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Identification
NameLuliconazole
Accession NumberDB08933
TypeSmall Molecule
GroupsApproved
DescriptionLuliconazole is a topical antifungal agent that acts by unknown mechanisms but is postulated to involve altering the synthesis of fungi cell membranes. It was approved by the FDA (USA) in November 2013 and is marketed under the brand name Luzu. Luliconazole is also approved in Japan.
Structure
Thumb
SynonymsNot Available
External Identifiers
  • NND-502
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Luzucream10 mg/gtopicalMedicis Pharmaceutical Corp.2013-11-14Not applicableUs
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
LuliconPola Pharma
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIRE91AN4S8G
CAS number187164-19-8
WeightAverage: 354.27
Monoisotopic: 352.961495
Chemical FormulaC14H9Cl2N3S2
InChI KeyYTAOBBFIOAEMLL-REQDGWNSSA-N
InChI
InChI=1S/C14H9Cl2N3S2/c15-9-1-2-10(11(16)5-9)13-7-20-14(21-13)12(6-17)19-4-3-18-8-19/h1-5,8,13H,7H2/b14-12+/t13-/m0/s1
IUPAC Name
2-[(2E,4R)-4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-2-(1H-imidazol-1-yl)acetonitrile
SMILES
ClC1=CC(Cl)=C(C=C1)[C@@H]1CS\C(S1)=C(\C#N)N1C=CN=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as dichlorobenzenes. These are compounds containing a benzene with exactly two chlorine atoms attached to it.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassHalobenzenes
Direct ParentDichlorobenzenes
Alternative Parents
Substituents
  • 1,3-dichlorobenzene
  • Aryl chloride
  • Aryl halide
  • N-substituted imidazole
  • Azole
  • Heteroaromatic compound
  • Dithiolane
  • 1,3-dithiolane
  • Imidazole
  • Azacycle
  • Organoheterocyclic compound
  • Carbonitrile
  • Nitrile
  • Organonitrogen compound
  • Organic nitrogen compound
  • Organochloride
  • Cyanide
  • Hydrocarbon derivative
  • Organohalogen compound
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationLuliconazole is indicated in adults aged 18 years and older for the topical treatment of fungal infections caused by Trichophyton rubrum and Epidermophyton floccosum, specifically tinea pedis, cruris, and corporis.
PharmacodynamicsLuliconazole kills the organisms Trichophyton rubrum and Epidermophyton floccosum, most likely by altering their fungal cell membranes.
Mechanism of actionThe exact mechanism of action for luliconazole's anti-fungal activity is still not known, but luliconazole is thought to inhibit the enzyme lanosterol demethylase. Lanosterol demethylase is needed for the synthesis of ergosterol, which is a major component of the fungus cell membranes.
Related Articles
AbsorptionAlthough luliconazole is administered topically, clinical studies have shown that after the first dose in patients with tina pedis, a maximum plasma concentration of 0.40 ± 0.76 ng/mL (mean ± SD) occurred in 16.9 ± 9.39 hours (mean ± SD).
Volume of distribution

The volume of distribution was not quantified.

Protein bindingPlasma protein binding of luliconazole is >99%.
Metabolism

The metabolism of luliconazole has yet to be determined.

Route of eliminationThe route of elimination of luliconazole has yet to be determined.
Half lifeThe half life of luliconazole has yet to be determined.
Clearance

The clearance of luliconazole has yet to be determined.

ToxicityIn clinical trials, no serious toxicity was reported, only local irritation (mild contact dermatitis and cellulitis) at the site of application was found.
Affected organisms
  • Fungi
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal AbsorptionNot AvailableNot Available
Blood Brain BarrierNot AvailableNot Available
Caco-2 permeableNot AvailableNot Available
P-glycoprotein substrateNot AvailableNot Available
P-glycoprotein inhibitor INot AvailableNot Available
P-glycoprotein inhibitor IINot AvailableNot Available
Renal organic cation transporterNot AvailableNot Available
CYP450 2C9 substrateNot AvailableNot Available
CYP450 2D6 substrateNot AvailableNot Available
CYP450 3A4 substrateNot AvailableNot Available
CYP450 1A2 substrateNot AvailableNot Available
CYP450 2C9 inhibitorNot AvailableNot Available
CYP450 2D6 inhibitorNot AvailableNot Available
CYP450 2C19 inhibitorNot AvailableNot Available
CYP450 3A4 inhibitorNot AvailableNot Available
CYP450 inhibitory promiscuityNot AvailableNot Available
Ames testNot AvailableNot Available
CarcinogenicityNot AvailableNot Available
BiodegradationNot AvailableNot Available
Rat acute toxicityNot AvailableNot applicable
hERG inhibition (predictor I)Not AvailableNot Available
hERG inhibition (predictor II)Not AvailableNot Available
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
Creamtopical10 mg/g
PricesNot Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5900488 No1996-07-052016-07-05Us
US8980931 No2014-04-282034-04-28Us
US9012484 No2013-09-062033-09-06Us
US9199977 No2013-09-062033-09-06Us
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.0659 mg/mLALOGPS
logP4.27ALOGPS
logP4.07ChemAxon
logS-3.7ALOGPS
pKa (Strongest Basic)6.34ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area41.61 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity101 m3·mol-1ChemAxon
Polarizability33.65 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

Niwano Y, Kuzuhara N, Kodama H, Yoshida M, Miyazaki T, Yamaguchi H: In vitro and in vivo antidermatophyte activities of NND-502, a novel optically active imidazole antimycotic agent. Antimicrob Agents Chemother. 1998 Apr;42(4):967-70.

