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Identification
NameSertindole
Accession NumberDB06144
TypeSmall Molecule
GroupsApproved, Withdrawn
DescriptionSertindole, a neuroleptic, is one of the newer antipsychotic medications available. Serdolect is developed by the Danish pharmaceutical company H. Lundbeck. Like the other atypical antipsychotics, it has activity at dopamine and serotonin receptors in the brain. It is used in the treatment of schizophrenia. It is classified chemically as a phenylindole derivative. It was first marketed in 1996 in several European countries before being withdrawn two years later because of numerous cardiac adverse effects. It has once again been approved and should soon be available on the French and Australian market.
Structure
Thumb
Synonyms
1-[2-[4-[5-chloro-1-(4-Fluorophenyl)-indol-3-yl]-1-piperidyl]ethyl]imidazolidin-2-one
Serdolect
SerLect
Sertindol
Sertindole
Sertindolum
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
SerdolectNot Available
SerlectNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIGVV4Z879SP
CAS number106516-24-9
WeightAverage: 440.941
Monoisotopic: 440.177917386
Chemical FormulaC24H26ClFN4O
InChI KeyInChIKey=GZKLJWGUPQBVJQ-UHFFFAOYSA-N
InChI
InChI=1S/C24H26ClFN4O/c25-18-1-6-23-21(15-18)22(16-30(23)20-4-2-19(26)3-5-20)17-7-10-28(11-8-17)13-14-29-12-9-27-24(29)31/h1-6,15-17H,7-14H2,(H,27,31)
IUPAC Name
1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]piperidin-1-yl}ethyl)imidazolidin-2-one
SMILES
FC1=CC=C(C=C1)N1C=C(C2CCN(CCN3CCNC3=O)CC2)C2=C1C=CC(Cl)=C2
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenylpyrroles. These are polycyclic aromatic compounds containing a benzene ring linked to a pyrrole ring through a CC or CN bond.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassPyrroles
Sub ClassSubstituted pyrroles
Direct ParentPhenylpyrroles
Alternative Parents
Substituents
  • 1-phenylpyrrole
  • Indole or derivatives
  • Indole
  • Aralkylamine
  • Halobenzene
  • Fluorobenzene
  • Chlorobenzene
  • Benzenoid
  • Piperidine
  • Imidazolidinone
  • Monocyclic benzene moiety
  • Aryl halide
  • Aryl fluoride
  • Aryl chloride
  • Heteroaromatic compound
  • Imidazolidine
  • Urea
  • Tertiary aliphatic amine
  • Tertiary amine
  • Azacycle
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organofluoride
  • Organochloride
  • Organohalogen compound
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationUsed in the treatment of schizophrenia.
PharmacodynamicsSertindole is an atypical antipsychotic at least as effective as haloperidol and risperidone in the treatment of neuroleptic-responsive schizophrenia. Sertindole improves negative symptoms, and is also effective for the treatment of neuroleptic-resistant schizophrenia. Sertindole is generally well tolerated and is associated with a low rate of extrapyramidal symptoms (EPS).
Mechanism of actionSertindole is an antipsychotic drug with affinity for dopamine D2, serotonin 5-HT2A and 5-HT2C, and alpha1-adrenoreceptors. Preclinical studies suggest that sertindole acts preferentially on limbic and cortical dopaminergic neurons and clinical trials have confirmed that sertindole is effective at a low dopamine D2 occupancy level.
Related Articles
AbsorptionOrally available.
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Hepatic. Sertindole is metabolized by cytochrome P450 isoenzymes CYP 2D6 and CYP 3A4.

Route of eliminationNot Available
Half life3 days
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.9781
Caco-2 permeable-0.7081
P-glycoprotein substrateSubstrate0.683
P-glycoprotein inhibitor IInhibitor0.903
P-glycoprotein inhibitor IIInhibitor0.7529
Renal organic cation transporterInhibitor0.6044
CYP450 2C9 substrateNon-substrate0.7898
CYP450 2D6 substrateSubstrate0.8919
CYP450 3A4 substrateSubstrate0.6803
CYP450 1A2 substrateInhibitor0.7945
CYP450 2C9 inhibitorInhibitor0.5
CYP450 2D6 inhibitorNon-inhibitor0.6155
CYP450 2C19 inhibitorInhibitor0.624
CYP450 3A4 inhibitorInhibitor0.5802
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.8995
Ames testNon AMES toxic0.6144
CarcinogenicityNon-carcinogens0.8988
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.5452 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Strong inhibitor0.8038
hERG inhibition (predictor II)Inhibitor0.9186
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.00963 mg/mLALOGPS
logP4.29ALOGPS
logP3.77ChemAxon
logS-4.7ALOGPS
pKa (Strongest Acidic)14.36ChemAxon
pKa (Strongest Basic)8.59ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area40.51 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity131.77 m3·mol-1ChemAxon
Polarizability47.17 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis ReferenceNot Available
General References
  1. Kane JM, Tamminga CA: Sertindole (Serdolect): preclinical and clinical findings of a new atypical antipsychotic. Expert Opin Investig Drugs. 1997 Nov;6(11):1729-41. [PubMed:15989577 ]
  2. Lewis R, Bagnall AM, Leitner M: Sertindole for schizophrenia. Cochrane Database Syst Rev. 2005 Jul 20;(3):CD001715. [PubMed:16034864 ]
  3. Perquin LN: Treatment with the new antipsychotic sertindole for late-occurring undesirable movement effects. Int Clin Psychopharmacol. 2005 Nov;20(6):335-8. [PubMed:16192844 ]
  4. Murdoch D, Keating GM: Sertindole : a review of its use in schizophrenia. CNS Drugs. 2006;20(3):233-55. [PubMed:16529528 ]
  5. Authors unspecified: Sertindole: new drug. Another "atypical" neuroleptic; QT prolongation. Prescrire Int. 2007 Apr;16(88):59-62. [PubMed:17458045 ]
  6. Lindstrom E, Levander S: Sertindole: efficacy and safety in schizophrenia. Expert Opin Pharmacother. 2006 Sep;7(13):1825-34. [PubMed:16925508 ]
  7. Hertel P: Comparing sertindole to other new generation antipsychotics on preferential dopamine output in limbic versus striatal projection regions: mechanism of action. Synapse. 2006 Dec 1;60(7):543-52. [PubMed:16952163 ]
External Links
ATC CodesN05AE03
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
Interactions
Drug Interactions
Drug
3,4-MethylenedioxyamphetamineSertindole may decrease the stimulatory activities of 3,4-Methylenedioxyamphetamine.
