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Identification
NameTelaprevir
Accession NumberDB05521
TypeSmall Molecule
GroupsApproved
DescriptionTelaprevir (VX-950) is a highly selective and potent inhibitor of the HCV NS3-4A serine protease. It is a member of a class of antiviral drugs known as protease inhibitors and is the first hepatitis C drug that has demonstrated activity in patients who have failed prior therapy. On April 28, 2011, the FDA Antiviral Drugs Advisory Committee voted 18-0 to recommend approval telaprevir for people with genotype 1 chronic hepatitis C and was approved in the U.S. in May, 2011.
Structure
Thumb
Synonyms
(1S,3AR,6as)-(2S)-2-cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-((1S)-1-((cyclopropylamino)oxoacetyl)butyl)octahydrocyclopenta(c)pyrrole-1-carboxamide
Incivek
MP-424
VX 950
VX-950
External Identifiers
  • AIDS-213006
  • AIDS213006
  • LY-570310
  • VRT111950
  • VX-950
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Incivektablet375 mgoralVertex Pharmaceuticals (Canada) Incorporated2011-10-032015-04-21Canada
IncivoFilm-coated tablet375 mgOral useJanssen Cilag International N.V.2011-09-19Not applicableEu
IncivoFilm-coated tablet375 mgOral useJanssen Cilag International N.V.2011-09-19Not applicableEu
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNII655M5O3W0U
CAS number402957-28-2
WeightAverage: 679.8493
Monoisotopic: 679.405732463
Chemical FormulaC36H53N7O6
InChI KeyInChIKey=BBAWEDCPNXPBQM-GDEBMMAJSA-N
InChI
InChI=1S/C36H53N7O6/c1-5-10-25(29(44)34(48)39-23-15-16-23)40-33(47)28-24-14-9-13-22(24)20-43(28)35(49)30(36(2,3)4)42-32(46)27(21-11-7-6-8-12-21)41-31(45)26-19-37-17-18-38-26/h17-19,21-25,27-28,30H,5-16,20H2,1-4H3,(H,39,48)(H,40,47)(H,41,45)(H,42,46)/t22-,24-,25-,27-,28-,30+/m0/s1
IUPAC Name
(3S)-3-{[(1S,3aR,6aS)-2-[(2S)-2-[(2S)-2-cyclohexyl-2-(pyrazin-2-ylformamido)acetamido]-3,3-dimethylbutanoyl]-octahydrocyclopenta[c]pyrrol-1-yl]formamido}-N-cyclopropyl-2-oxohexanamide
SMILES
[H][C@@]12CCC[C@]1([H])[[email protected]](N(C2)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)C1=NC=CN=C1)C1CCCCC1)C(C)(C)C)C(=O)N[C@@H](CCC)C(=O)C(=O)NC1CC1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as hybrid peptides. These are compounds containing at least two different types of amino acids (alpha, beta, gamma, delta) linked to each other through a peptide bond.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentHybrid peptides
Alternative Parents
Substituents
  • Hybrid peptide
  • N-acyl-alpha amino acid or derivatives
  • Alpha-amino acid amide
  • N-substituted-alpha-amino acid
  • Pyrazinecarboxamide
  • Pyrazine carboxylic acid or derivatives
  • Pyrrolidine-2-carboxamide
  • Pyrrolidine carboxylic acid or derivatives
  • N-acylpyrrolidine
  • Fatty acyl
  • Pyrazine
  • N-acyl-amine
  • Fatty amide
  • Heteroaromatic compound
  • Tertiary carboxylic acid amide
  • Pyrrolidine
  • Cyclic alcohol
  • Alpha-aminoketone
  • Tertiary amine
  • Secondary carboxylic acid amide
  • Ketone
  • Carboxamide group
  • Azacycle
  • Organoheterocyclic compound
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationTreating chronic hepatitis C virus (genotype 1) infection in patients with compensated liver (due to liver diseases like cirrhosis) that are treatment naive or have failed therapy with interferons (either null or partial responders and treatment relapsers).
PharmacodynamicsTelaprevir is a direct-acting antiviral agent (DAA) against the hepatitis C virus. In a biochemical assay, telaprevir inhibited the proteolytic activity of the recombinant HCV NS3 protease domain with an IC50 value of 10 nM.
Mechanism of actionTelaprevir is an inhibitor of the HCV NS3/4A serine protease, necessary for the proteolytic cleavage of the HCV encoded polyprotein into mature forms of the NS4A, NS4B, NS5A and NS5B proteins and essential for viral replication. It belongs to the chemical class of alpha-ketoamids and binds to NS3/4A in a covalent but reversible manner.
Related Articles
AbsorptionTelaprevir is orally available, most likely absorbed in the small intestine, with no evidence for absorption in the colon. Maximum plasma concentrations after a single dose of telaprevir are generally achieved after 4 to 5 hours. In vitro studies performed with human Caco-2 cells indicated that telaprevir is a substrate of P-glycoprotein (P-gp). Exposure to telaprevir is higher during co-administration of peginterferon alfa and ribavirin than after administration of telaprevir alone. Dissolution of telaprevir is not dependent by pH.
Volume of distribution

Apparent volume of distribution (Vd/F) = 252 L. This large volume of distribution suggests extensive penetration into tissues.

Protein binding59% to 76% and binds to alpha 1-acid glycoprotein and albumin in a concentration dependent manner.
Metabolism

Telaprevir is extensively metabolized in the liver, involving hydrolysis, oxidation, and reduction. Multiple metabolites were detected in feces, plasma, and urine. After repeated-oral administration, the R-diastereomer of telaprevir (30-fold less active), pyrazinoic acid, and a metabolite that underwent reduction at the α-ketoamide bond of telaprevir (not active) were found to be the predominant metabolites of telaprevir. In vitro studies using recombinant human cytochrome P450 (CYP) isoforms indicated that CYP3A4 was the major CYP isoform responsible for telaprevir metabolism. However, non-CYP mediated metabolism likely plays a role after multiple dosing of telaprevir.

SubstrateEnzymesProduct
Telaprevir
Not Available
Pyrazinoic acidDetails
Route of eliminationFollowing administration of a single oral dose of 750 mg 14C-telaprevir in healthy subjects, 90% of total radioactivity was recovered in feces, urine and expired air within 96 hours post-dose. The median recovery of the administered radioactive dose was approximately 82% in the feces, 9% in exhaled air and 1% in urine. The contribution of unchanged 14C-telaprevir and the R-diastereomer of telaprevir towards total radioactivity recovered in feces was 31.9% and 18.8%, respectively.
Half lifeThe mean elimination half-life after single-dose oral administration of telaprevir 750 mg typically ranged from about 4.0 to 4.7 hours. At steady state, the effective half-life is about 9 to 11 hours.
Clearance

After oral administration, the apparent total clearance (Cl/F) was estimated to be 32.4 L/h with an inter-individual variability of 27.2%.

ToxicityThe highest documented dose administered is 1875 mg every 8 hours for 4 days in healthy subjects with telaprevir alone. In that study, the following common adverse events were reported more frequently with the 1875 mg q8h regimen compared to the 750 mg q8h regimen: nausea, headache, diarrhea, decreased appetite, dysgeusia, and vomiting. The two most common adverse events that caused the discontinuation of treatment are anemia and rash.
