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Identification
NameEnzalutamide
Accession NumberDB08899
TypeSmall Molecule
GroupsApproved
DescriptionEnzalutamide is an androgen receptor inhibitor for the treatment of castration-resistant prostate cancer. FDA approved on August 31, 2012.
Structure
Thumb
Synonyms
MDV 3100
MDV-3100
MDV3100
XTANDI
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Xtandicapsule40 mg/1oralAstellas Pharma US, Inc.2012-08-31Not applicableUs
Xtandicapsule40 mgoralAstellas Pharma Canada Inc2013-06-07Not applicableCanada
XtandiCapsule, soft40 mgOral useAstellas Pharma Europe B.V.2013-06-21Not applicableEu
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNII93T0T9GKNU
CAS number915087-33-1
WeightAverage: 464.436
Monoisotopic: 464.093009286
Chemical FormulaC21H16F4N4O2S
InChI KeyInChIKey=WXCXUHSOUPDCQV-UHFFFAOYSA-N
InChI
InChI=1S/C21H16F4N4O2S/c1-20(2)18(31)28(12-5-4-11(10-26)15(8-12)21(23,24)25)19(32)29(20)13-6-7-14(16(22)9-13)17(30)27-3/h4-9H,1-3H3,(H,27,30)
IUPAC Name
4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl}-2-fluoro-N-methylbenzamide
SMILES
CNC(=O)C1=C(F)C=C(C=C1)N1C(=S)N(C(=O)C1(C)C)C1=CC=C(C#N)C(=C1)C(F)(F)F
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenylimidazolidines. These are polycyclic compounds containing an imidazoline substituted by a phenyl group.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassAzolidines
Sub ClassImidazolidines
Direct ParentPhenylimidazolidines
Alternative Parents
Substituents
  • Phenylimidazolidine
  • Halobenzoic acid or derivatives
  • 2-halobenzoic acid or derivatives
  • N-phenylthiourea
  • Aminobenzoic acid or derivatives
  • Benzoic acid or derivatives
  • Benzamide
  • Aminobenzamide
  • Benzoyl
  • Benzonitrile
  • Halobenzene
  • Fluorobenzene
  • Benzenoid
  • Imidazolidinone
  • Monocyclic benzene moiety
  • Aryl halide
  • Aryl fluoride
  • Vinylogous halide
  • Thiourea
  • Tertiary amine
  • Secondary carboxylic acid amide
  • Thiocarbonic acid derivative
  • Carboxamide group
  • Azacycle
  • Nitrile
  • Carbonitrile
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organosulfur compound
  • Organooxygen compound
  • Organonitrogen compound
  • Organofluoride
  • Organohalogen compound
  • Carbonyl group
  • Amine
  • Alkyl halide
  • Alkyl fluoride
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationEnzalutamide is indicated for the treatment of patients with metastatic castration-resistant prostate cancer who have previously received docetaxel.
PharmacodynamicsResitance to enzalutamide therapy has been observed. This may occurred due to an upregulation of NF-κB2/p52.
Mechanism of actionEnzalutamide is a competitive androgen receptor inhibitor that effects multiple stages of the signalling pathway. It is able to inhibit androgen binding to its receptor, androgen receptor nuclear translocation, and subsequent interaction with DNA. As a result, proliferation of prostate cancer cells decreases which ultimately leads to apoptosis and decreased tumour volume.
Related Articles
AbsorptionThe pharmacokinetic profile of enzalutamide and N-desmethyl enzalutamide (its major active metabolite) is described by a linear two-compartment model with first-order absorption. Enzalutamide also accumulates. Food does not affect its absorption. Tmax, prostate cancer patients = 1 hour (range of 0.5-3 hours); Cmax, steady state, enzalutamide = 16.6 μg/mL; Cmax, steady state, N-desmethyl enzalutamide = 12.7 μg/mL; Time to steady state, daily dosing = 28 days;
Volume of distribution

Apparent volume of distribution (Vd/F), single oral dose = 110 L

Protein bindingEnzalutamide is 97% to 98% bound to plasma proteins, primarily albumin. N-desmethyl enzalutamide is 95% bound to plasma proteins.
Metabolism

Enzalutamide is hepatically metabolized, primarily by CYP2C8 and CYP3A4. The enzyme that converts enzalutamide to its active metabolite, N-desmethyl enzalutamide, is CYP2C8. The activity of N-desmethyl-enzalutamide is similar to that of the parent compound.

Route of eliminationEnzalutamide is primarily eliminated by hepatic metabolism. 71% of the dose is recovered in urine (including only trace amounts of enzalutamide and N-desmethyl enzalutamide), and 14% is recovered in feces (0.4% of dose as unchanged enzalutamide and 1% as N-desmethyl enzalutamide).
Half lifeThe mean terminal half-life (t1/2) for enzalutamide in patients after a single oral dose is 5.8 days (range 2.8 to 10.2 days). Following a single 160 mg oral dose of enzalutamide in healthy volunteers, the mean terminal t1/2 for N-desmethyl enzalutamide is approximately 7.8 to 8.6 days.
Clearance

Apparent clearance (CL/F), single oral dose = 0.56 L/h (range of 0.33 – 1.02 L/h)

ToxicityThe most common adverse reactions (≥ 5%) are asthenia/fatigue, back pain, diarrhea, arthralgia, hot flush, peripheral edema, musculoskeletal pain, headache, upper respiratory infection, muscular weakness, dizziness, insomnia, lower respiratory infection, spinal cord compression and cauda equina syndrome, hematuria, paresthesia, anxiety, and hypertension.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9356
Blood Brain Barrier+0.8514
Caco-2 permeable+0.5219
P-glycoprotein substrateNon-substrate0.7609
P-glycoprotein inhibitor IInhibitor0.6464
P-glycoprotein inhibitor IIInhibitor0.5693
Renal organic cation transporterNon-inhibitor0.899
CYP450 2C9 substrateNon-substrate0.7447
CYP450 2D6 substrateNon-substrate0.8061
CYP450 3A4 substrateSubstrate0.5589
CYP450 1A2 substrateNon-inhibitor0.5613
CYP450 2C9 inhibitorInhibitor0.7126
CYP450 2D6 inhibitorNon-inhibitor0.9148
CYP450 2C19 inhibitorInhibitor0.6882
CYP450 3A4 inhibitorInhibitor0.6184
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.6711
Ames testNon AMES toxic0.683
CarcinogenicityNon-carcinogens0.7232
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.4319 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9911
hERG inhibition (predictor II)Inhibitor0.7079
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
Capsuleoral40 mg/1
Capsuleoral40 mg
Capsule, softOral use40 mg
PricesNot Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US7709517 No2007-08-132027-08-13Us
US8183274 No2006-05-152026-05-15Us
US9126941 No2006-05-152026-05-15Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
water solubilityInsoluble FDA label
Predicted Properties
PropertyValueSource
Water Solubility0.00136 mg/mLALOGPS
logP3.75ALOGPS
logP4.16ChemAxon
logS-5.5ALOGPS
pKa (Strongest Acidic)13.05ChemAxon
pKa (Strongest Basic)-1.7ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area76.44 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity113.48 m3·mol-1ChemAxon
Polarizability42.71 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis ReferenceNot Available
General References
  1. Nadiminty N, Tummala R, Liu C, Yang J, Lou W, Evans CP, Gao AC: NF-kappaB2/p52 induces resistance to enzalutamide in prostate cancer: role of androgen receptor and its variants. Mol Cancer Ther. 2013 Aug;12(8):1629-37. doi: 10.1158/1535-7163.MCT-13-0027. Epub 2013 May 22. [PubMed:23699654 ]
External Links
ATC CodesL02BB04
AHFS Codes
  • 10:00
PDB EntriesNot Available
FDA labelDownload (393 KB)
MSDSDownload (89.7 KB)
Interactions
Drug Interactions
Drug
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be decreased when it is combined with Enzalutamide.
AbirateroneThe serum concentration of Abiraterone can be decreased when it is combined with Enzalutamide.
AbirateroneThe serum concentration of Enzalutamide can be increased when it is combined with Abiraterone.
