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Identification
NameBoceprevir
Accession NumberDB08873
TypeSmall Molecule
GroupsApproved
DescriptionBoceprevir is a direct acting protease inhibitor for the treatment of hepatitis C. It also has two isomers in which the S isomer is more active than the R-isomer. FDA approved on May 13, 2011.
Structure
Thumb
Synonyms
SCH 503034
Victrelis
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Victreliscapsule200 mg/1oralMerck Sharp & Dohme Corp.2011-05-13Not applicableUs
Victreliscapsule200 mgoralMerck Canada Inc2011-08-02Not applicableCanada
VictrelisCapsule, hard200 mgOral useMerck Sharp & Dohme Ltd2011-07-18Not applicableEu
VictrelisCapsule, hard200 mgOral useMerck Sharp & Dohme Ltd2011-07-18Not applicableEu
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
Victrelis TripleMerck Canada Inc
SaltsNot Available
Categories
UNII89BT58KELH
CAS number394730-60-0
WeightAverage: 519.6767
Monoisotopic: 519.342069575
Chemical FormulaC27H45N5O5
InChI KeyInChIKey=LHHCSNFAOIFYRV-DOVBMPENSA-N
InChI
InChI=1S/C27H45N5O5/c1-25(2,3)20(30-24(37)31-26(4,5)6)23(36)32-13-15-17(27(15,7)8)18(32)22(35)29-16(19(33)21(28)34)12-14-10-9-11-14/h14-18,20H,9-13H2,1-8H3,(H2,28,34)(H,29,35)(H2,30,31,37)/t15-,16?,17-,18-,20+/m0/s1
IUPAC Name
3-{[(1R,2S,5S)-3-[(2S)-2-[(tert-butylcarbamoyl)amino]-3,3-dimethylbutanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2-yl]formamido}-4-cyclobutyl-2-oxobutanamide
SMILES
[H][C@]12CN([[email protected]](C(=O)NC(CC3CCC3)C(=O)C(N)=O)[C@@]1([H])C2(C)C)C(=O)[C@@H](NC(=O)NC(C)(C)C)C(C)(C)C
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as hybrid peptides. These are compounds containing at least two different types of amino acids (alpha, beta, gamma, delta) linked to each other through a peptide bond.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentHybrid peptides
Alternative Parents
Substituents
  • Hybrid peptide
  • N-carbamoyl-alpha-amino acid or derivatives
  • Alpha-amino acid amide
  • Piperidinecarboxylic acid
  • Piperidinecarboxamide
  • 2-piperidinecarboxamide
  • N-acyl-piperidine
  • Pyrrolidine-2-carboxamide
  • Pyrrolidine carboxylic acid or derivatives
  • N-acylpyrrolidine
  • Fatty acyl
  • Piperidine
  • Fatty amide
  • Tertiary carboxylic acid amide
  • Pyrrolidine
  • Alpha-aminoketone
  • Urea
  • Tertiary amine
  • Secondary carboxylic acid amide
  • Primary carboxylic acid amide
  • Ketone
  • Carboxamide group
  • Azacycle
  • Organoheterocyclic compound
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aliphatic heteropolycyclic compound
Molecular FrameworkAliphatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationTreatment of chronic hepatitis C genotype 1 in patients that have a compensated liver (as a result of liver diseases like cirrhosis) and are previously untreated or therapy with peginterferon alfa and ribavirin has failed.
PharmacodynamicsTelaprevir is a direct-acting antiviral agent (DAA) against the hepatitis C virus.
Mechanism of actionBoceprevir inhibits replication of the hepatitis C virus by binding reversibly to nonstructural protein 3/4a (NS3 and NS4A respectively) serine protease. NS4A is a cofactor that works with NS3 for viral replication.
Related Articles
AbsorptionFood increases exposure of boceprevir by up to 65% relative to fasting state. However, type of food and time of meal does not affect bioavailability of boceprevir and thus can be taken without regards to food. Tmax = 2 hours; Time to steady state, three times a day dosing = 1 day; Cmax, 400 mg single dose, healthy subject = 557 ng/mL; AUC ∞, healthy subject = 2020 ng · h/mL;
Volume of distribution

~722 L

Protein binding~75%
Metabolism

Hepatically metabolized by the aldo-ketoreductase pathway into inactive metabolites via reduction. To a lesser extent, CYP3A4 and CYP3A5 is also involved in the metabolism of boceprevir (oxidative process).

Route of eliminationRemoved via feces (79%) and urine (9%) which suggest some degree of hepatic excretion.
Half lifeMean plasma half-life = 3.4 hours
Clearance

Mean total body clearance (Cl/F) = 161 L/h

ToxicityNot Available
Affected organisms
  • Hepatitis C virus, RSV and other RNA/DNA viruses
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.6781
Blood Brain Barrier-0.8805
Caco-2 permeable-0.6532
P-glycoprotein substrateSubstrate0.8394
P-glycoprotein inhibitor IInhibitor0.671
P-glycoprotein inhibitor IIInhibitor0.6377
Renal organic cation transporterNon-inhibitor0.8188
CYP450 2C9 substrateNon-substrate0.7965
CYP450 2D6 substrateNon-substrate0.7996
CYP450 3A4 substrateSubstrate0.621
CYP450 1A2 substrateNon-inhibitor0.7987
CYP450 2C9 inhibitorNon-inhibitor0.7265
CYP450 2D6 inhibitorNon-inhibitor0.87
CYP450 2C19 inhibitorNon-inhibitor0.6908
CYP450 3A4 inhibitorNon-inhibitor0.9659
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8434
Ames testNon AMES toxic0.662
CarcinogenicityNon-carcinogens0.8555
BiodegradationReady biodegradable0.5913
Rat acute toxicity2.6263 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9828
hERG inhibition (predictor II)Non-inhibitor0.7092
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
Capsuleoral200 mg/1
Capsuleoral200 mg
Capsule, hardOral use200 mg
Capsule; powder for solutionoral; subcutaneous
PricesNot Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US7772178 No2007-11-112027-11-11Us
US8119602 No2007-03-172027-03-17Us
USRE43298 No2002-02-222022-02-22Us
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.0234 mg/mLALOGPS
logP1.93ALOGPS
logP1.78ChemAxon
logS-4.3ALOGPS
pKa (Strongest Acidic)12.44ChemAxon
pKa (Strongest Basic)-0.91ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area150.7 Å2ChemAxon
Rotatable Bond Count10ChemAxon
Refractivity138.2 m3·mol-1ChemAxon
Polarizability56.78 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

James Lalonde, Tao Li, Jack Liang, Benjamin Mijts, Roger Sheldon, George S.K. Wong, Aleksey Zaks, “Substantially Stereomerically Pure Fused Bicyclic Proline Compounds and Processes for Preparing Boceprevir.” U.S. Patent US20120289709, issued November 15, 2012.

US20120289709
General References
  1. Kiser JJ, Flexner C: Direct-acting antiviral agents for hepatitis C virus infection. Annu Rev Pharmacol Toxicol. 2013;53:427-49. doi: 10.1146/annurev-pharmtox-011112-140254. Epub 2012 Nov 5. [PubMed:23140245 ]
  2. Treitel M, Marbury T, Preston RA, Triantafyllou I, Feely W, O'Mara E, Kasserra C, Gupta S, Hughes EA: Single-dose pharmacokinetics of boceprevir in subjects with impaired hepatic or renal function. Clin Pharmacokinet. 2012 Sep 1;51(9):619-28. doi: 10.2165/11633440-000000000-00000. [PubMed:22799589 ]
  3. Wilby KJ, Partovi N, Ford JA, Greanya E, Yoshida EM: Review of boceprevir and telaprevir for the treatment of chronic hepatitis C. Can J Gastroenterol. 2012 Apr;26(4):205-10. [PubMed:22506260 ]
External Links
ATC CodesJ05AE12
AHFS Codes
  • 8:18.40
PDB EntriesNot Available
FDA labelDownload (710 KB)
MSDSNot Available
Interactions
Drug Interactions
Drug
1,10-PhenanthrolineThe serum concentration of 1,10-Phenanthroline can be decreased when it is combined with Boceprevir.