Affected organisms
  • Hepatitis C virus, RSV and other RNA/DNA viruses
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9547
Blood Brain Barrier-0.9659
Caco-2 permeable-0.7982
P-glycoprotein substrateSubstrate0.8567
P-glycoprotein inhibitor IInhibitor0.9355
P-glycoprotein inhibitor IIInhibitor0.8879
Renal organic cation transporterNon-inhibitor0.8919
CYP450 2C9 substrateNon-substrate0.8245
CYP450 2D6 substrateNon-substrate0.6612
CYP450 3A4 substrateSubstrate0.7632
CYP450 1A2 substrateNon-inhibitor0.6961
CYP450 2C9 inhibitorInhibitor0.5969
CYP450 2D6 inhibitorNon-inhibitor0.7431
CYP450 2C19 inhibitorInhibitor0.5866
CYP450 3A4 inhibitorInhibitor0.8926
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.8476
Ames testNon AMES toxic0.7536
CarcinogenicityNon-carcinogens0.8622
BiodegradationNot ready biodegradable0.9954
Rat acute toxicity2.6980 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9894
hERG inhibition (predictor II)Inhibitor0.6931
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
Tabletoral375 mg
Film-coated tabletOral use375 mg
PricesNot Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US7820671 No2005-02-252025-02-25Us
US8431615 No2008-05-302028-05-30Us
US8529882 No2001-08-312021-08-31Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
water solubility0.0047 mg/mLFDA Label
Predicted Properties
PropertyValueSource
Water Solubility0.0355 mg/mLALOGPS
logP2.56ALOGPS
logP2.58ChemAxon
logS-4.3ALOGPS
pKa (Strongest Acidic)11.86ChemAxon
pKa (Strongest Basic)-0.69ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count8ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area179.56 Å2ChemAxon
Rotatable Bond Count14ChemAxon
Refractivity180.04 m3·mol-1ChemAxon
Polarizability74.37 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

Znabet A, Polak MM, Janssen E, de Kanter FJ, Turner NJ, Orru RV, Ruijter E. A highly efficient synthesis of telaprevir by strategic use of biocatalysis and multicomponent reactions. Chem Commun (Camb). 2010 Nov 14;46(42):7918-20. Epub 2010 Sep 20.

General References
  1. Kim JJ, Culley CM, Mohammad RA: Telaprevir: an oral protease inhibitor for hepatitis C virus infection. Am J Health Syst Pharm. 2012 Jan 1;69(1):19-33. doi: 10.2146/ajhp110123. [PubMed:22180548 ]
  2. Liu-Young G, Kozal MJ: Hepatitis C protease and polymerase inhibitors in development. AIDS Patient Care STDS. 2008 Jun;22(6):449-57. doi: 10.1089/apc.2007.0199. [PubMed:18479202 ]
  3. Forestier N, Zeuzem S: Telaprevir for the treatment of hepatitis C. Expert Opin Pharmacother. 2012 Mar;13(4):593-606. doi: 10.1517/14656566.2012.660524. Epub 2012 Feb 15. [PubMed:22332992 ]
  4. Garg V, Kauffman RS, Beaumont M, van Heeswijk RP: Telaprevir: pharmacokinetics and drug interactions. Antivir Ther. 2012;17(7):1211-21. doi: 10.3851/IMP2356. Epub 2012 Sep 7. [PubMed:22954756 ]
External Links
ATC CodesJ05AE11
AHFS Codes
  • 8:18.40
PDB EntriesNot Available
FDA labelDownload (508 KB)
MSDSDownload (88.2 KB)
Interactions
Drug Interactions
Drug
4-AndrostenedioneThe serum concentration of Telaprevir can be decreased when it is combined with 4-Androstenedione.
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be increased when it is combined with Telaprevir.
AbacavirThe serum concentration of Abacavir can be decreased when it is combined with Telaprevir.
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Telaprevir.
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Telaprevir.
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Telaprevir.
AcetaminophenThe serum concentration of Telaprevir can be increased when it is combined with Acetaminophen.
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Telaprevir.
AfatinibThe serum concentration of Telaprevir can be increased when it is combined with Afatinib.
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Telaprevir.
AlbendazoleThe serum concentration of Telaprevir can be increased when it is combined with Albendazole.
AlclometasoneThe serum concentration of Telaprevir can be decreased when it is combined with Alclometasone.
AlclometasoneThe serum concentration of Alclometasone can be increased when it is combined with Telaprevir.
AldosteroneThe serum concentration of Telaprevir can be decreased when it is combined with Aldosterone.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Telaprevir.
AlectinibThe serum concentration of Telaprevir can be increased when it is combined with Alectinib.
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Telaprevir.
AlfentanilThe serum concentration of Telaprevir can be increased when it is combined with Alfentanil.
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Telaprevir.
AliskirenThe metabolism of Aliskiren can be decreased when combined with Telaprevir.
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Telaprevir.
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Telaprevir.
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Telaprevir.
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Telaprevir.
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Telaprevir.
AmantadineThe serum concentration of Telaprevir can be increased when it is combined with Amantadine.
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Telaprevir.
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Telaprevir.
AmcinonideThe serum concentration of Telaprevir can be decreased when it is combined with Amcinonide.
AmcinonideThe serum concentration of Amcinonide can be increased when it is combined with Telaprevir.
AmineptineThe serum concentration of Amineptine can be increased when it is combined with Telaprevir.
Aminohippuric acidThe serum concentration of Telaprevir can be increased when it is combined with Aminohippuric acid.
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Telaprevir.
AminophyllineThe serum concentration of Aminophylline can be decreased when it is combined with Telaprevir.
AmiodaroneThe risk or severity of adverse effects can be increased when Telaprevir is combined with Amiodarone.
AmiodaroneThe serum concentration of Telaprevir can be decreased when it is combined with Amiodarone.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Telaprevir.
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Telaprevir.
AmlodipineThe serum concentration of Telaprevir can be increased when it is combined with Amlodipine.
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Telaprevir.
AmprenavirThe serum concentration of Telaprevir can be decreased when it is combined with Amprenavir.
AmsacrineThe serum concentration of Telaprevir can be increased when it is combined with Amsacrine.
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Telaprevir.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Telaprevir.
ApremilastThe metabolism of Apremilast can be decreased when combined with Telaprevir.
AprepitantThe serum concentration of Telaprevir can be increased when it is combined with Aprepitant.
AprepitantThe metabolism of Aprepitant can be decreased when combined with Telaprevir.
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Telaprevir.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Telaprevir.
ArtemetherThe metabolism of Artemether can be decreased when combined with Telaprevir.
AsenapineThe metabolism of Asenapine can be decreased when combined with Telaprevir.
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Telaprevir.
AtazanavirThe serum concentration of Telaprevir can be decreased when it is combined with Atazanavir.
AtazanavirThe metabolism of Atazanavir can be decreased when combined with Telaprevir.
AtenololThe serum concentration of Telaprevir can be increased when it is combined with Atenolol.
AtomoxetineThe metabolism of Telaprevir can be decreased when combined with Atomoxetine.
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Telaprevir.
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Telaprevir.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Telaprevir.
AzelastineThe metabolism of Azelastine can be decreased when combined with Telaprevir.
AzelastineThe serum concentration of Telaprevir can be increased when it is combined with Azelastine.
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Telaprevir.
AzithromycinThe serum concentration of Telaprevir can be increased when it is combined with Azithromycin.
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Telaprevir.
BarnidipineThe serum concentration of Barnidipine can be increased when it is combined with Telaprevir.
Beclomethasone dipropionateThe serum concentration of Telaprevir can be decreased when it is combined with Beclomethasone dipropionate.
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be increased when it is combined with Telaprevir.
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Telaprevir.
BenzocaineThe serum concentration of Telaprevir can be increased when it is combined with Benzocaine.
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Telaprevir.
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Telaprevir.
BepridilThe risk or severity of adverse effects can be increased when Telaprevir is combined with Bepridil.
BepridilThe serum concentration of Telaprevir can be increased when it is combined with Bepridil.
BetamethasoneThe serum concentration of Telaprevir can be decreased when it is combined with Betamethasone.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Telaprevir.
BexaroteneThe serum concentration of Telaprevir can be decreased when it is combined with Bexarotene.
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Telaprevir.
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Telaprevir.
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Telaprevir.
BiperidenThe serum concentration of Telaprevir can be increased when it is combined with Biperiden.
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Telaprevir.
BoceprevirThe serum concentration of Telaprevir can be decreased when it is combined with Boceprevir.
BoceprevirThe metabolism of Boceprevir can be decreased when combined with Telaprevir.
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Telaprevir.
BortezomibThe metabolism of Telaprevir can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Telaprevir can be decreased when it is combined with Bosentan.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Telaprevir.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Telaprevir.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Telaprevir.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Telaprevir.
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Telaprevir.
BromazepamThe metabolism of Bromazepam can be decreased when combined with Telaprevir.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Telaprevir.
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Telaprevir.
BudesonideThe serum concentration of Telaprevir can be decreased when it is combined with Budesonide.
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Telaprevir.
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Telaprevir.
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Telaprevir.
BuprenorphineThe serum concentration of Telaprevir can be increased when it is combined with Buprenorphine.