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Enzalutamide.
AcenocoumarolThe serum concentration of Acenocoumarol can be decreased when it is combined with Enzalutamide.
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Enzalutamide.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Enzalutamide.
AdinazolamThe serum concentration of Adinazolam can be decreased when it is combined with Enzalutamide.
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Enzalutamide.
AlbendazoleThe serum concentration of Albendazole can be decreased when it is combined with Enzalutamide.
AlclometasoneThe serum concentration of Alclometasone can be decreased when it is combined with Enzalutamide.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Enzalutamide.
AlfentanilThe serum concentration of Alfentanil can be decreased when it is combined with Enzalutamide.
AlfuzosinThe serum concentration of Alfuzosin can be decreased when it is combined with Enzalutamide.
AliskirenThe serum concentration of Aliskiren can be decreased when it is combined with Enzalutamide.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Enzalutamide.
AllylestrenolThe serum concentration of Allylestrenol can be decreased when it is combined with Enzalutamide.
AlmotriptanThe serum concentration of Almotriptan can be decreased when it is combined with Enzalutamide.
AlogliptinThe serum concentration of Alogliptin can be decreased when it is combined with Enzalutamide.
AlosetronThe serum concentration of Alosetron can be decreased when it is combined with Enzalutamide.
AlprazolamThe serum concentration of Alprazolam can be decreased when it is combined with Enzalutamide.
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Enzalutamide.
AmbroxolThe serum concentration of Ambroxol can be decreased when it is combined with Enzalutamide.
AmcinonideThe serum concentration of Amcinonide can be decreased when it is combined with Enzalutamide.
AminophenazoneThe serum concentration of Aminophenazone can be decreased when it is combined with Enzalutamide.
AminophyllineThe serum concentration of Aminophylline can be decreased when it is combined with Enzalutamide.
AmiodaroneThe serum concentration of Enzalutamide can be increased when it is combined with Amiodarone.
AmiodaroneThe serum concentration of Amiodarone can be decreased when it is combined with Enzalutamide.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Enzalutamide.
AmlodipineThe serum concentration of Amlodipine can be decreased when it is combined with Enzalutamide.
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Enzalutamide.
AmprenavirThe serum concentration of Amprenavir can be decreased when it is combined with Enzalutamide.
AntipyrineThe serum concentration of Antipyrine can be decreased when it is combined with Enzalutamide.
ApixabanThe serum concentration of Apixaban can be decreased when it is combined with Enzalutamide.
ApremilastThe serum concentration of Apremilast can be decreased when it is combined with Enzalutamide.
AprepitantThe serum concentration of Enzalutamide can be increased when it is combined with Aprepitant.
AprepitantThe serum concentration of Aprepitant can be decreased when it is combined with Enzalutamide.
ArgatrobanThe serum concentration of Argatroban can be decreased when it is combined with Enzalutamide.
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Enzalutamide.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Enzalutamide.
ArtemetherThe serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with Enzalutamide resulting in a loss in efficacy.
AsenapineThe serum concentration of Asenapine can be decreased when it is combined with Enzalutamide.
AstemizoleThe serum concentration of Astemizole can be decreased when it is combined with Enzalutamide.
AtazanavirThe serum concentration of Enzalutamide can be increased when it is combined with Atazanavir.
AtenololThe serum concentration of Atenolol can be increased when it is combined with Enzalutamide.
AtomoxetineThe metabolism of Enzalutamide can be decreased when combined with Atomoxetine.
AtorvastatinThe serum concentration of Atorvastatin can be decreased when it is combined with Enzalutamide.
AvanafilThe serum concentration of Avanafil can be decreased when it is combined with Enzalutamide.
AxitinibThe serum concentration of Axitinib can be decreased when it is combined with Enzalutamide.
AzelastineThe serum concentration of Azelastine can be decreased when it is combined with Enzalutamide.
AzithromycinThe serum concentration of Azithromycin can be decreased when it is combined with Enzalutamide.
BanoxantroneThe serum concentration of Banoxantrone can be decreased when it is combined with Enzalutamide.
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be decreased when it is combined with Enzalutamide.
BedaquilineThe serum concentration of Bedaquiline can be decreased when it is combined with Enzalutamide.
BenzphetamineThe serum concentration of Benzphetamine can be decreased when it is combined with Enzalutamide.
Benzyl alcoholThe serum concentration of Benzyl alcohol can be decreased when it is combined with Enzalutamide.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Enzalutamide.
BexaroteneThe serum concentration of Enzalutamide can be decreased when it is combined with Bexarotene.
BezafibrateThe serum concentration of Bezafibrate can be decreased when it is combined with Enzalutamide.
BicalutamideThe serum concentration of Bicalutamide can be decreased when it is combined with Enzalutamide.
BisoprololThe serum concentration of Bisoprolol can be decreased when it is combined with Enzalutamide.
BoceprevirThe serum concentration of Enzalutamide can be increased when it is combined with Boceprevir.
BoceprevirThe serum concentration of Boceprevir can be decreased when it is combined with Enzalutamide.
BortezomibThe serum concentration of Bortezomib can be decreased when it is combined with Enzalutamide.
BortezomibThe metabolism of Enzalutamide can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Enzalutamide can be decreased when it is combined with Bosentan.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Enzalutamide.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Enzalutamide.
BrexpiprazoleThe serum concentration of Brexpiprazole can be decreased when it is combined with Enzalutamide.
BrinzolamideThe serum concentration of Brinzolamide can be decreased when it is combined with Enzalutamide.
BromazepamThe serum concentration of Bromazepam can be decreased when it is combined with Enzalutamide.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Enzalutamide.
BrompheniramineThe serum concentration of Brompheniramine can be decreased when it is combined with Enzalutamide.
BudesonideThe serum concentration of Budesonide can be decreased when it is combined with Enzalutamide.
BupivacaineThe serum concentration of Bupivacaine can be decreased when it is combined with Enzalutamide.
BuprenorphineThe serum concentration of Buprenorphine can be decreased when it is combined with Enzalutamide.
BupropionThe serum concentration of Bupropion can be decreased when it is combined with Enzalutamide.
BuspironeThe serum concentration of Buspirone can be decreased when it is combined with Enzalutamide.
BusulfanThe serum concentration of Busulfan can be decreased when it is combined with Enzalutamide.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Enzalutamide.
CabergolineThe serum concentration of Cabergoline can be decreased when it is combined with Enzalutamide.
CabozantinibThe serum concentration of Cabozantinib can be decreased when it is combined with Enzalutamide.
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Enzalutamide.
CalcitriolThe serum concentration of Calcitriol can be decreased when it is combined with Enzalutamide.
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Enzalutamide.
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Enzalutamide.
CannabidiolThe serum concentration of Cannabidiol can be decreased when it is combined with Enzalutamide.
CarbamazepineThe serum concentration of Enzalutamide can be decreased when it is combined with Carbamazepine.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Enzalutamide.
CarbinoxamineThe serum concentration of Carbinoxamine can be decreased when it is combined with Enzalutamide.
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Enzalutamide.
CariprazineThe serum concentration of Cariprazine can be decreased when it is combined with Enzalutamide.
CarvedilolThe serum concentration of Carvedilol can be decreased when it is combined with Enzalutamide.
CelecoxibThe serum concentration of Celecoxib can be decreased when it is combined with Enzalutamide.
CelecoxibThe metabolism of Enzalutamide can be decreased when combined with Celecoxib.
CeliprololThe serum concentration of Celiprolol can be decreased when it is combined with Enzalutamide.
CephalexinThe serum concentration of Cephalexin can be decreased when it is combined with Enzalutamide.
CeritinibThe serum concentration of Enzalutamide can be increased when it is combined with Ceritinib.
CeritinibThe serum concentration of Ceritinib can be decreased when it is combined with Enzalutamide.
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Enzalutamide.
CevimelineThe serum concentration of Cevimeline can be decreased when it is combined with Enzalutamide.
Chenodeoxycholic acidThe serum concentration of Chenodeoxycholic acid can be decreased when it is combined with Enzalutamide.
