Fusafungine
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Identification
- Generic Name
- Fusafungine
- DrugBank Accession Number
- DB08965
- Background
Fusafungine is an antibiotic from Fusarium lateririum, and is used for the treatment of respiratory infections.
- Type
- Small Molecule
- Groups
- Approved, Withdrawn
- Structure
- Weight
- Average: 639.8204
Monoisotopic: 639.409480437 - Chemical Formula
- C33H57N3O9
- Synonyms
- Fusafungina
- Fusafungine
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcenocoumarol The risk or severity of bleeding can be increased when Fusafungine is combined with Acenocoumarol. Ambroxol The risk or severity of methemoglobinemia can be increased when Fusafungine is combined with Ambroxol. Articaine The risk or severity of methemoglobinemia can be increased when Fusafungine is combined with Articaine. BCG vaccine The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Fusafungine. Benzocaine The risk or severity of methemoglobinemia can be increased when Fusafungine is combined with Benzocaine. - Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
Categories
- ATC Codes
- R02AB03 — Fusafungine
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as cyclic depsipeptides. These are natural or synthetic compounds having sequences of amino and hydroxy carboxylic acid residues (usually α-amino and α-hydroxy acids) connected in a ring. The residues are commonly but not necessarily regularly alternating.
- Kingdom
- Organic compounds
- Super Class
- Organic acids and derivatives
- Class
- Peptidomimetics
- Sub Class
- Depsipeptides
- Direct Parent
- Cyclic depsipeptides
- Alternative Parents
- Macrolide lactams / Alpha amino acid esters / Macrolides and analogues / Macrolactams / Tricarboxylic acids and derivatives / Tertiary carboxylic acid amides / Carboxylic acid esters / Lactones / Lactams / Oxacyclic compounds show 6 more
- Substituents
- Aliphatic heteromonocyclic compound / Alpha-amino acid ester / Alpha-amino acid or derivatives / Azacycle / Carbonyl group / Carboxamide group / Carboxylic acid derivative / Carboxylic acid ester / Cyclic depsipeptide / Hydrocarbon derivative show 15 more
- Molecular Framework
- Aliphatic heteromonocyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 65DD690W0C
- CAS number
- 1393-87-9
- InChI Key
- MIZMDSVSLSIMSC-OGLSAIDSSA-N
- InChI
- InChI=1S/C33H57N3O9/c1-16(2)22-31(40)43-26(20(9)10)29(38)35(14)24(18(5)6)33(42)45-27(21(11)12)30(39)36(15)23(17(3)4)32(41)44-25(19(7)8)28(37)34(22)13/h16-27H,1-15H3/t22-,23-,24-,25?,26?,27?/m0/s1
- IUPAC Name
- (3S,9S,15S)-4,10,16-trimethyl-3,6,9,12,15,18-hexakis(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone
- SMILES
- [H]C1(OC(=O)[C@]([H])(C(C)C)N(C)C(=O)C([H])(OC(=O)[C@]([H])(C(C)C)N(C)C(=O)C([H])(OC(=O)[C@]([H])(C(C)C)N(C)C1=O)C(C)C)C(C)C)C(C)C
References
- General References
- Not Available
- External Links
- PubChem Compound
- 3084092
- PubChem Substance
- 310264928
- ChemSpider
- 2341206
- 25437
- Wikipedia
- Fusafungine
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Solution Nasal - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0184 mg/mL ALOGPS logP 3.81 ALOGPS logP 4.96 Chemaxon logS -4.5 ALOGPS pKa (Strongest Acidic) 18.8 Chemaxon pKa (Strongest Basic) -5.4 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 139.83 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 166.6 m3·mol-1 Chemaxon Polarizability 69.27 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 243.8532 predictedDeepCCS 1.0 (2019) [M+H]+ 245.74861 predictedDeepCCS 1.0 (2019) [M+Na]+ 251.40712 predictedDeepCCS 1.0 (2019)
Drug created at June 09, 2014 15:07 / Updated at February 21, 2021 18:52