BupropionThe metabolism of Bupropion can be decreased when combined with Telaprevir.
BuspironeThe metabolism of Buspirone can be decreased when combined with Telaprevir.
BuspironeThe serum concentration of Telaprevir can be increased when it is combined with Buspirone.
BusulfanThe metabolism of Busulfan can be decreased when combined with Telaprevir.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Telaprevir.
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Telaprevir.
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Telaprevir.
CaffeineThe metabolism of Caffeine can be decreased when combined with Telaprevir.
CaffeineThe serum concentration of Telaprevir can be increased when it is combined with Caffeine.
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Telaprevir.
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Telaprevir.
CanagliflozinThe serum concentration of Telaprevir can be increased when it is combined with Canagliflozin.
CandesartanThe serum concentration of Telaprevir can be increased when it is combined with Candesartan.
CaptoprilThe serum concentration of Telaprevir can be increased when it is combined with Captopril.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Telaprevir.
CarbamazepineThe serum concentration of Telaprevir can be decreased when it is combined with Carbamazepine.
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Telaprevir.
CariprazineThe metabolism of Cariprazine can be decreased when combined with Telaprevir.
CarvedilolThe metabolism of Carvedilol can be decreased when combined with Telaprevir.
CarvedilolThe serum concentration of Telaprevir can be increased when it is combined with Carvedilol.
CaspofunginThe serum concentration of Telaprevir can be increased when it is combined with Caspofungin.
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Telaprevir.
CeliprololThe metabolism of Celiprolol can be decreased when combined with Telaprevir.
CephalexinThe metabolism of Cephalexin can be decreased when combined with Telaprevir.
CeritinibThe serum concentration of Telaprevir can be increased when it is combined with Ceritinib.
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Telaprevir.
CevimelineThe metabolism of Cevimeline can be decreased when combined with Telaprevir.
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Telaprevir.
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Telaprevir.
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Telaprevir.
ChloroquineThe serum concentration of Telaprevir can be increased when it is combined with Chloroquine.
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Telaprevir.
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Telaprevir.
ChlorpromazineThe serum concentration of Telaprevir can be increased when it is combined with Chlorpromazine.
ChlorpropamideThe serum concentration of Telaprevir can be increased when it is combined with Chlorpropamide.
ChlorprothixeneThe serum concentration of Telaprevir can be increased when it is combined with Chlorprothixene.
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Telaprevir.
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Telaprevir.
CholesterolThe serum concentration of Telaprevir can be increased when it is combined with Cholesterol.
Cholic AcidThe serum concentration of Telaprevir can be decreased when it is combined with Cholic Acid.
CiclesonideThe serum concentration of Telaprevir can be decreased when it is combined with Ciclesonide.
CiclesonideThe serum concentration of Ciclesonide can be increased when it is combined with Telaprevir.
CilazaprilThe serum concentration of Telaprevir can be increased when it is combined with Cilazapril.
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Telaprevir.
CimetidineThe serum concentration of Telaprevir can be decreased when it is combined with Cimetidine.
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Telaprevir.
CiprofloxacinThe serum concentration of Telaprevir can be increased when it is combined with Ciprofloxacin.
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Telaprevir.
CitalopramThe metabolism of Citalopram can be decreased when combined with Telaprevir.
CitalopramThe serum concentration of Telaprevir can be increased when it is combined with Citalopram.
ClarithromycinThe therapeutic efficacy of Clarithromycin can be decreased when used in combination with Telaprevir.
ClarithromycinThe serum concentration of Telaprevir can be increased when it is combined with Clarithromycin.
ClemastineThe metabolism of Telaprevir can be decreased when combined with Clemastine.
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Telaprevir.
ClobazamThe metabolism of Clobazam can be decreased when combined with Telaprevir.
Clobetasol propionateThe serum concentration of Telaprevir can be decreased when it is combined with Clobetasol propionate.
Clobetasol propionateThe serum concentration of Clobetasol propionate can be increased when it is combined with Telaprevir.
ClocortoloneThe serum concentration of Telaprevir can be decreased when it is combined with Clocortolone.
ClocortoloneThe serum concentration of Clocortolone can be increased when it is combined with Telaprevir.
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Telaprevir.
ClofazimineThe serum concentration of Telaprevir can be increased when it is combined with Clofazimine.
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Telaprevir.
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Telaprevir.
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Telaprevir.
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Telaprevir.
ClonidineThe metabolism of Clonidine can be decreased when combined with Telaprevir.
ClopidogrelThe metabolism of Clopidogrel can be decreased when combined with Telaprevir.
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Telaprevir.
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Telaprevir.
ClotrimazoleThe metabolism of Telaprevir can be decreased when combined with Clotrimazole.
ClozapineThe metabolism of Clozapine can be decreased when combined with Telaprevir.
CobicistatThe serum concentration of Telaprevir can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Telaprevir.
CocaineThe metabolism of Cocaine can be decreased when combined with Telaprevir.
CodeineThe metabolism of Codeine can be decreased when combined with Telaprevir.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Telaprevir.
ColforsinThe serum concentration of Telaprevir can be increased when it is combined with Colforsin.
ConivaptanThe serum concentration of Telaprevir can be increased when it is combined with Conivaptan.
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be decreased when combined with Telaprevir.
Cortisone acetateThe serum concentration of Telaprevir can be decreased when it is combined with Cortisone acetate.
Cortisone acetateThe serum concentration of Cortisone acetate can be increased when it is combined with Telaprevir.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Telaprevir.
CrizotinibThe metabolism of Telaprevir can be decreased when combined with Crizotinib.
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Telaprevir.
CyclophosphamideThe risk or severity of adverse effects can be increased when Telaprevir is combined with Cyclophosphamide.
CyclophosphamideThe serum concentration of Telaprevir can be increased when it is combined with Cyclophosphamide.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Telaprevir.
CyclosporineThe metabolism of Telaprevir can be decreased when combined with Cyclosporine.
CytarabineThe metabolism of Cytarabine can be decreased when combined with Telaprevir.
DabrafenibThe serum concentration of Telaprevir can be decreased when it is combined with Dabrafenib.
DabrafenibThe metabolism of Dabrafenib can be decreased when combined with Telaprevir.
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Telaprevir.
DactinomycinThe serum concentration of Telaprevir can be increased when it is combined with Dactinomycin.
DantroleneThe metabolism of Dantrolene can be decreased when combined with Telaprevir.
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Telaprevir.
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Telaprevir.
DapsoneThe metabolism of Dapsone can be decreased when combined with Telaprevir.
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Telaprevir.
DarunavirThe serum concentration of Telaprevir can be decreased when it is combined with Darunavir.
DarunavirThe metabolism of Darunavir can be decreased when combined with Telaprevir.
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Telaprevir.
DasatinibThe serum concentration of Telaprevir can be increased when it is combined with Dasatinib.
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Telaprevir.
DaunorubicinThe serum concentration of Telaprevir can be decreased when it is combined with Daunorubicin.
DeferasiroxThe serum concentration of Telaprevir can be decreased when it is combined with Deferasirox.
DehydroepiandrosteroneThe serum concentration of Telaprevir can be decreased when it is combined with Dehydroepiandrosterone.
DehydroepiandrosteroneThe serum concentration of Dehydroepiandrosterone can be increased when it is combined with Telaprevir.
dehydroepiandrosterone sulfateThe serum concentration of Telaprevir can be decreased when it is combined with dehydroepiandrosterone sulfate.
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be increased when it is combined with Telaprevir.
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Telaprevir.
DelavirdineThe metabolism of Telaprevir can be decreased when combined with Delavirdine.
DesipramineThe serum concentration of Desipramine can be increased when it is combined with Telaprevir.
DesloratadineThe serum concentration of Telaprevir can be increased when it is combined with Desloratadine.
DesoximetasoneThe serum concentration of Telaprevir can be decreased when it is combined with Desoximetasone.
DesoximetasoneThe serum concentration of Desoximetasone can be increased when it is combined with Telaprevir.
Desoxycorticosterone acetateThe serum concentration of Telaprevir can be decreased when it is combined with Desoxycorticosterone acetate.
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be increased when it is combined with Telaprevir.
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Telaprevir.
