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Identification
NameUrea
Accession NumberDB03904  (EXPT03203)
TypeSmall Molecule
GroupsApproved
Description

A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids. [PubChem]

Structure
Thumb
SynonymsNot Available
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Calmurid Crmcream100 mgtopicalGalderma Canada Inc1994-12-311999-07-27Canada
Carbamex 330mgmstablet330 mgoralTherapeutic Foods Co.1989-12-152009-07-24Canada
Urederm Cream 10%cream10 %topicalChartwell Industries (Canada) Ltd.1995-12-312009-06-19Canada
Uremol 10 Crm 10%cream10 %topicalTrans Canaderm Inc.1987-12-312000-10-27Canada
Uremol 10 Lotion 10%lotion10 %topicalTrans Canaderm Inc.1979-12-312000-10-27Canada
Velvelan Crm 10%cream10 %topicalMerck Frosst Canada & Cie, Merck Frosst Canada & Co.1978-12-311997-08-14Canada
Velvelan Lot 10%lotion10 %topicalMerck Frosst Canada & Cie, Merck Frosst Canada & Co.1978-12-311997-08-14Canada
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Aluveacream39 g/100gtopicalMerz Pharmaceuticals, LLC2011-04-15Not applicableUs
Carb-O-philiccream10 g/100gtopicalGeritrex Corp2015-01-202016-01-05Us
Carb-O-philiccream20 g/100gtopicalGeritrex Corp2015-01-212016-01-05Us
Cem-ureasolution.45 mL/mLtopicalPru Gen, Inc.2011-07-01Not applicableUs
Gehwol Fusskraft Callus Softenerliquid250 mg/mLtopicalEduard Gerlach Gmb H2008-03-24Not applicableUs
Gehwol Med Calluscream180 mg/mLtopicalEduard Gerlach Gmb H2010-07-08Not applicableUs
Gehwol Med Lipidrocream100 mg/mLtopicalEduard Gerlach Gmb H2005-06-25Not applicableUs
Gordons Urea 40ointment.4 g/gtopicalGordon Laboratories2010-07-16Not applicableUs
Keralaccream470 mg/gtopicalBrava Pharmaceuticals, Llc2011-07-01Not applicableUs
Rea Lo 39cream390 mg/gtopicalCrown Laboratories2014-09-01Not applicableUs
Rea Lo 40lotion400 mg/mLtopicalCrown Laboratories2006-05-22Not applicableUs
Rea Lo 40cream400 mg/gtopicalCrown Laboratories2006-05-22Not applicableUs
Remevencream71 g/142gtopicalStratus Pharmaceuticals, Inc2008-06-18Not applicableUs
Umecta Mousse Ureaaerosol, foam400 mg/gtopicalInnocutis Holdings LLC2007-09-01Not applicableUs
Umecta Pd Ureasuspension400 mg/gtopicalInnocutis Holdings LLC2007-06-01Not applicableUs
Umecta Pd Ureaemulsion400 mg/gtopicalInnocutis Holdings LLC2007-06-01Not applicableUs
Umecta Ureafilm400 mg/gtopicalInnocutis Holdings LLC2006-06-01Not applicableUs
Umecta Ureaemulsion400 mg/gtopicalInnocutis Holdings LLC2004-06-01Not applicableUs
Uramaxinlotion450 mg/gtopicalMedimetriks Pharmaceuticals, Inc.2009-06-02Not applicableUs
Uramaxinaerosol, foam20 g/100gtopicalMedimetriks Pharmaceuticals Inc2009-03-13Not applicableUs
Uramaxincream450 mg/gtopicalMedimetriks Pharmaceuticals, Inc.2009-01-01Not applicableUs
Uramaxin Gtgel.45 mL/mLtopicalMedimetriks Pharmaceuticals, Inc.2010-07-08Not applicableUs
Uramaxin Padscloth450 mg/gtopicalMedimetriks Pharmaceuticals, Inc.2010-10-07Not applicableUs
Uramaxin Tscream450 mg/gtopicalMedimetriks Pharmaceuticals, Inc.2010-04-20Not applicableUs
Ure-Kcream500 mg/gtopicalSolutech Pharmaceuticals Llc2016-02-01Not applicableUs
Ureacream450 mg/gtopicalExact Rx, Inc.2011-08-01Not applicableUs
Ureacream390 mg/gtopicalAscend Laboratories, LLC2013-06-012016-02-25Us
Urealotion40 g/100mLtopicalPerrigo New York Inc2010-06-04Not applicableUs
Ureagel450 mg/gtopicalLibertas Pharma, Inc.2011-10-28Not applicableUs
Ureaemulsion500 mg/mLtopicalExact Rx, Inc.2011-08-01Not applicableUs
Urealotion400 mg/mLtopicalAscend Laboratories, LLC2012-01-162016-03-01Us
