You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.
Identification
NameBenzocaine
Accession NumberDB01086  (APRD00539)
TypeSmall Molecule
GroupsApproved
DescriptionA surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. [PubChem]
Structure
Thumb
Synonyms
4-aminobenzoic acid ethyl ester
Amben ethyl ester
Benzocaina
Benzocaine
Benzocainum
Ethyl Aminobenzoate
Ethyl p-Aminobenzoate
Ethyl p-Aminophenylcarboxylate
p-(Ethoxycarbonyl)aniline
p-Carbethoxyaniline
p-Ethoxycarboxylic Aniline
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Anal Swabs 20%stick20 %topicalEndovations Inc.1988-12-311997-07-15Canada
Endocaine Spray 20%spray20 %buccal; oralEndovations Inc.1988-12-311997-07-15Canada
Topical Anesthetic Bananagel, dentifrice220 mg/gdentalPatterson Dental1963-02-19Not applicableUs
Approved Generic Prescription ProductsNot Available
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
20/20 Topical Anestheticstrip10 mg/1dentalAdvanced Dental Anesthetics2012-02-28Not applicableUs
Allegenal-Mcream7.5 g/100gtopicalHalal Nutritional Center2015-01-28Not applicableUs
Alpha-caine Topical Anestheticgel200 mg/gtopicalDental Technologies, Inc.1999-12-312016-03-12Us
Alpha-caine Topical Anestheticgel200 mg/gtopicalDental Technologies, Inc.1999-12-312016-03-12Us
Alpha-caine Topical Anestheticgel200 mg/gtopicalDental Technologies, Inc.1999-12-312016-03-12Us
Alpha-caine Topical Anestheticgel200 mg/gtopicalDental Technologies, Inc.1999-12-312016-03-12Us
Americaineointment5.6 g/28gtopicalInsight Pharmaceuticals2009-07-10Not applicableUs
Americaineaerosol, spray11.4 g/57gtopicalInsight Pharmaceuticals2009-07-14Not applicableUs
Anbesol Baby Gel 7.5%gel7.5 %oralWyeth Consumer Healthcare Inc.1992-12-312006-07-24Canada
Anbesol Extra Strength Gel - 20%gel20 %topicalWhitehall Robins Inc.1995-12-312000-07-18Canada
Anbesol Jrgel100 mg/gtopicalPfizer Consumer Healthcare2005-05-11Not applicableUs
Anbesol Maximum Strengthgel200 mg/gtopicalPfizer Consumer Healthcare2005-05-11Not applicableUs
Anbesol Maximum Strengthsolution200 mg/mLtopicalPfizer Consumer Healthcare2005-05-11Not applicableUs
Anbesol Regular Strengthsolution100 mg/mLtopicalPfizer Consumer Healthcare2004-05-11Not applicableUs
Anbesol Regular Strengthgel100 mg/gtopicalPfizer Consumer Healthcare2005-05-11Not applicableUs
Anesgermgel.2 g/100goralCaribe Natural, Inc2015-04-30Not applicableUs
Anesgermgel.2 g/100goralWorld Perfumes, Inc2015-04-30Not applicableUs
Anestenkaliquid.2 mg/2mLtopicalMenper Distributors, Inc2014-01-01Not applicableUs
Anestheticgel200 mg/gtopicalMoore Medical LLC2012-07-12Not applicableUs
Assist II Anorectal (hemorrhoidal)liquid20 g/100mLtopicalTexas Electrolysis Supply2015-07-06Not applicableUs
Atopalm Oral Pain Reliefgel10 g/100goralNeo Pharm, Usa2012-02-06Not applicableUs
Baby Anbesolgel75 mg/gtopicalWyeth Consumer Healthcare2004-04-01Not applicableUs
Baby Anestenkaliquid2.1 mg/30mLtopicalMenper Distributors2014-01-01Not applicableUs
Baby Orajel Nighttime Formulagel7.5 %oralDel Pharmaceutics (Canada) Inc.1992-11-012005-06-24Canada
Baby Sensigelgel7.5 g/100gtopicalDr. Fresh, Inc2011-10-12Not applicableUs
Baby Sensigel Night Time Formulagel10 g/100gtopicalDr. Fresh, Inc2011-10-07Not applicableUs
Baby Teething Oral Pain Relievergel7.5 g/100gtopicalBudpak Inc.2010-05-01Not applicableUs
Bactimicina for Sore Throatlozenge15 mg/1oralDLC Laboratories, Inc.2011-05-24Not applicableUs
Bencocaine Topical Anestheticgel200 mg/gdentalBenco Dental2014-06-27Not applicableUs
Bencocaine Topical Anestheticgel200 mg/gdentalBenco Dental2014-06-27Not applicableUs
Bencocaine Topical Anestheticgel200 mg/gdentalBenco Dental2014-06-27Not applicableUs
Bencocaine Topical Anestheticgel200 mg/gdentalBenco Dental2014-06-27Not applicableUs
Bencocaine Topical Anestheticgel200 mg/gdentalBenco Dental2014-06-27Not applicableUs
Bencocaine Topical Anestheticgel200 mg/gdentalBenco Dental2014-06-27Not applicableUs
Bencocaine Topical Anestheticgel200 mg/gdentalBenco Dental2014-06-27Not applicableUs
Bencocaine Topical Anestheticgel200 mg/gdentalBenco Dental2014-06-27Not applicableUs
Bencocaine Topical Anestheticgel200 mg/gdentalBenco Dental2014-06-27Not applicableUs
Benz O Stheticgel20 g/100gtopicalGeritrex Corp.2012-01-26Not applicableUs
Benz O Stheticspray20 mL/100mLtopicalGeritrex Corp.2012-02-13Not applicableUs
Benzo Jelspray, metered11.4 g/57gdentalHenry Schein Inc.2016-02-01Not applicableUs
Benzocaineswab60 mg/mLtopicalUnifirst First Aid Corporation2014-08-26Not applicableUs
Benzocaineswab.12 mL/1topicalDynarex Corporation2011-01-24Not applicableUs
Benzocaineswab60 mg/mLtopicalDynarex Corporation2011-07-20Not applicableUs
Benzodentcream.2 g/gtopicalChattem, Inc.1994-05-12Not applicableUs
Bite and Sting Relief Well At Walgreensspray5 g/100gtopicalWalgreens2013-03-15Not applicableUs
Bite Relief Scherer Labscream5 g/100mLtopicalProduct Quest Mfg.2012-02-10Not applicableUs
Boil Easecream5 g/28gtopicalInsight Pharmaceuticals2010-06-21Not applicableUs
Boil Ease Pain Relieving Ointmentointment20 %topicalDel Pharmaceutics (Canada) Inc.1996-10-012005-06-20Canada
Boy Butter Desensitizing Lubricantcream73.9395789 mg/mLtopicalBoy Butter Lubes2012-09-25Not applicableUs
Boy Butter Desensitizing Lubricantcream71.9395789 mg/mLtopicalBoy Butter Lubes2012-09-25Not applicableUs
Boy Butter Extreme H2o Desensitizing Lubricantcream4.25 g/85.05gtopicalBoy Butter Lubes2011-05-20Not applicableUs
Brace Reliefgel9 mg/mLoralInfa Lab,Inc2005-01-03Not applicableUs
Budpak Baby Teething Oral Pain Relievergel7.5 g/100gtopicalBudpak Inc.2013-12-26Not applicableUs
Budpak Oral Maximum Strengthgel.2 g/gtopicalBudpak Inc.2013-06-10Not applicableUs
Burncare Cream 5.0%cream5 %topicalAvacare, Division Of Jeunique International Inc.1985-12-311997-11-10Canada
Caine Tips Oral Pain Relief Swabsswab20 %oralJ. Morita Usa, Inc.2005-05-052007-09-15Canada
Carmex Cold Sore Treatment External Analgesiccream10 g/100gtopicalCarma Laboratories, Inc.2014-05-28Not applicableUs
Cepacol Fizzlerstablet, orally disintegrating6 mg/1oralCombe Incorporated2009-09-01Not applicableUs
Cepacol Sensations Hydralozenge3 mg/1oralReckitt Benckiser LLC2012-05-28Not applicableUs
Cepacol Sensations Sore Throat Hydra Citrus Splashlozenge3 mg/1oralReckitt Benckiser LLC2013-07-15Not applicableUs
Cepacol Sensations Warminglozenge4 mg/1oralReckitt Benckiser LLC2012-06-102016-02-29Us
Certus Sting Relief Prep Padswab.06 mL/mLtopicalCertus Medical, Inc.2011-05-01Not applicableUs
Chloraseptic Warming Sore Throatlozenge15 mg/1oralPrestige Brands Holdings, Inc.2012-01-01Not applicableUs
Chloraseptic Warming Sore Throatlozenge15 mg/1oralPrestige Brands Holdings, Inc.2012-09-01Not applicableUs
Colgate Orabasepaste, dentifrice200 mg/gtopicalColgate Oral Pharmaceuticals, Inc.2010-08-31Not applicableUs
Comfortcaine Topical Anestheticgel200 mg/gdentalDental Technologies, Inc.1997-01-01Not applicableUs
Comfortcaine Topical Anestheticgel200 mg/gdentalDental Technologies, Inc.1997-01-01Not applicableUs
Comfortcaine Topical Anestheticgel200 mg/gdentalDental Technologies, Inc.1997-01-01Not applicableUs