General References
  1. Niwano Y, Kuzuhara N, Kodama H, Yoshida M, Miyazaki T, Yamaguchi H: In vitro and in vivo antidermatophyte activities of NND-502, a novel optically active imidazole antimycotic agent. Antimicrob Agents Chemother. 1998 Apr;42(4):967-70. [PubMed:9559824 ]
  2. Uchida K, Nishiyama Y, Yamaguchi H: In vitro antifungal activity of luliconazole (NND-502), a novel imidazole antifungal agent. J Infect Chemother. 2004 Aug;10(4):216-9. [PubMed:15365862 ]
External Links
ATC CodesD01AC18
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelDownload (199 KB)
MSDSDownload (567 KB)
Interactions
Drug Interactions
Drug
AbirateroneThe serum concentration of Abiraterone can be increased when it is combined with Luliconazole.
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Luliconazole.
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Luliconazole.
AdinazolamThe serum concentration of Adinazolam can be increased when it is combined with Luliconazole.
AlbendazoleThe serum concentration of Albendazole can be increased when it is combined with Luliconazole.
AlclometasoneThe serum concentration of Alclometasone can be increased when it is combined with Luliconazole.
AlfentanilThe serum concentration of Alfentanil can be increased when it is combined with Luliconazole.
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Luliconazole.
AliskirenThe serum concentration of Aliskiren can be increased when it is combined with Luliconazole.
AllylestrenolThe serum concentration of Allylestrenol can be increased when it is combined with Luliconazole.
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Luliconazole.
AlogliptinThe serum concentration of Alogliptin can be increased when it is combined with Luliconazole.
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Luliconazole.
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Luliconazole.
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Luliconazole.
AmbroxolThe serum concentration of Ambroxol can be increased when it is combined with Luliconazole.
AminophenazoneThe serum concentration of Aminophenazone can be increased when it is combined with Luliconazole.
AminophyllineThe serum concentration of Aminophylline can be increased when it is combined with Luliconazole.
AmiodaroneThe serum concentration of Amiodarone can be increased when it is combined with Luliconazole.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Luliconazole.
AmlodipineThe serum concentration of Amlodipine can be increased when it is combined with Luliconazole.
AmoxicillinThe serum concentration of Amoxicillin can be increased when it is combined with Luliconazole.
AmprenavirThe serum concentration of Amprenavir can be increased when it is combined with Luliconazole.
AntipyrineThe serum concentration of Antipyrine can be increased when it is combined with Luliconazole.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Luliconazole.
ApremilastThe serum concentration of Apremilast can be increased when it is combined with Luliconazole.
AprepitantThe serum concentration of Aprepitant can be increased when it is combined with Luliconazole.
ArformoterolThe serum concentration of Arformoterol can be increased when it is combined with Luliconazole.
ArgatrobanThe serum concentration of Argatroban can be increased when it is combined with Luliconazole.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Luliconazole.
ArtemetherThe serum concentration of Artemether can be increased when it is combined with Luliconazole.
AsenapineThe serum concentration of Asenapine can be increased when it is combined with Luliconazole.
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Luliconazole.
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Luliconazole.
AtomoxetineThe serum concentration of Atomoxetine can be increased when it is combined with Luliconazole.
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Luliconazole.
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Luliconazole.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Luliconazole.
AzelastineThe serum concentration of Azelastine can be increased when it is combined with Luliconazole.
AzithromycinThe serum concentration of Azithromycin can be increased when it is combined with Luliconazole.
BanoxantroneThe serum concentration of Banoxantrone can be increased when it is combined with Luliconazole.
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Luliconazole.
BenzatropineThe serum concentration of Benzatropine can be increased when it is combined with Luliconazole.
BenzphetamineThe serum concentration of Benzphetamine can be increased when it is combined with Luliconazole.
Benzyl alcoholThe serum concentration of Benzyl alcohol can be increased when it is combined with Luliconazole.
BexaroteneThe serum concentration of Bexarotene can be increased when it is combined with Luliconazole.
BezafibrateThe serum concentration of Bezafibrate can be increased when it is combined with Luliconazole.
BicalutamideThe serum concentration of Bicalutamide can be increased when it is combined with Luliconazole.
BisoprololThe serum concentration of Bisoprolol can be increased when it is combined with Luliconazole.
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Luliconazole.
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Luliconazole.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Luliconazole.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Luliconazole.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Luliconazole.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Luliconazole.
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Luliconazole.
BromazepamThe serum concentration of Bromazepam can be increased when it is combined with Luliconazole.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Luliconazole.
BrompheniramineThe serum concentration of Brompheniramine can be increased when it is combined with Luliconazole.
BudesonideThe metabolism of Budesonide can be decreased when combined with Luliconazole.
BupivacaineThe serum concentration of Bupivacaine can be increased when it is combined with Luliconazole.
BuprenorphineThe serum concentration of Buprenorphine can be increased when it is combined with Luliconazole.