Ureagel40 g/100mLtopicalPerrigo New York Inc2011-06-13Not applicableUs
Ureasuspension500 mg/gtopicalExact Rx, Inc.2011-08-01Not applicableUs
Ureaemulsion50 g/100gtopicalACELLA PHARMACEUTICALS2010-11-08Not applicableUs
Ureagel400 mg/mLtopicalAUSTIN PHARMACEUTICALS, LLC2010-11-262015-12-29Us
Ureacream400 mg/gtopicalAscend Laboratories, LLC2012-01-162016-02-25Us
Ureacream400 mg/gtopicalPerrigo New York Inc2010-08-17Not applicableUs
Ureacream500 mg/gtopicalExact Rx, Inc.2011-08-01Not applicableUs
Urealotion40 g/100gtopicalTrinity Pharmaceuticals, LLC2014-09-19Not applicableUs
Ureacream390 mg/gtopicalAUSTIN PHARMACEUTICALS, LLC2011-03-09Not applicableUs
Ureacream39 g/100gtopicalTrinity Pharmaceuticals, LLC2013-12-02Not applicableUs
Ureacream40 g/100gtopicalTrinity Pharmaceuticals, LLC2014-09-01Not applicableUs
Urealotion1 mL/10mLtopicalStratus Pharmaceuticals, Inc2010-05-20Not applicableUs
Ureagel450 mg/mLtopicalExact Rx, Inc.2011-08-01Not applicableUs
Ureacream450 mg/gtopicalLibertas Pharma, Inc.2011-10-07Not applicableUs
Ureaemulsion500 mg/gtopicalExact Rx, Inc.2011-08-01Not applicableUs
Ureasolution400 mg/gtopicalAcella Pharmaceuticals, LLC2009-06-22Not applicableUs
Ureacream8.5 g/85gtopicalStratus Pharmaceuticals, Inc2010-05-01Not applicableUs
Urea 47% Creamcream470 mg/gtopicalRosemar Labs, LLC2011-07-01Not applicableUs
Urea Hydrating Topicalaerosol, foam35 g/100gtopicalACELLA PHARMACEUTICALS2010-11-09Not applicableUs
Urevazcream440 mg/gtopicalSterling Knight Pharmaceuticals, Llc2015-05-21Not applicableUs
Utopiccream410 mg/gtopicalArtesa Labs, Llc2011-08-15Not applicableUs
X-viategel6.726 g/15mLtopicalStratus Pharmaceuticals, Inc2006-05-03Not applicableUs
Yougreen Fointment7.5 g/30gtopicalDong Sung Pharm Co., Ltd.2014-08-20Not applicableUs
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
Calmurid HC CrmGalderma Canada Inc
Dr. Scholl's Cracked Heel Relief CreamSchering Plough Canada Inc
Flexitol Heel BalmLaderma Trading Pty Ltd.
Heel BalmTanta Pharmaceuticals Inc
Hydrophil OntOmega Laboratories Ltd
Kerasal Topical SolutionSpectropharm Dermatology, A Division Of Draxis Health Inc.
PedipakTotal Pharmacy Supply, Inc.
Psoricare Crm 3%Avacare, Division Of Jeunique International Inc.
Thomas Formula No 17Thomas Hair And Scalp Specialists
Thomas Formula No 47Thomas Hair And Scalp Specialists
Ti-U-lac HC LotionMerit Industries Inc.
Ti-U-lac LotionMerit Industries Inc.
Uremol HCGlaxosmithkline Inc
SaltsNot Available
CategoriesNot Available
UNII8W8T17847W
CAS number57-13-6
WeightAverage: 60.0553
Monoisotopic: 60.03236276
Chemical FormulaCH4N2O
InChI KeyInChIKey=XSQUKJJJFZCRTK-UHFFFAOYSA-N
InChI
InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)
IUPAC Name
urea
SMILES
NC(N)=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as ureas. These are compounds containing two amine groups joined by a carbonyl (C=O) functional group.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassOrganic carbonic acids and derivatives
Sub ClassUreas
Direct ParentUreas
Alternative Parents
Substituents
  • Urea
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Pharmacology
Indication
  • 10% hydrate skin
  • 15% accelerate fibrin degradation
  • 20-30% are antipruritic, break down keratin, decrease the thickness of the stratum corneum and are used in scaling conditions such as ichthysosis
  • 40% are proteolytic and may be used to dissolve and peel dystrophic nails

[Patient Self Care, 2010]
PharmacodynamicsAs a humectant, urea draws water into the striatum corneum.
