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Identification
NameFosaprepitant
Accession NumberDB06717
TypeSmall Molecule
GroupsApproved
DescriptionFosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment.
Structure
Thumb
Synonyms
Fosaprepitantum
L-758,298
L-758298
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Emendinjection, powder, lyophilized, for solution115 mg/5mLintravenousMerck Sharp & Dohme Corp.2008-01-252016-02-18Us
Emendinjection, powder, lyophilized, for solution150 mg/5mLintravenousMerck Sharp & Dohme Corp.2008-01-25Not applicableUs
Emend IVpowder for solution115 mgintravenousMerck Canada Inc2009-04-302010-10-28Canada
Emend IVpowder for solution150 mgintravenousMerck Canada Inc2011-04-04Not applicableCanada
Fosaprepitantpowder for solution150 mgintravenousApotex IncNot applicableNot applicableCanada
IvemendPowder for solution for infusion150 mgIntravenous useMerck Sharp & Dohme Ltd2008-01-11Not applicableEu
IvemendPowder for solution for infusion150 mgIntravenous useMerck Sharp & Dohme Ltd2008-01-11Not applicableEu
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Fosaprepitant dimeglumine
265121-04-8
Thumb
  • InChI Key: VRQHBYGYXDWZDL-OOZCZQCLSA-N
  • Monoisotopic Mass: 1004.337863721
  • Average Mass: 1004.8337
DBSALT000089
Categories
UNII6L8OF9XRDC
CAS number172673-20-0
WeightAverage: 614.4066
Monoisotopic: 614.116518403
Chemical FormulaC23H22F7N4O6P
InChI KeyInChIKey=BARDROPHSZEBKC-OITMNORJSA-N
InChI
InChI=1S/C23H22F7N4O6P/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)40-20-19(13-2-4-17(24)5-3-13)33(6-7-39-20)11-18-31-21(35)34(32-18)41(36,37)38/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H,31,32,35)(H2,36,37,38)/t12-,19+,20-/m1/s1
IUPAC Name
(3-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-5-oxo-2,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid
SMILES
C[C@@H](O[[email protected]]1OCCN(CC2=NC(=O)N(N2)P(O)(O)=O)[[email protected]]1C1=CC=C(F)C=C1)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenylmorpholines. These are aromatic compounds containing a morpholine ring and a benzene ring linked to each other through a CC or a CN bond.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassOxazinanes
Sub ClassMorpholines
Direct ParentPhenylmorpholines
Alternative Parents
Substituents
  • Phenylmorpholine
  • Aralkylamine
  • Halobenzene
  • Fluorobenzene
  • Benzenoid
  • Monocyclic benzene moiety
  • Aryl halide
  • Aryl fluoride
  • Heteroaromatic compound
  • 1,2,4-triazole
  • Azole
  • Tertiary aliphatic amine
  • Tertiary amine
  • Oxacycle
  • Azacycle
  • Acetal
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organofluoride
  • Organohalogen compound
  • Amine
  • Alkyl halide
  • Alkyl fluoride
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationFor the prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy.
PharmacodynamicsFosaprepitant is a prodrug of Aprepitant. Once biologically activated, the drug acts as a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. Aprepitant has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors, the targets of existing therapies for chemotherapy-induced nausea and vomiting (CI NV).
Mechanism of actionAprepitant has been shown in animal models to inhibit emesis induced by cytotoxic chemotherapeutic agents, such as cisplatin, via central actions. Animal and human Positron Emission Tomography (PET) studies with Aprepitant have shown that it crosses the blood brain barrier and occupies brain NK1 receptors. Animal and human studies show that Aprepitant augments the antiemetic activity of the 5-HT3-receptor antagonist ondansetron and the corticosteroid ethasone and inhibits both the acute and delayed phases of cisplatin induced emesis. In summary, the active form of fosaprepitant is as an NK1 antagonist which is because it blocks signals given off by NK1 receptors. This therefore decreases the likelihood of vomiting in patients experiencing.
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein binding95% +
Metabolism

Aprepitant is metabolized primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19. Seven metabolites of aprepitant, which are only weakly active, have been identified in human plasma.

Route of eliminationAprepitant is eliminated primarily by metabolism; aprepitant is not renally excreted. Aprepitant is excreted in the milk of rats. It is not known whether this drug is excreted in human milk.
Half life9-13 hours
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption-0.5225
Blood Brain Barrier-0.81
Caco-2 permeable-0.6534
P-glycoprotein substrateSubstrate0.8255
P-glycoprotein inhibitor INon-inhibitor0.6532
P-glycoprotein inhibitor IINon-inhibitor0.986
Renal organic cation transporterNon-inhibitor0.8583
CYP450 2C9 substrateNon-substrate0.7018
CYP450 2D6 substrateNon-substrate0.8588
CYP450 3A4 substrateSubstrate0.546
CYP450 1A2 substrateNon-inhibitor0.7539
CYP450 2C9 inhibitorNon-inhibitor0.644
CYP450 2D6 inhibitorNon-inhibitor0.8521
CYP450 2C19 inhibitorNon-inhibitor0.6705
CYP450 3A4 inhibitorInhibitor0.6258
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.5
Ames testNon AMES toxic0.5349
CarcinogenicityNon-carcinogens0.7701
BiodegradationNot ready biodegradable0.9899
Rat acute toxicity2.6064 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.5
hERG inhibition (predictor II)Inhibitor0.6528
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
Injection, powder, lyophilized, for solutionintravenous115 mg/5mL
Injection, powder, lyophilized, for solutionintravenous150 mg/5mL
Powder for solutionintravenous115 mg
Powder for solutionintravenous150 mg
Powder for solution for infusionIntravenous use150 mg
PricesNot Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5691336 No1999-03-042019-03-04Us
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.00632 mg/mLALOGPS
logP2.89ALOGPS
logP2.4ChemAxon
logS-5ALOGPS
pKa (Strongest Acidic)1.02ChemAxon
pKa (Strongest Basic)5.69ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count9ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area123.93 Å2ChemAxon
Rotatable Bond Count9ChemAxon
Refractivity138.63 m3·mol-1ChemAxon
Polarizability49.92 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

Navin Ganesh Bhatt, Nikhil Rasiklal Trivedi, Mahesh Khedekar, Sukumar Sinha, Mubeen Ahmed Khan, Ramjilal Yadav, “FOSAPREPITANT DIMEGLUMINE INTERMEDIATE, NEUTRAL FOSAPREPITANT, AND AMORPHOUS FOSAPREPITANT DIMEGLUMINE AND PROCESSES FOR THEIR PREPARATIONS.” U.S. Patent US20110130366, issued June 02, 2011.

