Fusafungine

Identification

Generic Name
Fusafungine
DrugBank Accession Number
DB08965
Background

Fusafungine is an antibiotic from Fusarium lateririum, and is used for the treatment of respiratory infections.

Type
Small Molecule
Groups
Approved, Withdrawn
Structure
Weight
Average: 639.8204
Monoisotopic: 639.409480437
Chemical Formula
C33H57N3O9
Synonyms
  • Fusafungina
  • Fusafungine

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcenocoumarolThe risk or severity of bleeding can be increased when Fusafungine is combined with Acenocoumarol.
AmbroxolThe risk or severity of methemoglobinemia can be increased when Fusafungine is combined with Ambroxol.
ArticaineThe risk or severity of methemoglobinemia can be increased when Fusafungine is combined with Articaine.
BCG vaccineThe therapeutic efficacy of BCG vaccine can be decreased when used in combination with Fusafungine.
BenzocaineThe risk or severity of methemoglobinemia can be increased when Fusafungine is combined with Benzocaine.
Food Interactions
Not Available

Products

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Categories

ATC Codes
R02AB03 — Fusafungine
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as cyclic depsipeptides. These are natural or synthetic compounds having sequences of amino and hydroxy carboxylic acid residues (usually α-amino and α-hydroxy acids) connected in a ring. The residues are commonly but not necessarily regularly alternating.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Peptidomimetics
Sub Class
Depsipeptides
Direct Parent
Cyclic depsipeptides
Alternative Parents
Macrolide lactams / Alpha amino acid esters / Macrolides and analogues / Macrolactams / Tricarboxylic acids and derivatives / Tertiary carboxylic acid amides / Carboxylic acid esters / Lactones / Lactams / Oxacyclic compounds
show 6 more
Substituents
Aliphatic heteromonocyclic compound / Alpha-amino acid ester / Alpha-amino acid or derivatives / Azacycle / Carbonyl group / Carboxamide group / Carboxylic acid derivative / Carboxylic acid ester / Cyclic depsipeptide / Hydrocarbon derivative
show 15 more
Molecular Framework
Aliphatic heteromonocyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
65DD690W0C
CAS number
1393-87-9
InChI Key
MIZMDSVSLSIMSC-OGLSAIDSSA-N
InChI
InChI=1S/C33H57N3O9/c1-16(2)22-31(40)43-26(20(9)10)29(38)35(14)24(18(5)6)33(42)45-27(21(11)12)30(39)36(15)23(17(3)4)32(41)44-25(19(7)8)28(37)34(22)13/h16-27H,1-15H3/t22-,23-,24-,25?,26?,27?/m0/s1
IUPAC Name
(3S,9S,15S)-4,10,16-trimethyl-3,6,9,12,15,18-hexakis(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone
SMILES
[H]C1(OC(=O)[C@]([H])(C(C)C)N(C)C(=O)C([H])(OC(=O)[C@]([H])(C(C)C)N(C)C(=O)C([H])(OC(=O)[C@]([H])(C(C)C)N(C)C1=O)C(C)C)C(C)C)C(C)C

References

General References
Not Available
PubChem Compound
3084092
PubChem Substance
310264928
ChemSpider
2341206
RxNav
25437
Wikipedia
Fusafungine

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SolutionNasal
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0184 mg/mLALOGPS
logP3.81ALOGPS
logP4.96Chemaxon
logS-4.5ALOGPS
pKa (Strongest Acidic)18.8Chemaxon
pKa (Strongest Basic)-5.4Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count6Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area139.83 Å2Chemaxon
Rotatable Bond Count6Chemaxon
Refractivity166.6 m3·mol-1Chemaxon
Polarizability69.27 Å3Chemaxon
Number of Rings1Chemaxon
Bioavailability1Chemaxon
Rule of FiveNoChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSsplash10-0007-9000063000-4d74b57a4359e27ec8c5
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0006-0000009000-84268ed11e1979febc04
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0006-0000029000-5a6c81e507c63cc17587
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-000i-0000009000-8554784d8a1e15aec743
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-000j-0000079000-90d4f36442e9162cf53b
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-00dj-7000029000-3128ca2db87fac71915c
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0udi-0000090000-43f84626e0b05597bc7b
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-243.8532
predicted
DeepCCS 1.0 (2019)
[M+H]+245.74861
predicted
DeepCCS 1.0 (2019)
[M+Na]+251.40712
predicted
DeepCCS 1.0 (2019)

Drug created at June 09, 2014 15:07 / Updated at February 21, 2021 18:52