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Enzalutamide.
ChloroquineThe serum concentration of Chloroquine can be decreased when it is combined with Enzalutamide.
ChlorphenamineThe serum concentration of Chlorphenamine can be decreased when it is combined with Enzalutamide.
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Enzalutamide.
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be decreased when it is combined with Enzalutamide.
CholecalciferolThe serum concentration of Cholecalciferol can be decreased when it is combined with Enzalutamide.
CiclesonideThe serum concentration of Ciclesonide can be decreased when it is combined with Enzalutamide.
CilostazolThe serum concentration of Cilostazol can be decreased when it is combined with Enzalutamide.
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Enzalutamide.
CinacalcetThe serum concentration of Cinacalcet can be decreased when it is combined with Enzalutamide.
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Enzalutamide.
CisaprideThe serum concentration of Cisapride can be decreased when it is combined with Enzalutamide.
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Enzalutamide.
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Enzalutamide.
ClarithromycinThe serum concentration of Enzalutamide can be increased when it is combined with Clarithromycin.
ClemastineThe metabolism of Enzalutamide can be decreased when combined with Clemastine.
ClindamycinThe serum concentration of Clindamycin can be decreased when it is combined with Enzalutamide.
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Enzalutamide.
Clobetasol propionateThe serum concentration of Clobetasol propionate can be decreased when it is combined with Enzalutamide.
ClocortoloneThe serum concentration of Clocortolone can be decreased when it is combined with Enzalutamide.
ClofazimineThe serum concentration of Clofazimine can be decreased when it is combined with Enzalutamide.
ClofibrateThe serum concentration of Clofibrate can be decreased when it is combined with Enzalutamide.
clomethiazoleThe serum concentration of clomethiazole can be decreased when it is combined with Enzalutamide.
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Enzalutamide.
ClomipramineThe serum concentration of Clomipramine can be decreased when it is combined with Enzalutamide.
ClonazepamThe serum concentration of Clonazepam can be decreased when it is combined with Enzalutamide.
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Enzalutamide.
ClopidogrelThe serum concentration of Enzalutamide can be increased when it is combined with Clopidogrel.
ClorazepateThe serum concentration of Clorazepate can be decreased when it is combined with Enzalutamide.
ClotiazepamThe serum concentration of Clotiazepam can be decreased when it is combined with Enzalutamide.
ClotrimazoleThe metabolism of Enzalutamide can be decreased when combined with Clotrimazole.
ClozapineThe serum concentration of Clozapine can be decreased when it is combined with Enzalutamide.
CobicistatThe serum concentration of Enzalutamide can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be decreased when it is combined with Enzalutamide.
CocaineThe serum concentration of Cocaine can be decreased when it is combined with Enzalutamide.
CodeineThe serum concentration of Codeine can be decreased when it is combined with Enzalutamide.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Enzalutamide.
ConivaptanThe serum concentration of Enzalutamide can be increased when it is combined with Conivaptan.
ConivaptanThe serum concentration of Conivaptan can be decreased when it is combined with Enzalutamide.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Enzalutamide.
Cortisone acetateThe serum concentration of Cortisone acetate can be decreased when it is combined with Enzalutamide.
CrizotinibThe serum concentration of Crizotinib can be decreased when it is combined with Enzalutamide.
CrizotinibThe metabolism of Enzalutamide can be decreased when combined with Crizotinib.
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be decreased when it is combined with Enzalutamide.
CyclophosphamideThe serum concentration of Cyclophosphamide can be decreased when it is combined with Enzalutamide.
CyclosporineThe serum concentration of Cyclosporine can be decreased when it is combined with Enzalutamide.
CyclosporineThe metabolism of Enzalutamide can be decreased when combined with Cyclosporine.
CytarabineThe serum concentration of Cytarabine can be decreased when it is combined with Enzalutamide.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Enzalutamide.
DabrafenibThe serum concentration of Enzalutamide can be decreased when it is combined with Dabrafenib.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Enzalutamide.
DaclatasvirThe serum concentration of Daclatasvir can be decreased when it is combined with Enzalutamide.
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Enzalutamide.
DantroleneThe serum concentration of Dantrolene can be decreased when it is combined with Enzalutamide.
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Enzalutamide.
DapsoneThe serum concentration of Dapsone can be decreased when it is combined with Enzalutamide.
DarifenacinThe serum concentration of Darifenacin can be decreased when it is combined with Enzalutamide.
DarunavirThe serum concentration of Enzalutamide can be increased when it is combined with Darunavir.
DarunavirThe serum concentration of Darunavir can be decreased when it is combined with Enzalutamide.
DasabuvirThe serum concentration of Dasabuvir can be decreased when it is combined with Enzalutamide.
DasatinibThe serum concentration of Enzalutamide can be increased when it is combined with Dasatinib.
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Enzalutamide.
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Enzalutamide.
DeferasiroxThe serum concentration of Enzalutamide can be decreased when it is combined with Deferasirox.
DehydroepiandrosteroneThe serum concentration of Dehydroepiandrosterone can be decreased when it is combined with Enzalutamide.
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be decreased when it is combined with Enzalutamide.
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Enzalutamide.
DelavirdineThe metabolism of Enzalutamide can be decreased when combined with Delavirdine.
DesoximetasoneThe serum concentration of Desoximetasone can be decreased when it is combined with Enzalutamide.
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be decreased when it is combined with Enzalutamide.
DesvenlafaxineThe serum concentration of Desvenlafaxine can be decreased when it is combined with Enzalutamide.
DexamethasoneThe serum concentration of Enzalutamide can be decreased when it is combined with Dexamethasone.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Enzalutamide.
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be decreased when it is combined with Enzalutamide.
DextromethorphanThe serum concentration of Dextromethorphan can be decreased when it is combined with Enzalutamide.
DextropropoxypheneThe serum concentration of Dextropropoxyphene can be decreased when it is combined with Enzalutamide.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Enzalutamide.
DiclofenacThe serum concentration of Diclofenac can be decreased when it is combined with Enzalutamide.
DienogestThe serum concentration of Dienogest can be decreased when it is combined with Enzalutamide.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Enzalutamide.
DiflorasoneThe serum concentration of Diflorasone can be decreased when it is combined with Enzalutamide.
DifluocortoloneThe serum concentration of Difluocortolone can be decreased when it is combined with Enzalutamide.
DifluprednateThe serum concentration of Difluprednate can be decreased when it is combined with Enzalutamide.
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Enzalutamide.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Enzalutamide.
DihydrocodeineThe serum concentration of Dihydrocodeine can be decreased when it is combined with Enzalutamide.
DihydroergotamineThe serum concentration of Dihydroergotamine can be decreased when it is combined with Enzalutamide.
DihydroergotamineThe metabolism of Enzalutamide can be decreased when combined with Dihydroergotamine.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Enzalutamide.
DiltiazemThe metabolism of Enzalutamide can be decreased when combined with Diltiazem.
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Enzalutamide.
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Enzalutamide.
DisopyramideThe serum concentration of Disopyramide can be decreased when it is combined with Enzalutamide.
DisulfiramThe serum concentration of Disulfiram can be decreased when it is combined with Enzalutamide.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Enzalutamide.
DofetilideThe serum concentration of Dofetilide can be decreased when it is combined with Enzalutamide.
DolasetronThe serum concentration of Dolasetron can be decreased when it is combined with Enzalutamide.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Enzalutamide.
DonepezilThe serum concentration of Donepezil can be decreased when it is combined with Enzalutamide.
DorzolamideThe serum concentration of Dorzolamide can be decreased when it is combined with Enzalutamide.
DoxepinThe serum concentration of Doxepin can be decreased when it is combined with Enzalutamide.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Enzalutamide.
DoxycyclineThe metabolism of Enzalutamide can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Dronabinol can be decreased when it is combined with Enzalutamide.
DronedaroneThe serum concentration of Dronedarone can be decreased when it is combined with Enzalutamide.
DronedaroneThe metabolism of Enzalutamide can be decreased when combined with Dronedarone.