US20110130366
General ReferencesNot Available
External Links
ATC CodesNot Available
AHFS Codes
  • 56:22.92
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
Interactions
Drug Interactions
Drug
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be increased when it is combined with Fosaprepitant.
AbirateroneThe serum concentration of Abiraterone can be increased when it is combined with Fosaprepitant.
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Fosaprepitant.
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Fosaprepitant.
AdinazolamThe serum concentration of Adinazolam can be increased when it is combined with Fosaprepitant.
AlbendazoleThe serum concentration of Albendazole can be increased when it is combined with Fosaprepitant.
AlclometasoneThe serum concentration of Alclometasone can be increased when it is combined with Fosaprepitant.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Fosaprepitant.
AlfentanilThe serum concentration of Alfentanil can be increased when it is combined with Fosaprepitant.
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Fosaprepitant.
AliskirenThe serum concentration of Aliskiren can be increased when it is combined with Fosaprepitant.
AllylestrenolThe serum concentration of Allylestrenol can be increased when it is combined with Fosaprepitant.
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Fosaprepitant.
AlogliptinThe serum concentration of Alogliptin can be increased when it is combined with Fosaprepitant.
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Fosaprepitant.
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Fosaprepitant.
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Fosaprepitant.
AmbroxolThe serum concentration of Ambroxol can be increased when it is combined with Fosaprepitant.
AmcinonideThe serum concentration of Amcinonide can be increased when it is combined with Fosaprepitant.
AminophenazoneThe serum concentration of Aminophenazone can be increased when it is combined with Fosaprepitant.
AminophyllineThe serum concentration of Aminophylline can be increased when it is combined with Fosaprepitant.
AmiodaroneThe serum concentration of Amiodarone can be increased when it is combined with Fosaprepitant.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Fosaprepitant.
AmlodipineThe serum concentration of Amlodipine can be increased when it is combined with Fosaprepitant.
AmprenavirThe serum concentration of Amprenavir can be increased when it is combined with Fosaprepitant.
AntipyrineThe serum concentration of Antipyrine can be increased when it is combined with Fosaprepitant.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Fosaprepitant.
ApremilastThe serum concentration of Apremilast can be increased when it is combined with Fosaprepitant.
AprepitantThe serum concentration of Aprepitant can be increased when it is combined with Fosaprepitant.
ArgatrobanThe serum concentration of Argatroban can be increased when it is combined with Fosaprepitant.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Fosaprepitant.
ArtemetherThe serum concentration of Artemether can be increased when it is combined with Fosaprepitant.
AsenapineThe serum concentration of Asenapine can be increased when it is combined with Fosaprepitant.
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Fosaprepitant.
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Fosaprepitant.
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Fosaprepitant.
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Fosaprepitant.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Fosaprepitant.
AzelastineThe serum concentration of Azelastine can be increased when it is combined with Fosaprepitant.
AzithromycinThe serum concentration of Azithromycin can be increased when it is combined with Fosaprepitant.
BanoxantroneThe serum concentration of Banoxantrone can be increased when it is combined with Fosaprepitant.
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be increased when it is combined with Fosaprepitant.
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Fosaprepitant.
BenzphetamineThe serum concentration of Benzphetamine can be increased when it is combined with Fosaprepitant.
Benzyl alcoholThe serum concentration of Benzyl alcohol can be increased when it is combined with Fosaprepitant.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Fosaprepitant.
BexaroteneThe serum concentration of Bexarotene can be increased when it is combined with Fosaprepitant.
BezafibrateThe serum concentration of Bezafibrate can be increased when it is combined with Fosaprepitant.
BicalutamideThe serum concentration of Bicalutamide can be increased when it is combined with Fosaprepitant.
BisoprololThe serum concentration of Bisoprolol can be increased when it is combined with Fosaprepitant.
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Fosaprepitant.
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Fosaprepitant.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Fosaprepitant.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Fosaprepitant.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Fosaprepitant.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Fosaprepitant.
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Fosaprepitant.
BromazepamThe serum concentration of Bromazepam can be increased when it is combined with Fosaprepitant.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Fosaprepitant.
BrompheniramineThe serum concentration of Brompheniramine can be increased when it is combined with Fosaprepitant.
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Fosaprepitant.
BupivacaineThe serum concentration of Bupivacaine can be increased when it is combined with Fosaprepitant.
