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Identification
NameSimeprevir
Accession NumberDB06290
TypeSmall Molecule
GroupsApproved
DescriptionSimeprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor indicated in patient's with HCV genotype 1 for the treatment of chronic hepatitis as a combination therapy, which includes peginterferon alfa and ribavirin. It was approved by the FDA in November 2014 and is marketed under the brand name Olysio.
Structure
Thumb
SynonymsNot Available
External Identifiers
  • TMC 435
  • TMC 435350
  • TMC-435
  • TMC-435350
  • TMC435
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Galexoscapsule150 mgoralJanssen Inc2013-11-25Not applicableCanada
Olysiocapsule150 mg/1oralJanssen Products LP2013-11-22Not applicableUs
OlysioCapsule, hard150 mgOral useJanssen Cilag International N.V.2014-05-14Not applicableEu
OlysioCapsule, hard150 mgOral useJanssen Cilag International N.V.2014-05-14Not applicableEu
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Simeprevir sodium
ThumbNot applicableDBSALT001485
Categories
UNII9WS5RD66HZ
CAS number923604-59-5
WeightAverage: 749.939
Monoisotopic: 749.291690263
Chemical FormulaC38H47N5O7S2
InChI KeyJTZZSQYMACOLNN-VDWJNHBNSA-N
InChI
InChI=1S/C38H47N5O7S2/c1-21(2)30-20-51-35(40-30)29-18-32(26-13-14-31(49-5)22(3)33(26)39-29)50-24-16-27-28(17-24)36(45)43(4)15-9-7-6-8-10-23-19-38(23,41-34(27)44)37(46)42-52(47,48)25-11-12-25/h8,10,13-14,18,20-21,23-25,27-28H,6-7,9,11-12,15-17,19H2,1-5H3,(H,41,44)(H,42,46)/b10-8-/t23-,24-,27-,28-,38-/m1/s1
IUPAC Name
(1R,4R,6S,7Z,15R,17R)-N-(cyclopropanesulfonyl)-2-hydroxy-17-({7-methoxy-8-methyl-2-[4-(propan-2-yl)-1,3-thiazol-2-yl]quinolin-4-yl}oxy)-13-methyl-14-oxo-3,13-diazatricyclo[13.3.0.0⁴,⁶]octadeca-2,7-diene-4-carboximidic acid
SMILES
[H]\C1=C([H])\[C@]2([H])C[C@]2(N=C(O)[C@]2([H])C[C@]([H])(C[C@@]2([H])C(=O)N(C)CCCC1)OC1=C2C=CC(OC)=C(C)C2=NC(=C1)C1=NC(=CS1)C(C)C)C(O)=NS(=O)(=O)C1CC1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as macrolactams. These are cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. They are nitrogen analogues (the a nitrogen atom replacing the o atom of the cyclic carboxylic acid group ) of the naturally occurring macrolides.
KingdomOrganic compounds
Super ClassPhenylpropanoids and polyketides
ClassMacrolactams
Sub ClassNot Available
Direct ParentMacrolactams
Alternative Parents
Substituents
  • Macrolactam
  • Alpha-amino acid amide
  • Quinoline
  • Anisole
  • Alkyl aryl ether
  • 2,4-disubstituted 1,3-thiazole
  • Benzenoid
  • Pyridine
  • Cyclopropanecarboxylic acid or derivatives
  • Heteroaromatic compound
  • Aminosulfonyl compound
  • Thiazole
  • Tertiary carboxylic acid amide
  • Sulfonyl
  • Sulfonic acid derivative
  • Sulfonamide
  • Azole
  • Tertiary amine
  • Secondary carboxylic acid amide
  • Lactam
  • Carboxamide group
  • Azacycle
  • Organoheterocyclic compound
  • Ether
  • Carboxylic acid derivative
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Organosulfur compound
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationSimeprevir is indicated in patient's with hepatitis C virus (HCV) genotype 1 for the treatment of chronic hepatitis as a combination therapy, which includes peginterferon alfa and ribavirin.
PharmacodynamicsSimeprevir is a protease inhibitor for HCV NS3/4A protease, which is required for replication of the virus.
Mechanism of actionSimeprevir functions as a direct-acting antiviral agent because it inhibits hepatitis C viral replication by binding to and inhibiting the protease, hepatitis C virus (HCV) NS3/4A.
Related Articles
AbsorptionAfter oral administration, simeprevir reaches its maximum plasma concentrations in 4-6 hours.
Volume of distribution

The volume of distribution for simeprevir has yet to be determined.

Protein bindingSimeprevir is >99.9% plasma protein bound with albumin being the main plasma protein.
Metabolism

Simeprevir is mainly metabolized by CYP3A enzymes.

Route of eliminationSimeprevir is mainly eliminated through biliary excretion (91%). Elimination through the urine is insignificant (1%).
Half lifeThe half-life of simeprevir is about 41 hours in HCV patients.
Clearance

The clearance of simeprevir has yet to be determined.

ToxicityIn patients receiving the combination therapy, the most common adverse reactions were nausea, pruritus, photosensitivity, and rash.
Affected organisms
  • Hepatitis C virus, RSV and other RNA/DNA viruses
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal AbsorptionNot AvailableNot Available
Blood Brain BarrierNot AvailableNot Available
Caco-2 permeableNot AvailableNot Available
P-glycoprotein substrateNot AvailableNot Available
P-glycoprotein inhibitor INot AvailableNot Available
P-glycoprotein inhibitor IINot AvailableNot Available
Renal organic cation transporterNot AvailableNot Available
CYP450 2C9 substrateNot AvailableNot Available
CYP450 2D6 substrateNot AvailableNot Available
CYP450 3A4 substrateNot AvailableNot Available
CYP450 1A2 substrateNot AvailableNot Available
CYP450 2C9 inhibitorNot AvailableNot Available
CYP450 2D6 inhibitorNot AvailableNot Available
CYP450 2C19 inhibitorNot AvailableNot Available
CYP450 3A4 inhibitorNot AvailableNot Available
CYP450 inhibitory promiscuityNot AvailableNot Available
Ames testNot AvailableNot Available
CarcinogenicityNot AvailableNot Available
BiodegradationNot AvailableNot Available
Rat acute toxicityNot AvailableNot applicable
hERG inhibition (predictor I)Not AvailableNot Available
hERG inhibition (predictor II)Not AvailableNot Available
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
Capsuleoral150 mg
Capsuleoral150 mg/1
Capsule, hardOral use150 mg
PricesNot Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US7671032 No2005-05-192025-05-19Us
US8148399 No2009-09-052029-09-05Us
US8349869 No2006-07-282026-07-28Us
US8741926 No2006-07-282026-07-28Us
US8754106 No2006-07-282026-07-28Us
US9040562 No2006-07-282026-07-28Us
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.00458 mg/mLALOGPS
logP4.82ALOGPS
logP5.74ChemAxon
logS-5.2ALOGPS
pKa (Strongest Acidic)5.87ChemAxon
pKa (Strongest Basic)1.7ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count11ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area163.87 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity207.79 m3·mol-1ChemAxon
Polarizability80.18 Å3ChemAxon
Number of Rings7ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

Raboisson P, de Kock H, Rosenquist A, Nilsson M, Salvador-Oden L, Lin TI, Roue N, Ivanov V, Wahling H, Wickstrom K, Hamelink E, Edlund M, Vrang L, Vendeville S, Van de Vreken W, McGowan D, Tahri A, Hu L, Boutton C, Lenz O, Delouvroy F, Pille G, Surleraux D, Wigerinck P, Samuelsson B, Simmen K: Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4853-8. doi: 10.1016/j.bmcl.2008.07.088. Epub 2008 Jul 24.

General References
  1. Raboisson P, de Kock H, Rosenquist A, Nilsson M, Salvador-Oden L, Lin TI, Roue N, Ivanov V, Wahling H, Wickstrom K, Hamelink E, Edlund M, Vrang L, Vendeville S, Van de Vreken W, McGowan D, Tahri A, Hu L, Boutton C, Lenz O, Delouvroy F, Pille G, Surleraux D, Wigerinck P, Samuelsson B, Simmen K: Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4853-8. doi: 10.1016/j.bmcl.2008.07.088. Epub 2008 Jul 24. [PubMed:18678486 ]
External Links
ATC CodesJ05AE14
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (85.3 KB)
Interactions
Drug Interactions
Drug
1,10-PhenanthrolineThe serum concentration of Simeprevir can be increased when it is combined with 1,10-Phenanthroline.