DexamethasoneThe serum concentration of Telaprevir can be decreased when it is combined with Dexamethasone.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Telaprevir.
Dexamethasone isonicotinateThe serum concentration of Telaprevir can be decreased when it is combined with Dexamethasone isonicotinate.
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Telaprevir.
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Telaprevir.
DextromethorphanThe serum concentration of Telaprevir can be increased when it is combined with Dextromethorphan.
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Telaprevir.
DiazepamThe metabolism of Diazepam can be decreased when combined with Telaprevir.
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Telaprevir.
DiclofenacThe serum concentration of Telaprevir can be increased when it is combined with Diclofenac.
DienogestThe serum concentration of Dienogest can be increased when it is combined with Telaprevir.
DiflorasoneThe serum concentration of Telaprevir can be decreased when it is combined with Diflorasone.
DiflorasoneThe serum concentration of Diflorasone can be increased when it is combined with Telaprevir.
DifluocortoloneThe serum concentration of Telaprevir can be decreased when it is combined with Difluocortolone.
DifluocortoloneThe serum concentration of Difluocortolone can be increased when it is combined with Telaprevir.
DifluprednateThe serum concentration of Telaprevir can be decreased when it is combined with Difluprednate.
DifluprednateThe serum concentration of Difluprednate can be increased when it is combined with Telaprevir.
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Telaprevir.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Telaprevir.
DigoxinThe serum concentration of Telaprevir can be decreased when it is combined with Digoxin.
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Telaprevir.
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Telaprevir.
DihydroergotamineThe metabolism of Telaprevir can be decreased when combined with Dihydroergotamine.
DiltiazemThe metabolism of Telaprevir can be decreased when combined with Diltiazem.
DipyridamoleThe serum concentration of Telaprevir can be increased when it is combined with Dipyridamole.
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Telaprevir.
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Telaprevir.
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Telaprevir.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Telaprevir.
DolasetronThe metabolism of Dolasetron can be decreased when combined with Telaprevir.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Telaprevir.
DonepezilThe metabolism of Donepezil can be decreased when combined with Telaprevir.
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Telaprevir.
DosulepinThe serum concentration of Dosulepin can be increased when it is combined with Telaprevir.
DoxazosinThe serum concentration of Telaprevir can be increased when it is combined with Doxazosin.
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Telaprevir.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Telaprevir.
DoxorubicinThe serum concentration of Telaprevir can be decreased when it is combined with Doxorubicin.
DoxycyclineThe metabolism of Telaprevir can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Telaprevir.
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Telaprevir.
DronedaroneThe metabolism of Telaprevir can be decreased when combined with Dronedarone.
DrospirenoneThe serum concentration of Drospirenone can be increased when it is combined with Telaprevir.
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Telaprevir.
DyphyllineThe serum concentration of Dyphylline can be decreased when it is combined with Telaprevir.
EfavirenzThe serum concentration of Telaprevir can be decreased when it is combined with Efavirenz.
EfavirenzThe metabolism of Efavirenz can be decreased when combined with Telaprevir.
ElbasvirThe serum concentration of Telaprevir can be increased when it is combined with Elbasvir.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Telaprevir.
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Telaprevir.
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Telaprevir.
EnalaprilThe metabolism of Enalapril can be decreased when combined with Telaprevir.
EnalaprilThe serum concentration of Telaprevir can be increased when it is combined with Enalapril.
EnfuvirtideThe serum concentration of Enfuvirtide can be increased when it is combined with Telaprevir.
EnzalutamideThe serum concentration of Enzalutamide can be increased when it is combined with Telaprevir.
EnzalutamideThe serum concentration of Telaprevir can be decreased when it is combined with Enzalutamide.
EpinastineThe metabolism of Epinastine can be decreased when combined with Telaprevir.
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Telaprevir.
EquileninThe serum concentration of Telaprevir can be decreased when it is combined with Equilenin.
EquileninThe serum concentration of Equilenin can be increased when it is combined with Telaprevir.
EquilinThe serum concentration of Telaprevir can be decreased when it is combined with Equilin.
EquilinThe serum concentration of Equilin can be increased when it is combined with Telaprevir.
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Telaprevir.
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Telaprevir.
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Telaprevir.
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Telaprevir.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Telaprevir.
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Telaprevir.
ErythromycinThe metabolism of Telaprevir can be decreased when combined with Erythromycin.
EscitalopramThe serum concentration of Escitalopram can be decreased when it is combined with Telaprevir.
Eslicarbazepine acetateThe serum concentration of Telaprevir can be decreased when it is combined with Eslicarbazepine acetate.
EsmirtazapineThe serum concentration of Esmirtazapine can be increased when it is combined with Telaprevir.
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Telaprevir.
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Telaprevir.
EstradiolThe metabolism of Estradiol can be decreased when combined with Telaprevir.
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Telaprevir.
EstramustineThe metabolism of Estramustine can be decreased when combined with Telaprevir.
EstramustineThe serum concentration of Telaprevir can be increased when it is combined with Estramustine.
EstriolThe serum concentration of Telaprevir can be decreased when it is combined with Estriol.
EstroneThe serum concentration of Telaprevir can be decreased when it is combined with Estrone.
EstroneThe serum concentration of Estrone can be increased when it is combined with Telaprevir.
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Telaprevir.
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Telaprevir.
EthanolThe metabolism of Ethanol can be decreased when combined with Telaprevir.
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Telaprevir.
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Telaprevir.
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Telaprevir.
EtizolamThe serum concentration of Etizolam can be increased when it is combined with Telaprevir.
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Telaprevir.
EtoposideThe metabolism of Etoposide can be decreased when combined with Telaprevir.
EtoposideThe serum concentration of Telaprevir can be increased when it is combined with Etoposide.
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Telaprevir.
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Telaprevir.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Telaprevir.
ExemestaneThe metabolism of Exemestane can be decreased when combined with Telaprevir.
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Telaprevir.
FelbamateThe metabolism of Felbamate can be decreased when combined with Telaprevir.
FelodipineThe metabolism of Felodipine can be decreased when combined with Telaprevir.
FelodipineThe serum concentration of Telaprevir can be increased when it is combined with Felodipine.
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Telaprevir.
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Telaprevir.
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Telaprevir.
FexofenadineThe serum concentration of Telaprevir can be increased when it is combined with Fexofenadine.
FidaxomicinThe serum concentration of Telaprevir can be increased when it is combined with Fidaxomicin.
FinasterideThe metabolism of Finasteride can be decreased when combined with Telaprevir.
FingolimodThe metabolism of Fingolimod can be decreased when combined with Telaprevir.
FlecainideThe risk or severity of adverse effects can be increased when Telaprevir is combined with Flecainide.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Telaprevir.
FluconazoleThe metabolism of Telaprevir can be decreased when combined with Fluconazole.
FludrocortisoneThe serum concentration of Telaprevir can be decreased when it is combined with Fludrocortisone.
FludrocortisoneThe serum concentration of Fludrocortisone can be increased when it is combined with Telaprevir.
FlumethasoneThe serum concentration of Telaprevir can be decreased when it is combined with Flumethasone.
FlumethasoneThe serum concentration of Flumethasone can be increased when it is combined with Telaprevir.
FlunisolideThe serum concentration of Telaprevir can be decreased when it is combined with Flunisolide.
FlunisolideThe serum concentration of Flunisolide can be increased when it is combined with Telaprevir.
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Telaprevir.
Fluocinolone AcetonideThe serum concentration of Telaprevir can be decreased when it is combined with Fluocinolone Acetonide.
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be increased when it is combined with Telaprevir.
FluocinonideThe serum concentration of Telaprevir can be decreased when it is combined with Fluocinonide.
FluocinonideThe serum concentration of Fluocinonide can be increased when it is combined with Telaprevir.
FluocortoloneThe serum concentration of Telaprevir can be decreased when it is combined with Fluocortolone.
FluocortoloneThe serum concentration of Fluocortolone can be increased when it is combined with Telaprevir.
FluorometholoneThe serum concentration of Telaprevir can be decreased when it is combined with Fluorometholone.
FluorometholoneThe serum concentration of Fluorometholone can be increased when it is combined with Telaprevir.
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Telaprevir.
FluoxetineThe serum concentration of Telaprevir can be increased when it is combined with Fluoxetine.