BuprenorphineThe serum concentration of Buprenorphine can be increased when it is combined with Fosaprepitant.
BupropionThe serum concentration of Bupropion can be increased when it is combined with Fosaprepitant.
BuspironeThe serum concentration of Buspirone can be increased when it is combined with Fosaprepitant.
BusulfanThe serum concentration of Busulfan can be increased when it is combined with Fosaprepitant.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Fosaprepitant.
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Fosaprepitant.
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Fosaprepitant.
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Fosaprepitant.
CalcitriolThe serum concentration of Calcitriol can be increased when it is combined with Fosaprepitant.
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Fosaprepitant.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Fosaprepitant.
CarbinoxamineThe serum concentration of Carbinoxamine can be increased when it is combined with Fosaprepitant.
CariprazineThe serum concentration of Cariprazine can be increased when it is combined with Fosaprepitant.
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Fosaprepitant.
CelecoxibThe serum concentration of Celecoxib can be increased when it is combined with Fosaprepitant.
CeliprololThe serum concentration of Celiprolol can be increased when it is combined with Fosaprepitant.
CephalexinThe serum concentration of Cephalexin can be increased when it is combined with Fosaprepitant.
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Fosaprepitant.
CevimelineThe serum concentration of Cevimeline can be increased when it is combined with Fosaprepitant.
Chenodeoxycholic acidThe serum concentration of Chenodeoxycholic acid can be increased when it is combined with Fosaprepitant.
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be increased when it is combined with Fosaprepitant.
ChloroquineThe serum concentration of Chloroquine can be increased when it is combined with Fosaprepitant.
ChlorphenamineThe serum concentration of Chlorphenamine can be increased when it is combined with Fosaprepitant.
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Fosaprepitant.
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be increased when it is combined with Fosaprepitant.
CholecalciferolThe serum concentration of Cholecalciferol can be increased when it is combined with Fosaprepitant.
CiclesonideThe serum concentration of Ciclesonide can be increased when it is combined with Fosaprepitant.
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Fosaprepitant.
CinacalcetThe serum concentration of Cinacalcet can be increased when it is combined with Fosaprepitant.
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Fosaprepitant.
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Fosaprepitant.
ClarithromycinThe serum concentration of Clarithromycin can be increased when it is combined with Fosaprepitant.
ClindamycinThe serum concentration of Clindamycin can be increased when it is combined with Fosaprepitant.
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Fosaprepitant.
Clobetasol propionateThe serum concentration of Clobetasol propionate can be increased when it is combined with Fosaprepitant.
ClocortoloneThe serum concentration of Clocortolone can be increased when it is combined with Fosaprepitant.
ClofazimineThe serum concentration of Clofazimine can be increased when it is combined with Fosaprepitant.
ClofibrateThe serum concentration of Clofibrate can be increased when it is combined with Fosaprepitant.
clomethiazoleThe serum concentration of clomethiazole can be increased when it is combined with Fosaprepitant.
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Fosaprepitant.
ClonazepamThe serum concentration of Clonazepam can be increased when it is combined with Fosaprepitant.
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Fosaprepitant.
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Fosaprepitant.
ClorazepateThe serum concentration of Clorazepate can be increased when it is combined with Fosaprepitant.
ClotiazepamThe serum concentration of Clotiazepam can be increased when it is combined with Fosaprepitant.
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Fosaprepitant.
CocaineThe serum concentration of Cocaine can be increased when it is combined with Fosaprepitant.
CodeineThe serum concentration of Codeine can be increased when it is combined with Fosaprepitant.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Fosaprepitant.
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Fosaprepitant.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Fosaprepitant.
Cortisone acetateThe serum concentration of Cortisone acetate can be increased when it is combined with Fosaprepitant.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Fosaprepitant.
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Fosaprepitant.
CyclophosphamideThe serum concentration of Cyclophosphamide can be increased when it is combined with Fosaprepitant.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Fosaprepitant.
CytarabineThe serum concentration of Cytarabine can be increased when it is combined with Fosaprepitant.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Fosaprepitant.
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Fosaprepitant.
DantroleneThe serum concentration of Dantrolene can be increased when it is combined with Fosaprepitant.
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Fosaprepitant.
DapsoneThe serum concentration of Dapsone can be increased when it is combined with Fosaprepitant.
DarifenacinThe serum concentration of Darifenacin can be increased when it is combined with Fosaprepitant.
DarunavirThe serum concentration of Darunavir can be increased when it is combined with Fosaprepitant.
DasabuvirThe serum concentration of Dasabuvir can be increased when it is combined with Fosaprepitant.
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Fosaprepitant.
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Fosaprepitant.
DehydroepiandrosteroneThe serum concentration of Dehydroepiandrosterone can be increased when it is combined with Fosaprepitant.
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be increased when it is combined with Fosaprepitant.
DelavirdineThe serum concentration of Delavirdine can be increased when it is combined with Fosaprepitant.
DesoximetasoneThe serum concentration of Desoximetasone can be increased when it is combined with Fosaprepitant.
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be increased when it is combined with Fosaprepitant.
DesvenlafaxineThe serum concentration of Desvenlafaxine can be increased when it is combined with Fosaprepitant.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Fosaprepitant.
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Fosaprepitant.
DextromethorphanThe serum concentration of Dextromethorphan can be increased when it is combined with Fosaprepitant.
DextropropoxypheneThe serum concentration of Dextropropoxyphene can be increased when it is combined with Fosaprepitant.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Fosaprepitant.
DiclofenacThe serum concentration of Diclofenac can be increased when it is combined with Fosaprepitant.
