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Identification
NameHydrocortisone
Accession NumberDB00741  (APRD01019, DB07886)
TypeSmall Molecule
GroupsApproved, Vet Approved
Description

The main glucocorticoid secreted by the adrenal cortex. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. [PubChem]

Structure
Thumb
Synonyms
(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
(11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione
11beta-hydrocortisone
11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
11β-hydrocortisone
17-Hydroxycorticosterone
4-Pregnen-11beta,17alpha,21-triol-3,20-dione
Cortisol
Hidrocortisona
Hydrocortisone
Hydrocortisonum
Kendall's compound F
Reichstein's substance M
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
A-hydrocort Inj 1000mg/8mlpowder for solution1 gintramuscular; intravenousHospira Healthcare Corporation1993-12-312012-08-03Canada
A-hydrocort Inj 100mg/2mlpowder for solution100 mgintramuscular; intravenousHospira Healthcare Corporation1992-12-312012-08-03Canada
A-hydrocort Inj 250mg/2mlpowder for solution250 mgintramuscular; intravenousHospira Healthcare Corporation1992-12-312012-08-03Canada
A-hydrocort Inj 500mg/4mlpowder for solution500 mgintramuscular; intravenousHospira Healthcare Corporation1992-12-312012-08-03Canada
Alocort 1% - Crmcream1 %topicalUcb Inc1996-12-061998-04-21Canada
Aquacort Lotion 2.5%lotion2.5 %topicalMerit Industries Inc.1992-12-312002-05-14Canada
Barriere HC 1%jelly; cream1 %topicalAllen & Hanburys A Glaxo Canada Ltd. Co.1979-12-311998-07-29Canada
Bioelements Immediate Comfortlotion.088 mL/88mLtopicalBioelements, Inc.2012-08-23Not applicableUs
Cortamed Ont 25 mg/gointment25 mgophthalmicSandoz Canada Incorporated1992-12-31Not applicableCanada
Cortate Crm 1%cream10 mgtopicalSchering Plough Canada Inc1980-12-312013-07-31Canada
Cortate Ont 1%ointment10 mgtopicalSchering Plough Canada Inc1980-12-312013-07-31Canada
Corteftablet5 mg/1oralPharmacia and Upjohn Company1952-12-15Not applicableUs
Corteftablet20 mg/1oralPharmacia and Upjohn Company1952-12-15Not applicableUs
Corteftablet10 mg/1oralPharmacia and Upjohn Company1952-12-15Not applicableUs
Cortef Tablets 10mgtablet10 mgoralPfizer Canada Inc1954-12-31Not applicableCanada
Cortef Tablets 20 mgtablet20 mgoralPfizer Canada Inc1954-12-31Not applicableCanada
Cortenemaenema100 mgrectalAptalis Pharma Canada Inc1995-12-31Not applicableCanada
Cortenemaenema100 mg/60mLrectalANIP Acquisition Company2012-08-10Not applicableUs
Cortenema Sus 100mg/60mlenema; suspension100 mgrectalInterfalk Canada Inc.1986-12-311996-09-09Canada
Corticreme 0.1%cream1 mgtopicalRougier Pharma Division Of Ratiopharm Inc1980-12-311999-09-27Canada
Corticreme 1%cream10 mgtopicalRougier Pharma Division Of Ratiopharm Inc1980-12-311999-09-27Canada
Cortifoamaerosol10 %rectalPaladin Labs Inc1983-12-31Not applicableCanada
Cortifoamaerosol, foam1500 mg/15gtopicalMEDA Pharmaceuticals2015-06-30Not applicableUs
Cortifoamaerosol, foam1500 mg/15grectalAlaven Pharmaceutical LLC1982-02-12Not applicableUs
Cortiment-10 Sup 10mgsuppository10 mgrectalHoechst Marion Roussel Canada Inc.1995-12-311997-02-28Canada
Cortiment-40 Sup 40mgsuppository40 mgrectalHoechst Marion Roussel Canada Inc.1995-12-311997-02-28Canada
Emo Cort Cream 2.5%cream2.5 %topicalGlaxosmithkline Inc1983-12-31Not applicableCanada
Emo Cort Lotion 2.5%lotion2.5 %topicalGlaxosmithkline Inc1983-12-31Not applicableCanada
Emo Cort Sol 2.5% USPsolution2.5 %topicalGlaxosmithkline Inc1986-12-312012-12-10Canada
Hycort Retention Enema 100mg/60mlenema100 mgrectalValeant Canada Lp Valeant Canada S.E.C.1986-12-312014-04-22Canada
Hydrocortisonetablet20 mg/1oralGreenstone LLC2013-02-20Not applicableUs
Hydrocortisonetablet10 mg/1oralGreenstone LLC2013-02-20Not applicableUs
Hydrocortisonetablet5 mg/1oralGreenstone LLC2013-02-20Not applicableUs
Hydrocortisonetablet5 mg/1oralKAISER FOUNDATION HOSPITALS2014-09-03Not applicableUs
Hydrocortisoneenema100 mg/60mLrectalANIP Acquisition Company2012-08-16Not applicableUs
Hydrocortisonesuspension100 mg/60mLrectalBreckenridge Pharmaceutical, Inc.2010-10-15Not applicableUs
Hydrocortisone Butyratesolution1 mg/mLtopicalRouses Point Pharm2010-02-24Not applicableUs
Hydrocortisone Butyrateointment1 mg/gtopicalRouses Point Pharm2009-09-01Not applicableUs
Hydrocortisone Butyratecream1 mg/gtopicalOceanside Pharmaceuticals2013-07-03Not applicableUs
Hydrocortisone Butyratecream1 mg/gtopicalRouses Point Pharm2009-09-01Not applicableUs
Hydrocortisone Butyratecream1 mg/gtopicalOceanside Pharmaceuticals2013-07-03Not applicableUs
Hydrocortisone Butyratecream1 mg/gtopicalRebel Distributors Corp2009-09-01Not applicableUs
Hydrocortisone Butyratecream1 mg/gtopicalPhysicians Total Care, Inc.2011-04-25Not applicableUs
Hydrocortisone Butyratecream1 mg/gtopicalREMEDYREPACK INC.2014-04-01Not applicableUs
Hydrocortisone Butyrate Cream (lipid) 0.1%cream1 mg/gtopicalMetacon Labs2013-08-22Not applicableUs
Hydrocortisone Cream 1%cream1 gtopicalD.C. Labs Limited1982-12-312005-07-19Canada
Hydrocortisone Crm 1%cream10 mgtopicalStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1965-12-312002-07-31Canada
Hydrocortisone Ointment 1%ointment1 %topicalD.C. Labs Limited1966-12-312003-07-11Canada
Hydrocortisone Sodium Succinate for Injectionpowder for solution500 mgintramuscular; intravenousTeva Canada Limited1994-12-31Not applicableCanada
Hydrocortisone Sodium Succinate for Injectionpowder for solution100 mgintramuscular; intravenousTeva Canada Limited1994-12-31Not applicableCanada
Hydrocortisone Sodium Succinate for Injectionpowder for solution250 mgintramuscular; intravenousTeva Canada Limited1994-04-21Not applicableCanada
Hydrocortisone Sodium Succinate Injectionpowder for solution1 gintramuscular; intravenousTeva Canada Limited1994-12-31Not applicableCanada
Hydroval Cream 0.2%cream0.2 %topicalTaropharma, A Division Of Taro Pharmaceuticals Inc.2000-12-18Not applicableCanada
Hydroval Ointment 0.2%ointment0.2 %topicalTaropharma, A Division Of Taro Pharmaceuticals Inc.2000-12-18Not applicableCanada
Locoidcream1 mg/gtopicalOnset Dermatologics, LLC2013-07-03Not applicableUs
Locoidlotion1 mg/mLtopicalOnset Dermatologics, LLC2013-07-03Not applicableUs
Locoidsolution1 mg/mLtopicalOnset Dermatologics, LLC2013-07-02Not applicableUs
Locoidointment1 mg/gtopicalOnset Dermatologics, LLC2013-07-08Not applicableUs
Locoid Lipocreamcream1 mg/gtopicalOnset Dermatologics LLC2013-07-03Not applicableUs
Pandelcream1 mg/gtopicalPharma Derm, A Division Of Nycomed Us Inc.1997-02-282015-12-29Us
Pandelcream1 mg/gtopicalPharma Derm A Division Of Fougera Pharmaceuticals Inc.1997-02-28Not applicableUs
Rectocort Ontointment750 mgrectal; topicalWelcker Lyster Ltd., Division Of Technilab Inc.1980-12-311999-09-17Canada
Rectocort Supsuppository10 mgrectalWelcker Lyster Ltd., Division Of Technilab Inc.1975-12-311999-09-17Canada
Sarna HClotion2.5 %topicalGlaxosmithkline Inc1990-12-312014-06-02Canada
Solu-cortefinjection, powder, for solution100 mg/2mLintramuscular; intravenousPharmacia And Upjohn Company Llc1955-04-27Not applicableUs
Solu-cortefinjection, powder, for solution1000 mg/8mLintramuscular; intravenousPharmacia And Upjohn Company Llc1955-04-27Not applicableUs
Solu-cortefinjection, powder, for solution100 mg/2mLintramuscular; intravenousCardinal Health1955-04-27Not applicableUs
Solu-cortefinjection, powder, for solution100 mg/2mLintramuscular; intravascularCardinal Health1955-04-27Not applicableUs
Solu-cortefinjection, powder, for solution100 mg/2mLintramuscular; intravenousPharmacia And Upjohn Company Llc1955-04-27Not applicableUs
Solu-cortefinjection, powder, for solution500 mg/4mLintramuscular; intravenousPharmacia And Upjohn Company Llc1955-04-27Not applicableUs
Solu-cortefinjection, powder, for solution250 mg/2mLintramuscular; intravenousPharmacia And Upjohn Company Llc1955-04-27Not applicableUs
Solu-cortef 1 Gm Act-O-vialpowder for solution1 gintramuscular; intravenousPfizer Canada Inc1967-12-31Not applicableCanada
Solu-cortef 100 Mg Act-O-vialpowder for solution100 mgintramuscular; intravenousPfizer Canada Inc1958-12-31Not applicableCanada
Solu-cortef 250 Mg Act-O-vialpowder for solution250 mgintramuscular; intravenousPfizer Canada Inc1962-12-31Not applicableCanada
Solu-cortef 500 Mg Act-O-vialpowder for solution500 mgintramuscular; intravenousPfizer Canada Inc1966-12-31Not applicableCanada
Texacort Solution 1%lotion1 %topicalGenderm Corporation1988-12-311998-08-06Canada
Topiderm HC 2%cream2 %topicalPaladin Labs Inc1990-12-31Not applicableCanada
Westcortointment2 mg/gtopicalRanbaxy Laboratories Inc.2008-10-06Not applicableUs
Westcort Crm 0.2%cream0.2 %topicalWestwood Squibb, Division Of Bristol Myers Squibb Canada Inc.1992-12-312006-12-18Canada
Westcort Ont 0.2%ointment0.2 %topicalWestwood Squibb, Division Of Bristol Myers Squibb Canada Inc.1991-12-312009-04-17Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
A-hydrocortinjection, powder, lyophilized, for solution100 mg/2mLintramuscular; intravenousHospira, Inc.2011-05-12Not applicableUs
Ala Scalplotion20 mg/mLtopicalCrown Laboratories1973-02-28Not applicableUs
Alacortcream10 mg/gtopicalCrown Laboratories1973-03-09Not applicableUs
Alacortcream25 mg/gtopicalCrown Laboratories1973-03-09Not applicableUs
Anusol HCcream25 mg/gtopicalSalix Pharmaceuticals, Inc1984-06-06Not applicableUs
Colocortsuspension100 mg/60mLrectalPaddock Laboratories, LLC1999-12-31Not applicableUs
Hydrocortisonecream10 mg/gtopicalActavis Mid Atlantic LLC2002-01-03Not applicableUs
Hydrocortisonetablet5 mg/1oralWest Ward Pharmaceuticals Corp2015-02-23Not applicableUs
Hydrocortisonecream25 mg/gtopicalActavis Mid Atlantic LLC2002-09-30Not applicableUs
Hydrocortisonecream10 mg/gtopicalTaro Pharmaceuticals U.S.A., Inc.2005-04-28Not applicableUs
Hydrocortisonelotion25 mg/mLtopicalPerrigo New York Inc2008-05-23Not applicableUs
Hydrocortisoneointment25 mg/gtopicalPhysicians Total Care, Inc.2007-11-28Not applicableUs
Hydrocortisonetablet20 mg/1oralLineage Therapeutics Inc2007-03-30Not applicableUs
Hydrocortisonecream25 mg/gtopicalPreferred Pharmaceuticals, Inc.2012-01-27Not applicableUs
Hydrocortisonelotion25 mg/mLtopicalPhysicians Total Care, Inc.2008-05-08Not applicableUs
Hydrocortisonetablet5 mg/1oralAmerican Health Packaging2014-06-16Not applicableUs
Hydrocortisonetablet10 mg/1oralAvera Mc Kennan Hospital2015-07-22Not applicableUs
Hydrocortisonelotion25 mg/mLtopicalE.FOUGERA & COMPANY A division of Fougera Pharmaceuticals Inc.2000-07-25Not applicableUs
Hydrocortisonecream10 mg/gtopicalRebel Distributors Corp1976-04-30Not applicableUs
Hydrocortisonelotion25 mg/mLtopicalQualitest Pharmaceuticals2003-07-30Not applicableUs
Hydrocortisonecream25 mg/gtopicalTaro Pharmaceuticals U.S.A., Inc.2005-04-28Not applicableUs
Hydrocortisoneointment25 mg/gtopicalPerrigo New York Inc2006-06-13Not applicableUs
Hydrocortisonetablet10 mg/1oralLineage Therapeutics Inc2007-03-30Not applicableUs
Hydrocortisonetablet10 mg/1oralAmerican Health Packaging2011-04-01Not applicableUs
Hydrocortisonecream25 mg/gtopicalLyne Laboratories, Inc.2010-08-30Not applicableUs
Hydrocortisoneointment25 mg/gtopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.1993-05-28Not applicableUs
Hydrocortisonecream25 mg/gtopicalRebel Distributors Corp1986-12-16Not applicableUs
