThe therapeutic efficacy of Hirulog can be decreased when used in combination with Dydrogesterone.
DyphyllineThe serum concentration of Dyphylline can be decreased when it is combined with Hirulog.
Edetic AcidEdetic Acid may increase the anticoagulant activities of Hirulog.
EdoxabanEdoxaban may increase the anticoagulant activities of Hirulog.
EnfuvirtideThe serum concentration of Enfuvirtide can be increased when it is combined with Hirulog.
EnoxaparinEnoxaparin may increase the anticoagulant activities of Hirulog.
EpinastineEpinastine may increase the anticoagulant activities of Hirulog.
EpirizoleEpirizole may increase the anticoagulant activities of Hirulog.
EpoprostenolEpoprostenol may increase the anticoagulant activities of Hirulog.
EptifibatideEptifibatide may increase the anticoagulant activities of Hirulog.
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Hirulog.
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Hirulog.
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Hirulog.
EsmirtazapineThe serum concentration of Esmirtazapine can be increased when it is combined with Hirulog.
EstradiolEstradiol may decrease the anticoagulant activities of Hirulog.
EstriolEstriol may decrease the anticoagulant activities of Hirulog.
EstroneEstrone may decrease the anticoagulant activities of Hirulog.
EtanerceptEtanercept may increase the anticoagulant activities of Hirulog.
Ethinyl EstradiolEthinyl Estradiol may decrease the anticoagulant activities of Hirulog.
Ethyl biscoumacetateHirulog may increase the anticoagulant activities of Ethyl biscoumacetate.
EtodolacEtodolac may increase the anticoagulant activities of Hirulog.
EtofenamateEtofenamate may increase the anticoagulant activities of Hirulog.
EtonogestrelThe therapeutic efficacy of Hirulog can be decreased when used in combination with Etonogestrel.
EtoricoxibEtoricoxib may increase the anticoagulant activities of Hirulog.
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Hirulog.
Evening primrose oilEvening primrose oil may increase the anticoagulant activities of Hirulog.
exisulindexisulind may increase the anticoagulant activities of Hirulog.
FenbufenFenbufen may increase the anticoagulant activities of Hirulog.
FenoprofenFenoprofen may increase the anticoagulant activities of Hirulog.
FibrinolysinFibrinolysin may increase the anticoagulant activities of Hirulog.
FloctafenineFloctafenine may increase the anticoagulant activities of Hirulog.
FlunixinFlunixin may increase the anticoagulant activities of Hirulog.
FlurbiprofenFlurbiprofen may increase the anticoagulant activities of Hirulog.
Fondaparinux sodiumFondaparinux sodium may increase the anticoagulant activities of Hirulog.
GarlicThe serum concentration of Hirulog can be decreased when it is combined with Garlic.
GenisteinGenistein may decrease the anticoagulant activities of Hirulog.
GestodeneThe therapeutic efficacy of Hirulog can be decreased when used in combination with Gestodene.
HeminHemin may increase the anticoagulant activities of Hirulog.
HeparinHeparin may increase the anticoagulant activities of Hirulog.
HexestrolHexestrol may decrease the anticoagulant activities of Hirulog.
HMPL-004HMPL-004 may increase the anticoagulant activities of Hirulog.
Hydroxyprogesterone caproateThe therapeutic efficacy of Hirulog can be decreased when used in combination with Hydroxyprogesterone caproate.
Ibritumomab tiuxetanThe risk or severity of adverse effects can be increased when Hirulog is combined with Ibritumomab tiuxetan.
IbrutinibThe risk or severity of adverse effects can be increased when Ibrutinib is combined with Hirulog.
IbudilastIbudilast may increase the anticoagulant activities of Hirulog.
IbuprofenIbuprofen may increase the anticoagulant activities of Hirulog.
IbuproxamIbuproxam may increase the anticoagulant activities of Hirulog.
IcatibantIcatibant may increase the anticoagulant activities of Hirulog.
Icosapent ethylIcosapent ethyl may increase the anticoagulant activities of Hirulog.
IfenprodilIfenprodil may increase the anticoagulant activities of Hirulog.
IloprostIloprost may increase the anticoagulant activities of Hirulog.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Hirulog.
IndomethacinIndomethacin may increase the anticoagulant activities of Hirulog.
IndoprofenIndoprofen may increase the anticoagulant activities of Hirulog.
IsoxicamIsoxicam may increase the anticoagulant activities of Hirulog.
KebuzoneKebuzone may increase the anticoagulant activities of Hirulog.
KetoprofenKetoprofen may increase the anticoagulant activities of Hirulog.
KetorolacKetorolac may increase the anticoagulant activities of Hirulog.
LeflunomideLeflunomide may increase the anticoagulant activities of Hirulog.
LepirudinLepirudin may increase the anticoagulant activities of Hirulog.
LevonorgestrelThe therapeutic efficacy of Hirulog can be decreased when used in combination with Levonorgestrel.
LimaprostThe risk or severity of adverse effects can be increased when Limaprost is combined with Hirulog.
LornoxicamLornoxicam may increase the anticoagulant activities of Hirulog.