FlupentixolThe serum concentration of Telaprevir can be increased when it is combined with Flupentixol.
FluphenazineThe serum concentration of Telaprevir can be increased when it is combined with Fluphenazine.
FluprednideneThe serum concentration of Telaprevir can be decreased when it is combined with Fluprednidene.
FluprednideneThe serum concentration of Fluprednidene can be increased when it is combined with Telaprevir.
FluprednisoloneThe serum concentration of Telaprevir can be decreased when it is combined with Fluprednisolone.
FluprednisoloneThe serum concentration of Fluprednisolone can be increased when it is combined with Telaprevir.
FlurandrenolideThe serum concentration of Telaprevir can be decreased when it is combined with Flurandrenolide.
FlurandrenolideThe serum concentration of Flurandrenolide can be increased when it is combined with Telaprevir.
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Telaprevir.
FlurazepamThe serum concentration of Telaprevir can be increased when it is combined with Flurazepam.
FlutamideThe metabolism of Flutamide can be decreased when combined with Telaprevir.
Fluticasone furoateThe serum concentration of Telaprevir can be decreased when it is combined with Fluticasone furoate.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Telaprevir.
Fluticasone PropionateThe serum concentration of Telaprevir can be decreased when it is combined with Fluticasone Propionate.
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Telaprevir.
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Telaprevir.
FluvoxamineThe metabolism of Telaprevir can be decreased when combined with Fluvoxamine.
FosamprenavirThe serum concentration of Telaprevir can be decreased when it is combined with Fosamprenavir.
FosamprenavirThe metabolism of Fosamprenavir can be decreased when combined with Telaprevir.
FosaprepitantThe serum concentration of Telaprevir can be increased when it is combined with Fosaprepitant.
FosphenytoinThe serum concentration of Telaprevir can be decreased when it is combined with Fosphenytoin.
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Telaprevir.
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Telaprevir.
Fusidic AcidThe serum concentration of Telaprevir can be increased when it is combined with Fusidic Acid.
GalantamineThe metabolism of Galantamine can be decreased when combined with Telaprevir.
GarlicThe serum concentration of Telaprevir can be decreased when it is combined with Garlic.
GefitinibThe metabolism of Gefitinib can be decreased when combined with Telaprevir.
GefitinibThe serum concentration of Telaprevir can be increased when it is combined with Gefitinib.
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Telaprevir.
GenisteinThe serum concentration of Telaprevir can be increased when it is combined with Genistein.
GlipizideThe metabolism of Glipizide can be decreased when combined with Telaprevir.
GlyburideThe metabolism of Glyburide can be decreased when combined with Telaprevir.
GlyburideThe serum concentration of Telaprevir can be increased when it is combined with Glyburide.
GlycerolThe serum concentration of Telaprevir can be increased when it is combined with Glycerol.
Gramicidin DThe serum concentration of Telaprevir can be increased when it is combined with Gramicidin D.
GranisetronThe metabolism of Granisetron can be decreased when combined with Telaprevir.
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Telaprevir.
GrepafloxacinThe serum concentration of Telaprevir can be increased when it is combined with Grepafloxacin.
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Telaprevir.
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Telaprevir.
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Telaprevir.
HaloperidolThe serum concentration of Telaprevir can be increased when it is combined with Haloperidol.
HalothaneThe metabolism of Halothane can be decreased when combined with Telaprevir.
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Telaprevir.
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Telaprevir.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Telaprevir.
HydrocortisoneThe serum concentration of Telaprevir can be increased when it is combined with Hydrocortisone.
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Telaprevir.
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Telaprevir.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Telaprevir.
IdelalisibThe serum concentration of Telaprevir can be increased when it is combined with Idelalisib.
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Telaprevir resulting in a loss in efficacy.
IloperidoneThe serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Telaprevir.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Telaprevir.
ImatinibThe metabolism of Telaprevir can be decreased when combined with Imatinib.
ImidafenacinThe serum concentration of Imidafenacin can be increased when it is combined with Telaprevir.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Telaprevir.
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Telaprevir.
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Telaprevir.
IndapamideThe metabolism of Indapamide can be decreased when combined with Telaprevir.
IndinavirThe metabolism of Indinavir can be decreased when combined with Telaprevir.
IndinavirThe serum concentration of Telaprevir can be decreased when it is combined with Indinavir.
IndomethacinThe serum concentration of Telaprevir can be increased when it is combined with Indomethacin.
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Telaprevir.
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be increased when Irinotecan is used in combination with Telaprevir.
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Telaprevir.
IsavuconazoniumThe metabolism of Telaprevir can be decreased when combined with Isavuconazonium.
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Telaprevir.
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Telaprevir.
IsradipineThe metabolism of Telaprevir can be decreased when combined with Isradipine.
ItraconazoleThe serum concentration of Itraconazole can be increased when it is combined with Telaprevir.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Telaprevir.
IvacaftorThe serum concentration of Telaprevir can be increased when it is combined with Ivacaftor.
IvermectinThe metabolism of Ivermectin can be decreased when combined with Telaprevir.
IvermectinThe serum concentration of Telaprevir can be increased when it is combined with Ivermectin.
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Telaprevir.
IxazomibThe metabolism of Ixazomib can be decreased when combined with Telaprevir.
KetamineThe metabolism of Ketamine can be decreased when combined with Telaprevir.
KetamineThe serum concentration of Telaprevir can be increased when it is combined with Ketamine.
KetazolamThe metabolism of Ketazolam can be decreased when combined with Telaprevir.
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Telaprevir.
KetoconazoleThe metabolism of Ketoconazole can be decreased when combined with Telaprevir.
KetoconazoleThe serum concentration of Telaprevir can be increased when it is combined with Ketoconazole.
LacosamideThe serum concentration of Lacosamide can be increased when it is combined with Telaprevir.
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Telaprevir.
LansoprazoleThe serum concentration of Telaprevir can be increased when it is combined with Lansoprazole.
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Telaprevir.
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Telaprevir.
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Telaprevir.
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Telaprevir.
LetrozoleThe metabolism of Letrozole can be decreased when combined with Telaprevir.
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Telaprevir.
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Telaprevir.
LevofloxacinThe serum concentration of Telaprevir can be increased when it is combined with Levofloxacin.
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Telaprevir.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Telaprevir.
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Telaprevir.
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Telaprevir.
LevothyroxineThe serum concentration of Telaprevir can be decreased when it is combined with Levothyroxine.
LidocaineThe risk or severity of adverse effects can be increased when Telaprevir is combined with Lidocaine.
LidocaineThe serum concentration of Telaprevir can be increased when it is combined with Lidocaine.
LiothyronineThe serum concentration of Telaprevir can be decreased when it is combined with Liothyronine.
LiotrixThe serum concentration of Telaprevir can be decreased when it is combined with Liotrix.
LisinoprilThe serum concentration of Telaprevir can be increased when it is combined with Lisinopril.
LisurideThe metabolism of Lisuride can be decreased when combined with Telaprevir.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Telaprevir.
LoperamideThe metabolism of Loperamide can be decreased when combined with Telaprevir.
LoperamideThe serum concentration of Telaprevir can be increased when it is combined with Loperamide.
LopinavirThe serum concentration of Telaprevir can be decreased when it is combined with Lopinavir.
LopinavirThe metabolism of Lopinavir can be decreased when combined with Telaprevir.
LoratadineThe metabolism of Loratadine can be decreased when combined with Telaprevir.
LoratadineThe serum concentration of Telaprevir can be increased when it is combined with Loratadine.
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Telaprevir.
LosartanThe metabolism of Losartan can be decreased when combined with Telaprevir.
LosartanThe serum concentration of Telaprevir can be increased when it is combined with Losartan.
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Telaprevir.
LovastatinThe metabolism of Telaprevir can be decreased when combined with Lovastatin.
LuliconazoleThe serum concentration of Telaprevir can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Telaprevir can be decreased when it is combined with Lumacaftor.
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Telaprevir.
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Telaprevir.
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Telaprevir.
MaprotilineThe serum concentration of Telaprevir can be increased when it is combined with Maprotiline.
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Telaprevir.
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Telaprevir.
MebendazoleThe serum concentration of Telaprevir can be increased when it is combined with Mebendazole.
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Telaprevir.