DutasterideThe serum concentration of Dutasteride can be decreased when it is combined with Enzalutamide.
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Enzalutamide.
EfavirenzThe serum concentration of Enzalutamide can be decreased when it is combined with Efavirenz.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Enzalutamide.
EliglustatThe serum concentration of Eliglustat can be decreased when it is combined with Enzalutamide.
ElvitegravirThe serum concentration of Elvitegravir can be decreased when it is combined with Enzalutamide.
EnalaprilThe serum concentration of Enalapril can be decreased when it is combined with Enzalutamide.
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Enzalutamide.
EplerenoneThe serum concentration of Eplerenone can be decreased when it is combined with Enzalutamide.
EquileninThe serum concentration of Equilenin can be decreased when it is combined with Enzalutamide.
EquilinThe serum concentration of Equilin can be decreased when it is combined with Enzalutamide.
ErgocalciferolThe serum concentration of Ergocalciferol can be decreased when it is combined with Enzalutamide.
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be decreased when it is combined with Enzalutamide.
ErgonovineThe serum concentration of Ergonovine can be decreased when it is combined with Enzalutamide.
ErgotamineThe serum concentration of Ergotamine can be decreased when it is combined with Enzalutamide.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Enzalutamide.
ErythromycinThe metabolism of Enzalutamide can be decreased when combined with Erythromycin.
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Enzalutamide.
EscitalopramThe serum concentration of Escitalopram can be decreased when it is combined with Enzalutamide.
Eslicarbazepine acetateThe serum concentration of Enzalutamide can be decreased when it is combined with Eslicarbazepine acetate.
EsomeprazoleThe serum concentration of Esomeprazole can be decreased when it is combined with Enzalutamide.
EstazolamThe serum concentration of Estazolam can be decreased when it is combined with Enzalutamide.
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Enzalutamide.
Estradiol valerate/DienogestThe serum concentration of Estradiol valerate/Dienogest can be decreased when it is combined with Enzalutamide.
EstramustineThe serum concentration of Estramustine can be decreased when it is combined with Enzalutamide.
EstriolThe serum concentration of Estriol can be increased when it is combined with Enzalutamide.
EstroneThe serum concentration of Estrone can be increased when it is combined with Enzalutamide.
Estrone sulfateThe serum concentration of Estrone sulfate can be decreased when it is combined with Enzalutamide.
EszopicloneThe serum concentration of Eszopiclone can be decreased when it is combined with Enzalutamide.
EthanolThe serum concentration of Ethanol can be decreased when it is combined with Enzalutamide.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Enzalutamide.
EthosuximideThe serum concentration of Ethosuximide can be decreased when it is combined with Enzalutamide.
EthylmorphineThe serum concentration of Ethylmorphine can be decreased when it is combined with Enzalutamide.
EtonogestrelThe serum concentration of Etonogestrel can be decreased when it is combined with Enzalutamide.
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Enzalutamide.
EtoricoxibThe serum concentration of Etoricoxib can be decreased when it is combined with Enzalutamide.
EtravirineThe serum concentration of Enzalutamide can be decreased when it is combined with Etravirine.
EverolimusThe serum concentration of Everolimus can be decreased when it is combined with Enzalutamide.
ExemestaneThe serum concentration of Exemestane can be decreased when it is combined with Enzalutamide.
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Enzalutamide.
FamciclovirThe serum concentration of Famciclovir can be decreased when it is combined with Enzalutamide.
FelbamateThe serum concentration of Felbamate can be decreased when it is combined with Enzalutamide.
FelodipineThe serum concentration of Felodipine can be decreased when it is combined with Enzalutamide.
FelodipineThe metabolism of Enzalutamide can be decreased when combined with Felodipine.
FenofibrateThe serum concentration of Fenofibrate can be decreased when it is combined with Enzalutamide.
FentanylThe serum concentration of Fentanyl can be decreased when it is combined with Enzalutamide.
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Enzalutamide.
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Enzalutamide.
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Enzalutamide.
FinasterideThe serum concentration of Finasteride can be decreased when it is combined with Enzalutamide.
FingolimodThe serum concentration of Fingolimod can be decreased when it is combined with Enzalutamide.
FlibanserinThe serum concentration of Flibanserin can be decreased when it is combined with Enzalutamide.
FluconazoleThe metabolism of Enzalutamide can be decreased when combined with Fluconazole.
FludrocortisoneThe serum concentration of Fludrocortisone can be decreased when it is combined with Enzalutamide.
FlumethasoneThe serum concentration of Flumethasone can be decreased when it is combined with Enzalutamide.
FlunisolideThe serum concentration of Flunisolide can be decreased when it is combined with Enzalutamide.
FlunitrazepamThe serum concentration of Flunitrazepam can be decreased when it is combined with Enzalutamide.
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be decreased when it is combined with Enzalutamide.
FluocinonideThe serum concentration of Fluocinonide can be decreased when it is combined with Enzalutamide.
FluocortoloneThe serum concentration of Fluocortolone can be decreased when it is combined with Enzalutamide.
FluorometholoneThe serum concentration of Fluorometholone can be decreased when it is combined with Enzalutamide.
FluoxetineThe serum concentration of Fluoxetine can be decreased when it is combined with Enzalutamide.
FluprednideneThe serum concentration of Fluprednidene can be decreased when it is combined with Enzalutamide.
FluprednisoloneThe serum concentration of Fluprednisolone can be decreased when it is combined with Enzalutamide.
FlurandrenolideThe serum concentration of Flurandrenolide can be decreased when it is combined with Enzalutamide.
FlurazepamThe serum concentration of Flurazepam can be decreased when it is combined with Enzalutamide.
FlutamideThe serum concentration of Flutamide can be decreased when it is combined with Enzalutamide.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Enzalutamide.
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be decreased when it is combined with Enzalutamide.
FluvastatinThe serum concentration of Fluvastatin can be decreased when it is combined with Enzalutamide.
FluvoxamineThe metabolism of Enzalutamide can be decreased when combined with Fluvoxamine.
FosamprenavirThe serum concentration of Fosamprenavir can be decreased when it is combined with Enzalutamide.
FosamprenavirThe metabolism of Enzalutamide can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Enzalutamide can be increased when it is combined with Fosaprepitant.
FosphenytoinThe serum concentration of Enzalutamide can be decreased when it is combined with Fosphenytoin.
FulvestrantThe serum concentration of Fulvestrant can be decreased when it is combined with Enzalutamide.
Fusidic AcidThe serum concentration of Enzalutamide can be increased when it is combined with Fusidic Acid.
GalantamineThe serum concentration of Galantamine can be decreased when it is combined with Enzalutamide.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Enzalutamide.
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Enzalutamide.
GemfibrozilThe serum concentration of Enzalutamide can be increased when it is combined with Gemfibrozil.
GemfibrozilThe serum concentration of Gemfibrozil can be decreased when it is combined with Enzalutamide.
GlipizideThe serum concentration of Glipizide can be decreased when it is combined with Enzalutamide.
GlyburideThe serum concentration of Glyburide can be decreased when it is combined with Enzalutamide.
GranisetronThe serum concentration of Granisetron can be decreased when it is combined with Enzalutamide.
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Enzalutamide.
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Enzalutamide.
GuanfacineThe serum concentration of Guanfacine can be decreased when it is combined with Enzalutamide.
HalofantrineThe serum concentration of Halofantrine can be decreased when it is combined with Enzalutamide.
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Enzalutamide.
HalothaneThe serum concentration of Halothane can be decreased when it is combined with Enzalutamide.
HexobarbitalThe serum concentration of Hexobarbital can be decreased when it is combined with Enzalutamide.
Histamine PhosphateThe serum concentration of Histamine Phosphate can be decreased when it is combined with Enzalutamide.
HydrocodoneThe serum concentration of Hydrocodone can be decreased when it is combined with Enzalutamide.
HydrocortisoneThe serum concentration of Hydrocortisone can be decreased when it is combined with Enzalutamide.
HydromorphoneThe serum concentration of Hydromorphone can be decreased when it is combined with Enzalutamide.
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be decreased when it is combined with Enzalutamide.