Comfortcaine Topical Anestheticgel200 mg/gdentalDental Technologies, Inc.1997-01-01Not applicableUs
Comfortcaine Topical Anestheticgel200 mg/gdentalDental Technologies, Inc.1997-01-01Not applicableUs
Comfortcaine Topical Anestheticgel200 mg/gdentalDental Technologies, Inc.1997-01-01Not applicableUs
Cvs Fast Acting Baby Teethinggel75 mg/goralCVS Pharmacy2010-07-08Not applicableUs
Cvs Maximum Strengthpaste, dentifrice20 g/100gtopicalCVS Pharmacy2011-01-20Not applicableUs
Cvs Maximum Strength Boil Reliefointment20 g/100gtopicalCVS Pharmacy, Inc.2014-10-13Not applicableUs
Cvs Oral Anestheticliquid200 mg/mLoralCVS Pharmacy2010-07-08Not applicableUs
Cvs Pharmacy Instant Toothachegel, dentifrice20 g/100gdentalCVS Pharmacy2012-10-01Not applicableUs
Cvs Pharmacy Maximum Strengthgel, dentifrice20 g/100goralCVS Pharmacy2011-01-20Not applicableUs
Cvs Pharmacy Maximum Strengthgel, dentifrice20 g/100goralCVS Pharmacy2013-07-01Not applicableUs
Cvs Pharmacy Maximum Strengthliquid20 g/100gdentalCVS Pharmacy2015-01-01Not applicableUs
Cvs Pharmacy Nighttime Oral Pain Reliefgel, dentifrice10 g/100gdentalCVS Pharmacy2013-08-01Not applicableUs
Dental City Topical Anestheticgel200 mg/gdentalIcp Inc Dba Dental City2014-04-01Not applicableUs
Dental City Topical Anestheticgel200 mg/gdentalIcp Inc Dba Dental City2014-04-01Not applicableUs
Dental City Topical Anestheticgel200 mg/gdentalIcp Inc Dba Dental City2014-04-01Not applicableUs
Dental City Topical Anestheticgel200 mg/gdentalIcp Inc Dba Dental City2014-04-01Not applicableUs
Dental City Topical Anestheticgel200 mg/gdentalIcp Inc Dba Dental City2014-04-01Not applicableUs
Dental City Topical Anestheticgel200 mg/gdentalIcp Inc Dba Dental City2014-04-01Not applicableUs
Dental City Topical Anestheticgel200 mg/gdentalIcp Inc Dba Dental City2014-04-01Not applicableUs
Dental City Topical Anestheticgel200 mg/gdentalIcp Inc Dba Dental City2014-04-01Not applicableUs
Dental City Topical Anestheticgel200 mg/gdentalIcp Inc Dba Dental City2014-04-01Not applicableUs
Dental Reliefliquid200 mg/gtopicalCintas First Aid & Safety2012-06-13Not applicableUs
Dentek Instant Pain Relief Maximum Strengthliquid200 mg/mLtopicalDen Tek Oral Care. Inc.2014-02-01Not applicableUs
Dermawound Wound Care Venous Stasisointment1.27 g/100gtopicalWound Care USA, LLC2014-02-01Not applicableUs
Detane Gel 7.5%gel7.5 %topicalDel Pharmaceuticals Inc.1992-12-312004-07-20Canada
Dollar General Health Oral Pain Relievergel200 mg/gtopicalDolgencorp LLC2015-05-08Not applicableUs
Dollar General Toothache Reliefpaste, dentifrice20 g/100gtopicalDollar General2011-01-20Not applicableUs
Ejectdelay Gelgel7.5 g/100gtopicalInnovus Pharmaceuticals, Inc.2013-07-15Not applicableUs
Fidelis Topical Anestheticgel200 mg/gdentalWebco Dental & Medical Supplies, Inc.2014-01-01Not applicableUs
Fidelis Topical Anestheticgel200 mg/gdentalWebco Dental & Medical Supplies, Inc.2014-01-01Not applicableUs
Fidelis Topical Anestheticgel200 mg/gdentalWebco Dental & Medical Supplies, Inc.2014-01-01Not applicableUs
Fidelis Topical Anestheticgel200 mg/gdentalWebco Dental & Medical Supplies, Inc.2014-01-01Not applicableUs
Fidelis Topical Anestheticgel200 mg/gdentalWebco Dental & Medical Supplies, Inc.2014-01-01Not applicableUs
Fidelis Topical Anestheticgel200 mg/gdentalWebco Dental & Medical Supplies, Inc.2014-01-01Not applicableUs
Fidelis Topical Anestheticgel200 mg/gdentalWebco Dental & Medical Supplies, Inc.2014-01-01Not applicableUs
Fidelis Topical Anestheticgel200 mg/gdentalWebco Dental & Medical Supplies, Inc.2014-01-01Not applicableUs
Fidelis Topical Anestheticgel200 mg/gdentalWebco Dental & Medical Supplies, Inc.2014-01-01Not applicableUs
Finafta Babyliquid7.5 mg/100mgoralEfficient Laboratories Inc.2000-01-01Not applicableUs
Finafta Multioralspray7.5 mg/100mLoralEfficient Laboratories Inc.2004-09-01Not applicableUs
Gelato Topical Anestheticgel200 mg/gdentalMycone Dental Supply Co., Inc DBA Keystone Industries and Deepak Products Inc2013-07-01Not applicableUs
Gelato Topical Anestheticgel200 mg/gdentalMycone Dental Supply Co., Inc DBA Keystone Industries and Deepak Products Inc2013-07-01Not applicableUs
Gelato Topical Anestheticspray, metered11.4 g/57gdentalMycone Dental Supply Co., Inc DBA Keystone Industries and Deepak Products Inc2013-07-29Not applicableUs
Gelato Topical Anestheticgel200 mg/gdentalMycone Dental Supply Co., Inc DBA Keystone Industries and Deepak Products Inc2013-07-01Not applicableUs
Gelato Topical Anestheticgel200 mg/gdentalMycone Dental Supply Co., Inc DBA Keystone Industries and Deepak Products Inc2013-07-01Not applicableUs
Gelato Topical Anestheticgel200 mg/gdentalMycone Dental Supply Co., Inc DBA Keystone Industries and Deepak Products Inc2013-07-01Not applicableUs
Gelato Topical Anestheticgel200 mg/gdentalMycone Dental Supply Co., Inc DBA Keystone Industries and Deepak Products Inc2013-07-01Not applicableUs
Gelato Topical Anestheticgel200 mg/gdentalMycone Dental Supply Co., Inc DBA Keystone Industries and Deepak Products Inc2013-07-01Not applicableUs
Gelato Topical Anestheticgel200 mg/gdentalMycone Dental Supply Co., Inc DBA Keystone Industries and Deepak Products Inc2013-07-01Not applicableUs
Gelato Topical Anestheticgel200 mg/gdentalMycone Dental Supply Co., Inc DBA Keystone Industries and Deepak Products Inc2013-07-01Not applicableUs
Gelato Topical Anestheticgel200 mg/gdentalMycone Dental Supply Co., Inc DBA Keystone Industries and Deepak Products Inc2013-07-01Not applicableUs
Gingicaine Gel 20%gel20 %dentalGingi Pak Labs, Division Of Belport Co., Inc.1979-12-312004-08-16Canada
Gingicaine Liq Top Anestheticliquid20 %dentalGingi Pak Labs, Division Of Belport Co., Inc.1981-12-311997-08-11Canada
Good Neighbor Pain Reliefliquid200 mg/mLoralAmerisource Bergen Drug Corporation (Good Neighbor Pharmacy)2008-08-01Not applicableUs
Goodsense Oral Pain Reliefgel20 g/100gtopicalGeiss, Destin and Dunn, Inc.2014-05-09Not applicableUs
Goyescas 7 Syrups Sore Throat Reliefliquid50 mg/mLoralGoyescas Of Fla2015-10-01Not applicableUs
Goyescas Broncovac 5 Sore Throat Reliefliquid50 mg/mLoralGoyescas Of Fla2006-10-01Not applicableUs
Gps Topical Anestheticgel200 mg/gdentalGroup Practice Solutions, Inc.2013-07-01Not applicableUs
Gps Topical Anestheticgel200 mg/gdentalGroup Practice Solutions, Inc.2013-07-01Not applicableUs
Gps Topical Anestheticgel200 mg/gdentalGroup Practice Solutions, Inc.2013-07-01Not applicableUs
Gps Topical Anestheticgel200 mg/gdentalGroup Practice Solutions, Inc.2013-07-01Not applicableUs
Gps Topical Anestheticgel200 mg/gdentalGroup Practice Solutions, Inc.2013-07-01Not applicableUs
Gps Topical Anestheticgel200 mg/gdentalGroup Practice Solutions, Inc.2013-07-01Not applicableUs
Gumnumb Topical Anestheticgel200 mg/gdentalCrosstex International Inc.2013-07-01Not applicableUs
Gumnumb Topical Anestheticgel200 mg/gdentalCrosstex International Inc.2013-07-01Not applicableUs
Gumnumb Topical Anestheticgel200 mg/gdentalCrosstex International Inc.2013-07-01Not applicableUs
Gumnumb Topical Anestheticgel200 mg/gdentalCrosstex International Inc.2013-07-01Not applicableUs