Hydrocortisonecream25 mg/gtopicalQualitest Pharmaceuticals2004-03-12Not applicableUs
Hydrocortisonecream25 mg/gtopicalPerrigo New York Inc2006-03-31Not applicableUs
Hydrocortisonetablet5 mg/1oralLineage Therapeutics Inc2007-03-30Not applicableUs
Hydrocortisonecream25 mg/gtopicalPreferred Pharmaceuticals, Inc2013-01-14Not applicableUs
Hydrocortisonetablet20 mg/1oralSTAT Rx USA LLC1973-06-18Not applicableUs
Hydrocortisonetablet20 mg/1oralQualitest Pharmaceuticals2007-07-16Not applicableUs
Hydrocortisonetablet20 mg/1oralPd Rx Pharmaceuticals, Inc.1973-06-18Not applicableUs
Hydrocortisoneointment25 mg/gtopicalREMEDYREPACK INC.2013-12-17Not applicableUs
Hydrocortisonecream10 mg/gtopicalCrown Laboratories1973-03-09Not applicableUs
Hydrocortisonecream25 mg/gtopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.1986-12-16Not applicableUs
Hydrocortisonecream25 mg/gtopicalSTAT Rx USA LLC2004-03-12Not applicableUs
Hydrocortisonetablet10 mg/1oralQualitest Pharmaceuticals2007-07-16Not applicableUs
Hydrocortisonecream25 mg/gtopicalUnit Dose Services2005-04-28Not applicableUs
Hydrocortisonecream10 mg/gtopicalPd Rx Pharmaceuticals, Inc.2010-01-01Not applicableUs
Hydrocortisonecream25 mg/gtopicalPhysicians Total Care, Inc.1995-08-04Not applicableUs
Hydrocortisoneointment25 mg/1topicalREMEDYREPACK INC.2013-04-12Not applicableUs
Hydrocortisonecream25 mg/gtopicalProficient Rx LP2002-09-30Not applicableUs
Hydrocortisonecream25 mg/gtopicalLake Erie Medical DBA Quality Care Products LLC2006-03-31Not applicableUs
Hydrocortisoneointment10 mg/gtopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.1975-04-16Not applicableUs
Hydrocortisonecream25 mg/gtopicalLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-02-06Not applicableUs
Hydrocortisonetablet10 mg/1oralPd Rx Pharmaceuticals, Inc.2007-07-16Not applicableUs
Hydrocortisonetablet20 mg/1oralPhysicians Total Care, Inc.2007-07-05Not applicableUs
Hydrocortisonecream25 mg/gtopicalREMEDYREPACK INC.2013-06-12Not applicableUs
Hydrocortisonecream25 mg/gtopicalDIRECT RX2014-01-01Not applicableUs
Hydrocortisonecream25 mg/gtopicalANI Pharmaceuticals, Inc.2016-04-01Not applicableUs
Hydrocortisonecream25 mg/gtopicalREMEDYREPACK INC.2016-02-09Not applicableUs
Hydrocortisonecream10 mg/gtopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.1976-04-30Not applicableUs
Hydrocortisonecream10 mg/gtopicalSTAT Rx USA LLC2002-01-03Not applicableUs
Hydrocortisonetablet5 mg/1oralQualitest Pharmaceuticals2007-07-16Not applicableUs
Hydrocortisonetablet5 mg/1oralCarilion Materials Management2007-07-16Not applicableUs
Hydrocortisonecream10 mg/gtopicalANI Pharmaceuticals, Inc.2016-04-01Not applicableUs
Hydrocortisonetablet10 mg/1oralKAISER FOUNDATION HOSPITALS2010-03-05Not applicableUs
Hydrocortisonetablet20 mg/1oralWest Ward Pharmaceuticals Corp1973-06-18Not applicableUs
Hydrocortisonecream10 mg/gtopicalLake Erie Medical DBA Quality Care Products LLC1976-04-30Not applicableUs
Hydrocortisonecream25 mg/gtopicalRebel Distributors Corp2006-03-31Not applicableUs
Hydrocortisonecream25 mg/gtopicalA S Medication Solutions Llc2002-09-30Not applicableUs
Hydrocortisonetablet5 mg/1oralKAISER FOUNDATION HOSPITALS2010-03-05Not applicableUs
Hydrocortisonetablet10 mg/1oralWest Ward Pharmaceuticals Corp2015-02-23Not applicableUs
Hydrocortisonetablet20 mg/1oralMajor Pharmaceuticals1973-06-18Not applicableUs
Hydrocortisoneointment10 mg/gtopicalActavis Mid Atlantic LLC2003-01-03Not applicableUs
Hydrocortisoneointment10 mg/gtopicalCarolina Medical Products Company1985-07-30Not applicableUs
Hydrocortisonecream25 mg/gtopicalAidarex Pharmaceuticals LLC2005-04-28Not applicableUs
Hydrocortisonecream25 mg/gtopicalA S Medication Solutions Llc1986-12-16Not applicableUs
Hydrocortisonetablet20 mg/1oralCarilion Materials Management2007-03-30Not applicableUs
Hydrocortisonetablet20 mg/1oralGolden State Medical Supply, Inc.1973-06-18Not applicableUs
Hydrocortisonetablet20 mg/1oralAmerican Health Packaging2015-03-01Not applicableUs
Hydrocortisone Butyratesolution1 mg/mLtopicalTaro Pharmaceuticals U.S.A., Inc.2004-01-14Not applicableUs
Hydrocortisone Butyratecream1 mg/gtopicalGlenmark Pharmaceuticals Inc., Usa2013-12-05Not applicableUs
Hydrocortisone Butyrateointment1 mg/gtopicalTaro Pharmaceuticals U.S.A., Inc.2004-12-27Not applicableUs
Hydrocortisone Butyratecream1 mg/gtopicalTaro Pharmaceuticals U.S.A., Inc.2005-08-04Not applicableUs
Hydrocortisone Valeratecream2 mg/gtopicalRebel Distributors Corp1998-08-25Not applicableUs
Hydrocortisone Valeratecream2 mg/gtopicalG&W Laboratories, Inc.1998-08-25Not applicableUs
Hydrocortisone Valerateointment2 mg/gtopicalPhysicians Total Care, Inc.2005-03-15Not applicableUs
Hydrocortisone Valerateointment2 mg/gtopicalTaro Pharmaceuticals U.S.A., Inc.1998-08-25Not applicableUs
Hydrocortisone Valeratecream2 mg/gtopicalPhysicians Total Care, Inc.2002-02-04Not applicableUs
Hydrocortisone Valeratecream2 mg/gtopicalPerrigo New York Inc2009-12-02Not applicableUs
Hydrocortisone Valeratecream2 mg/gtopicalTaro Pharmaceuticals U.S.A., Inc.1998-08-25Not applicableUs
Hydrocortisone Valeratecream2 mg/gtopicalDIRECT RX2014-01-01Not applicableUs
Hydrocortisone Valerateointment2 mg/gtopicalG&W Laboratories, Inc.1998-08-25Not applicableUs
Pediaderm HCkitArbor Pharmaceuticals, Inc.2009-11-02Not applicableUs
Procto-pakcream10 mg/gtopicalRising Pharmaceuticals, Inc.2012-06-01Not applicableUs
Proctocortcream10 mg/gtopicalSalix Pharmaceuticals, Inc2004-06-01Not applicableUs
Proctocream HCcream25 mg/gtopicalAlaven Pharmaceutical LLC2011-03-18Not applicableUs
Proctosol-HCcream25 mg/gtopicalPreferred Pharmaceuticals, Inc.2014-11-19Not applicableUs
Proctosol-HCcream25 mg/gtopicalRanbaxy Laboratories Inc2005-04-28Not applicableUs
Proctozonecream25 mg/gtopicalRising Pharmaceuticals, Inc.2015-08-03Not applicableUs
Proctozone HCcream25 mg/gtopicalPreferred Pharmaceuticals, Inc.2012-08-21Not applicableUs
Proctozone HCcream25 mg/gtopicalPhysicians Total Care, Inc.2007-10-30Not applicableUs
Proctozone HCcream25 mg/gtopicalRising Pharmaceuticals, Inc.2012-05-01Not applicableUs
Texacortsolution25 mg/mLtopicalMission Pharmacal Company2011-12-15Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
1 Hydrocortisone Maximum Strengthointment1 g/100gtopicalAmerican Sales Company2012-10-17Not applicableUs
999 Itch Relievingointment1 g/100gtopicalGuangdong CR. Shunfeng Pharmaceutical Co Ltd1989-07-20Not applicableUs
Advanced Hydrocortisonecream10 mg/gtopicalUltra Seal Corporation2011-04-05Not applicableUs
Ana Cool Rapid Soothing Cooling Formulacream10 mg/gtopicalAna Cool, Llc2015-11-25Not applicableUs
Anti Itchcream1 g/100gtopicalHy Vee Inc2015-11-01Not applicableUs
Anti Itchointment1 g/100gtopicalRite Aid Corporation2005-07-25Not applicableUs
Anti Itchcream1 g/100gtopicalRite Aid Corporation2009-02-09Not applicableUs
Anti Itchcream1 g/100gtopicalSafeway2005-08-24Not applicableUs
Anti Itchlotion1 g/100gtopicalWalgreen Company2012-03-27Not applicableUs
Anti Itchcream1 g/100gtopicalRite Aid Corporation2013-09-11Not applicableUs
Anti Itch Maximum Strengthgel1 g/100gtopicalMeijer Distribution Inc1997-09-24Not applicableUs
Anti Itch Maximum Strengthcream1 g/100gtopicalKmart Corporation2010-12-23Not applicableUs
Anti Itch Maximum Strength Pluscream1 g/100gtopicalRite Aid Corporation2011-02-16Not applicableUs
Anti-itchcream10 mg/gtopicalMedline Industries, Inc.2010-03-01Not applicableUs
Anti-itch Scalp Relief Maximum Strengthsolution1 g/100gtopicalDelon Laboratories (1990) Ltd2014-09-08Not applicableUs
Anti-itch Scherer Labsspray1 g/100gtopicalKmart Corporation2013-04-15Not applicableUs
Atopalm Maximum Strength Anti-itchointment1 g/100gtopicalNeo Pharm Co., Ltd.2011-11-04Not applicableUs
Atopalm Moisturizing Hydrocortisonecream1 g/100gtopicalNeo Pharm Co., Ltd.2011-03-17Not applicableUs
Avedana Hydrocortisone Cream With Aloeointment1.02 g/100gtopicalUnipack2016-04-07Not applicableUs
Aveeno Hydrocortisone Anti Itchcream10 mg/gtopicalJohnson & Johnson Consumer Products Company, Division of Johnson & Johnson Consumer Companies, Inc.2012-10-08Not applicableUs
Aveeno Hydrocortisone Anti-itch Creamcream0.5 %topicalJohnson & Johnson Inc2002-05-062005-08-09Canada
Berkley and Jensen Anti Itchcream1 g/100gtopicalBJWC2014-12-09Not applicableUs
Berkley and Jensen Hydrocortisonecream1 g/100gtopicalBJWC2008-12-04Not applicableUs
Biocorneum HC Advanced Scar Supervision Anti-itchgel1 g/100gtopicalEnaltus Inc2012-05-10Not applicableUs
Bioelements Immediate Comfort Hydrocortisonelotion1 mL/100mLtopicalBioelements, Inc.2010-08-19Not applicableUs
Blue-emu Anti-itch Creamcream1 g/100gtopicalNfi Consumer Products2015-06-01Not applicableUs
Budpak Anti-itchcream.01 g/gtopicalBudpak Inc.2012-12-17Not applicableUs
Caldecortcream.284 g/28.4gtopicalInsight Pharmaceuticals2009-07-16Not applicableUs
Care One Hydrocortisone Maximum Strengthcream1 g/100gtopicalAmerican Sales Company2010-11-12Not applicableUs
Care One Hydrocortisone Maximum Strengthcream1 g/100gtopicalAmerican Sales Company2010-05-28Not applicableUs
Careall Hydrocortisone Maximum Strengthcream10 mg/gtopicalNew World Imports, Inc2010-08-30Not applicableUs
Careall Hydrocortisone Maximum Strengthcream1 g/gtopicalNew World Imports, Inc2016-03-11Not applicableUs
Cerave Anti-itchcream10 mg/gtopicalValeant Pharmaceuticals North America LLC2014-12-01Not applicableUs
Cicatricure Ultra Moisturizingcream10 mg/gtopicalGenoma Lab USA Inc2013-12-01Not applicableUs
Cooling Itch Relief Well At Walgreensspray1 g/100gtopicalWalgreens2013-03-15Not applicableUs
Cortacet Crm 0.5%cream0.5 %topicalWhitehall Robins Inc.1992-12-312002-07-19Canada
Cortaid 12-hour Advanced Anti-itchcream1 g/100gtopicalValeant Pharmaceuticals North America LLC2012-10-01Not applicableUs
Cortaid Intensive Therapy Coolingspray10 g/mLtopicalValeant Pharmaceuticals North America LLC2012-10-01Not applicableUs
Cortaid Maximum Strengthcream1 g/100gtopicalValeant Pharmaceuticals North America LLC2012-10-01Not applicableUs
Cortaid Maximum Strengthcream1 g/100gtopicalValeant Pharmaceuticals North America LLC2012-10-01Not applicableUs
Corticreme 0.5%cream0.5 %topicalRougier Pharma Division Of Ratiopharm Inc1988-12-311999-09-27Canada
Cortisil Mdxgel1 g/100gtopicalBio Zone Laboratories,Inc.2013-03-25Not applicableUs
Cortisoneointment1 g/100gtopicalCVS Pharmacy2005-06-10Not applicableUs
Cortisonelotion1 g/100gtopicalCVS Pharmacy2012-04-10Not applicableUs
Cortisone Cream Intensive Healingcream10 mg/gtopicalTai Guk Pharmaceutical Company, Limited2010-01-01Not applicableUs
Cortisone Maximum Strengthcream1 g/100gtopicalCVS Pharmacy2010-01-05Not applicableUs
Cortisone Maximum Strengthcream1 g/100gtopicalCVS Pharmacy2012-02-22Not applicableUs
Cortisone Maximum Strengthgel1 g/100gtopicalCVS Pharmacy2009-12-22Not applicableUs
Cortisone Maximum Strengthointment1 g/100gtopicalCVS Pharmacy2006-04-25Not applicableUs
Cortizone 10ointment10 mg/gtopicalChattem, Inc.2007-09-01Not applicableUs
Cortizone 10cream10 mg/gtopicalChattem, Inc.2007-09-01Not applicableUs
Cortizone 10 Anti-itch for Diabetics Skinlotion1 g/100gtopicalChattem, Inc.2014-12-22Not applicableUs
Cortizone 10 Cooling Cream Anti-itchcream1 g/100gtopicalChattem, Inc.2013-12-02Not applicableUs
Cortizone 10 Cooling Reliefgel10 mg/gtopicalChattem, Inc.2008-10-01Not applicableUs
Cortizone 10 Easy Reliefliquid10 mg/mLtopicalChattem, Inc.2008-10-01Not applicableUs