DiflorasoneThe serum concentration of Diflorasone can be increased when it is combined with Fosaprepitant.
DifluocortoloneThe serum concentration of Difluocortolone can be increased when it is combined with Fosaprepitant.
DifluprednateThe serum concentration of Difluprednate can be increased when it is combined with Fosaprepitant.
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Fosaprepitant.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Fosaprepitant.
DihydrocodeineThe serum concentration of Dihydrocodeine can be increased when it is combined with Fosaprepitant.
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Fosaprepitant.
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Fosaprepitant.
DisopyramideThe serum concentration of Disopyramide can be increased when it is combined with Fosaprepitant.
DisulfiramThe serum concentration of Disulfiram can be increased when it is combined with Fosaprepitant.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Fosaprepitant.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Fosaprepitant.
DolasetronThe serum concentration of Dolasetron can be increased when it is combined with Fosaprepitant.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Fosaprepitant.
DonepezilThe serum concentration of Donepezil can be increased when it is combined with Fosaprepitant.
DorzolamideThe serum concentration of Dorzolamide can be increased when it is combined with Fosaprepitant.
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Fosaprepitant.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Fosaprepitant.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Fosaprepitant.
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Fosaprepitant.
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Fosaprepitant.
EfavirenzThe serum concentration of Efavirenz can be increased when it is combined with Fosaprepitant.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Fosaprepitant.
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Fosaprepitant.
ElvitegravirThe serum concentration of Elvitegravir can be increased when it is combined with Fosaprepitant.
EnalaprilThe serum concentration of Enalapril can be increased when it is combined with Fosaprepitant.
EnzalutamideThe serum concentration of Enzalutamide can be increased when it is combined with Fosaprepitant.
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Fosaprepitant.
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Fosaprepitant.
EquileninThe serum concentration of Equilenin can be increased when it is combined with Fosaprepitant.
EquilinThe serum concentration of Equilin can be increased when it is combined with Fosaprepitant.
ErgocalciferolThe serum concentration of Ergocalciferol can be increased when it is combined with Fosaprepitant.
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Fosaprepitant.
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Fosaprepitant.
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Fosaprepitant.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Fosaprepitant.
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Fosaprepitant.
EscitalopramThe serum concentration of Escitalopram can be increased when it is combined with Fosaprepitant.
EsomeprazoleThe serum concentration of Esomeprazole can be increased when it is combined with Fosaprepitant.
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Fosaprepitant.
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Fosaprepitant.
Estradiol valerate/DienogestThe serum concentration of Estradiol valerate/Dienogest can be increased when it is combined with Fosaprepitant.
EstramustineThe serum concentration of Estramustine can be increased when it is combined with Fosaprepitant.
EstroneThe serum concentration of Estrone can be increased when it is combined with Fosaprepitant.
Estrone sulfateThe serum concentration of Estrone sulfate can be increased when it is combined with Fosaprepitant.
EszopicloneThe serum concentration of Eszopiclone can be increased when it is combined with Fosaprepitant.
EthanolThe serum concentration of Ethanol can be increased when it is combined with Fosaprepitant.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Fosaprepitant.
EthosuximideThe serum concentration of Ethosuximide can be increased when it is combined with Fosaprepitant.
EthylmorphineThe serum concentration of Ethylmorphine can be increased when it is combined with Fosaprepitant.
EtonogestrelThe serum concentration of Etonogestrel can be increased when it is combined with Fosaprepitant.
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Fosaprepitant.
EtoricoxibThe serum concentration of Etoricoxib can be increased when it is combined with Fosaprepitant.
EtravirineThe serum concentration of Etravirine can be increased when it is combined with Fosaprepitant.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Fosaprepitant.
ExemestaneThe serum concentration of Exemestane can be increased when it is combined with Fosaprepitant.
FamciclovirThe serum concentration of Famciclovir can be increased when it is combined with Fosaprepitant.
FelbamateThe serum concentration of Felbamate can be increased when it is combined with Fosaprepitant.
FelodipineThe serum concentration of Felodipine can be increased when it is combined with Fosaprepitant.
FenofibrateThe serum concentration of Fenofibrate can be increased when it is combined with Fosaprepitant.
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Fosaprepitant.
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Fosaprepitant.
FinasterideThe serum concentration of Finasteride can be increased when it is combined with Fosaprepitant.
FingolimodThe serum concentration of Fingolimod can be increased when it is combined with Fosaprepitant.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Fosaprepitant.
FludrocortisoneThe serum concentration of Fludrocortisone can be increased when it is combined with Fosaprepitant.
FlumethasoneThe serum concentration of Flumethasone can be increased when it is combined with Fosaprepitant.
FlunisolideThe serum concentration of Flunisolide can be increased when it is combined with Fosaprepitant.
FlunitrazepamThe serum concentration of Flunitrazepam can be increased when it is combined with Fosaprepitant.
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be increased when it is combined with Fosaprepitant.
FluocinonideThe serum concentration of Fluocinonide can be increased when it is combined with Fosaprepitant.
FluocortoloneThe serum concentration of Fluocortolone can be increased when it is combined with Fosaprepitant.
FluorometholoneThe serum concentration of Fluorometholone can be increased when it is combined with Fosaprepitant.
FluoxetineThe serum concentration of Fluoxetine can be increased when it is combined with Fosaprepitant.
FluprednideneThe serum concentration of Fluprednidene can be increased when it is combined with Fosaprepitant.
FluprednisoloneThe serum concentration of Fluprednisolone can be increased when it is combined with Fosaprepitant.
