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Identification
NameLuliconazole
Accession NumberDB08933
TypeSmall Molecule
GroupsApproved
Description

Luliconazole is a topical antifungal agent that acts by unknown mechanisms but is postulated to involve altering the synthesis of fungi cell membranes. It was approved by the FDA (USA) in November 2013 and is marketed under the brand name Luzu. Luliconazole is also approved in Japan.

Structure
Thumb
SynonymsNot Available
External Identifiers
  • NND-502
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Luzucream10 mg/gtopicalMedicis Pharmaceutical Corp.2013-11-14Not applicableUs
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
LuliconPola Pharma
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIRE91AN4S8G
CAS number187164-19-8
WeightAverage: 354.27
Monoisotopic: 352.961495
Chemical FormulaC14H9Cl2N3S2
InChI KeyYTAOBBFIOAEMLL-REQDGWNSSA-N
InChI
InChI=1S/C14H9Cl2N3S2/c15-9-1-2-10(11(16)5-9)13-7-20-14(21-13)12(6-17)19-4-3-18-8-19/h1-5,8,13H,7H2/b14-12+/t13-/m0/s1
IUPAC Name
2-[(2E,4R)-4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-2-(1H-imidazol-1-yl)acetonitrile
SMILES
ClC1=CC(Cl)=C(C=C1)[C@@H]1CS\C(S1)=C(\C#N)N1C=CN=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as dichlorobenzenes. These are compounds containing a benzene with exactly two chlorine atoms attached to it.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassHalobenzenes
Direct ParentDichlorobenzenes
Alternative Parents
Substituents
  • 1,3-dichlorobenzene
  • Aryl chloride
  • Aryl halide
  • N-substituted imidazole
  • Azole
  • Heteroaromatic compound
  • Dithiolane
  • 1,3-dithiolane
  • Imidazole
  • Azacycle
  • Organoheterocyclic compound
  • Carbonitrile
  • Nitrile
  • Organonitrogen compound
  • Organic nitrogen compound
  • Organochloride
  • Cyanide
  • Hydrocarbon derivative
  • Organohalogen compound
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationLuliconazole is indicated in adults aged 18 years and older for the topical treatment of fungal infections caused by Trichophyton rubrum and Epidermophyton floccosum, specifically tinea pedis, cruris, and corporis.
PharmacodynamicsLuliconazole kills the organisms Trichophyton rubrum and Epidermophyton floccosum, most likely by altering their fungal cell membranes.
Mechanism of actionThe exact mechanism of action for luliconazole's anti-fungal activity is still not known, but luliconazole is thought to inhibit the enzyme lanosterol demethylase. Lanosterol demethylase is needed for the synthesis of ergosterol, which is a major component of the fungus cell membranes.
Related Articles
AbsorptionAlthough luliconazole is administered topically, clinical studies have shown that after the first dose in patients with tina pedis, a maximum plasma concentration of 0.40 ± 0.76 ng/mL (mean ± SD) occurred in 16.9 ± 9.39 hours (mean ± SD).
Volume of distribution

The volume of distribution was not quantified.

Protein bindingPlasma protein binding of luliconazole is >99%.
Metabolism

The metabolism of luliconazole has yet to be determined.

Route of eliminationThe route of elimination of luliconazole has yet to be determined.
Half lifeThe half life of luliconazole has yet to be determined.
Clearance

The clearance of luliconazole has yet to be determined.

