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Identification
NameAprepitant
Accession NumberDB00673  (APRD00100)
TypeSmall Molecule
GroupsApproved, Investigational
DescriptionAprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. Aprepitant has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors, the targets of existing therapies for chemotherapy-induced nausea and vomiting (CI NV).
Structure
Thumb
Synonyms
3-(((2R,3S)-3-(P-Fluorophenyl)-2-(((alphar)-alpha-methyl-3,5-bis(trifluoromethyl)benzyl)oxy)morpholino)methyl)-delta(2)-1,2,4-triazolin-5-one
Aprepitant
Aprépitant
Aprepitantum
External Identifiers
  • L 754030
  • L-754939
  • MK-0517
  • MK-869
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Emendpowder, for suspension125 mg/1oralMerck Sharp & Dohme Corp.2015-12-17Not applicableUs
Emendcapsule80 mg/1oralMerck Sharp & Dohme Corp.2003-03-26Not applicableUs
EmendCapsule, hard40 mgOral useMerck Sharp & Dohme Ltd.2003-11-11Not applicableEu
EmendCapsule, hard80 mgOral useMerck Sharp & Dohme Ltd.2003-11-11Not applicableEu
Emendcapsule40 mg/1oralRebel Distributors Corp2003-03-26Not applicableUs
EmendPowder for oral suspension125 mgOral useMerck Sharp & Dohme Ltd.2003-11-11Not applicableEu
Emendcapsule80 mgoralMerck Canada Inc2007-09-24Not applicableCanada
Emendcapsule125 mg/1oralMerck Sharp & Dohme Corp.2003-03-26Not applicableUs
EmendCapsule, hard40 mgOral useMerck Sharp & Dohme Ltd.2003-11-11Not applicableEu
EmendCapsule, hard80 mgOral useMerck Sharp & Dohme Ltd.2003-11-11Not applicableEu
Emendcapsule80 mg/1oralPhysicians Total Care, Inc.2005-06-29Not applicableUs
Emendcapsule125 mgoralMerck Canada Inc2007-09-24Not applicableCanada
Emendcapsule40 mg/1oralMerck Sharp & Dohme Corp.2003-03-26Not applicableUs
EmendCapsule, hard165 mgOral useMerck Sharp & Dohme Ltd.2003-11-11Not applicableEu
EmendCapsule, hard125 mgOral useMerck Sharp & Dohme Ltd.2003-11-11Not applicableEu
EmendkitPhysicians Total Care, Inc.2005-06-24Not applicableUs
EmendCapsule, hard80 mgOral useMerck Sharp & Dohme Ltd.2003-11-11Not applicableEu
EmendkitMerck Sharp & Dohme Corp.2003-03-26Not applicableUs
EmendCapsule, hard165 mgOral useMerck Sharp & Dohme Ltd.2003-11-11Not applicableEu
EmendCapsule, hard125 mgOral useMerck Sharp & Dohme Ltd.2003-11-11Not applicableEu
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AprecapGlenmark
Brand mixtures
NameLabellerIngredients
Emend Tri-packMerck Canada Inc
SaltsNot Available
Categories
UNII1NF15YR6UY
CAS number170729-80-3
WeightAverage: 534.4267
Monoisotopic: 534.150187993
Chemical FormulaC23H21F7N4O3
InChI KeyInChIKey=ATALOFNDEOCMKK-OITMNORJSA-N
InChI
InChI=1S/C23H21F7N4O3/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)37-20-19(13-2-4-17(24)5-3-13)34(6-7-36-20)11-18-31-21(35)33-32-18/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H2,31,32,33,35)/t12-,19+,20-/m1/s1
IUPAC Name
3-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-4,5-dihydro-1H-1,2,4-triazol-5-one
SMILES
C[C@@H](O[[email protected]]1OCCN(CC2=NNC(=O)N2)[[email protected]]1C1=CC=C(F)C=C1)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenylmorpholines. These are aromatic compounds containing a morpholine ring and a benzene ring linked to each other through a CC or a CN bond.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassOxazinanes
Sub ClassMorpholines
Direct ParentPhenylmorpholines
Alternative Parents
Substituents
  • Phenylmorpholine
  • Aralkylamine
  • Halobenzene
  • Fluorobenzene
  • Benzenoid
  • Monocyclic benzene moiety
  • Aryl halide
  • Aryl fluoride
  • Heteroaromatic compound
  • 1,2,4-triazole
  • Azole
  • Tertiary aliphatic amine
  • Tertiary amine
  • Oxacycle
  • Azacycle
  • Acetal
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organofluoride
  • Organohalogen compound
  • Amine
  • Alkyl halide
  • Alkyl fluoride
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationFor the prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy, including high-dose cisplatin (in combination with other antiemetic agents).
PharmacodynamicsAprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. Aprepitant has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors, the targets of existing therapies for chemotherapy-induced nausea and vomiting (CI NV).
Mechanism of actionAprepitant has been shown in animal models to inhibit emesis induced by cytotoxic chemotherapeutic agents, such as cisplatin, via central actions. Animal and human Positron Emission Tomography (PET) studies with Aprepitant have shown that it crosses the blood brain barrier and occupies brain NK1 receptors. Animal and human studies show that Aprepitant augments the antiemetic activity of the 5-HT3-receptor antagonist ondansetron and the corticosteroid ethasone and inhibits both the acute and delayed phases of cisplatin induced emesis.
Related Articles
AbsorptionThe mean absolute oral bioavailability of aprepitant is approximately 60 to 65%.
Volume of distribution
  • 70 L
Protein binding>95%
Metabolism

Aprepitant is metabolized primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19. Seven metabolites of aprepitant, which are only weakly active, have been identified in human plasma.

SubstrateEnzymesProduct
Aprepitant
(2S,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholineDetails
Aprepitant
5-({[(1R)-1-(4-fluorophenyl)-2-hydroxyethyl]amino}methyl)-2,3-dihydro-1H-1,2,4-triazol-3-oneDetails
Aprepitant
(2R)-2-(4-fluorophenyl)-2-{[(5-oxo-2,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]amino}acetic acidDetails
Route of eliminationAprepitant is eliminated primarily by metabolism; aprepitant is not renally excreted. Aprepitant is excreted in the milk of rats. It is not known whether this drug is excreted in human milk.