BupropionThe serum concentration of Bupropion can be increased when it is combined with Luliconazole.
BuspironeThe serum concentration of Buspirone can be increased when it is combined with Luliconazole.
BusulfanThe serum concentration of Busulfan can be increased when it is combined with Luliconazole.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Luliconazole.
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Luliconazole.
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Luliconazole.
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Luliconazole.
CalcitriolThe serum concentration of Calcitriol can be increased when it is combined with Luliconazole.
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Luliconazole.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Luliconazole.
CarbinoxamineThe serum concentration of Carbinoxamine can be increased when it is combined with Luliconazole.
CariprazineThe serum concentration of Cariprazine can be increased when it is combined with Luliconazole.
CarisoprodolThe serum concentration of Carisoprodol can be increased when it is combined with Luliconazole.
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Luliconazole.
CelecoxibThe serum concentration of Celecoxib can be increased when it is combined with Luliconazole.
CeliprololThe serum concentration of Celiprolol can be increased when it is combined with Luliconazole.
CephalexinThe serum concentration of Cephalexin can be increased when it is combined with Luliconazole.
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Luliconazole.
CevimelineThe serum concentration of Cevimeline can be increased when it is combined with Luliconazole.
Chenodeoxycholic acidThe serum concentration of Chenodeoxycholic acid can be increased when it is combined with Luliconazole.
ChloramphenicolThe serum concentration of Chloramphenicol can be increased when it is combined with Luliconazole.
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be increased when it is combined with Luliconazole.
ChloroquineThe serum concentration of Chloroquine can be increased when it is combined with Luliconazole.
ChlorphenamineThe serum concentration of Chlorphenamine can be increased when it is combined with Luliconazole.
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Luliconazole.
ChlorpropamideThe serum concentration of Chlorpropamide can be increased when it is combined with Luliconazole.
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be increased when it is combined with Luliconazole.
CholecalciferolThe serum concentration of Cholecalciferol can be increased when it is combined with Luliconazole.
CiclesonideThe serum concentration of Ciclesonide can be increased when it is combined with Luliconazole.
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Luliconazole.
CinacalcetThe serum concentration of Cinacalcet can be increased when it is combined with Luliconazole.
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Luliconazole.
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Luliconazole.
ClarithromycinThe serum concentration of Clarithromycin can be increased when it is combined with Luliconazole.
ClindamycinThe serum concentration of Clindamycin can be increased when it is combined with Luliconazole.
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Luliconazole.
ClofazimineThe serum concentration of Clofazimine can be increased when it is combined with Luliconazole.
ClofibrateThe serum concentration of Clofibrate can be increased when it is combined with Luliconazole.
clomethiazoleThe serum concentration of clomethiazole can be increased when it is combined with Luliconazole.
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Luliconazole.
ClonazepamThe serum concentration of Clonazepam can be increased when it is combined with Luliconazole.
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Luliconazole.
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Luliconazole.
ClorazepateThe serum concentration of Clorazepate can be increased when it is combined with Luliconazole.
ClotiazepamThe serum concentration of Clotiazepam can be increased when it is combined with Luliconazole.
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Luliconazole.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Luliconazole.
CocaineThe serum concentration of Cocaine can be increased when it is combined with Luliconazole.
CodeineThe serum concentration of Codeine can be increased when it is combined with Luliconazole.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Luliconazole.
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Luliconazole.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Luliconazole.
Cortisone acetateThe serum concentration of Cortisone acetate can be increased when it is combined with Luliconazole.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Luliconazole.
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Luliconazole.
CyclophosphamideThe serum concentration of Cyclophosphamide can be increased when it is combined with Luliconazole.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Luliconazole.
CytarabineThe serum concentration of Cytarabine can be increased when it is combined with Luliconazole.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Luliconazole.
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Luliconazole.
DantroleneThe serum concentration of Dantrolene can be increased when it is combined with Luliconazole.
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Luliconazole.
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Luliconazole.
DapsoneThe serum concentration of Dapsone can be increased when it is combined with Luliconazole.
DarifenacinThe serum concentration of Darifenacin can be increased when it is combined with Luliconazole.
DarunavirThe serum concentration of Darunavir can be increased when it is combined with Luliconazole.
DasabuvirThe serum concentration of Dasabuvir can be increased when it is combined with Luliconazole.
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Luliconazole.
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Luliconazole.
DehydroepiandrosteroneThe serum concentration of Dehydroepiandrosterone can be increased when it is combined with Luliconazole.
DelavirdineThe serum concentration of Delavirdine can be increased when it is combined with Luliconazole.
DesipramineThe serum concentration of Desipramine can be increased when it is combined with Luliconazole.
DesvenlafaxineThe serum concentration of Desvenlafaxine can be increased when it is combined with Luliconazole.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Luliconazole.
DextromethorphanThe serum concentration of Dextromethorphan can be increased when it is combined with Luliconazole.
DextropropoxypheneThe serum concentration of Dextropropoxyphene can be increased when it is combined with Luliconazole.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Luliconazole.
DiclofenacThe serum concentration of Diclofenac can be increased when it is combined with Luliconazole.
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Luliconazole.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Luliconazole.
DihydrocodeineThe serum concentration of Dihydrocodeine can be increased when it is combined with Luliconazole.
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Luliconazole.
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Luliconazole.