3,4-MethylenedioxymethamphetamineSertindole may decrease the stimulatory activities of 3,4-Methylenedioxymethamphetamine.
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Sertindole.
AbirateroneThe metabolism of Sertindole can be decreased when combined with Abiraterone.
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Sertindole.
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Sertindole.
adipiplonThe risk or severity of adverse effects can be increased when Sertindole is combined with adipiplon.
AgomelatineThe risk or severity of adverse effects can be increased when Sertindole is combined with Agomelatine.
AlfaxaloneThe risk or severity of adverse effects can be increased when Sertindole is combined with Alfaxalone.
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Sertindole.
AlmotriptanThe risk or severity of adverse effects can be increased when Almotriptan is combined with Sertindole.
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Sertindole.
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Sertindole.
AmiodaroneThe metabolism of Sertindole can be decreased when combined with Amiodarone.
AmisulprideThe risk or severity of adverse effects can be increased when Sertindole is combined with Amisulpride.
AmitriptylineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Sertindole.
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Sertindole.
AmoxapineThe risk or severity of adverse effects can be increased when Sertindole is combined with Amoxapine.
AmperozideThe risk or severity of adverse effects can be increased when Sertindole is combined with Amperozide.
AmphetamineSertindole may decrease the stimulatory activities of Amphetamine.
AprepitantThe serum concentration of Sertindole can be increased when it is combined with Aprepitant.
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Sertindole.
ArtemetherThe metabolism of Sertindole can be decreased when combined with Artemether.
ArticaineThe risk or severity of adverse effects can be increased when Sertindole is combined with Articaine.
AsenapineThe risk or severity of adverse effects can be increased when Sertindole is combined with Asenapine.
AtazanavirThe metabolism of Sertindole can be decreased when combined with Atazanavir.
AtomoxetineThe metabolism of Sertindole can be decreased when combined with Atomoxetine.
AzaperoneThe risk or severity of adverse effects can be increased when Sertindole is combined with Azaperone.
AzelastineSertindole may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Sertindole.
BaclofenThe risk or severity of adverse effects can be increased when Sertindole is combined with Baclofen.
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Sertindole.
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Sertindole.
BenzphetamineSertindole may decrease the stimulatory activities of Benzphetamine.
Benzyl alcoholThe risk or severity of adverse effects can be increased when Sertindole is combined with Benzyl alcohol.
BetaxololThe metabolism of Sertindole can be decreased when combined with Betaxolol.
BexaroteneThe serum concentration of Sertindole can be decreased when it is combined with Bexarotene.
BoceprevirThe metabolism of Sertindole can be decreased when combined with Boceprevir.
BortezomibThe metabolism of Sertindole can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Sertindole can be decreased when it is combined with Bosentan.
BrexpiprazoleThe risk or severity of adverse effects can be increased when Sertindole is combined with Brexpiprazole.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Sertindole.
BrimonidineThe risk or severity of adverse effects can be increased when Sertindole is combined with Brimonidine.
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Sertindole.
BromocriptineThe risk or severity of adverse effects can be increased when Bromocriptine is combined with Sertindole.
BrompheniramineThe risk or severity of adverse effects can be increased when Sertindole is combined with Brompheniramine.
BrotizolamThe risk or severity of adverse effects can be increased when Sertindole is combined with Brotizolam.
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Sertindole.
BuprenorphineThe risk or severity of adverse effects can be increased when Buprenorphine is combined with Sertindole.
BupropionThe metabolism of Sertindole can be decreased when combined with Bupropion.
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Sertindole.
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Sertindole.
ButacaineThe risk or severity of adverse effects can be increased when Sertindole is combined with Butacaine.
ButalbitalThe risk or severity of adverse effects can be increased when Sertindole is combined with Butalbital.
ButambenThe risk or severity of adverse effects can be increased when Sertindole is combined with Butamben.
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Sertindole.
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Sertindole.
CabergolineThe risk or severity of adverse effects can be increased when Cabergoline is combined with Sertindole.
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Sertindole.
CarbinoxamineThe risk or severity of adverse effects can be increased when Sertindole is combined with Carbinoxamine.
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Sertindole.
CarisoprodolThe risk or severity of adverse effects can be increased when Sertindole is combined with Carisoprodol.
CelecoxibThe metabolism of Sertindole can be decreased when combined with Celecoxib.
CeritinibThe serum concentration of Sertindole can be increased when it is combined with Ceritinib.
CetirizineThe risk or severity of adverse effects can be increased when Sertindole is combined with Cetirizine.
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Sertindole.
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Sertindole.
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Sertindole.
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Sertindole.
ChloroquineThe metabolism of Sertindole can be decreased when combined with Chloroquine.
ChlorphenamineThe risk or severity of adverse effects can be increased when Sertindole is combined with Chlorphenamine.
ChlorphentermineSertindole may decrease the stimulatory activities of Chlorphentermine.
ChlorpromazineThe metabolism of Sertindole can be decreased when combined with Chlorpromazine.