Half life9-13 hours
Clearance
  • Apparent plasma cl=62-90 mL/min
ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9952
Blood Brain Barrier+0.5588
Caco-2 permeable-0.6237
P-glycoprotein substrateSubstrate0.8106
P-glycoprotein inhibitor IInhibitor0.5243
P-glycoprotein inhibitor IINon-inhibitor0.9564
Renal organic cation transporterNon-inhibitor0.7444
CYP450 2C9 substrateNon-substrate0.788
CYP450 2D6 substrateNon-substrate0.9115
CYP450 3A4 substrateSubstrate0.6461
CYP450 1A2 substrateNon-inhibitor0.6012
CYP450 2C9 inhibitorNon-inhibitor0.535
CYP450 2D6 inhibitorNon-inhibitor0.84
CYP450 2C19 inhibitorNon-inhibitor0.5862
CYP450 3A4 inhibitorInhibitor0.5
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.8396
Ames testNon AMES toxic0.5758
CarcinogenicityNon-carcinogens0.8152
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.6055 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.6598
hERG inhibition (predictor II)Inhibitor0.8163
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Merck and co inc
Packagers
Dosage forms
FormRouteStrength
Capsuleoral125 mg
Capsuleoral125 mg/1
Capsuleoral40 mg/1
Capsuleoral80 mg/1
Capsuleoral80 mg
Capsule, hardOral use125 mg
Capsule, hardOral use165 mg
Capsule, hardOral use40 mg
Capsule, hardOral use80 mg
Kit
Powder for oral suspensionOral use125 mg
Powder, for suspensionoral125 mg/1
Kit; capsuleoral
Prices
Unit descriptionCostUnit
Emend 6 125 mg capsule Box1046.01USD box
Emend 6 80 mg capsule Box678.62USD box
Emend 5 80 mg capsule Box553.13USD box
Emend 3 80 & 125 mg capsule Disp Pack415.76USD disp
Emend 115 mg Solution 1 Vial = 10ml242.13USD vial
Emend 115 mg vial232.82USD vial
Emend 2 80 mg capsule Disp Pack226.21USD disp
Emend 125 mg capsule161.34USD capsule
Emend 80 mg capsule108.76USD capsule
Emend 40 mg capsule Box58.17USD box
Emend 40 mg capsule55.89USD capsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2469315 No2008-12-022022-12-19Canada
US5145684 No1994-01-252011-01-25Us
US6096742 No1998-07-012018-07-01Us
US8258132 No2007-09-262027-09-26Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
water solubilityPractically insolubleNot Available
logP4.5Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0194 mg/mLALOGPS
logP2.44ALOGPS
logP5.22ChemAxon
logS-4.4ALOGPS
pKa (Strongest Acidic)9.65ChemAxon
pKa (Strongest Basic)3.51ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area75.19 Å2ChemAxon
Rotatable Bond Count8ChemAxon
Refractivity116.93 m3·mol-1ChemAxon
Polarizability45.56 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

Mangesh Shivram Sawant, Girish Dixit, Nitin Sharad Chandra Pradhan, Mubeen Ahmad Khan, Sukumar Sinha, “Amorphous and Crystalline Forms of Aprepitant and Processes for the Preparation Thereof.” U.S. Patent US20090192161, issued July 30, 2009.

US20090192161
General ReferencesNot Available
External Links
ATC CodesA04AD12
AHFS Codes
  • 56:22.92
PDB EntriesNot Available
FDA labelDownload (293 KB)
MSDSNot Available
Interactions
Drug Interactions
Drug
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be increased when it is combined with Aprepitant.
AbirateroneThe serum concentration of Abiraterone can be increased when it is combined with Aprepitant.
AceclofenacThe metabolism of Aceclofenac can be increased when combined with Aprepitant.
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Aprepitant.
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Aprepitant.
Acetylsalicylic acidThe metabolism of Acetylsalicylic acid can be increased when combined with Aprepitant.
AdinazolamThe serum concentration of Adinazolam can be increased when it is combined with Aprepitant.
AlbendazoleThe serum concentration of Albendazole can be increased when it is combined with Aprepitant.
AlclometasoneThe serum concentration of Alclometasone can be increased when it is combined with Aprepitant.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Aprepitant.
AlfentanilThe serum concentration of Alfentanil can be increased when it is combined with Aprepitant.
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Aprepitant.
AliskirenThe serum concentration of Aliskiren can be increased when it is combined with Aprepitant.
AllylestrenolThe serum concentration of Allylestrenol can be increased when it is combined with Aprepitant.
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Aprepitant.
AlogliptinThe serum concentration of Alogliptin can be increased when it is combined with Aprepitant.
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Aprepitant.
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Aprepitant.
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Aprepitant.
AmbroxolThe serum concentration of Ambroxol can be increased when it is combined with Aprepitant.
AmcinonideThe serum concentration of Amcinonide can be increased when it is combined with Aprepitant.
AminophenazoneThe serum concentration of Aminophenazone can be increased when it is combined with Aprepitant.
AminophyllineThe serum concentration of Aminophylline can be increased when it is combined with Aprepitant.
AmiodaroneThe serum concentration of Amiodarone can be increased when it is combined with Aprepitant.
AmiodaroneThe metabolism of Aprepitant can be decreased when combined with Amiodarone.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Aprepitant.
AmlodipineThe serum concentration of Amlodipine can be increased when it is combined with Aprepitant.
AmprenavirThe serum concentration of Amprenavir can be increased when it is combined with Aprepitant.
AntipyrineThe serum concentration of Antipyrine can be increased when it is combined with Aprepitant.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Aprepitant.
ApremilastThe serum concentration of Apremilast can be increased when it is combined with Aprepitant.
Arachidonic AcidThe metabolism of Arachidonic Acid can be increased when combined with Aprepitant.
ArformoterolThe metabolism of Arformoterol can be increased when combined with Aprepitant.
ArgatrobanThe serum concentration of Argatroban can be increased when it is combined with Aprepitant.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Aprepitant.
ArmodafinilThe metabolism of Aprepitant can be decreased when combined with Armodafinil.
ArtemetherThe serum concentration of Artemether can be increased when it is combined with Aprepitant.
AsenapineThe serum concentration of Asenapine can be increased when it is combined with Aprepitant.
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Aprepitant.
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Aprepitant.
AtazanavirThe metabolism of Aprepitant can be decreased when combined with Atazanavir.
AtomoxetineThe metabolism of Aprepitant can be decreased when combined with Atomoxetine.
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Aprepitant.
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Aprepitant.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Aprepitant.
AzelastineThe serum concentration of Azelastine can be increased when it is combined with Aprepitant.
AzithromycinThe serum concentration of Azithromycin can be increased when it is combined with Aprepitant.
AzithromycinThe metabolism of Aprepitant can be decreased when combined with Azithromycin.
BanoxantroneThe serum concentration of Banoxantrone can be increased when it is combined with Aprepitant.
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be increased when it is combined with Aprepitant.
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Aprepitant.
BenzphetamineThe serum concentration of Benzphetamine can be increased when it is combined with Aprepitant.
Benzyl alcoholThe serum concentration of Benzyl alcohol can be increased when it is combined with Aprepitant.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Aprepitant.
BexaroteneThe serum concentration of Bexarotene can be increased when it is combined with Aprepitant.
BexaroteneThe serum concentration of Aprepitant can be decreased when it is combined with Bexarotene.
BezafibrateThe serum concentration of Bezafibrate can be increased when it is combined with Aprepitant.
BicalutamideThe serum concentration of Bicalutamide can be increased when it is combined with Aprepitant.
BisoprololThe serum concentration of Bisoprolol can be increased when it is combined with Aprepitant.
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Aprepitant.
BoceprevirThe metabolism of Aprepitant can be decreased when combined with Boceprevir.
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Aprepitant.
BortezomibThe metabolism of Aprepitant can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Aprepitant.
BosentanThe serum concentration of Aprepitant can be decreased when it is combined with Bosentan.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Aprepitant.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Aprepitant.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Aprepitant.
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Aprepitant.
BromazepamThe serum concentration of Bromazepam can be increased when it is combined with Aprepitant.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Aprepitant.
BrompheniramineThe serum concentration of Brompheniramine can be increased when it is combined with Aprepitant.
BudesonideThe metabolism of Budesonide can be decreased when combined with Aprepitant.
BupivacaineThe serum concentration of Bupivacaine can be increased when it is combined with Aprepitant.
BuprenorphineThe serum concentration of Buprenorphine can be increased when it is combined with Aprepitant.
BupropionThe serum concentration of Bupropion can be increased when it is combined with Aprepitant.
BuspironeThe serum concentration of Buspirone can be increased when it is combined with Aprepitant.
BusulfanThe serum concentration of Busulfan can be increased when it is combined with Aprepitant.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Aprepitant.
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Aprepitant.
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Aprepitant.
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Aprepitant.
CaffeineThe metabolism of Aprepitant can be decreased when combined with Caffeine.
CalcitriolThe serum concentration of Calcitriol can be increased when it is combined with Aprepitant.
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Aprepitant.
CandesartanThe metabolism of Candesartan can be increased when combined with Aprepitant.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Aprepitant.
CarbamazepineThe metabolism of Aprepitant can be increased when combined with Carbamazepine.
CarbinoxamineThe serum concentration of Carbinoxamine can be increased when it is combined with Aprepitant.