Cortizone 10 for Psoriasislotion1 g/100gtopicalChattem, Inc.2016-01-15Not applicableUs
Cortizone 10 Hydratensive Healing Anti Itchlotion1 g/100gtopicalChattem, Inc.2010-06-01Not applicableUs
Cortizone 10 Hydratensive Soothing Anti Itchlotion1 g/100gtopicalChattem, Inc.2010-06-01Not applicableUs
Cortizone 10 Intensive Healingcream10 mg/gtopicalChattem, Inc.2007-12-01Not applicableUs
Cortizone 10 Intensive Healing Feminine Itch Reliefcream1 g/100gtopicalChattem, Inc.2014-01-01Not applicableUs
Cortizone 10 Intensive Healing for Eczemalotion10 mg/gtopicalChattem, Inc.2009-12-08Not applicableUs
Cortizone 10 Pluscream10 mg/gtopicalChattem, Inc.2007-09-01Not applicableUs
Cortizone 10 Poison Ivy Relief Padsgel1 g/100gtopicalChattem, Inc.2013-01-20Not applicableUs
Cvs Anti-itch Hydrocortisonecream1 mg/gtopicalCVS Pharmacy, Inc.2014-02-25Not applicableUs
Cvs Cools Itch Fastgel1 mg/gtopicalCVS Pharmacy, Inc.2014-10-13Not applicableUs
Cvs Cortisonecream1 g/100gtopicalCVS Pharmacy1995-08-23Not applicableUs
Cvs Hydrocortisone With Aloecream.5 g/100gtopicalCVS Pharmacy2014-10-13Not applicableUs
Cvs Pharmacy Anti-itchcream1 g/100gtopicalCVS2013-04-30Not applicableUs
Dermacort Anti-itchcream10 mg/gtopicalMelaleuca, Inc.2000-08-02Not applicableUs
Dermaquest Skin Therapy Post-skin Resurfacing Balmcream10 mg/mLtopicalAllure Labs, Inc.2010-01-01Not applicableUs
Dermarest Dricort 0.5% Hydrocortisone Anti-itchcream0.5 %topicalDel Pharmaceutics (Canada) Inc.1995-06-012008-12-16Canada
Dermarest Eczema Medicatedlotion1.18 mL/118mLtopicalInsight Pharmaceuticals2010-09-20Not applicableUs
Dg Health Hydrocortisonecream1 g/100gtopicalDolgencorp, LLC2011-01-14Not applicableUs
Dg Health Hydrocortisone Cream Maximum Strengthcream1 g/100gtopicalDolgencorp Inc2010-01-30Not applicableUs
Dr. Sheffield Hydrocortisone Anti Itchcream10 mg/gtopicalFaria LLC dba Sheffield Pharmaceuticals2007-07-10Not applicableUs
Duane Readecream.284 g/28.4gtopicalDuane Reade2011-03-21Not applicableUs
Duane Reade Hydrocortisonecream.284 g/28.4gtopicalDuane Reade2011-03-18Not applicableUs
Duane Reade Hydrocortisone Plus 12 Moisturizerscream.284 g/287.4gtopicalDuane Reade2011-03-28Not applicableUs
Eczema Skin Mushatts N9cream1 g/100mLtopicalProduct Quest Mfg2013-04-22Not applicableUs
Equaline Anti Itchcream1 g/100gtopicalSupervalu Inc2010-11-17Not applicableUs
Equaline Anti Itchointment1 g/100gtopicalSupervalu Inc2010-12-03Not applicableUs
Equaline Anti Itch Maximum Strengthcream1 g/100gtopicalSupervalu Inc2011-02-25Not applicableUs
Equaline Anti Itch Maximum Strengthcream1 g/100gtopicalSupervalu Inc2010-10-01Not applicableUs
Equate Hydrocortisonecream1 g/100gtopicalWal Mart Stores Inc2005-06-29Not applicableUs
Equate Hydrocortisonecream1 g/100gtopicalWal Mart Stores Inc2009-01-21Not applicableUs
Equate Hydrocortisoneointment1 g/100gtopicalWal Mart Stores Inc2013-02-21Not applicableUs
Equate Hydrocortisonecream1 g/100gtopicalWal Mart Stores Inc2012-03-13Not applicableUs
Exchange Select Hydrocortisonecream1 g/100gtopicalArmy & Air Force Exchange Service2016-02-26Not applicableUs
Face Values Hydrocortisone With Aloecream1 g/100gtopicalHarmon Stores2012-04-01Not applicableUs
Family Care Hydrocortisoneointment1 g/100gtopicalUNITED EXCHANGE CORP.2014-11-24Not applicableUs
Family Care Hydrocortisonecream1 g/100gtopicalUNITED EXCHANGE CORP.2012-04-01Not applicableUs
Family Wellnesscream1 g/100gtopicalZhejiang Jingwei Pharmaceutical Co., Ltd.2013-03-01Not applicableUs
Family Wellness Hydrocortisoneointment1 g/100gtopicalFamily Dollar Services Inc2012-12-05Not applicableUs
Family Wellness Maximum Strength Hydrocortisonecream1 g/100gtopicalFamily Dollar2013-08-19Not applicableUs
Fixmyskin Healing Balm Fragrance-freeointment10 mg/mLtopicalLovely Skin, Inc.2011-11-17Not applicableUs
Fixmyskin Healing Balm Unflavoredointment1 mL/100mLtopicalLovely Skin, Inc.2011-11-17Not applicableUs
Fixmyskin Healing Balm Vanilla Flavorointment1 mL/100mLtopicalLovely Skin, Inc.2011-11-17Not applicableUs
Fixmyskin Healing Balm Vanilla Fragranceointment1 mL/100mLtopicalLovely Skin, Inc2011-11-172016-03-12Us
Formu Care Anti Itch Maximum Strengthcream1 g/100gtopicalAccess Business Group LLC2009-08-12Not applicableUs
Fulton Street Market Anti Itchcream1 g/100gtopicalAccess Business Group LLC2009-08-12Not applicableUs
Gadaderm Hydrocortisonecream.5 g/100gtopicalGadal Laboratories Inc2013-06-01Not applicableUs
Genuine Hydrocortisonecream1 g/100gtopicalGenuine First Aid, LLC2011-03-29Not applicableUs
Good Neighbor Pharmacy Anti Itchlotion1 g/mLtopicalAmerisource Bergen2005-09-09Not applicableUs
Good Neighbor Pharmacy Hydrocortisoneointment1 g/100gtopicalAmerisource Bergen1989-10-03Not applicableUs
Good Neighbor Pharmacy Hydrocortisone Plus 12 Moisturizerscream1 g/100gtopicalAmerisource Bergen1989-10-03Not applicableUs
Good Neighbor Pharmacy Hydrocortisone With Aloecream1 g/100gtopicalAmerisource Bergen1995-08-23Not applicableUs
Good Neighbor Pharmacy Hydrocortisone With Aloe for Sensitive Skincream.5 g/100gtopicalAmerisource Bergen2001-09-13Not applicableUs
Good Sense Anti Itchcream1 g/100gtopicalL. Perrigo Company2006-02-24Not applicableUs
Good Sense Anti Itchcream1 g/100gtopicalL Perrigo Company2006-03-07Not applicableUs
Grx Hicortsuppository.025 g/2grectalGeritrex Corp2013-11-122016-02-02Us
H-releve Anti-itchcream1 g/100gtopicalPure Source Inc.2013-08-152016-01-07Us
Healerz for Itchescream1 g/100gtopicalWellco Brands LLC2013-02-01Not applicableUs
Health Mart Pharmacy Hydrocortisone Maximum Strength Plus 12 Moisturizerscream1 g/100gtopicalHealth Mart1989-10-03Not applicableUs
Health Mart Pharmacy Hydrocortisone Maximum Strength With Aloecream1 g/100gtopicalHealth Mart1989-10-03Not applicableUs
Healthy Accents Cortisone Maximum Strengthcream1 g/100gtopicalDZA Brands LLC2010-08-25Not applicableUs
Hem-easy Relief Herbal Anti-itch Maximum Itch Reliefcream10 mg/mLtopicalBatool Pharma International, Inc2014-08-27Not applicableUs
Hydro Skinlotion1 g/mLtopicalRugby Laboratories2012-10-29Not applicableUs
Hydrocortisonecream10 mg/gtopicalAcme United Corp2015-11-06Not applicableUs
Hydrocortisonecream1 g/100gtopicalRebel Distributors Corp2011-04-13Not applicableUs
Hydrocortisonecream10 mg/mLtopicalUni Shield2010-07-28Not applicableUs
Hydrocortisonecream10 mg/gtopicalUnifirst First Aid Corporation2013-04-15Not applicableUs
Hydrocortisonecream1 h/100gtopicalNeo Pharm Co., Ltd.2010-09-01Not applicableUs
Hydrocortisonecream1 g/100gtopicalSafeway2015-04-07Not applicableUs
Hydrocortisonecream10 mg/gtopicalFirst Aid Only, Inc2015-06-10Not applicableUs
Hydrocortisonecream1 g/100gtopicalH E B2015-09-11Not applicableUs
Hydrocortisonecream1 g/100gtopicalChoice Laboratories2010-02-02Not applicableUs
Hydrocortisonecream10 mg/gtopicalPreferred Pharmaceuticals, Inc2012-03-12Not applicableUs
Hydrocortisonecream10 mg/gtopicalQualitest Pharmaceuticals2001-10-01Not applicableUs
Hydrocortisonecream10 mg/gtopicalUnifirst First Aid Corporation2013-04-15Not applicableUs
Hydrocortisoneointment1 g/100gtopicalA S Medication Solutions Llc2011-08-18Not applicableUs
Hydrocortisonecream1 g/100gtopicalMorales Distributors Inc2012-09-25Not applicableUs
Hydrocortisonecream10 mg/gtopicalSafetec of America, Inc.2010-12-15Not applicableUs
Hydrocortisonecream1 g/100gtopicalPerrigo New York Inc2011-04-13Not applicableUs
Hydrocortisonecream.5 g/100gtopicalKAISER FOUNDATION HOSPITALS2001-09-13Not applicableUs
Hydrocortisoneointment1 g/100gtopicalTaro Pharmaceuticals U.S.A., Inc.1989-10-03Not applicableUs
Hydrocortisonecream10 mg/gtopicalB8 Sales, Inc.2010-05-01Not applicableUs
Hydrocortisonecream10 mg/gtopicalA S Medication Solutions Llc2001-10-01Not applicableUs
Hydrocortisonecream10 mg/gtopicalCVS Pharmacy2009-05-19Not applicableUs
Hydrocortisonecream1 g/100gtopicalPromex, LLC2013-11-15Not applicableUs
Hydrocortisonecream1 g/100gtopicalH E B2010-09-27Not applicableUs
Hydrocortisonecream1 g/100gtopicalNavarro Discount Pharmacies,LLC2012-08-01Not applicableUs
Hydrocortisonecream10 mg/gtopicalAdvanced First Aid, Inc.2015-04-08Not applicableUs
Hydrocortisoneointment1 g/100gtopicalPreferred Pharmaceuticals, Inc.2014-01-23Not applicableUs
Hydrocortisonelotion1 g/mLtopicalPerrigo New York Inc2011-02-07Not applicableUs
Hydrocortisoneointment10 mg/gtopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.1975-04-06Not applicableUs
Hydrocortisoneointment10 mg/gtopicalMoore Medical LLC2012-07-12Not applicableUs
Hydrocortisoneointment1 g/100gtopicalH E B2010-09-15Not applicableUs
Hydrocortisoneointment1 g/100gtopicalWater Jel Technologies2010-04-30Not applicableUs
Hydrocortisonecream.5 g/100gtopicalProficient Rx LP2001-09-13Not applicableUs
Hydrocortisoneointment10 mg/gtopicalValu Merchandisers, Co.2012-01-30Not applicableUs
Hydrocortisonecream1 g/100gtopicalSion Biotext Medical Ltd2012-07-06Not applicableUs
Hydrocortisonecream1 g/100gtopicalDynarex Corporation2015-12-02Not applicableUs
Hydrocortisonecream10 mg/gtopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.1976-04-30Not applicableUs
Hydrocortisonecream.5 g/100gtopicalTaro Pharmaceuticals U.S.A., Inc.2001-09-13Not applicableUs
Hydrocortisonecream1 g/100gtopicalGalentic Pharma (India) Priva Te Limited2013-08-07Not applicableUs
Hydrocortisoneliquid10 mg/mLtopicalCVS Pharmacy2010-07-16Not applicableUs
Hydrocortisonegel1 g/100gtopicalH E B2010-10-02Not applicableUs
Hydrocortisonecream10 mg/gtopicalValu Merchandisers, Co.2012-02-29Not applicableUs
Hydrocortisonecream1 g/100gtopicalDynarex Corporation2010-02-02Not applicableUs
Hydrocortisoneaerosol, spray1.13 g/113gtopicalWal Mart Stores Inc2015-04-15Not applicableUs
Hydrocortisoneointment1 g/100gtopicalPerrigo New York Inc2011-08-18Not applicableUs
Hydrocortisoneointment10 mg/gtopicalDiscount Drug Mart, Inc.2012-01-30Not applicableUs
Hydrocortisonecream1 g/100gtopicalGenuine First Aid2010-04-23Not applicableUs
Hydrocortisoneointment1 g/100gtopicalProficient Rx LP1989-10-03Not applicableUs
Hydrocortisonecream10 mg/gtopicalValu Merchandisers, Co.2012-01-30Not applicableUs
Hydrocortisonecream1 g/100gtopicalDynarex Corporation2010-02-02Not applicableUs
Hydrocortisoneointment1 g/100gtopicalTrifecta Pharmaceuticals Usa Llc2015-03-10Not applicableUs
Hydrocortisoneointment5 mg/gtopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.1981-01-01Not applicableUs
Hydrocortisonecream1 g/100gtopicalBlossom Pharmaceuticals2014-05-01Not applicableUs
Hydrocortisoneointment1 g/100gtopicalH E B2014-01-18Not applicableUs
Hydrocortisonecream1 g/100gtopicalKareway Product, Inc.2013-12-12Not applicableUs
Hydrocortisonecream10 mg/gtopicalUnifirst First Aid Corporation2013-04-15Not applicableUs
Hydrocortisonecream5 mg/gtopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.1968-01-01Not applicableUs
Hydrocortisonecream10 mg/gtopicalHART Health1990-01-30Not applicableUs
Hydrocortisonecream10 mg/gtopicalDiscount Drug Mart Inc.2015-10-30Not applicableUs
Hydrocortisonecream10 mg/gtopicalProficient Rx LP2001-10-01Not applicableUs
Hydrocortisonecream1 h/100gtopicalKareway Product, Inc.2011-08-10Not applicableUs
Hydrocortisoneointment1 g/100gtopicalNorth Safety Products2013-03-06Not applicableUs
Hydrocortisonecream1 g/100gtopicalDiscount Drug Mart, Inc.2015-10-30Not applicableUs
Hydrocortisone 1 Anti Itchointment1.12 g/100gtopicalCVS Pharmacy2005-06-09Not applicableUs