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Hirulog.
LoxoprofenLoxoprofen may increase the anticoagulant activities of Hirulog.
LumiracoxibLumiracoxib may increase the anticoagulant activities of Hirulog.
Magnesium salicylateMagnesium salicylate may increase the anticoagulant activities of Hirulog.
MasoprocolMasoprocol may increase the anticoagulant activities of Hirulog.
Meclofenamic acidMeclofenamic acid may increase the anticoagulant activities of Hirulog.
MedrogestoneThe therapeutic efficacy of Hirulog can be decreased when used in combination with Medrogestone.
Medroxyprogesterone acetateThe therapeutic efficacy of Hirulog can be decreased when used in combination with Medroxyprogesterone acetate.
Mefenamic acidMefenamic acid may increase the anticoagulant activities of Hirulog.
Megestrol acetateThe therapeutic efficacy of Hirulog can be decreased when used in combination with Megestrol acetate.
MeloxicamMeloxicam may increase the anticoagulant activities of Hirulog.
MesalazineMesalazine may increase the anticoagulant activities of Hirulog.
MestranolMestranol may decrease the anticoagulant activities of Hirulog.
MetamizoleMetamizole may increase the anticoagulant activities of Hirulog.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Hirulog.
MilrinoneMilrinone may increase the anticoagulant activities of Hirulog.
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Hirulog.
Mycophenolate mofetilMycophenolate mofetil may increase the anticoagulant activities of Hirulog.
Mycophenolic acidMycophenolic acid may increase the anticoagulant activities of Hirulog.
NabumetoneNabumetone may increase the anticoagulant activities of Hirulog.
NadroparinHirulog may increase the anticoagulant activities of Nadroparin.
NaftifineNaftifine may increase the anticoagulant activities of Hirulog.
NaproxenNaproxen may increase the anticoagulant activities of Hirulog.
NCX 4016NCX 4016 may increase the anticoagulant activities of Hirulog.
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Hirulog.
NepafenacNepafenac may increase the anticoagulant activities of Hirulog.
Niflumic AcidNiflumic Acid may increase the anticoagulant activities of Hirulog.
NimesulideNimesulide may increase the anticoagulant activities of Hirulog.
NintedanibThe risk or severity of adverse effects can be increased when Hirulog is combined with Nintedanib.
NorethisteroneThe therapeutic efficacy of Hirulog can be decreased when used in combination with Norethisterone.
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Hirulog.
ObinutuzumabThe risk or severity of adverse effects can be increased when Hirulog is combined with Obinutuzumab.
OlopatadineOlopatadine may increase the anticoagulant activities of Hirulog.
OlsalazineOlsalazine may increase the anticoagulant activities of Hirulog.
Omacetaxine mepesuccinateThe risk or severity of adverse effects can be increased when Hirulog is combined with Omacetaxine mepesuccinate.
Omega-3 fatty acidsOmega-3 fatty acids may increase the anticoagulant activities of Hirulog.
OrgoteinOrgotein may increase the anticoagulant activities of Hirulog.
OtamixabanHirulog may increase the anticoagulant activities of Otamixaban.
OxaprozinOxaprozin may increase the anticoagulant activities of Hirulog.
OxyphenbutazoneOxyphenbutazone may increase the anticoagulant activities of Hirulog.
ParecoxibParecoxib may increase the anticoagulant activities of Hirulog.
ParnaparinParnaparin may increase the anticoagulant activities of Hirulog.
Pentosan PolysulfatePentosan Polysulfate may increase the anticoagulant activities of Hirulog.
PentoxifyllinePentoxifylline may increase the anticoagulant activities of Hirulog.
PethidineThe risk or severity of adverse effects can be increased when Hirulog is combined with Pethidine.
PhenindionePhenindione may increase the anticoagulant activities of Hirulog.
PhenprocoumonPhenprocoumon may increase the anticoagulant activities of Hirulog.
PhenylbutazonePhenylbutazone may increase the anticoagulant activities of Hirulog.
PimecrolimusPimecrolimus may increase the anticoagulant activities of Hirulog.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Hirulog.
PirfenidonePirfenidone may increase the anticoagulant activities of Hirulog.
PiroxicamPiroxicam may increase the anticoagulant activities of Hirulog.
PlasminPlasmin may increase the anticoagulant activities of Hirulog.
Polyestradiol phosphatePolyestradiol phosphate may decrease the anticoagulant activities of Hirulog.
PrasugrelPrasugrel may increase the anticoagulant activities of Hirulog.
ProgesteroneThe therapeutic efficacy of Hirulog can be decreased when used in combination with Progesterone.
PropacetamolPropacetamol may increase the anticoagulant activities of Hirulog.
Protein CHirulog may increase the anticoagulant activities of Protein C.
ProtocatechualdehydeHirulog may increase the anticoagulant activities of Protocatechualdehyde.
ProtriptylineThe serum concentration of Protriptyline can be increased when it is combined with Hirulog.
PTC299PTC299 may increase the anticoagulant activities of Hirulog.
QuinestrolQuinestrol may decrease the anticoagulant activities of Hirulog.