3,4-DichloroisocoumarinThe serum concentration of Simeprevir can be increased when it is combined with 3,4-Dichloroisocoumarin.
4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDEThe serum concentration of Simeprevir can be increased when it is combined with 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE.
AbacavirThe serum concentration of Abacavir can be decreased when it is combined with Simeprevir.
AbirateroneThe serum concentration of Abiraterone can be increased when it is combined with Simeprevir.
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Simeprevir.
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Simeprevir.
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Simeprevir.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Simeprevir.
AdinazolamThe serum concentration of Adinazolam can be increased when it is combined with Simeprevir.
AfatinibThe serum concentration of Simeprevir can be increased when it is combined with Afatinib.
AgomelatineThe serum concentration of Agomelatine can be increased when it is combined with Simeprevir.
AlbendazoleThe serum concentration of Albendazole can be increased when it is combined with Simeprevir.
AlclometasoneThe serum concentration of Alclometasone can be increased when it is combined with Simeprevir.
AldosteroneThe serum concentration of Simeprevir can be decreased when it is combined with Aldosterone.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Simeprevir.
AlectinibThe serum concentration of Simeprevir can be increased when it is combined with Alectinib.
AlfentanilThe serum concentration of Alfentanil can be increased when it is combined with Simeprevir.
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Simeprevir.
AliskirenThe serum concentration of Aliskiren can be increased when it is combined with Simeprevir.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Simeprevir.
AllylestrenolThe serum concentration of Allylestrenol can be increased when it is combined with Simeprevir.
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Simeprevir.
AlogliptinThe serum concentration of Alogliptin can be increased when it is combined with Simeprevir.
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Simeprevir.
Alpha-1-proteinase inhibitorThe serum concentration of Simeprevir can be increased when it is combined with Alpha-1-proteinase inhibitor.
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Simeprevir.
AmantadineThe serum concentration of Simeprevir can be increased when it is combined with Amantadine.
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Simeprevir.
AmbroxolThe serum concentration of Ambroxol can be increased when it is combined with Simeprevir.
AmineptineThe serum concentration of Amineptine can be increased when it is combined with Simeprevir.
Aminohippuric acidThe serum concentration of Simeprevir can be increased when it is combined with Aminohippuric acid.
AminophenazoneThe serum concentration of Aminophenazone can be increased when it is combined with Simeprevir.
AminophyllineThe serum concentration of Aminophylline can be increased when it is combined with Simeprevir.
AmiodaroneThe serum concentration of Amiodarone can be increased when it is combined with Simeprevir.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Simeprevir.
AmlodipineThe serum concentration of Amlodipine can be increased when it is combined with Simeprevir.
AmprenavirThe serum concentration of Amprenavir can be increased when it is combined with Simeprevir.
AmsacrineThe serum concentration of Simeprevir can be increased when it is combined with Amsacrine.
AnagrelideThe metabolism of Anagrelide can be decreased when combined with Simeprevir.
AntipyrineThe serum concentration of Antipyrine can be increased when it is combined with Simeprevir.
Antithrombin III humanThe serum concentration of Simeprevir can be increased when it is combined with Antithrombin III human.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Simeprevir.
ApremilastThe serum concentration of Apremilast can be increased when it is combined with Simeprevir.
AprepitantThe serum concentration of Aprepitant can be increased when it is combined with Simeprevir.
AprotininThe serum concentration of Simeprevir can be increased when it is combined with Aprotinin.
ArgatrobanThe serum concentration of Argatroban can be increased when it is combined with Simeprevir.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Simeprevir.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Simeprevir.
ArtemetherThe serum concentration of Artemether can be increased when it is combined with Simeprevir.
ASA404The metabolism of ASA404 can be decreased when combined with Simeprevir.
AsenapineThe serum concentration of Asenapine can be increased when it is combined with Simeprevir.
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Simeprevir.
AsunaprevirThe serum concentration of Simeprevir can be increased when it is combined with Asunaprevir.
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Simeprevir.
AtenololThe serum concentration of Simeprevir can be increased when it is combined with Atenolol.
AtomoxetineThe serum concentration of Simeprevir can be increased when it is combined with Atomoxetine.
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Simeprevir.
AV650The metabolism of AV650 can be decreased when combined with Simeprevir.
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Simeprevir.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Simeprevir.
AzelastineThe serum concentration of Azelastine can be increased when it is combined with Simeprevir.
AzithromycinThe serum concentration of Azithromycin can be increased when it is combined with Simeprevir.
BanoxantroneThe serum concentration of Banoxantrone can be increased when it is combined with Simeprevir.
BatimastatThe serum concentration of Simeprevir can be increased when it is combined with Batimastat.
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Simeprevir.
BenazeprilThe serum concentration of Simeprevir can be increased when it is combined with Benazepril.
BendamustineThe metabolism of Bendamustine can be decreased when combined with Simeprevir.
BenzamidineThe serum concentration of Simeprevir can be increased when it is combined with Benzamidine.
BenzocaineThe serum concentration of Simeprevir can be increased when it is combined with Benzocaine.
BenzphetamineThe serum concentration of Benzphetamine can be increased when it is combined with Simeprevir.
Benzyl alcoholThe serum concentration of Benzyl alcohol can be increased when it is combined with Simeprevir.
BepridilThe serum concentration of Simeprevir can be increased when it is combined with Bepridil.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Simeprevir.
BetaxololThe metabolism of Betaxolol can be decreased when combined with Simeprevir.
BexaroteneThe serum concentration of Bexarotene can be increased when it is combined with Simeprevir.
BexaroteneThe serum concentration of Simeprevir can be decreased when it is combined with Bexarotene.
BezafibrateThe serum concentration of Bezafibrate can be increased when it is combined with Simeprevir.
BicalutamideThe serum concentration of Bicalutamide can be increased when it is combined with Simeprevir.
BiperidenThe serum concentration of Simeprevir can be increased when it is combined with Biperiden.
BisoprololThe serum concentration of Bisoprolol can be increased when it is combined with Simeprevir.
BivalirudinThe serum concentration of Simeprevir can be increased when it is combined with Bivalirudin.
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Simeprevir.
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Simeprevir.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Simeprevir.
BosentanThe serum concentration of Simeprevir can be decreased when it is combined with Bosentan.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Simeprevir.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Simeprevir.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Simeprevir.
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Simeprevir.
BromazepamThe serum concentration of Bromazepam can be increased when it is combined with Simeprevir.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Simeprevir.
BrompheniramineThe serum concentration of Brompheniramine can be increased when it is combined with Simeprevir.
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Simeprevir.
BupivacaineThe serum concentration of Bupivacaine can be increased when it is combined with Simeprevir.
BuprenorphineThe serum concentration of Buprenorphine can be increased when it is combined with Simeprevir.
BupropionThe serum concentration of Bupropion can be increased when it is combined with Simeprevir.
BuspironeThe serum concentration of Buspirone can be increased when it is combined with Simeprevir.
BusulfanThe serum concentration of Busulfan can be increased when it is combined with Simeprevir.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Simeprevir.
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Simeprevir.
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Simeprevir.
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Simeprevir.
CalcitriolThe serum concentration of Calcitriol can be increased when it is combined with Simeprevir.
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Simeprevir.
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Simeprevir.
CandesartanThe serum concentration of Simeprevir can be increased when it is combined with Candesartan.
CandoxatrilThe serum concentration of Simeprevir can be increased when it is combined with Candoxatril.
CaptoprilThe serum concentration of Simeprevir can be increased when it is combined with Captopril.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Simeprevir.
CarbamazepineThe serum concentration of Simeprevir can be decreased when it is combined with Carbamazepine.
CarbinoxamineThe serum concentration of Carbinoxamine can be increased when it is combined with Simeprevir.
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Simeprevir.