ToxicityIn clinical trials, no serious toxicity was reported, only local irritation (mild contact dermatitis and cellulitis) at the site of application was found.
Affected organisms
  • Fungi
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal AbsorptionNot AvailableNot Available
Blood Brain BarrierNot AvailableNot Available
Caco-2 permeableNot AvailableNot Available
P-glycoprotein substrateNot AvailableNot Available
P-glycoprotein inhibitor INot AvailableNot Available
P-glycoprotein inhibitor IINot AvailableNot Available
Renal organic cation transporterNot AvailableNot Available
CYP450 2C9 substrateNot AvailableNot Available
CYP450 2D6 substrateNot AvailableNot Available
CYP450 3A4 substrateNot AvailableNot Available
CYP450 1A2 substrateNot AvailableNot Available
CYP450 2C9 inhibitorNot AvailableNot Available
CYP450 2D6 inhibitorNot AvailableNot Available
CYP450 2C19 inhibitorNot AvailableNot Available
CYP450 3A4 inhibitorNot AvailableNot Available
CYP450 inhibitory promiscuityNot AvailableNot Available
Ames testNot AvailableNot Available
CarcinogenicityNot AvailableNot Available
BiodegradationNot AvailableNot Available
Rat acute toxicityNot AvailableNot applicable
hERG inhibition (predictor I)Not AvailableNot Available
hERG inhibition (predictor II)Not AvailableNot Available
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
Creamtopical10 mg/g
PricesNot Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5900488 No1996-07-052016-07-05Us
US8980931 No2014-04-282034-04-28Us
US9012484 No2013-09-062033-09-06Us
US9199977 No2013-09-062033-09-06Us
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.0659 mg/mLALOGPS
logP4.27ALOGPS
logP4.07ChemAxon
logS-3.7ALOGPS
pKa (Strongest Basic)6.34ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area41.61 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity101 m3·mol-1ChemAxon
Polarizability33.65 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

Niwano Y, Kuzuhara N, Kodama H, Yoshida M, Miyazaki T, Yamaguchi H: In vitro and in vivo antidermatophyte activities of NND-502, a novel optically active imidazole antimycotic agent. Antimicrob Agents Chemother. 1998 Apr;42(4):967-70.