Gumnumb Topical Anestheticgel200 mg/gdentalCrosstex International Inc.2013-07-01Not applicableUs
Gumnumb Topical Anestheticgel200 mg/gdentalCrosstex International Inc.2013-07-01Not applicableUs
Health-tec Topical Anestheticgel200 mg/gdentalDental Health Products, Inc.2015-04-01Not applicableUs
Health-tec Topical Anestheticgel200 mg/gdentalDental Health Products, Inc.2015-04-01Not applicableUs
Health-tec Topical Anestheticgel200 mg/gdentalDental Health Products, Inc.2015-04-01Not applicableUs
Health-tec Topical Anestheticgel200 mg/gdentalDental Health Products, Inc.2015-04-01Not applicableUs
Health-tec Topical Anestheticgel200 mg/gdentalDental Health Products, Inc.2015-04-01Not applicableUs
Health-tec Topical Anestheticgel200 mg/gdentalDental Health Products, Inc.2015-04-01Not applicableUs
Health-tec Topical Anestheticgel200 mg/gdentalDental Health Products, Inc.2015-04-01Not applicableUs
Heb Severe Toothachepaste, dentifrice20 g/100gtopicalHEB2011-01-20Not applicableUs
Herbasoul Male Genital Desensitizer Creamcream4.5 g/100gtopicalBodon Med Laboratories Ltd.2010-02-23Not applicableUs
Hurricainespray183 mg/gdental; periodontalBeutlich Pharmaceuticals LLC2010-06-15Not applicableUs
Hurricaine Dry Handle Swabliquid20 %topicalBeutlich L.P.2000-03-012006-06-14Canada
Hurricaine Topical Anestheticspray200 mg/gdental; oral; periodontalBeutlich Pharmaceuticals, LLC2014-09-01Not applicableUs
Hurricaine Topical Anestheticspray200 mg/gdental; oral; periodontalBeutlich Pharmaceuticals, LLC1979-06-15Not applicableUs
Hurricaine Topical Anestheticgel200 mg/gdental; periodontalBeutlich Pharmaceuticals LLC1998-09-15Not applicableUs
Hurricaine Topical Anestheticgel200 mg/gdental; oral; periodontalBeutlich Pharmaceuticals, LLC1971-08-15Not applicableUs
Hurricaine Topical Anesthetic Gelgel200 mg/gdental; oral; periodontalBeutlich Pharmaceuticals, LLC1986-08-15Not applicableUs
Hurricaine Topical Anesthetic Gelgel200 mg/gdental; oral; periodontalBeutlich Pharmaceuticals, LLC1993-02-15Not applicableUs
Hurricaine Topical Anesthetic Liquidliquid200 mg/gdental; oral; periodontalBeutlich Pharmaceuticals, LLC1986-08-15Not applicableUs
Hurricaine Topical Anesthetic Liquidliquid200 mg/gdental; oral; periodontalBeutlich Pharmaceuticals, LLC1969-05-15Not applicableUs
Hurricaine Topical Anesthetic Sprayaerosol21.9 %dental; topicalBeutlich L.P.1980-12-312005-10-13Canada
Insect Bite Reliefsolution150 mg/mLtopicalSwabplus Inc.2003-03-01Not applicableUs
Instant Toothache Pain Reliefliquid20 g/100goralCVS Pharmacy2009-10-01Not applicableUs
Intense Cvs Intense Toothachepaste, dentifrice20 g/100gtopicalCVS Pharmacy2011-01-20Not applicableUs
Iodent Maximum Strength Oral Analgesicgel20 g/100gtopicalUnited Exchange Corp2013-05-31Not applicableUs
Ismile Topical Anestheticgel200 mg/gdentalI Smile Dental Products, Inc.2014-06-01Not applicableUs
Ismile Topical Anestheticgel200 mg/gdentalI Smile Dental Products, Inc.2014-06-01Not applicableUs
Ismile Topical Anestheticgel200 mg/gdentalI Smile Dental Products, Inc.2014-06-01Not applicableUs
Ismile Topical Anestheticgel200 mg/gdentalI Smile Dental Products, Inc.2014-06-01Not applicableUs
Ismile Topical Anestheticgel200 mg/gdentalI Smile Dental Products, Inc.2014-06-01Not applicableUs
Ismile Topical Anestheticgel200 mg/gdentalI Smile Dental Products, Inc.2014-06-01Not applicableUs
Jianze Sting Relief Padsliquid6 g/100gtopicalChangzhou Jianze Sanitary Material Co., Ltd.2012-06-14Not applicableUs
Johnson and Johnson Burn Crm 5.0%cream5 %topicalJohnson & Johnson Inc1997-03-182000-07-11Canada
Kank-A Mouth Painliquid200 mg/mLbuccalBlistex Inc.2011-12-01Not applicableUs
Kmart Smart Sensepaste, dentifrice20 g/100gtopicalK Mart2013-12-01Not applicableUs
Kroger Toothache Pain Reliefpaste, dentifrice20 g/100gtopicalKroger2011-01-20Not applicableUs
Leader Oral Analgesicgel20 g/100goralCardinal Health2012-05-01Not applicableUs
Leader Oral Pain Relief Anestheticgel200 mg/goralCardinal Health2012-08-08Not applicableUs
Little Colds Sore Throat Relief Melt Awaysgranule6 mg/1oralMedtech Products Inc.2009-12-31Not applicableUs
Maintaingel7.5 %topicalDurex Canada, Division Of Ssl Canada Inc.1979-12-312007-07-24Canada
Major Oral Pain Relief Maximum Strengthliquid200 mg/mLoralMajor Pharmaceuticals2008-08-01Not applicableUs
Makesense Junior Pain Reliefgel7.5 g/100gtopicalCherry Hill Sales Co2014-07-15Not applicableUs
Makesense Pain Reliefgel20 g/100gtopicalCherry Hill Sales Co2014-07-15Not applicableUs
Male Desensitizer Pleasure Balmgel3 g/100mLtopicalKama Sutra2011-02-14Not applicableUs
Mandelay Male Genital Desensitizergel2.13 g/28.35gtopicalMajestic Drug Co., INC.1995-10-31Not applicableUs
Mark 3gel6.4 g/32gdental; oralCargus International, Inc.2014-02-28Not applicableUs
Mark 3gel6.4 g/32gdental; oralCargus International, Inc.2014-03-03Not applicableUs
Mark 3gel6.4 g/32gdental; oralCargus International, Inc.2014-02-28Not applicableUs
Mark 3gel6.4 g/32gdental; oralCargus International, Inc.2014-03-03Not applicableUs
Mark 3gel6.4 g/32gdental; oralCargus International, Inc.2014-03-03Not applicableUs
Mark 3gel6.4 g/32gdental; oralCargus International, Inc.2012-03-03Not applicableUs
Mark 3gel6.4 g/32gdental; oralCargus International, Inc.2014-02-28Not applicableUs
Mark 3gel6.4 g/32gdental; oralCargus International, Inc.2014-03-03Not applicableUs
Mark 3gel6.4 g/32gdental; oralCargus International, Inc.2014-03-03Not applicableUs
Mend19 Wound Care Venous Stasisointment1.27 g/100gtopicalWound Care USA, LLC2014-02-01Not applicableUs
Mouth Sore Medicationliquid200 mg/gtopicalZEE MEDICAL2010-05-01Not applicableUs
Mouth Sore Relief Applicatorliquid200 mg/mLoralSwabplus Inc.2005-06-01Not applicableUs
Mouth Sore Relief Professional Strengthliquid200 mg/goralCVS Pharmacy2009-10-01Not applicableUs
Ms Topical Anestheticgel200 mg/gdentalM&S Dental Supply Co., Llc2014-11-01Not applicableUs
Ms Topical Anestheticgel200 mg/gdentalM&S Dental Supply Co., Llc2014-11-01Not applicableUs
Ms Topical Anestheticgel200 mg/gdentalM&S Dental Supply Co., Llc2014-11-01Not applicableUs
Ms Topical Anestheticgel200 mg/gdentalM&S Dental Supply Co., Llc2014-11-01Not applicableUs
Ms Topical Anestheticgel200 mg/gdentalM&S Dental Supply Co., Llc2014-11-01Not applicableUs
Ms Topical Anestheticgel200 mg/gdentalM&S Dental Supply Co., Llc2014-11-01Not applicableUs
Ms Topical Anestheticgel200 mg/gdentalM&S Dental Supply Co., Llc2014-11-01Not applicableUs
My Fair Baby Instant Pain Reliefgel7.5 g/100gtopicalDelta Brands Inc2014-06-15Not applicableUs
Nene Denteliquid2.1 mg/30mLtopicalMenper Distributors, Inc2014-01-01Not applicableUs
Neuromed Facream200 mg/mLtopicalSambria Pharmaceuticals2015-12-22Not applicableUs
Neutracainepowder, for solution90 mg/1oralInvado Pharmaceuticals, Llc2014-03-07Not applicableUs
Nrg Topical Anestheticgel200 mg/gdentalIq Dental Supply, Llc2013-08-01Not applicableUs
Nrg Topical Anestheticgel200 mg/gdentalIq Dental Supply, Llc2013-08-01Not applicableUs
Nrg Topical Anestheticgel200 mg/gdentalIq Dental Supply, Llc2013-08-01Not applicableUs