MedrysoneThe serum concentration of Telaprevir can be decreased when it is combined with Medrysone.
MedrysoneThe serum concentration of Medrysone can be increased when it is combined with Telaprevir.
MefloquineThe metabolism of Mefloquine can be decreased when combined with Telaprevir.
MefloquineThe serum concentration of Telaprevir can be increased when it is combined with Mefloquine.
Megestrol acetateThe serum concentration of Telaprevir can be increased when it is combined with Megestrol acetate.
MelengestrolThe serum concentration of Telaprevir can be decreased when it is combined with Melengestrol.
MelengestrolThe serum concentration of Melengestrol can be increased when it is combined with Telaprevir.
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Telaprevir.
MeprobamateThe serum concentration of Telaprevir can be increased when it is combined with Meprobamate.
MethadoneThe serum concentration of Methadone can be decreased when it is combined with Telaprevir.
MethadoneThe serum concentration of Telaprevir can be increased when it is combined with Methadone.
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Telaprevir.
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Telaprevir.
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Telaprevir.
MethylergometrineThe serum concentration of Methylergometrine can be increased when it is combined with Telaprevir.
MethylprednisoloneThe serum concentration of Telaprevir can be decreased when it is combined with Methylprednisolone.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Telaprevir.
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Telaprevir.
MetoprololThe serum concentration of Telaprevir can be increased when it is combined with Metoprolol.
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Telaprevir.
MexiletineThe metabolism of Mexiletine can be decreased when combined with Telaprevir.
MianserinThe metabolism of Mianserin can be decreased when combined with Telaprevir.
MibefradilThe metabolism of Mibefradil can be decreased when combined with Telaprevir.
MibefradilThe serum concentration of Telaprevir can be increased when it is combined with Mibefradil.
MiconazoleThe metabolism of Miconazole can be decreased when combined with Telaprevir.
MiconazoleThe serum concentration of Telaprevir can be increased when it is combined with Miconazole.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Telaprevir.
MidazolamThe serum concentration of Telaprevir can be decreased when it is combined with Midazolam.
MifepristoneThe serum concentration of Mifepristone can be increased when it is combined with Telaprevir.
MifepristoneThe metabolism of Telaprevir can be decreased when combined with Mifepristone.
MirabegronThe metabolism of Mirabegron can be decreased when combined with Telaprevir.
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Telaprevir.
MitomycinThe serum concentration of Telaprevir can be increased when it is combined with Mitomycin.
MitotaneThe serum concentration of Telaprevir can be decreased when it is combined with Mitotane.
MitoxantroneThe serum concentration of Telaprevir can be decreased when it is combined with Mitoxantrone.
ModafinilThe serum concentration of Telaprevir can be decreased when it is combined with Modafinil.
ModafinilThe metabolism of Modafinil can be decreased when combined with Telaprevir.
MometasoneThe serum concentration of Telaprevir can be decreased when it is combined with Mometasone.
MometasoneThe serum concentration of Mometasone can be increased when it is combined with Telaprevir.
MontelukastThe metabolism of Montelukast can be decreased when combined with Telaprevir.
MorphineThe metabolism of Morphine can be decreased when combined with Telaprevir.
MorphineThe serum concentration of Telaprevir can be increased when it is combined with Morphine.
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Telaprevir.
NafcillinThe serum concentration of Telaprevir can be decreased when it is combined with Nafcillin.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Telaprevir.
NaloxoneThe metabolism of Naloxone can be decreased when combined with Telaprevir.
NaltrexoneThe serum concentration of Telaprevir can be increased when it is combined with Naltrexone.
NaringeninThe serum concentration of Telaprevir can be increased when it is combined with Naringenin.
NateglinideThe metabolism of Nateglinide can be decreased when combined with Telaprevir.
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Telaprevir.
NefazodoneThe serum concentration of Telaprevir can be decreased when it is combined with Nefazodone.
NelfinavirThe metabolism of Nelfinavir can be decreased when combined with Telaprevir.
NelfinavirThe serum concentration of Telaprevir can be decreased when it is combined with Nelfinavir.
NeostigmineThe serum concentration of Telaprevir can be increased when it is combined with Neostigmine.
NetupitantThe serum concentration of Telaprevir can be increased when it is combined with Netupitant.
NevirapineThe serum concentration of Telaprevir can be decreased when it is combined with Nevirapine.
NevirapineThe metabolism of Nevirapine can be decreased when combined with Telaprevir.
NicardipineThe metabolism of Nicardipine can be decreased when combined with Telaprevir.
NicardipineThe serum concentration of Telaprevir can be increased when it is combined with Nicardipine.
NicotineThe metabolism of Nicotine can be decreased when combined with Telaprevir.
NifedipineThe metabolism of Nifedipine can be decreased when combined with Telaprevir.
NifedipineThe serum concentration of Telaprevir can be decreased when it is combined with Nifedipine.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Telaprevir.
NilotinibThe metabolism of Telaprevir can be decreased when combined with Nilotinib.
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Telaprevir.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Telaprevir.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Telaprevir.
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Telaprevir.
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Telaprevir.
NitrazepamThe serum concentration of Telaprevir can be increased when it is combined with Nitrazepam.
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Telaprevir.
NitrendipineThe serum concentration of Telaprevir can be increased when it is combined with Nitrendipine.
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Telaprevir.
NorethisteroneThe serum concentration of Telaprevir can be decreased when it is combined with Norethisterone.
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Telaprevir.
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Telaprevir.
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Telaprevir.
OlaparibThe metabolism of Telaprevir can be decreased when combined with Olaparib.
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Telaprevir.
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Telaprevir.
OmeprazoleThe serum concentration of Telaprevir can be increased when it is combined with Omeprazole.
OndansetronThe metabolism of Ondansetron can be decreased when combined with Telaprevir.
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Telaprevir.
OsimertinibThe serum concentration of Telaprevir can be increased when it is combined with Osimertinib.
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Telaprevir.
OxazepamThe metabolism of Oxazepam can be decreased when combined with Telaprevir.
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Telaprevir.
OxycodoneThe risk or severity of adverse effects can be increased when Telaprevir is combined with Oxycodone.
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Telaprevir.
P-NitrophenolThe serum concentration of Telaprevir can be increased when it is combined with P-Nitrophenol.
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Telaprevir.
PaclitaxelThe serum concentration of Telaprevir can be increased when it is combined with Paclitaxel.
PalbociclibThe serum concentration of Telaprevir can be increased when it is combined with Palbociclib.
Palmitic AcidThe serum concentration of Telaprevir can be increased when it is combined with Palmitic Acid.
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Telaprevir.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Telaprevir.
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Telaprevir.
PantoprazoleThe serum concentration of Telaprevir can be increased when it is combined with Pantoprazole.
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Telaprevir.
ParamethasoneThe serum concentration of Telaprevir can be decreased when it is combined with Paramethasone.
ParamethasoneThe serum concentration of Paramethasone can be increased when it is combined with Telaprevir.
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Telaprevir.
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Telaprevir.
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Telaprevir.
ParoxetineThe serum concentration of Telaprevir can be increased when it is combined with Paroxetine.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Telaprevir.
PentamidineThe metabolism of Pentamidine can be decreased when combined with Telaprevir.
PentobarbitalThe serum concentration of Telaprevir can be decreased when it is combined with Pentobarbital.
PerampanelThe metabolism of Perampanel can be decreased when combined with Telaprevir.
PergolideThe metabolism of Pergolide can be decreased when combined with Telaprevir.
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Telaprevir.
PerindoprilThe serum concentration of Telaprevir can be increased when it is combined with Perindopril.
PermethrinThe metabolism of Permethrin can be decreased when combined with Telaprevir.
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Telaprevir.
PethidineThe risk or severity of adverse effects can be increased when Telaprevir is combined with Pethidine.
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Telaprevir.
PhenobarbitalThe serum concentration of Telaprevir can be decreased when it is combined with Phenobarbital.
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Telaprevir.
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Telaprevir.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Telaprevir.
PhenytoinThe serum concentration of Telaprevir can be decreased when it is combined with Phenytoin.
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Telaprevir.
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Telaprevir.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Telaprevir.
PinacidilThe metabolism of Pinacidil can be decreased when combined with Telaprevir.
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Telaprevir.