3,4-DichloroisocoumarinThe serum concentration of 3,4-Dichloroisocoumarin can be decreased when it is combined with Boceprevir.
4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDEThe serum concentration of 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE can be decreased when it is combined with Boceprevir.
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be increased when it is combined with Boceprevir.
AbacavirThe serum concentration of Abacavir can be decreased when it is combined with Boceprevir.
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Boceprevir.
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Boceprevir.
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Boceprevir.
AcetaminophenThe serum concentration of Boceprevir can be increased when it is combined with Acetaminophen.
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Boceprevir.
AfatinibThe serum concentration of Boceprevir can be increased when it is combined with Afatinib.
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Boceprevir.
AlbendazoleThe serum concentration of Boceprevir can be increased when it is combined with Albendazole.
AlclometasoneThe serum concentration of Alclometasone can be increased when it is combined with Boceprevir.
AldosteroneThe serum concentration of Boceprevir can be decreased when it is combined with Aldosterone.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Boceprevir.
AlectinibThe serum concentration of Boceprevir can be increased when it is combined with Alectinib.
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Boceprevir.
AlfentanilThe serum concentration of Boceprevir can be increased when it is combined with Alfentanil.
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Boceprevir.
AliskirenThe metabolism of Aliskiren can be decreased when combined with Boceprevir.
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Boceprevir.
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Boceprevir.
AlogliptinThe serum concentration of Alogliptin can be decreased when it is combined with Boceprevir.
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Boceprevir.
Alpha-1-proteinase inhibitorThe serum concentration of Alpha-1-proteinase inhibitor can be decreased when it is combined with Boceprevir.
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Boceprevir.
AmantadineThe serum concentration of Boceprevir can be increased when it is combined with Amantadine.
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Boceprevir.
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Boceprevir.
AmcinonideThe serum concentration of Amcinonide can be increased when it is combined with Boceprevir.
AmineptineThe serum concentration of Amineptine can be increased when it is combined with Boceprevir.
Aminohippuric acidThe serum concentration of Boceprevir can be increased when it is combined with Aminohippuric acid.
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Boceprevir.
AminophyllineThe serum concentration of Aminophylline can be decreased when it is combined with Boceprevir.
AmiodaroneThe serum concentration of Amiodarone can be increased when it is combined with Boceprevir.
AmiodaroneThe serum concentration of Boceprevir can be decreased when it is combined with Amiodarone.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Boceprevir.
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Boceprevir.
AmlodipineThe serum concentration of Boceprevir can be increased when it is combined with Amlodipine.
AmprenavirThe serum concentration of Amprenavir can be decreased when it is combined with Boceprevir.
AmsacrineThe serum concentration of Boceprevir can be increased when it is combined with Amsacrine.
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Boceprevir.
Antithrombin III humanThe serum concentration of Antithrombin III human can be decreased when it is combined with Boceprevir.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Boceprevir.
ApremilastThe metabolism of Apremilast can be decreased when combined with Boceprevir.
AprepitantThe serum concentration of Boceprevir can be increased when it is combined with Aprepitant.
AprepitantThe metabolism of Aprepitant can be decreased when combined with Boceprevir.
AprotininThe serum concentration of Aprotinin can be decreased when it is combined with Boceprevir.
ArgatrobanThe serum concentration of Argatroban can be decreased when it is combined with Boceprevir.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Boceprevir.
ArtemetherThe metabolism of Artemether can be decreased when combined with Boceprevir.
AsenapineThe metabolism of Asenapine can be decreased when combined with Boceprevir.
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Boceprevir.
AsunaprevirThe serum concentration of Asunaprevir can be decreased when it is combined with Boceprevir.
AtazanavirThe serum concentration of Atazanavir can be decreased when it is combined with Boceprevir.
AtazanavirThe serum concentration of Boceprevir can be increased when it is combined with Atazanavir.
AtenololThe serum concentration of Boceprevir can be increased when it is combined with Atenolol.
AtomoxetineThe metabolism of Boceprevir can be decreased when combined with Atomoxetine.
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Boceprevir.
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Boceprevir.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Boceprevir.
AzelastineThe metabolism of Azelastine can be decreased when combined with Boceprevir.
AzelastineThe serum concentration of Boceprevir can be increased when it is combined with Azelastine.
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Boceprevir.
AzithromycinThe serum concentration of Boceprevir can be increased when it is combined with Azithromycin.
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Boceprevir.
BarnidipineThe serum concentration of Barnidipine can be increased when it is combined with Boceprevir.
BatimastatThe serum concentration of Batimastat can be decreased when it is combined with Boceprevir.
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be increased when it is combined with Boceprevir.
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Boceprevir.
BenazeprilThe serum concentration of Benazepril can be decreased when it is combined with Boceprevir.
BenzamidineThe serum concentration of Benzamidine can be decreased when it is combined with Boceprevir.
BenzocaineThe serum concentration of Boceprevir can be increased when it is combined with Benzocaine.
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Boceprevir.
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Boceprevir.
BepridilThe serum concentration of Bepridil can be increased when it is combined with Boceprevir.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Boceprevir.
BexaroteneThe serum concentration of Boceprevir can be decreased when it is combined with Bexarotene.
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Boceprevir.
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Boceprevir.
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Boceprevir.
BiperidenThe serum concentration of Boceprevir can be increased when it is combined with Biperiden.
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Boceprevir.
BivalirudinThe serum concentration of Bivalirudin can be decreased when it is combined with Boceprevir.
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Boceprevir.
BortezomibThe metabolism of Boceprevir can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Boceprevir can be decreased when it is combined with Bosentan.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Boceprevir.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Boceprevir.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Boceprevir.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Boceprevir.
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Boceprevir.
BromazepamThe metabolism of Bromazepam can be decreased when combined with Boceprevir.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Boceprevir.
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Boceprevir.
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Boceprevir.
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Boceprevir.
BuprenorphineThe serum concentration of Buprenorphine can be decreased when it is combined with Boceprevir.
BuprenorphineThe serum concentration of Boceprevir can be increased when it is combined with Buprenorphine.
BupropionThe metabolism of Bupropion can be decreased when combined with Boceprevir.
BuspironeThe metabolism of Buspirone can be decreased when combined with Boceprevir.
BuspironeThe serum concentration of Boceprevir can be increased when it is combined with Buspirone.
BusulfanThe metabolism of Busulfan can be decreased when combined with Boceprevir.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Boceprevir.
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Boceprevir.
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Boceprevir.
CaffeineThe metabolism of Caffeine can be decreased when combined with Boceprevir.
CaffeineThe serum concentration of Boceprevir can be increased when it is combined with Caffeine.
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Boceprevir.
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Boceprevir.
CanagliflozinThe serum concentration of Boceprevir can be increased when it is combined with Canagliflozin.
CandesartanThe serum concentration of Boceprevir can be increased when it is combined with Candesartan.
CandoxatrilThe serum concentration of Candoxatril can be decreased when it is combined with Boceprevir.
CaptoprilThe serum concentration of Captopril can be decreased when it is combined with Boceprevir.
CaptoprilThe serum concentration of Boceprevir can be increased when it is combined with Captopril.
CarbamazepineThe serum concentration of Boceprevir can be decreased when it is combined with Carbamazepine.
CarbamazepineThe metabolism of Carbamazepine can be decreased when combined with Boceprevir.
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Boceprevir.
CariprazineThe metabolism of Cariprazine can be decreased when combined with Boceprevir.