Mechanism of actionNot Available
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
Pathways
PathwayCategorySMPDB ID
D-Arginine and D-Ornithine MetabolismMetabolicSMP00036
Quinethazone Action PathwayDrug actionSMP00091
Metolazone Action PathwayDrug actionSMP00105
Hartnup DisorderDiseaseSMP00189
IminoglycinuriaDiseaseSMP00193
ArgininemiaDiseaseSMP00357
Blue diaper syndromeDiseaseSMP00583
CystinuriaDiseaseSMP00723
Arginine and Proline MetabolismMetabolicSMP00020
Urea CycleMetabolicSMP00059
Indapamide Action PathwayDrug actionSMP00110
Trichlormethiazide Action PathwayDrug actionSMP00121
Amiloride Action PathwayDrug actionSMP00133
Ornithine Transcarbamylase Deficiency (OTC Deficiency)DiseaseSMP00205
Prolinemia Type IIDiseaseSMP00208
Hyperprolinemia Type IDiseaseSMP00361
Citrullinemia Type IDiseaseSMP00001
Carbamoyl Phosphate Synthetase DeficiencyDiseaseSMP00002
Chlorothiazide Action PathwayDrug actionSMP00078
Ethacrynic Acid Action PathwayDrug actionSMP00097
Hydroflumethiazide Action PathwayDrug actionSMP00108
Furosemide Action PathwayDrug actionSMP00115
Glucose Transporter Defect (SGLT2)DiseaseSMP00184
Ornithine Aminotransferase Deficiency (OAT Deficiency)DiseaseSMP00363
Argininosuccinic AciduriaDiseaseSMP00003
Hydrochlorothiazide Action PathwayDrug actionSMP00100
Torsemide Action PathwayDrug actionSMP00118
Chlorthalidone Action PathwayDrug actionSMP00122
Triamterene Action PathwayDrug actionSMP00132
Spironolactone Action PathwayDrug actionSMP00134
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9513
Blood Brain Barrier+0.981
Caco-2 permeable-0.8956
P-glycoprotein substrateNon-substrate0.8517
P-glycoprotein inhibitor INon-inhibitor0.982
P-glycoprotein inhibitor IINon-inhibitor0.9875
Renal organic cation transporterNon-inhibitor0.9343
CYP450 2C9 substrateNon-substrate0.7982
CYP450 2D6 substrateNon-substrate0.793
CYP450 3A4 substrateNon-substrate0.8449
CYP450 1A2 substrateNon-inhibitor0.9661
CYP450 2C9 inhibitorNon-inhibitor0.8771
CYP450 2D6 inhibitorNon-inhibitor0.9878
CYP450 2C19 inhibitorNon-inhibitor0.974
CYP450 3A4 inhibitorNon-inhibitor0.9724
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9695
Ames testNon AMES toxic0.9133
CarcinogenicityNon-carcinogens0.6955
BiodegradationReady biodegradable0.5354
Rat acute toxicity0.8822 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.981
hERG inhibition (predictor II)Non-inhibitor0.9824
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Creamtopical39 g/100g
Creamtopical100 mg
Creamtopical
Creamtopical10 g/100g
Creamtopical20 g/100g
Tabletoral330 mg
Solutiontopical.45 mL/mL
Liquidtopical250 mg/mL
Creamtopical180 mg/mL
Creamtopical100 mg/mL
Ointmenttopical.4 g/g
Ointmenttopical
Liquidtopical
Kit
Creamtopical390 mg/g
Creamtopical400 mg/g
Lotiontopical400 mg/mL
Creamtopical71 g/142g
Lotiontopical
Aerosol, foamtopical400 mg/g
Suspensiontopical400 mg/g
Emulsiontopical400 mg/g
Filmtopical400 mg/g
Aerosol, foamtopical20 g/100g
Lotiontopical450 mg/g
Geltopical.45 mL/mL
Clothtopical450 mg/g
Creamtopical40 g/100g
Creamtopical450 mg/g
Creamtopical500 mg/g
Creamtopical8.5 g/85g
Emulsiontopical50 g/100g
Emulsiontopical500 mg/mL
Emulsiontopical500 mg/g
Geltopical40 g/100mL
Geltopical400 mg/mL
Geltopical450 mg/mL
Geltopical450 mg/g
Lotiontopical1 mL/10mL
Lotiontopical40 g/100g
Lotiontopical40 g/100mL
Solutiontopical400 mg/g
Suspensiontopical500 mg/g
Creamtopical470 mg/g
Aerosol, foamtopical35 g/100g
Creamtopical10 %
Creamtopical440 mg/g
Creamtopical410 mg/g
Lotiontopical10 %
Geltopical6.726 g/15mL
Ointmenttopical7.5 g/30g
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point132.7 °CPhysProp
water solubility5.45E+005 mg/L (at 25 °C)YALKOWSKY,SH (1989)
logP-2.11HANSCH,C ET AL. (1995)
logS0.96ADME Research, USCD
Caco2 permeability-5.34ADME Research, USCD
pKa0.1 (at 21 °C)PERRIN,DD (1965)
Predicted Properties
PropertyValueSource
Water Solubility412.0 mg/mLALOGPS
logP-1.8ALOGPS
logP-1.4ChemAxon
logS0.84ALOGPS
pKa (Strongest Acidic)15.73ChemAxon
pKa (Strongest Basic)-2.4ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area69.11 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity13.14 m3·mol-1ChemAxon
Polarizability5.1 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
GC-MSGC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies)splash10-0002-0900000000-234545ed5860ba077237View in MoNA