CariprazineThe serum concentration of Cariprazine can be increased when it is combined with Simeprevir.
CarmustineThe metabolism of Carmustine can be decreased when combined with Simeprevir.
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Simeprevir.
CaspofunginThe serum concentration of Simeprevir can be increased when it is combined with Caspofungin.
CelecoxibThe serum concentration of Celecoxib can be increased when it is combined with Simeprevir.
CeliprololThe serum concentration of Celiprolol can be increased when it is combined with Simeprevir.
CephalexinThe serum concentration of Cephalexin can be increased when it is combined with Simeprevir.
CeritinibThe serum concentration of Simeprevir can be increased when it is combined with Ceritinib.
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Simeprevir.
CevimelineThe serum concentration of Cevimeline can be increased when it is combined with Simeprevir.
Chenodeoxycholic acidThe serum concentration of Chenodeoxycholic acid can be increased when it is combined with Simeprevir.
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be increased when it is combined with Simeprevir.
ChloroquineThe serum concentration of Chloroquine can be increased when it is combined with Simeprevir.
ChlorphenamineThe serum concentration of Chlorphenamine can be increased when it is combined with Simeprevir.
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Simeprevir.
ChlorpropamideThe serum concentration of Simeprevir can be increased when it is combined with Chlorpropamide.
ChlorprothixeneThe serum concentration of Simeprevir can be increased when it is combined with Chlorprothixene.
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be increased when it is combined with Simeprevir.
CholecalciferolThe serum concentration of Cholecalciferol can be increased when it is combined with Simeprevir.
CholesterolThe serum concentration of Simeprevir can be increased when it is combined with Cholesterol.
Cholic AcidThe serum concentration of Simeprevir can be decreased when it is combined with Cholic Acid.
ChymostatinThe serum concentration of Simeprevir can be increased when it is combined with Chymostatin.
CiclesonideThe serum concentration of Ciclesonide can be increased when it is combined with Simeprevir.
CilastatinThe serum concentration of Simeprevir can be increased when it is combined with Cilastatin.
CilazaprilThe serum concentration of Simeprevir can be increased when it is combined with Cilazapril.
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Simeprevir.
CimetidineThe serum concentration of Simeprevir can be decreased when it is combined with Cimetidine.
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Simeprevir.
CinacalcetThe serum concentration of Cinacalcet can be increased when it is combined with Simeprevir.
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Simeprevir.
CiprofloxacinThe serum concentration of Simeprevir can be increased when it is combined with Ciprofloxacin.
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Simeprevir.
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Simeprevir.
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Simeprevir.
ClarithromycinThe serum concentration of Clarithromycin can be increased when it is combined with Simeprevir.
ClemastineThe serum concentration of Simeprevir can be increased when it is combined with Clemastine.
ClenbuterolThe metabolism of Clenbuterol can be decreased when combined with Simeprevir.
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Simeprevir.
ClindamycinThe serum concentration of Clindamycin can be increased when it is combined with Simeprevir.
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Simeprevir.
ClofazimineThe serum concentration of Clofazimine can be increased when it is combined with Simeprevir.
ClofibrateThe serum concentration of Clofibrate can be increased when it is combined with Simeprevir.
clomethiazoleThe serum concentration of clomethiazole can be increased when it is combined with Simeprevir.
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Simeprevir.
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Simeprevir.
ClonazepamThe serum concentration of Clonazepam can be increased when it is combined with Simeprevir.
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Simeprevir.
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Simeprevir.
ClorazepateThe serum concentration of Clorazepate can be increased when it is combined with Simeprevir.
ClotiazepamThe serum concentration of Clotiazepam can be increased when it is combined with Simeprevir.
ClotrimazoleThe serum concentration of Simeprevir can be increased when it is combined with Clotrimazole.
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Simeprevir.
CobicistatThe serum concentration of Simeprevir can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Simeprevir.
CocaineThe serum concentration of Cocaine can be increased when it is combined with Simeprevir.
CodeineThe serum concentration of Codeine can be increased when it is combined with Simeprevir.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Simeprevir.
ColforsinThe serum concentration of Simeprevir can be increased when it is combined with Colforsin.
ConivaptanThe serum concentration of Simeprevir can be increased when it is combined with Conivaptan.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Simeprevir.
Cortisone acetateThe serum concentration of Cortisone acetate can be increased when it is combined with Simeprevir.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Simeprevir.
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Simeprevir.
CyclophosphamideThe serum concentration of Cyclophosphamide can be increased when it is combined with Simeprevir.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Simeprevir.
CytarabineThe serum concentration of Cytarabine can be increased when it is combined with Simeprevir.
Dabigatran etexilateThe serum concentration of Simeprevir can be increased when it is combined with Dabigatran etexilate.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Simeprevir.
DabrafenibThe serum concentration of Simeprevir can be decreased when it is combined with Dabrafenib.
DacarbazineThe metabolism of Dacarbazine can be decreased when combined with Simeprevir.
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Simeprevir.
DactinomycinThe serum concentration of Simeprevir can be increased when it is combined with Dactinomycin.
DantroleneThe serum concentration of Dantrolene can be increased when it is combined with Simeprevir.
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Simeprevir.
DapsoneThe serum concentration of Dapsone can be increased when it is combined with Simeprevir.
DarifenacinThe serum concentration of Darifenacin can be increased when it is combined with Simeprevir.
DarunavirThe serum concentration of Darunavir can be increased when it is combined with Simeprevir.
DasabuvirThe serum concentration of Dasabuvir can be increased when it is combined with Simeprevir.
DasatinibThe serum concentration of Simeprevir can be increased when it is combined with Dasatinib.
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Simeprevir.
DaunorubicinThe serum concentration of Simeprevir can be decreased when it is combined with Daunorubicin.
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Simeprevir.
DeferasiroxThe serum concentration of Simeprevir can be decreased when it is combined with Deferasirox.
DehydroepiandrosteroneThe serum concentration of Dehydroepiandrosterone can be increased when it is combined with Simeprevir.
DelavirdineThe serum concentration of Delavirdine can be increased when it is combined with Simeprevir.
DesipramineThe serum concentration of Desipramine can be increased when it is combined with Simeprevir.
DesloratadineThe serum concentration of Simeprevir can be increased when it is combined with Desloratadine.
DesvenlafaxineThe serum concentration of Desvenlafaxine can be increased when it is combined with Simeprevir.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Simeprevir.
DexamethasoneThe serum concentration of Simeprevir can be decreased when it is combined with Dexamethasone.
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Simeprevir.
DexketoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Simeprevir.
DextromethorphanThe serum concentration of Dextromethorphan can be increased when it is combined with Simeprevir.
DextropropoxypheneThe serum concentration of Dextropropoxyphene can be increased when it is combined with Simeprevir.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Simeprevir.
DiclofenacThe serum concentration of Diclofenac can be increased when it is combined with Simeprevir.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Simeprevir.
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Simeprevir.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Simeprevir.
DigoxinThe serum concentration of Simeprevir can be decreased when it is combined with Digoxin.
DihydrocodeineThe serum concentration of Dihydrocodeine can be increased when it is combined with Simeprevir.
DihydroergotamineThe serum concentration of Simeprevir can be increased when it is combined with Dihydroergotamine.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Simeprevir.
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Simeprevir.
DinoprostoneThe metabolism of Dinoprostone can be decreased when combined with Simeprevir.
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Simeprevir.
DipyridamoleThe serum concentration of Simeprevir can be increased when it is combined with Dipyridamole.
DisopyramideThe serum concentration of Disopyramide can be increased when it is combined with Simeprevir.
DisulfiramThe serum concentration of Disulfiram can be increased when it is combined with Simeprevir.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Simeprevir.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Simeprevir.
DolasetronThe serum concentration of Dolasetron can be increased when it is combined with Simeprevir.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Simeprevir.
DonepezilThe serum concentration of Donepezil can be increased when it is combined with Simeprevir.
DorzolamideThe serum concentration of Dorzolamide can be increased when it is combined with Simeprevir.
DosulepinThe serum concentration of Dosulepin can be increased when it is combined with Simeprevir.
DoxazosinThe serum concentration of Simeprevir can be increased when it is combined with Doxazosin.