ResveratrolResveratrol may increase the anticoagulant activities of Hirulog.
ReteplaseReteplase may increase the anticoagulant activities of Hirulog.
ReviparinHirulog may increase the anticoagulant activities of Reviparin.
RidogrelRidogrel may increase the anticoagulant activities of Hirulog.
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Hirulog.
RivaroxabanHirulog may increase the anticoagulant activities of Rivaroxaban.
RofecoxibRofecoxib may increase the anticoagulant activities of Hirulog.
RosiglitazoneRosiglitazone may increase the anticoagulant activities of Hirulog.
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Hirulog.
SalicylamideSalicylamide may increase the anticoagulant activities of Hirulog.
Salicylic acidSalicylic acid may increase the anticoagulant activities of Hirulog.
SalsalateSalsalate may increase the anticoagulant activities of Hirulog.
SCH-530348SCH-530348 may increase the anticoagulant activities of Hirulog.
SelexipagSelexipag may increase the anticoagulant activities of Hirulog.
SeratrodastSeratrodast may increase the anticoagulant activities of Hirulog.
SevofluraneSevoflurane may increase the anticoagulant activities of Hirulog.
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Hirulog.
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Hirulog.
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Hirulog.
SRT501SRT501 may increase the anticoagulant activities of Hirulog.
St. John's WortThe metabolism of Hirulog can be increased when combined with St. John's Wort.
StreptokinaseStreptokinase may increase the anticoagulant activities of Hirulog.
SugammadexSugammadex may increase the anticoagulant activities of Hirulog.
SulfasalazineSulfasalazine may increase the anticoagulant activities of Hirulog.
SulindacSulindac may increase the anticoagulant activities of Hirulog.
SulodexideHirulog may increase the anticoagulant activities of Sulodexide.
SuprofenSuprofen may increase the anticoagulant activities of Hirulog.
Synthetic Conjugated Estrogens, ASynthetic Conjugated Estrogens, A may decrease the anticoagulant activities of Hirulog.
Synthetic Conjugated Estrogens, BSynthetic Conjugated Estrogens, B may decrease the anticoagulant activities of Hirulog.
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Hirulog.
TemsirolimusThe risk or severity of adverse effects can be increased when Hirulog is combined with Temsirolimus.
TenecteplaseTenecteplase may increase the anticoagulant activities of Hirulog.
TenoxicamTenoxicam may increase the anticoagulant activities of Hirulog.
TepoxalinTepoxalin may increase the anticoagulant activities of Hirulog.
TeriflunomideTeriflunomide may increase the anticoagulant activities of Hirulog.
TesmilifeneTesmilifene may increase the anticoagulant activities of Hirulog.
TheophyllineThe serum concentration of Theophylline can be decreased when it is combined with Hirulog.
TianeptineThe serum concentration of Tianeptine can be increased when it is combined with Hirulog.
Tiaprofenic acidTiaprofenic acid may increase the anticoagulant activities of Hirulog.
TiboloneTibolone may increase the anticoagulant activities of Hirulog.
TicagrelorTicagrelor may increase the anticoagulant activities of Hirulog.
TiclopidineTiclopidine may increase the anticoagulant activities of Hirulog.
TinzaparinTinzaparin may increase the anticoagulant activities of Hirulog.
TipranavirThe serum concentration of Hirulog can be decreased when it is combined with Tipranavir.
TirofibanTirofiban may increase the anticoagulant activities of Hirulog.
Tolfenamic AcidTolfenamic Acid may increase the anticoagulant activities of Hirulog.
TolmetinTolmetin may increase the anticoagulant activities of Hirulog.
TositumomabThe risk or severity of adverse effects can be increased when Hirulog is combined with Tositumomab.
TranilastTranilast may increase the anticoagulant activities of Hirulog.
TrapidilTrapidil may increase the anticoagulant activities of Hirulog.
TreprostinilTreprostinil may increase the anticoagulant activities of Hirulog.
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Hirulog.
TriflusalTriflusal may increase the anticoagulant activities of Hirulog.
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Hirulog.
Trisalicylate-cholineTrisalicylate-choline may increase the anticoagulant activities of Hirulog.
UrokinaseUrokinase may increase the anticoagulant activities of Hirulog.
ValdecoxibValdecoxib may increase the anticoagulant activities of Hirulog.
Vitamin EVitamin E may increase the anticoagulant activities of Hirulog.
VorapaxarThe risk or severity of adverse effects can be increased when Vorapaxar is combined with Hirulog.
WarfarinWarfarin may increase the anticoagulant activities of Hirulog.
XimelagatranHirulog may increase the anticoagulant activities of Ximelagatran.
ZaltoprofenZaltoprofen may increase the anticoagulant activities of Hirulog.
ZeranolZeranol may decrease the anticoagulant activities of Hirulog.
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Hirulog.
ZileutonZileuton may increase the anticoagulant activities of Hirulog.
ZomepiracZomepirac may increase the anticoagulant activities of Hirulog.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Thrombospondin receptor activity
Specific Function:
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.
Gene Name:
F2
Uniprot ID:
P00734
Molecular Weight:
70036.295 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23