IbrutinibThe serum concentration of Ibrutinib can be decreased when it is combined with Enzalutamide.
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Enzalutamide.
IdelalisibThe serum concentration of Enzalutamide can be increased when it is combined with Idelalisib.
IdelalisibThe serum concentration of Idelalisib can be decreased when it is combined with Enzalutamide.
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be increased when Ifosfamide is used in combination with Enzalutamide.
IloperidoneThe serum concentration of Iloperidone can be decreased when it is combined with Enzalutamide.
ImatinibThe metabolism of Enzalutamide can be decreased when combined with Imatinib.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Enzalutamide.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Enzalutamide.
ImiquimodThe serum concentration of Imiquimod can be decreased when it is combined with Enzalutamide.
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Enzalutamide.
IndapamideThe serum concentration of Indapamide can be decreased when it is combined with Enzalutamide.
IndinavirThe serum concentration of Enzalutamide can be increased when it is combined with Indinavir.
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Enzalutamide.
Ipratropium bromideThe serum concentration of Ipratropium bromide can be decreased when it is combined with Enzalutamide.
IrbesartanThe metabolism of Enzalutamide can be decreased when combined with Irbesartan.
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be reduced when Irinotecan is used in combination with Enzalutamide resulting in a loss in efficacy.
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Enzalutamide resulting in a loss in efficacy.
IsavuconazoniumThe metabolism of Enzalutamide can be decreased when combined with Isavuconazonium.
Isosorbide DinitrateThe serum concentration of Isosorbide Dinitrate can be decreased when it is combined with Enzalutamide.
Isosorbide MononitrateThe serum concentration of Isosorbide Mononitrate can be decreased when it is combined with Enzalutamide.
IsradipineThe serum concentration of Isradipine can be decreased when it is combined with Enzalutamide.
IsradipineThe metabolism of Enzalutamide can be decreased when combined with Isradipine.
ItraconazoleThe serum concentration of Itraconazole can be decreased when it is combined with Enzalutamide.
ItraconazoleThe serum concentration of Enzalutamide can be increased when it is combined with Itraconazole.
IvabradineThe serum concentration of Ivabradine can be decreased when it is combined with Enzalutamide.
IvacaftorThe serum concentration of Enzalutamide can be increased when it is combined with Ivacaftor.
IvacaftorThe serum concentration of Ivacaftor can be decreased when it is combined with Enzalutamide.
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Enzalutamide.
IxabepiloneThe serum concentration of Ixabepilone can be decreased when it is combined with Enzalutamide.
IxazomibThe serum concentration of Ixazomib can be decreased when it is combined with Enzalutamide.
KetamineThe serum concentration of Ketamine can be decreased when it is combined with Enzalutamide.
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Enzalutamide.
KetobemidoneThe serum concentration of Ketobemidone can be decreased when it is combined with Enzalutamide.
KetoconazoleThe serum concentration of Enzalutamide can be increased when it is combined with Ketoconazole.
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Enzalutamide.
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Enzalutamide.
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Enzalutamide.
LapatinibThe serum concentration of Lapatinib can be decreased when it is combined with Enzalutamide.
LapatinibThe metabolism of Enzalutamide can be decreased when combined with Lapatinib.
LaquinimodThe serum concentration of Laquinimod can be decreased when it is combined with Enzalutamide.
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Enzalutamide.
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Enzalutamide.
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Enzalutamide.
LercanidipineThe serum concentration of Lercanidipine can be decreased when it is combined with Enzalutamide.
LetrozoleThe serum concentration of Letrozole can be decreased when it is combined with Enzalutamide.
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Enzalutamide.
LevobupivacaineThe serum concentration of Levobupivacaine can be decreased when it is combined with Enzalutamide.
LevocetirizineThe serum concentration of Levocetirizine can be decreased when it is combined with Enzalutamide.
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Enzalutamide.
Levomethadyl AcetateThe serum concentration of Levomethadyl Acetate can be decreased when it is combined with Enzalutamide.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Enzalutamide.
LevonorgestrelThe serum concentration of Levonorgestrel can be decreased when it is combined with Enzalutamide.
LevothyroxineThe serum concentration of Levothyroxine can be decreased when it is combined with Enzalutamide.
LidocaineThe serum concentration of Lidocaine can be decreased when it is combined with Enzalutamide.
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Enzalutamide.
LisurideThe serum concentration of Lisuride can be decreased when it is combined with Enzalutamide.
LomitapideThe serum concentration of Lomitapide can be decreased when it is combined with Enzalutamide.
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Enzalutamide.
LopinavirThe serum concentration of Enzalutamide can be increased when it is combined with Lopinavir.
LopinavirThe serum concentration of Lopinavir can be decreased when it is combined with Enzalutamide.
LoratadineThe serum concentration of Loratadine can be decreased when it is combined with Enzalutamide.
LorcaserinThe serum concentration of Lorcaserin can be decreased when it is combined with Enzalutamide.
LosartanThe serum concentration of Losartan can be increased when it is combined with Enzalutamide.
LosartanThe metabolism of Enzalutamide can be decreased when combined with Losartan.
LovastatinThe serum concentration of Lovastatin can be decreased when it is combined with Enzalutamide.
LovastatinThe metabolism of Enzalutamide can be decreased when combined with Lovastatin.
LuliconazoleThe serum concentration of Enzalutamide can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Enzalutamide can be increased when it is combined with Lumacaftor.
LumefantrineThe serum concentration of Lumefantrine can be decreased when it is combined with Enzalutamide.
LurasidoneThe serum concentration of Lurasidone can be decreased when it is combined with Enzalutamide.
MacitentanThe serum concentration of Macitentan can be decreased when it is combined with Enzalutamide.
MannitolThe serum concentration of Mannitol can be increased when it is combined with Enzalutamide.
MaravirocThe serum concentration of Maraviroc can be decreased when it is combined with Enzalutamide.
MebendazoleThe serum concentration of Mebendazole can be decreased when it is combined with Enzalutamide.
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Enzalutamide.
MedrysoneThe serum concentration of Medrysone can be decreased when it is combined with Enzalutamide.
MefloquineThe serum concentration of Mefloquine can be decreased when it is combined with Enzalutamide.
MelengestrolThe serum concentration of Melengestrol can be decreased when it is combined with Enzalutamide.
MeloxicamThe serum concentration of Meloxicam can be decreased when it is combined with Enzalutamide.
MethadoneThe serum concentration of Methadone can be decreased when it is combined with Enzalutamide.
MethaqualoneThe serum concentration of Methaqualone can be decreased when it is combined with Enzalutamide.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Enzalutamide.
MethoxsalenThe serum concentration of Methoxsalen can be decreased when it is combined with Enzalutamide.
MethoxyfluraneThe serum concentration of Methoxyflurane can be decreased when it is combined with Enzalutamide.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Enzalutamide.
MethyltestosteroneThe serum concentration of Methyltestosterone can be decreased when it is combined with Enzalutamide.
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Enzalutamide.
MetronidazoleThe serum concentration of Metronidazole can be decreased when it is combined with Enzalutamide.
MexiletineThe serum concentration of Mexiletine can be decreased when it is combined with Enzalutamide.
MianserinThe serum concentration of Mianserin can be decreased when it is combined with Enzalutamide.
MibefradilThe serum concentration of Mibefradil can be decreased when it is combined with Enzalutamide.
MiconazoleThe serum concentration of Miconazole can be decreased when it is combined with Enzalutamide.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Enzalutamide.
MifepristoneThe serum concentration of Mifepristone can be decreased when it is combined with Enzalutamide.
MifepristoneThe metabolism of Enzalutamide can be decreased when combined with Mifepristone.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Enzalutamide.
MirtazapineThe serum concentration of Mirtazapine can be decreased when it is combined with Enzalutamide.
MitotaneThe serum concentration of Enzalutamide can be decreased when it is combined with Mitotane.
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Enzalutamide.
ModafinilThe serum concentration of Enzalutamide can be decreased when it is combined with Modafinil.
MometasoneThe serum concentration of Mometasone can be decreased when it is combined with Enzalutamide.