DiphenhydramineThe serum concentration of Diphenhydramine can be increased when it is combined with Luliconazole.
DisopyramideThe serum concentration of Disopyramide can be increased when it is combined with Luliconazole.
DisulfiramThe serum concentration of Disulfiram can be increased when it is combined with Luliconazole.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Luliconazole.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Luliconazole.
DolasetronThe serum concentration of Dolasetron can be increased when it is combined with Luliconazole.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Luliconazole.
DonepezilThe serum concentration of Donepezil can be increased when it is combined with Luliconazole.
DopamineThe serum concentration of Dopamine can be increased when it is combined with Luliconazole.
DorzolamideThe serum concentration of Dorzolamide can be increased when it is combined with Luliconazole.
DoxazosinThe serum concentration of Doxazosin can be increased when it is combined with Luliconazole.
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Luliconazole.
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Luliconazole.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Luliconazole.
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Luliconazole.
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Luliconazole.
EfavirenzThe serum concentration of Efavirenz can be increased when it is combined with Luliconazole.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Luliconazole.
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Luliconazole.
ElvitegravirThe serum concentration of Elvitegravir can be increased when it is combined with Luliconazole.
EnalaprilThe serum concentration of Enalapril can be increased when it is combined with Luliconazole.
EnfuvirtideThe serum concentration of Enfuvirtide can be increased when it is combined with Luliconazole.
EnzalutamideThe serum concentration of Enzalutamide can be increased when it is combined with Luliconazole.
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Luliconazole.
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Luliconazole.
ErgocalciferolThe serum concentration of Ergocalciferol can be increased when it is combined with Luliconazole.
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Luliconazole.
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Luliconazole.
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Luliconazole.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Luliconazole.
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Luliconazole.
EscitalopramThe serum concentration of Escitalopram can be increased when it is combined with Luliconazole.
EsomeprazoleThe serum concentration of Esomeprazole can be increased when it is combined with Luliconazole.
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Luliconazole.
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Luliconazole.
Estradiol valerate/DienogestThe serum concentration of Estradiol valerate/Dienogest can be increased when it is combined with Luliconazole.
EstramustineThe serum concentration of Estramustine can be increased when it is combined with Luliconazole.
EstroneThe serum concentration of Estrone can be increased when it is combined with Luliconazole.
Estrone sulfateThe serum concentration of Estrone sulfate can be increased when it is combined with Luliconazole.
EszopicloneThe serum concentration of Eszopiclone can be increased when it is combined with Luliconazole.
EthanolThe serum concentration of Ethanol can be increased when it is combined with Luliconazole.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Luliconazole.
EthosuximideThe serum concentration of Ethosuximide can be increased when it is combined with Luliconazole.
EthylmorphineThe serum concentration of Ethylmorphine can be increased when it is combined with Luliconazole.
EtonogestrelThe serum concentration of Etonogestrel can be increased when it is combined with Luliconazole.
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Luliconazole.
EtoricoxibThe serum concentration of Etoricoxib can be increased when it is combined with Luliconazole.
EtravirineThe serum concentration of Etravirine can be increased when it is combined with Luliconazole.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Luliconazole.
ExemestaneThe serum concentration of Exemestane can be increased when it is combined with Luliconazole.
FamciclovirThe serum concentration of Famciclovir can be increased when it is combined with Luliconazole.
FamotidineThe serum concentration of Famotidine can be increased when it is combined with Luliconazole.
FelbamateThe serum concentration of Felbamate can be increased when it is combined with Luliconazole.
FelodipineThe serum concentration of Felodipine can be increased when it is combined with Luliconazole.
FenofibrateThe serum concentration of Fenofibrate can be increased when it is combined with Luliconazole.
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Luliconazole.
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Luliconazole.
FinasterideThe serum concentration of Finasteride can be increased when it is combined with Luliconazole.
FingolimodThe serum concentration of Fingolimod can be increased when it is combined with Luliconazole.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Luliconazole.
FlunisolideThe serum concentration of Flunisolide can be increased when it is combined with Luliconazole.
FlunitrazepamThe serum concentration of Flunitrazepam can be increased when it is combined with Luliconazole.
FluorometholoneThe serum concentration of Fluorometholone can be increased when it is combined with Luliconazole.
FluoxetineThe serum concentration of Fluoxetine can be increased when it is combined with Luliconazole.
FlurazepamThe serum concentration of Flurazepam can be increased when it is combined with Luliconazole.
FlutamideThe serum concentration of Flutamide can be increased when it is combined with Luliconazole.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Luliconazole.
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Luliconazole.
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Luliconazole.
FormoterolThe serum concentration of Formoterol can be increased when it is combined with Luliconazole.
FosamprenavirThe serum concentration of Fosamprenavir can be increased when it is combined with Luliconazole.
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Luliconazole.
FulvestrantThe serum concentration of Fulvestrant can be increased when it is combined with Luliconazole.
GalantamineThe serum concentration of Galantamine can be increased when it is combined with Luliconazole.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Luliconazole.
GemfibrozilThe serum concentration of Gemfibrozil can be increased when it is combined with Luliconazole.
GliclazideThe serum concentration of Gliclazide can be increased when it is combined with Luliconazole.
GlipizideThe serum concentration of Glipizide can be increased when it is combined with Luliconazole.