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Simeprevir.
DoxorubicinThe serum concentration of Simeprevir can be decreased when it is combined with Doxorubicin.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Simeprevir.
DoxycyclineThe serum concentration of Simeprevir can be increased when it is combined with Doxycycline.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Simeprevir.
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Simeprevir.
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Simeprevir.
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Simeprevir.
DyphyllineThe serum concentration of Dyphylline can be decreased when it is combined with Simeprevir.
EcabetThe serum concentration of Simeprevir can be increased when it is combined with Ecabet.
EdoxabanThe serum concentration of Simeprevir can be increased when it is combined with Edoxaban.
EfavirenzThe serum concentration of Efavirenz can be increased when it is combined with Simeprevir.
EfavirenzThe serum concentration of Simeprevir can be decreased when it is combined with Efavirenz.
ElafinThe serum concentration of Simeprevir can be increased when it is combined with Elafin.
ElbasvirThe serum concentration of Simeprevir can be increased when it is combined with Elbasvir.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Simeprevir.
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Simeprevir.
EltrombopagThe serum concentration of Simeprevir can be increased when it is combined with Eltrombopag.
EltrombopagThe metabolism of Eltrombopag can be decreased when combined with Simeprevir.
ElvitegravirThe serum concentration of Elvitegravir can be increased when it is combined with Simeprevir.
EnalaprilThe serum concentration of Enalapril can be increased when it is combined with Simeprevir.
EnalaprilatThe serum concentration of Simeprevir can be increased when it is combined with Enalaprilat.
EnalkirenThe serum concentration of Simeprevir can be increased when it is combined with Enalkiren.
EnfuvirtideThe serum concentration of Enfuvirtide can be increased when it is combined with Simeprevir.
EnzalutamideThe serum concentration of Enzalutamide can be increased when it is combined with Simeprevir.
EnzalutamideThe serum concentration of Simeprevir can be decreased when it is combined with Enzalutamide.
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Simeprevir.
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Simeprevir.
ErgocalciferolThe serum concentration of Ergocalciferol can be increased when it is combined with Simeprevir.
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Simeprevir.
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Simeprevir.
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Simeprevir.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Simeprevir.
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Simeprevir.
EscitalopramThe serum concentration of Escitalopram can be increased when it is combined with Simeprevir.
EscitalopramThe serum concentration of Simeprevir can be decreased when it is combined with Escitalopram.
Eslicarbazepine acetateThe serum concentration of Simeprevir can be decreased when it is combined with Eslicarbazepine acetate.
EsmirtazapineThe serum concentration of Esmirtazapine can be increased when it is combined with Simeprevir.
EsomeprazoleThe serum concentration of Esomeprazole can be increased when it is combined with Simeprevir.
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Simeprevir.
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Simeprevir.
Estradiol valerate/DienogestThe serum concentration of Estradiol valerate/Dienogest can be increased when it is combined with Simeprevir.
EstramustineThe serum concentration of Estramustine can be increased when it is combined with Simeprevir.
EstriolThe serum concentration of Simeprevir can be decreased when it is combined with Estriol.
EstriolThe serum concentration of Estriol can be increased when it is combined with Simeprevir.
EstroneThe serum concentration of Estrone can be increased when it is combined with Simeprevir.
EstroneThe serum concentration of Simeprevir can be decreased when it is combined with Estrone.
Estrone sulfateThe serum concentration of Estrone sulfate can be increased when it is combined with Simeprevir.
EszopicloneThe serum concentration of Eszopiclone can be increased when it is combined with Simeprevir.
EthanolThe serum concentration of Ethanol can be increased when it is combined with Simeprevir.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Simeprevir.
EthosuximideThe serum concentration of Ethosuximide can be increased when it is combined with Simeprevir.
EthylmorphineThe serum concentration of Ethylmorphine can be increased when it is combined with Simeprevir.
EtonogestrelThe serum concentration of Etonogestrel can be increased when it is combined with Simeprevir.
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Simeprevir.
EtoricoxibThe serum concentration of Etoricoxib can be increased when it is combined with Simeprevir.
EtravirineThe serum concentration of Etravirine can be increased when it is combined with Simeprevir.
EtravirineThe serum concentration of Simeprevir can be decreased when it is combined with Etravirine.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Simeprevir.
ExemestaneThe serum concentration of Exemestane can be increased when it is combined with Simeprevir.
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Simeprevir.
FamciclovirThe serum concentration of Famciclovir can be increased when it is combined with Simeprevir.
FelbamateThe serum concentration of Felbamate can be increased when it is combined with Simeprevir.
FelodipineThe serum concentration of Felodipine can be increased when it is combined with Simeprevir.
FenofibrateThe serum concentration of Fenofibrate can be increased when it is combined with Simeprevir.
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Simeprevir.
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Simeprevir.
FexofenadineThe serum concentration of Simeprevir can be increased when it is combined with Fexofenadine.
FidaxomicinThe serum concentration of Simeprevir can be increased when it is combined with Fidaxomicin.
FinasterideThe serum concentration of Finasteride can be increased when it is combined with Simeprevir.
FingolimodThe serum concentration of Fingolimod can be increased when it is combined with Simeprevir.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Simeprevir.
FluconazoleThe serum concentration of Simeprevir can be increased when it is combined with Fluconazole.
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Simeprevir.
FlunisolideThe serum concentration of Flunisolide can be increased when it is combined with Simeprevir.
FlunitrazepamThe serum concentration of Flunitrazepam can be increased when it is combined with Simeprevir.
FluorometholoneThe serum concentration of Fluorometholone can be increased when it is combined with Simeprevir.
FluorouracilThe metabolism of Fluorouracil can be decreased when combined with Simeprevir.
FluoxetineThe serum concentration of Fluoxetine can be increased when it is combined with Simeprevir.
FlupentixolThe serum concentration of Simeprevir can be increased when it is combined with Flupentixol.
FluphenazineThe serum concentration of Simeprevir can be increased when it is combined with Fluphenazine.
FlurazepamThe serum concentration of Flurazepam can be increased when it is combined with Simeprevir.
FlutamideThe serum concentration of Flutamide can be increased when it is combined with Simeprevir.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Simeprevir.
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Simeprevir.
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Simeprevir.
FluvoxamineThe serum concentration of Simeprevir can be increased when it is combined with Fluvoxamine.
FluvoxamineThe metabolism of Fluvoxamine can be decreased when combined with Simeprevir.
FosamprenavirThe serum concentration of Fosamprenavir can be increased when it is combined with Simeprevir.
FosaprepitantThe serum concentration of Simeprevir can be increased when it is combined with Fosaprepitant.
FosinoprilThe serum concentration of Simeprevir can be increased when it is combined with Fosinopril.
FosphenytoinThe serum concentration of Simeprevir can be decreased when it is combined with Fosphenytoin.
FrovatriptanThe metabolism of Frovatriptan can be decreased when combined with Simeprevir.
FulvestrantThe serum concentration of Fulvestrant can be increased when it is combined with Simeprevir.
Fusidic AcidThe serum concentration of Simeprevir can be increased when it is combined with Fusidic Acid.
GalantamineThe serum concentration of Galantamine can be increased when it is combined with Simeprevir.
GarlicThe serum concentration of Simeprevir can be decreased when it is combined with Garlic.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Simeprevir.
GeldanamycinThe serum concentration of Simeprevir can be increased when it is combined with Geldanamycin.
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Simeprevir.
GemfibrozilThe serum concentration of Gemfibrozil can be increased when it is combined with Simeprevir.
GenisteinThe serum concentration of Simeprevir can be increased when it is combined with Genistein.
GenisteinThe metabolism of Genistein can be decreased when combined with Simeprevir.
GlipizideThe serum concentration of Glipizide can be increased when it is combined with Simeprevir.
GlyburideThe serum concentration of Glyburide can be increased when it is combined with Simeprevir.
GlycerolThe serum concentration of Simeprevir can be increased when it is combined with Glycerol.
GM6001The serum concentration of Simeprevir can be increased when it is combined with GM6001.
Gramicidin DThe serum concentration of Simeprevir can be increased when it is combined with Gramicidin D.