Nrg Topical Anestheticgel200 mg/gdentalIq Dental Supply, Llc2013-08-01Not applicableUs
Nrg Topical Anestheticgel200 mg/gdentalIq Dental Supply, Llc2013-08-01Not applicableUs
Nrg Topical Anestheticgel200 mg/gdentalIq Dental Supply, Llc2013-08-01Not applicableUs
Nrg Topical Anestheticgel200 mg/gdentalIq Dental Supply, Llc2013-08-01Not applicableUs
Nrg Topical Anestheticgel200 mg/gdentalIq Dental Supply, Llc2013-08-01Not applicableUs
Nrg Topical Anestheticgel200 mg/gdentalIq Dental Supply, Llc2013-08-01Not applicableUs
Opahlgel6.4 g/32gdental; oralDharma Research, Inc.2013-11-02Not applicableUs
Opahlgel6.4 g/32gdental; oralDharma Research, Inc.2013-11-02Not applicableUs
Opahlgel6.4 g/32gdental; oralDharma Research, Inc.2013-11-02Not applicableUs
Opahlgel6.4 g/32gdental; oralDharma Research, Inc.2013-11-02Not applicableUs
Opahlgel6.4 g/32gdental; oralDharma Research, Inc.2013-11-02Not applicableUs
Opahlgel6.4 g/32gdental; oralDharma Research, Inc.2013-11-02Not applicableUs
Opahlgel6.4 g/32gdental; oralDharma Research, Inc.2013-11-02Not applicableUs
Opahlgel6.4 g/32gdental; oralDharma Research, Inc.2013-11-02Not applicableUs
Opahl Dye Freegel6.4 g/32gdental; oralDharma Research, Inc.2013-11-02Not applicableUs
Oragel Liq 205mg/gmliquid205 mgdentalCommerce Pharmaceutics Inc.1988-12-311999-08-05Canada
Orajel Denturegel20 %topicalDel Pharmaceutics (Canada) Inc.2000-08-082008-12-16Canada
Orajel Extra Strengthgel200 mgdentalCommerce Pharmaceutics Inc.1981-12-312000-07-27Canada
Orajel for All Mouth Sores Maximum Strengthswab.2 mL/mLtopicalChurch & Dwight Co., Inc.2010-08-01Not applicableUs
Orajel for Toothache Maximum Strengthswab.2 mL/mLtopicalChurch & Dwight Co., Inc.2010-08-11Not applicableUs
Orajel Instant Pain Relief for Toothache Maximum Strengthgel200 mg/gtopicalChurch & Dwight Co., Inc.2010-04-012016-02-18Us
Orajel Instant Pain Relief Maximumliquid200 mg/gtopicalChurch Dwight Co., Inc.2013-12-01Not applicableUs
Orajel Instant Pain Relief Maximumliquid200 mg/gtopicalChurch & Dwight Co., Inc.2013-12-01Not applicableUs
Orajel Instant Pain Relief Regulargel100 mg/gtopicalChurch Dwight Co., Inc.2013-12-01Not applicableUs
Orajel Instant Pain Relief Regular Strengthgel100 mg/gtopicalChurch & Dwight Co., Inc.2010-06-10Not applicableUs
Orajel Instant Pain Relief Severeliquid200 mg/gtopicalChurch & Dwight Co., Inc.2013-12-01Not applicableUs
Orajel Instant Relief for Teething Painswab.075 mL/mLtopicalChurch & Dwight Co., Inc.2010-08-01Not applicableUs
Orajel Instant Relief for Teething Pain Cooling Cucumbergel75 mg/gtopicalChurch & Dwight Co., Inc.2010-06-15Not applicableUs
Orajel Instant Relief for Teething Pain Daytime Nighttime Twin PackkitChurch & Dwight Co., Inc.2011-03-22Not applicableUs
Orajel Instant Relief for Teething Pain Longer Lastinggel75 mg/gtopicalChurch & Dwight Co., Inc.2011-03-22Not applicableUs
Orajel Maximum Strengthliquid.2 mL/mLtopicalChurch & Dwight Co., Inc.2010-04-01Not applicableUs
Orajel Nighttime Instant Relief for Teething Pain Longer Lasting Extra Strengthgel100 mg/gtopicalChurch & Dwight Co., Inc.2010-06-18Not applicableUs
Orajel Regular Strengthgel7.5 %oralDel Pharmaceutics (Canada) Inc.1992-12-312006-07-06Canada
Orajel Severe Toothache Maximum Strength Fast-acting Formulaliquid.2 mL/mLtopicalChurch & Dwight Co., Inc.2011-03-21Not applicableUs
Oral Analgesic Maximum Strengthgel200 mg/gtopicalMeijer Distribution, Inc.2010-05-13Not applicableUs
Oral Analgesic Maximum Strengthgel200 mg/gtopicalLif Elabs, A Division Of Atico International Usa, Inc.2010-11-01Not applicableUs
Oral Analgesic Maximum Strengthliquid.2 mL/mLtopicalMeijer Distribution Inc.2010-05-13Not applicableUs
Oral B Instant Pain Reliefgel.2 mL/mLoralHealth Tech, Inc.Not applicableNot applicableUs
Oral Gel Maximum Strengthgel20 g/100gtopicalBudpak Inc.2010-02-01Not applicableUs
Oral Pain Reliefgel200 mg/gtopicalKareway Product, Inc.2011-07-17Not applicableUs
Oral Pain Reliefgel200 mg/gtopicalDiscount Drug Mart, Inc.2015-11-09Not applicableUs
Oral Pain Relief Anesthetic Anestheticgel200 mg/goralMajor Pharmaceuticals2009-08-19Not applicableUs
Oral Pain Relieverliquid20 g/100goralDolgencorp LLC2012-01-10Not applicableUs
Oralabs Cold Sore Treatmentointment5 mg/gtopicalOra Labs2014-08-01Not applicableUs
Outgroliquid.009 mg/mLtopicalMedtech Products Inc.2013-01-01Not applicableUs
Pac-dent Top Gelgel200 mg/gdentalPac Dent International, Inc.2013-07-01Not applicableUs
Pac-dent Top Gelgel200 mg/gdentalPac Dent International, Inc.2013-07-01Not applicableUs
Pac-dent Top Gelgel200 mg/gdentalPac Dent International, Inc.2013-07-01Not applicableUs
Pac-dent Top Gelgel200 mg/gdentalPac Dent International, Inc.2013-07-01Not applicableUs
Pac-dent Top Gelgel200 mg/gdentalPac Dent International, Inc.2013-07-01Not applicableUs
Pain Reliefliquid200 mg/gtopicalSafetec of America, Inc.2010-05-01Not applicableUs
Patterson Dental Topical Anestheticgel200 mg/gdentalPatterson Dental2015-02-01Not applicableUs
Patterson Dental Topical Anestheticgel200 mg/gdentalPatterson Dental2015-02-01Not applicableUs
Patterson Dental Topical Anestheticgel200 mg/gdentalPatterson Dental2015-02-01Not applicableUs
Patterson Dental Topical Anestheticgel200 mg/gdentalPatterson Dental2015-02-01Not applicableUs
Patterson Dental Topical Anestheticgel200 mg/gdentalPatterson Dental2015-02-01Not applicableUs
Patterson Dental Topical Anestheticgel200 mg/gdentalPatterson Dental2015-02-01Not applicableUs
Patterson Dental Topical Anestheticgel200 mg/gdentalPatterson Dental2015-02-01Not applicableUs
Patterson Dental Topical Anestheticgel200 mg/gdentalPatterson Dental2015-02-01Not applicableUs
Patterson Dental Topical Anestheticgel200 mg/gdentalPatterson Dental2015-02-01Not applicableUs
Pleasure Balm Kama Sutragel5 g/100mLtopicalKama Sutra2013-09-12Not applicableUs
Preboostliquid4 g/100mLtopical944 Corp2014-02-18Not applicableUs
Preboostliquid4 g/100mLtopicalAspen Park Pharmaceuticals, Inc2015-03-30Not applicableUs
Primo Topical Anestheticgel200 mg/gdentalTri State Dental2014-03-01Not applicableUs
Primo Topical Anestheticgel200 mg/gdentalTri State Dental2014-03-01Not applicableUs
Primo Topical Anestheticgel200 mg/gdentalTri State Dental2014-03-01Not applicableUs
Primo Topical Anestheticgel200 mg/gdentalTri State Dental2014-03-01Not applicableUs
Primo Topical Anestheticgel200 mg/gdentalTri State Dental2014-03-01Not applicableUs
Primo Topical Anestheticgel200 mg/gdentalTri State Dental2014-03-01Not applicableUs
Primo Topical Anestheticgel200 mg/gdentalTri State Dental2014-03-01Not applicableUs
Primo Topical Anestheticgel200 mg/gdentalTri State Dental2014-03-01Not applicableUs
Primo Topical Anestheticgel200 mg/gdentalTri State Dental2014-03-01Not applicableUs
Pro-caine Topical Anesthetic Gelgel20 %dental; topicalPdt Image Inc. Dba Pro Dentec Canada2002-12-122009-06-15Canada
Projel-20gel20 1/100gtopicalSeptodont, Inc.1989-12-15Not applicableUs
Projel-20gel20 g/100gtopicalSeptodont, Inc.1989-12-15Not applicableUs
Projel-20gel20 g/100gtopicalSeptodont, Inc.1989-12-15Not applicableUs
Projel-20gel20 g/100gtopicalSeptodont, Inc.1989-12-15Not applicableUs