GlucosamineThe serum concentration of Glucosamine can be increased when it is combined with Luliconazole.
GlyburideThe serum concentration of Glyburide can be increased when it is combined with Luliconazole.
GranisetronThe serum concentration of Granisetron can be increased when it is combined with Luliconazole.
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Luliconazole.
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Luliconazole.
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Luliconazole.
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Luliconazole.
HalothaneThe serum concentration of Halothane can be increased when it is combined with Luliconazole.
HexobarbitalThe serum concentration of Hexobarbital can be increased when it is combined with Luliconazole.
Histamine PhosphateThe serum concentration of Histamine Phosphate can be increased when it is combined with Luliconazole.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Luliconazole.
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Luliconazole.
HydromorphoneThe serum concentration of Hydromorphone can be increased when it is combined with Luliconazole.
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be increased when it is combined with Luliconazole.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Luliconazole.
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Luliconazole.
IfosfamideThe serum concentration of Ifosfamide can be increased when it is combined with Luliconazole.
IloperidoneThe serum concentration of Iloperidone can be increased when it is combined with Luliconazole.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Luliconazole.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Luliconazole.
ImiquimodThe serum concentration of Imiquimod can be increased when it is combined with Luliconazole.
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Luliconazole.
IndapamideThe serum concentration of Indapamide can be increased when it is combined with Luliconazole.
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Luliconazole.
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Luliconazole.
Ipratropium bromideThe serum concentration of Ipratropium bromide can be increased when it is combined with Luliconazole.
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Luliconazole.
IsavuconazoniumThe serum concentration of Isavuconazonium can be increased when it is combined with Luliconazole.
Isosorbide DinitrateThe serum concentration of Isosorbide Dinitrate can be increased when it is combined with Luliconazole.
Isosorbide MononitrateThe serum concentration of Isosorbide Mononitrate can be increased when it is combined with Luliconazole.
IsradipineThe serum concentration of Isradipine can be increased when it is combined with Luliconazole.
ItraconazoleThe serum concentration of Itraconazole can be increased when it is combined with Luliconazole.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Luliconazole.
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Luliconazole.
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Luliconazole.
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Luliconazole.
IxazomibThe serum concentration of Ixazomib can be increased when it is combined with Luliconazole.
KetamineThe serum concentration of Ketamine can be increased when it is combined with Luliconazole.
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Luliconazole.
KetobemidoneThe serum concentration of Ketobemidone can be increased when it is combined with Luliconazole.
KetoconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Luliconazole.
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Luliconazole.
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Luliconazole.
LaquinimodThe serum concentration of Laquinimod can be increased when it is combined with Luliconazole.
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Luliconazole.
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Luliconazole.
LetrozoleThe serum concentration of Letrozole can be increased when it is combined with Luliconazole.
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Luliconazole.
LevocetirizineThe serum concentration of Levocetirizine can be increased when it is combined with Luliconazole.
Levomethadyl AcetateThe serum concentration of Levomethadyl Acetate can be increased when it is combined with Luliconazole.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Luliconazole.
LevonorgestrelThe serum concentration of Levonorgestrel can be increased when it is combined with Luliconazole.
LevothyroxineThe serum concentration of Levothyroxine can be increased when it is combined with Luliconazole.
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Luliconazole.
LisurideThe serum concentration of Lisuride can be increased when it is combined with Luliconazole.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Luliconazole.
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Luliconazole.
LopinavirThe serum concentration of Lopinavir can be increased when it is combined with Luliconazole.
LoratadineThe serum concentration of Loratadine can be increased when it is combined with Luliconazole.
LorcaserinThe serum concentration of Lorcaserin can be increased when it is combined with Luliconazole.
LosartanThe serum concentration of Losartan can be increased when it is combined with Luliconazole.
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Luliconazole.
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Luliconazole.
LumiracoxibThe serum concentration of Lumiracoxib can be increased when it is combined with Luliconazole.
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Luliconazole.
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Luliconazole.
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Luliconazole.
MebendazoleThe serum concentration of Mebendazole can be increased when it is combined with Luliconazole.
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Luliconazole.
MefloquineThe serum concentration of Mefloquine can be increased when it is combined with Luliconazole.
MelatoninThe serum concentration of Melatonin can be increased when it is combined with Luliconazole.
MeloxicamThe serum concentration of Meloxicam can be increased when it is combined with Luliconazole.
MephenytoinThe serum concentration of Mephenytoin can be increased when it is combined with Luliconazole.
MeprobamateThe serum concentration of Meprobamate can be increased when it is combined with Luliconazole.
MethadoneThe serum concentration of Methadone can be increased when it is combined with Luliconazole.
MethaqualoneThe serum concentration of Methaqualone can be increased when it is combined with Luliconazole.
MethoxsalenThe serum concentration of Methoxsalen can be increased when it is combined with Luliconazole.
MethoxyfluraneThe serum concentration of Methoxyflurane can be increased when it is combined with Luliconazole.
MethsuximideThe serum concentration of Methsuximide can be increased when it is combined with Luliconazole.
MethylphenobarbitalThe serum concentration of Methylphenobarbital can be increased when it is combined with Luliconazole.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Luliconazole.
MethyltestosteroneThe serum concentration of Methyltestosterone can be increased when it is combined with Luliconazole.
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Luliconazole.