FlurandrenolideThe serum concentration of Flurandrenolide can be increased when it is combined with Fosaprepitant.
FlurazepamThe serum concentration of Flurazepam can be increased when it is combined with Fosaprepitant.
FlutamideThe serum concentration of Flutamide can be increased when it is combined with Fosaprepitant.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Fosaprepitant.
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Fosaprepitant.
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Fosaprepitant.
FosamprenavirThe serum concentration of Fosamprenavir can be increased when it is combined with Fosaprepitant.
FulvestrantThe serum concentration of Fulvestrant can be increased when it is combined with Fosaprepitant.
GalantamineThe serum concentration of Galantamine can be increased when it is combined with Fosaprepitant.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Fosaprepitant.
GemfibrozilThe serum concentration of Gemfibrozil can be increased when it is combined with Fosaprepitant.
GlipizideThe serum concentration of Glipizide can be increased when it is combined with Fosaprepitant.
GlyburideThe serum concentration of Glyburide can be increased when it is combined with Fosaprepitant.
GranisetronThe serum concentration of Granisetron can be increased when it is combined with Fosaprepitant.
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Fosaprepitant.
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Fosaprepitant.
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Fosaprepitant.
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Fosaprepitant.
HalothaneThe serum concentration of Halothane can be increased when it is combined with Fosaprepitant.
HexobarbitalThe serum concentration of Hexobarbital can be increased when it is combined with Fosaprepitant.
Histamine PhosphateThe serum concentration of Histamine Phosphate can be increased when it is combined with Fosaprepitant.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Fosaprepitant.
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Fosaprepitant.
HydromorphoneThe serum concentration of Hydromorphone can be increased when it is combined with Fosaprepitant.
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be increased when it is combined with Fosaprepitant.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Fosaprepitant.
IfosfamideThe serum concentration of Ifosfamide can be increased when it is combined with Fosaprepitant.
IloperidoneThe serum concentration of Iloperidone can be increased when it is combined with Fosaprepitant.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Fosaprepitant.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Fosaprepitant.
ImiquimodThe serum concentration of Imiquimod can be increased when it is combined with Fosaprepitant.
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Fosaprepitant.
IndapamideThe serum concentration of Indapamide can be increased when it is combined with Fosaprepitant.
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Fosaprepitant.
Ipratropium bromideThe serum concentration of Ipratropium bromide can be increased when it is combined with Fosaprepitant.
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Fosaprepitant.
IsavuconazoniumThe serum concentration of Isavuconazonium can be increased when it is combined with Fosaprepitant.
Isosorbide DinitrateThe serum concentration of Isosorbide Dinitrate can be increased when it is combined with Fosaprepitant.
Isosorbide MononitrateThe serum concentration of Isosorbide Mononitrate can be increased when it is combined with Fosaprepitant.
IsradipineThe serum concentration of Isradipine can be increased when it is combined with Fosaprepitant.
ItraconazoleThe serum concentration of Itraconazole can be increased when it is combined with Fosaprepitant.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Fosaprepitant.
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Fosaprepitant.
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Fosaprepitant.
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Fosaprepitant.
IxazomibThe serum concentration of Ixazomib can be increased when it is combined with Fosaprepitant.
KetamineThe serum concentration of Ketamine can be increased when it is combined with Fosaprepitant.
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Fosaprepitant.
KetobemidoneThe serum concentration of Ketobemidone can be increased when it is combined with Fosaprepitant.
KetoconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Fosaprepitant.
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Fosaprepitant.
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Fosaprepitant.
LaquinimodThe serum concentration of Laquinimod can be increased when it is combined with Fosaprepitant.
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Fosaprepitant.
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Fosaprepitant.
LetrozoleThe serum concentration of Letrozole can be increased when it is combined with Fosaprepitant.
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Fosaprepitant.
LevocetirizineThe serum concentration of Levocetirizine can be increased when it is combined with Fosaprepitant.
Levomethadyl AcetateThe serum concentration of Levomethadyl Acetate can be increased when it is combined with Fosaprepitant.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Fosaprepitant.
LevonorgestrelThe serum concentration of Levonorgestrel can be increased when it is combined with Fosaprepitant.
LevothyroxineThe serum concentration of Levothyroxine can be increased when it is combined with Fosaprepitant.
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Fosaprepitant.
LisurideThe serum concentration of Lisuride can be increased when it is combined with Fosaprepitant.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Fosaprepitant.
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Fosaprepitant.
LopinavirThe serum concentration of Lopinavir can be increased when it is combined with Fosaprepitant.
LoratadineThe serum concentration of Loratadine can be increased when it is combined with Fosaprepitant.
LorcaserinThe serum concentration of Lorcaserin can be increased when it is combined with Fosaprepitant.
LosartanThe serum concentration of Losartan can be increased when it is combined with Fosaprepitant.
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Fosaprepitant.
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Fosaprepitant.
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Fosaprepitant.
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Fosaprepitant.
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Fosaprepitant.
MebendazoleThe serum concentration of Mebendazole can be increased when it is combined with Fosaprepitant.
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Fosaprepitant.
MedrysoneThe serum concentration of Medrysone can be increased when it is combined with Fosaprepitant.
MefloquineThe serum concentration of Mefloquine can be increased when it is combined with Fosaprepitant.
MelengestrolThe serum concentration of Melengestrol can be increased when it is combined with Fosaprepitant.
MeloxicamThe serum concentration of Meloxicam can be increased when it is combined with Fosaprepitant.