CarvedilolThe metabolism of Carvedilol can be decreased when combined with Boceprevir.
CarvedilolThe serum concentration of Boceprevir can be increased when it is combined with Carvedilol.
CaspofunginThe serum concentration of Boceprevir can be increased when it is combined with Caspofungin.
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Boceprevir.
CeliprololThe metabolism of Celiprolol can be decreased when combined with Boceprevir.
CephalexinThe metabolism of Cephalexin can be decreased when combined with Boceprevir.
CeritinibThe serum concentration of Boceprevir can be increased when it is combined with Ceritinib.
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Boceprevir.
CevimelineThe metabolism of Cevimeline can be decreased when combined with Boceprevir.
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Boceprevir.
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Boceprevir.
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Boceprevir.
ChloroquineThe serum concentration of Boceprevir can be increased when it is combined with Chloroquine.
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Boceprevir.
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Boceprevir.
ChlorpromazineThe serum concentration of Boceprevir can be increased when it is combined with Chlorpromazine.
ChlorpropamideThe serum concentration of Boceprevir can be increased when it is combined with Chlorpropamide.
ChlorprothixeneThe serum concentration of Boceprevir can be increased when it is combined with Chlorprothixene.
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Boceprevir.
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Boceprevir.
CholesterolThe serum concentration of Boceprevir can be increased when it is combined with Cholesterol.
Cholic AcidThe serum concentration of Boceprevir can be decreased when it is combined with Cholic Acid.
ChymostatinThe serum concentration of Chymostatin can be decreased when it is combined with Boceprevir.
CiclesonideThe serum concentration of Ciclesonide can be increased when it is combined with Boceprevir.
CilastatinThe serum concentration of Cilastatin can be decreased when it is combined with Boceprevir.
CilazaprilThe serum concentration of Cilazapril can be decreased when it is combined with Boceprevir.
CilazaprilThe serum concentration of Boceprevir can be increased when it is combined with Cilazapril.
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Boceprevir.
CimetidineThe serum concentration of Boceprevir can be decreased when it is combined with Cimetidine.
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Boceprevir.
CiprofloxacinThe serum concentration of Boceprevir can be increased when it is combined with Ciprofloxacin.
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Boceprevir.
CitalopramThe metabolism of Citalopram can be decreased when combined with Boceprevir.
CitalopramThe serum concentration of Boceprevir can be increased when it is combined with Citalopram.
ClarithromycinThe therapeutic efficacy of Clarithromycin can be decreased when used in combination with Boceprevir.
ClarithromycinThe serum concentration of Boceprevir can be increased when it is combined with Clarithromycin.
ClemastineThe metabolism of Boceprevir can be decreased when combined with Clemastine.
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Boceprevir.
ClobazamThe metabolism of Clobazam can be decreased when combined with Boceprevir.
Clobetasol propionateThe serum concentration of Clobetasol propionate can be increased when it is combined with Boceprevir.
ClocortoloneThe serum concentration of Clocortolone can be increased when it is combined with Boceprevir.
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Boceprevir.
ClofazimineThe serum concentration of Boceprevir can be increased when it is combined with Clofazimine.
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Boceprevir.
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Boceprevir.
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Boceprevir.
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Boceprevir.
ClonidineThe metabolism of Clonidine can be decreased when combined with Boceprevir.
ClopidogrelThe metabolism of Clopidogrel can be decreased when combined with Boceprevir.
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Boceprevir.
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Boceprevir.
ClotrimazoleThe metabolism of Boceprevir can be decreased when combined with Clotrimazole.
ClozapineThe metabolism of Clozapine can be decreased when combined with Boceprevir.
CobicistatThe serum concentration of Boceprevir can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Boceprevir.
CocaineThe metabolism of Cocaine can be decreased when combined with Boceprevir.
CodeineThe metabolism of Codeine can be decreased when combined with Boceprevir.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Boceprevir.
ColforsinThe serum concentration of Boceprevir can be increased when it is combined with Colforsin.
ConivaptanThe serum concentration of Boceprevir can be increased when it is combined with Conivaptan.
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be decreased when combined with Boceprevir.
Cortisone acetateThe serum concentration of Cortisone acetate can be increased when it is combined with Boceprevir.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Boceprevir.
CrizotinibThe metabolism of Boceprevir can be decreased when combined with Crizotinib.
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Boceprevir.
CyclophosphamideThe risk or severity of adverse effects can be increased when Boceprevir is combined with Cyclophosphamide.
CyclophosphamideThe serum concentration of Boceprevir can be increased when it is combined with Cyclophosphamide.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Boceprevir.
CyclosporineThe metabolism of Boceprevir can be decreased when combined with Cyclosporine.
CytarabineThe metabolism of Cytarabine can be decreased when combined with Boceprevir.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be decreased when it is combined with Boceprevir.
DabrafenibThe serum concentration of Boceprevir can be decreased when it is combined with Dabrafenib.
DabrafenibThe metabolism of Dabrafenib can be decreased when combined with Boceprevir.
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Boceprevir.
DactinomycinThe serum concentration of Boceprevir can be increased when it is combined with Dactinomycin.
DantroleneThe metabolism of Dantrolene can be decreased when combined with Boceprevir.
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Boceprevir.
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Boceprevir.
DapsoneThe metabolism of Dapsone can be decreased when combined with Boceprevir.
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Boceprevir.
DarunavirThe serum concentration of Darunavir can be decreased when it is combined with Boceprevir.
DarunavirThe metabolism of Boceprevir can be decreased when combined with Darunavir.
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Boceprevir.
DasatinibThe serum concentration of Boceprevir can be increased when it is combined with Dasatinib.
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Boceprevir.
DaunorubicinThe serum concentration of Boceprevir can be decreased when it is combined with Daunorubicin.
DeferasiroxThe serum concentration of Boceprevir can be decreased when it is combined with Deferasirox.
DehydroepiandrosteroneThe serum concentration of Dehydroepiandrosterone can be increased when it is combined with Boceprevir.
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be increased when it is combined with Boceprevir.
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Boceprevir.
DelavirdineThe metabolism of Boceprevir can be decreased when combined with Delavirdine.
DesipramineThe serum concentration of Desipramine can be increased when it is combined with Boceprevir.
DesloratadineThe serum concentration of Boceprevir can be increased when it is combined with Desloratadine.
DesoximetasoneThe serum concentration of Desoximetasone can be increased when it is combined with Boceprevir.
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be increased when it is combined with Boceprevir.
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Boceprevir.
DexamethasoneThe serum concentration of Boceprevir can be decreased when it is combined with Dexamethasone.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Boceprevir.
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Boceprevir.
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Boceprevir.
DextromethorphanThe serum concentration of Boceprevir can be increased when it is combined with Dextromethorphan.
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Boceprevir.
DiazepamThe metabolism of Diazepam can be decreased when combined with Boceprevir.
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Boceprevir.
DiclofenacThe serum concentration of Boceprevir can be increased when it is combined with Diclofenac.
DienogestThe serum concentration of Dienogest can be increased when it is combined with Boceprevir.
DiflorasoneThe serum concentration of Diflorasone can be increased when it is combined with Boceprevir.
DifluocortoloneThe serum concentration of Difluocortolone can be increased when it is combined with Boceprevir.
DifluprednateThe serum concentration of Difluprednate can be increased when it is combined with Boceprevir.
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Boceprevir.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Boceprevir.
DigoxinThe serum concentration of Boceprevir can be decreased when it is combined with Digoxin.
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Boceprevir.
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Boceprevir.
DihydroergotamineThe metabolism of Boceprevir can be decreased when combined with Dihydroergotamine.
DiltiazemThe metabolism of Boceprevir can be decreased when combined with Diltiazem.
DipyridamoleThe serum concentration of Boceprevir can be increased when it is combined with Dipyridamole.