MontelukastThe serum concentration of Montelukast can be decreased when it is combined with Enzalutamide.
MorphineThe serum concentration of Morphine can be increased when it is combined with Enzalutamide.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Enzalutamide.
NadololThe serum concentration of Nadolol can be increased when it is combined with Enzalutamide.
NafcillinThe serum concentration of Enzalutamide can be decreased when it is combined with Nafcillin.
NaloxegolThe serum concentration of Naloxegol can be decreased when it is combined with Enzalutamide.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Enzalutamide.
NateglinideThe serum concentration of Nateglinide can be decreased when it is combined with Enzalutamide.
NefazodoneThe serum concentration of Enzalutamide can be increased when it is combined with Nefazodone.
NefazodoneThe serum concentration of Nefazodone can be decreased when it is combined with Enzalutamide.
NelfinavirThe serum concentration of Enzalutamide can be increased when it is combined with Nelfinavir.
NetupitantThe serum concentration of Enzalutamide can be increased when it is combined with Netupitant.
NetupitantThe serum concentration of Netupitant can be decreased when it is combined with Enzalutamide.
NevirapineThe serum concentration of Enzalutamide can be decreased when it is combined with Nevirapine.
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Enzalutamide.
NicotineThe serum concentration of Nicotine can be decreased when it is combined with Enzalutamide.
NifedipineThe serum concentration of Nifedipine can be decreased when it is combined with Enzalutamide.
NilotinibThe serum concentration of Nilotinib can be decreased when it is combined with Enzalutamide.
NilotinibThe metabolism of Enzalutamide can be decreased when combined with Nilotinib.
NilvadipineThe serum concentration of Nilvadipine can be decreased when it is combined with Enzalutamide.
NimodipineThe serum concentration of Nimodipine can be decreased when it is combined with Enzalutamide.
NintedanibThe serum concentration of Nintedanib can be decreased when it is combined with Enzalutamide.
NisoldipineThe serum concentration of Nisoldipine can be decreased when it is combined with Enzalutamide.
NitrazepamThe serum concentration of Nitrazepam can be decreased when it is combined with Enzalutamide.
NitrendipineThe serum concentration of Nitrendipine can be decreased when it is combined with Enzalutamide.
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Enzalutamide.
NorethisteroneThe serum concentration of Norethisterone can be decreased when it is combined with Enzalutamide.
NorgestrelThe serum concentration of Norgestrel can be decreased when it is combined with Enzalutamide.
NortriptylineThe serum concentration of Nortriptyline can be decreased when it is combined with Enzalutamide.
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Enzalutamide.
OlaparibThe serum concentration of Olaparib can be decreased when it is combined with Enzalutamide.
OlaparibThe metabolism of Enzalutamide can be decreased when combined with Olaparib.
OlopatadineThe serum concentration of Olopatadine can be decreased when it is combined with Enzalutamide.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Enzalutamide.
OmeprazoleThe serum concentration of Omeprazole can be decreased when it is combined with Enzalutamide.
OndansetronThe serum concentration of Ondansetron can be decreased when it is combined with Enzalutamide.
OrphenadrineThe serum concentration of Orphenadrine can be decreased when it is combined with Enzalutamide.
OsimertinibThe serum concentration of Enzalutamide can be increased when it is combined with Osimertinib.
OsimertinibThe serum concentration of Osimertinib can be decreased when it is combined with Enzalutamide.
OspemifeneThe serum concentration of Ospemifene can be decreased when it is combined with Enzalutamide.
OxazepamThe serum concentration of Oxazepam can be decreased when it is combined with Enzalutamide.
OxybutyninThe serum concentration of Oxybutynin can be decreased when it is combined with Enzalutamide.
OxycodoneThe serum concentration of Oxycodone can be decreased when it is combined with Enzalutamide.
OxymorphoneThe serum concentration of Oxymorphone can be decreased when it is combined with Enzalutamide.
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Enzalutamide.
PalbociclibThe serum concentration of Enzalutamide can be increased when it is combined with Palbociclib.
PalbociclibThe serum concentration of Palbociclib can be decreased when it is combined with Enzalutamide.
PalonosetronThe serum concentration of Palonosetron can be decreased when it is combined with Enzalutamide.
PanobinostatThe serum concentration of Panobinostat can be decreased when it is combined with Enzalutamide.
PantoprazoleThe serum concentration of Pantoprazole can be decreased when it is combined with Enzalutamide.
ParamethadioneThe serum concentration of Paramethadione can be decreased when it is combined with Enzalutamide.
ParamethasoneThe serum concentration of Paramethasone can be decreased when it is combined with Enzalutamide.
ParecoxibThe serum concentration of Parecoxib can be decreased when it is combined with Enzalutamide.
ParicalcitolThe serum concentration of Paricalcitol can be decreased when it is combined with Enzalutamide.
ParitaprevirThe serum concentration of Paritaprevir can be decreased when it is combined with Enzalutamide.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Enzalutamide.
PentamidineThe serum concentration of Pentamidine can be decreased when it is combined with Enzalutamide.
PentobarbitalThe serum concentration of Enzalutamide can be decreased when it is combined with Pentobarbital.
PerampanelThe serum concentration of Perampanel can be decreased when it is combined with Enzalutamide.
PergolideThe serum concentration of Pergolide can be decreased when it is combined with Enzalutamide.
PerhexilineThe serum concentration of Perhexiline can be decreased when it is combined with Enzalutamide.
PermethrinThe serum concentration of Permethrin can be decreased when it is combined with Enzalutamide.
PerphenazineThe serum concentration of Perphenazine can be decreased when it is combined with Enzalutamide.
PethidineThe serum concentration of Pethidine can be decreased when it is combined with Enzalutamide.
PhenacetinThe serum concentration of Phenacetin can be decreased when it is combined with Enzalutamide.
PhenobarbitalThe serum concentration of Enzalutamide can be decreased when it is combined with Phenobarbital.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Enzalutamide.
PhenoxybenzamineThe serum concentration of Phenoxybenzamine can be decreased when it is combined with Enzalutamide.
PhenprocoumonThe serum concentration of Phenprocoumon can be decreased when it is combined with Enzalutamide.
PhenytoinThe serum concentration of Enzalutamide can be decreased when it is combined with Phenytoin.
PilocarpineThe serum concentration of Pilocarpine can be decreased when it is combined with Enzalutamide.
PimecrolimusThe serum concentration of Pimecrolimus can be decreased when it is combined with Enzalutamide.
PimozideThe serum concentration of Pimozide can be decreased when it is combined with Enzalutamide.
PinacidilThe serum concentration of Pinacidil can be decreased when it is combined with Enzalutamide.
PioglitazoneThe serum concentration of Pioglitazone can be decreased when it is combined with Enzalutamide.
PioglitazoneThe metabolism of Enzalutamide can be decreased when combined with Pioglitazone.
PipotiazineThe serum concentration of Pipotiazine can be decreased when it is combined with Enzalutamide.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Enzalutamide.
PodofiloxThe serum concentration of Podofilox can be decreased when it is combined with Enzalutamide.
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Enzalutamide.
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with Enzalutamide.
PosaconazoleThe serum concentration of Enzalutamide can be increased when it is combined with Posaconazole.
PosaconazoleThe serum concentration of Posaconazole can be decreased when it is combined with Enzalutamide.
PrasugrelThe serum concentration of Prasugrel can be decreased when it is combined with Enzalutamide.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Enzalutamide.
PrazepamThe serum concentration of Prazepam can be decreased when it is combined with Enzalutamide.
PraziquantelThe serum concentration of Praziquantel can be decreased when it is combined with Enzalutamide.
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Enzalutamide.
PrednicarbateThe serum concentration of Prednicarbate can be decreased when it is combined with Enzalutamide.
PrednisoloneThe serum concentration of Prednisolone can be decreased when it is combined with Enzalutamide.
PrednisoneThe serum concentration of Prednisone can be decreased when it is combined with Enzalutamide.
PregnenoloneThe serum concentration of Pregnenolone can be decreased when it is combined with Enzalutamide.