ChlorpromazineThe risk or severity of adverse effects can be increased when Sertindole is combined with Chlorpromazine.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Sertindole.
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Sertindole is combined with Chlorzoxazone.
CholecalciferolThe metabolism of Sertindole can be decreased when combined with Cholecalciferol.
CimetidineThe metabolism of Sertindole can be decreased when combined with Cimetidine.
CinacalcetThe metabolism of Sertindole can be decreased when combined with Cinacalcet.
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Sertindole.
CitalopramThe risk or severity of adverse effects can be increased when Sertindole is combined with Citalopram.
ClarithromycinThe metabolism of Sertindole can be decreased when combined with Clarithromycin.
ClemastineThe metabolism of Sertindole can be decreased when combined with Clemastine.
ClemastineThe risk or severity of adverse effects can be increased when Sertindole is combined with Clemastine.
ClidiniumThe risk or severity of adverse effects can be increased when Sertindole is combined with Clidinium.
ClobazamThe metabolism of Sertindole can be decreased when combined with Clobazam.
ClobazamThe risk or severity of adverse effects can be increased when Sertindole is combined with Clobazam.
clomethiazoleThe risk or severity of adverse effects can be increased when Sertindole is combined with clomethiazole.
ClomipramineThe risk or severity of adverse effects can be increased when Sertindole is combined with Clomipramine.
ClonazepamThe risk or severity of adverse effects can be increased when Sertindole is combined with Clonazepam.
ClonidineThe risk or severity of adverse effects can be increased when Sertindole is combined with Clonidine.
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Sertindole.
ClotrimazoleThe metabolism of Sertindole can be decreased when combined with Clotrimazole.
ClozapineThe metabolism of Sertindole can be decreased when combined with Clozapine.
ClozapineThe risk or severity of adverse effects can be increased when Sertindole is combined with Clozapine.
CobicistatThe serum concentration of Sertindole can be increased when it is combined with Cobicistat.
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Sertindole.
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Sertindole.
ConivaptanThe serum concentration of Sertindole can be increased when it is combined with Conivaptan.
CrizotinibThe metabolism of Sertindole can be decreased when combined with Crizotinib.
CyclizineThe risk or severity of adverse effects can be increased when Sertindole is combined with Cyclizine.
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Sertindole.
CyclosporineThe metabolism of Sertindole can be decreased when combined with Cyclosporine.
CyproheptadineThe risk or severity of adverse effects can be increased when Sertindole is combined with Cyproheptadine.
DabrafenibThe serum concentration of Sertindole can be decreased when it is combined with Dabrafenib.
DantroleneThe risk or severity of adverse effects can be increased when Sertindole is combined with Dantrolene.
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Sertindole.
DapoxetineThe risk or severity of adverse effects can be increased when Sertindole is combined with Dapoxetine.
DarifenacinThe metabolism of Sertindole can be decreased when combined with Darifenacin.
DarunavirThe serum concentration of Sertindole can be increased when it is combined with Darunavir.
DasatinibThe serum concentration of Sertindole can be increased when it is combined with Dasatinib.
DeferasiroxThe serum concentration of Sertindole can be decreased when it is combined with Deferasirox.
DelavirdineThe metabolism of Sertindole can be decreased when combined with Delavirdine.
deramciclaneThe risk or severity of adverse effects can be increased when Sertindole is combined with deramciclane.
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Sertindole.
DesipramineThe risk or severity of adverse effects can be increased when Desipramine is combined with Sertindole.
DesloratadineThe risk or severity of adverse effects can be increased when Sertindole is combined with Desloratadine.
DesvenlafaxineThe risk or severity of adverse effects can be increased when Desvenlafaxine is combined with Sertindole.
DetomidineThe risk or severity of adverse effects can be increased when Sertindole is combined with Detomidine.
DexamethasoneThe serum concentration of Sertindole can be decreased when it is combined with Dexamethasone.
DexbrompheniramineThe risk or severity of adverse effects can be increased when Sertindole is combined with Dexbrompheniramine.
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Sertindole.
DextroamphetamineSertindole may decrease the stimulatory activities of Dextroamphetamine.
DextromethorphanThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Sertindole.
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Sertindole.
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Sertindole.
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Sertindole.
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Sertindole.
DifenoxinThe risk or severity of adverse effects can be increased when Sertindole is combined with Difenoxin.
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Sertindole.
DihydroergotamineThe risk or severity of adverse effects can be increased when Dihydroergotamine is combined with Sertindole.
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Sertindole.
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Sertindole.
DiltiazemThe metabolism of Sertindole can be decreased when combined with Diltiazem.
DimenhydrinateThe risk or severity of adverse effects can be increased when Sertindole is combined with Dimenhydrinate.
DiphenhydramineThe metabolism of Sertindole can be decreased when combined with Diphenhydramine.
DiphenhydramineThe risk or severity of adverse effects can be increased when Sertindole is combined with Diphenhydramine.
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Sertindole.
DoramectinThe risk or severity of adverse effects can be increased when Sertindole is combined with Doramectin.
DoxepinThe risk or severity of adverse effects can be increased when Doxepin is combined with Sertindole.
DoxycyclineThe metabolism of Sertindole can be decreased when combined with Doxycycline.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Sertindole.
DoxylamineThe risk or severity of adverse effects can be increased when Sertindole is combined with Doxylamine.
DPDPEThe risk or severity of adverse effects can be increased when Sertindole is combined with DPDPE.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Sertindole.
DronedaroneThe metabolism of Sertindole can be decreased when combined with Dronedarone.
DroperidolThe risk or severity of adverse effects can be increased when Droperidol is combined with Sertindole.
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Sertindole.
DuloxetineThe risk or severity of adverse effects can be increased when Duloxetine is combined with Sertindole.
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Sertindole.
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Sertindole.