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Boceprevir.
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Boceprevir.
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Boceprevir.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Boceprevir.
DolasetronThe metabolism of Dolasetron can be decreased when combined with Boceprevir.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Boceprevir.
DonepezilThe metabolism of Donepezil can be decreased when combined with Boceprevir.
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Boceprevir.
DosulepinThe serum concentration of Dosulepin can be increased when it is combined with Boceprevir.
DoxazosinThe serum concentration of Doxazosin can be increased when it is combined with Boceprevir.
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Boceprevir.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Boceprevir.
DoxorubicinThe serum concentration of Boceprevir can be decreased when it is combined with Doxorubicin.
DoxycyclineThe metabolism of Boceprevir can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Boceprevir.
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Boceprevir.
DronedaroneThe metabolism of Boceprevir can be decreased when combined with Dronedarone.
DrospirenoneThe serum concentration of Drospirenone can be increased when it is combined with Boceprevir.
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Boceprevir.
DyphyllineThe serum concentration of Dyphylline can be decreased when it is combined with Boceprevir.
EcabetThe serum concentration of Ecabet can be decreased when it is combined with Boceprevir.
EdoxabanThe serum concentration of Edoxaban can be decreased when it is combined with Boceprevir.
EfavirenzThe serum concentration of Boceprevir can be decreased when it is combined with Efavirenz.
EfavirenzThe metabolism of Efavirenz can be decreased when combined with Boceprevir.
ElafinThe serum concentration of Elafin can be decreased when it is combined with Boceprevir.
ElbasvirThe serum concentration of Boceprevir can be increased when it is combined with Elbasvir.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Boceprevir.
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Boceprevir.
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Boceprevir.
EnalaprilThe serum concentration of Enalapril can be decreased when it is combined with Boceprevir.
EnalaprilThe serum concentration of Boceprevir can be increased when it is combined with Enalapril.
EnalaprilatThe serum concentration of Enalaprilat can be decreased when it is combined with Boceprevir.
EnalkirenThe serum concentration of Enalkiren can be decreased when it is combined with Boceprevir.
EnfuvirtideThe serum concentration of Enfuvirtide can be increased when it is combined with Boceprevir.
EnzalutamideThe serum concentration of Enzalutamide can be increased when it is combined with Boceprevir.
EnzalutamideThe serum concentration of Boceprevir can be decreased when it is combined with Enzalutamide.
EpinastineThe metabolism of Epinastine can be decreased when combined with Boceprevir.
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Boceprevir.
EquileninThe serum concentration of Equilenin can be increased when it is combined with Boceprevir.
EquilinThe serum concentration of Equilin can be increased when it is combined with Boceprevir.
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Boceprevir.
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Boceprevir.
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Boceprevir.
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Boceprevir.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Boceprevir.
ErythromycinThe metabolism of Boceprevir can be decreased when combined with Erythromycin.
EscitalopramThe serum concentration of Escitalopram can be decreased when it is combined with Boceprevir.
Eslicarbazepine acetateThe serum concentration of Boceprevir can be decreased when it is combined with Eslicarbazepine acetate.
EsmirtazapineThe serum concentration of Esmirtazapine can be increased when it is combined with Boceprevir.
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Boceprevir.
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Boceprevir.
EstradiolThe metabolism of Estradiol can be decreased when combined with Boceprevir.
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Boceprevir.
EstramustineThe metabolism of Estramustine can be decreased when combined with Boceprevir.
EstramustineThe serum concentration of Boceprevir can be increased when it is combined with Estramustine.
EstriolThe serum concentration of Boceprevir can be decreased when it is combined with Estriol.
EstroneThe serum concentration of Boceprevir can be decreased when it is combined with Estrone.
EstroneThe serum concentration of Estrone can be increased when it is combined with Boceprevir.
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Boceprevir.
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Boceprevir.
EthanolThe metabolism of Ethanol can be decreased when combined with Boceprevir.
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Boceprevir.
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Boceprevir.
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Boceprevir.
EtizolamThe serum concentration of Etizolam can be increased when it is combined with Boceprevir.
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Boceprevir.
EtoposideThe metabolism of Etoposide can be decreased when combined with Boceprevir.
EtoposideThe serum concentration of Boceprevir can be increased when it is combined with Etoposide.
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Boceprevir.
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Boceprevir.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Boceprevir.
ExemestaneThe metabolism of Exemestane can be decreased when combined with Boceprevir.
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Boceprevir.
FelbamateThe metabolism of Felbamate can be decreased when combined with Boceprevir.
FelodipineThe metabolism of Felodipine can be decreased when combined with Boceprevir.
FelodipineThe serum concentration of Boceprevir can be increased when it is combined with Felodipine.
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Boceprevir.
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Boceprevir.
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Boceprevir.
FexofenadineThe serum concentration of Boceprevir can be increased when it is combined with Fexofenadine.
FidaxomicinThe serum concentration of Boceprevir can be increased when it is combined with Fidaxomicin.
FinasterideThe metabolism of Finasteride can be decreased when combined with Boceprevir.
FingolimodThe metabolism of Fingolimod can be decreased when combined with Boceprevir.
FlecainideThe serum concentration of Flecainide can be increased when it is combined with Boceprevir.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Boceprevir.
FluconazoleThe metabolism of Boceprevir can be decreased when combined with Fluconazole.
FludrocortisoneThe serum concentration of Fludrocortisone can be increased when it is combined with Boceprevir.
FlumethasoneThe serum concentration of Flumethasone can be increased when it is combined with Boceprevir.
FlunisolideThe serum concentration of Flunisolide can be increased when it is combined with Boceprevir.
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Boceprevir.
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be increased when it is combined with Boceprevir.
FluocinonideThe serum concentration of Fluocinonide can be increased when it is combined with Boceprevir.
FluocortoloneThe serum concentration of Fluocortolone can be increased when it is combined with Boceprevir.
FluorometholoneThe serum concentration of Fluorometholone can be increased when it is combined with Boceprevir.
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Boceprevir.
FluoxetineThe serum concentration of Boceprevir can be increased when it is combined with Fluoxetine.
FlupentixolThe serum concentration of Boceprevir can be increased when it is combined with Flupentixol.
FluphenazineThe serum concentration of Boceprevir can be increased when it is combined with Fluphenazine.
FluprednideneThe serum concentration of Fluprednidene can be increased when it is combined with Boceprevir.
FluprednisoloneThe serum concentration of Fluprednisolone can be increased when it is combined with Boceprevir.
FlurandrenolideThe serum concentration of Flurandrenolide can be increased when it is combined with Boceprevir.
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Boceprevir.
FlurazepamThe serum concentration of Boceprevir can be increased when it is combined with Flurazepam.
FlutamideThe metabolism of Flutamide can be decreased when combined with Boceprevir.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Boceprevir.
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Boceprevir.
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Boceprevir.
FluvoxamineThe metabolism of Boceprevir can be decreased when combined with Fluvoxamine.
FosamprenavirThe serum concentration of Fosamprenavir can be decreased when it is combined with Boceprevir.
FosamprenavirThe metabolism of Boceprevir can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Boceprevir can be increased when it is combined with Fosaprepitant.
FosinoprilThe serum concentration of Fosinopril can be decreased when it is combined with Boceprevir.
FosphenytoinThe serum concentration of Boceprevir can be decreased when it is combined with Fosphenytoin.
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Boceprevir.
Fusidic AcidThe serum concentration of Boceprevir can be increased when it is combined with Fusidic Acid.
GalantamineThe metabolism of Galantamine can be decreased when combined with Boceprevir.
GarlicThe serum concentration of Boceprevir can be decreased when it is combined with Garlic.
GefitinibThe metabolism of Gefitinib can be decreased when combined with Boceprevir.
GefitinibThe serum concentration of Boceprevir can be increased when it is combined with Gefitinib.