PrimaquineThe serum concentration of Primaquine can be decreased when it is combined with Enzalutamide.
PrimidoneThe serum concentration of Enzalutamide can be decreased when it is combined with Primidone.
ProchlorperazineThe serum concentration of Prochlorperazine can be decreased when it is combined with Enzalutamide.
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Enzalutamide.
ProguanilThe serum concentration of Proguanil can be decreased when it is combined with Enzalutamide.
PromazineThe serum concentration of Promazine can be decreased when it is combined with Enzalutamide.
PropafenoneThe serum concentration of Propafenone can be decreased when it is combined with Enzalutamide.
PropofolThe serum concentration of Propofol can be decreased when it is combined with Enzalutamide.
PropranololThe serum concentration of Propranolol can be increased when it is combined with Enzalutamide.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Enzalutamide.
PyrazinamideThe serum concentration of Pyrazinamide can be decreased when it is combined with Enzalutamide.
QuazepamThe serum concentration of Quazepam can be decreased when it is combined with Enzalutamide.
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Enzalutamide.
QuinacrineThe serum concentration of Quinacrine can be decreased when it is combined with Enzalutamide.
QuinidineThe serum concentration of Quinidine can be decreased when it is combined with Enzalutamide.
QuinineThe serum concentration of Quinine can be increased when it is combined with Enzalutamide.
QuinineThe metabolism of Enzalutamide can be decreased when combined with Quinine.
RabeprazoleThe serum concentration of Rabeprazole can be decreased when it is combined with Enzalutamide.
RabeprazoleThe metabolism of Enzalutamide can be decreased when combined with Rabeprazole.
RaloxifeneThe serum concentration of Raloxifene can be decreased when it is combined with Enzalutamide.
RamelteonThe serum concentration of Ramelteon can be decreased when it is combined with Enzalutamide.
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Enzalutamide.
RanolazineThe serum concentration of Ranolazine can be decreased when it is combined with Enzalutamide.
RanolazineThe metabolism of Enzalutamide can be decreased when combined with Ranolazine.
ReboxetineThe serum concentration of Reboxetine can be decreased when it is combined with Enzalutamide.
RegorafenibThe serum concentration of Regorafenib can be decreased when it is combined with Enzalutamide.
RepaglinideThe serum concentration of Repaglinide can be decreased when it is combined with Enzalutamide.
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Enzalutamide.
RetapamulinThe serum concentration of Retapamulin can be decreased when it is combined with Enzalutamide.
RifabutinThe serum concentration of Enzalutamide can be decreased when it is combined with Rifabutin.
RifampicinThe serum concentration of Enzalutamide can be decreased when it is combined with Rifampicin.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Enzalutamide.
RifapentineThe serum concentration of Enzalutamide can be decreased when it is combined with Rifapentine.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Enzalutamide.
RilpivirineThe serum concentration of Rilpivirine can be decreased when it is combined with Enzalutamide.
RimexoloneThe serum concentration of Rimexolone can be decreased when it is combined with Enzalutamide.
RimonabantThe serum concentration of Rimonabant can be decreased when it is combined with Enzalutamide.
RiociguatThe serum concentration of Riociguat can be decreased when it is combined with Enzalutamide.
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Enzalutamide.
RitonavirThe serum concentration of Enzalutamide can be increased when it is combined with Ritonavir.
RivaroxabanThe serum concentration of Rivaroxaban can be decreased when it is combined with Enzalutamide.
RofecoxibThe serum concentration of Rofecoxib can be decreased when it is combined with Enzalutamide.
RoflumilastThe serum concentration of Roflumilast can be decreased when it is combined with Enzalutamide.
RolapitantThe serum concentration of Rolapitant can be decreased when it is combined with Enzalutamide.
RomidepsinThe serum concentration of Romidepsin can be decreased when it is combined with Enzalutamide.
RopiniroleThe serum concentration of Ropinirole can be decreased when it is combined with Enzalutamide.
RopivacaineThe serum concentration of Ropivacaine can be decreased when it is combined with Enzalutamide.
RosiglitazoneThe metabolism of Enzalutamide can be decreased when combined with Rosiglitazone.
RosuvastatinThe serum concentration of Rosuvastatin can be decreased when it is combined with Enzalutamide.
RotigotineThe serum concentration of Rotigotine can be decreased when it is combined with Enzalutamide.
RoxithromycinThe serum concentration of Roxithromycin can be decreased when it is combined with Enzalutamide.
RuxolitinibThe serum concentration of Ruxolitinib can be decreased when it is combined with Enzalutamide.
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Enzalutamide.
SalmeterolThe serum concentration of Salmeterol can be decreased when it is combined with Enzalutamide.
SaquinavirThe serum concentration of Enzalutamide can be increased when it is combined with Saquinavir.
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Enzalutamide.
SecobarbitalThe serum concentration of Enzalutamide can be decreased when it is combined with Secobarbital.
SelegilineThe serum concentration of Selegiline can be decreased when it is combined with Enzalutamide.
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Enzalutamide.
SeratrodastThe serum concentration of Seratrodast can be decreased when it is combined with Enzalutamide.
SertindoleThe serum concentration of Sertindole can be decreased when it is combined with Enzalutamide.
SertralineThe serum concentration of Sertraline can be decreased when it is combined with Enzalutamide.
SevofluraneThe serum concentration of Sevoflurane can be decreased when it is combined with Enzalutamide.
SibutramineThe serum concentration of Sibutramine can be decreased when it is combined with Enzalutamide.
SildenafilThe serum concentration of Sildenafil can be decreased when it is combined with Enzalutamide.
SildenafilThe metabolism of Enzalutamide can be decreased when combined with Sildenafil.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Enzalutamide.
SiltuximabThe serum concentration of Enzalutamide can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Enzalutamide can be increased when it is combined with Simeprevir.
SimeprevirThe serum concentration of Simeprevir can be decreased when it is combined with Enzalutamide.
SimvastatinThe serum concentration of Simvastatin can be decreased when it is combined with Enzalutamide.
SirolimusThe serum concentration of Sirolimus can be decreased when it is combined with Enzalutamide.
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Enzalutamide.
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Enzalutamide.
SolifenacinThe serum concentration of Solifenacin can be decreased when it is combined with Enzalutamide.
SonidegibThe serum concentration of Sonidegib can be decreased when it is combined with Enzalutamide.
SorafenibThe serum concentration of Sorafenib can be decreased when it is combined with Enzalutamide.
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Enzalutamide.
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Enzalutamide.
SpiramycinThe serum concentration of Spiramycin can be decreased when it is combined with Enzalutamide.
St. John's WortThe serum concentration of Enzalutamide can be decreased when it is combined with St. John's Wort.
StiripentolThe serum concentration of Enzalutamide can be increased when it is combined with Stiripentol.
SufentanilThe serum concentration of Sufentanil can be decreased when it is combined with Enzalutamide.
SulfadiazineThe serum concentration of Sulfadiazine can be decreased when it is combined with Enzalutamide.
SulfamethoxazoleThe serum concentration of Sulfamethoxazole can be decreased when it is combined with Enzalutamide.
SulfamethoxazoleThe metabolism of Enzalutamide can be decreased when combined with Sulfamethoxazole.
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be decreased when it is combined with Enzalutamide.
SulfisoxazoleThe metabolism of Enzalutamide can be decreased when combined with Sulfisoxazole.
SunitinibThe serum concentration of Sunitinib can be decreased when it is combined with Enzalutamide.
SuvorexantThe serum concentration of Suvorexant can be decreased when it is combined with Enzalutamide.
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be decreased when it is combined with Enzalutamide.
Synthetic Conjugated Estrogens, BThe serum concentration of Synthetic Conjugated Estrogens, B can be decreased when it is combined with Enzalutamide.
TacrolimusThe serum concentration of Tacrolimus can be decreased when it is combined with Enzalutamide.
TadalafilThe serum concentration of Tadalafil can be decreased when it is combined with Enzalutamide.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Enzalutamide.
TamoxifenThe metabolism of Enzalutamide can be decreased when combined with Tamoxifen.