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Telaprevir.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Telaprevir.
Platelet Activating FactorThe serum concentration of Telaprevir can be decreased when it is combined with Platelet Activating Factor.
PodofiloxThe metabolism of Podofilox can be decreased when combined with Telaprevir.
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Telaprevir.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Telaprevir.
PosaconazoleThe serum concentration of Posaconazole can be increased when it is combined with Telaprevir.
PranlukastThe serum concentration of Pranlukast can be increased when it is combined with Telaprevir.
PrasugrelThe serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Telaprevir resulting in a loss in efficacy.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Telaprevir.
PrazepamThe metabolism of Prazepam can be decreased when combined with Telaprevir.
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Telaprevir.
PrazosinThe serum concentration of Telaprevir can be increased when it is combined with Prazosin.
PrednicarbateThe serum concentration of Telaprevir can be decreased when it is combined with Prednicarbate.
PrednicarbateThe serum concentration of Prednicarbate can be increased when it is combined with Telaprevir.
PrednisoloneThe serum concentration of Telaprevir can be decreased when it is combined with Prednisolone.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Telaprevir.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Telaprevir.
PregnenoloneThe serum concentration of Telaprevir can be decreased when it is combined with Pregnenolone.
PregnenoloneThe serum concentration of Pregnenolone can be increased when it is combined with Telaprevir.
PrimaquineThe metabolism of Primaquine can be decreased when combined with Telaprevir.
PrimidoneThe serum concentration of Telaprevir can be decreased when it is combined with Primidone.
ProbenecidThe serum concentration of Telaprevir can be increased when it is combined with Probenecid.
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Telaprevir.
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Telaprevir.
ProgesteroneThe serum concentration of Telaprevir can be decreased when it is combined with Progesterone.
ProguanilThe metabolism of Proguanil can be decreased when combined with Telaprevir.
PromazineThe metabolism of Promazine can be decreased when combined with Telaprevir.
PromethazineThe serum concentration of Telaprevir can be increased when it is combined with Promethazine.
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Telaprevir.
PropofolThe metabolism of Propofol can be decreased when combined with Telaprevir.
PropranololThe metabolism of Propranolol can be decreased when combined with Telaprevir.
PropranololThe serum concentration of Telaprevir can be increased when it is combined with Propranolol.
ProtriptylineThe serum concentration of Protriptyline can be increased when it is combined with Telaprevir.
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Telaprevir.
QuazepamThe metabolism of Quazepam can be decreased when combined with Telaprevir.
QuercetinThe serum concentration of Telaprevir can be increased when it is combined with Quercetin.
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Telaprevir.
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Telaprevir.
QuinacrineThe serum concentration of Telaprevir can be increased when it is combined with Quinacrine.
QuinidineThe risk or severity of adverse effects can be increased when Telaprevir is combined with Quinidine.
QuinidineThe serum concentration of Telaprevir can be increased when it is combined with Quinidine.
QuinineThe metabolism of Quinine can be decreased when combined with Telaprevir.
QuinineThe serum concentration of Telaprevir can be increased when it is combined with Quinine.
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Telaprevir.
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Telaprevir.
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Telaprevir.
RanitidineThe serum concentration of Telaprevir can be increased when it is combined with Ranitidine.
RanolazineThe serum concentration of Telaprevir can be increased when it is combined with Ranolazine.
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Telaprevir.
ReboxetineThe serum concentration of Telaprevir can be increased when it is combined with Reboxetine.
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Telaprevir.
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Telaprevir.
ReserpineThe serum concentration of Telaprevir can be decreased when it is combined with Reserpine.
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Telaprevir.
RifabutinThe serum concentration of Telaprevir can be decreased when it is combined with Rifabutin.
RifabutinThe metabolism of Rifabutin can be decreased when combined with Telaprevir.
RifampicinThe serum concentration of Telaprevir can be decreased when it is combined with Rifampicin.
RifampicinThe metabolism of Rifampicin can be decreased when combined with Telaprevir.
RifapentineThe serum concentration of Telaprevir can be decreased when it is combined with Rifapentine.
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Telaprevir.
RimexoloneThe serum concentration of Telaprevir can be decreased when it is combined with Rimexolone.
RimexoloneThe serum concentration of Rimexolone can be increased when it is combined with Telaprevir.
RimonabantThe metabolism of Rimonabant can be decreased when combined with Telaprevir.
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Telaprevir.
RisperidoneThe metabolism of Risperidone can be decreased when combined with Telaprevir.
RitonavirThe serum concentration of Telaprevir can be decreased when it is combined with Ritonavir.
RitonavirThe metabolism of Ritonavir can be decreased when combined with Telaprevir.
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Telaprevir.
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Telaprevir.
RolapitantThe metabolism of Rolapitant can be decreased when combined with Telaprevir.
RolapitantThe serum concentration of Telaprevir can be increased when it is combined with Rolapitant.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Telaprevir.
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Telaprevir.
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Telaprevir.
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Telaprevir.
RotigotineThe metabolism of Rotigotine can be decreased when combined with Telaprevir.
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Telaprevir.
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Telaprevir.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Telaprevir.
SaquinavirThe metabolism of Saquinavir can be decreased when combined with Telaprevir.
SaquinavirThe serum concentration of Telaprevir can be decreased when it is combined with Saquinavir.
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Telaprevir.
ScopolamineThe serum concentration of Telaprevir can be increased when it is combined with Scopolamine.
SelegilineThe metabolism of Selegiline can be decreased when combined with Telaprevir.
SelegilineThe serum concentration of Telaprevir can be increased when it is combined with Selegiline.
SelexipagThe metabolism of Selexipag can be decreased when combined with Telaprevir.
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Telaprevir.
SertindoleThe metabolism of Sertindole can be decreased when combined with Telaprevir.
SertralineThe metabolism of Sertraline can be decreased when combined with Telaprevir.
SertralineThe serum concentration of Telaprevir can be increased when it is combined with Sertraline.
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Telaprevir.
SibutramineThe metabolism of Sibutramine can be decreased when combined with Telaprevir.
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Telaprevir.
SildenafilThe metabolism of Telaprevir can be decreased when combined with Sildenafil.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Telaprevir.
SiltuximabThe serum concentration of Telaprevir can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Telaprevir can be increased when it is combined with Simeprevir.
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Telaprevir.
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Telaprevir.
SirolimusThe serum concentration of Telaprevir can be decreased when it is combined with Sirolimus.
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Telaprevir.
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Telaprevir.
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Telaprevir.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Telaprevir.
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Telaprevir.
SpironolactoneThe serum concentration of Telaprevir can be increased when it is combined with Spironolactone.
St. John's WortThe metabolism of Telaprevir can be increased when combined with St. John's Wort.
StaurosporineThe serum concentration of Telaprevir can be increased when it is combined with Staurosporine.
StiripentolThe serum concentration of Telaprevir can be increased when it is combined with Stiripentol.
StreptozocinThe serum concentration of Telaprevir can be decreased when it is combined with Streptozocin.
SufentanilThe metabolism of Sufentanil can be decreased when combined with Telaprevir.
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Telaprevir.
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Telaprevir.
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Telaprevir.
SulfinpyrazoneThe serum concentration of Telaprevir can be increased when it is combined with Sulfinpyrazone.
SulfisoxazoleThe metabolism of Telaprevir can be decreased when combined with Sulfisoxazole.
SumatriptanThe serum concentration of Telaprevir can be increased when it is combined with Sumatriptan.
SunitinibThe metabolism of Sunitinib can be decreased when combined with Telaprevir.
SunitinibThe serum concentration of Telaprevir can be increased when it is combined with Sunitinib.
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Telaprevir.
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Telaprevir.
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Telaprevir.
TacrineThe serum concentration of Telaprevir can be increased when it is combined with Tacrine.
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Telaprevir.
TacrolimusThe serum concentration of Telaprevir can be decreased when it is combined with Tacrolimus.
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Telaprevir.
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Telaprevir.
TamoxifenThe serum concentration of Telaprevir can be decreased when it is combined with Tamoxifen.
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Telaprevir.
TasimelteonThe serum concentration of Tasimelteon can be increased when it is combined with Telaprevir.
TasosartanThe metabolism of Tasosartan can be decreased when combined with Telaprevir.