MethadoneThe serum concentration of Methadone can be increased when it is combined with Fosaprepitant.
MethaqualoneThe serum concentration of Methaqualone can be increased when it is combined with Fosaprepitant.
MethoxsalenThe serum concentration of Methoxsalen can be increased when it is combined with Fosaprepitant.
MethoxyfluraneThe serum concentration of Methoxyflurane can be increased when it is combined with Fosaprepitant.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Fosaprepitant.
MethyltestosteroneThe serum concentration of Methyltestosterone can be increased when it is combined with Fosaprepitant.
MetronidazoleThe serum concentration of Metronidazole can be increased when it is combined with Fosaprepitant.
MexiletineThe serum concentration of Mexiletine can be increased when it is combined with Fosaprepitant.
MianserinThe serum concentration of Mianserin can be increased when it is combined with Fosaprepitant.
MibefradilThe serum concentration of Mibefradil can be increased when it is combined with Fosaprepitant.
MiconazoleThe serum concentration of Miconazole can be increased when it is combined with Fosaprepitant.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Fosaprepitant.
MifepristoneThe serum concentration of Mifepristone can be increased when it is combined with Fosaprepitant.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Fosaprepitant.
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Fosaprepitant.
ModafinilThe serum concentration of Modafinil can be increased when it is combined with Fosaprepitant.
MometasoneThe serum concentration of Mometasone can be increased when it is combined with Fosaprepitant.
MontelukastThe serum concentration of Montelukast can be increased when it is combined with Fosaprepitant.
MorphineThe serum concentration of Morphine can be increased when it is combined with Fosaprepitant.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Fosaprepitant.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Fosaprepitant.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Fosaprepitant.
NateglinideThe serum concentration of Nateglinide can be increased when it is combined with Fosaprepitant.
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Fosaprepitant.
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Fosaprepitant.
NevirapineThe serum concentration of Nevirapine can be increased when it is combined with Fosaprepitant.
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Fosaprepitant.
NicotineThe serum concentration of Nicotine can be increased when it is combined with Fosaprepitant.
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Fosaprepitant.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Fosaprepitant.
NilvadipineThe serum concentration of Nilvadipine can be increased when it is combined with Fosaprepitant.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Fosaprepitant.
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Fosaprepitant.
NitrazepamThe serum concentration of Nitrazepam can be increased when it is combined with Fosaprepitant.
NitrendipineThe serum concentration of Nitrendipine can be increased when it is combined with Fosaprepitant.
NorethisteroneThe serum concentration of Norethisterone can be increased when it is combined with Fosaprepitant.
NorgestrelThe serum concentration of Norgestrel can be increased when it is combined with Fosaprepitant.
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Fosaprepitant.
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Fosaprepitant.
OlopatadineThe serum concentration of Olopatadine can be increased when it is combined with Fosaprepitant.
OmeprazoleThe serum concentration of Omeprazole can be increased when it is combined with Fosaprepitant.
OndansetronThe serum concentration of Ondansetron can be increased when it is combined with Fosaprepitant.
OrphenadrineThe serum concentration of Orphenadrine can be increased when it is combined with Fosaprepitant.
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Fosaprepitant.
OxazepamThe serum concentration of Oxazepam can be increased when it is combined with Fosaprepitant.
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Fosaprepitant.
OxycodoneThe serum concentration of Oxycodone can be increased when it is combined with Fosaprepitant.
OxymorphoneThe serum concentration of Oxymorphone can be increased when it is combined with Fosaprepitant.
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Fosaprepitant.
PalbociclibThe serum concentration of Palbociclib can be increased when it is combined with Fosaprepitant.
PalonosetronThe serum concentration of Palonosetron can be increased when it is combined with Fosaprepitant.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Fosaprepitant.
PantoprazoleThe serum concentration of Pantoprazole can be increased when it is combined with Fosaprepitant.
ParamethadioneThe serum concentration of Paramethadione can be increased when it is combined with Fosaprepitant.
ParamethasoneThe serum concentration of Paramethasone can be increased when it is combined with Fosaprepitant.
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Fosaprepitant.
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Fosaprepitant.
ParitaprevirThe serum concentration of Paritaprevir can be increased when it is combined with Fosaprepitant.
ParoxetineThe serum concentration of the active metabolites of Fosaprepitant can be reduced when Fosaprepitant is used in combination with Paroxetine resulting in a loss in efficacy.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Fosaprepitant.
PentamidineThe serum concentration of Pentamidine can be increased when it is combined with Fosaprepitant.
PerampanelThe serum concentration of Perampanel can be increased when it is combined with Fosaprepitant.
PergolideThe serum concentration of Pergolide can be increased when it is combined with Fosaprepitant.
PerhexilineThe serum concentration of Perhexiline can be increased when it is combined with Fosaprepitant.
PermethrinThe serum concentration of Permethrin can be increased when it is combined with Fosaprepitant.
PerphenazineThe serum concentration of Perphenazine can be increased when it is combined with Fosaprepitant.
PethidineThe serum concentration of Pethidine can be increased when it is combined with Fosaprepitant.
PhenacetinThe serum concentration of Phenacetin can be increased when it is combined with Fosaprepitant.
PhenoxybenzamineThe serum concentration of Phenoxybenzamine can be increased when it is combined with Fosaprepitant.
PhenprocoumonThe serum concentration of Phenprocoumon can be increased when it is combined with Fosaprepitant.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Fosaprepitant.
PilocarpineThe serum concentration of Pilocarpine can be increased when it is combined with Fosaprepitant.