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when ECGONINE METHYL ESTER is combined with Sertindole.
EfavirenzThe serum concentration of Sertindole can be decreased when it is combined with Efavirenz.
EfavirenzThe risk or severity of adverse effects can be increased when Sertindole is combined with Efavirenz.
EletriptanThe risk or severity of adverse effects can be increased when Eletriptan is combined with Sertindole.
EliglustatThe metabolism of Sertindole can be decreased when combined with Eliglustat.
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Sertindole.
EntacaponeThe risk or severity of adverse effects can be increased when Sertindole is combined with Entacapone.
EnzalutamideThe serum concentration of Sertindole can be decreased when it is combined with Enzalutamide.
Ergoloid mesylateThe risk or severity of adverse effects can be increased when Ergoloid mesylate is combined with Sertindole.
ErgonovineThe risk or severity of adverse effects can be increased when Ergonovine is combined with Sertindole.
ErgotamineThe risk or severity of adverse effects can be increased when Ergotamine is combined with Sertindole.
ErythromycinThe metabolism of Sertindole can be decreased when combined with Erythromycin.
EscitalopramThe risk or severity of adverse effects can be increased when Sertindole is combined with Escitalopram.
Eslicarbazepine acetateThe serum concentration of Sertindole can be decreased when it is combined with Eslicarbazepine acetate.
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Sertindole.
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Sertindole.
EthanolSertindole may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Sertindole.
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Sertindole.
EthosuximideThe risk or severity of adverse effects can be increased when Sertindole is combined with Ethosuximide.
EthotoinThe risk or severity of adverse effects can be increased when Sertindole is combined with Ethotoin.
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Sertindole.
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Sertindole.
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Sertindole.
EtidocaineThe risk or severity of adverse effects can be increased when Sertindole is combined with Etidocaine.
EtifoxineThe risk or severity of adverse effects can be increased when Sertindole is combined with Etifoxine.
EtizolamThe risk or severity of adverse effects can be increased when Sertindole is combined with Etizolam.
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Sertindole.
EtoperidoneThe risk or severity of adverse effects can be increased when Sertindole is combined with Etoperidone.
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Sertindole.
EtravirineThe serum concentration of Sertindole can be decreased when it is combined with Etravirine.
EzogabineThe risk or severity of adverse effects can be increased when Sertindole is combined with Ezogabine.
FelbamateThe risk or severity of adverse effects can be increased when Sertindole is combined with Felbamate.
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Sertindole.
FenfluramineThe risk or severity of adverse effects can be increased when Sertindole is combined with Fenfluramine.
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Sertindole.
FexofenadineThe risk or severity of adverse effects can be increased when Sertindole is combined with Fexofenadine.
FlibanserinThe risk or severity of adverse effects can be increased when Sertindole is combined with Flibanserin.
FluconazoleThe metabolism of Sertindole can be decreased when combined with Fluconazole.
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Sertindole.
FlunarizineThe risk or severity of adverse effects can be increased when Sertindole is combined with Flunarizine.
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Sertindole.
FluoxetineThe risk or severity of adverse effects can be increased when Sertindole is combined with Fluoxetine.
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Sertindole.
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Sertindole.
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Sertindole.
FluspirileneThe risk or severity of adverse effects can be increased when Fluspirilene is combined with Sertindole.
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Sertindole is combined with Fluticasone Propionate.
FluvoxamineThe risk or severity of adverse effects can be increased when Sertindole is combined with Fluvoxamine.
FosamprenavirThe metabolism of Sertindole can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Sertindole can be increased when it is combined with Fosaprepitant.
FosphenytoinThe risk or severity of adverse effects can be increased when Sertindole is combined with Fosphenytoin.
FospropofolThe risk or severity of adverse effects can be increased when Sertindole is combined with Fospropofol.
FrovatriptanThe risk or severity of adverse effects can be increased when Frovatriptan is combined with Sertindole.
Fusidic AcidThe serum concentration of Sertindole can be increased when it is combined with Fusidic Acid.
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Sertindole.
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Sertindole is combined with gabapentin enacarbil.
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Sertindole.
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Sertindole.
GuanfacineThe risk or severity of adverse effects can be increased when Sertindole is combined with Guanfacine.
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Sertindole.
HaloperidolThe metabolism of Sertindole can be decreased when combined with Haloperidol.
HaloperidolThe risk or severity of adverse effects can be increased when Sertindole is combined with Haloperidol.
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Sertindole.
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Sertindole.
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Sertindole.
HydrocodoneThe risk or severity of adverse effects can be increased when Hydrocodone is combined with Sertindole.
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Sertindole.
Hydroxyamphetamine hydrobromideSertindole may decrease the stimulatory activities of Hydroxyamphetamine hydrobromide.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Sertindole.
HydroxyzineThe risk or severity of adverse effects can be increased when Sertindole is combined with Hydroxyzine.
IdelalisibThe serum concentration of Sertindole can be increased when it is combined with Idelalisib.
IloperidoneThe risk or severity of adverse effects can be increased when Sertindole is combined with Iloperidone.
ImatinibThe metabolism of Sertindole can be decreased when combined with Imatinib.
ImipramineThe risk or severity of adverse effects can be increased when Imipramine is combined with Sertindole.
IndalpineThe risk or severity of adverse effects can be increased when Sertindole is combined with Indalpine.
IndinavirThe metabolism of Sertindole can be decreased when combined with Indinavir.
IsavuconazoniumThe metabolism of Sertindole can be decreased when combined with Isavuconazonium.
IsocarboxazidThe risk or severity of adverse effects can be increased when Isocarboxazid is combined with Sertindole.
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Sertindole.
IsoniazidThe metabolism of Sertindole can be decreased when combined with Isoniazid.
IsradipineThe metabolism of Sertindole can be decreased when combined with Isradipine.