MetronidazoleThe serum concentration of Metronidazole can be increased when it is combined with Luliconazole.
MexiletineThe serum concentration of Mexiletine can be increased when it is combined with Luliconazole.
MianserinThe serum concentration of Mianserin can be increased when it is combined with Luliconazole.
MibefradilThe serum concentration of Mibefradil can be increased when it is combined with Luliconazole.
MiconazoleThe serum concentration of Miconazole can be increased when it is combined with Luliconazole.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Luliconazole.
MifepristoneThe serum concentration of Mifepristone can be increased when it is combined with Luliconazole.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Luliconazole.
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Luliconazole.
MoclobemideThe serum concentration of Moclobemide can be increased when it is combined with Luliconazole.
ModafinilThe serum concentration of Modafinil can be increased when it is combined with Luliconazole.
MontelukastThe serum concentration of Montelukast can be increased when it is combined with Luliconazole.
MorphineThe serum concentration of Morphine can be increased when it is combined with Luliconazole.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Luliconazole.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Luliconazole.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Luliconazole.
NateglinideThe serum concentration of Nateglinide can be increased when it is combined with Luliconazole.
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Luliconazole.
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Luliconazole.
NevirapineThe serum concentration of Nevirapine can be increased when it is combined with Luliconazole.
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Luliconazole.
NicotineThe serum concentration of Nicotine can be increased when it is combined with Luliconazole.
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Luliconazole.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Luliconazole.
NilutamideThe serum concentration of Nilutamide can be increased when it is combined with Luliconazole.
NilvadipineThe serum concentration of Nilvadipine can be increased when it is combined with Luliconazole.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Luliconazole.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Luliconazole.
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Luliconazole.
NitrazepamThe serum concentration of Nitrazepam can be increased when it is combined with Luliconazole.
NitrendipineThe serum concentration of Nitrendipine can be increased when it is combined with Luliconazole.
NorethisteroneThe serum concentration of Norethisterone can be increased when it is combined with Luliconazole.
NorgestrelThe serum concentration of Norgestrel can be increased when it is combined with Luliconazole.
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Luliconazole.
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Luliconazole.
OlopatadineThe serum concentration of Olopatadine can be increased when it is combined with Luliconazole.
OmeprazoleThe serum concentration of Omeprazole can be increased when it is combined with Luliconazole.
OndansetronThe serum concentration of Ondansetron can be increased when it is combined with Luliconazole.
OrphenadrineThe serum concentration of Orphenadrine can be increased when it is combined with Luliconazole.
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Luliconazole.
OxazepamThe serum concentration of Oxazepam can be increased when it is combined with Luliconazole.
OxiconazoleThe serum concentration of Oxiconazole can be increased when it is combined with Luliconazole.
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Luliconazole.
OxycodoneThe serum concentration of Oxycodone can be increased when it is combined with Luliconazole.
OxymorphoneThe serum concentration of Oxymorphone can be increased when it is combined with Luliconazole.
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Luliconazole.
PalbociclibThe serum concentration of Palbociclib can be increased when it is combined with Luliconazole.
PalonosetronThe serum concentration of Palonosetron can be increased when it is combined with Luliconazole.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Luliconazole.
PantoprazoleThe serum concentration of Pantoprazole can be increased when it is combined with Luliconazole.
ParamethadioneThe serum concentration of Paramethadione can be increased when it is combined with Luliconazole.
ParamethasoneThe serum concentration of Paramethasone can be increased when it is combined with Luliconazole.
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Luliconazole.
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Luliconazole.
ParitaprevirThe serum concentration of Paritaprevir can be increased when it is combined with Luliconazole.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Luliconazole.
PentamidineThe serum concentration of Pentamidine can be increased when it is combined with Luliconazole.
PentobarbitalThe serum concentration of Pentobarbital can be increased when it is combined with Luliconazole.
PerampanelThe serum concentration of Perampanel can be increased when it is combined with Luliconazole.
PergolideThe serum concentration of Pergolide can be increased when it is combined with Luliconazole.
PerhexilineThe serum concentration of Perhexiline can be increased when it is combined with Luliconazole.
PermethrinThe serum concentration of Permethrin can be increased when it is combined with Luliconazole.
PerphenazineThe serum concentration of Perphenazine can be increased when it is combined with Luliconazole.
PethidineThe serum concentration of Pethidine can be increased when it is combined with Luliconazole.
PhenacetinThe serum concentration of Phenacetin can be increased when it is combined with Luliconazole.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Luliconazole.
PhenoxybenzamineThe serum concentration of Phenoxybenzamine can be increased when it is combined with Luliconazole.
PhenprocoumonThe serum concentration of Phenprocoumon can be increased when it is combined with Luliconazole.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Luliconazole.
PilocarpineThe serum concentration of Pilocarpine can be increased when it is combined with Luliconazole.
PimecrolimusThe serum concentration of Pimecrolimus can be increased when it is combined with Luliconazole.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Luliconazole.
PinacidilThe serum concentration of Pinacidil can be increased when it is combined with Luliconazole.
PioglitazoneThe serum concentration of Pioglitazone can be increased when it is combined with Luliconazole.
PipotiazineThe serum concentration of Pipotiazine can be increased when it is combined with Luliconazole.
PodofiloxThe serum concentration of Podofilox can be increased when it is combined with Luliconazole.