General References
  1. Niwano Y, Kuzuhara N, Kodama H, Yoshida M, Miyazaki T, Yamaguchi H: In vitro and in vivo antidermatophyte activities of NND-502, a novel optically active imidazole antimycotic agent. Antimicrob Agents Chemother. 1998 Apr;42(4):967-70. [PubMed:9559824 ]
  2. Uchida K, Nishiyama Y, Yamaguchi H: In vitro antifungal activity of luliconazole (NND-502), a novel imidazole antifungal agent. J Infect Chemother. 2004 Aug;10(4):216-9. [PubMed:15365862 ]
External Links
ATC CodesD01AC18
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelDownload (199 KB)
MSDSDownload (567 KB)
Interactions
Drug Interactions
Drug
AlfentanilThe serum concentration of Alfentanil can be increased when it is combined with Luliconazole.
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Luliconazole.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Luliconazole.
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Luliconazole.
AminophyllineThe serum concentration of Aminophylline can be increased when it is combined with Luliconazole.
AmiodaroneThe serum concentration of Amiodarone can be increased when it is combined with Luliconazole.
AmlodipineThe serum concentration of Amlodipine can be increased when it is combined with Luliconazole.
AprepitantThe serum concentration of Aprepitant can be increased when it is combined with Luliconazole.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Luliconazole.
ArmodafinilThe serum concentration of Armodafinil can be increased when it is combined with Luliconazole.
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Luliconazole.
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Luliconazole.
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Luliconazole.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Luliconazole.
BenzphetamineThe serum concentration of Benzphetamine can be increased when it is combined with Luliconazole.
BisoprololThe serum concentration of Bisoprolol can be increased when it is combined with Luliconazole.
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Luliconazole.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Luliconazole.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Luliconazole.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Luliconazole.
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Luliconazole.
BuprenorphineThe serum concentration of Buprenorphine can be increased when it is combined with Luliconazole.
BuspironeThe serum concentration of Buspirone can be increased when it is combined with Luliconazole.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Luliconazole.
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Luliconazole.
CalcitriolThe serum concentration of Calcitriol can be increased when it is combined with Luliconazole.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Luliconazole.
CarisoprodolThe serum concentration of Carisoprodol can be increased when it is combined with Luliconazole.
CeritinibThe serum concentration of Ceritinib can be increased when it is combined with Luliconazole.
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be increased when it is combined with Luliconazole.
ChloroquineThe serum concentration of Chloroquine can be increased when it is combined with Luliconazole.
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Luliconazole.
CinacalcetThe serum concentration of Cinacalcet can be increased when it is combined with Luliconazole.
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Luliconazole.
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Luliconazole.
ClarithromycinThe serum concentration of Clarithromycin can be increased when it is combined with Luliconazole.
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Luliconazole.
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Luliconazole.
ClonazepamThe serum concentration of Clonazepam can be increased when it is combined with Luliconazole.
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Luliconazole.
ClorazepateThe serum concentration of Clorazepate can be increased when it is combined with Luliconazole.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Luliconazole.
CocaineThe serum concentration of Cocaine can be increased when it is combined with Luliconazole.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Luliconazole.
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Luliconazole.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Luliconazole.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Luliconazole.
Cyproterone acetateThe serum concentration of Cyproterone acetate can be increased when it is combined with Luliconazole.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Luliconazole.
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Luliconazole.
DantroleneThe serum concentration of Dantrolene can be increased when it is combined with Luliconazole.
DapsoneThe serum concentration of Dapsone can be increased when it is combined with Luliconazole.
DarifenacinThe serum concentration of Darifenacin can be increased when it is combined with Luliconazole.
DarunavirThe serum concentration of Darunavir can be increased when it is combined with Luliconazole.
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Luliconazole.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Luliconazole.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Luliconazole.
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Luliconazole.
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Luliconazole.
DisopyramideThe serum concentration of Disopyramide can be increased when it is combined with Luliconazole.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Luliconazole.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Luliconazole.
DoxazosinThe serum concentration of Doxazosin can be increased when it is combined with Luliconazole.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Luliconazole.
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Luliconazole.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Luliconazole.
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Luliconazole.
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Luliconazole.
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Luliconazole.
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Luliconazole.
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Luliconazole.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Luliconazole.
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Luliconazole.
EscitalopramThe serum concentration of Escitalopram can be increased when it is combined with Luliconazole.
EszopicloneThe serum concentration of Eszopiclone can be increased when it is combined with Luliconazole.
EthosuximideThe serum concentration of Ethosuximide can be increased when it is combined with Luliconazole.
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Luliconazole.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Luliconazole.
FelbamateThe serum concentration of Felbamate can be increased when it is combined with Luliconazole.
FelodipineThe serum concentration of Felodipine can be increased when it is combined with Luliconazole.
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Luliconazole.
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Luliconazole.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Luliconazole.
FlunisolideThe serum concentration of Flunisolide can be increased when it is combined with Luliconazole.
FlurazepamThe serum concentration of Flurazepam can be increased when it is combined with Luliconazole.
FlutamideThe serum concentration of Flutamide can be increased when it is combined with Luliconazole.
FosaprepitantThe serum concentration of Fosaprepitant can be increased when it is combined with Luliconazole.
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Luliconazole.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Luliconazole.
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Luliconazole.
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Luliconazole.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Luliconazole.
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be increased when it is combined with Luliconazole.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Luliconazole.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Luliconazole.
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Luliconazole.
IsavuconazoniumThe serum concentration of Isavuconazonium can be increased when it is combined with Luliconazole.
IsosorbideThe serum concentration of Isosorbide can be increased when it is combined with Luliconazole.