Hydrocortisone 1 Plus 10cream1 g/100gtopicalRite Aid Corporation2011-02-16Not applicableUs
Hydrocortisone 1%ointment1 g/100gtopicalTrifecta Pharmaceuticals Usa Llc2016-04-09Not applicableUs
Hydrocortisone 1% With Healing Aloecream1 g/100gtopicalTrifecta Pharmaceuticals Usa Llc2015-12-23Not applicableUs
Hydrocortisone Acetatecream10 mg/gtopicalBentlin Products LLC2007-01-24Not applicableUs
Hydrocortisone Acetateointment1 g/100gtopicalGalentic Pharma (India) Private Limited2011-09-06Not applicableUs
Hydrocortisone Acetateointment1 g/100gtopicalKinray Inc.2011-09-06Not applicableUs
Hydrocortisone Acetatecream1 g/100gtopicalKinray Inc.2011-07-29Not applicableUs
Hydrocortisone Acetate Antipruritic (anti-itch)cream1 g/100gtopicalTaro Pharmaceuticals U.S.A., Inc.2001-06-01Not applicableUs
Hydrocortisone Anti Itchcream1 g/100gtopicalH E B2010-09-15Not applicableUs
Hydrocortisone Anti-itchcream.01 g/gtopicalUniversal Distribution Center LLC2015-04-15Not applicableUs
Hydrocortisone Anti-itch Pluscream10 mg/gtopicalWal Mart Stores, Inc.2010-06-01Not applicableUs
Hydrocortisone Cream 0.5%cream500 mgtopicalD.C. Labs Limited1982-12-312005-07-19Canada
Hydrocortisone Cream 0.5%cream5 mgtopicalTechnilab Pharma Inc.1996-12-312005-08-05Canada
Hydrocortisone Cream 0.5% USPcream0.5 %topicalPharmetics (2011) Inc1976-12-312000-08-21Canada
Hydrocortisone Cream USP 0.5%cream0.5 %topicalKsl Pharmaceuticals1994-12-311996-09-09Canada
Hydrocortisone Crm 0.5%cream5 mgtopicalStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1965-12-312002-07-31Canada
Hydrocortisone Dcream1 g/100gtopicalNex Med (Usa), Inc.2011-08-19Not applicableUs
Hydrocortisone HCcream1 g/100gtopicalNeopharm Co,. Ltd2010-12-15Not applicableUs
Hydrocortisone Intensive Healing Formulacream1 g/100gtopicalWestern Family Foods Inc2009-03-11Not applicableUs
Hydrocortisone Maximum Strengthcream1 g/100gtopicalChain Drug Consortium, LLC2006-09-08Not applicableUs
Hydrocortisone Maximum Strengthointment1 g/100gtopicalActavis Pharma, Inc.1998-09-01Not applicableUs
Hydrocortisone Maximum Strengthcream1 g/100gtopicalWalgreen Company1990-01-01Not applicableUs
Hydrocortisone Maximum Strengthcream1 g/100gtopicalSelect Brand2006-02-01Not applicableUs
Hydrocortisone Maximum Strengthcream1 g/100gtopicalArmy and Air Force Exchange Service2005-03-14Not applicableUs
Hydrocortisone Maximum Strengthointment1 g/100gtopicalWalgreen Company1990-01-01Not applicableUs
Hydrocortisone Maximum Strengthcream1 g/100gtopicalWalgreen Company2010-07-16Not applicableUs
Hydrocortisone Maximum Strengthointment1 g/100gtopicalStephen L. La France Pharmacy, Inc.2008-05-13Not applicableUs
Hydrocortisone Maximum Strengthcream1 g/100gtopicalPreferred Pharmaceuticals, Inc.2012-04-30Not applicableUs
Hydrocortisone Maximum Strengthcream1 g/100gtopicalActavis Pharma, Inc.1997-08-01Not applicableUs
Hydrocortisone Maximum Strengthcream1 g/100gtopicalFREDS, INC2009-09-01Not applicableUs
Hydrocortisone Maximum Strengthcream1 g/100gtopicalKroger Company2008-07-24Not applicableUs
Hydrocortisone Maximum Strengthcream1 g/100gtopicalH E B2010-08-23Not applicableUs
Hydrocortisone Maximum Strengthointment1 g/100gtopicalChain Drug Consortium, LLC2006-09-08Not applicableUs
Hydrocortisone Maximum Strengthcream1 g/100gtopicalWalgreen Company2009-02-27Not applicableUs
Hydrocortisone Maximum Strengthointment1 g/100gtopicalWalgreen Company2010-07-16Not applicableUs
Hydrocortisone Maximum Strength Plus 12 Moisturizerscream1 g/100gtopicalFred's Inc.2009-05-01Not applicableUs
Hydrocortisone Maximum Strength Plus 12 Moisturizerscream1 g/100gtopicalStephen L. La France Pharmacy, Inc.2010-04-05Not applicableUs
Hydrocortisone Maximum Strength With Aloecream1 g/100gtopicalFamily Dollar Services Inc.2007-03-22Not applicableUs
Hydrocortisone Maximum Strength With Aloecream1 g/100gtopicalChain Drug Marketing Association Inc.2010-07-01Not applicableUs
Hydrocortisone Maximum Strength With Aloecream1 g/100gtopicalStephen L. La France Pharmacy, Inc.2005-09-23Not applicableUs
Hydrocortisone Maximum Strength With Aloecream1 g/100gtopicalChain Drug Marketing Association Inc.2010-07-01Not applicableUs
Hydrocortisone Maximum Strength With Aloecream1 g/100gtopicalProficient Rx LP2009-04-21Not applicableUs
Hydrocortisone Ointment 0.5%ointment0.5 %topicalD.C. Labs Limited1968-12-312003-07-11Canada
Hydrocortisone Pluscream10 mg/gtopicalWalgreens2010-06-01Not applicableUs
Hydrocortisone Plus 10 Moisturizerscream1 g/100gtopicalWalgreen Company2015-08-27Not applicableUs
Hydrocortisone Plus 12 Moisturizerscream1 g/100gtopicalTaro Pharmaceuticals U.S.A., Inc.1989-10-03Not applicableUs
Hydrocortisone Plus 12 Moisturizers Maximum Strengthcream1 g/100gtopicalKroger Company2008-07-01Not applicableUs
Hydrocortisone Regular Strengthcream.5 g/100gtopicalWalgreen Company1997-01-07Not applicableUs
Hydrocortisone Ultra Strengthcream140 mg/14gtopicalPersonal Care Products, Inc.2013-07-10Not applicableUs
Hydrocortisone With Aloecream1 g/100gtopicalMeijer Distribution Inc1995-08-23Not applicableUs
Hydrocortisone With Aloecream1 g/100gtopicalTaro Phamaceuticals U.S.A., Inc.1995-08-23Not applicableUs
Hydrocortisone With Aloecream1 g/100gtopicalProficient Rx LP1995-08-23Not applicableUs
Hydrocortisone With Aloe Maximum Strengthcream1 g/100gtopicalMajor Pharmaceuticals2009-04-21Not applicableUs
Hydrocortisone With Aloe Maximum Strengthcream1 g/100gtopicalActavis Pharma, Inc.1998-07-08Not applicableUs
Hydroskincream1 g/100gtopicalRugby Laboratories2012-10-29Not applicableUs
Hydroskinlotion1 g/100mLtopicalRugby Laboratories2015-08-25Not applicableUs
Immediate Comfort Bioelementslotion1 g/88mLtopicalBioelements, Inc.2012-08-23Not applicableUs
Instant Cooling Itch Relief Cvsspray1 g/100gtopicalCVS2014-11-11Not applicableUs
Intensive Healing Anti Itchcream1 g/100gtopicalRite Aid Corporation2014-03-20Not applicableUs
Irritated Skin Treatmentcream0.5 %topicalAvon Canada Ulc2005-07-302007-07-26Canada
Itch and Rash Creamcream10 mg/gtopicalProvision Medical Products2015-03-31Not applicableUs
Jamp Hydrocortisone Cream USP 0.5%cream0.5 %topicalJamp Pharma Corporation2006-03-162008-08-28Canada
Kaiser Permanente Hydrocortisoneointment1 g/100gtopicalKAISER FOUNDATION HOSPITALS1989-10-03Not applicableUs
Kaiser Permanente Hydrocortisonecream1 g/100gtopicalKAISER FOUNDATION HOSPITALS2001-06-01Not applicableUs
Kera HC Hydrocortisonecream1 g/100gtopicalClinical Therapeutic Solutions2012-10-17Not applicableUs
Kirkland Signature Hydrocortisone Plus Maximum Strengthcream1 g/100gtopicalCostco Wholesale Company2009-10-02Not applicableUs
Lanacort Crm 0.5%cream.5 %topicalCombe Incorporated1987-12-311998-07-27Canada
Leader Hydrocortisonecream1 g/100gtopicalCardinal Health2012-02-13Not applicableUs
Leader Hydrocortisonecream1 g/100gtopicalREMEDYREPACK INC.2016-02-29Not applicableUs
Leader Hydrocortisone With Aloecream1 g/100gtopicalCardinal Health2012-03-01Not applicableUs
Lincolncream.01 g/gtopicalLincoln Pharmaceuticals Ltd.2013-05-23Not applicableUs
Live Better Hydrocortisone With Aloecream1 g/100gtopicalThe Great Atlantic & Pacific Tea Company1995-08-23Not applicableUs
Loesch Anti-itch Therapyliquid5 mg/mLtopicalLoesch Laboratory Consultants, Inc.2014-06-26Not applicableUs
Loesch HC-10 Anti-itch Therapyliquid9 mg/mLtopicalLoesch Laboratory Consultants, Inc.2015-07-01Not applicableUs
Lucky Supersoft Maximum Strengthcream1 g/100gtopicalDelta Brands, Inc2015-01-31Not applicableUs
Makesense Maximum Strengthcream1 g/100gtopicalCherry Hill Sales Co2014-06-15Not applicableUs
Market Basket Anti-itch Cream Pluscream1 g/100gtopicalDavion, Inc.2016-03-06Not applicableUs
Maximum Strength Cortizone 10 Quick Shot 360 Continuousspray10 mg/mLtopicalChattem, Inc.2012-12-062016-01-20Us
Maximum Strength Hydrocortisoneointment1 g/100gtopicalDLC Laboratories, Inc2013-03-22Not applicableUs
Maximum-Hcream1 g/100gtopicalNew GPC, Inc.2009-12-01Not applicableUs
Medi-cortisone With Aloecream1 g/100gtopicalMedicine Shoppe International Inc1995-08-23Not applicableUs
Medi-firstcream.009 g/1topicalMedique Products2009-10-20Not applicableUs
Medpridecream10 mg/gtopicalShield Line LLC2013-05-23Not applicableUs
Meijer Anti Itchointment1 g/100gtopicalMEIJER, INC.2015-01-15Not applicableUs
Meijer Anti Itch Cream Pluscream1 g/100gtopicalMEIJER, INC.2015-01-15Not applicableUs
Meijer Anti-itch With Aloecream1 g/100gtopicalMEIJER, INC.2015-01-14Not applicableUs
Meijer Hydrocortisonecream1 g/100gtopicalMeijer Distribution Inc1995-08-23Not applicableUs
Meijer Hydrocortisone Plus 12 Moisturizerscream1 g/100gtopicalMeijer Distribution Inc1989-10-03Not applicableUs
Meijer Itch and Rash Reliefointment1 g/100gtopicalMeijer Distribution Inc1989-10-03Not applicableUs
Members Mark Hydrocortisonecream1 g/100gtopicalSam's West Inc2007-07-13Not applicableUs
Monistat Complete Care Instant Itch Reliefcream1 g/100gtopicalInsight Pharmaceuticals2013-11-15Not applicableUs
Natureplex Hydrocortisone Hydrocream.01 g/gtopicalNatureplex, LLC2008-01-22Not applicableUs
Neosporin Eczema Essentials Anti Itchcream10 mg/gtopicalJohnson & Johnson Consumer Products Company, Division of Johnson & Johnson Consumer Companies, Inc.2011-09-30Not applicableUs
Nu-derm Tolereen Anti-pruriticlotion5 mg/gtopicalOMP, INC.1988-01-01Not applicableUs
Our Family Hydrocortisone With Aloecream1 g/100gtopicalNash Finch Company1995-08-23Not applicableUs
Piyanping Antiitchcream1 g/100gtopicalGuangdong Zhanjiang Jimin Pharmaceutical Company, Ltd.2011-04-16Not applicableUs
Poli-Aointment1 g/100gtopicalSato Pharmaceutical Co., Ltd.1995-03-19Not applicableUs
Post Peel Protectant Vitality Institutecream7.5 g/100mLtopicalVi Medical Products Inc.2015-03-25Not applicableUs
Post Peel Protectant Vitality Institutecream7.5 g/100mLtopicalVitality Institute Medical Products2015-03-25Not applicableUs
Post Treatment Balmcream1 mg/gtopicalAllure Labs, Inc2015-05-12Not applicableUs
Premier Value Hydrocortisonecream1 g/100gtopicalChain Drug Consortium1995-08-23Not applicableUs
Premier Value Hydrocortisone Plus 12 Moisturizerscream1 g/100gtopicalChain Drug Consortium1989-10-03Not applicableUs
Preparation H Hydrocortisonecream10 mg/gtopicalPfizer Consumer Healthcare2004-01-01Not applicableUs
Proactiv Solution Anti-itch Scalpliquid.28 mg/100mLtopicalGuthy Renker Llc.2010-10-07Not applicableUs
Procureointment1 g/100gtopicalTWIN MED, LLC2013-02-05Not applicableUs
Psoriasin Itch Controlcream10 mg/gtopicalAlva Amco Pharmacal Companies, Inc.2016-02-22Not applicableUs
Publix Hydrocream1 g/100gtopicalPublix Super Markets Inc1995-08-23Not applicableUs
Publix Hydro Pluscream1 g/100gtopicalPublix Super Markets Inc1989-10-03Not applicableUs
Quadryderncream10 mg/gtopicalProductos Zapotol Corp2013-06-30Not applicableUs
Quality Choice Anti Itch With Aloeointment1 g/100gtopicalChain Drug Marketing Association Inc2015-01-15Not applicableUs
Quality Choice Hydrocortisonecream1 g/100gtopicalChain Drug Marketing Association1995-08-23Not applicableUs
Quality Choice Hydrocortisone Maximum Strengthcream1 g/100gtopicalChain Drug Marketing Association Inc2015-01-15Not applicableUs
Quality Choice Maximum Strength Anti Itchcream1 g/100gtopicalChain Drug Marketing Association Inc2015-01-19Not applicableUs
Rexall Anti Itch Maximum Strength Reliefcream1 g/100gtopicalDolgencorp, LLC2010-08-31Not applicableUs