CariprazineThe serum concentration of Cariprazine can be increased when it is combined with Aprepitant.
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Aprepitant.
CelecoxibThe serum concentration of Celecoxib can be increased when it is combined with Aprepitant.
CeliprololThe serum concentration of Celiprolol can be increased when it is combined with Aprepitant.
CephalexinThe serum concentration of Cephalexin can be increased when it is combined with Aprepitant.
CeritinibThe serum concentration of Aprepitant can be increased when it is combined with Ceritinib.
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Aprepitant.
CevimelineThe serum concentration of Cevimeline can be increased when it is combined with Aprepitant.
Chenodeoxycholic acidThe serum concentration of Chenodeoxycholic acid can be increased when it is combined with Aprepitant.
ChloramphenicolThe metabolism of Aprepitant can be decreased when combined with Chloramphenicol.
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be increased when it is combined with Aprepitant.
ChloroquineThe serum concentration of Chloroquine can be increased when it is combined with Aprepitant.
ChlorphenamineThe serum concentration of Chlorphenamine can be increased when it is combined with Aprepitant.
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Aprepitant.
ChlorpropamideThe metabolism of Chlorpropamide can be increased when combined with Aprepitant.
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be increased when it is combined with Aprepitant.
CholecalciferolThe serum concentration of Cholecalciferol can be increased when it is combined with Aprepitant.
CholecalciferolThe metabolism of Aprepitant can be decreased when combined with Cholecalciferol.
CiclesonideThe serum concentration of Ciclesonide can be increased when it is combined with Aprepitant.
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Aprepitant.
CimetidineThe metabolism of Aprepitant can be decreased when combined with Cimetidine.
CinacalcetThe serum concentration of Cinacalcet can be increased when it is combined with Aprepitant.
CinnarizineThe metabolism of Cinnarizine can be increased when combined with Aprepitant.
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Aprepitant.
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Aprepitant.
CitalopramThe metabolism of Aprepitant can be decreased when combined with Citalopram.
ClarithromycinThe serum concentration of Clarithromycin can be increased when it is combined with Aprepitant.
ClarithromycinThe metabolism of Aprepitant can be decreased when combined with Clarithromycin.
ClemastineThe metabolism of Aprepitant can be decreased when combined with Clemastine.
ClindamycinThe serum concentration of Clindamycin can be increased when it is combined with Aprepitant.
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Aprepitant.
Clobetasol propionateThe serum concentration of Clobetasol propionate can be increased when it is combined with Aprepitant.
ClocortoloneThe serum concentration of Clocortolone can be increased when it is combined with Aprepitant.
ClofazimineThe serum concentration of Clofazimine can be increased when it is combined with Aprepitant.
ClofibrateThe serum concentration of Clofibrate can be increased when it is combined with Aprepitant.
clomethiazoleThe serum concentration of clomethiazole can be increased when it is combined with Aprepitant.
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Aprepitant.
ClonazepamThe serum concentration of Clonazepam can be increased when it is combined with Aprepitant.
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Aprepitant.
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Aprepitant.
ClorazepateThe serum concentration of Clorazepate can be increased when it is combined with Aprepitant.
ClotiazepamThe serum concentration of Clotiazepam can be increased when it is combined with Aprepitant.
ClotrimazoleThe metabolism of Aprepitant can be decreased when combined with Clotrimazole.
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Aprepitant.
CobicistatThe metabolism of Aprepitant can be decreased when combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Aprepitant.
CocaineThe serum concentration of Cocaine can be increased when it is combined with Aprepitant.
CodeineThe serum concentration of Codeine can be increased when it is combined with Aprepitant.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Aprepitant.
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Aprepitant.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Aprepitant.
Cortisone acetateThe serum concentration of Cortisone acetate can be increased when it is combined with Aprepitant.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Aprepitant.
CrizotinibThe metabolism of Aprepitant can be decreased when combined with Crizotinib.
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Aprepitant.
CyclophosphamideThe serum concentration of Cyclophosphamide can be increased when it is combined with Aprepitant.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Aprepitant.
CyclosporineThe metabolism of Aprepitant can be decreased when combined with Cyclosporine.
Cyproterone acetateThe serum concentration of Aprepitant can be decreased when it is combined with Cyproterone acetate.
CytarabineThe serum concentration of Cytarabine can be increased when it is combined with Aprepitant.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Aprepitant.
DabrafenibThe serum concentration of Aprepitant can be decreased when it is combined with Dabrafenib.
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Aprepitant.
DantroleneThe serum concentration of Dantrolene can be increased when it is combined with Aprepitant.
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Aprepitant.
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Aprepitant.
DapsoneThe serum concentration of Dapsone can be increased when it is combined with Aprepitant.
DarifenacinThe serum concentration of Darifenacin can be increased when it is combined with Aprepitant.
DarunavirThe serum concentration of Darunavir can be increased when it is combined with Aprepitant.
DarunavirThe metabolism of Aprepitant can be decreased when combined with Darunavir.
DasabuvirThe serum concentration of Dasabuvir can be increased when it is combined with Aprepitant.
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Aprepitant.
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Aprepitant.
DeferasiroxThe serum concentration of Aprepitant can be decreased when it is combined with Deferasirox.
DehydroepiandrosteroneThe serum concentration of Dehydroepiandrosterone can be increased when it is combined with Aprepitant.
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be increased when it is combined with Aprepitant.
DelavirdineThe serum concentration of Delavirdine can be increased when it is combined with Aprepitant.
DelavirdineThe metabolism of Aprepitant can be decreased when combined with Delavirdine.
DesoximetasoneThe serum concentration of Desoximetasone can be increased when it is combined with Aprepitant.
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be increased when it is combined with Aprepitant.
DesvenlafaxineThe serum concentration of Desvenlafaxine can be increased when it is combined with Aprepitant.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Aprepitant.
DexamethasoneThe serum concentration of Aprepitant can be decreased when it is combined with Dexamethasone.
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Aprepitant.
DextromethorphanThe serum concentration of Dextromethorphan can be increased when it is combined with Aprepitant.
DextropropoxypheneThe serum concentration of Dextropropoxyphene can be increased when it is combined with Aprepitant.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Aprepitant.
DiclofenacThe serum concentration of Diclofenac can be decreased when it is combined with Aprepitant.
DicoumarolThe metabolism of Dicoumarol can be increased when combined with Aprepitant.
DiflorasoneThe serum concentration of Diflorasone can be increased when it is combined with Aprepitant.
DifluocortoloneThe serum concentration of Difluocortolone can be increased when it is combined with Aprepitant.
DifluprednateThe serum concentration of Difluprednate can be increased when it is combined with Aprepitant.
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Aprepitant.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Aprepitant.
DihydrocodeineThe serum concentration of Dihydrocodeine can be increased when it is combined with Aprepitant.
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Aprepitant.
DihydroergotamineThe metabolism of Aprepitant can be decreased when combined with Dihydroergotamine.
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Aprepitant.
DiltiazemThe metabolism of Aprepitant can be decreased when combined with Diltiazem.
DiphenhydramineThe metabolism of Diphenhydramine can be increased when combined with Aprepitant.
DisopyramideThe serum concentration of Disopyramide can be increased when it is combined with Aprepitant.
DisulfiramThe serum concentration of Disulfiram can be increased when it is combined with Aprepitant.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Aprepitant.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Aprepitant.
DolasetronThe serum concentration of Dolasetron can be increased when it is combined with Aprepitant.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Aprepitant.
DonepezilThe serum concentration of Donepezil can be increased when it is combined with Aprepitant.
DopamineThe metabolism of Dopamine can be increased when combined with Aprepitant.
DorzolamideThe serum concentration of Dorzolamide can be increased when it is combined with Aprepitant.
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Aprepitant.
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Aprepitant.