TamsulosinThe serum concentration of Tamsulosin can be decreased when it is combined with Enzalutamide.
TasimelteonThe serum concentration of Tasimelteon can be decreased when it is combined with Enzalutamide.
TasosartanThe serum concentration of Tasosartan can be decreased when it is combined with Enzalutamide.
Taurochenodeoxycholic acidThe serum concentration of Taurochenodeoxycholic acid can be decreased when it is combined with Enzalutamide.
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Enzalutamide.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Enzalutamide.
TelaprevirThe serum concentration of Enzalutamide can be increased when it is combined with Telaprevir.
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Enzalutamide.
TelithromycinThe serum concentration of Enzalutamide can be increased when it is combined with Telithromycin.
TelithromycinThe serum concentration of Telithromycin can be decreased when it is combined with Enzalutamide.
TemazepamThe serum concentration of Temazepam can be decreased when it is combined with Enzalutamide.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Enzalutamide.
TeniposideThe serum concentration of Teniposide can be decreased when it is combined with Enzalutamide.
TerbinafineThe serum concentration of Terbinafine can be decreased when it is combined with Enzalutamide.
TerfenadineThe serum concentration of Terfenadine can be decreased when it is combined with Enzalutamide.
TeriflunomideThe metabolism of Enzalutamide can be decreased when combined with Teriflunomide.
TesmilifeneThe serum concentration of Tesmilifene can be decreased when it is combined with Enzalutamide.
TestosteroneThe serum concentration of Testosterone can be decreased when it is combined with Enzalutamide.
TetracyclineThe serum concentration of Tetracycline can be decreased when it is combined with Enzalutamide.
TheophyllineThe serum concentration of Theophylline can be decreased when it is combined with Enzalutamide.
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Enzalutamide.
ThiotepaThe serum concentration of Thiotepa can be decreased when it is combined with Enzalutamide.
TiagabineThe serum concentration of Tiagabine can be decreased when it is combined with Enzalutamide.
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Enzalutamide resulting in a loss in efficacy.
TiclopidineThe serum concentration of Ticlopidine can be decreased when it is combined with Enzalutamide.
TiclopidineThe metabolism of Enzalutamide can be decreased when combined with Ticlopidine.
TimololThe serum concentration of Timolol can be increased when it is combined with Enzalutamide.
TinidazoleThe serum concentration of Tinidazole can be decreased when it is combined with Enzalutamide.
TiotropiumThe serum concentration of Tiotropium can be decreased when it is combined with Enzalutamide.
TipranavirThe serum concentration of Tipranavir can be decreased when it is combined with Enzalutamide.
TixocortolThe serum concentration of Tixocortol can be decreased when it is combined with Enzalutamide.
TocilizumabThe serum concentration of Enzalutamide can be decreased when it is combined with Tocilizumab.
TofacitinibThe serum concentration of Tofacitinib can be decreased when it is combined with Enzalutamide.
TolterodineThe serum concentration of Tolterodine can be decreased when it is combined with Enzalutamide.
TolvaptanThe serum concentration of Tolvaptan can be decreased when it is combined with Enzalutamide.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Enzalutamide.
ToremifeneThe serum concentration of Toremifene can be decreased when it is combined with Enzalutamide.
TrabectedinThe serum concentration of Trabectedin can be decreased when it is combined with Enzalutamide.
TramadolThe serum concentration of Tramadol can be decreased when it is combined with Enzalutamide.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Enzalutamide.
TrazodoneThe serum concentration of Trazodone can be decreased when it is combined with Enzalutamide.
TretinoinThe serum concentration of Tretinoin can be decreased when it is combined with Enzalutamide.
TriamcinoloneThe serum concentration of Triamcinolone can be decreased when it is combined with Enzalutamide.
TriazolamThe serum concentration of Triazolam can be decreased when it is combined with Enzalutamide.
TrimethadioneThe serum concentration of Trimethadione can be decreased when it is combined with Enzalutamide.
TrimethoprimThe serum concentration of Trimethoprim can be decreased when it is combined with Enzalutamide.
TrimethoprimThe metabolism of Enzalutamide can be decreased when combined with Trimethoprim.
TrimipramineThe serum concentration of Trimipramine can be decreased when it is combined with Enzalutamide.
TroglitazoneThe serum concentration of Troglitazone can be decreased when it is combined with Enzalutamide.
TroleandomycinThe serum concentration of Troleandomycin can be decreased when it is combined with Enzalutamide.
UdenafilThe serum concentration of Udenafil can be decreased when it is combined with Enzalutamide.
UlipristalThe serum concentration of Ulipristal can be decreased when it is combined with Enzalutamide.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Enzalutamide.
ValdecoxibThe serum concentration of Valdecoxib can be decreased when it is combined with Enzalutamide.
VandetanibThe serum concentration of Vandetanib can be decreased when it is combined with Enzalutamide.
VanoxerineThe serum concentration of Vanoxerine can be decreased when it is combined with Enzalutamide.
VardenafilThe serum concentration of Vardenafil can be decreased when it is combined with Enzalutamide.
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Enzalutamide.
VemurafenibThe serum concentration of Vemurafenib can be decreased when it is combined with Enzalutamide.
VenlafaxineThe metabolism of Enzalutamide can be decreased when combined with Venlafaxine.
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Enzalutamide.
VerapamilThe metabolism of Enzalutamide can be decreased when combined with Verapamil.
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Enzalutamide.
VicrivirocThe serum concentration of Vicriviroc can be decreased when it is combined with Enzalutamide.
VilanterolThe serum concentration of Vilanterol can be decreased when it is combined with Enzalutamide.
VilazodoneThe serum concentration of Vilazodone can be decreased when it is combined with Enzalutamide.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Enzalutamide.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Enzalutamide.
VindesineThe serum concentration of Vindesine can be decreased when it is combined with Enzalutamide.
VinorelbineThe serum concentration of Vinorelbine can be decreased when it is combined with Enzalutamide.
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Enzalutamide.
VorapaxarThe serum concentration of Vorapaxar can be decreased when it is combined with Enzalutamide.
VoriconazoleThe serum concentration of Enzalutamide can be increased when it is combined with Voriconazole.
VoriconazoleThe serum concentration of Voriconazole can be decreased when it is combined with Enzalutamide.
VortioxetineThe serum concentration of Vortioxetine can be decreased when it is combined with Enzalutamide.
WarfarinThe serum concentration of Warfarin can be decreased when it is combined with Enzalutamide.
YohimbineThe serum concentration of Yohimbine can be decreased when it is combined with Enzalutamide.
ZafirlukastThe serum concentration of Zafirlukast can be decreased when it is combined with Enzalutamide.
ZalcitabineThe serum concentration of Zalcitabine can be decreased when it is combined with Enzalutamide.
ZaleplonThe serum concentration of Zaleplon can be decreased when it is combined with Enzalutamide.
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Enzalutamide.
ZileutonThe serum concentration of Zileuton can be decreased when it is combined with Enzalutamide.
ZiprasidoneThe serum concentration of Ziprasidone can be decreased when it is combined with Enzalutamide.
ZiprasidoneThe metabolism of Enzalutamide can be decreased when combined with Ziprasidone.
ZolpidemThe serum concentration of Zolpidem can be decreased when it is combined with Enzalutamide.
ZomepiracThe serum concentration of Zomepirac can be decreased when it is combined with Enzalutamide.
ZonisamideThe serum concentration of Zonisamide can be decreased when it is combined with Enzalutamide.
ZopicloneThe serum concentration of Zopiclone can be decreased when it is combined with Enzalutamide.
ZuclopenthixolThe serum concentration of Zuclopenthixol can be decreased when it is combined with Enzalutamide.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Zinc ion binding
Specific Function:
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
Gene Name:
AR
Uniprot ID:
P10275
Molecular Weight:
98987.9 Da

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da

Carriers

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Toxic substance binding
Specific Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Gene Name:
ALB
Uniprot ID:
P02768
Molecular Weight:
69365.94 Da

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
Comments
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Drug created on June 04, 2013 23:12 / Updated on September 26, 2016 02:14