GranisetronThe serum concentration of Granisetron can be increased when it is combined with Simeprevir.
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Simeprevir.
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Simeprevir.
GuanabenzThe metabolism of Guanabenz can be decreased when combined with Simeprevir.
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Simeprevir.
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Simeprevir.
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Simeprevir.
HalothaneThe serum concentration of Halothane can be increased when it is combined with Simeprevir.
HesperetinThe metabolism of Hesperetin can be decreased when combined with Simeprevir.
HexobarbitalThe serum concentration of Hexobarbital can be increased when it is combined with Simeprevir.
HirulogThe serum concentration of Simeprevir can be increased when it is combined with Hirulog.
Histamine PhosphateThe serum concentration of Histamine Phosphate can be increased when it is combined with Simeprevir.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Simeprevir.
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Simeprevir.
HydromorphoneThe serum concentration of Hydromorphone can be increased when it is combined with Simeprevir.
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be increased when it is combined with Simeprevir.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Simeprevir.
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Simeprevir.
IdelalisibThe serum concentration of Simeprevir can be increased when it is combined with Idelalisib.
IfosfamideThe serum concentration of Ifosfamide can be increased when it is combined with Simeprevir.
IloperidoneThe serum concentration of Iloperidone can be increased when it is combined with Simeprevir.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Simeprevir.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Simeprevir.
ImiquimodThe serum concentration of Imiquimod can be increased when it is combined with Simeprevir.
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Simeprevir.
IndapamideThe serum concentration of Indapamide can be increased when it is combined with Simeprevir.
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Simeprevir.
IndomethacinThe serum concentration of Simeprevir can be increased when it is combined with Indomethacin.
Ipratropium bromideThe serum concentration of Ipratropium bromide can be increased when it is combined with Simeprevir.
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Simeprevir.
IsavuconazoniumThe serum concentration of Isavuconazonium can be increased when it is combined with Simeprevir.
IsoflurophateThe serum concentration of Simeprevir can be increased when it is combined with Isoflurophate.
Isosorbide DinitrateThe serum concentration of Isosorbide Dinitrate can be increased when it is combined with Simeprevir.
Isosorbide MononitrateThe serum concentration of Isosorbide Mononitrate can be increased when it is combined with Simeprevir.
IsradipineThe serum concentration of Isradipine can be increased when it is combined with Simeprevir.
ItraconazoleThe serum concentration of Itraconazole can be increased when it is combined with Simeprevir.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Simeprevir.
IvacaftorThe serum concentration of Simeprevir can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Simeprevir.
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Simeprevir.
IxazomibThe serum concentration of Ixazomib can be increased when it is combined with Simeprevir.
KetamineThe serum concentration of Ketamine can be increased when it is combined with Simeprevir.
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Simeprevir.
KetobemidoneThe serum concentration of Ketobemidone can be increased when it is combined with Simeprevir.
KetoconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Simeprevir.
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Simeprevir.
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Simeprevir.
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Simeprevir.
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Simeprevir.
LaquinimodThe serum concentration of Laquinimod can be increased when it is combined with Simeprevir.
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Simeprevir.
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Simeprevir.
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Simeprevir.
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Simeprevir.
LepirudinThe serum concentration of Simeprevir can be increased when it is combined with Lepirudin.
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Simeprevir.
LetrozoleThe serum concentration of Letrozole can be increased when it is combined with Simeprevir.
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Simeprevir.
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Simeprevir.
LevocetirizineThe serum concentration of Levocetirizine can be increased when it is combined with Simeprevir.
LevofloxacinThe serum concentration of Simeprevir can be increased when it is combined with Levofloxacin.
Levomethadyl AcetateThe serum concentration of Levomethadyl Acetate can be increased when it is combined with Simeprevir.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Simeprevir.
LevonorgestrelThe serum concentration of Levonorgestrel can be increased when it is combined with Simeprevir.
LevothyroxineThe serum concentration of Levothyroxine can be increased when it is combined with Simeprevir.
LevothyroxineThe serum concentration of Simeprevir can be decreased when it is combined with Levothyroxine.
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Simeprevir.
LinagliptinThe serum concentration of Simeprevir can be increased when it is combined with Linagliptin.
LiothyronineThe serum concentration of Simeprevir can be decreased when it is combined with Liothyronine.
LiotrixThe serum concentration of Simeprevir can be decreased when it is combined with Liotrix.
LisinoprilThe serum concentration of Simeprevir can be increased when it is combined with Lisinopril.
LisurideThe serum concentration of Lisuride can be increased when it is combined with Simeprevir.
LomefloxacinThe metabolism of Lomefloxacin can be decreased when combined with Simeprevir.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Simeprevir.
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Simeprevir.
LopinavirThe serum concentration of Lopinavir can be increased when it is combined with Simeprevir.
LoratadineThe serum concentration of Loratadine can be increased when it is combined with Simeprevir.
LorcaserinThe serum concentration of Lorcaserin can be increased when it is combined with Simeprevir.
LosartanThe serum concentration of Losartan can be increased when it is combined with Simeprevir.
LovastatinThe serum concentration of Simeprevir can be increased when it is combined with Lovastatin.
LuliconazoleThe serum concentration of Simeprevir can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Simeprevir can be decreased when it is combined with Lumacaftor.
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Simeprevir.
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Simeprevir.
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Simeprevir.
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Simeprevir.
MalathionThe metabolism of Malathion can be decreased when combined with Simeprevir.
MannitolThe serum concentration of Mannitol can be increased when it is combined with Simeprevir.
MaprotilineThe serum concentration of Simeprevir can be increased when it is combined with Maprotiline.
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Simeprevir.
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Simeprevir.
MebendazoleThe serum concentration of Mebendazole can be increased when it is combined with Simeprevir.
MecamylamineThe risk or severity of adverse effects can be increased when Simeprevir is combined with Mecamylamine.
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Simeprevir.
MefloquineThe serum concentration of Mefloquine can be increased when it is combined with Simeprevir.
Megestrol acetateThe serum concentration of Simeprevir can be increased when it is combined with Megestrol acetate.
MelatoninThe metabolism of Melatonin can be decreased when combined with Simeprevir.
MeloxicamThe serum concentration of Meloxicam can be increased when it is combined with Simeprevir.
MenadioneThe metabolism of Menadione can be decreased when combined with Simeprevir.
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Simeprevir.
MeprobamateThe serum concentration of Simeprevir can be increased when it is combined with Meprobamate.
MethadoneThe serum concentration of Methadone can be increased when it is combined with Simeprevir.
MethaqualoneThe serum concentration of Methaqualone can be increased when it is combined with Simeprevir.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Simeprevir.
MethoxsalenThe serum concentration of Methoxsalen can be increased when it is combined with Simeprevir.
MethoxyfluraneThe serum concentration of Methoxyflurane can be increased when it is combined with Simeprevir.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Simeprevir.
MethyltestosteroneThe serum concentration of Methyltestosterone can be increased when it is combined with Simeprevir.
MetoprololThe serum concentration of Simeprevir can be increased when it is combined with Metoprolol.
MetronidazoleThe serum concentration of Metronidazole can be increased when it is combined with Simeprevir.
MexiletineThe serum concentration of Mexiletine can be increased when it is combined with Simeprevir.
MianserinThe serum concentration of Mianserin can be increased when it is combined with Simeprevir.
MibefradilThe serum concentration of Mibefradil can be increased when it is combined with Simeprevir.
MiconazoleThe serum concentration of Miconazole can be increased when it is combined with Simeprevir.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Simeprevir.
MidazolamThe serum concentration of Simeprevir can be decreased when it is combined with Midazolam.
MifepristoneThe serum concentration of Mifepristone can be increased when it is combined with Simeprevir.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Simeprevir.
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Simeprevir.
MitomycinThe serum concentration of Simeprevir can be increased when it is combined with Mitomycin.
MitotaneThe serum concentration of Simeprevir can be decreased when it is combined with Mitotane.
MitoxantroneThe serum concentration of Simeprevir can be decreased when it is combined with Mitoxantrone.
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Simeprevir.
ModafinilThe serum concentration of Modafinil can be increased when it is combined with Simeprevir.