Rexall Hydrocortisone 1cream1 g/100gtopicalDolgencorp, LLC2011-01-14Not applicableUs
Rexall Hydrocortisone Plus Moisturizerscream1 g/100gtopicalDolgencorp, LLC2011-01-14Not applicableUs
Rite Aid Anti-itchcream1 g/100gtopicalRite Aid Corporation1995-08-23Not applicableUs
Rodan and Fields Soothecream1 mg/100mLtopicalCosmetic Enterprises Ltd.2009-01-01Not applicableUs
Rugby Hydroskincream1 g/100gtopicalRugby Laboratories2015-07-15Not applicableUs
Safeway Hydrocortisone Plus 12 Moisturizerscream1 g/100gtopicalSafeway Inc.1989-10-03Not applicableUs
Scalpicin Anti-itch Maximum Strengthliquid1 g/100mLtopicalReckitt Benckiser LLC2012-10-15Not applicableUs
Scalpicin Maximum Strengthliquid1 g/100mLtopicalReckitt Benckiser LLC2012-01-16Not applicableUs
Scalpicin Scalp Itch Medication Maximum Strengthliquid10 mg/gtopicalCombe Incorporated1992-12-15Not applicableUs
Schein Hydrocortisonecream10 mg/gtopicalHenry Schein, Inc.2011-04-05Not applicableUs
Selsun Blue Scalp Itch Treatmentliquid1 g/100mLtopicalChattem, Inc.2013-10-01Not applicableUs
Shopko Hydrocortisonecream1 g/100gtopicalUNITED EXCHANGE CORP.2011-02-08Not applicableUs
Shopko Hydrocortisoneointment1 g/100gtopicalShopko Stores Operating Co., LLC1989-10-03Not applicableUs
Shopko Hydrocortisone Intensive Healing Formulacream1 g/100gtopicalShopko Stores Operating Co., LLC1995-08-23Not applicableUs
Shopko Hydrocortisone Maximum Strengthcream1 g/100gtopicalShopko Stores Operating Co., LLC1995-08-23Not applicableUs
Shopko Hydrocortisone Plus 12 Moisturizers Maximum Strengthcream1 g/100gtopicalShopko Stores Operating Co., LLC1989-10-03Not applicableUs
Shopko Hydrocortisone With Aloecream1 g/100gtopicalUnited Exchange Corp2012-12-31Not applicableUs
Shopko Maximum Strengthcream1 g/100gtopicalShopko Stores Operating Co., LLC1995-08-23Not applicableUs
Shoprite Hydrocortisonecream1 g/100gtopicalWakefern Food Corporation2013-12-12Not applicableUs
Signature Care Anti Itchcream1 g/100gtopicalSafeway2015-10-14Not applicableUs
Signature Care Hydrocortisonecream1 g/100gtopicalSafeway2015-11-10Not applicableUs
Signature Care Hydrocortisonecream1 g/100gtopicalSafeway2015-10-24Not applicableUs
Signature Care Hydrocortisonecream1 g/100gtopicalSafeway2015-11-11Not applicableUs
Smart Sense Anti Itchcream1 g/100gtopicalKmart Corporation2010-09-27Not applicableUs
Smart Sense Anti Itchcream1 g/100gtopicalKmart Corporation2015-12-09Not applicableUs
Smart Sense Anti Itch Maximum Strengthcream1 g/100gtopicalKmart Corporation2011-03-31Not applicableUs
Smart Sense Anti Itch Maximum Strengthointment1 g/100gtopicalKmart Corporation2010-11-16Not applicableUs
Smart Sense Hydrocortisonecream1 g/100gtopicalKmart Corporation2015-07-08Not applicableUs
Smart Sense Hydrocortisonecream1 g/100gtopicalKmart Corporation2013-12-17Not applicableUs
Smart Sense Hydrocortisonecream1 g/100gtopicalKmart Corporation2010-09-27Not applicableUs
Smart Sense Hydrocortisoneointment1 g/100gtopicalKmart Corporation2015-07-08Not applicableUs
Smart Sense Hydrocortisonecream1 g/100gtopicalKmart Corporation2014-02-27Not applicableUs
Soothe Rodan Fieldslotion1 mL/100mLtopicalRodan & Fields, LLC.2011-06-07Not applicableUs
Sunmark Hydrocortisoneointment1 g/100gtopicalMc Kesson1989-10-03Not applicableUs
Sunmark Hydrocortisone Plus 12 Moisturizerscream1 g/100gtopicalMc Kesson1989-10-03Not applicableUs
Sunmark Hydrocortisone With Aloe Maximum Strengthcream1 g/100gtopicalMc Kesson1995-08-23Not applicableUs
Tecnu Corticoolgel10 mg/gtopicalTec Laboratories, Inc.1999-06-23Not applicableUs
Thera Pluscream1 g/100gtopicalZhejiang Jingwei Pharmaceutical Co., Ltd.2013-03-01Not applicableUs
Topcare Hydrocortisoneointment1 g/100gtopicalTopco Associates LLC1989-10-03Not applicableUs
Topcare Hydrocortisone 1% With Aloecream1 g/100gtopicalTopco Associates LLC1995-08-23Not applicableUs
Topcare Hydrocortisone Intensive Healing Formulacream1 g/100gtopicalTopco Associates LLC1995-08-23Not applicableUs
Topcare Hydrocortisone Plus 12 Moisturizerscream1 g/100gtopicalTopco Associates LLC1989-10-03Not applicableUs
Truelipids Anti-itch Barriercream1 g/100mLtopicalDerm Deal, Llc Dba Cheryl Lee, Md Sensitive Skin Care2014-03-01Not applicableUs
Up and Up Anti Itchcream1 g/100gtopicalTarget Corporation2013-03-18Not applicableUs
Up and Up Anti Itchlotion1 g/100gtopicalTarget Corporation2013-06-12Not applicableUs
Up and Up Anti Itchcream1 g/100gtopicalTarget Corporation2011-03-17Not applicableUs
Up and Up Anti Itchcream1 g/100gtopicalTarget Corporation2009-11-09Not applicableUs
Up and Up Anti Itch Maximum Strengthointment1 g/100gtopicalTarget Corporation2009-10-09Not applicableUs
Up and Up Hydrocortisonecream1 g/100gtopicalTarget Corporation2015-04-07Not applicableUs
Up and Up Hydrocortisoneointment1 g/100gtopicalTarget Corporation2015-04-16Not applicableUs
Up and Up Hydrocortisonecream1 g/100gtopicalTarget Corporation2015-04-01Not applicableUs
Up and Up Hydrocortisone One Per Centcream1 g/100gtopicalTarget Corporation2015-04-09Not applicableUs
Vagisil Anti-itch Creme Maximum Strength Sensitive Skin Formulacream280 mg/28gtopicalCombe Incorporated2016-01-30Not applicableUs
Vagisil Satincream10 mg/gtopicalCombe Incorporated2008-04-15Not applicableUs
Vanicream HC Anti-itchcream1.12 g/100gtopicalPharmaceutical Specialties, Inc.2016-01-26Not applicableUs
Walgreens Hydrocortisone Plus 12 Moisturizerscream1 g/100gtopicalWalgreen Company1989-10-03Not applicableUs
Western Family Hydrocortisonecream1 g/100gtopicalWestern Family Foods Inc1995-08-23Not applicableUs
Western Family Hydrocortisone Plus 12 Moisturizerscream1 g/100gtopicalWestern Family Foods Inc1989-10-03Not applicableUs
Winco Maximum Strength Hydrocortisonecream1 g/100gtopicalWin Co Foods, Llc2015-02-16Not applicableUs
Winco Maximum Strength Hydrocortisonecream1 g/100gtopicalWin Co Foods, Llc2015-02-16Not applicableUs
Yes To Coconut Eczema Reliefcream10 mg/mLtopicalYes To Incorporated2015-06-09Not applicableUs
Zims Advanced Crack Creme With Hydrocortisonecream10 mg/LtopicalNATURAL ESSENTIALS, INC.2014-01-01Not applicableUs
Zims Advanced Hydrocortisone Continuous With Organic Arnica and Aloespray10 g/LtopicalNATURAL ESSENTIALS, INC.2014-01-01Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Anucort-HCsuppository25 mg/1rectalPreferred Pharmaceuticals, Inc2012-03-12Not applicableUs
Anucort-HCsuppository25 mg/1rectalG&W Laboratories, Inc.1990-01-15Not applicableUs
Anusol HCsuppository25 mg/1rectalSalix Pharmaceuticals, Inc2004-06-01Not applicableUs
Grx Hicortsuppository25 mg/2grectalGeritrex Corp2015-07-012016-01-01Us
Hemmorex-HCsuppository30 mg/1rectalLaser Pharmaceuticals, LLC2013-11-12Not applicableUs
Hemmorex-HCsuppository25 mg/1rectalLaser Pharmaceuticals, LLC2013-11-12Not applicableUs
Hydrocortisone Acetatesuppository25 mg/1rectalPaddock Laboratories, LLC1990-07-01Not applicableUs
Hydrocortisone Acetatesuppository25 mg/1rectalA S Medication Solutions Llc1990-07-01Not applicableUs
Hydrocortisone Acetatesuppository30 mg/1rectalRebel Distributors Corp2004-06-01Not applicableUs
Hydrocortisone Acetatesuppository25 mg/1rectalPreferred Pharmaceuticals, Inc.2013-08-16Not applicableUs
Hydrocortisone Acetatesuppository25 mg/1rectalAscend Laboratories, LLC2013-10-012016-03-01Us
Hydrocortisone Acetatesuppository30 mg/1rectalPaddock Laboratories, LLC2003-07-07Not applicableUs
Nucortlotion20 mg/gtopicalGentex Pharma2010-08-16Not applicableUs
Proctocortsuppository30 mg/1rectalSalix Pharmaceuticals, Inc2004-06-01Not applicableUs
Rectacort - HCsuppository25 mg/1rectalAcino Products, Llc.2006-11-01Not applicableUs
International Brands
NameCompany
ActicortNot Available
Aeroseb HCNot Available
Ala-ScalpNot Available
AlgicirtisNot Available
Aquanil HCNot Available
Beta-HCNot Available
CetacortNot Available
CortaidNot Available
DelacortNot Available
FicortrilNot Available
GenacortNot Available
GlycortNot Available
Komed HCNot Available
Lacticare HCNot Available
LubricortNot Available
MedicortNot Available
MeusicortNot Available
Micort-HCNot Available
MildisonNot Available
Nogenic HCNot Available
NutracortNot Available
Nystaform-HCNot Available
OtocortNot Available
PenecortNot Available
PermicortNot Available
Polcort HNot Available
Preparation H Hydrocortisone CreamNot Available
PrepcortNot Available
Prevex HCNot Available
ProctocortNot Available
ProctocreamNot Available
ProtocortNot Available
Remederm HCNot Available
SanatisonNot Available
Scalpicin CapilarNot Available
SchericurNot Available
SigmacortNot Available
SynacortNot Available
Systral HydrocortNot Available
TimocortNot Available
Brand mixtures
NameLabellerIngredients
Acella Hydrocortisone Acetate - Pramoxine SinglesAcella Pharmaceuticals, LLC
Acetasol HCActavis Mid Atlantic LLC
Ala QuinCrown Laboratories
AlcortinPrimus Pharmaceuticals
AlocaneQuest Products, Inc.
Ana-lexAvion Pharmaceuticals, Llc
Analpram AdvancedFerndale Laboratories, Inc.
Analpram EFerndale Laboratories, Inc.
Analpram E Cream 2.5% Kit Hydrocortisone Acetate 2.5% Pramoxine Hydrochloride 1%Sebela Pharmaceuticals Inc.
Analpram HCFerndale Laboratories, Inc.
Anodan-HC 10mg SuppositoriesOdan Laboratories Ltd
Anodan-HC OintmentOdan Laboratories Ltd
Antibiotic Ear (neo/polym/hc)Physicians Total Care, Inc.
Anugesic-HC OintmentMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Anugesic-HC SuppositoriesMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Anusol-HC OintmentMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Anusol-HC SuppositoriesMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Calmurid HC CrmGalderma Canada Inc
Cipro HCAlcon Laboratories, Inc.
Cipro HC Otic SuspensionAlcon Canada Inc
Coly-mycin SPar Pharmaceutical, Inc.
CortisporinPhysicians Total Care, Inc.
Cortisporin-TCPar Pharmaceutical, Inc.
CortomycinMajor Pharmaceuticals
DermazeneStratus Pharamceuticals, Inc
Dermoscribe IchybumXlma Pty Ltd
Dermoscribe Seborrheic DermatitisDermoscribe Pty Ltd
Dr. Throwers HydrotetDr. Thrower's Skincare, Inc.
Egozinc-HCPharmascience Inc
EpifoamMEDA Pharmaceuticals
First Dukes Mouthwash CompoundingCutis Pharma, Inc.
First Marys Mouthwash CompoundingCutis Pharma, Inc.
Fucidin HLeo Pharma Inc
Hydrocortisone Acetate and Pramoxine HydrochlorideAcella Pharmaceuticals, LLC
Hydrocortisone Acetate Pramoxine HClPerrigo New York Inc
Hydrocortisone Acetate, IodoquinolBowyn Labs, Llc
Hydrocortisone and Acetic AcidQualitest Pharmaceuticals
Hydrocortisone IodoquinolPerrigo New York Inc
Jampzinc-HCJamp Pharma Corporation
Lidocaine HCl - Hydrocortisone AcetatePure Tek Corporation
Lidocaine HCl - Hydrocortisone Acetate With AloePure Tek Corporation
Lidocaine HCl and Hydrocortisone AcetateAcella Pharmaceuticals, LLC
Lidocaine Hydrochloride and Hydrocortisone AcetateSeton Pharmaceuticals
Neo Polycin HCPaddock Laboratories, LLC
Neo-cortef 0.5% OintmentPfizer Canada Inc
Neo-cortef 1% OintmentPfizer Canada Inc
Neo-cortef Eye Ear Drops Sterile SuspensionPharmacia & Upjohn Inc
Neo-poly-bac HydroButler Animal Health Supply
Neo-polycin HCFera Pharmaceuticals
Neomycin and Polymyxin B Sulfates and Bacitracin Zinc With Hydrocortisone AcetateRebel Distributors Corp
Neomycin and Polymyxin B Sulfates and HydrocortisoneBlenheim Pharmacal, Inc
Neomycin and Polymyxin B Sulfates, Bacitracin Zinc and HydrocortisoneMwi/Vet One
Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and HydrocortisoneHenry Schein Inc.