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Luliconazole.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Luliconazole.
PosaconazoleThe serum concentration of Posaconazole can be increased when it is combined with Luliconazole.
PrasugrelThe serum concentration of Prasugrel can be increased when it is combined with Luliconazole.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Luliconazole.
PrazepamThe serum concentration of Prazepam can be increased when it is combined with Luliconazole.
PraziquantelThe serum concentration of Praziquantel can be increased when it is combined with Luliconazole.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Luliconazole.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Luliconazole.
PrimaquineThe serum concentration of Primaquine can be increased when it is combined with Luliconazole.
PrimidoneThe serum concentration of Primidone can be increased when it is combined with Luliconazole.
ProchlorperazineThe serum concentration of Prochlorperazine can be increased when it is combined with Luliconazole.
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Luliconazole.
ProguanilThe serum concentration of Proguanil can be increased when it is combined with Luliconazole.
PromazineThe serum concentration of Promazine can be increased when it is combined with Luliconazole.
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Luliconazole.
PropofolThe serum concentration of Propofol can be increased when it is combined with Luliconazole.
PropranololThe serum concentration of Propranolol can be increased when it is combined with Luliconazole.
PyrazinamideThe serum concentration of Pyrazinamide can be increased when it is combined with Luliconazole.
QuazepamThe serum concentration of Quazepam can be increased when it is combined with Luliconazole.
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Luliconazole.
QuinacrineThe serum concentration of Quinacrine can be increased when it is combined with Luliconazole.
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Luliconazole.
QuinineThe serum concentration of Quinine can be increased when it is combined with Luliconazole.
RabeprazoleThe serum concentration of Rabeprazole can be increased when it is combined with Luliconazole.
RaloxifeneThe serum concentration of Raloxifene can be increased when it is combined with Luliconazole.
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Luliconazole.
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Luliconazole.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Luliconazole.
ReboxetineThe serum concentration of Reboxetine can be increased when it is combined with Luliconazole.
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Luliconazole.
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Luliconazole.
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Luliconazole.
RifabutinThe serum concentration of Rifabutin can be increased when it is combined with Luliconazole.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Luliconazole.
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Luliconazole.
RimonabantThe serum concentration of Rimonabant can be increased when it is combined with Luliconazole.
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Luliconazole.
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Luliconazole.
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Luliconazole.
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Luliconazole.
RofecoxibThe serum concentration of Rofecoxib can be increased when it is combined with Luliconazole.
RolapitantThe serum concentration of Rolapitant can be increased when it is combined with Luliconazole.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Luliconazole.
RopiniroleThe serum concentration of Ropinirole can be increased when it is combined with Luliconazole.
RopivacaineThe serum concentration of Ropivacaine can be increased when it is combined with Luliconazole.
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Luliconazole.
RotigotineThe serum concentration of Rotigotine can be increased when it is combined with Luliconazole.
RoxithromycinThe serum concentration of Roxithromycin can be increased when it is combined with Luliconazole.
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Luliconazole.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Luliconazole.
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Luliconazole.
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Luliconazole.
SelegilineThe serum concentration of Selegiline can be increased when it is combined with Luliconazole.
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Luliconazole.
SeratrodastThe serum concentration of Seratrodast can be increased when it is combined with Luliconazole.
SertindoleThe serum concentration of Sertindole can be increased when it is combined with Luliconazole.
SertralineThe serum concentration of Sertraline can be increased when it is combined with Luliconazole.
SevofluraneThe serum concentration of Sevoflurane can be increased when it is combined with Luliconazole.
SibutramineThe serum concentration of Sibutramine can be increased when it is combined with Luliconazole.
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Luliconazole.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Luliconazole.
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Luliconazole.
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Luliconazole.
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Luliconazole.
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Luliconazole.
SolifenacinThe serum concentration of Solifenacin can be increased when it is combined with Luliconazole.
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Luliconazole.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Luliconazole.
SpiramycinThe serum concentration of Spiramycin can be increased when it is combined with Luliconazole.
SufentanilThe serum concentration of Sufentanil can be increased when it is combined with Luliconazole.
SulfadiazineThe serum concentration of Sulfadiazine can be increased when it is combined with Luliconazole.
SulfamethoxazoleThe serum concentration of Sulfamethoxazole can be increased when it is combined with Luliconazole.
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be increased when it is combined with Luliconazole.
SunitinibThe serum concentration of Sunitinib can be increased when it is combined with Luliconazole.
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Luliconazole.
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be increased when it is combined with Luliconazole.
Synthetic Conjugated Estrogens, BThe serum concentration of Synthetic Conjugated Estrogens, B can be increased when it is combined with Luliconazole.
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Luliconazole.
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Luliconazole.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Luliconazole.
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Luliconazole.
TapentadolThe serum concentration of Tapentadol can be increased when it is combined with Luliconazole.
TasosartanThe serum concentration of Tasosartan can be increased when it is combined with Luliconazole.
Taurochenodeoxycholic acidThe serum concentration of Taurochenodeoxycholic acid can be increased when it is combined with Luliconazole.
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Luliconazole.
TelithromycinThe serum concentration of Telithromycin can be increased when it is combined with Luliconazole.
TemazepamThe serum concentration of Temazepam can be increased when it is combined with Luliconazole.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Luliconazole.