PimecrolimusThe serum concentration of Pimecrolimus can be increased when it is combined with Fosaprepitant.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Fosaprepitant.
PinacidilThe serum concentration of Pinacidil can be increased when it is combined with Fosaprepitant.
PioglitazoneThe serum concentration of Pioglitazone can be increased when it is combined with Fosaprepitant.
PipotiazineThe serum concentration of Pipotiazine can be increased when it is combined with Fosaprepitant.
PodofiloxThe serum concentration of Podofilox can be increased when it is combined with Fosaprepitant.
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Fosaprepitant.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Fosaprepitant.
PosaconazoleThe serum concentration of Posaconazole can be increased when it is combined with Fosaprepitant.
PrasugrelThe serum concentration of Prasugrel can be increased when it is combined with Fosaprepitant.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Fosaprepitant.
PrazepamThe serum concentration of Prazepam can be increased when it is combined with Fosaprepitant.
PraziquantelThe serum concentration of Praziquantel can be increased when it is combined with Fosaprepitant.
PrednicarbateThe serum concentration of Prednicarbate can be increased when it is combined with Fosaprepitant.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Fosaprepitant.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Fosaprepitant.
PregnenoloneThe serum concentration of Pregnenolone can be increased when it is combined with Fosaprepitant.
PrimaquineThe serum concentration of Primaquine can be increased when it is combined with Fosaprepitant.
ProchlorperazineThe serum concentration of Prochlorperazine can be increased when it is combined with Fosaprepitant.
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Fosaprepitant.
ProguanilThe serum concentration of Proguanil can be increased when it is combined with Fosaprepitant.
PromazineThe serum concentration of Promazine can be increased when it is combined with Fosaprepitant.
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Fosaprepitant.
PropofolThe serum concentration of Propofol can be increased when it is combined with Fosaprepitant.
PropranololThe serum concentration of Propranolol can be increased when it is combined with Fosaprepitant.
PyrazinamideThe serum concentration of Pyrazinamide can be increased when it is combined with Fosaprepitant.
QuazepamThe serum concentration of Quazepam can be increased when it is combined with Fosaprepitant.
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Fosaprepitant.
QuinacrineThe serum concentration of Quinacrine can be increased when it is combined with Fosaprepitant.
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Fosaprepitant.
QuinineThe serum concentration of Quinine can be increased when it is combined with Fosaprepitant.
RabeprazoleThe serum concentration of Rabeprazole can be increased when it is combined with Fosaprepitant.
RaloxifeneThe serum concentration of Raloxifene can be increased when it is combined with Fosaprepitant.
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Fosaprepitant.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Fosaprepitant.
ReboxetineThe serum concentration of Reboxetine can be increased when it is combined with Fosaprepitant.
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Fosaprepitant.
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Fosaprepitant.
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Fosaprepitant.
RifabutinThe serum concentration of Rifabutin can be increased when it is combined with Fosaprepitant.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Fosaprepitant.
RifampicinThe serum concentration of Fosaprepitant can be decreased when it is combined with Rifampicin.
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Fosaprepitant.
RimexoloneThe serum concentration of Rimexolone can be increased when it is combined with Fosaprepitant.
RimonabantThe serum concentration of Rimonabant can be increased when it is combined with Fosaprepitant.
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Fosaprepitant.
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Fosaprepitant.
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Fosaprepitant.
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Fosaprepitant.
RofecoxibThe serum concentration of Rofecoxib can be increased when it is combined with Fosaprepitant.
RolapitantThe serum concentration of Rolapitant can be increased when it is combined with Fosaprepitant.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Fosaprepitant.
RopiniroleThe serum concentration of Ropinirole can be increased when it is combined with Fosaprepitant.
RopivacaineThe serum concentration of Ropivacaine can be increased when it is combined with Fosaprepitant.
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Fosaprepitant.
RotigotineThe serum concentration of Rotigotine can be increased when it is combined with Fosaprepitant.
RoxithromycinThe serum concentration of Roxithromycin can be increased when it is combined with Fosaprepitant.
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Fosaprepitant.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Fosaprepitant.
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Fosaprepitant.
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Fosaprepitant.
SelegilineThe serum concentration of Selegiline can be increased when it is combined with Fosaprepitant.
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Fosaprepitant.
SeratrodastThe serum concentration of Seratrodast can be increased when it is combined with Fosaprepitant.
SertindoleThe serum concentration of Sertindole can be increased when it is combined with Fosaprepitant.
SertralineThe serum concentration of Sertraline can be increased when it is combined with Fosaprepitant.
SevofluraneThe serum concentration of Sevoflurane can be increased when it is combined with Fosaprepitant.
SibutramineThe serum concentration of Sibutramine can be increased when it is combined with Fosaprepitant.
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Fosaprepitant.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Fosaprepitant.
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Fosaprepitant.
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Fosaprepitant.
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Fosaprepitant.
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Fosaprepitant.
SolifenacinThe serum concentration of Solifenacin can be increased when it is combined with Fosaprepitant.
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Fosaprepitant.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Fosaprepitant.
SpiramycinThe serum concentration of Spiramycin can be increased when it is combined with Fosaprepitant.
SufentanilThe serum concentration of Sufentanil can be increased when it is combined with Fosaprepitant.
SulfadiazineThe serum concentration of Sulfadiazine can be increased when it is combined with Fosaprepitant.
SulfamethoxazoleThe serum concentration of Sulfamethoxazole can be increased when it is combined with Fosaprepitant.
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be increased when it is combined with Fosaprepitant.
SunitinibThe serum concentration of Sunitinib can be increased when it is combined with Fosaprepitant.