DoxycyclineThe metabolism of Aprepitant can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Aprepitant.
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Aprepitant.
DronedaroneThe metabolism of Aprepitant can be decreased when combined with Dronedarone.
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Aprepitant.
EfavirenzThe serum concentration of Efavirenz can be increased when it is combined with Aprepitant.
EfavirenzThe serum concentration of Aprepitant can be decreased when it is combined with Efavirenz.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Aprepitant.
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Aprepitant.
ElvitegravirThe serum concentration of Elvitegravir can be increased when it is combined with Aprepitant.
EnalaprilThe serum concentration of Enalapril can be increased when it is combined with Aprepitant.
EnzalutamideThe serum concentration of Enzalutamide can be increased when it is combined with Aprepitant.
EnzalutamideThe serum concentration of Aprepitant can be decreased when it is combined with Enzalutamide.
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Aprepitant.
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Aprepitant.
EpoprostenolThe metabolism of Epoprostenol can be increased when combined with Aprepitant.
EquileninThe serum concentration of Equilenin can be increased when it is combined with Aprepitant.
EquilinThe serum concentration of Equilin can be increased when it is combined with Aprepitant.
ErgocalciferolThe serum concentration of Ergocalciferol can be increased when it is combined with Aprepitant.
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Aprepitant.
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Aprepitant.
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Aprepitant.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Aprepitant.
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Aprepitant.
ErythromycinThe metabolism of Aprepitant can be decreased when combined with Erythromycin.
EscitalopramThe serum concentration of Escitalopram can be increased when it is combined with Aprepitant.
Eslicarbazepine acetateThe serum concentration of Aprepitant can be decreased when it is combined with Eslicarbazepine acetate.
EsomeprazoleThe serum concentration of Esomeprazole can be increased when it is combined with Aprepitant.
EsomeprazoleThe metabolism of Aprepitant can be decreased when combined with Esomeprazole.
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Aprepitant.
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Aprepitant.
Estradiol valerate/DienogestThe serum concentration of Estradiol valerate/Dienogest can be increased when it is combined with Aprepitant.
EstramustineThe serum concentration of Estramustine can be increased when it is combined with Aprepitant.
EstroneThe serum concentration of Estrone can be increased when it is combined with Aprepitant.
Estrone sulfateThe serum concentration of Estrone sulfate can be increased when it is combined with Aprepitant.
EszopicloneThe serum concentration of Eszopiclone can be increased when it is combined with Aprepitant.
EthanolThe serum concentration of Ethanol can be increased when it is combined with Aprepitant.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Aprepitant.
EthosuximideThe serum concentration of Ethosuximide can be increased when it is combined with Aprepitant.
EthylmorphineThe serum concentration of Ethylmorphine can be increased when it is combined with Aprepitant.
EtodolacThe metabolism of Etodolac can be increased when combined with Aprepitant.
EtonogestrelThe serum concentration of Etonogestrel can be increased when it is combined with Aprepitant.
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Aprepitant.
EtoricoxibThe serum concentration of Etoricoxib can be increased when it is combined with Aprepitant.
EtravirineThe serum concentration of Etravirine can be increased when it is combined with Aprepitant.
EtravirineThe serum concentration of Aprepitant can be decreased when it is combined with Etravirine.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Aprepitant.
ExemestaneThe serum concentration of Exemestane can be increased when it is combined with Aprepitant.
FamciclovirThe serum concentration of Famciclovir can be increased when it is combined with Aprepitant.
FelbamateThe serum concentration of Felbamate can be increased when it is combined with Aprepitant.
FelodipineThe serum concentration of Felodipine can be increased when it is combined with Aprepitant.
FenofibrateThe serum concentration of Fenofibrate can be increased when it is combined with Aprepitant.
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Aprepitant.
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Aprepitant.
FinasterideThe serum concentration of Finasteride can be increased when it is combined with Aprepitant.
FingolimodThe serum concentration of Fingolimod can be increased when it is combined with Aprepitant.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Aprepitant.
FluconazoleThe metabolism of Aprepitant can be decreased when combined with Fluconazole.
FludrocortisoneThe serum concentration of Fludrocortisone can be increased when it is combined with Aprepitant.
FlumethasoneThe serum concentration of Flumethasone can be increased when it is combined with Aprepitant.
FlunarizineThe metabolism of Flunarizine can be increased when combined with Aprepitant.
FlunisolideThe serum concentration of Flunisolide can be increased when it is combined with Aprepitant.
FlunitrazepamThe serum concentration of Flunitrazepam can be increased when it is combined with Aprepitant.
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be increased when it is combined with Aprepitant.
FluocinonideThe serum concentration of Fluocinonide can be increased when it is combined with Aprepitant.
FluocortoloneThe serum concentration of Fluocortolone can be increased when it is combined with Aprepitant.
FluorometholoneThe serum concentration of Fluorometholone can be increased when it is combined with Aprepitant.
FluoxetineThe serum concentration of Fluoxetine can be increased when it is combined with Aprepitant.
FluoxetineThe metabolism of Aprepitant can be decreased when combined with Fluoxetine.
FluprednideneThe serum concentration of Fluprednidene can be increased when it is combined with Aprepitant.
FluprednisoloneThe serum concentration of Fluprednisolone can be increased when it is combined with Aprepitant.
FlurandrenolideThe serum concentration of Flurandrenolide can be increased when it is combined with Aprepitant.
FlurazepamThe serum concentration of Flurazepam can be increased when it is combined with Aprepitant.
FlurbiprofenThe metabolism of Flurbiprofen can be increased when combined with Aprepitant.
FlutamideThe serum concentration of Flutamide can be increased when it is combined with Aprepitant.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Aprepitant.
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Aprepitant.
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Aprepitant.
FluvoxamineThe metabolism of Aprepitant can be decreased when combined with Fluvoxamine.
FormoterolThe metabolism of Formoterol can be increased when combined with Aprepitant.
FosamprenavirThe serum concentration of Fosamprenavir can be increased when it is combined with Aprepitant.
FosamprenavirThe metabolism of Aprepitant can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Aprepitant can be increased when it is combined with Fosaprepitant.
FosphenytoinThe metabolism of Aprepitant can be increased when combined with Fosphenytoin.
FulvestrantThe serum concentration of Fulvestrant can be increased when it is combined with Aprepitant.
Fusidic AcidThe serum concentration of Aprepitant can be increased when it is combined with Fusidic Acid.
GalantamineThe serum concentration of Galantamine can be increased when it is combined with Aprepitant.
GavestinelThe metabolism of Gavestinel can be increased when combined with Aprepitant.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Aprepitant.
GemfibrozilThe serum concentration of Gemfibrozil can be increased when it is combined with Aprepitant.
GemfibrozilThe metabolism of Aprepitant can be decreased when combined with Gemfibrozil.
GliclazideThe metabolism of Gliclazide can be increased when combined with Aprepitant.
GlimepirideThe metabolism of Glimepiride can be increased when combined with Aprepitant.
GlipizideThe serum concentration of Glipizide can be increased when it is combined with Aprepitant.
GlyburideThe serum concentration of Glyburide can be increased when it is combined with Aprepitant.
GranisetronThe serum concentration of Granisetron can be increased when it is combined with Aprepitant.
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Aprepitant.
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Aprepitant.
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Aprepitant.
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Aprepitant.
HalothaneThe serum concentration of Halothane can be increased when it is combined with Aprepitant.
HexobarbitalThe serum concentration of Hexobarbital can be increased when it is combined with Aprepitant.
Histamine PhosphateThe serum concentration of Histamine Phosphate can be increased when it is combined with Aprepitant.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Aprepitant.
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Aprepitant.
HydromorphoneThe serum concentration of Hydromorphone can be increased when it is combined with Aprepitant.
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be increased when it is combined with Aprepitant.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Aprepitant.