GC-MSGC-MS Spectrum - GC-MS (2 TMS)splash10-0079-3900000000-0ef80e5f5cd9dd6bd213View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-03di-9000000000-8f09c5d6f5e002dfa52eView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-03dl-9000000000-3d983e9f9115869f55c8View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-001i-9000000000-9404d66c59d266164c23View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-03di-9000000000-4bdf0d3bd74007ba840aView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-03di-9000000000-7184b34bac3a316d9feaView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0006-9000000000-37fd015e8c20febde95aView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0a4i-9000000000-2fc4ec950c571662bb31View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0a4l-9000000000-3443c9c73d9a3f03e398View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0006-9000000000-11d83d6bda76c25ec73fView in MoNA
MSMass Spectrum (Electron Ionization)splash10-02tc-9000000000-871569893ccfa5dd5395View in MoNA
1D NMR13C NMR SpectrumNot Available
1D NMR1H NMR SpectrumNot Available
1D NMR1H NMR SpectrumNot Available
References
Synthesis Reference

Ryo Yoshida, Haruhiko Katoh, Seizo Sumida, Ichiki Takemoto, Junya Takahashi, Katsuzo Kamoshita, “Urea derivatives, and their production and use.” U.S. Patent US4334912, issued 0000.

US4334912
General ReferencesNot Available
External Links
ATC CodesNot Available
AHFS CodesNot Available
PDB Entries
FDA labelNot Available
MSDSNot Available
Interactions
Drug InteractionsNot Available
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Manganese ion binding
Specific Function:
Not Available
Gene Name:
ARG1
Uniprot ID:
P05089
Molecular Weight:
34734.655 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate ex...
Gene Name:
CA2
Uniprot ID:
P00918
Molecular Weight:
29245.895 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
VEEV
Pharmacological action
unknown
General Function:
Structural molecule activity
Specific Function:
Capsid protein possesses a protease activity that results in its autocatalytic cleavage from the nascent structural protein. Following its self-cleavage, the capsid protein transiently associates with ribosomes, and within several minutes the protein binds to viral RNA and rapidly assembles into icosaedric core particles. The resulting nucleocapsid eventually associates with the cytoplasmic dom...
Gene Name:
Not Available
Uniprot ID:
P09592
Molecular Weight:
138349.755 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Transcription regulatory region dna binding
Specific Function:
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where i...
Gene Name:
CTNNB1
Uniprot ID:
P35222
Molecular Weight:
85495.94 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Escherichia coli O157:H7
Pharmacological action
unknown
General Function:
Oxidoreductase activity, acting on a sulfur group of donors
Specific Function:
The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase.
Gene Name:
yedY
Uniprot ID:
Q8XB74
Molecular Weight:
37356.555 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
unknown
General Function:
Nadp binding
Specific Function:
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Gene Name:
folA
Uniprot ID:
P0ABQ4
Molecular Weight:
17999.21 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Urea transmembrane transporter activity
Specific Function:
Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism.
Gene Name:
SLC14A2
Uniprot ID:
Q15849
Molecular Weight:
101207.965 Da
References
  1. Wall SM, Han JS, Chou CL, Knepper MA: Kinetics of urea and water permeability activation by vasopressin in rat terminal IMCD. Am J Physiol. 1992 Jun;262(6 Pt 2):F989-98. [PubMed:1320335 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Water transmembrane transporter activity
Specific Function:
Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between th...
Gene Name:
SLC14A1
Uniprot ID:
Q13336
Molecular Weight:
42527.93 Da
References
  1. Ripoche P, Rousselet G: [Urea transporters]. Nephrologie. 1996;17(7):383-8. [PubMed:9019665 ]
  2. Olives B, Mattei MG, Huet M, Neau P, Martial S, Cartron JP, Bailly P: Kidd blood group and urea transport function of human erythrocytes are carried by the same protein. J Biol Chem. 1995 Jun 30;270(26):15607-10. [PubMed:7797558 ]
Comments
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Drug created on June 13, 2005 07:24 / Updated on December 08, 2015 15:58