ModafinilThe serum concentration of Simeprevir can be decreased when it is combined with Modafinil.
MoexiprilThe serum concentration of Simeprevir can be increased when it is combined with Moexipril.
MontelukastThe serum concentration of Montelukast can be increased when it is combined with Simeprevir.
MorphineThe serum concentration of Morphine can be increased when it is combined with Simeprevir.
muraglitazarThe metabolism of muraglitazar can be decreased when combined with Simeprevir.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Simeprevir.
N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-ProlineThe serum concentration of Simeprevir can be increased when it is combined with N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline.
NabumetoneThe metabolism of Nabumetone can be decreased when combined with Simeprevir.
NadololThe serum concentration of Nadolol can be increased when it is combined with Simeprevir.
NafcillinThe serum concentration of Simeprevir can be decreased when it is combined with Nafcillin.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Simeprevir.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Simeprevir.
NaltrexoneThe serum concentration of Simeprevir can be increased when it is combined with Naltrexone.
NaproxenThe metabolism of Naproxen can be decreased when combined with Simeprevir.
NaringeninThe serum concentration of Simeprevir can be increased when it is combined with Naringenin.
NateglinideThe serum concentration of Nateglinide can be increased when it is combined with Simeprevir.
NCX 4016The serum concentration of Simeprevir can be increased when it is combined with NCX 4016.
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Simeprevir.
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Simeprevir.
NeostigmineThe serum concentration of Simeprevir can be increased when it is combined with Neostigmine.
NetupitantThe serum concentration of Simeprevir can be increased when it is combined with Netupitant.
NevirapineThe serum concentration of Nevirapine can be increased when it is combined with Simeprevir.
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Simeprevir.
NicotineThe serum concentration of Nicotine can be increased when it is combined with Simeprevir.
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Simeprevir.
NifedipineThe serum concentration of Simeprevir can be decreased when it is combined with Nifedipine.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Simeprevir.
NilvadipineThe serum concentration of Nilvadipine can be increased when it is combined with Simeprevir.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Simeprevir.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Simeprevir.
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Simeprevir.
NitrazepamThe serum concentration of Nitrazepam can be increased when it is combined with Simeprevir.
NitrendipineThe serum concentration of Nitrendipine can be increased when it is combined with Simeprevir.
Nitric OxideThe metabolism of Nitric Oxide can be decreased when combined with Simeprevir.
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Simeprevir.
NorethisteroneThe serum concentration of Norethisterone can be increased when it is combined with Simeprevir.
NorethisteroneThe serum concentration of Simeprevir can be decreased when it is combined with Norethisterone.
NorgestrelThe serum concentration of Norgestrel can be increased when it is combined with Simeprevir.
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Simeprevir.
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Simeprevir.
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Simeprevir.
OlopatadineThe serum concentration of Olopatadine can be increased when it is combined with Simeprevir.
OmapatrilatThe serum concentration of Simeprevir can be increased when it is combined with Omapatrilat.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Simeprevir.
OmeprazoleThe serum concentration of Omeprazole can be increased when it is combined with Simeprevir.
OndansetronThe serum concentration of Ondansetron can be increased when it is combined with Simeprevir.
OrphenadrineThe serum concentration of Orphenadrine can be increased when it is combined with Simeprevir.
OsimertinibThe serum concentration of Simeprevir can be increased when it is combined with Osimertinib.
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Simeprevir.
OtamixabanThe serum concentration of Simeprevir can be increased when it is combined with Otamixaban.
OxaliplatinThe metabolism of Oxaliplatin can be decreased when combined with Simeprevir.
OxazepamThe serum concentration of Oxazepam can be increased when it is combined with Simeprevir.
OxtriphyllineThe metabolism of Oxtriphylline can be decreased when combined with Simeprevir.
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Simeprevir.
OxycodoneThe serum concentration of Oxycodone can be increased when it is combined with Simeprevir.
OxymorphoneThe serum concentration of Oxymorphone can be increased when it is combined with Simeprevir.
P-NitrophenolThe serum concentration of Simeprevir can be increased when it is combined with P-Nitrophenol.
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Simeprevir.
PalbociclibThe serum concentration of Simeprevir can be increased when it is combined with Palbociclib.
Palmitic AcidThe serum concentration of Simeprevir can be increased when it is combined with Palmitic Acid.
PalonosetronThe serum concentration of Palonosetron can be increased when it is combined with Simeprevir.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Simeprevir.
PantoprazoleThe serum concentration of Pantoprazole can be increased when it is combined with Simeprevir.
ParamethadioneThe serum concentration of Paramethadione can be increased when it is combined with Simeprevir.
ParamethasoneThe serum concentration of Paramethasone can be increased when it is combined with Simeprevir.
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Simeprevir.
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Simeprevir.
ParitaprevirThe serum concentration of Paritaprevir can be increased when it is combined with Simeprevir.
ParoxetineThe serum concentration of Simeprevir can be increased when it is combined with Paroxetine.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Simeprevir.
PentamidineThe serum concentration of Pentamidine can be increased when it is combined with Simeprevir.
PentobarbitalThe serum concentration of Simeprevir can be decreased when it is combined with Pentobarbital.
PentoxifyllineThe metabolism of Pentoxifylline can be decreased when combined with Simeprevir.
PerampanelThe serum concentration of Perampanel can be increased when it is combined with Simeprevir.
PergolideThe serum concentration of Pergolide can be increased when it is combined with Simeprevir.
PerhexilineThe serum concentration of Perhexiline can be increased when it is combined with Simeprevir.
PerindoprilThe serum concentration of Simeprevir can be increased when it is combined with Perindopril.
PermethrinThe serum concentration of Permethrin can be increased when it is combined with Simeprevir.
PerphenazineThe serum concentration of Perphenazine can be increased when it is combined with Simeprevir.
PethidineThe serum concentration of Pethidine can be increased when it is combined with Simeprevir.
PhenacetinThe serum concentration of Phenacetin can be increased when it is combined with Simeprevir.
PhenobarbitalThe serum concentration of Simeprevir can be decreased when it is combined with Phenobarbital.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Simeprevir.
PhenoxybenzamineThe serum concentration of Phenoxybenzamine can be increased when it is combined with Simeprevir.
PhenprocoumonThe serum concentration of Phenprocoumon can be increased when it is combined with Simeprevir.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Simeprevir.
PhenytoinThe serum concentration of Simeprevir can be decreased when it is combined with Phenytoin.
PhosphoramidonThe serum concentration of Simeprevir can be increased when it is combined with Phosphoramidon.
PilocarpineThe serum concentration of Pilocarpine can be increased when it is combined with Simeprevir.
PimecrolimusThe serum concentration of Pimecrolimus can be increased when it is combined with Simeprevir.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Simeprevir.
PinacidilThe serum concentration of Pinacidil can be increased when it is combined with Simeprevir.
PioglitazoneThe serum concentration of Pioglitazone can be increased when it is combined with Simeprevir.
PipotiazineThe serum concentration of Pipotiazine can be increased when it is combined with Simeprevir.
PirfenidoneThe serum concentration of Pirfenidone can be increased when it is combined with Simeprevir.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Simeprevir.
Platelet Activating FactorThe serum concentration of Simeprevir can be decreased when it is combined with Platelet Activating Factor.
PodofiloxThe serum concentration of Podofilox can be increased when it is combined with Simeprevir.
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Simeprevir.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Simeprevir.
PosaconazoleThe serum concentration of Posaconazole can be increased when it is combined with Simeprevir.
PrasugrelThe serum concentration of Prasugrel can be increased when it is combined with Simeprevir.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Simeprevir.
PrazepamThe serum concentration of Prazepam can be increased when it is combined with Simeprevir.
PraziquantelThe serum concentration of Praziquantel can be increased when it is combined with Simeprevir.
PrazosinThe serum concentration of Simeprevir can be increased when it is combined with Prazosin.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Simeprevir.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Simeprevir.
PrimaquineThe serum concentration of Primaquine can be increased when it is combined with Simeprevir.
PrimidoneThe serum concentration of Simeprevir can be decreased when it is combined with Primidone.
PrinomastatThe serum concentration of Simeprevir can be increased when it is combined with Prinomastat.