Purelife Topical Anestheticgel200 mg/gdentalPure Life Dental2013-07-01Not applicableUs
Purelife Topical Anestheticgel200 mg/gdentalPure Life Dental2013-07-01Not applicableUs
Purelife Topical Anestheticgel200 mg/gdentalPure Life Dental2013-07-01Not applicableUs
Purelife Topical Anestheticgel200 mg/gdentalPure Life Dental2013-07-01Not applicableUs
Purelife Topical Anestheticgel200 mg/gdentalPure Life Dental2013-07-01Not applicableUs
Purelife Topical Anestheticgel200 mg/gdentalPure Life Dental2013-07-01Not applicableUs
Purelife Topical Anestheticgel200 mg/gdentalPure Life Dental2013-07-01Not applicableUs
Purelife Topical Anestheticgel200 mg/gdentalPure Life Dental2013-07-01Not applicableUs
Quality Choice Maximum Strength Oral Pain Relievinggel20 g/100gtopicalChain Drug Marketing Association Inc2013-05-31Not applicableUs
Red Cross Oral Pain Reliefliquid200 mg/mLtopicalThe Mentholatum Company2013-06-01Not applicableUs
Rexall Maximum Strengthliquid20 g/100gdentalRexall2015-01-01Not applicableUs
Rite Aid Baby Caregel, dentifrice7.5 g/100goralRite Aid2011-01-20Not applicableUs
Rite Aid Liquid Anesthetic Oral Pain Reliefgel200 mg/mLoralRite Aid Corporation2010-07-08Not applicableUs
Rite Aid Maximum Strengthgel, dentifrice20 g/100goralRite Aid2011-01-20Not applicableUs
Rite Aid Maximum Strengthliquid20 g/100gdentalRite Aid2015-01-01Not applicableUs
Rite Aid Maximum Strengthpaste, dentifrice20 g/100gtopicalRite Aid2011-01-20Not applicableUs
Rite Aid Oral Pain Relieverliquid20 g/100goralRite Aid2013-08-01Not applicableUs
Rite Aid Professional Strengthliquid20 g/100goralRite Aid2014-01-01Not applicableUs
Rougier Swab Insect Bite Relief Swabsswab15 %topicalRougier Pharma Division Of Ratiopharm Inc2004-04-282008-08-04Canada
Sally Hansen Microwavable Eybrow, Face and Lip Wax KitkittopicalCoty US LLC2012-01-01Not applicableUs
Sally Hansen Ouch-relief Numbing Wipescloth.0543 g/1topicalCoty US LLC2015-01-01Not applicableUs
Sally Hansen Ouch-relief Wax KitkittopicalCoty US LLC2012-01-01Not applicableUs
Sally Hansen Ouch-relief Wax Strip KitkittopicalCoty US LLC2012-01-01Not applicableUs
Sensigelgel20 g/100gtopicalDr. Fresh, Inc.2011-09-26Not applicableUs
Severe Oral Pain Relieverliquid20 g/100goralCVS Pharmacy2011-12-27Not applicableUs
Severe Oral Pain Relieverliquid20 g/100goralWalgreens2012-01-10Not applicableUs
Sheffield Baby Teething Gelgel75 mg/goralFaria LLC dba Sheffield Pharmaceuticals2003-06-17Not applicableUs
Sheffield Pain Reliefgel200 mg/goralFaria LLC dba Sheffield Pharmaceuticals2006-01-30Not applicableUs
Shunga Male Genital Desensitizeraerosol, spray1.125 g/15gtopicalEau Zone Oils & Fragrances LTD2010-08-01Not applicableUs
Shunga Sensation Balmgel5.06 g/67.5gtopicalEau Zone Oils And Fragrances Ltd2000-01-01Not applicableUs
Shunga Sensation Balmgel5.07 g/67.5gtopicalEau Zone Oils And Fragrances Ltd2000-01-01Not applicableUs
Shunga Sensation Balmgel5.07 g/67.5gtopicalEau Zone Oils And Fragrances Ltd2005-01-01Not applicableUs
Shunga Sensation Balmgel5.07 g/67.5gtopicalEau Zone Oils And Fragrances Ltd2000-01-01Not applicableUs
Sirop Dentitionsyrup1.8 %dentalSabex Inc1951-12-312001-08-02Canada
Sting and Biteswab6 g/100mLtopicalPHOENIX HEALTHCARE SOLUTIONS, LLC2015-02-23Not applicableUs
Sting Relief Medicated Padswab.06 mg/1topicalTongzhou Ruihong Medical Products Factory2013-05-20Not applicableUs
Sting Relief Padsswab.06 mL/mLtopicalJiangsu Province Jian Er Kang Medical Dressing Co. ,Ltd.2010-01-01Not applicableUs
Swabplus Anesthetic Swabsswab20 %topicalSwabplus Canada Inc.2003-06-152008-09-22Canada
Swabplus Tooth & Gum Pain Relief Swabsswab20 %oralSwabplus Canada Inc.2004-05-052008-09-22Canada
Tanacliquid1.3 mg/13mLoralInsight Pharmaceuticals LLC2011-01-01Not applicableUs
Terrasil Boil Pain Reliefointment3.5 g/100gtopicalAidance Skincare & Topical Solutions, LLC2014-06-20Not applicableUs
Tiger Supply Inc Topical Anestheticgel200 mg/gdentalTiger Supply Inc.2013-05-08Not applicableUs
Tiger Supply Inc Topical Anestheticgel200 mg/gdentalTiger Supply Inc.2013-05-08Not applicableUs
Tiger Supply Inc Topical Anestheticgel200 mg/gdentalTiger Supply Inc.2013-05-08Not applicableUs
Tiger Supply Inc Topical Anestheticgel200 mg/gdentalTiger Supply Inc.2013-05-08Not applicableUs
Tiger Supply Inc Topical Anestheticgel200 mg/gdentalTiger Supply Inc.2013-05-08Not applicableUs
Tiger Supply Inc Topical Anestheticgel200 mg/gdentalTiger Supply Inc.2013-05-08Not applicableUs
Tokisan Sore Throat Reliefliquid50 mg/mLoralGoyescas Of Fla1958-08-01Not applicableUs
Top Quality Mfg. Topical Anestheticgel200 mg/gdentalTop Quality Manufacturing, Inc.2014-05-01Not applicableUs
Top Quality Mfg. Topical Anestheticgel200 mg/gdentalTop Quality Manufacturing, Inc.2014-05-01Not applicableUs
Top Quality Mfg. Topical Anestheticgel200 mg/gdentalTop Quality Manufacturing, Inc.2014-05-01Not applicableUs
Top Quality Mfg. Topical Anestheticgel200 mg/gdentalTop Quality Manufacturing, Inc.2014-05-01Not applicableUs
Top Quality Mfg. Topical Anestheticgel200 mg/gdentalTop Quality Manufacturing, Inc.2014-05-01Not applicableUs
Top Quality Mfg. Topical Anestheticgel200 mg/gdentalTop Quality Manufacturing, Inc.2014-05-01Not applicableUs
Top Quality Mfg. Topical Anestheticgel200 mg/gdentalTop Quality Manufacturing, Inc.2014-05-01Not applicableUs
Topcare Maximum Strengthliquid20 g/100goralTopco2014-10-01Not applicableUs
Topicaine - Top Gel 20%gel20 %oral; topicalHoechst Marion Roussel Canada Inc.1996-12-182000-07-28Canada
Topicaine Gel 20%gel200 mgoral; topicalHoechst Roussel Canada Inc.1993-12-311999-08-11Canada
Topical Anesthetic Bananagel200 mg/gdentalSafco Dental Supply Co.2012-08-06Not applicableUs
Topical Anesthetic Bubble Gumgel200 mg/gdentalSafco Dental Supply Co.2012-08-06Not applicableUs
Topical Anesthetic Bubble Gumgel220 mg/gdentalPatterson Dental Supply Inc1963-02-19Not applicableUs
Topical Anesthetic Cherrygel220 mg/gdentalPatterson Dental Supply Inc1963-02-19Not applicableUs
Topical Anesthetic Cherrygel200 mg/gdentalSafco Dental Supply Co.2012-08-06Not applicableUs
Topical Anesthetic Mintgel220 mg/gdentalPatterson Dental Supply Inc1963-02-19Not applicableUs
Topical Anesthetic Mintgel200 mg/gdentalSafco Dental Supply Co.2012-08-06Not applicableUs
Topical Anesthetic Pina Coladagel200 mg/gdentalSafco Dental Supply Co.2012-08-06Not applicableUs
Topical Anesthetic Pina Coladagel220 mg/gdentalPatterson Dental Supply Inc1963-02-19Not applicableUs
Topical Anesthetic Raspberrygel200 mg/gdentalSafco Dental Supply Co.2012-08-06Not applicableUs
Topical Anesthetic Raspberrygel220 mg/gdentalPatterson Dental Supply Inc1963-02-19Not applicableUs
Topical Anesthetic Strawberrygel220 mg/gdentalPatterson Dental Supply Inc1963-02-19Not applicableUs
Topical Anesthetic Strawberrygel200 mg/gdentalSafco Dental Supply Co.2012-08-06Not applicableUs
Ultracare Anesthetic Bubble Gumgel6.96 g/30mLdentalUltradent Products, Inc.1986-06-01Not applicableUs
Ultracare Anesthetic Butter Rumgel6.96 g/30mLdentalUltradent Products, Inc.1986-06-01Not applicableUs