GeldanamycinThe serum concentration of Geldanamycin can be decreased when it is combined with Boceprevir.
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Boceprevir.
GenisteinThe serum concentration of Boceprevir can be increased when it is combined with Genistein.
GlipizideThe metabolism of Glipizide can be decreased when combined with Boceprevir.
GlyburideThe metabolism of Glyburide can be decreased when combined with Boceprevir.
GlyburideThe serum concentration of Boceprevir can be increased when it is combined with Glyburide.
GlycerolThe serum concentration of Boceprevir can be increased when it is combined with Glycerol.
GM6001The serum concentration of GM6001 can be decreased when it is combined with Boceprevir.
Gramicidin DThe serum concentration of Boceprevir can be increased when it is combined with Gramicidin D.
GranisetronThe metabolism of Granisetron can be decreased when combined with Boceprevir.
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Boceprevir.
GrepafloxacinThe serum concentration of Boceprevir can be increased when it is combined with Grepafloxacin.
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Boceprevir.
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Boceprevir.
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Boceprevir.
HaloperidolThe serum concentration of Boceprevir can be increased when it is combined with Haloperidol.
HalothaneThe metabolism of Halothane can be decreased when combined with Boceprevir.
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Boceprevir.
HirulogThe serum concentration of Hirulog can be decreased when it is combined with Boceprevir.
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Boceprevir.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Boceprevir.
HydrocortisoneThe serum concentration of Boceprevir can be increased when it is combined with Hydrocortisone.
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Boceprevir.
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Boceprevir.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Boceprevir.
IdelalisibThe serum concentration of Boceprevir can be increased when it is combined with Idelalisib.
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Boceprevir resulting in a loss in efficacy.
IloperidoneThe serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Boceprevir.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Boceprevir.
ImatinibThe metabolism of Boceprevir can be decreased when combined with Imatinib.
ImidafenacinThe serum concentration of Imidafenacin can be increased when it is combined with Boceprevir.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Boceprevir.
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Boceprevir.
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Boceprevir.
IndapamideThe metabolism of Indapamide can be decreased when combined with Boceprevir.
IndinavirThe serum concentration of Indinavir can be decreased when it is combined with Boceprevir.
IndomethacinThe serum concentration of Boceprevir can be increased when it is combined with Indomethacin.
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Boceprevir.
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be increased when Irinotecan is used in combination with Boceprevir.
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Boceprevir.
IsavuconazoniumThe metabolism of Boceprevir can be decreased when combined with Isavuconazonium.
IsoflurophateThe serum concentration of Isoflurophate can be decreased when it is combined with Boceprevir.
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Boceprevir.
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Boceprevir.
IsradipineThe metabolism of Boceprevir can be decreased when combined with Isradipine.
ItraconazoleThe metabolism of Itraconazole can be decreased when combined with Boceprevir.
ItraconazoleThe serum concentration of Boceprevir can be increased when it is combined with Itraconazole.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Boceprevir.
IvacaftorThe serum concentration of Boceprevir can be increased when it is combined with Ivacaftor.
IvermectinThe metabolism of Ivermectin can be decreased when combined with Boceprevir.
IvermectinThe serum concentration of Boceprevir can be increased when it is combined with Ivermectin.
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Boceprevir.
IxazomibThe serum concentration of Ixazomib can be decreased when it is combined with Boceprevir.
KetamineThe metabolism of Ketamine can be decreased when combined with Boceprevir.
KetamineThe serum concentration of Boceprevir can be increased when it is combined with Ketamine.
KetazolamThe metabolism of Ketazolam can be decreased when combined with Boceprevir.
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Boceprevir.
KetoconazoleThe metabolism of Ketoconazole can be decreased when combined with Boceprevir.
KetoconazoleThe serum concentration of Boceprevir can be increased when it is combined with Ketoconazole.
LacosamideThe serum concentration of Lacosamide can be increased when it is combined with Boceprevir.
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Boceprevir.
LansoprazoleThe serum concentration of Boceprevir can be increased when it is combined with Lansoprazole.
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Boceprevir.
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Boceprevir.
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Boceprevir.
LepirudinThe serum concentration of Lepirudin can be decreased when it is combined with Boceprevir.
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Boceprevir.
LetrozoleThe metabolism of Letrozole can be decreased when combined with Boceprevir.
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Boceprevir.
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Boceprevir.
LevofloxacinThe serum concentration of Boceprevir can be increased when it is combined with Levofloxacin.
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Boceprevir.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Boceprevir.
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Boceprevir.
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Boceprevir.
LevothyroxineThe serum concentration of Boceprevir can be decreased when it is combined with Levothyroxine.
LidocaineThe metabolism of Lidocaine can be decreased when combined with Boceprevir.
LidocaineThe serum concentration of Boceprevir can be increased when it is combined with Lidocaine.
LinagliptinThe serum concentration of Linagliptin can be decreased when it is combined with Boceprevir.
LiothyronineThe serum concentration of Boceprevir can be decreased when it is combined with Liothyronine.
LiotrixThe serum concentration of Boceprevir can be decreased when it is combined with Liotrix.
LisinoprilThe serum concentration of Lisinopril can be decreased when it is combined with Boceprevir.
LisinoprilThe serum concentration of Boceprevir can be increased when it is combined with Lisinopril.
LisurideThe metabolism of Lisuride can be decreased when combined with Boceprevir.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Boceprevir.
LoperamideThe metabolism of Loperamide can be decreased when combined with Boceprevir.
LoperamideThe serum concentration of Boceprevir can be increased when it is combined with Loperamide.
LopinavirThe serum concentration of Lopinavir can be decreased when it is combined with Boceprevir.
LopinavirThe serum concentration of Boceprevir can be increased when it is combined with Lopinavir.
LoratadineThe metabolism of Loratadine can be decreased when combined with Boceprevir.
LoratadineThe serum concentration of Boceprevir can be increased when it is combined with Loratadine.
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Boceprevir.
LosartanThe metabolism of Losartan can be decreased when combined with Boceprevir.
LosartanThe serum concentration of Boceprevir can be increased when it is combined with Losartan.
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Boceprevir.
LovastatinThe metabolism of Boceprevir can be decreased when combined with Lovastatin.
LuliconazoleThe serum concentration of Boceprevir can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Boceprevir can be decreased when it is combined with Lumacaftor.
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Boceprevir.
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Boceprevir.
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Boceprevir.
MaprotilineThe serum concentration of Boceprevir can be increased when it is combined with Maprotiline.
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Boceprevir.
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Boceprevir.
MebendazoleThe serum concentration of Boceprevir can be increased when it is combined with Mebendazole.
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Boceprevir.
MedrysoneThe serum concentration of Medrysone can be increased when it is combined with Boceprevir.
MefloquineThe metabolism of Mefloquine can be decreased when combined with Boceprevir.
MefloquineThe serum concentration of Boceprevir can be increased when it is combined with Mefloquine.
Megestrol acetateThe serum concentration of Boceprevir can be increased when it is combined with Megestrol acetate.
MelengestrolThe serum concentration of Melengestrol can be increased when it is combined with Boceprevir.
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Boceprevir.
MeprobamateThe serum concentration of Boceprevir can be increased when it is combined with Meprobamate.
MethadoneThe serum concentration of Methadone can be increased when it is combined with Boceprevir.
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Boceprevir.
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Boceprevir.
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Boceprevir.
MethylergometrineThe serum concentration of Methylergometrine can be increased when it is combined with Boceprevir.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Boceprevir.
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Boceprevir.
MetoprololThe serum concentration of Boceprevir can be increased when it is combined with Metoprolol.
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Boceprevir.
MexiletineThe metabolism of Mexiletine can be decreased when combined with Boceprevir.
MianserinThe metabolism of Mianserin can be decreased when combined with Boceprevir.