ItraconazoleThe metabolism of Sertindole can be decreased when combined with Itraconazole.
IvacaftorThe serum concentration of Sertindole can be increased when it is combined with Ivacaftor.
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Sertindole.
KetazolamThe risk or severity of adverse effects can be increased when Ketazolam is combined with Sertindole.
KetobemidoneThe risk or severity of adverse effects can be increased when Sertindole is combined with Ketobemidone.
KetoconazoleThe metabolism of Sertindole can be decreased when combined with Ketoconazole.
LamotrigineThe risk or severity of adverse effects can be increased when Sertindole is combined with Lamotrigine.
LevetiracetamThe risk or severity of adverse effects can be increased when Sertindole is combined with Levetiracetam.
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Sertindole.
LevocabastineThe risk or severity of adverse effects can be increased when Sertindole is combined with Levocabastine.
LevocetirizineThe risk or severity of adverse effects can be increased when Sertindole is combined with Levocetirizine.
LevodopaThe risk or severity of adverse effects can be increased when Sertindole is combined with Levodopa.
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Sertindole.
LevomilnacipranThe risk or severity of adverse effects can be increased when Sertindole is combined with Levomilnacipran.
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Sertindole.
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Sertindole.
LinezolidThe risk or severity of adverse effects can be increased when Linezolid is combined with Sertindole.
LisdexamfetamineSertindole may decrease the stimulatory activities of Lisdexamfetamine.
LithiumLithium may increase the neurotoxic activities of Sertindole.
LithiumThe risk or severity of adverse effects can be increased when Sertindole is combined with Lithium.
LofentanilThe risk or severity of adverse effects can be increased when Sertindole is combined with Lofentanil.
LopinavirThe metabolism of Sertindole can be decreased when combined with Lopinavir.
LoratadineThe risk or severity of adverse effects can be increased when Sertindole is combined with Loratadine.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Sertindole.
LorcaserinThe risk or severity of adverse effects can be increased when Lorcaserin is combined with Sertindole.
LovastatinThe metabolism of Sertindole can be decreased when combined with Lovastatin.
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Sertindole.
Lu AA21004The risk or severity of adverse effects can be increased when Sertindole is combined with Lu AA21004.
LuliconazoleThe serum concentration of Sertindole can be increased when it is combined with Luliconazole.
LumefantrineThe metabolism of Sertindole can be decreased when combined with Lumefantrine.
LurasidoneThe risk or severity of adverse effects can be increased when Sertindole is combined with Lurasidone.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Sertindole.
Magnesium SulfateThe risk or severity of adverse effects can be increased when Sertindole is combined with Magnesium Sulfate.
MaprotilineThe risk or severity of adverse effects can be increased when Maprotiline is combined with Sertindole.
MeclizineThe risk or severity of adverse effects can be increased when Sertindole is combined with Meclizine.
MedetomidineThe risk or severity of adverse effects can be increased when Sertindole is combined with Medetomidine.
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Sertindole.
MelperoneThe risk or severity of adverse effects can be increased when Sertindole is combined with Melperone.
MephentermineSertindole may decrease the stimulatory activities of Mephentermine.
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Sertindole.
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Sertindole.
MequitazineSertindole may increase the arrhythmogenic activities of Mequitazine.
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Sertindole.
MetaxaloneThe risk or severity of adverse effects can be increased when Sertindole is combined with Metaxalone.
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Sertindole.
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Sertindole.
MethamphetamineSertindole may decrease the stimulatory activities of Methamphetamine.
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Sertindole.
MethaqualoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Sertindole.
MethocarbamolThe risk or severity of adverse effects can be increased when Sertindole is combined with Methocarbamol.
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Sertindole.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Methotrimeprazine is combined with Sertindole.
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Sertindole.
MethsuximideThe risk or severity of adverse effects can be increased when Sertindole is combined with Methsuximide.
MethylphenidateThe risk or severity of adverse effects can be increased when Sertindole is combined with Methylphenidate.
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Sertindole.
MetoclopramideThe risk or severity of adverse effects can be increased when Metoclopramide is combined with Sertindole.
MetoprololThe metabolism of Sertindole can be decreased when combined with Metoprolol.
MetyrosineSertindole may increase the sedative activities of Metyrosine.
MetyrosineThe risk or severity of adverse effects can be increased when Metyrosine is combined with Sertindole.
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Sertindole.
MifepristoneThe metabolism of Sertindole can be decreased when combined with Mifepristone.
MilnacipranThe risk or severity of adverse effects can be increased when Sertindole is combined with Milnacipran.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Sertindole.
MirabegronThe metabolism of Sertindole can be decreased when combined with Mirabegron.
MirtazapineSertindole may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MirtazapineThe risk or severity of adverse effects can be increased when Mirtazapine is combined with Sertindole.
MitotaneThe serum concentration of Sertindole can be decreased when it is combined with Mitotane.
MoclobemideThe risk or severity of adverse effects can be increased when Moclobemide is combined with Sertindole.
ModafinilThe serum concentration of Sertindole can be decreased when it is combined with Modafinil.
MolindoneThe risk or severity of adverse effects can be increased when Molindone is combined with Sertindole.
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Sertindole.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Sertindole.
NabiloneThe risk or severity of adverse effects can be increased when Sertindole is combined with Nabilone.
NafcillinThe serum concentration of Sertindole can be decreased when it is combined with Nafcillin.
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Sertindole.
NaratriptanThe risk or severity of adverse effects can be increased when Naratriptan is combined with Sertindole.
NefazodoneThe risk or severity of adverse effects can be increased when Nefazodone is combined with Sertindole.
NelfinavirThe metabolism of Sertindole can be decreased when combined with Nelfinavir.
NetupitantThe serum concentration of Sertindole can be increased when it is combined with Netupitant.