ProbenecidThe serum concentration of Simeprevir can be increased when it is combined with Probenecid.
ProchlorperazineThe serum concentration of Prochlorperazine can be increased when it is combined with Simeprevir.
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Simeprevir.
ProgesteroneThe serum concentration of Simeprevir can be decreased when it is combined with Progesterone.
ProguanilThe serum concentration of Proguanil can be increased when it is combined with Simeprevir.
PromazineThe serum concentration of Promazine can be increased when it is combined with Simeprevir.
PromethazineThe serum concentration of Simeprevir can be increased when it is combined with Promethazine.
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Simeprevir.
PropofolThe serum concentration of Propofol can be increased when it is combined with Simeprevir.
PropranololThe serum concentration of Propranolol can be increased when it is combined with Simeprevir.
ProtriptylineThe serum concentration of Protriptyline can be increased when it is combined with Simeprevir.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Simeprevir.
PyrazinamideThe serum concentration of Pyrazinamide can be increased when it is combined with Simeprevir.
QuazepamThe serum concentration of Quazepam can be increased when it is combined with Simeprevir.
QuercetinThe serum concentration of Simeprevir can be increased when it is combined with Quercetin.
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Simeprevir.
QuinacrineThe serum concentration of Quinacrine can be increased when it is combined with Simeprevir.
QuinaprilThe serum concentration of Simeprevir can be increased when it is combined with Quinapril.
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Simeprevir.
QuinineThe serum concentration of Quinine can be increased when it is combined with Simeprevir.
RabeprazoleThe serum concentration of Rabeprazole can be increased when it is combined with Simeprevir.
RaloxifeneThe serum concentration of Raloxifene can be increased when it is combined with Simeprevir.
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Simeprevir.
RamiprilThe serum concentration of Simeprevir can be increased when it is combined with Ramipril.
RanitidineThe serum concentration of Simeprevir can be increased when it is combined with Ranitidine.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Simeprevir.
RasagilineThe metabolism of Rasagiline can be decreased when combined with Simeprevir.
ReboxetineThe serum concentration of Reboxetine can be increased when it is combined with Simeprevir.
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Simeprevir.
RemikirenThe serum concentration of Simeprevir can be increased when it is combined with Remikiren.
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Simeprevir.
ReserpineThe serum concentration of Simeprevir can be decreased when it is combined with Reserpine.
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Simeprevir.
ResveratrolThe metabolism of Resveratrol can be decreased when combined with Simeprevir.
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Simeprevir.
RifabutinThe serum concentration of Rifabutin can be increased when it is combined with Simeprevir.
RifabutinThe serum concentration of Simeprevir can be decreased when it is combined with Rifabutin.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Simeprevir.
RifampicinThe serum concentration of Simeprevir can be decreased when it is combined with Rifampicin.
RifapentineThe serum concentration of Simeprevir can be decreased when it is combined with Rifapentine.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Simeprevir.
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Simeprevir.
RiluzoleThe metabolism of Riluzole can be decreased when combined with Simeprevir.
RimonabantThe serum concentration of Rimonabant can be increased when it is combined with Simeprevir.
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Simeprevir.
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Simeprevir.
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Simeprevir.
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Simeprevir.
RizatriptanThe metabolism of Rizatriptan can be decreased when combined with Simeprevir.
RofecoxibThe serum concentration of Rofecoxib can be increased when it is combined with Simeprevir.
RolapitantThe serum concentration of Rolapitant can be increased when it is combined with Simeprevir.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Simeprevir.
RopiniroleThe serum concentration of Ropinirole can be increased when it is combined with Simeprevir.
RopivacaineThe serum concentration of Ropivacaine can be increased when it is combined with Simeprevir.
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Simeprevir.
RotigotineThe serum concentration of Rotigotine can be increased when it is combined with Simeprevir.
RoxithromycinThe serum concentration of Roxithromycin can be increased when it is combined with Simeprevir.
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Simeprevir.
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Simeprevir.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Simeprevir.
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Simeprevir.
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Simeprevir.
ScopolamineThe serum concentration of Simeprevir can be increased when it is combined with Scopolamine.
SelegilineThe serum concentration of Selegiline can be increased when it is combined with Simeprevir.
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Simeprevir.
SeratrodastThe serum concentration of Seratrodast can be increased when it is combined with Simeprevir.
SertindoleThe serum concentration of Sertindole can be increased when it is combined with Simeprevir.
SertralineThe serum concentration of Sertraline can be increased when it is combined with Simeprevir.
SevofluraneThe serum concentration of Sevoflurane can be increased when it is combined with Simeprevir.
SibutramineThe serum concentration of Sibutramine can be increased when it is combined with Simeprevir.
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Simeprevir.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Simeprevir.
SiltuximabThe serum concentration of Simeprevir can be decreased when it is combined with Siltuximab.
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Simeprevir.
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Simeprevir.
SirolimusThe serum concentration of Simeprevir can be decreased when it is combined with Sirolimus.
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Simeprevir.
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Simeprevir.
SolifenacinThe serum concentration of Solifenacin can be increased when it is combined with Simeprevir.
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Simeprevir.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Simeprevir.
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Simeprevir.
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Simeprevir.
SpiramycinThe serum concentration of Spiramycin can be increased when it is combined with Simeprevir.
SpiraprilThe serum concentration of Simeprevir can be increased when it is combined with Spirapril.
SpironolactoneThe serum concentration of Simeprevir can be increased when it is combined with Spironolactone.
St. John's WortThe metabolism of Simeprevir can be increased when combined with St. John's Wort.
StaurosporineThe serum concentration of Simeprevir can be increased when it is combined with Staurosporine.
StiripentolThe serum concentration of Simeprevir can be increased when it is combined with Stiripentol.
StreptozocinThe serum concentration of Simeprevir can be decreased when it is combined with Streptozocin.
SufentanilThe serum concentration of Sufentanil can be increased when it is combined with Simeprevir.
SulfadiazineThe serum concentration of Sulfadiazine can be increased when it is combined with Simeprevir.
SulfamethoxazoleThe serum concentration of Sulfamethoxazole can be increased when it is combined with Simeprevir.
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be increased when it is combined with Simeprevir.
SulfisoxazoleThe serum concentration of Simeprevir can be increased when it is combined with Sulfisoxazole.
SumatriptanThe serum concentration of Simeprevir can be increased when it is combined with Sumatriptan.
SunitinibThe serum concentration of Sunitinib can be increased when it is combined with Simeprevir.
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be increased when it is combined with Simeprevir.
Synthetic Conjugated Estrogens, BThe serum concentration of Synthetic Conjugated Estrogens, B can be increased when it is combined with Simeprevir.
TacrineThe serum concentration of Simeprevir can be increased when it is combined with Tacrine.
TacrineThe metabolism of Tacrine can be decreased when combined with Simeprevir.
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Simeprevir.
TacrolimusThe serum concentration of Simeprevir can be decreased when it is combined with Tacrolimus.
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Simeprevir.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Simeprevir.
TamoxifenThe serum concentration of Simeprevir can be decreased when it is combined with Tamoxifen.
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Simeprevir.
TasosartanThe serum concentration of Tasosartan can be increased when it is combined with Simeprevir.
Taurochenodeoxycholic acidThe serum concentration of Taurochenodeoxycholic acid can be increased when it is combined with Simeprevir.
Taurocholic AcidThe serum concentration of Simeprevir can be increased when it is combined with Taurocholic Acid.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Simeprevir.
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Simeprevir.
TelithromycinThe serum concentration of Telithromycin can be increased when it is combined with Simeprevir.
TelmisartanThe serum concentration of Simeprevir can be increased when it is combined with Telmisartan.
TemafloxacinThe metabolism of Temafloxacin can be decreased when combined with Simeprevir.
TemazepamThe serum concentration of Temazepam can be increased when it is combined with Simeprevir.
TemocaprilThe serum concentration of Simeprevir can be increased when it is combined with Temocapril.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Simeprevir.
TeniposideThe serum concentration of Teniposide can be increased when it is combined with Simeprevir.
TenofovirThe serum concentration of Simeprevir can be decreased when it is combined with Tenofovir.