Neomycin, Polymyxin B Sulfates and HydrocortisonePhysicians Total Care, Inc.
NovacortNovum Pharma, Llc
Odan-spor-HCOdan Laboratories Ltd
Ophthocort OntParke Davis Division, Warner Lambert Canada Inc.
Otizol HC LiqLab Nadeau LtÉe, Division Of Technilab Inc.
Pentamycetin/hcSandoz Canada Incorporated
Poison OakDe Martini Spring Hill Pharmacy, Inc.
PramcortRochester Pharmaceuticals
PramosoneFerndale Laboratories, Inc.
Pramosone CreamSebela Pharmaceuticals Inc.
Pramosone EFerndale Laboratories, Inc.
Pramosone E Cream 2.5% Hydrocortisone Acetate 2.5% Pramoxine Hydrochloride 1%Sebela Pharmaceuticals Inc.
Pramox HC CreamDermtek Pharma Inc
Pramox HC LotionDermtek Pharma Inc
Pramoxine-HCAscend Laboratories, LLC
ProcortWomens Choice Pharmaceuticals LLC
Proctodan-HC OintmentOdan Laboratories Ltd
Proctodan-HC SuppositoriesOdan Laboratories Ltd
Proctofoam HCMEDA Pharmaceuticals
Ratio-hemcort-HCTeva Canada Limited
Rectogel HCLaboratoire Riva Inc
Riva-sol HC OintmentLaboratoire Riva Inc
Rivasol-HC SuppositoriesLaboratoire Riva Inc
Sandoz Anuzinc HCSandoz Canada Incorporated
Sandoz Anuzinc HC PlusSandoz Canada Incorporated
Sandoz Anuzinc HC Plus SuppositoriesSandoz Canada Incorporated
Sandoz Anuzinc HC SuppositoriesSandoz Canada Incorporated
Sandoz CortimyxinSandoz Canada Incorporated
Scarguard MdScarguard Labs, Llc
Scarguard Md Physicians FormulaScarguard Labs, Llc
Sopamycetin/hc OintmentLaboratoires Charton Laboratories
Sopamycetin/hc OntLaboratoires Charton Laboratories
Sopamycetin/hc SuspLaboratoires Charton Laboratories
Sterex Crm PlusInternational Dermatologicals Inc.
Sterex Lot PlusInternational Dermatologicals Inc.
Ti-U-lac HC LotionMerit Industries Inc.
Triple Antibiotic HCPhoenix Pharmaceutical, Inc.
Uremol HCGlaxosmithkline Inc
Vanoxide HCSummers Laboratories Inc
Vioform + HydrocortisoneCiba Pharmaceuticals, Ciba Geigy Canada Ltd.
Vioform HydrocortisonePaladin Labs Inc
Vioform Hydrocortisone MildNovartis Pharmaceuticals Canada Inc
Vosol HCECR Pharmaceuticals Co., Inc.
VytoneArtesa Labs, Llc
XereseValeant Pharmaceuticals North America LLC
Salts
Name/CASStructureProperties
Hydrocortisone aceponate
74050-20-7
Thumb
  • InChI Key: MFBMYAOAMQLLPK-FZNHGJLXSA-N
  • Monoisotopic Mass: 460.246103499
  • Average Mass: 460.567
DBSALT001278
Hydrocortisone acetate
Thumb
  • InChI Key: ALEXXDVDDISNDU-JZYPGELDSA-N
  • Monoisotopic Mass: 404.219888756
  • Average Mass: 404.4966
DBSALT000369
Hydrocortisone butyrate
ThumbNot applicableDBSALT001234
Hydrocortisone cypionate
ThumbNot applicableDBSALT001388
Hydrocortisone probutate
Thumb
  • InChI Key: FOGXJPFPZOHSQS-AYVLZSQQSA-N
  • Monoisotopic Mass: 488.277403634
  • Average Mass: 488.613
DBSALT000783
Hydrocortisone sodium phosphate
ThumbNot applicableDBSALT001379
Hydrocortisone sodium succinate
ThumbNot applicableDBSALT001297
Hydrocortisone valerate
57524-89-7
Thumb
  • InChI Key: FZCHYNWYXKICIO-FZNHGJLXSA-N
  • Monoisotopic Mass: 446.266838948
  • Average Mass: 446.5763
DBSALT000782
Categories
UNIIWI4X0X7BPJ
CAS number50-23-7
WeightAverage: 362.4599
Monoisotopic: 362.20932407
Chemical FormulaC21H30O5
InChI KeyInChIKey=JYGXADMDTFJGBT-VWUMJDOOSA-N
InChI
InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
IUPAC Name
(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one
SMILES
[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[[email protected]](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassHydroxysteroids
Direct Parent21-hydroxysteroids
Alternative Parents
Substituents
  • 21-hydroxysteroid
  • Progestogin-skeleton
  • Pregnane-skeleton
  • 20-oxosteroid
  • 17-hydroxysteroid
  • 11-hydroxysteroid
  • 11-beta-hydroxysteroid
  • Oxosteroid
  • 3-oxosteroid
  • 3-oxo-delta-4-steroid
  • Delta-4-steroid
  • Tertiary alcohol
  • Cyclic alcohol
  • Alpha-hydroxy ketone
  • Cyclic ketone
  • Secondary alcohol
  • Ketone
  • Hydrocarbon derivative
  • Primary alcohol
  • Organooxygen compound
  • Carbonyl group
  • Alcohol
  • Aliphatic homopolycyclic compound
Molecular FrameworkAliphatic homopolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.
PharmacodynamicsHydrocortisone is the most important human glucocorticoid. It is essential for life and regulates or supports a variety of important cardiovascular, metabolic, immunologic and homeostatic functions. Topical hydrocortisone is used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by having different receptors, target cells, and effects. Technically, the term corticosteroid refers to both glucocorticoids and mineralocorticoids, but is often used as a synonym for glucocorticoid. Glucocorticoids suppress cell-mediated immunity. They act by inhibiting genes that code for the cytokines IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 and TNF-alpha, the most important of which is the IL-2. Reduced cytokine production limits T cell proliferation. Glucocorticoids also suppress humoral immunity, causing B cells to express lower amounts of IL-2 and IL-2 receptors. This diminishes both B cell clonal expansion and antibody synthesis. The diminished amounts of IL-2 also leads to fewer T lymphocyte cells being activated.
Mechanism of actionHydrocortisone binds to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes. The anti-inflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. Specifically glucocorticoids induce lipocortin-1 (annexin-1) synthesis, which then binds to cell membranes preventing the phospholipase A2 from coming into contact with its substrate arachidonic acid. This leads to diminished eicosanoid production. The cyclooxygenase (both COX-1 and COX-2) expression is also suppressed, potentiating the effect. In other words, the two main products in inflammation Prostaglandins and Leukotrienes are inhibited by the action of Glucocorticoids. Glucocorticoids also stimulate the lipocortin-1 escaping to the extracellular space, where it binds to the leukocyte membrane receptors and inhibits various inflammatory events: epithelial adhesion, emigration, chemotaxis, phagocytosis, respiratory burst and the release of various inflammatory mediators (lysosomal enzymes, cytokines, tissue plasminogen activator, chemokines etc.) from neutrophils, macrophages and mastocytes. Additionally the immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding.
Related Articles
AbsorptionTopical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption.
Volume of distributionNot Available
Protein binding95%
Metabolism

Primarily hepatic via CYP3A4

SubstrateEnzymesProduct
Hydrocortisone
6-beta-hydrocortisolDetails
Route of eliminationCorticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.
Half life6-8 hours
ClearanceNot Available
ToxicitySide effects include inhibition of bone formation, suppression of calcium absorption and delayed wound healing
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9918
Blood Brain Barrier+0.9383
Caco-2 permeable-0.5096
P-glycoprotein substrateSubstrate0.7861
P-glycoprotein inhibitor INon-inhibitor0.7847
P-glycoprotein inhibitor IINon-inhibitor0.8383
Renal organic cation transporterNon-inhibitor0.7463
CYP450 2C9 substrateNon-substrate0.8496
CYP450 2D6 substrateNon-substrate0.9138
CYP450 3A4 substrateSubstrate0.7407
CYP450 1A2 substrateNon-inhibitor0.9406
CYP450 2C9 inhibitorNon-inhibitor0.9072
CYP450 2D6 inhibitorNon-inhibitor0.9418
CYP450 2C19 inhibitorNon-inhibitor0.9253
CYP450 3A4 inhibitorNon-inhibitor0.8902
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9095
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.9597
BiodegradationNot ready biodegradable0.925
Rat acute toxicity1.8914 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.95
hERG inhibition (predictor II)Non-inhibitor0.584
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Hi tech pharmacal co inc
  • Allergan herbert div allergan inc
  • Del ray laboratories inc
  • Salix pharmaceuticals inc
  • Bayer pharmaceuticals corp
  • Monarch pharmaceuticals inc
  • Valeant pharmaceuticals international
  • Westwood squibb pharmaceuticals inc
  • C and m pharmacal inc
  • Pharmaceutical assoc inc div beach products
  • Actavis mid atlantic llc
  • Alpharma us pharmaceuticals division
  • Altana inc
  • Ambix laboratories div organics corp america
  • Everylife
  • E fougera div altana inc
  • G and w laboratories inc
  • Ingram pharmaceutical co
  • Ivax pharmaceuticals inc
  • Naska pharmacal co inc div rugby darby group cosmetics
  • Perrigo new york inc
  • Pharmaderm div altana inc
  • Pharmafair inc
  • Stiefel laboratories inc
  • Syosset laboratories inc
  • Taro pharmaceuticals usa inc
  • Teva pharmaceuticals usa inc
  • Topiderm inc
  • Usl pharma inc
  • Vintage pharmaceuticals inc
  • Whiteworth towne paulsen inc
  • Sanofi aventis us llc
  • Coria laboratories ltd
  • Medicis pharmaceutical corp
  • Paddock laboratories inc
  • Ani pharmaceuticals inc
  • Teva pharmaceuticals usa
  • Healthpoint ltd
  • Allergan herbert skin care div allergan inc
  • Pharmacia and upjohn co
  • Baker norton pharmaceuticals inc
  • Solvay pharmaceuticals
  • Beta dermaceuticals inc
  • Bluline laboratories inc
  • Heran pharmaceutical inc
  • Mericon industries inc
  • Perrigo co
  • Pfizer global research development
  • Carolina medical products co
  • Dermik laboratories div aventis pharmaceuticals inc
  • Torch laboratories inc
  • X gen pharmaceuticals inc
  • Jsj pharmaceuticals llc
  • Pfizer laboratories div pfizer inc
  • Barr laboratories inc
  • Elkins sinn div ah robins co inc
  • John j ferrante
  • Impax laboratories inc
  • Inwood laboratories inc sub forest laboratories inc
  • Lannett co inc
  • Nexgen pharma inc
  • Panray corp sub ormont drug and chemical co inc
  • Parke davis div warner lambert co
  • Purepac pharmaceutical co
  • Roxane laboratories inc
  • Sandoz inc
  • Stiefel a gsk co
  • Vintage pharmaceuticals llc
  • Watson laboratories inc
  • West ward pharmaceutical corp
  • Merck and co inc
  • Pfipharmecs div pfizer inc
  • Schwarz pharma inc
  • Able laboratories inc
  • Hr cenci laboratories inc
  • Ferndale laboratories inc
  • Akorn inc
  • Bel mar laboratories inc
  • Colgate oral pharmaceuticals inc
  • Taro pharmaceutical industries ltd
  • Triax pharmaceuticals llc
  • Yamanouchi europe bv
  • Savage laboratories inc div altana inc
  • Abbott laboratories pharmaceutical products div
  • Abbott laboratories hosp products div
  • Hospira inc
  • Abraxis pharmaceutical products
  • Baxter healthcare corp anesthesia and critical care
  • International medication systems ltd
  • Taro pharmaceuticals inc
  • Ranbaxy laboratories inc
Packagers
Dosage forms
FormRouteStrength
Injection, powder, lyophilized, for solutionintramuscular; intravenous100 mg/2mL
Lotiontopical20 mg/mL
Creamtopical1 %
Kit
Ointmentrectal; topical
Lotiontopical1 g/100g
Solutiontopical1 g/100g
Ointmentrectal
Ointmenttopical1.02 g/100g
Jelly; creamtopical1 %
Lotiontopical.088 mL/88mL
Creamtopical.01 g/g
Creamtopical1 g/g
Suspensionauricular (otic)
Suspensionrectal100 mg/60mL
Spraytopical1 g/100g
Creamtopical0.5 %
Spraytopical10 g/mL
Ointmentophthalmic25 mg
Ointmenttopical10 mg
Tabletoral10 mg/1
Tabletoral20 mg/1
Tabletoral5 mg/1
Tabletoral10 mg
Tabletoral20 mg
Enemarectal100 mg
Enemarectal100 mg/60mL
Enema; suspensionrectal100 mg
Creamtopical1 mg
Aerosolrectal10 %
Aerosol, foamrectal1500 mg/15g
Aerosol, foamtopical1500 mg/15g
Suppositoryrectal10 mg
Suppositoryrectal40 mg
Suspensiontopical
Geltopical10 mg/g
Liquidtopical10 mg/mL
Lotiontopical10 mg/g