NevirapineThe metabolism of Sertindole can be decreased when combined with Nevirapine.
NicardipineThe metabolism of Sertindole can be decreased when combined with Nicardipine.
NilotinibThe metabolism of Sertindole can be decreased when combined with Nilotinib.
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Sertindole.
Nitrous oxideThe risk or severity of adverse effects can be increased when Sertindole is combined with Nitrous oxide.
NormethadoneThe risk or severity of adverse effects can be increased when Sertindole is combined with Normethadone.
NortriptylineThe risk or severity of adverse effects can be increased when Nortriptyline is combined with Sertindole.
OlanzapineThe risk or severity of adverse effects can be increased when Sertindole is combined with Olanzapine.
OlaparibThe metabolism of Sertindole can be decreased when combined with Olaparib.
OlopatadineThe risk or severity of adverse effects can be increased when Sertindole is combined with Olopatadine.
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Sertindole.
OpiumThe risk or severity of adverse effects can be increased when Sertindole is combined with Opium.
OrphenadrineSertindole may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OrphenadrineThe risk or severity of adverse effects can be increased when Orphenadrine is combined with Sertindole.
OsanetantThe risk or severity of adverse effects can be increased when Osanetant is combined with Sertindole.
OsimertinibThe serum concentration of Sertindole can be increased when it is combined with Osimertinib.
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Sertindole.
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Sertindole.
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Sertindole.
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Sertindole.
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Sertindole.
PalbociclibThe serum concentration of Sertindole can be increased when it is combined with Palbociclib.
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Sertindole.
PanobinostatThe metabolism of Sertindole can be decreased when combined with Panobinostat.
ParaldehydeSertindole may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParaldehydeThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Sertindole.
ParoxetineThe risk or severity of adverse effects can be increased when Sertindole is combined with Paroxetine.
Peginterferon alfa-2bThe serum concentration of Sertindole can be decreased when it is combined with Peginterferon alfa-2b.
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Sertindole.
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Sertindole.
PerampanelThe risk or severity of adverse effects can be increased when Sertindole is combined with Perampanel.
PerospironeThe risk or severity of adverse effects can be increased when Sertindole is combined with Perospirone.
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Sertindole.
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Sertindole.
PhenelzineThe risk or severity of adverse effects can be increased when Phenelzine is combined with Sertindole.
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Sertindole.
PhenoxyethanolThe risk or severity of adverse effects can be increased when Sertindole is combined with Phenoxyethanol.
PhentermineSertindole may decrease the stimulatory activities of Phentermine.
PhenytoinThe risk or severity of adverse effects can be increased when Sertindole is combined with Phenytoin.
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Sertindole.
PipamperoneThe risk or severity of adverse effects can be increased when Sertindole is combined with Pipamperone.
PipotiazineThe risk or severity of adverse effects can be increased when Sertindole is combined with Pipotiazine.
PizotifenThe risk or severity of adverse effects can be increased when Sertindole is combined with Pizotifen.
PomalidomideThe risk or severity of adverse effects can be increased when Sertindole is combined with Pomalidomide.
PosaconazoleThe metabolism of Sertindole can be decreased when combined with Posaconazole.
PramipexoleSertindole may increase the sedative activities of Pramipexole.
PramocaineThe risk or severity of adverse effects can be increased when Sertindole is combined with Pramocaine.
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with Sertindole.
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Sertindole.
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Sertindole.
PrimidoneThe risk or severity of adverse effects can be increased when Sertindole is combined with Primidone.
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Sertindole.
ProcarbazineThe risk or severity of adverse effects can be increased when Procarbazine is combined with Sertindole.
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Sertindole.
PromazineThe metabolism of Sertindole can be decreased when combined with Promazine.
PromazineThe risk or severity of adverse effects can be increased when Sertindole is combined with Promazine.
PromethazineThe risk or severity of adverse effects can be increased when Promethazine is combined with Sertindole.
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Sertindole.
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Sertindole.
PropoxycaineThe risk or severity of adverse effects can be increased when Sertindole is combined with Propoxycaine.
ProtriptylineThe risk or severity of adverse effects can be increased when Protriptyline is combined with Sertindole.
PSD502The risk or severity of adverse effects can be increased when Sertindole is combined with PSD502.
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Sertindole.
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Sertindole.
QuinagolideThe therapeutic efficacy of Quinagolide can be decreased when used in combination with Sertindole.
QuinidineThe metabolism of Sertindole can be decreased when combined with Quinidine.
QuinineThe metabolism of Sertindole can be decreased when combined with Quinine.
RamelteonThe risk or severity of adverse effects can be increased when Sertindole is combined with Ramelteon.
RanolazineThe metabolism of Sertindole can be decreased when combined with Ranolazine.
RasagilineThe risk or severity of adverse effects can be increased when Rasagiline is combined with Sertindole.
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Sertindole.
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Sertindole.
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Sertindole.
RifabutinThe metabolism of Sertindole can be increased when combined with Rifabutin.
RifampicinThe metabolism of Sertindole can be increased when combined with Rifampicin.
RifapentineThe metabolism of Sertindole can be increased when combined with Rifapentine.
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Sertindole.
RitonavirThe metabolism of Sertindole can be decreased when combined with Ritonavir.
RizatriptanThe risk or severity of adverse effects can be increased when Rizatriptan is combined with Sertindole.
RolapitantThe metabolism of Sertindole can be decreased when combined with Rolapitant.
RomifidineThe risk or severity of adverse effects can be increased when Sertindole is combined with Romifidine.
RopiniroleSertindole may increase the sedative activities of Ropinirole.
RopiniroleThe metabolism of Sertindole can be decreased when combined with Ropinirole.
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Sertindole.
RotigotineSertindole may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Sertindole.