MibefradilThe metabolism of Mibefradil can be decreased when combined with Boceprevir.
MibefradilThe serum concentration of Boceprevir can be increased when it is combined with Mibefradil.
MiconazoleThe metabolism of Miconazole can be decreased when combined with Boceprevir.
MiconazoleThe serum concentration of Boceprevir can be increased when it is combined with Miconazole.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Boceprevir.
MidazolamThe serum concentration of Boceprevir can be decreased when it is combined with Midazolam.
MifepristoneThe serum concentration of Mifepristone can be increased when it is combined with Boceprevir.
MifepristoneThe metabolism of Boceprevir can be decreased when combined with Mifepristone.
MirabegronThe metabolism of Mirabegron can be decreased when combined with Boceprevir.
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Boceprevir.
MitomycinThe serum concentration of Boceprevir can be increased when it is combined with Mitomycin.
MitotaneThe serum concentration of Boceprevir can be decreased when it is combined with Mitotane.
MitoxantroneThe serum concentration of Boceprevir can be decreased when it is combined with Mitoxantrone.
ModafinilThe serum concentration of Boceprevir can be decreased when it is combined with Modafinil.
ModafinilThe metabolism of Modafinil can be decreased when combined with Boceprevir.
MoexiprilThe serum concentration of Moexipril can be decreased when it is combined with Boceprevir.
MometasoneThe serum concentration of Mometasone can be increased when it is combined with Boceprevir.
MontelukastThe metabolism of Montelukast can be decreased when combined with Boceprevir.
MorphineThe metabolism of Morphine can be decreased when combined with Boceprevir.
MorphineThe serum concentration of Boceprevir can be increased when it is combined with Morphine.
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Boceprevir.
N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-ProlineThe serum concentration of N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline can be decreased when it is combined with Boceprevir.
NafcillinThe serum concentration of Boceprevir can be decreased when it is combined with Nafcillin.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Boceprevir.
NaloxoneThe metabolism of Naloxone can be decreased when combined with Boceprevir.
NaltrexoneThe serum concentration of Boceprevir can be increased when it is combined with Naltrexone.
NaringeninThe serum concentration of Boceprevir can be increased when it is combined with Naringenin.
NateglinideThe metabolism of Nateglinide can be decreased when combined with Boceprevir.
NCX 4016The serum concentration of NCX 4016 can be decreased when it is combined with Boceprevir.
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Boceprevir.
NefazodoneThe serum concentration of Boceprevir can be decreased when it is combined with Nefazodone.
NelfinavirThe serum concentration of Nelfinavir can be decreased when it is combined with Boceprevir.
NeostigmineThe serum concentration of Boceprevir can be increased when it is combined with Neostigmine.
NetupitantThe serum concentration of Boceprevir can be increased when it is combined with Netupitant.
NevirapineThe serum concentration of Boceprevir can be decreased when it is combined with Nevirapine.
NevirapineThe metabolism of Nevirapine can be decreased when combined with Boceprevir.
NicardipineThe metabolism of Nicardipine can be decreased when combined with Boceprevir.
NicardipineThe serum concentration of Boceprevir can be increased when it is combined with Nicardipine.
NicotineThe metabolism of Nicotine can be decreased when combined with Boceprevir.
NifedipineThe metabolism of Nifedipine can be decreased when combined with Boceprevir.
NifedipineThe serum concentration of Boceprevir can be decreased when it is combined with Nifedipine.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Boceprevir.
NilotinibThe metabolism of Boceprevir can be decreased when combined with Nilotinib.
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Boceprevir.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Boceprevir.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Boceprevir.
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Boceprevir.
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Boceprevir.
NitrazepamThe serum concentration of Boceprevir can be increased when it is combined with Nitrazepam.
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Boceprevir.
NitrendipineThe serum concentration of Boceprevir can be increased when it is combined with Nitrendipine.
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Boceprevir.
NorethisteroneThe serum concentration of Boceprevir can be decreased when it is combined with Norethisterone.
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Boceprevir.
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Boceprevir.
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Boceprevir.
OlaparibThe metabolism of Boceprevir can be decreased when combined with Olaparib.
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Boceprevir.
OmapatrilatThe serum concentration of Omapatrilat can be decreased when it is combined with Boceprevir.
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Boceprevir.
OmeprazoleThe serum concentration of Boceprevir can be increased when it is combined with Omeprazole.
OndansetronThe metabolism of Ondansetron can be decreased when combined with Boceprevir.
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Boceprevir.
OsimertinibThe serum concentration of Boceprevir can be increased when it is combined with Osimertinib.
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Boceprevir.
OtamixabanThe serum concentration of Otamixaban can be decreased when it is combined with Boceprevir.
OxazepamThe metabolism of Oxazepam can be decreased when combined with Boceprevir.
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Boceprevir.
OxycodoneThe risk or severity of adverse effects can be increased when Boceprevir is combined with Oxycodone.
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Boceprevir.
P-NitrophenolThe serum concentration of Boceprevir can be increased when it is combined with P-Nitrophenol.
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Boceprevir.
PaclitaxelThe serum concentration of Boceprevir can be increased when it is combined with Paclitaxel.
PalbociclibThe serum concentration of Boceprevir can be increased when it is combined with Palbociclib.
Palmitic AcidThe serum concentration of Boceprevir can be increased when it is combined with Palmitic Acid.
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Boceprevir.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Boceprevir.
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Boceprevir.
PantoprazoleThe serum concentration of Boceprevir can be increased when it is combined with Pantoprazole.
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Boceprevir.
ParamethasoneThe serum concentration of Paramethasone can be increased when it is combined with Boceprevir.
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Boceprevir.
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Boceprevir.
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Boceprevir.
ParoxetineThe serum concentration of Boceprevir can be increased when it is combined with Paroxetine.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Boceprevir.
PentamidineThe metabolism of Pentamidine can be decreased when combined with Boceprevir.
PentobarbitalThe serum concentration of Boceprevir can be decreased when it is combined with Pentobarbital.
PerampanelThe metabolism of Perampanel can be decreased when combined with Boceprevir.
PergolideThe metabolism of Pergolide can be decreased when combined with Boceprevir.
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Boceprevir.
PerindoprilThe serum concentration of Perindopril can be decreased when it is combined with Boceprevir.
PerindoprilThe serum concentration of Boceprevir can be increased when it is combined with Perindopril.
PermethrinThe metabolism of Permethrin can be decreased when combined with Boceprevir.
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Boceprevir.
PethidineThe risk or severity of adverse effects can be increased when Boceprevir is combined with Pethidine.
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Boceprevir.
PhenobarbitalThe serum concentration of Boceprevir can be decreased when it is combined with Phenobarbital.
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Boceprevir.
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Boceprevir.
PhenytoinThe serum concentration of Boceprevir can be decreased when it is combined with Phenytoin.
PhenytoinThe metabolism of Phenytoin can be decreased when combined with Boceprevir.
PhosphoramidonThe serum concentration of Phosphoramidon can be decreased when it is combined with Boceprevir.
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Boceprevir.
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Boceprevir.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Boceprevir.
PinacidilThe metabolism of Pinacidil can be decreased when combined with Boceprevir.
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Boceprevir.
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Boceprevir.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Boceprevir.
Platelet Activating FactorThe serum concentration of Boceprevir can be decreased when it is combined with Platelet Activating Factor.
PodofiloxThe metabolism of Podofilox can be decreased when combined with Boceprevir.
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Boceprevir.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Boceprevir.
PosaconazoleThe serum concentration of Boceprevir can be increased when it is combined with Posaconazole.
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Boceprevir.
PranlukastThe serum concentration of Pranlukast can be increased when it is combined with Boceprevir.
PrasugrelThe serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Boceprevir resulting in a loss in efficacy.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Boceprevir.