IbuprofenThe metabolism of Ibuprofen can be increased when combined with Aprepitant.
IdarubicinThe metabolism of Idarubicin can be increased when combined with Aprepitant.
IdelalisibThe serum concentration of Aprepitant can be increased when it is combined with Idelalisib.
IfosfamideThe serum concentration of Ifosfamide can be increased when it is combined with Aprepitant.
IloperidoneThe serum concentration of Iloperidone can be increased when it is combined with Aprepitant.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Aprepitant.
ImatinibThe metabolism of Aprepitant can be decreased when combined with Imatinib.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Aprepitant.
ImiquimodThe serum concentration of Imiquimod can be increased when it is combined with Aprepitant.
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Aprepitant.
IndapamideThe serum concentration of Indapamide can be increased when it is combined with Aprepitant.
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Aprepitant.
IndinavirThe metabolism of Aprepitant can be decreased when combined with Indinavir.
indisulamThe metabolism of indisulam can be increased when combined with Aprepitant.
IndomethacinThe metabolism of Indomethacin can be increased when combined with Aprepitant.
Ipratropium bromideThe serum concentration of Ipratropium bromide can be increased when it is combined with Aprepitant.
IrbesartanThe metabolism of Irbesartan can be increased when combined with Aprepitant.
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Aprepitant.
IsavuconazoniumThe serum concentration of Isavuconazonium can be increased when it is combined with Aprepitant.
IsavuconazoniumThe metabolism of Aprepitant can be decreased when combined with Isavuconazonium.
IsoniazidThe metabolism of Aprepitant can be decreased when combined with Isoniazid.
Isosorbide DinitrateThe serum concentration of Isosorbide Dinitrate can be increased when it is combined with Aprepitant.
Isosorbide MononitrateThe serum concentration of Isosorbide Mononitrate can be increased when it is combined with Aprepitant.
IsradipineThe serum concentration of Isradipine can be increased when it is combined with Aprepitant.
IsradipineThe metabolism of Aprepitant can be decreased when combined with Isradipine.
ItraconazoleThe serum concentration of Itraconazole can be increased when it is combined with Aprepitant.
ItraconazoleThe metabolism of Aprepitant can be decreased when combined with Itraconazole.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Aprepitant.
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Aprepitant.
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Aprepitant.
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Aprepitant.
IxazomibThe serum concentration of Ixazomib can be increased when it is combined with Aprepitant.
KetamineThe serum concentration of Ketamine can be increased when it is combined with Aprepitant.
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Aprepitant.
KetobemidoneThe serum concentration of Ketobemidone can be increased when it is combined with Aprepitant.
KetoconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Aprepitant.
KetoconazoleThe metabolism of Aprepitant can be decreased when combined with Ketoconazole.
KetoprofenThe metabolism of Ketoprofen can be increased when combined with Aprepitant.
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Aprepitant.
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Aprepitant.
LaquinimodThe serum concentration of Laquinimod can be increased when it is combined with Aprepitant.
LeflunomideThe metabolism of Leflunomide can be increased when combined with Aprepitant.
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Aprepitant.
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Aprepitant.
LesinuradThe metabolism of Lesinurad can be increased when combined with Aprepitant.
LetrozoleThe serum concentration of Letrozole can be increased when it is combined with Aprepitant.
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Aprepitant.
LevocetirizineThe serum concentration of Levocetirizine can be increased when it is combined with Aprepitant.
Levomethadyl AcetateThe serum concentration of Levomethadyl Acetate can be increased when it is combined with Aprepitant.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Aprepitant.
LevonorgestrelThe serum concentration of Levonorgestrel can be increased when it is combined with Aprepitant.
LevothyroxineThe serum concentration of Levothyroxine can be increased when it is combined with Aprepitant.
LicofeloneThe metabolism of Licofelone can be increased when combined with Aprepitant.
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Aprepitant.
LidocaineThe metabolism of Aprepitant can be decreased when combined with Lidocaine.
LisurideThe serum concentration of Lisuride can be increased when it is combined with Aprepitant.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Aprepitant.
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Aprepitant.
LopinavirThe serum concentration of Lopinavir can be increased when it is combined with Aprepitant.
LopinavirThe metabolism of Aprepitant can be decreased when combined with Lopinavir.
LoratadineThe serum concentration of Loratadine can be increased when it is combined with Aprepitant.
LorcaserinThe serum concentration of Lorcaserin can be increased when it is combined with Aprepitant.
LornoxicamThe metabolism of Lornoxicam can be increased when combined with Aprepitant.
LosartanThe serum concentration of Losartan can be increased when it is combined with Aprepitant.
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Aprepitant.
LovastatinThe metabolism of Aprepitant can be decreased when combined with Lovastatin.
LuliconazoleThe serum concentration of Aprepitant can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Aprepitant can be decreased when it is combined with Lumacaftor.
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Aprepitant.
LumiracoxibThe metabolism of Lumiracoxib can be increased when combined with Aprepitant.
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Aprepitant.
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Aprepitant.
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Aprepitant.
MebendazoleThe serum concentration of Mebendazole can be increased when it is combined with Aprepitant.
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Aprepitant.
MedrysoneThe serum concentration of Medrysone can be increased when it is combined with Aprepitant.
Mefenamic acidThe metabolism of Mefenamic acid can be increased when combined with Aprepitant.
MefloquineThe serum concentration of Mefloquine can be increased when it is combined with Aprepitant.
MelatoninThe metabolism of Melatonin can be increased when combined with Aprepitant.
MelengestrolThe serum concentration of Melengestrol can be increased when it is combined with Aprepitant.
MeloxicamThe serum concentration of Meloxicam can be increased when it is combined with Aprepitant.
MephenytoinThe metabolism of Mephenytoin can be increased when combined with Aprepitant.
MestranolThe metabolism of Mestranol can be increased when combined with Aprepitant.
MethadoneThe serum concentration of Methadone can be increased when it is combined with Aprepitant.
MethaqualoneThe serum concentration of Methaqualone can be increased when it is combined with Aprepitant.
MethoxsalenThe serum concentration of Methoxsalen can be increased when it is combined with Aprepitant.
MethoxyfluraneThe serum concentration of Methoxyflurane can be increased when it is combined with Aprepitant.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Aprepitant.
MethyltestosteroneThe serum concentration of Methyltestosterone can be increased when it is combined with Aprepitant.
MetronidazoleThe serum concentration of Metronidazole can be increased when it is combined with Aprepitant.
MexiletineThe serum concentration of Mexiletine can be increased when it is combined with Aprepitant.
MexiletineThe metabolism of Aprepitant can be decreased when combined with Mexiletine.
MianserinThe serum concentration of Mianserin can be increased when it is combined with Aprepitant.
MibefradilThe serum concentration of Mibefradil can be increased when it is combined with Aprepitant.
MiconazoleThe serum concentration of Miconazole can be increased when it is combined with Aprepitant.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Aprepitant.
MifepristoneThe serum concentration of Mifepristone can be increased when it is combined with Aprepitant.
MifepristoneThe metabolism of Aprepitant can be decreased when combined with Mifepristone.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Aprepitant.
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Aprepitant.
MitotaneThe serum concentration of Aprepitant can be decreased when it is combined with Mitotane.
MoclobemideThe metabolism of Aprepitant can be decreased when combined with Moclobemide.
ModafinilThe serum concentration of Modafinil can be increased when it is combined with Aprepitant.
ModafinilThe serum concentration of Aprepitant can be decreased when it is combined with Modafinil.
MometasoneThe serum concentration of Mometasone can be increased when it is combined with Aprepitant.
MontelukastThe serum concentration of Montelukast can be increased when it is combined with Aprepitant.
MorphineThe serum concentration of Morphine can be increased when it is combined with Aprepitant.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Aprepitant.