Solution/ dropsophthalmic
Suspension/ dropsauricular (otic)
Geltopical1 mg/g
Lotiontopical1.18 mL/118mL
Creamtopical.284 g/28.4g
Creamtopical.284 g/287.4g
Suppositoryrectal
Creamtopical2.5 %
Lotiontopical2.5 %
Solutiontopical2.5 %
Kitoral
Ointmenttopical10 mg/mL
Ointmenttopical1 mL/100mL
Creamtopical1 g/100g
Suppositoryrectal.025 g/2g
Suppositoryrectal25 mg/2g
Lotiontopical1 g/mL
Aerosol, spraytopical1.13 g/113g
Creamtopical.5 g/100g
Creamtopical1 h/100g
Creamtopical10 mg/mL
Creamtopical10 mg/g
Creamtopical25 mg/g
Creamtopical5 mg/g
Geltopical1 g/100g
Lotiontopical25 mg/mL
Ointmenttopical10 mg/g
Ointmenttopical25 mg/g
Ointmenttopical25 mg/1
Ointmenttopical5 mg/g
Ointmenttopical1.12 g/100g
Suppositoryrectal25 mg/1
Suppositoryrectal30 mg/1
Creamtopical500 mg
Creamtopical1 g
Creamtopical5 mg
Creamtopical10 mg
Ointmenttopical0.5 %
Ointmenttopical1 %
Powder for solutionintramuscular; intravenous100 mg
Powder for solutionintramuscular; intravenous250 mg
Powder for solutionintramuscular; intravenous500 mg
Powder for solutionintramuscular; intravenous1 g
Creamtopical140 mg/14g
Creamtopical2 mg/g
Lotiontopical1 g/100mL
Creamtopical0.2 %
Ointmenttopical0.2 %
Lotiontopical1 g/88mL
Ointmenttopical1 g/100g
Creamtopical.5 %
Creamrectal; topical
Creamrectal
Gelrectal
Lotiontopical1 mg/mL
Ointmenttopical1 mg/g
Solutiontopical1 mg/mL
Liquidtopical5 mg/mL
Liquidtopical9 mg/mL
Spraytopical10 mg/mL
Creamtopical.009 g/1
Solution/ dropsauricular (otic)
Suspensionophthalmic
Ointmentophthalmic
Lotiontopical5 mg/g
Lotiontopical20 mg/g
Suspensionotic
Creamtopical1 mg/g
Kit
Ointmentophthalmic; otic
Suspensionophthalmic; otic
Geltopical
Creamtopical7.5 g/100mL
Lotiontopical
Ointmenttopical
Liquidtopical.28 mg/100mL
Aerosolrectal
Aerosol, foamtopical
Ointmentrectal; topical750 mg
Creamtopical1 mg/100mL
Solutionotic
Liquidtopical10 mg/g
Liquidtopical
Liquidtopical1 g/100mL
Injection, powder, for solutionintramuscular; intravascular100 mg/2mL
Injection, powder, for solutionintramuscular; intravenous100 mg/2mL
Injection, powder, for solutionintramuscular; intravenous1000 mg/8mL
Injection, powder, for solutionintramuscular; intravenous250 mg/2mL
Injection, powder, for solutionintramuscular; intravenous500 mg/4mL
Lotiontopical1 mL/100mL
Dropsophthalmic
Solutiontopical25 mg/mL
Lotiontopical1 %
Creamtopical2 %
Creamtopical1 g/100mL
Creamtopical280 mg/28g
Creamtopical1.12 g/100g
Solutionauricular (otic)
Ointmenttopical2 mg/g
Creamtopical
Creamtopical10 mg/L
Spraytopical10 g/L
Prices
Unit descriptionCostUnit
Locoid Lipocream 0.1% Cream 60 gm Tube335.36USD tube
Cortifoam 90 mg Foam 15 gm Can239.99USD can
Locoid 0.1% Solution 60ml Bottle233.15USD bottle
Locoid Lipocream 0.1% Cream 45 gm Tube200.98USD tube
Locoid 0.1% Cream 45 gm Tube183.83USD tube
Locoid 0.1% Ointment 45 gm Tube174.86USD tube
Pandel 0.1% Cream 45 gm Tube161.37USD tube
Pandel 0.1% Cream 15 gm Tube138.56USD tube
Proctocort 1% Cream 28.35 gm Tube127.51USD tube
Anusol-HC 2.5% Cream 30 gm Tube106.45USD tube
Locoid Lipocream 0.1% Cream 15 gm Tube85.41USD tube
Texacort 2.5% Solution 30ml Bottle85.41USD bottle
Cortisporin 3.5-10000-1 Solution 10ml Bottle84.33USD bottle
Proctofoam HC 1-1% Foam 10 gm Can81.9USD can
Cortisporin 3.5-10000-1 Suspension 10ml Bottle79.55USD bottle
Locoid 0.1% Solution 20ml Bottle79.28USD bottle
Cortisporin 1% Ointment 15 gm Tube75.09USD tube
Locoid 0.1% Cream 15 gm Tube67.49USD tube
Hydrocortisone Ace-Pramoxine 2.5-1% Cream 28.35 gm Tube64.75USD tube
Locoid 0.1% Ointment 15 gm Tube62.04USD tube
Hydrocortisone Valerate 0.2% Ointment 60 gm Tube56.74USD tube
Hydrocortisone 2.5% Lotion 59 gm Bottle55.61USD bottle
Westcort 0.2% Ointment 60 gm Tube55.0USD tube
Cortisporin 0.5-0.5-10000 Cream 7.5 gm Tube54.37USD tube
Westcort 0.2% Ointment 15 gm Tube50.99USD tube
Hydrocortisone Butyrate 0.1% Cream 45 gm Tube49.43USD tube
Hydrocortisone Valerate 0.2% Ointment 45 gm Tube48.73USD tube
Hydrocortisone 2.5% Lotion 59ml Bottle47.47USD bottle
Westcort 0.2% Ointment 45 gm Tube46.97USD tube
Hydrocortisone Valerate 0.2% Cream 60 gm Tube44.99USD tube
Hydrocortisone Valerate 0.2% Cream 45 gm Tube33.99USD tube
Ala Scalp 2% Lotion 29.6ml Bottle30.99USD bottle
Hydrocortisone Valerate 0.2% Ointment 15 gm Tube30.56USD tube
Westcort 0.2% Cream 15 gm Tube25.99USD tube
Hydrocortisone Valerate 0.2% Cream 15 gm Tube19.99USD tube
Cortisporin eye drops19.74USD ml
Solu-Cortef 1 g/vial17.55USD vial
Hydrocortisone 1% Lotion 118ml Bottle15.99USD bottle
Hydrocortisone Acetate 12 25 mg Suppository Box15.01USD box
Hydrocortisone 2.5% Ointment 28.35 gm Tube13.68USD tube
Hydrocortisone 2.5% Cream 30 gm Tube13.67USD tube
Colocort 100 mg/60ml Enema 60ml Bottle13.15USD bottle
Hydrocortisone 100 mg/60ml Enema 60ml Bottle12.6USD bottle
Hydrocortisone 0.5% Cream 28.35 gm Tube11.99USD tube
Hydrocortisone 1% Cream 15 gm Tube11.99USD tube
Hydrocortisone 1% Cream 28 gm Tube11.99USD tube
Hydrocortisone Acetate 1-1% Ointment 30 gm Tube11.99USD tube
Solu-Cortef 500 mg/vial10.47USD vial
Hydrocortisone hemisucc powder9.9USD g
Cortifoam 10% aerosol9.35USD g
Hydrocortisone Sod. Succinate 1 g/vial9.01USD vial
Solu-cortef (pf) 250 mg vial8.58USD vial
Cortisporin-tc ear susp8.3USD ml
Cortisporin ear suspension7.86USD ml
Solu-Cortef 250 mg/vial7.05USD vial
Cortenema (100 mg/60Ml) 100 mg/enm Enema6.96USD enema
Proctofoam-hc foam6.77USD g
Cortifoam 10 % Foam6.14USD g
Hycort (100 mg/60Ml) 100 mg/enm Enema5.79USD enema
Cortamed 2.5 % Ointment5.67USD g
Hydrocortisone Sod. Succinate 500 mg/vial5.34USD vial
Hydrocortisone powder5.19USD g
Solu-cortef (pf) 100 mg vial4.85USD vial
Solu-cortef 100 mg vial4.63USD vial
Proctocort 1% cream4.37USD g
Pandel 0.1% cream4.34USD g
Locoid 0.1% lipocream4.3USD g
Solu-Cortef 100 mg/vial4.07USD vial
Locoid 0.1% cream3.92USD g
Hydrocortisone Sod. Succinate 250 mg/vial3.56USD vial
Hydrocortisone ss 250 mg vial3.5USD vial
Anusol-hc 2.5% cream3.45USD g
Hydrocortisone acet powder3.15USD g
Proctofoam2.89USD g
A-hydrocort 100 mg vial2.42USD each
Proctocream-hc 2.5% cream2.17USD g
Hydrocortisone Sod. Succinate 100 mg/vial2.1USD vial
Hydrocortisone val 0.2% cream2.07USD g
Hytone 2.5% cream1.46USD g
Hydrocortisone buty 0.1% cream1.31USD g
First hydrocort 10% gel1.18USD g
Westcort 0.2% cream1.17USD g
Procto-kit 1% cream1.08USD g
Ala-scalp hp 2% lotion1.03USD ml
Cortef 20 mg tablet0.9USD tablet
Proctosol-hc 2.5% cream0.89USD g
Proctozone-hc 2.5% cream0.83USD g
Orabase plain paste0.77USD g
Hydrocortisone 2.5% lotion0.6USD ml
Cortef 10 mg tablet0.55USD tablet
Orabase-b 20% gel0.55USD g
Hydrocortisone 2.5% cream0.53USD g
Hydrocortisone 10 mg tablet0.52USD tablet
Cortef 5 mg tablet0.45USD tablet
Ala-cort 1% cream0.43USD g
Hydrocortisone 5 mg tablet0.38USD tablet
Corticaine 0.5% cream0.37USD g
Hydrocortisone 20 mg tablet0.32USD tablet
Prevex Hc 1 % Occlusive Cream0.3USD g
Emo-Cort 2.5 % Cream0.26USD g
Preparation h 1% cream0.24USD g
Tucks hydrocortisone ointment0.24USD g
Emo-Cort 2.5 % Lotion0.23USD g
Emo-Cort Scalp 2.5 % Lotion0.22USD g
Colocort 100 mg enema0.21USD ml
Cortenema 100 mg enema0.21USD ml
Sarna Hc 2.5 % Lotion0.2USD g
Emo-Cort 1 % Cream0.19USD g
Balneol lotion0.18USD ml
Emo-Cort 1 % Lotion0.18USD g
Lanacort 1% cool creme0.18USD g
Hyderm 0.5 % Cream0.18USD g
Hytone 1% cream0.17USD g
Cortoderm Mild 0.5 % Ointment0.15USD g
Beta hc 1% lotion0.14USD ml
Cortizone-10 1% spray0.14USD ml
Hydroval 0.2 % Cream0.13USD g
Hydroval 0.2 % Ointment0.13USD g
Aquanil hc 1% lotion0.12USD ml
Hydrocortisone plus 12 1% crm0.12USD g
Scalpicin 3% liquid0.12USD ml
Slender cortisol capsule0.12USD capsule
Cortaid 1% spray0.1USD ml
Sarna Hc 1 % Lotion0.1USD g
Hydrocortisone 0.5% cream0.08USD g
Hydrocortisone 1% cream0.08USD g
Uniderm moisturizer0.05USD ml
Cortoderm Regular 1 % Ointment0.04USD g
Hyderm 1 % Cream0.04USD g
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5635497 No1994-06-032014-06-03Us
US6514980 No1999-01-242019-01-24Us
US7223387 No2001-07-242021-07-24Us
US7378405 No2006-12-192026-12-19Us
US7981877 No2005-01-232025-01-23Us
USRE39264 No1996-08-022016-08-02Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point220 °CPhysProp
water solubility320 mg/L (at 25 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP1.61HANSCH,C ET AL. (1995)
logS-2.97ADME Research, USCD
Caco2 permeability-4.66ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility0.199 mg/mLALOGPS
logP1.79ALOGPS
logP1.28ChemAxon
logS-3.3ALOGPS
pKa (Strongest Acidic)12.58ChemAxon
pKa (Strongest Basic)-2.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area94.83 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity97.4 m3·mol-1ChemAxon
Polarizability39.55 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (2.96 KB)
Spectra
Spectrum TypeDescriptionSplash Key
GC-MSGC-MS Spectrum - GC-MS (2 MEOX; 3 TMS)splash10-0f7o-3930000000-b7b43b2fc9f20acfd20bView in MoNA
References
Synthesis Reference

Manfred Baumgarth, Dieter Orth, Jurgen Harting, Hans Schaefer, Achim Zesch, “Hydrocortisone orthoesters, pharmaceutical formulations thereof and processes for the preparation thereof.” U.S. Patent US4264584, issued March, 1974.

US4264584
General References
  1. de Weerth C, Zijl RH, Buitelaar JK: Development of cortisol circadian rhythm in infancy. Early Hum Dev. 2003 Aug;73(1-2):39-52. [PubMed:12932892 ]
  2. Palacios R, Sugawara I: Hydrocortisone abrogates proliferation of T cells in autologous mixed lymphocyte reaction by rendering the interleukin-2 Producer T cells unresponsive to interleukin-1 and unable to synthesize the T-cell growth factor. Scand J Immunol. 1982 Jan;15(1):25-31. [PubMed:6461917 ]
  3. KNIGHT RP Jr, KORNFELD DS, GLASER GH, BONDY PK: Effects of intravenous hydrocortisone on electrolytes of serum and urine in man. J Clin Endocrinol Metab. 1955 Feb;15(2):176-81. [PubMed:13233328 ]
External Links
ATC CodesA01AC03A07EA02C05AA01D07AA02D07AB02D07AC16D07BA04D07BB04D07CA01D07XA01H02AB09R01AD60S01BA02S01BB01S01CA03S01CB03S02BA01S02CA03S03CA04
AHFS Codes
  • 52:08.08
  • 68:04.00
  • 84:06.00
PDB EntriesNot Available
FDA labelDownload (30 KB)
MSDSDownload (73.6 KB)
Interactions
Drug Interactions
Drug
AcetohexamideThe therapeutic efficacy of Acetohexamide can be decreased when used in combination with Hydrocortisone.
Acetylsalicylic acidThe risk or severity of adverse effects can be increased when Acetylsalicylic acid is combined with Hydrocortisone.
AldesleukinHydrocortisone may decrease the antineoplastic activities of Aldesleukin.
AlogliptinThe therapeutic efficacy of Alogliptin can be decreased when used in combination with Hydrocortisone.
Aluminum hydroxideThe bioavailability of Hydrocortisone can be decreased when combined with Aluminum hydroxide.
Amphotericin BHydrocortisone may increase the hypokalemic activities of Amphotericin B.
AprepitantThe serum concentration of Hydrocortisone can be increased when it is combined with Aprepitant.
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Hydrocortisone.
Atracurium besylateAtracurium besylate may increase the adverse neuromuscular activities of Hydrocortisone.
Benzoic AcidThe therapeutic efficacy of Benzoic Acid can be decreased when used in combination with Hydrocortisone.
CalcitriolThe therapeutic efficacy of Calcitriol can be decreased when used in combination with Hydrocortisone.
Calcium carbonateThe bioavailability of Hydrocortisone can be decreased when combined with Calcium carbonate.
CanagliflozinThe therapeutic efficacy of Canagliflozin can be decreased when used in combination with Hydrocortisone.