S-EthylisothioureaThe risk or severity of adverse effects can be increased when S-Ethylisothiourea is combined with Sertindole.
SaquinavirThe metabolism of Sertindole can be decreased when combined with Saquinavir.
ScopolamineThe risk or severity of adverse effects can be increased when Sertindole is combined with Scopolamine.
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Sertindole.
SelegilineThe risk or severity of adverse effects can be increased when Selegiline is combined with Sertindole.
SertralineThe risk or severity of adverse effects can be increased when Sertindole is combined with Sertraline.
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Sertindole.
SildenafilThe metabolism of Sertindole can be decreased when combined with Sildenafil.
SiltuximabThe serum concentration of Sertindole can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Sertindole can be increased when it is combined with Simeprevir.
Sodium oxybateThe risk or severity of adverse effects can be increased when Sertindole is combined with Sodium oxybate.
St. John's WortThe serum concentration of Sertindole can be decreased when it is combined with St. John's Wort.
StiripentolThe risk or severity of adverse effects can be increased when Sertindole is combined with Stiripentol.
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Sertindole.
SulfisoxazoleThe metabolism of Sertindole can be decreased when combined with Sulfisoxazole.
SulpirideThe risk or severity of adverse effects can be increased when Sertindole is combined with Sulpiride.
SumatriptanThe risk or severity of adverse effects can be increased when Sumatriptan is combined with Sertindole.
SuvorexantThe risk or severity of adverse effects can be increased when Sertindole is combined with Suvorexant.
TapentadolThe risk or severity of adverse effects can be increased when Tapentadol is combined with Sertindole.
TasimelteonThe risk or severity of adverse effects can be increased when Sertindole is combined with Tasimelteon.
Tedizolid PhosphateThe risk or severity of adverse effects can be increased when Tedizolid Phosphate is combined with Sertindole.
TelaprevirThe metabolism of Sertindole can be decreased when combined with Telaprevir.
TelithromycinThe metabolism of Sertindole can be decreased when combined with Telithromycin.
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Sertindole.
TerbinafineThe metabolism of Sertindole can be decreased when combined with Terbinafine.
TetrabenazineThe risk or severity of adverse effects can be increased when Tetrabenazine is combined with Sertindole.
TetracaineThe risk or severity of adverse effects can be increased when Sertindole is combined with Tetracaine.
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Sertindole.
ThalidomideSertindole may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Sertindole.
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Sertindole.
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Sertindole.
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Sertindole.
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Sertindole.
TiagabineThe risk or severity of adverse effects can be increased when Sertindole is combined with Tiagabine.
TiclopidineThe metabolism of Sertindole can be decreased when combined with Ticlopidine.
TiletamineThe risk or severity of adverse effects can be increased when Sertindole is combined with Tiletamine.
TipranavirThe metabolism of Sertindole can be decreased when combined with Tipranavir.
TizanidineThe risk or severity of adverse effects can be increased when Sertindole is combined with Tizanidine.
TocilizumabThe serum concentration of Sertindole can be decreased when it is combined with Tocilizumab.
TolcaponeThe risk or severity of adverse effects can be increased when Sertindole is combined with Tolcapone.
TopiramateThe risk or severity of adverse effects can be increased when Sertindole is combined with Topiramate.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Sertindole.
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with Sertindole.
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Sertindole.
TrazodoneThe risk or severity of adverse effects can be increased when Sertindole is combined with Trazodone.
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Sertindole.
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Sertindole.
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Sertindole.
TrimipramineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Sertindole.
TriprolidineThe risk or severity of adverse effects can be increased when Sertindole is combined with Triprolidine.
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Sertindole.
VenlafaxineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Sertindole.
VerapamilThe metabolism of Sertindole can be decreased when combined with Verapamil.
VigabatrinThe risk or severity of adverse effects can be increased when Sertindole is combined with Vigabatrin.
VilazodoneThe risk or severity of adverse effects can be increased when Sertindole is combined with Vilazodone.
VoriconazoleThe metabolism of Sertindole can be decreased when combined with Voriconazole.
VortioxetineThe risk or severity of adverse effects can be increased when Sertindole is combined with Vortioxetine.
XylazineThe risk or severity of adverse effects can be increased when Sertindole is combined with Xylazine.
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Sertindole.
ZiconotideThe risk or severity of adverse effects can be increased when Sertindole is combined with Ziconotide.
ZimelidineThe risk or severity of adverse effects can be increased when Sertindole is combined with Zimelidine.
ZiprasidoneThe metabolism of Sertindole can be decreased when combined with Ziprasidone.
ZiprasidoneThe risk or severity of adverse effects can be increased when Sertindole is combined with Ziprasidone.
ZolazepamThe risk or severity of adverse effects can be increased when Sertindole is combined with Zolazepam.
ZolmitriptanThe risk or severity of adverse effects can be increased when Zolmitriptan is combined with Sertindole.
ZolpidemThe risk or severity of adverse effects can be increased when Zolpidem is combined with Sertindole.
ZonisamideThe risk or severity of adverse effects can be increased when Sertindole is combined with Zonisamide.
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Sertindole.
ZotepineThe risk or severity of adverse effects can be increased when Sertindole is combined with Zotepine.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Sertindole.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Potassium channel regulator activity
Specific Function:
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.