TeniposideThe serum concentration of Teniposide can be increased when it is combined with Luliconazole.
TerbinafineThe serum concentration of Terbinafine can be increased when it is combined with Luliconazole.
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Luliconazole.
TesmilifeneThe serum concentration of Tesmilifene can be increased when it is combined with Luliconazole.
TestosteroneThe serum concentration of Testosterone can be increased when it is combined with Luliconazole.
TetracyclineThe serum concentration of Tetracycline can be increased when it is combined with Luliconazole.
ThalidomideThe serum concentration of Thalidomide can be increased when it is combined with Luliconazole.
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Luliconazole.
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Luliconazole.
ThiotepaThe serum concentration of Thiotepa can be increased when it is combined with Luliconazole.
TiagabineThe serum concentration of Tiagabine can be increased when it is combined with Luliconazole.
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Luliconazole.
TiclopidineThe serum concentration of Ticlopidine can be increased when it is combined with Luliconazole.
TimololThe serum concentration of Timolol can be increased when it is combined with Luliconazole.
TinidazoleThe serum concentration of Tinidazole can be increased when it is combined with Luliconazole.
TiotropiumThe serum concentration of Tiotropium can be increased when it is combined with Luliconazole.
TipranavirThe serum concentration of Tipranavir can be increased when it is combined with Luliconazole.
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Luliconazole.
TolbutamideThe serum concentration of Tolbutamide can be increased when it is combined with Luliconazole.
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Luliconazole.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Luliconazole.
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Luliconazole.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Luliconazole.
TramadolThe serum concentration of Tramadol can be increased when it is combined with Luliconazole.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Luliconazole.
TrazodoneThe serum concentration of Trazodone can be increased when it is combined with Luliconazole.
TretinoinThe serum concentration of Tretinoin can be increased when it is combined with Luliconazole.
TriamcinoloneThe serum concentration of Triamcinolone can be increased when it is combined with Luliconazole.
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Luliconazole.
TrimethadioneThe serum concentration of Trimethadione can be increased when it is combined with Luliconazole.
TrimethoprimThe serum concentration of Trimethoprim can be increased when it is combined with Luliconazole.
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Luliconazole.
TroglitazoneThe serum concentration of Troglitazone can be increased when it is combined with Luliconazole.
TroleandomycinThe serum concentration of Troleandomycin can be increased when it is combined with Luliconazole.
UdenafilThe serum concentration of Udenafil can be increased when it is combined with Luliconazole.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Luliconazole.
ValdecoxibThe serum concentration of Valdecoxib can be increased when it is combined with Luliconazole.
Valproic AcidThe serum concentration of Valproic Acid can be increased when it is combined with Luliconazole.
VandetanibThe serum concentration of Vandetanib can be increased when it is combined with Luliconazole.
VanoxerineThe serum concentration of Vanoxerine can be increased when it is combined with Luliconazole.
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Luliconazole.
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Luliconazole.
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Luliconazole.
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Luliconazole.
VicrivirocThe serum concentration of Vicriviroc can be increased when it is combined with Luliconazole.
VilanterolThe serum concentration of Vilanterol can be increased when it is combined with Luliconazole.
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Luliconazole.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Luliconazole.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Luliconazole.
VindesineThe serum concentration of Vindesine can be increased when it is combined with Luliconazole.
VinorelbineThe serum concentration of Vinorelbine can be increased when it is combined with Luliconazole.
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Luliconazole.
VoriconazoleThe serum concentration of Voriconazole can be increased when it is combined with Luliconazole.
VortioxetineThe serum concentration of Vortioxetine can be increased when it is combined with Luliconazole.
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Luliconazole.
YohimbineThe serum concentration of Yohimbine can be increased when it is combined with Luliconazole.
ZafirlukastThe serum concentration of Zafirlukast can be increased when it is combined with Luliconazole.
ZalcitabineThe serum concentration of Zalcitabine can be increased when it is combined with Luliconazole.
ZaleplonThe serum concentration of Zaleplon can be increased when it is combined with Luliconazole.
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Luliconazole.
ZileutonThe serum concentration of Zileuton can be increased when it is combined with Luliconazole.
ZiprasidoneThe serum concentration of Ziprasidone can be increased when it is combined with Luliconazole.
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Luliconazole.
ZomepiracThe serum concentration of Zomepirac can be increased when it is combined with Luliconazole.
ZonisamideThe serum concentration of Zonisamide can be increased when it is combined with Luliconazole.
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Luliconazole.
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Luliconazole.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Yeast
Pharmacological action
yes
Actions
inhibitor
General Function:
Sterol 14-demethylase activity
Specific Function:
Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
Gene Name:
ERG11
Uniprot ID:
P10613
Molecular Weight:
60674.965 Da
References
  1. Niwano Y, Koga H, Kodama H, Kanai K, Miyazaki T, Yamaguchi H: Inhibition of sterol 14 alpha-demethylation of Candida albicans with NND-502, a novel optically active imidazole antimycotic agent. Med Mycol. 1999 Oct;37(5):351-5. [PubMed:10520160 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
no
Actions
inhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
Kind
Protein
Organism
Human
Pharmacological action
no
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
Comments
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Drug created on December 29, 2013 15:57 / Updated on October 01, 2016 02:24