Isosorbide DinitrateThe serum concentration of Isosorbide Dinitrate can be increased when it is combined with Luliconazole.
Isosorbide MononitrateThe serum concentration of Isosorbide Mononitrate can be increased when it is combined with Luliconazole.
IsradipineThe serum concentration of Isradipine can be increased when it is combined with Luliconazole.
ItraconazoleThe serum concentration of Itraconazole can be increased when it is combined with Luliconazole.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Luliconazole.
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Luliconazole.
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Luliconazole.
KetamineThe serum concentration of Ketamine can be increased when it is combined with Luliconazole.
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Luliconazole.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Luliconazole.
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Luliconazole.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Luliconazole.
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Luliconazole.
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Luliconazole.
MacitentanThe serum concentration of MACITENTAN can be increased when it is combined with Luliconazole.
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Luliconazole.
MefloquineThe serum concentration of Mefloquine can be increased when it is combined with Luliconazole.
MethadoneThe serum concentration of Methadone can be increased when it is combined with Luliconazole.
MethsuximideThe serum concentration of Methsuximide can be increased when it is combined with Luliconazole.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Luliconazole.
MifepristoneThe serum concentration of Mifepristone can be increased when it is combined with Luliconazole.
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Luliconazole.
MoclobemideThe serum concentration of Moclobemide can be increased when it is combined with Luliconazole.
ModafinilThe serum concentration of Modafinil can be increased when it is combined with Luliconazole.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Luliconazole.
NateglinideThe serum concentration of Nateglinide can be increased when it is combined with Luliconazole.
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Luliconazole.
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Luliconazole.
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Luliconazole.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Luliconazole.
NilutamideThe serum concentration of Nilutamide can be increased when it is combined with Luliconazole.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Luliconazole.
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Luliconazole.
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Luliconazole.
OxycodoneThe serum concentration of Oxycodone can be increased when it is combined with Luliconazole.
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Luliconazole.
PalbociclibThe serum concentration of Palbociclib can be increased when it is combined with Luliconazole.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Luliconazole.
PantoprazoleThe serum concentration of Pantoprazole can be increased when it is combined with Luliconazole.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Luliconazole.
PentamidineThe serum concentration of Pentamidine can be increased when it is combined with Luliconazole.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Luliconazole.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Luliconazole.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Luliconazole.
PipotiazineThe serum concentration of Pipotiazine can be increased when it is combined with Luliconazole.
PraziquantelThe serum concentration of Praziquantel can be increased when it is combined with Luliconazole.
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Luliconazole.
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Luliconazole.
QuinineThe serum concentration of Quinine can be increased when it is combined with Luliconazole.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Luliconazole.
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Luliconazole.
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Luliconazole.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Luliconazole.
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Luliconazole.
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Luliconazole.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Luliconazole.
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Luliconazole.
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Luliconazole.
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Luliconazole.
SolifenacinThe serum concentration of Solifenacin can be increased when it is combined with Luliconazole.
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Luliconazole.
SpiramycinThe serum concentration of Spiramycin can be increased when it is combined with Luliconazole.
StiripentolThe serum concentration of Stiripentol can be increased when it is combined with Luliconazole.
SufentanilThe serum concentration of Sufentanil can be increased when it is combined with Luliconazole.
SunitinibThe serum concentration of Sunitinib can be increased when it is combined with Luliconazole.
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Luliconazole.
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Luliconazole.
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Luliconazole.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Luliconazole.
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Luliconazole.
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Luliconazole.
TelithromycinThe serum concentration of Telithromycin can be increased when it is combined with Luliconazole.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Luliconazole.
TeniposideThe serum concentration of Teniposide can be increased when it is combined with Luliconazole.
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Luliconazole.
TiagabineThe serum concentration of Tiagabine can be increased when it is combined with Luliconazole.
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Luliconazole.
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Luliconazole.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Luliconazole.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Luliconazole.
Trastuzumab emtansineThe serum concentration of ado-trastuzumab emtansine can be increased when it is combined with Luliconazole.
TrazodoneThe serum concentration of Trazodone can be increased when it is combined with Luliconazole.
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Luliconazole.
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Luliconazole.
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Luliconazole.
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Luliconazole.
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Luliconazole.
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Luliconazole.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Luliconazole.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Luliconazole.
VinorelbineThe serum concentration of Vinorelbine can be increased when it is combined with Luliconazole.
VoriconazoleThe serum concentration of Voriconazole can be increased when it is combined with Luliconazole.
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Luliconazole.
ZonisamideThe serum concentration of Zonisamide can be increased when it is combined with Luliconazole.
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Luliconazole.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Yeast
Pharmacological action
yes
Actions
inhibitor
General Function:
Sterol 14-demethylase activity
Specific Function:
Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
Gene Name:
ERG11
Uniprot ID:
P10613
Molecular Weight:
60674.965 Da
References
  1. Niwano Y, Koga H, Kodama H, Kanai K, Miyazaki T, Yamaguchi H: Inhibition of sterol 14 alpha-demethylation of Candida albicans with NND-502, a novel optically active imidazole antimycotic agent. Med Mycol. 1999 Oct;37(5):351-5. [PubMed:10520160 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
no
Actions
inhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
Kind
Protein
Organism
Human
Pharmacological action
no
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
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Drug created on December 29, 2013 15:57 / Updated on August 24, 2016 01:53