PrazepamThe metabolism of Prazepam can be decreased when combined with Boceprevir.
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Boceprevir.
PrazosinThe serum concentration of Boceprevir can be increased when it is combined with Prazosin.
PrednicarbateThe serum concentration of Prednicarbate can be increased when it is combined with Boceprevir.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Boceprevir.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Boceprevir.
PregnenoloneThe serum concentration of Pregnenolone can be increased when it is combined with Boceprevir.
PrimaquineThe metabolism of Primaquine can be decreased when combined with Boceprevir.
PrimidoneThe serum concentration of Boceprevir can be decreased when it is combined with Primidone.
PrinomastatThe serum concentration of Prinomastat can be decreased when it is combined with Boceprevir.
ProbenecidThe serum concentration of Boceprevir can be increased when it is combined with Probenecid.
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Boceprevir.
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Boceprevir.
ProgesteroneThe serum concentration of Boceprevir can be decreased when it is combined with Progesterone.
ProguanilThe metabolism of Proguanil can be decreased when combined with Boceprevir.
PromazineThe metabolism of Promazine can be decreased when combined with Boceprevir.
PromethazineThe serum concentration of Boceprevir can be increased when it is combined with Promethazine.
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Boceprevir.
PropofolThe metabolism of Propofol can be decreased when combined with Boceprevir.
PropranololThe metabolism of Propranolol can be decreased when combined with Boceprevir.
PropranololThe serum concentration of Boceprevir can be increased when it is combined with Propranolol.
ProtriptylineThe serum concentration of Protriptyline can be increased when it is combined with Boceprevir.
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Boceprevir.
QuazepamThe metabolism of Quazepam can be decreased when combined with Boceprevir.
QuercetinThe serum concentration of Boceprevir can be increased when it is combined with Quercetin.
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Boceprevir.
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Boceprevir.
QuinacrineThe serum concentration of Boceprevir can be increased when it is combined with Quinacrine.
QuinaprilThe serum concentration of Quinapril can be decreased when it is combined with Boceprevir.
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Boceprevir.
QuinineThe metabolism of Quinine can be decreased when combined with Boceprevir.
QuinineThe serum concentration of Boceprevir can be increased when it is combined with Quinine.
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Boceprevir.
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Boceprevir.
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Boceprevir.
RamiprilThe serum concentration of Ramipril can be decreased when it is combined with Boceprevir.
RanitidineThe serum concentration of Boceprevir can be increased when it is combined with Ranitidine.
RanolazineThe serum concentration of Boceprevir can be increased when it is combined with Ranolazine.
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Boceprevir.
ReboxetineThe serum concentration of Boceprevir can be increased when it is combined with Reboxetine.
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Boceprevir.
RemikirenThe serum concentration of Remikiren can be decreased when it is combined with Boceprevir.
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Boceprevir.
ReserpineThe serum concentration of Boceprevir can be decreased when it is combined with Reserpine.
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Boceprevir.
RifabutinThe serum concentration of Boceprevir can be decreased when it is combined with Rifabutin.
RifabutinThe metabolism of Rifabutin can be decreased when combined with Boceprevir.
RifampicinThe serum concentration of Boceprevir can be decreased when it is combined with Rifampicin.
RifampicinThe metabolism of Rifampicin can be decreased when combined with Boceprevir.
RifapentineThe serum concentration of Boceprevir can be decreased when it is combined with Rifapentine.
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Boceprevir.
RimexoloneThe serum concentration of Rimexolone can be increased when it is combined with Boceprevir.
RimonabantThe metabolism of Rimonabant can be decreased when combined with Boceprevir.
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Boceprevir.
RisperidoneThe metabolism of Risperidone can be decreased when combined with Boceprevir.
RitonavirThe serum concentration of Boceprevir can be decreased when it is combined with Ritonavir.
RivaroxabanThe serum concentration of Rivaroxaban can be decreased when it is combined with Boceprevir.
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Boceprevir.
RolapitantThe metabolism of Rolapitant can be decreased when combined with Boceprevir.
RolapitantThe serum concentration of Boceprevir can be increased when it is combined with Rolapitant.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Boceprevir.
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Boceprevir.
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Boceprevir.
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Boceprevir.
RotigotineThe metabolism of Rotigotine can be decreased when combined with Boceprevir.
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Boceprevir.
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Boceprevir.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Boceprevir.
SaquinavirThe serum concentration of Saquinavir can be decreased when it is combined with Boceprevir.
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Boceprevir.
ScopolamineThe serum concentration of Boceprevir can be increased when it is combined with Scopolamine.
SelegilineThe metabolism of Selegiline can be decreased when combined with Boceprevir.
SelegilineThe serum concentration of Boceprevir can be increased when it is combined with Selegiline.
SelexipagThe metabolism of Selexipag can be decreased when combined with Boceprevir.
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Boceprevir.
SertindoleThe metabolism of Sertindole can be decreased when combined with Boceprevir.
SertralineThe metabolism of Sertraline can be decreased when combined with Boceprevir.
SertralineThe serum concentration of Boceprevir can be increased when it is combined with Sertraline.
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Boceprevir.
SibutramineThe metabolism of Sibutramine can be decreased when combined with Boceprevir.
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Boceprevir.
SildenafilThe metabolism of Boceprevir can be decreased when combined with Sildenafil.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Boceprevir.
SiltuximabThe serum concentration of Boceprevir can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Boceprevir can be increased when it is combined with Simeprevir.
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Boceprevir.
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Boceprevir.
SirolimusThe serum concentration of Boceprevir can be decreased when it is combined with Sirolimus.
SitagliptinThe serum concentration of Sitagliptin can be decreased when it is combined with Boceprevir.
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Boceprevir.
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Boceprevir.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Boceprevir.
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Boceprevir.
SpiraprilThe serum concentration of Spirapril can be decreased when it is combined with Boceprevir.
SpironolactoneThe serum concentration of Boceprevir can be increased when it is combined with Spironolactone.
St. John's WortThe metabolism of Boceprevir can be increased when combined with St. John's Wort.
StaurosporineThe serum concentration of Boceprevir can be increased when it is combined with Staurosporine.
StiripentolThe serum concentration of Boceprevir can be increased when it is combined with Stiripentol.
StreptozocinThe serum concentration of Boceprevir can be decreased when it is combined with Streptozocin.
SufentanilThe metabolism of Sufentanil can be decreased when combined with Boceprevir.
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Boceprevir.
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Boceprevir.
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Boceprevir.
SulfinpyrazoneThe serum concentration of Boceprevir can be increased when it is combined with Sulfinpyrazone.
SulfisoxazoleThe metabolism of Boceprevir can be decreased when combined with Sulfisoxazole.
SumatriptanThe serum concentration of Boceprevir can be increased when it is combined with Sumatriptan.
SunitinibThe metabolism of Sunitinib can be decreased when combined with Boceprevir.
SunitinibThe serum concentration of Boceprevir can be increased when it is combined with Sunitinib.
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Boceprevir.
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Boceprevir.
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Boceprevir.
TacrineThe serum concentration of Boceprevir can be increased when it is combined with Tacrine.
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Boceprevir.
TacrolimusThe serum concentration of Boceprevir can be decreased when it is combined with Tacrolimus.
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Boceprevir.
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Boceprevir.
TamoxifenThe serum concentration of Boceprevir can be decreased when it is combined with Tamoxifen.
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Boceprevir.
TasimelteonThe serum concentration of Tasimelteon can be increased when it is combined with Boceprevir.
TasosartanThe metabolism of Tasosartan can be decreased when combined with Boceprevir.
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Boceprevir.
Taurocholic AcidThe serum concentration of Boceprevir can be increased when it is combined with Taurocholic Acid.
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Boceprevir.
TelaprevirThe metabolism of Boceprevir can be decreased when combined with Telaprevir.