NafcillinThe serum concentration of Aprepitant can be decreased when it is combined with Nafcillin.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Aprepitant.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Aprepitant.
NaproxenThe metabolism of Naproxen can be increased when combined with Aprepitant.
NateglinideThe serum concentration of Nateglinide can be increased when it is combined with Aprepitant.
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Aprepitant.
NefazodoneThe metabolism of Aprepitant can be decreased when combined with Nefazodone.
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Aprepitant.
NelfinavirThe metabolism of Aprepitant can be decreased when combined with Nelfinavir.
NetupitantThe serum concentration of Aprepitant can be increased when it is combined with Netupitant.
NetupitantThe metabolism of Netupitant can be increased when combined with Aprepitant.
NevirapineThe serum concentration of Nevirapine can be increased when it is combined with Aprepitant.
NevirapineThe metabolism of Aprepitant can be decreased when combined with Nevirapine.
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Aprepitant.
NicardipineThe metabolism of Aprepitant can be decreased when combined with Nicardipine.
NiclosamideThe metabolism of Niclosamide can be increased when combined with Aprepitant.
NicotineThe serum concentration of Nicotine can be increased when it is combined with Aprepitant.
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Aprepitant.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Aprepitant.
NilotinibThe metabolism of Aprepitant can be decreased when combined with Nilotinib.
NilvadipineThe serum concentration of Nilvadipine can be increased when it is combined with Aprepitant.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Aprepitant.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Aprepitant.
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Aprepitant.
NitrazepamThe serum concentration of Nitrazepam can be increased when it is combined with Aprepitant.
NitrendipineThe serum concentration of Nitrendipine can be increased when it is combined with Aprepitant.
NorethisteroneThe serum concentration of Norethisterone can be increased when it is combined with Aprepitant.
NorgestrelThe serum concentration of Norgestrel can be increased when it is combined with Aprepitant.
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Aprepitant.
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Aprepitant.
OlaparibThe metabolism of Aprepitant can be decreased when combined with Olaparib.
OlodaterolThe metabolism of Olodaterol can be increased when combined with Aprepitant.
OlopatadineThe serum concentration of Olopatadine can be increased when it is combined with Aprepitant.
OmeprazoleThe serum concentration of Omeprazole can be increased when it is combined with Aprepitant.
OmeprazoleThe metabolism of Aprepitant can be decreased when combined with Omeprazole.
OndansetronThe serum concentration of Ondansetron can be increased when it is combined with Aprepitant.
OrphenadrineThe serum concentration of Orphenadrine can be increased when it is combined with Aprepitant.
OsimertinibThe serum concentration of Aprepitant can be increased when it is combined with Osimertinib.
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Aprepitant.
OxaprozinThe metabolism of Oxaprozin can be increased when combined with Aprepitant.
OxazepamThe serum concentration of Oxazepam can be increased when it is combined with Aprepitant.
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Aprepitant.
OxycodoneThe serum concentration of Oxycodone can be increased when it is combined with Aprepitant.
OxymorphoneThe serum concentration of Oxymorphone can be increased when it is combined with Aprepitant.
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Aprepitant.
PalbociclibThe serum concentration of Palbociclib can be increased when it is combined with Aprepitant.
PalonosetronThe serum concentration of Palonosetron can be increased when it is combined with Aprepitant.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Aprepitant.
PantoprazoleThe serum concentration of Pantoprazole can be increased when it is combined with Aprepitant.
PantoprazoleThe metabolism of Aprepitant can be decreased when combined with Pantoprazole.
ParamethadioneThe serum concentration of Paramethadione can be increased when it is combined with Aprepitant.
ParamethasoneThe serum concentration of Paramethasone can be increased when it is combined with Aprepitant.
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Aprepitant.
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Aprepitant.
ParitaprevirThe serum concentration of Paritaprevir can be increased when it is combined with Aprepitant.
ParoxetineThe serum concentration of Aprepitant can be decreased when it is combined with Paroxetine.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Aprepitant.
Peginterferon alfa-2bThe serum concentration of Aprepitant can be increased when it is combined with Peginterferon alfa-2b.
PentamidineThe serum concentration of Pentamidine can be increased when it is combined with Aprepitant.
PentobarbitalThe metabolism of Aprepitant can be increased when combined with Pentobarbital.
PerampanelThe serum concentration of Perampanel can be increased when it is combined with Aprepitant.
PergolideThe serum concentration of Pergolide can be increased when it is combined with Aprepitant.
PerhexilineThe serum concentration of Perhexiline can be increased when it is combined with Aprepitant.
PermethrinThe serum concentration of Permethrin can be increased when it is combined with Aprepitant.
PerphenazineThe serum concentration of Perphenazine can be increased when it is combined with Aprepitant.
PethidineThe serum concentration of Pethidine can be increased when it is combined with Aprepitant.
PhenacetinThe serum concentration of Phenacetin can be increased when it is combined with Aprepitant.
PhenobarbitalThe metabolism of Aprepitant can be increased when combined with Phenobarbital.
PhenoxybenzamineThe serum concentration of Phenoxybenzamine can be increased when it is combined with Aprepitant.
PhenprocoumonThe serum concentration of Phenprocoumon can be increased when it is combined with Aprepitant.
PhenylbutazoneThe metabolism of Phenylbutazone can be increased when combined with Aprepitant.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Aprepitant.
PhenytoinThe metabolism of Aprepitant can be increased when combined with Phenytoin.
PilocarpineThe serum concentration of Pilocarpine can be increased when it is combined with Aprepitant.
PimecrolimusThe serum concentration of Pimecrolimus can be increased when it is combined with Aprepitant.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Aprepitant.
PinacidilThe serum concentration of Pinacidil can be increased when it is combined with Aprepitant.
PioglitazoneThe serum concentration of Pioglitazone can be increased when it is combined with Aprepitant.
PipotiazineThe serum concentration of Pipotiazine can be increased when it is combined with Aprepitant.
PiroxicamThe metabolism of Piroxicam can be increased when combined with Aprepitant.
PitavastatinThe metabolism of Pitavastatin can be increased when combined with Aprepitant.
PodofiloxThe serum concentration of Podofilox can be increased when it is combined with Aprepitant.
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Aprepitant.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Aprepitant.
PosaconazoleThe serum concentration of Posaconazole can be increased when it is combined with Aprepitant.
PosaconazoleThe metabolism of Aprepitant can be decreased when combined with Posaconazole.
PrasugrelThe serum concentration of Prasugrel can be increased when it is combined with Aprepitant.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Aprepitant.
PrazepamThe serum concentration of Prazepam can be increased when it is combined with Aprepitant.
PraziquantelThe serum concentration of Praziquantel can be increased when it is combined with Aprepitant.
PrednicarbateThe serum concentration of Prednicarbate can be increased when it is combined with Aprepitant.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Aprepitant.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Aprepitant.
PregnenoloneThe serum concentration of Pregnenolone can be increased when it is combined with Aprepitant.
PrimaquineThe serum concentration of Primaquine can be increased when it is combined with Aprepitant.
PrimidoneThe metabolism of Aprepitant can be increased when combined with Primidone.
ProchlorperazineThe serum concentration of Prochlorperazine can be increased when it is combined with Aprepitant.
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Aprepitant.
ProguanilThe serum concentration of Proguanil can be increased when it is combined with Aprepitant.
PromazineThe serum concentration of Promazine can be increased when it is combined with Aprepitant.
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Aprepitant.
PropofolThe serum concentration of Propofol can be increased when it is combined with Aprepitant.
PropranololThe serum concentration of Propranolol can be increased when it is combined with Aprepitant.
PyrazinamideThe serum concentration of Pyrazinamide can be increased when it is combined with Aprepitant.
QuazepamThe serum concentration of Quazepam can be increased when it is combined with Aprepitant.
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Aprepitant.