CapromabHydrocortisone may decrease effectiveness of Capromab as a diagnostic agent.
CarbamazepineThe serum concentration of Hydrocortisone can be decreased when it is combined with Carbamazepine.
CeritinibHydrocortisone may increase the hyperglycemic activities of Ceritinib.
ChlorotrianiseneThe serum concentration of Hydrocortisone can be increased when it is combined with Chlorotrianisene.
ChlorpropamideThe therapeutic efficacy of Chlorpropamide can be decreased when used in combination with Hydrocortisone.
ColesevelamColesevelam can cause a decrease in the absorption of Hydrocortisone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Corticorelin ovine triflutateThe therapeutic efficacy of Corticorelin can be decreased when used in combination with Hydrocortisone.
DeferasiroxThe risk or severity of adverse effects can be increased when Hydrocortisone is combined with Deferasirox.
DenosumabThe risk or severity of adverse effects can be increased when Denosumab is combined with Hydrocortisone.
DesmopressinThe risk or severity of adverse effects can be increased when Hydrocortisone is combined with Desmopressin.
DihydrotestosteroneHydrocortisone may increase the fluid retaining activities of Dihydrotestosterone.
EnzalutamideThe serum concentration of Hydrocortisone can be decreased when it is combined with Enzalutamide.
FosaprepitantThe serum concentration of Hydrocortisone can be increased when it is combined with Fosaprepitant.
FosphenytoinThe serum concentration of Hydrocortisone can be decreased when it is combined with Fosphenytoin.
GliclazideThe therapeutic efficacy of Gliclazide can be decreased when used in combination with Hydrocortisone.
GlimepirideThe therapeutic efficacy of Glimepiride can be decreased when used in combination with Hydrocortisone.
GliquidoneThe therapeutic efficacy of Gliquidone can be decreased when used in combination with Hydrocortisone.
GlyburideThe therapeutic efficacy of Glyburide can be decreased when used in combination with Hydrocortisone.
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Hydrocortisone.
HydrocodoneThe serum concentration of Hydrocodone can be decreased when it is combined with Hydrocortisone.
IcosapentThe risk or severity of adverse effects can be increased when Hydrocortisone is combined with Icosapent.
IndacaterolIndacaterol may increase the hypokalemic activities of Hydrocortisone.
Insulin AspartThe therapeutic efficacy of Insulin Aspart can be decreased when used in combination with Hydrocortisone.
Insulin DetemirThe therapeutic efficacy of Insulin Detemir can be decreased when used in combination with Hydrocortisone.
Insulin GlargineThe therapeutic efficacy of Insulin Glargine can be decreased when used in combination with Hydrocortisone.
Insulin GlulisineThe therapeutic efficacy of Insulin Glulisine can be decreased when used in combination with Hydrocortisone.
Insulin HumanThe therapeutic efficacy of Insulin Regular can be decreased when used in combination with Hydrocortisone.
Insulin LisproThe therapeutic efficacy of Insulin Lispro can be decreased when used in combination with Hydrocortisone.
IsoniazidThe serum concentration of Isoniazid can be decreased when it is combined with Hydrocortisone.
LeflunomideThe risk or severity of adverse effects can be increased when Hydrocortisone is combined with Leflunomide.
LinagliptinThe therapeutic efficacy of Linagliptin can be decreased when used in combination with Hydrocortisone.
LumacaftorThe serum concentration of Hydrocortisone can be decreased when it is combined with Lumacaftor.
Magnesium oxideThe bioavailability of Hydrocortisone can be decreased when combined with Magnesium oxide.
MetforminThe therapeutic efficacy of Metformin can be decreased when used in combination with Hydrocortisone.
MifepristoneThe therapeutic efficacy of Hydrocortisone can be decreased when used in combination with Mifepristone.
MitotaneThe serum concentration of Hydrocortisone can be decreased when it is combined with Mitotane.
NatalizumabThe risk or severity of adverse effects can be increased when Hydrocortisone is combined with Natalizumab.
NelfinavirThe serum concentration of Hydrocortisone can be increased when it is combined with Nelfinavir.
NicorandilThe risk or severity of adverse effects can be increased when Hydrocortisone is combined with Nicorandil.
NimodipineThe serum concentration of Nimodipine can be decreased when it is combined with Hydrocortisone.
OxandroloneHydrocortisone may increase the fluid retaining activities of Oxandrolone.
PhenobarbitalThe serum concentration of Hydrocortisone can be decreased when it is combined with Phenobarbital.
PhenytoinThe serum concentration of Hydrocortisone can be decreased when it is combined with Phenytoin.
PimecrolimusThe risk or severity of adverse effects can be increased when Pimecrolimus is combined with Hydrocortisone.
PrimidoneThe serum concentration of Hydrocortisone can be decreased when it is combined with Primidone.
RanolazineThe serum concentration of Hydrocortisone can be increased when it is combined with Ranolazine.
RepaglinideThe therapeutic efficacy of Repaglinide can be decreased when used in combination with Hydrocortisone.
RifabutinThe serum concentration of Hydrocortisone can be decreased when it is combined with Rifabutin.
RifampicinThe serum concentration of Hydrocortisone can be decreased when it is combined with Rifampicin.
RifapentineThe serum concentration of Hydrocortisone can be decreased when it is combined with Rifapentine.
RoflumilastRoflumilast may increase the immunosuppressive activities of Hydrocortisone.
SaquinavirThe serum concentration of Hydrocortisone can be increased when it is combined with Saquinavir.
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Hydrocortisone.
Sipuleucel-TThe therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Hydrocortisone.
SparfloxacinThe risk or severity of adverse effects can be increased when Hydrocortisone is combined with Sparfloxacin.
TacrineThe risk or severity of adverse effects can be increased when Hydrocortisone is combined with Tacrine.
TacrolimusThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Hydrocortisone.
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Hydrocortisone.
TesmilifeneThe serum concentration of Hydrocortisone can be decreased when it is combined with Tesmilifene.
TestosteroneHydrocortisone may increase the fluid retaining activities of Testosterone.
TofacitinibHydrocortisone may increase the immunosuppressive activities of Tofacitinib.
TolbutamideThe therapeutic efficacy of Tolbutamide can be decreased when used in combination with Hydrocortisone.
TorasemideHydrocortisone may increase the hypokalemic activities of Torasemide.
TrastuzumabTrastuzumab may increase the neutropenic activities of Hydrocortisone.
TrichlormethiazideHydrocortisone may increase the hypokalemic activities of Trichlormethiazide.
VerapamilThe serum concentration of Hydrocortisone can be increased when it is combined with Verapamil.
VildagliptinThe therapeutic efficacy of Vildagliptin can be decreased when used in combination with Hydrocortisone.
WarfarinHydrocortisone may increase the anticoagulant activities of Warfarin.
Food Interactions
  • Take with food to reduce irritation. Calcium, phosphorous, potassium, Vitamin A, C, D and zinc needs increased with long term use.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Zinc ion binding
Specific Function:
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon grow...
Gene Name:
NR3C1
Uniprot ID:
P04150
Molecular Weight:
85658.57 Da
References
  1. Grossman R, Yehuda R, Golier J, McEwen B, Harvey P, Maria NS: Cognitive effects of intravenous hydrocortisone in subjects with PTSD and healthy control subjects. Ann N Y Acad Sci. 2006 Jul;1071:410-21. [PubMed:16891588 ]
  2. Rautanen A, Eriksson JG, Kere J, Andersson S, Osmond C, Tienari P, Sairanen H, Barker DJ, Phillips DI, Forsen T, Kajantie E: Associations of body size at birth with late-life cortisol concentrations and glucose tolerance are modified by haplotypes of the glucocorticoid receptor gene. J Clin Endocrinol Metab. 2006 Nov;91(11):4544-51. Epub 2006 Aug 8. [PubMed:16895953 ]
  3. Hammer F, Stewart PM: Cortisol metabolism in hypertension. Best Pract Res Clin Endocrinol Metab. 2006 Sep;20(3):337-53. [PubMed:16980198 ]
  4. Shaw JR, Gabor K, Hand E, Lankowski A, Durant L, Thibodeau R, Stanton CR, Barnaby R, Coutermarsh B, Karlson KH, Sato JD, Hamilton JW, Stanton BA: Role of glucocorticoid receptor in acclimation of killifish (Fundulus heteroclitus) to seawater and effects of arsenic. Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R1052-60. Epub 2006 Oct 12. [PubMed:17038445 ]
  5. Sher L: Combined dexamethasone suppression-corticotropin-releasing hormone stimulation test in studies of depression, alcoholism, and suicidal behavior. ScientificWorldJournal. 2006 Oct 31;6:1398-404. [PubMed:17086345 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Structural molecule activity
Specific Function:
Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Promotes resolution of inflammation and wound healing (PubMed:25664854). Functions ...
Gene Name:
ANXA1
Uniprot ID:
P04083
Molecular Weight:
38713.855 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Sato-Matsumura KC, Matsumura T, Nakamura H, Sawa H, Nagashima K, Koizumi H: Membrane expression of annexin I is enhanced by calcium and TPA in cultured human keratinocytes. Arch Dermatol Res. 2000 Oct;292(10):496-9. [PubMed:11142771 ]
  4. White MV, Igarashi Y, Lundgren JD, Shelhamer J, Kaliner M: Hydrocortisone inhibits rat basophilic leukemia cell mediator release induced by neutrophil-derived histamine releasing activity as well as by anti-IgE. J Immunol. 1991 Jul 15;147(2):667-73. [PubMed:1712816 ]
  5. Serres M, Viac J, Comera C, Schmitt D: Expression of annexin I in freshly isolated human epidermal cells and in cultured keratinocytes. Arch Dermatol Res. 1994;286(5):268-72. [PubMed:8060156 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Ekins S, Bravi G, Wikel JH, Wrighton SA: Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates. J Pharmacol Exp Ther. 1999 Oct;291(1):424-33. [PubMed:10490933 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid 11-beta-monooxygenase activity
Specific Function:
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.
Gene Name:
CYP11B1
Uniprot ID:
P15538
Molecular Weight:
57572.44 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid 11-beta-monooxygenase activity
Specific Function:
Preferentially catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and 18-hydroxycorticosterone.
Gene Name:
CYP11B2
Uniprot ID:
P19099
Molecular Weight:
57559.62 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Androgen binding
Specific Function:
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.
Gene Name:
SHBG
Uniprot ID:
P04278
Molecular Weight:
43778.755 Da
References
  1. Khoromi S, Muniyappa R, Nackers L, Gray N, Baldwin H, Wong KA, Matheny LA, Moquin B, Rainer A, Hill S, Remaley A, Johnson LL, Max MB, Blackman MR: Effects of chronic osteoarthritis pain on neuroendocrine function in men. J Clin Endocrinol Metab. 2006 Nov;91(11):4313-8. Epub 2006 Aug 15. [PubMed:16912126 ]
  2. Stroud LR, Solomon C, Shenassa E, Papandonatos G, Niaura R, Lipsitt LP, Lewinn K, Buka SL: Long-term stability of maternal prenatal steroid hormones from the National Collaborative Perinatal Project: still valid after all these years. Psychoneuroendocrinology. 2007 Feb;32(2):140-50. Epub 2007 Jan 31. [PubMed:17270355 ]
  3. Lombardi G, Mondaini N, Macchiarella A, Del Popolo G: Female sexual dysfunction and hormonal status in spinal cord injured (SCI) patients. J Androl. 2007 Sep-Oct;28(5):722-6. Epub 2007 May 9. [PubMed:17494102 ]
  4. Shifren JL, Desindes S, McIlwain M, Doros G, Mazer NA: A randomized, open-label, crossover study comparing the effects of oral versus transdermal estrogen therapy on serum androgens, thyroid hormones, and adrenal hormones in naturally menopausal women. Menopause. 2007 Nov-Dec;14(6):985-94. [PubMed:17507833 ]
  5. Rizzo L, Dobrovsky V, Danilowicz K, Kral M, Cross G, Serra HA, Bruno OD: Low-dose glucocorticoids in hyperandrogenism. Medicina (B Aires). 2007;67(3):247-52. [PubMed:17628912 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Steroid binding
Specific Function:
Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
Gene Name:
SERPINA6
Uniprot ID:
P08185
Molecular Weight:
45140.49 Da
References
  1. Henley DE, Lightman SL: New insights into corticosteroid-binding globulin and glucocorticoid delivery. Neuroscience. 2011 Apr 28;180:1-8. doi: 10.1016/j.neuroscience.2011.02.053. Epub 2011 Mar 1. [PubMed:21371536 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. [PubMed:12699389 ]
  2. Kim RB, Wandel C, Leake B, Cvetkovic M, Fromm MF, Dempsey PJ, Roden MM, Belas F, Chaudhary AK, Roden DM, Wood AJ, Wilkinson GR: Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Pharm Res. 1999 Mar;16(3):408-14. [PubMed:10213372 ]
  3. Yates CR, Chang C, Kearbey JD, Yasuda K, Schuetz EG, Miller DD, Dalton JT, Swaan PW: Structural determinants of P-glycoprotein-mediated transport of glucocorticoids. Pharm Res. 2003 Nov;20(11):1794-803. [PubMed:14661924 ]
  4. Ueda K, Okamura N, Hirai M, Tanigawara Y, Saeki T, Kioka N, Komano T, Hori R: Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone. J Biol Chem. 1992 Dec 5;267(34):24248-52. [PubMed:1360010 ]
  5. Orlowski S, Mir LM, Belehradek J Jr, Garrigos M: Effects of steroids and verapamil on P-glycoprotein ATPase activity: progesterone, desoxycorticosterone, corticosterone and verapamil are mutually non-exclusive modulators. Biochem J. 1996 Jul 15;317 ( Pt 2):515-22. [PubMed:8713080 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. Kanai N, Lu R, Bao Y, Wolkoff AW, Schuster VL: Transient expression of oatp organic anion transporter in mammalian cells: identification of candidate substrates. Am J Physiol. 1996 Feb;270(2 Pt 2):F319-25. [PubMed:8779893 ]
  2. Bossuyt X, Muller M, Hagenbuch B, Meier PJ: Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver. J Pharmacol Exp Ther. 1996 Mar;276(3):891-6. [PubMed:8786566 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from t...
Gene Name:
ABCG2
Uniprot ID:
Q9UNQ0
Molecular Weight:
72313.47 Da
References
  1. Imai Y, Asada S, Tsukahara S, Ishikawa E, Tsuruo T, Sugimoto Y: Breast cancer resistance protein exports sulfated estrogens but not free estrogens. Mol Pharmacol. 2003 Sep;64(3):610-8. [PubMed:12920197 ]
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Drug created on June 13, 2005 07:24 / Updated on May 24, 2016 02:07