Ultracare Anesthetic Creme De Menthegel6.96 g/30mLdentalUltradent Products, Inc.1986-06-01Not applicableUs
Ultracare Anesthetic Pina Coladagel6.96 g/30mLdentalUltradent Products, Inc.1986-06-01Not applicableUs
Ultracare Anesthetic Walterberrygel6.96 g/30mLdentalUltradent Products, Inc.1993-06-01Not applicableUs
Walgreens Baby Teethinggel, dentifrice7.5 g/100goralWalgreens2011-01-20Not applicableUs
Walgreens Baby Teethinggel, dentifrice7.5 g/100goralWalgreens2013-09-01Not applicableUs
Walgreens Cold Sore Treatmentointment5 mg/gtopicalWalgreens2015-04-01Not applicableUs
Walgreens Intense Toothachepaste, dentifrice20 g/100gtopicalWalgreens2011-01-20Not applicableUs
Walgreens Maximum Strengthpaste, dentifrice20 g/100gtopicalWalgreens2013-08-01Not applicableUs
Walgreens Maximum Strengthpaste, dentifrice20 g/100gtopicalWalgreens2011-01-20Not applicableUs
Walgreens Pain Relieving for Boilsointment20 g/100gtopicalWalgreen Company2014-05-28Not applicableUs
Walgreens Severe Oral Pain Relieverliquid20 g/100goralWalgreens2012-01-10Not applicableUs
Walgreens Severe Toothache Reliefpaste, dentifrice20 g/100gtopicalWalgreens2013-08-01Not applicableUs
Winco Foods Maximum Strength Oral Analgesicgel200 mg/gtopicalWin Co Foods, Llc2014-12-01Not applicableUs
Zilactin Baby (teething Gel)gel10 %topicalZila Pharmaceuticals Inc.1998-11-022008-02-08Canada
Zilactin Tooth and Gum Pain Relieverswab20 %oralBlairex Laboratories, Inc.2005-11-082008-07-23Canada
Zilactin Toothache Swabswab20 %topicalZila Pharmaceuticals Inc.2002-01-042008-02-11Canada
Zilactin-Bgel.1 g/gtopicalBlairex Laboratories, Inc.2005-06-29Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Beegentle Topical Anestheticgel210 mg/gtopicalCao Group, Inc.2010-09-01Not applicableUs
Benzo-jelgel200 mg/gtopicalHenry Schein, Inc.2015-07-03Not applicableUs
Benzo-jelgel200 mg/gtopicalHenry Schein, Inc.2015-07-03Not applicableUs
Benzo-jelgel200 mg/gtopicalHenry Schein, Inc.2015-07-03Not applicableUs
Benzo-jel Bubble Gumgel230 mg/mLdentalHenry Schein Inc1963-02-19Not applicableUs
Benzo-jel Cherrygel230 mg/mLdentalHenry Schein Inc1963-02-19Not applicableUs
Benzo-jel Mintgel230 mg/mLdentalHenry Schein Inc1963-02-19Not applicableUs
Benzo-jel Pina Coladagel230 mg/mLdentalHenry Schein Inc1963-02-19Not applicableUs
Benzo-jel Raspberrygel, dentifrice220 mg/gdentalHenry Schein, Inc.1963-02-19Not applicableUs
Benzo-jel Strawberrygel230 mg/mLdentalHenry Schein Inc1963-02-19Not applicableUs
Benzocaine Bubble Gumgel, dentifrice220 mg/gdentalDarby Dental Supply, LLC1963-02-19Not applicableUs
Benzocaine Cherrygel, dentifrice220 mg/gdentalDarby Dental Supply, LLC1963-02-19Not applicableUs
Benzocaine Mintgel, dentifrice220 mg/gdentalDarby Dental Supply, LLC1963-02-19Not applicableUs
Benzocaine Pina Coladagel, dentifrice220 mg/gdentalDarby Dental Supply, LLC1963-02-19Not applicableUs
Benzocaine Raspberrygel, dentifrice220 mg/gdentalDarby Dental Supply, LLC1963-02-19Not applicableUs
Benzocaine Strawberrygel, dentifrice220 mg/gdentalDarby Dental Supply, LLC1963-02-19Not applicableUs
Denti-care Denti-freeze Topical Anesthetic Bubblegumointment.2 g/mLdentalAr Medicom Inc2005-07-28Not applicableUs
Denti-care Denti-freeze Topical Anesthetic Cherryointment.2 g/mLdentalAr Medicom Inc2005-07-28Not applicableUs
Denti-care Denti-freeze Topical Anesthetic Mintointment.2 g/mLdentalAr Medicom Inc2005-07-28Not applicableUs
Denti-care Denti-freeze Topical Anesthetic Raspberryointment.2 g/mLdentalAr Medicom Inc2005-07-28Not applicableUs
Denti-care Denti-freeze Topical Anesthetic Strawberryointment.2 g/mLdentalAr Medicom Inc2005-07-28Not applicableUs
Gelato Topical Anestheticgel6 g/30gdentalMycone Dental Supply Co., Inc Dba Keystone Industries And Deepak Products Inc.2012-12-122016-03-31Us
Gelato Topical Anestheticgel6 g/30gdentalMycone Dental Supply Co., Inc Dba Keystone Industries And Deepak Products Inc.2012-12-12Not applicableUs
Gelato Topical Anestheticgel6 g/30gdentalMycone Dental Supply Co., Inc Dba Keystone Industries And Deepak Products Inc.2012-12-122016-02-28Us
Gelato Topical Anestheticgel6 g/30gdentalMycone Dental Supply Co., Inc Dba Keystone Industries And Deepak Products Inc.2012-12-12Not applicableUs
Gelato Topical Anestheticgel6 g/30gdentalMycone Dental Supply Co., Inc Dba Keystone Industries And Deepak Products Inc.2012-12-12Not applicableUs
Gelato Topical Anestheticgel6 g/30gdentalMycone Dental Supply Co., Inc Dba Keystone Industries And Deepak Products Inc.2012-12-12Not applicableUs
Lollicaine Bubble Gumgel, dentifrice220 mg/gdentalCentrix, Inc.1963-02-19Not applicableUs
Lollicaine Cherrygel, dentifrice220 mg/gdentalCentrix, Inc.1963-02-19Not applicableUs
Lollicaine Mintgel, dentifrice220 mg/gdentalCentrix, Inc.1963-02-19Not applicableUs
Lollicaine Pina Coladagel, dentifrice220 mg/gdentalCentrix, Inc.1963-02-19Not applicableUs
Medicaine Sting and Biteswab.12 g/.6mLtopicalDynarex Corporation1976-02-14Not applicableUs
Medicaine Sting and Biteswab.12 g/gtopicalCustom Kits Company Inc2015-10-14Not applicableUs
Opahlspray, metered12 g/60gdental; oral; topicalDharma Research, Inc.2013-01-01Not applicableUs
Orabase Benzocaine Purple Icepaste, dentifrice19.8 mg/gdentalColgate Oral Pharmaceuticals, Inc.2012-08-01Not applicableUs
Pennacainesolution/ drops200 mg/mLauricular (otic)Larken Laboratories, Inc.2011-08-082015-12-29Us
Precaine Bgel221 mg/gdentalPascal Company, Inc.2009-04-27Not applicableUs
Topex Bananagel, dentifrice220 mg/gdentalDs Healthcare1963-02-19Not applicableUs
Topex Bubble Gumgel, dentifrice220 mg/gdentalDs Healthcare1963-02-19Not applicableUs
Topex Bubble Gumgel, dentifrice220 mg/gdentalDentsply Caulk1963-02-19Not applicableUs
Topex Bubble Gumgel, dentifrice220 mg/gdentalDs Healthcare1963-02-19Not applicableUs
Topex Cherrygel, dentifrice220 mg/gdentalDs Healthcare1963-02-19Not applicableUs
Topex Cherrygel, dentifrice220 mg/gdentalDs Healthcare1963-02-19Not applicableUs
Topex Cherrygel, dentifrice220 mg/gdentalDentsply Caulk1963-02-19Not applicableUs
Topex Mintgel, dentifrice220 mg/gdentalDentsply Caulk1963-02-19Not applicableUs
Topex Mintgel, dentifrice220 mg/gdentalDs Healthcare1963-02-19Not applicableUs
Topex Mintgel, dentifrice220 mg/gdentalDs Healthcare1963-02-19Not applicableUs
Topex Pina Coladagel, dentifrice220 mg/gdentalDs Healthcare1963-02-19Not applicableUs
Topex Pina Coladagel, dentifrice220 mg/gdentalDentsply Caulk1963-02-19Not applicableUs
Topex Pina Coladagel, dentifrice220 mg/gdentalDs Healthcare1963-02-19Not applicableUs
Topex Raspberrygel, dentifrice220 mg/gdentalDs Healthcare1963-02-19Not applicableUs
Topex Strawberrygel, dentifrice220 mg/gdentalDs Healthcare1963-02-19Not applicableUs
International Brands
NameCompany
AnacaineNot Available
AnaesthesinNot Available
Anbesol BabyNot Available
DermoplastNot Available
Brand mixtures
NameLabellerIngredients
10 Person AnsiGenuine First Aid LLC
25 Person AnsiGenuine First Aid LLC
3m Nexcare Cold Sore Treatment3 M Company
50 Person AnsiGenuine First Aid LLC
Acella Antipyrine and Benzocaine OticACELLA PHARMACEUTICALS
Acme First Aid Contains 404 PiecesAcme United Corp.