QuinacrineThe serum concentration of Quinacrine can be increased when it is combined with Aprepitant.
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Aprepitant.
QuinineThe serum concentration of Quinine can be increased when it is combined with Aprepitant.
RabeprazoleThe serum concentration of Rabeprazole can be increased when it is combined with Aprepitant.
RaloxifeneThe serum concentration of Raloxifene can be increased when it is combined with Aprepitant.
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Aprepitant.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Aprepitant.
RanolazineThe metabolism of Aprepitant can be decreased when combined with Ranolazine.
ReboxetineThe serum concentration of Reboxetine can be increased when it is combined with Aprepitant.
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Aprepitant.
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Aprepitant.
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Aprepitant.
RifabutinThe serum concentration of Rifabutin can be increased when it is combined with Aprepitant.
RifabutinThe metabolism of Aprepitant can be increased when combined with Rifabutin.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Aprepitant.
RifampicinThe serum concentration of Aprepitant can be decreased when it is combined with Rifampicin.
RifapentineThe metabolism of Aprepitant can be increased when combined with Rifapentine.
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Aprepitant.
RimexoloneThe serum concentration of Rimexolone can be increased when it is combined with Aprepitant.
RimonabantThe serum concentration of Rimonabant can be increased when it is combined with Aprepitant.
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Aprepitant.
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Aprepitant.
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Aprepitant.
RitonavirThe metabolism of Aprepitant can be decreased when combined with Ritonavir.
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Aprepitant.
RofecoxibThe serum concentration of Rofecoxib can be increased when it is combined with Aprepitant.
RolapitantThe serum concentration of Rolapitant can be increased when it is combined with Aprepitant.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Aprepitant.
RopiniroleThe serum concentration of Ropinirole can be increased when it is combined with Aprepitant.
RopiniroleThe metabolism of Aprepitant can be decreased when combined with Ropinirole.
RopivacaineThe serum concentration of Ropivacaine can be increased when it is combined with Aprepitant.
RosiglitazoneThe metabolism of Rosiglitazone can be increased when combined with Aprepitant.
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Aprepitant.
RotigotineThe serum concentration of Rotigotine can be increased when it is combined with Aprepitant.
RoxithromycinThe serum concentration of Roxithromycin can be increased when it is combined with Aprepitant.
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Aprepitant.
Salicylic acidThe metabolism of Salicylic acid can be increased when combined with Aprepitant.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Aprepitant.
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Aprepitant.
SaquinavirThe metabolism of Aprepitant can be decreased when combined with Saquinavir.
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Aprepitant.
SelegilineThe serum concentration of Selegiline can be increased when it is combined with Aprepitant.
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Aprepitant.
SeratrodastThe serum concentration of Seratrodast can be increased when it is combined with Aprepitant.
SertindoleThe serum concentration of Sertindole can be increased when it is combined with Aprepitant.
SertralineThe serum concentration of Sertraline can be increased when it is combined with Aprepitant.
SertralineThe metabolism of Aprepitant can be decreased when combined with Sertraline.
SevofluraneThe serum concentration of Sevoflurane can be increased when it is combined with Aprepitant.
SibutramineThe serum concentration of Sibutramine can be increased when it is combined with Aprepitant.
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Aprepitant.
SildenafilThe metabolism of Aprepitant can be decreased when combined with Sildenafil.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Aprepitant.
SiltuximabThe serum concentration of Aprepitant can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Aprepitant can be increased when it is combined with Simeprevir.
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Aprepitant.
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Aprepitant.
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Aprepitant.
SitaxentanThe metabolism of Sitaxentan can be increased when combined with Aprepitant.
SolifenacinThe serum concentration of Solifenacin can be increased when it is combined with Aprepitant.
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Aprepitant.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Aprepitant.
SpiramycinThe serum concentration of Spiramycin can be increased when it is combined with Aprepitant.
St. John's WortThe serum concentration of Aprepitant can be decreased when it is combined with St. John's Wort.
StiripentolThe serum concentration of Aprepitant can be increased when it is combined with Stiripentol.
SufentanilThe serum concentration of Sufentanil can be increased when it is combined with Aprepitant.
SulfadiazineThe serum concentration of Sulfadiazine can be increased when it is combined with Aprepitant.
SulfamethoxazoleThe serum concentration of Sulfamethoxazole can be increased when it is combined with Aprepitant.
SulfamoxoleThe metabolism of Sulfamoxole can be increased when combined with Aprepitant.
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be increased when it is combined with Aprepitant.
SulfisoxazoleThe metabolism of Aprepitant can be decreased when combined with Sulfisoxazole.
SunitinibThe serum concentration of Sunitinib can be increased when it is combined with Aprepitant.
SuprofenThe metabolism of Suprofen can be increased when combined with Aprepitant.
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Aprepitant.
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be increased when it is combined with Aprepitant.
Synthetic Conjugated Estrogens, BThe serum concentration of Synthetic Conjugated Estrogens, B can be increased when it is combined with Aprepitant.
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Aprepitant.
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Aprepitant.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Aprepitant.
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Aprepitant.
TapentadolThe metabolism of Tapentadol can be increased when combined with Aprepitant.
TasosartanThe serum concentration of Tasosartan can be increased when it is combined with Aprepitant.
Taurochenodeoxycholic acidThe serum concentration of Taurochenodeoxycholic acid can be increased when it is combined with Aprepitant.
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Aprepitant.
TelaprevirThe metabolism of Aprepitant can be decreased when combined with Telaprevir.
TelithromycinThe serum concentration of Telithromycin can be increased when it is combined with Aprepitant.
TelithromycinThe metabolism of Aprepitant can be decreased when combined with Telithromycin.
TemazepamThe serum concentration of Temazepam can be increased when it is combined with Aprepitant.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Aprepitant.
TeniposideThe serum concentration of Teniposide can be increased when it is combined with Aprepitant.
TenofovirThe metabolism of Aprepitant can be decreased when combined with Tenofovir.
TenoxicamThe metabolism of Tenoxicam can be increased when combined with Aprepitant.
TerbinafineThe serum concentration of Terbinafine can be increased when it is combined with Aprepitant.
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Aprepitant.
TeriflunomideThe serum concentration of Aprepitant can be decreased when it is combined with Teriflunomide.
TesmilifeneThe serum concentration of Tesmilifene can be increased when it is combined with Aprepitant.
TestosteroneThe serum concentration of Testosterone can be increased when it is combined with Aprepitant.
TetracyclineThe serum concentration of Tetracycline can be increased when it is combined with Aprepitant.
ThalidomideThe metabolism of Thalidomide can be increased when combined with Aprepitant.
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Aprepitant.
TheophyllineThe metabolism of Aprepitant can be decreased when combined with Theophylline.
ThiamylalThe metabolism of Thiamylal can be increased when combined with Aprepitant.
ThiotepaThe serum concentration of Thiotepa can be increased when it is combined with Aprepitant.
TiagabineThe serum concentration of Tiagabine can be increased when it is combined with Aprepitant.
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Aprepitant.
TiclopidineThe serum concentration of Ticlopidine can be increased when it is combined with Aprepitant.
TiclopidineThe metabolism of Aprepitant can be decreased when combined with Ticlopidine.
TinidazoleThe serum concentration of Tinidazole can be increased when it is combined with Aprepitant.
TiotropiumThe serum concentration of Tiotropium can be increased when it is combined with Aprepitant.
TipranavirThe serum concentration of Tipranavir can be increased when it is combined with Aprepitant.
TixocortolThe serum concentration of Tixocortol can be increased when it is combined with Aprepitant.
TocilizumabThe serum concentration of Aprepitant can be decreased when it is combined with Tocilizumab.
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Aprepitant.
TolbutamideThe serum concentration of Tolbutamide can be decreased when it is combined with Aprepitant.
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Aprepitant.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Aprepitant.