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be increased when it is combined with Fosaprepitant.
Synthetic Conjugated Estrogens, BThe serum concentration of Synthetic Conjugated Estrogens, B can be increased when it is combined with Fosaprepitant.
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Fosaprepitant.
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Fosaprepitant.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Fosaprepitant.
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Fosaprepitant.
TasosartanThe serum concentration of Tasosartan can be increased when it is combined with Fosaprepitant.
Taurochenodeoxycholic acidThe serum concentration of Taurochenodeoxycholic acid can be increased when it is combined with Fosaprepitant.
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Fosaprepitant.
TelithromycinThe serum concentration of Telithromycin can be increased when it is combined with Fosaprepitant.
TemazepamThe serum concentration of Temazepam can be increased when it is combined with Fosaprepitant.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Fosaprepitant.
TeniposideThe serum concentration of Teniposide can be increased when it is combined with Fosaprepitant.
TerbinafineThe serum concentration of Terbinafine can be increased when it is combined with Fosaprepitant.
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Fosaprepitant.
TesmilifeneThe serum concentration of Tesmilifene can be increased when it is combined with Fosaprepitant.
TestosteroneThe serum concentration of Testosterone can be increased when it is combined with Fosaprepitant.
TetracyclineThe serum concentration of Tetracycline can be increased when it is combined with Fosaprepitant.
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Fosaprepitant.
ThiotepaThe serum concentration of Thiotepa can be increased when it is combined with Fosaprepitant.
TiagabineThe serum concentration of Tiagabine can be increased when it is combined with Fosaprepitant.
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Fosaprepitant.
TiclopidineThe serum concentration of Ticlopidine can be increased when it is combined with Fosaprepitant.
TinidazoleThe serum concentration of Tinidazole can be increased when it is combined with Fosaprepitant.
TiotropiumThe serum concentration of Tiotropium can be increased when it is combined with Fosaprepitant.
TipranavirThe serum concentration of Tipranavir can be increased when it is combined with Fosaprepitant.
TixocortolThe serum concentration of Tixocortol can be increased when it is combined with Fosaprepitant.
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Fosaprepitant.
TolbutamideThe serum concentration of Tolbutamide can be decreased when it is combined with Fosaprepitant.
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Fosaprepitant.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Fosaprepitant.
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Fosaprepitant.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Fosaprepitant.
TramadolThe serum concentration of Tramadol can be increased when it is combined with Fosaprepitant.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Fosaprepitant.
TrazodoneThe serum concentration of Trazodone can be increased when it is combined with Fosaprepitant.
TretinoinThe serum concentration of Tretinoin can be increased when it is combined with Fosaprepitant.
TriamcinoloneThe serum concentration of Triamcinolone can be increased when it is combined with Fosaprepitant.
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Fosaprepitant.
TrimethadioneThe serum concentration of Trimethadione can be increased when it is combined with Fosaprepitant.
TrimethoprimThe serum concentration of Trimethoprim can be increased when it is combined with Fosaprepitant.
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Fosaprepitant.
TroglitazoneThe serum concentration of Troglitazone can be increased when it is combined with Fosaprepitant.
TroleandomycinThe serum concentration of Troleandomycin can be increased when it is combined with Fosaprepitant.
UdenafilThe serum concentration of Udenafil can be increased when it is combined with Fosaprepitant.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Fosaprepitant.
ValdecoxibThe serum concentration of Valdecoxib can be increased when it is combined with Fosaprepitant.
VandetanibThe serum concentration of Vandetanib can be increased when it is combined with Fosaprepitant.
VanoxerineThe serum concentration of Vanoxerine can be increased when it is combined with Fosaprepitant.
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Fosaprepitant.
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Fosaprepitant.
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Fosaprepitant.
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Fosaprepitant.
VicrivirocThe serum concentration of Vicriviroc can be increased when it is combined with Fosaprepitant.
VilanterolThe serum concentration of Vilanterol can be increased when it is combined with Fosaprepitant.
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Fosaprepitant.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Fosaprepitant.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Fosaprepitant.
VindesineThe serum concentration of Vindesine can be increased when it is combined with Fosaprepitant.
VinorelbineThe serum concentration of Vinorelbine can be increased when it is combined with Fosaprepitant.
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Fosaprepitant.
VoriconazoleThe serum concentration of Voriconazole can be increased when it is combined with Fosaprepitant.
VortioxetineThe serum concentration of Vortioxetine can be increased when it is combined with Fosaprepitant.
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Fosaprepitant.
YohimbineThe serum concentration of Yohimbine can be increased when it is combined with Fosaprepitant.
ZafirlukastThe serum concentration of Zafirlukast can be increased when it is combined with Fosaprepitant.
ZalcitabineThe serum concentration of Zalcitabine can be increased when it is combined with Fosaprepitant.
ZaleplonThe serum concentration of Zaleplon can be increased when it is combined with Fosaprepitant.
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Fosaprepitant.
ZileutonThe serum concentration of Zileuton can be increased when it is combined with Fosaprepitant.
ZiprasidoneThe serum concentration of Ziprasidone can be increased when it is combined with Fosaprepitant.
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Fosaprepitant.
ZomepiracThe serum concentration of Zomepirac can be increased when it is combined with Fosaprepitant.
ZonisamideThe serum concentration of Zonisamide can be increased when it is combined with Fosaprepitant.
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Fosaprepitant.
Food InteractionsNot Available
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Drug created on May 16, 2010 18:16 / Updated on September 26, 2016 02:13