Gene Name:
DRD2
Uniprot ID:
P14416
Molecular Weight:
50618.91 Da
References
  1. Lindstrom E, Levander S: Sertindole: efficacy and safety in schizophrenia. Expert Opin Pharmacother. 2006 Sep;7(13):1825-34. [PubMed:16925508 ]
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  3. Mork A, Witten LM, Arnt J: Effect of sertindole on extracellular dopamine, acetylcholine, and glutamate in the medial prefrontal cortex of conscious rats: a comparison with risperidone and exploration of mechanisms involved. Psychopharmacology (Berl). 2009 Sep;206(1):39-49. doi: 10.1007/s00213-009-1578-4. Epub 2009 Jun 9. [PubMed:19506838 ]
  4. Seeman P: Dopamine D2(High) receptors moderately elevated by sertindole. Synapse. 2008 May;62(5):389-93. doi: 10.1002/syn.20498. [PubMed:18293356 ]
  5. Cincotta SL, Rodefer JS: Emerging role of sertindole in the management of schizophrenia. Neuropsychiatr Dis Treat. 2010 Sep 7;6:429-41. [PubMed:20856607 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Virus receptor activity
Specific Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates...
Gene Name:
HTR2A
Uniprot ID:
P28223
Molecular Weight:
52602.58 Da
References
  1. Lindstrom E, Levander S: Sertindole: efficacy and safety in schizophrenia. Expert Opin Pharmacother. 2006 Sep;7(13):1825-34. [PubMed:16925508 ]
  2. Schreiber R, Brocco M, Millan MJ: Blockade of the discriminative stimulus effects of DOI by MDL 100,907 and the 'atypical' antipsychotics, clozapine and risperidone. Eur J Pharmacol. 1994 Oct 13;264(1):99-102. [PubMed:7530204 ]
  3. Hietala J, Kuonnamaki M, Palvimaki EP, Laakso A, Majasuo H, Syvalahti E: Sertindole is a serotonin 5-HT2c inverse agonist and decreases agonist but not antagonist binding to 5-HT2c receptors after chronic treatment. Psychopharmacology (Berl). 2001 Sep;157(2):180-7. [PubMed:11594443 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Serotonin receptor activity
Specific Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modul...
Gene Name:
HTR2C
Uniprot ID:
P28335
Molecular Weight:
51820.705 Da
References
  1. Lindstrom E, Levander S: Sertindole: efficacy and safety in schizophrenia. Expert Opin Pharmacother. 2006 Sep;7(13):1825-34. [PubMed:16925508 ]
  2. Hietala J, Kuonnamaki M, Palvimaki EP, Laakso A, Majasuo H, Syvalahti E: Sertindole is a serotonin 5-HT2c inverse agonist and decreases agonist but not antagonist binding to 5-HT2c receptors after chronic treatment. Psychopharmacology (Berl). 2001 Sep;157(2):180-7. [PubMed:11594443 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Serotonin receptor activity
Specific Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through...
Gene Name:
HTR6
Uniprot ID:
P50406
Molecular Weight:
46953.625 Da
References
  1. Pouzet B, Didriksen M, Arnt J: Effects of the 5-HT(6) receptor antagonist, SB-271046, in animal models for schizophrenia. Pharmacol Biochem Behav. 2002 Apr;71(4):635-43. [PubMed:11888555 ]
  2. Mork A, Witten LM, Arnt J: Effect of sertindole on extracellular dopamine, acetylcholine, and glutamate in the medial prefrontal cortex of conscious rats: a comparison with risperidone and exploration of mechanisms involved. Psychopharmacology (Berl). 2009 Sep;206(1):39-49. doi: 10.1007/s00213-009-1578-4. Epub 2009 Jun 9. [PubMed:19506838 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
Specific Function:
Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoforms USO have no channel activity by themself, but modulates channel characteristics by forming heterotetramers with other isoforms which are r...
Gene Name:
KCNH2
Uniprot ID:
Q12809
Molecular Weight:
126653.52 Da
References
  1. Rampe D, Murawsky MK, Grau J, Lewis EW: The antipsychotic agent sertindole is a high affinity antagonist of the human cardiac potassium channel HERG. J Pharmacol Exp Ther. 1998 Aug;286(2):788-93. [PubMed:9694935 ]
  2. Kang J, Chen XL, Rampe D: The antipsychotic drugs sertindole and pimozide block erg3, a human brain K(+) channel. Biochem Biophys Res Commun. 2001 Aug 24;286(3):499-504. [PubMed:11511086 ]
  3. Tang W, Kang J, Wu X, Rampe D, Wang L, Shen H, Li Z, Dunnington D, Garyantes T: Development and evaluation of high throughput functional assay methods for HERG potassium channel. J Biomol Screen. 2001 Oct;6(5):325-31. [PubMed:11689132 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Protein heterodimerization activity
Specific Function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
Gene Name:
ADRA1A
Uniprot ID:
P35348
Molecular Weight:
51486.005 Da
References
  1. Lindstrom E, Levander S: Sertindole: efficacy and safety in schizophrenia. Expert Opin Pharmacother. 2006 Sep;7(13):1825-34. [PubMed:16925508 ]
  2. Hietala J, Kuonnamaki M, Palvimaki EP, Laakso A, Majasuo H, Syvalahti E: Sertindole is a serotonin 5-HT2c inverse agonist and decreases agonist but not antagonist binding to 5-HT2c receptors after chronic treatment. Psychopharmacology (Berl). 2001 Sep;157(2):180-7. [PubMed:11594443 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Protein heterodimerization activity
Specific Function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
Gene Name:
ADRA1B
Uniprot ID:
P35368
Molecular Weight:
56835.375 Da
References
  1. Lindstrom E, Levander S: Sertindole: efficacy and safety in schizophrenia. Expert Opin Pharmacother. 2006 Sep;7(13):1825-34. [PubMed:16925508 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Alpha1-adrenergic receptor activity
Specific Function:
This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.
Gene Name:
ADRA1D
Uniprot ID:
P25100
Molecular Weight:
60462.205 Da
References
  1. Lindstrom E, Levander S: Sertindole: efficacy and safety in schizophrenia. Expert Opin Pharmacother. 2006 Sep;7(13):1825-34. [PubMed:16925508 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
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Drug created on November 19, 2007 09:49 / Updated on August 17, 2016 12:24