ActisepActipharma, Inc
AdazinSterling Knight Pharmaceuticals, Llc
Aeroaid Antiseptic First AidAero Healthcare, Llc.
Aeroburn Burn First AidAero Healthcare, Llc.
Aidplus Sting Relief Prep PadPlanet (Suzhou) Medical Products Co. Ltd
Alcohol Prep Pad With BenzocaineMajor Pharmaceuticals
Alcohol Prep PadsTarget Corporation
Alcohol Prep Pads With Pain ReliefMc Kesson
Alcohol Prep Swab With Pain ReliefH and P Industries, Inc. dba Triad Group
Alcohol Swab With BenzocaineCardinal Health
Alcohol Swabs With BenzocaineRite Aid Corporation
Anbesol Cold Sore TherapyPfizer Consumer Healthcare
Anbesol GelWyeth Consumer Healthcare Inc.
Anbesol LiquidWyeth Consumer Healthcare Inc.
Anbesol Maximum Strength LiquidWyeth Consumer Healthcare Inc.
Angidol Cherry FlavorGrandall Distributing Co., Inc.
Angidol Honey Lemon FlavorGrandall Distributing Co., Inc.
AnivyAllen & Hanburys A Glaxo Canada Ltd. Co.
Anti ItchWalgreen Company
Antipyrine and BenzocaineRebel Distributors Corp
Antipyrine and Benzocaine OticACELLA PHARMACEUTICALS
AntisepticAfassco Inc.
Antiseptic First AidAcme United Corp
AppedrineChattem Canada
Arc First Aid Contains 1000 PiecesAmerican Red Cross
Arc First Aid Contains 404 PiecesAmerican Red Cross
ArkodyneLaboratoire Romilo
Assured Feminine Anti-itchGREENBRIER INTERNATIONAL
AuralganPaladin Labs Inc
Auralgan EardropsWyeth Canada
Auralgan SolutionWyeth Consumer Healthcare Inc.
Aurax OticAcella Pharmaceuticals, LLC
Aurisan DpsLab Nadeau LtÉe, Division Of Technilab Inc.
AurodexMajor Pharmaceuticals
Auto 157Genuine First Aid LLC
Balminil LozRougier Pharma Division Of Ratiopharm Inc
Balzarol OntRolmex International Inc.
Benzal Vagisil Creme Regular StrengthCombe Incorporated
Benzocaine and ResorcinolRite Aid
Benzocaine and TriclosanPremier Brands of America Inc.
Best Health Sore Throat Relief Cherry FlavorBestco, Inc.
Bionet LozengeChurch & Dwight Canada Corp
Bite ReliefPic Corporation
Blistex Foille Medicated First AidBlistex Inc.
Budpack Feminine Anti-itchBudpak Inc.
Budpak Feminine Anti-itchBudpak Inc.
Burn O Sol SprayProtector Canada Inc.
Burncare KitAvacare, Division Of Jeunique International Inc.
Bye Bye Bite LotDavid D. Daniels Ltd.
Bye Bye Burn LotDavid D. Daniels Ltd.
Cepacol Citrus Extra Strength LozengesCombe Incorporated
Cepacol Dual ReliefCombe Incorporated
Cepacol Extra Strength LozengeCombe Incorporated
Cepacol Extra Strength Orange Citrus LozengeCombe Incorporated
Cepacol Extra Strength Sore Throat and CoughReckitt Benckiser LLC
Cepacol Extra Strength Sore Throat CherryReckitt Benckiser LLC
Cepacol Extra Strength Sore Throat Honey LemonReckitt Benckiser LLC
Cepacol Extra Strength Sore Throat Mixed BerryReckitt Benckiser LLC
Cepacol Extra Strength Sore Throat Sugar Free CherryReckitt Benckiser LLC
Cepacol Extra Strength Sore Throat TangerineReckitt Benckiser LLC
Cepacol Sensations CoolingReckitt Benckiser LLC
Cepacol Sensations Sore Throat Cooling Ice CoolReckitt Benckiser LLC
Cepacol Sore ThroatRebel Distributors Corp
Cepacol Sore Throat and CoughReckitt Benckiser LLC
Cepacol Sore Throat Extra Strength Sucrose-free Lozenge (cherry Flavour)Combe Incorporated
Cepacol Sore Throat Maximum Numbing CherryCombe Incorporated
Cepacol Sore Throat Maximum Numbing CitrusCombe Incorporated
Cepacol Sore Throat Maximum Numbing Honey LemonCombe Incorporated
Cepacol Sore Throat Maximum Numbing Sugar Free CherryCombe Incorporated
Cepacol Sore Throat Plus CoatingCombe Incorporated
Cepacol Sore Throat Plus CoughCombe Incorporated
Cepacol Ultra Sore ThroatReckitt Benckiser LLC
Cetacaine AnestheticCetylite Industries, Inc.
Cetacaine LiquidCetylite Industries Inc.
Cetacaine SprayCetylite Industries Inc.
Cetacaine Topical AnestheticCetylite Industries, Inc.
Cherry Sore Throat LozengesMeijer Distribution Inc.
Chloraseptic Sore Throat Liquid CenterPrestige Brands Holdings, Inc.
Chloraseptic Sore Throat Max Liquid CenterPrestige Brands Holdings, Inc.
Coghlan S Sting ReliefCoghlan's Ltd
Cold Sore LotionD.C. Labs Limited
Cut Care Insect Bite Antiseptic and Pain Relieving WipeZeus Medical Holdings LLC
Cut CleanerAfassco Inc
CutiecaineInnovatech Inc
Cvs Adult EnemaSummit Pharmaceuticals
Cvs Pharmacy Mouth Sore GelCVS Pharmacy
Cvs Sore Throat Mixed Berry FlavorCVS Pharmacy, Inc.
Dentalgar LiqProduits Marc O (1987) Inc., Division Of Technilab Inc.
Denti-care Denti-freeze Topical Anesthetic BubblegumAr Medicom Inc
Denti-care Denti-freeze Topical Anesthetic CherryAr Medicom Inc
Denti-care Denti-freeze Topical Anesthetic GelA.R. Medicom Inc.
Denti-care Denti-freeze Topical Anesthetic MintAr Medicom Inc
Denti-care Denti-freeze Topical Anesthetic RaspberryAr Medicom Inc
Denti-care Denti-freeze Topical Anesthetic StrawberryAr Medicom Inc
Denti-care Topical Anesthetic GelA.R. Medicom Inc.
Denti-care Topical Anesthetic Liquid SprayA.R. Medicom Inc.
Denture Orajel GelCommerce Pharmaceutics Inc.
Dermacaine-RInnovatech Inc
Dermaphy OntProduits Phyto Inc.
Dermoplast Pain RelievingMedtech Products Inc.
Dermoplast Pain Relieving AntibacterialMedtech Products Inc.
Dexatrim TabletsChattem Canada
Docusol PlusEnemeez Inc. Dba Summit Pharmaceuticals
Dukal Sting Relief PadDukal Corporation
Emercol LozPharmavite Laboratories (1987) Inc.
EndosprayAxcan Pharma Inc
Enemeez PlusEnemeez Inc. Dba Summit Pharmaceuticals
Equaline Vagicaine Maximum StrengthSupervalu Inc
Equate Vagicaine Maximum StrengthWal Mart Stores Inc
Extra Strength Cepacol Sore ThroatReckitt Benckiser (Canada) Inc
FinaftaEfficient Laboratories Inc.
First AidHART Health
First Aid AntisepticUniShield
First Aid Antiseptic Well At WalgreensWalgreens
First Aid Contains 303 PiecesGenuine First Aid LLC
First Degree BurnThe Akshay Wellness Group, Inc.
Foille OntBlistex Corporation
Gauke Sting Relief PadGauke Healthcare (Hubei) Co., Ltd
Genuine First Aid Emergency Preparedness Contains 167 Pieces HardcaseGenuine First Aid LLC
Good Neighbor Pharmacy Emergency Preparedness and First Aid Contains 167 PiecesAmerisource Bergen
Good Neighbor Pharmacy First AidAmerisource Bergen Drug Corporation
Good Neighbor Pharmacy First Aid Contains 202 PiecesAmerisource Bergen
Good Sense Vagicaine Anti ItchL Perrigo Company
Gouttes DentairesLab Valmo EnregistrÉ, Division Of Technilab Inc.