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Telaprevir.
Taurocholic AcidThe serum concentration of Telaprevir can be increased when it is combined with Taurocholic Acid.
TelithromycinThe serum concentration of Telaprevir can be increased when it is combined with Telithromycin.
TelithromycinThe metabolism of Telithromycin can be decreased when combined with Telaprevir.
TelmisartanThe serum concentration of Telaprevir can be increased when it is combined with Telmisartan.
TemazepamThe metabolism of Temazepam can be decreased when combined with Telaprevir.
TemsirolimusThe risk or severity of adverse effects can be increased when Telaprevir is combined with Temsirolimus.
TemsirolimusThe serum concentration of Telaprevir can be increased when it is combined with Temsirolimus.
TeniposideThe metabolism of Teniposide can be decreased when combined with Telaprevir.
TenofovirThe serum concentration of Tenofovir can be increased when it is combined with Telaprevir.
TerazosinThe serum concentration of Telaprevir can be increased when it is combined with Terazosin.
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Telaprevir.
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Telaprevir.
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Telaprevir.
TesmilifeneThe serum concentration of Telaprevir can be decreased when it is combined with Tesmilifene.
TestosteroneThe metabolism of Testosterone can be decreased when combined with Telaprevir.
TestosteroneThe serum concentration of Telaprevir can be increased when it is combined with Testosterone.
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Telaprevir.
TheophyllineThe serum concentration of Theophylline can be decreased when it is combined with Telaprevir.
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Telaprevir.
TiagabineThe metabolism of Tiagabine can be decreased when combined with Telaprevir.
TianeptineThe serum concentration of Tianeptine can be increased when it is combined with Telaprevir.
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Telaprevir resulting in a loss in efficacy.
TicagrelorThe serum concentration of Telaprevir can be increased when it is combined with Ticagrelor.
TiclopidineThe metabolism of Telaprevir can be decreased when combined with Ticlopidine.
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Telaprevir.
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Telaprevir.
TipranavirThe serum concentration of Telaprevir can be decreased when it is combined with Tipranavir.
TipranavirThe metabolism of Tipranavir can be decreased when combined with Telaprevir.
TixocortolThe serum concentration of Telaprevir can be decreased when it is combined with Tixocortol.
TixocortolThe serum concentration of Tixocortol can be increased when it is combined with Telaprevir.
TocilizumabThe serum concentration of Telaprevir can be decreased when it is combined with Tocilizumab.
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Telaprevir.
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Telaprevir.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Telaprevir.
ToremifeneThe risk or severity of adverse effects can be increased when Telaprevir is combined with Toremifene.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Telaprevir.
TramadolThe serum concentration of Tramadol can be increased when it is combined with Telaprevir.
Trastuzumab emtansineThe serum concentration of the active metabolites of Trastuzumab emtansine can be increased when Trastuzumab emtansine is used in combination with Telaprevir.
TrazodoneThe serum concentration of Trazodone can be increased when it is combined with Telaprevir.
TrazodoneThe serum concentration of Telaprevir can be decreased when it is combined with Trazodone.
TretinoinThe metabolism of Tretinoin can be decreased when combined with Telaprevir.
TriamcinoloneThe serum concentration of Telaprevir can be decreased when it is combined with Triamcinolone.
TriamcinoloneThe serum concentration of Triamcinolone can be increased when it is combined with Telaprevir.
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Telaprevir.
TrifluoperazineThe serum concentration of Telaprevir can be increased when it is combined with Trifluoperazine.
TriflupromazineThe serum concentration of Telaprevir can be increased when it is combined with Triflupromazine.
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Telaprevir.
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Telaprevir.
TrimethoprimThe serum concentration of Telaprevir can be decreased when it is combined with Trimethoprim.
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Telaprevir.
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Telaprevir.
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Telaprevir.
TroleandomycinThe serum concentration of Telaprevir can be increased when it is combined with Troleandomycin.
UdenafilThe metabolism of Udenafil can be decreased when combined with Telaprevir.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Telaprevir.
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Telaprevir.
VandetanibThe metabolism of Vandetanib can be decreased when combined with Telaprevir.
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Telaprevir.
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Telaprevir.
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Telaprevir.
VenlafaxineThe metabolism of Telaprevir can be decreased when combined with Venlafaxine.
VerapamilThe metabolism of Telaprevir can be decreased when combined with Verapamil.
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Telaprevir.
VilanterolThe metabolism of Vilanterol can be decreased when combined with Telaprevir.
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Telaprevir.
VinblastineThe metabolism of Vinblastine can be decreased when combined with Telaprevir.
VinblastineThe serum concentration of Telaprevir can be decreased when it is combined with Vinblastine.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Telaprevir.
VincristineThe serum concentration of Telaprevir can be decreased when it is combined with Vincristine.
VindesineThe serum concentration of Vindesine can be increased when it is combined with Telaprevir.
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Telaprevir.
VinorelbineThe serum concentration of Telaprevir can be increased when it is combined with Vinorelbine.
VismodegibThe metabolism of Vismodegib can be decreased when combined with Telaprevir.
VorapaxarThe serum concentration of Vorapaxar can be increased when it is combined with Telaprevir.
VoriconazoleThe serum concentration of Telaprevir can be increased when it is combined with Voriconazole.
VoriconazoleThe metabolism of Voriconazole can be decreased when combined with Telaprevir.
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Telaprevir.
WarfarinThe serum concentration of Warfarin can be decreased when it is combined with Telaprevir.
YohimbineThe metabolism of Yohimbine can be decreased when combined with Telaprevir.
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Telaprevir.
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Telaprevir.
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Telaprevir.
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Telaprevir.
ZileutonThe metabolism of Zileuton can be decreased when combined with Telaprevir.
ZimelidineThe serum concentration of Telaprevir can be increased when it is combined with Zimelidine.
ZiprasidoneThe metabolism of Telaprevir can be decreased when combined with Ziprasidone.
ZolpidemThe serum concentration of Zolpidem can be decreased when it is combined with Telaprevir.
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Telaprevir.
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Telaprevir.
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Telaprevir.
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Telaprevir.
Food Interactions
  • St. John's wort is a CYP3A4 inducer which will decrease levels of telaprevir.

Targets

Kind
Protein
Organism
Hepatitis C virus
Pharmacological action
yes
Actions
inhibitor
General Function:
Serine-type peptidase activity
Specific Function:
Not Available
Gene Name:
NS3/4A
Uniprot ID:
B0B3C9
Molecular Weight:
72789.28 Da
References
  1. Liu-Young G, Kozal MJ: Hepatitis C protease and polymerase inhibitors in development. AIDS Patient Care STDS. 2008 Jun;22(6):449-57. doi: 10.1089/apc.2007.0199. [PubMed:18479202 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Kim JJ, Culley CM, Mohammad RA: Telaprevir: an oral protease inhibitor for hepatitis C virus infection. Am J Health Syst Pharm. 2012 Jan 1;69(1):19-33. doi: 10.2146/ajhp110123. [PubMed:22180548 ]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Toxic substance binding
Specific Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Gene Name:
ALB
Uniprot ID:
P02768
Molecular Weight:
69365.94 Da
References
  1. Garg V, Kauffman RS, Beaumont M, van Heeswijk RP: Telaprevir: pharmacokinetics and drug interactions. Antivir Ther. 2012;17(7):1211-21. doi: 10.3851/IMP2356. Epub 2012 Sep 7. [PubMed:22954756 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Not Available
Specific Function:
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Gene Name:
ORM1
Uniprot ID:
P02763
Molecular Weight:
23511.38 Da
References
  1. Garg V, Kauffman RS, Beaumont M, van Heeswijk RP: Telaprevir: pharmacokinetics and drug interactions. Antivir Ther. 2012;17(7):1211-21. doi: 10.3851/IMP2356. Epub 2012 Sep 7. [PubMed:22954756 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Kiang TK, Wilby KJ, Ensom MH: Telaprevir: clinical pharmacokinetics, pharmacodynamics, and drug-drug interactions. Clin Pharmacokinet. 2013 Jul;52(7):487-510. doi: 10.1007/s40262-013-0053-x. [PubMed:23553423 ]
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Drug created on November 18, 2007 11:25 / Updated on September 26, 2016 02:14