TopiramateThe metabolism of Aprepitant can be decreased when combined with Topiramate.
TorasemideThe metabolism of Torasemide can be increased when combined with Aprepitant.
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Aprepitant.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Aprepitant.
TramadolThe serum concentration of Tramadol can be increased when it is combined with Aprepitant.
TranylcypromineThe metabolism of Aprepitant can be decreased when combined with Tranylcypromine.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Aprepitant.
TrazodoneThe serum concentration of Trazodone can be increased when it is combined with Aprepitant.
TreprostinilThe metabolism of Treprostinil can be increased when combined with Aprepitant.
TretinoinThe serum concentration of Tretinoin can be increased when it is combined with Aprepitant.
TriamcinoloneThe serum concentration of Triamcinolone can be increased when it is combined with Aprepitant.
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Aprepitant.
TrimethadioneThe serum concentration of Trimethadione can be increased when it is combined with Aprepitant.
TrimethoprimThe serum concentration of Trimethoprim can be increased when it is combined with Aprepitant.
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Aprepitant.
TroglitazoneThe serum concentration of Troglitazone can be increased when it is combined with Aprepitant.
TroleandomycinThe serum concentration of Troleandomycin can be increased when it is combined with Aprepitant.
UdenafilThe serum concentration of Udenafil can be increased when it is combined with Aprepitant.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Aprepitant.
ValdecoxibThe serum concentration of Valdecoxib can be increased when it is combined with Aprepitant.
Valproic AcidThe metabolism of Valproic Acid can be increased when combined with Aprepitant.
ValsartanThe metabolism of Valsartan can be increased when combined with Aprepitant.
VandetanibThe serum concentration of Vandetanib can be increased when it is combined with Aprepitant.
VanoxerineThe serum concentration of Vanoxerine can be increased when it is combined with Aprepitant.
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Aprepitant.
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Aprepitant.
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Aprepitant.
VenlafaxineThe metabolism of Aprepitant can be decreased when combined with Venlafaxine.
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Aprepitant.
VerapamilThe metabolism of Aprepitant can be decreased when combined with Verapamil.
VicrivirocThe serum concentration of Vicriviroc can be increased when it is combined with Aprepitant.
VilanterolThe serum concentration of Vilanterol can be increased when it is combined with Aprepitant.
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Aprepitant.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Aprepitant.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Aprepitant.
VindesineThe serum concentration of Vindesine can be increased when it is combined with Aprepitant.
VinorelbineThe serum concentration of Vinorelbine can be increased when it is combined with Aprepitant.
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Aprepitant.
VoriconazoleThe serum concentration of Voriconazole can be increased when it is combined with Aprepitant.
VoriconazoleThe metabolism of Aprepitant can be decreased when combined with Voriconazole.
VortioxetineThe serum concentration of Vortioxetine can be increased when it is combined with Aprepitant.
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Aprepitant.
XimelagatranThe metabolism of Ximelagatran can be increased when combined with Aprepitant.
YohimbineThe serum concentration of Yohimbine can be increased when it is combined with Aprepitant.
ZafirlukastThe serum concentration of Zafirlukast can be increased when it is combined with Aprepitant.
ZalcitabineThe serum concentration of Zalcitabine can be increased when it is combined with Aprepitant.
ZaleplonThe serum concentration of Zaleplon can be increased when it is combined with Aprepitant.
ZaltoprofenThe metabolism of Zaltoprofen can be increased when combined with Aprepitant.
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Aprepitant.
ZileutonThe serum concentration of Zileuton can be increased when it is combined with Aprepitant.
ZiprasidoneThe serum concentration of Ziprasidone can be increased when it is combined with Aprepitant.
ZiprasidoneThe metabolism of Aprepitant can be decreased when combined with Ziprasidone.
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Aprepitant.
ZomepiracThe serum concentration of Zomepirac can be increased when it is combined with Aprepitant.
ZonisamideThe serum concentration of Zonisamide can be increased when it is combined with Aprepitant.
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Aprepitant.
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Aprepitant.
Food Interactions
  • Take without regard to meals.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Tachykinin receptor activity
Specific Function:
This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.
Gene Name:
TACR1
Uniprot ID:
P25103
Molecular Weight:
46250.5 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Brands KM, Payack JF, Rosen JD, Nelson TD, Candelario A, Huffman MA, Zhao MM, Li J, Craig B, Song ZJ, Tschaen DM, Hansen K, Devine PN, Pye PJ, Rossen K, Dormer PG, Reamer RA, Welch CJ, Mathre DJ, Tsou NN, McNamara JM, Reider PJ: Efficient synthesis of NK(1) receptor antagonist aprepitant using a crystallization-induced diastereoselective transformation. J Am Chem Soc. 2003 Feb 26;125(8):2129-35. [PubMed:12590540 ]
  3. Rodgers J, Bradley B, Kennedy PG: Combination chemotherapy with a substance P receptor antagonist (aprepitant) and melarsoprol in a mouse model of human African trypanosomiasis. Parasitol Int. 2007 Dec;56(4):321-4. Epub 2007 Jun 29. [PubMed:17643344 ]
  4. Poli-Bigelli S, Rodrigues-Pereira J, Carides AD, Julie Ma G, Eldridge K, Hipple A, Evans JK, Horgan KJ, Lawson F: Addition of the neurokinin 1 receptor antagonist aprepitant to standard antiemetic therapy improves control of chemotherapy-induced nausea and vomiting. Results from a randomized, double-blind, placebo-controlled trial in Latin America. Cancer. 2003 Jun 15;97(12):3090-8. [PubMed:12784346 ]
  5. Zhao MM, McNamara JM, Ho GJ, Emerson KM, Song ZJ, Tschaen DM, Brands KM, Dolling UH, Grabowski EJ, Reider PJ, Cottrell IF, Ashwood MS, Bishop BC: Practical asymmetric synthesis of aprepitant, a potent human NK-1 receptor antagonist, via a stereoselective Lewis acid-catalyzed trans acetalization reaction. J Org Chem. 2002 Sep 20;67(19):6743-7. [PubMed:12227806 ]
  6. Bergstrom M, Hargreaves RJ, Burns HD, Goldberg MR, Sciberras D, Reines SA, Petty KJ, Ogren M, Antoni G, Langstrom B, Eskola O, Scheinin M, Solin O, Majumdar AK, Constanzer ML, Battisti WP, Bradstreet TE, Gargano C, Hietala J: Human positron emission tomography studies of brain neurokinin 1 receptor occupancy by aprepitant. Biol Psychiatry. 2004 May 15;55(10):1007-12. [PubMed:15121485 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Sanchez RI, Wang RW, Newton DJ, Bakhtiar R, Lu P, Chiu SH, Evans DC, Huskey SE: Cytochrome P450 3A4 is the major enzyme involved in the metabolism of the substance P receptor antagonist aprepitant. Drug Metab Dispos. 2004 Nov;32(11):1287-92. Epub 2004 Aug 10. [PubMed:15304427 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Sanchez RI, Wang RW, Newton DJ, Bakhtiar R, Lu P, Chiu SH, Evans DC, Huskey SE: Cytochrome P450 3A4 is the major enzyme involved in the metabolism of the substance P receptor antagonist aprepitant. Drug Metab Dispos. 2004 Nov;32(11):1287-92. Epub 2004 Aug 10. [PubMed:15304427 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Sanchez RI, Wang RW, Newton DJ, Bakhtiar R, Lu P, Chiu SH, Evans DC, Huskey SE: Cytochrome P450 3A4 is the major enzyme involved in the metabolism of the substance P receptor antagonist aprepitant. Drug Metab Dispos. 2004 Nov;32(11):1287-92. Epub 2004 Aug 10. [PubMed:15304427 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
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Drug created on June 13, 2005 07:24 / Updated on September 25, 2016 02:15