TelithromycinThe metabolism of Boceprevir can be decreased when combined with Telithromycin.
TelmisartanThe serum concentration of Boceprevir can be increased when it is combined with Telmisartan.
TemazepamThe metabolism of Temazepam can be decreased when combined with Boceprevir.
TemocaprilThe serum concentration of Temocapril can be decreased when it is combined with Boceprevir.
TemsirolimusThe risk or severity of adverse effects can be increased when Boceprevir is combined with Temsirolimus.
TemsirolimusThe serum concentration of Boceprevir can be increased when it is combined with Temsirolimus.
TeniposideThe metabolism of Teniposide can be decreased when combined with Boceprevir.
TerazosinThe serum concentration of Boceprevir can be increased when it is combined with Terazosin.
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Boceprevir.
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Boceprevir.
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Boceprevir.
TesmilifeneThe serum concentration of Boceprevir can be decreased when it is combined with Tesmilifene.
TestosteroneThe metabolism of Testosterone can be decreased when combined with Boceprevir.
TestosteroneThe serum concentration of Boceprevir can be increased when it is combined with Testosterone.
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Boceprevir.
TheophyllineThe serum concentration of Theophylline can be decreased when it is combined with Boceprevir.
ThiorphanThe serum concentration of Thiorphan can be decreased when it is combined with Boceprevir.
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Boceprevir.
TiagabineThe metabolism of Tiagabine can be decreased when combined with Boceprevir.
TianeptineThe serum concentration of Tianeptine can be increased when it is combined with Boceprevir.
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Boceprevir resulting in a loss in efficacy.
TicagrelorThe serum concentration of Boceprevir can be increased when it is combined with Ticagrelor.
TiclopidineThe metabolism of Boceprevir can be decreased when combined with Ticlopidine.
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Boceprevir.
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Boceprevir.
TipranavirThe serum concentration of Tipranavir can be decreased when it is combined with Boceprevir.
TixocortolThe serum concentration of Tixocortol can be increased when it is combined with Boceprevir.
TocilizumabThe serum concentration of Boceprevir can be decreased when it is combined with Tocilizumab.
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Boceprevir.
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Boceprevir.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Boceprevir.
ToremifeneThe risk or severity of adverse effects can be increased when Boceprevir is combined with Toremifene.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Boceprevir.
TramadolThe serum concentration of Tramadol can be increased when it is combined with Boceprevir.
TrandolaprilThe serum concentration of Trandolapril can be decreased when it is combined with Boceprevir.
Trastuzumab emtansineThe serum concentration of the active metabolites of Trastuzumab emtansine can be increased when Trastuzumab emtansine is used in combination with Boceprevir.
TrazodoneThe serum concentration of Trazodone can be increased when it is combined with Boceprevir.
TrazodoneThe serum concentration of Boceprevir can be decreased when it is combined with Trazodone.
TretinoinThe metabolism of Tretinoin can be decreased when combined with Boceprevir.
TriamcinoloneThe serum concentration of Triamcinolone can be increased when it is combined with Boceprevir.
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Boceprevir.
TrifluoperazineThe serum concentration of Boceprevir can be increased when it is combined with Trifluoperazine.
TriflupromazineThe serum concentration of Boceprevir can be increased when it is combined with Triflupromazine.
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Boceprevir.
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Boceprevir.
TrimethoprimThe serum concentration of Boceprevir can be decreased when it is combined with Trimethoprim.
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Boceprevir.
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Boceprevir.
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Boceprevir.
TroleandomycinThe serum concentration of Boceprevir can be increased when it is combined with Troleandomycin.
UbenimexThe serum concentration of Ubenimex can be decreased when it is combined with Boceprevir.
UdenafilThe metabolism of Udenafil can be decreased when combined with Boceprevir.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Boceprevir.
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Boceprevir.
VandetanibThe metabolism of Vandetanib can be decreased when combined with Boceprevir.
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Boceprevir.
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Boceprevir.
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Boceprevir.
VenlafaxineThe metabolism of Boceprevir can be decreased when combined with Venlafaxine.
VerapamilThe metabolism of Boceprevir can be decreased when combined with Verapamil.
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Boceprevir.
VilanterolThe metabolism of Vilanterol can be decreased when combined with Boceprevir.
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Boceprevir.
VildagliptinThe serum concentration of Vildagliptin can be decreased when it is combined with Boceprevir.
VinblastineThe metabolism of Vinblastine can be decreased when combined with Boceprevir.
VinblastineThe serum concentration of Boceprevir can be decreased when it is combined with Vinblastine.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Boceprevir.
VincristineThe serum concentration of Boceprevir can be decreased when it is combined with Vincristine.
VindesineThe serum concentration of Vindesine can be increased when it is combined with Boceprevir.
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Boceprevir.
VinorelbineThe serum concentration of Boceprevir can be increased when it is combined with Vinorelbine.
VismodegibThe metabolism of Vismodegib can be decreased when combined with Boceprevir.
VorapaxarThe serum concentration of Vorapaxar can be increased when it is combined with Boceprevir.
VoriconazoleThe serum concentration of Voriconazole can be increased when it is combined with Boceprevir.
VoriconazoleThe metabolism of Boceprevir can be decreased when combined with Voriconazole.
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Boceprevir.
WarfarinThe serum concentration of Warfarin can be decreased when it is combined with Boceprevir.
XimelagatranThe serum concentration of Ximelagatran can be decreased when it is combined with Boceprevir.
YohimbineThe metabolism of Yohimbine can be decreased when combined with Boceprevir.
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Boceprevir.
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Boceprevir.
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Boceprevir.
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Boceprevir.
ZileutonThe metabolism of Zileuton can be decreased when combined with Boceprevir.
ZimelidineThe serum concentration of Boceprevir can be increased when it is combined with Zimelidine.
ZiprasidoneThe metabolism of Boceprevir can be decreased when combined with Ziprasidone.
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Boceprevir.
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Boceprevir.
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Boceprevir.
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Boceprevir.
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Boceprevir.
Food Interactions
  • Food increases the exposure of boceprevir by up to 65%. However, bioavailability is not affected and thus can be taken without regards to meals.

Targets

Kind
Protein
Organism
Hepatitis C virus
Pharmacological action
yes
Actions
inhibitor
General Function:
Serine-type peptidase activity
Specific Function:
Not Available
Gene Name:
NS3/4A
Uniprot ID:
B0B3C9
Molecular Weight:
72789.28 Da
References
  1. Ali A, Aydin C, Gildemeister R, Romano KP, Cao H, Ozen A, Soumana D, Newton A, Petropoulos CJ, Huang W, Schiffer CA: Evaluating the role of macrocycles in the susceptibility of hepatitis C virus NS3/4A protease inhibitors to drug resistance. ACS Chem Biol. 2013 Jul 19;8(7):1469-78. doi: 10.1021/cb400100g. Epub 2013 May 1. [PubMed:23594083 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Kiser JJ, Flexner C: Direct-acting antiviral agents for hepatitis C virus infection. Annu Rev Pharmacol Toxicol. 2013;53:427-49. doi: 10.1146/annurev-pharmtox-011112-140254. Epub 2012 Nov 5. [PubMed:23140245 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Kiser JJ, Flexner C: Direct-acting antiviral agents for hepatitis C virus infection. Annu Rev Pharmacol Toxicol. 2013;53:427-49. doi: 10.1146/annurev-pharmtox-011112-140254. Epub 2012 Nov 5. [PubMed:23140245 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Kiser JJ, Flexner C: Direct-acting antiviral agents for hepatitis C virus infection. Annu Rev Pharmacol Toxicol. 2013;53:427-49. doi: 10.1146/annurev-pharmtox-011112-140254. Epub 2012 Nov 5. [PubMed:23140245 ]
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Drug created on May 11, 2013 22:45 / Updated on September 28, 2016 02:28