TerazosinThe serum concentration of Simeprevir can be increased when it is combined with Terazosin.
TerbinafineThe serum concentration of Terbinafine can be increased when it is combined with Simeprevir.
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Simeprevir.
TeriflunomideThe serum concentration of Simeprevir can be increased when it is combined with Teriflunomide.
TesmilifeneThe serum concentration of Tesmilifene can be increased when it is combined with Simeprevir.
TesmilifeneThe serum concentration of Simeprevir can be decreased when it is combined with Tesmilifene.
TestosteroneThe serum concentration of Testosterone can be increased when it is combined with Simeprevir.
TetracyclineThe serum concentration of Tetracycline can be increased when it is combined with Simeprevir.
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Simeprevir.
TheobromineThe metabolism of Theobromine can be decreased when combined with Simeprevir.
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Simeprevir.
ThiabendazoleThe metabolism of Thiabendazole can be decreased when combined with Simeprevir.
ThioridazineThe metabolism of Thioridazine can be decreased when combined with Simeprevir.
ThiorphanThe serum concentration of Simeprevir can be increased when it is combined with Thiorphan.
ThiotepaThe serum concentration of Thiotepa can be increased when it is combined with Simeprevir.
ThiothixeneThe metabolism of Thiothixene can be decreased when combined with Simeprevir.
TiagabineThe serum concentration of Tiagabine can be increased when it is combined with Simeprevir.
TianeptineThe serum concentration of Tianeptine can be increased when it is combined with Simeprevir.
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Simeprevir.
TiclopidineThe serum concentration of Ticlopidine can be increased when it is combined with Simeprevir.
TimololThe serum concentration of Timolol can be increased when it is combined with Simeprevir.
TinidazoleThe serum concentration of Tinidazole can be increased when it is combined with Simeprevir.
TiotropiumThe serum concentration of Tiotropium can be increased when it is combined with Simeprevir.
TipranavirThe serum concentration of Tipranavir can be increased when it is combined with Simeprevir.
TizanidineThe serum concentration of Tizanidine can be increased when it is combined with Simeprevir.
TocilizumabThe serum concentration of Simeprevir can be decreased when it is combined with Tocilizumab.
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Simeprevir.
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Simeprevir.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Simeprevir.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Simeprevir.
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Simeprevir.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Simeprevir.
TramadolThe serum concentration of Tramadol can be increased when it is combined with Simeprevir.
TrandolaprilThe serum concentration of Simeprevir can be increased when it is combined with Trandolapril.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Simeprevir.
TrazodoneThe serum concentration of Trazodone can be increased when it is combined with Simeprevir.
TrazodoneThe serum concentration of Simeprevir can be decreased when it is combined with Trazodone.
TretinoinThe serum concentration of Tretinoin can be increased when it is combined with Simeprevir.
TriamcinoloneThe serum concentration of Triamcinolone can be increased when it is combined with Simeprevir.
TriamtereneThe metabolism of Triamterene can be decreased when combined with Simeprevir.
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Simeprevir.
TrifluoperazineThe serum concentration of Simeprevir can be increased when it is combined with Trifluoperazine.
TrifluoperazineThe metabolism of Trifluoperazine can be decreased when combined with Simeprevir.
TriflupromazineThe serum concentration of Simeprevir can be increased when it is combined with Triflupromazine.
TrimethadioneThe serum concentration of Trimethadione can be increased when it is combined with Simeprevir.
TrimethoprimThe serum concentration of Trimethoprim can be increased when it is combined with Simeprevir.
TrimethoprimThe serum concentration of Simeprevir can be decreased when it is combined with Trimethoprim.
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Simeprevir.
TroglitazoneThe serum concentration of Troglitazone can be increased when it is combined with Simeprevir.
TroleandomycinThe serum concentration of Troleandomycin can be increased when it is combined with Simeprevir.
UbenimexThe serum concentration of Simeprevir can be increased when it is combined with Ubenimex.
UdenafilThe serum concentration of Udenafil can be increased when it is combined with Simeprevir.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Simeprevir.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Simeprevir.
ValdecoxibThe serum concentration of Valdecoxib can be increased when it is combined with Simeprevir.
VandetanibThe serum concentration of Vandetanib can be increased when it is combined with Simeprevir.
VanoxerineThe serum concentration of Vanoxerine can be increased when it is combined with Simeprevir.
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Simeprevir.
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Simeprevir.
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Simeprevir.
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Simeprevir.
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Simeprevir.
VicrivirocThe serum concentration of Vicriviroc can be increased when it is combined with Simeprevir.
VilanterolThe serum concentration of Vilanterol can be increased when it is combined with Simeprevir.
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Simeprevir.
VildagliptinThe serum concentration of Simeprevir can be increased when it is combined with Vildagliptin.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Simeprevir.
VinblastineThe serum concentration of Simeprevir can be decreased when it is combined with Vinblastine.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Simeprevir.
VincristineThe serum concentration of Simeprevir can be decreased when it is combined with Vincristine.
VindesineThe serum concentration of Vindesine can be increased when it is combined with Simeprevir.
VinorelbineThe serum concentration of Vinorelbine can be increased when it is combined with Simeprevir.
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Simeprevir.
VoriconazoleThe serum concentration of Voriconazole can be increased when it is combined with Simeprevir.
VortioxetineThe serum concentration of Vortioxetine can be increased when it is combined with Simeprevir.
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Simeprevir.
XimelagatranThe serum concentration of Simeprevir can be increased when it is combined with Ximelagatran.
YohimbineThe serum concentration of Yohimbine can be increased when it is combined with Simeprevir.
ZafirlukastThe serum concentration of Zafirlukast can be increased when it is combined with Simeprevir.
ZalcitabineThe serum concentration of Zalcitabine can be increased when it is combined with Simeprevir.
ZaleplonThe serum concentration of Zaleplon can be increased when it is combined with Simeprevir.
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Simeprevir.
ZileutonThe serum concentration of Zileuton can be increased when it is combined with Simeprevir.
ZimelidineThe serum concentration of Simeprevir can be increased when it is combined with Zimelidine.
ZiprasidoneThe serum concentration of Ziprasidone can be increased when it is combined with Simeprevir.
ZolmitriptanThe metabolism of Zolmitriptan can be decreased when combined with Simeprevir.
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Simeprevir.
ZomepiracThe serum concentration of Zomepirac can be increased when it is combined with Simeprevir.
ZonisamideThe serum concentration of Zonisamide can be increased when it is combined with Simeprevir.
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Simeprevir.
Food Interactions
  • Simeprevir should be taken with food.

Targets

Kind
Protein
Organism
Hepatitis C virus
Pharmacological action
yes
Actions
inhibitor
General Function:
Serine-type peptidase activity
Specific Function:
Not Available
Gene Name:
Not Available
Uniprot ID:
Q91RS4
Molecular Weight:
19113.77 Da
References
  1. Raboisson P, de Kock H, Rosenquist A, Nilsson M, Salvador-Oden L, Lin TI, Roue N, Ivanov V, Wahling H, Wickstrom K, Hamelink E, Edlund M, Vrang L, Vendeville S, Van de Vreken W, McGowan D, Tahri A, Hu L, Boutton C, Lenz O, Delouvroy F, Pille G, Surleraux D, Wigerinck P, Samuelsson B, Simmen K: Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4853-8. doi: 10.1016/j.bmcl.2008.07.088. Epub 2008 Jul 24. [PubMed:18678486 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
no
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
Kind
Protein
Organism
Human
Pharmacological action
no
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da

Carriers

Kind
Protein
Organism
Human
Pharmacological action
no
Actions
binder
General Function:
Toxic substance binding
Specific Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Gene Name:
ALB
Uniprot ID:
P02768
Molecular Weight:
69365.94 Da

Transporters

Kind
Protein
Organism
Human
Pharmacological action
no
Actions
substrateinhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
Kind
Protein
Organism
Human
Pharmacological action
no
Actions
substrateinhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B1
Uniprot ID:
Q9Y6L6
Molecular Weight:
76447.99 Da
Comments
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Drug created on March 19, 2008 10:22 / Updated on September 29, 2016 02:27