Gouttes Pour Mal D'oreillesLab Valmo EnregistrÉ, Division Of Technilab Inc.
Green Guard Antiseptic First AidUnifirst First Aid Corporation
Green Guard Burn First AidUnifirst First Aid Corporation
GumsolKramer Novis
Henry Schein Topical Anesthetic GelAbj Custom Packaging
Image Essentials VagicaineKmart Corporation
Insect Sting Relief PadGenuine First Aid LLC
Insect Sting Relief WipesZEE MEDICAL
Insect String Relief PadYuyao Jessie Commodity Co.,Ltd.
Instant First Aid CvsCVS
Isopropyl Alcohol With BenzocaineMc Kesson Corporation
Jiffy Toothache DropsBlock Drug Company (Canada) Ltd.
Kama Sutra Pleasure BalmUltra Love Products Ltd.
Kank-ABlistex Corporation
Kanka SoftbrushBlistex Inc.
Lanacane Anti Itch Maximum StrengthCombe Incorporated
Lanacane Anti Itch Original StrengthCombe Incorporated
Lanacane Anti-bacterial First Aid SprayReckitt Benckiser (Canada) Inc
Lanacane First AidReckitt Benckiser LLC
Lanacane Maximum Strength Anti Bacterial First Aid SprayCombe Incorporated
Lanacane Maximum Strength Anti-itchReckitt Benckiser LLC
Leader Anti-itch Maximum StrengthCardinal Health
Leader Anti-itch Regular StrengthCardinal Health
Little Ouchies Little Remedies Pain ReliefMedtech Products Inc.
Lucky Oral Pain ReliefDelta Brands Inc
Makesense Feminine Anti-itchCherry Hill Sales Co
Medi-first Antiseptic First AidUnifirst First Aid Corporation
Medi-first Burn First AidUnifirst First Aid Corporation
Medi-first Ivy-rid First AidUnifirst First Aid Corporation
Medi-first Protective Coating BandageUnifirst First Aid Corporation
Medicaine Sting and BiteJames Alexander Corporation
Meditowel Antibacterial First AidMICRO CONNECTION ENTERPRISES INC
Mixed Berry Sore Throat and Cough LozengeMeijer Distribution, Inc.
Mixed Berry Sore Throat and Cough LozengesHEB
Mixed Berry Throat LozengeTopco
Mk Sting Relief PadsChangzhou Maokang Medical Products Co., Ltd
North BurnNorth Safety Products
North First Aid AntisepticNorth Safety Products
Off Bite and Itch Relief First Aid AntisepticS. C. Johnson & Son, Inc.
One Touch Advanced Topical Anesthetic Bubble GumHager Worldwide, Inc.
One Touch Advanced Topical Anesthetic CherryHager Worldwide, Inc.
One Touch Advanced Topical Anesthetic Gel Cool MintHager Worldwide, Inc.
One Touch Advanced Topical Anesthetic Strawberry IceHager Worldwide, Inc.
One Touch Topical Anesthetic GelAbj Custom Packaging
Orajel Denture PlusDel Pharmaceutics (Canada) Inc.
Orajel for Codl Sores Relief and ConcealerChurch & Dwight Co., Inc.
Orajel for Cold SoresChurch & Dwight Co., Inc.
Orajel for Cold Sores Single DoseChurch & Dwight Co., Inc.
Orajel Instant Pain Relief for Severe Toothache Maximum StrengthChurch & Dwight Co., Inc.
Orajel Instant Pain Relief MaximumChurch Dwight Co., Inc.
Orajel Instant Pain Relief Maximum StrengthChurch & Dwight Co., Inc.
Orajel Instant Pain Relief SevereChurch Dwight Co., Inc.
Orajel Instant Pain Relief Severe PMChurch Dwight Co., Inc.
Orajel Instant Pain Reliver for Canker Sores Extra Strength Pain ReliefChurch & Dwight Co., Inc.
Orajel Maximum StrengthChurch & Dwight Co., Inc.
Orajel Mouth-aidDel Pharmaceuticals Inc.
Orajel Multi-action Cold Sore MedicineDel Pharmaceutics (Canada) Inc.
Orajel Ultra Canker Sore MedicineDel Pharmaceutics (Canada) Inc.
Oral Analgesic Maximum StrengthMeijer Distribution Inc.
Oralgar DpsProduits Marc O (1987) Inc., Division Of Technilab Inc.
OrasepLlorens Pharmaceutical International Division
Oti CalProduits Francais Labs Inc.
Otic Care Antipyrine and BenzocainePure Tek Corporation
OtozinAllegis Pharmaceuticals, LLC
Oxipor LotionWhitehall Robins Inc.
Pain Relief Alcohol SwabsAmerisource Bergen
Panocaine GelHoechst Roussel Canada Inc.
Pastilles Antiseptiques JenerProduits Francais Labs Inc.
Pastilles MerolProduits Francais Labs Inc.
Permathene-12 - CapletCCA Industries, Inc.
Physicians Care Sting Relief PadDukal Corporation
Procicept B Benzocaine 20%Nocicept Technologies, Inc.
Prostat Antiseptic First AidPro Stat First Aid
Prostat Burn First AidPro Stat First Aid
Prostat Protective Coating Bandage First AidPro Stat First Aid
ProtectionGenuine First Aid LLC
Pyrocaine BurnNorth Safety Products
Quality Choice Vaginal Anti-itch Maximum StrengthChain Drug Marketing Association (Cdma)
Ready America First Aid Outdoor- 107 PiecesGenuine First Aid, LLC
Rectogel HCLaboratoire Riva Inc
Rite Aid Maximum StrengthRite Aid
Rite Aid Original Strength VagicaineRite Aid Corporation
SalinocaineMedical Products Laboratories, Inc.
Signature Care VagicaineSafeway
Slim-mint GumStella Pharmaceutical Canada Inc.
Smart Sense Vagicaine Maximum StrengthKmart Corporation
Solarcaine First Aid CreamSchering Plough Healthcare Products Canada, A Division Of Schering Canada Inc.
Solarcaine First Aid SprayBayer Inc Consumer Care
Sore Throat and CoughRugby Laboratories
Sore Throat Logenzes Sore ThroatMajor Pharmaceuticals
Sore Throat Lozenges Menthol FlavourH.J. Sutton Industries Ltd.
Sore Throat Relief Cherry FlavorSafecor Health, LLC
Sting EzeWisconsin Pharmacal Co. Llc
Sting Kure - LiqWisconsin Pharmacal Co. Llc
Sting ReliefNANTONG STRIP MEDICAL SUPPLY CO.,LTD.
Sting-eze-liqWisconsin Pharmacal Co. Llc
Stingeze Insect Bite ReliefWisconsin Pharmacal Company
Stingeze Max Insect Bite ReliefWisconsin Pharmacal Company
Stingeze With Aloe for KidsWisconsin Pharmacal Company
Tanac LiquidDel Pharmaceutics (Canada) Inc.
Throat LozengesNovopharm Limited
Topcare Sore Throat Cherry FlavorTopco Associates LLC
Topcare Sore Throat Honey Lemon FlavorTopco Associates LLC
Topicale Gel Pump Pina ColadaMedical Products Laboratories Inc.
Up and Up VagicaineTarget Corporation
Vacuant PlusStratus Pharmaceuticals
Vagi CarePersonal Care Products
Vagi-cure (maximum Strength)Sci International, Inc. Dba Continental Pharmaceuticals
Vagi-cure (regular Strength)Sci International, Inc. Dba Continental Pharmaceuticals
VagicainePersonal Care Products, Inc.
Vagicaine Maximum StrengthMeijer Distribution Inc
Vagisil Anti Itch Maximum StrengthCombe Incorporated
Vagisil Anti Itch Original StrengthCombe Incorporated
Vagisil Anti-itch Creme Regular StrengthCombe Incorporated
Vagisil Anti-itch Medicated Creme Maximum StrengthCombe Incorporated
Vagisil Anti-itch Medicated Creme Regular StrengthCombe Incorporated
Vh Essentials Sensitive Medicated CreamWisconsin Pharmacal Company
Viroxyn Professional UseQuadex Pharmaceuticals Llc
Well At Walgreens Anti-itch Maximum StrengthSci International
Your Logo Here Antiseptic First AidDixon Investments, Inc.
Your Logo Here Bandage AidDixon Investments, Inc.
Your Logo Here Burn First AidDixon Investments, Inc.
Your Logo Here Poison Ivy First AidDixon Investments, Inc.
Zap LiquidGermiphene Corporation
Zap Topical Anesthetic GelGermiphene Corporation
Zap Topical Anesthetic SprayGermiphene Corporation
Zap Topical Anesthetic Spray AerosolGermiphene Corporation
Zapotol Dentidol Oral AnalgesicProductos Zapotol Corp.
Salts
Name/CASStructureProperties
Benzocaine hydrochloride
ThumbNot applicableDBSALT001560
Categories
UNIIU3RSY48JW5
CAS number94-09-7
WeightAverage: 165.1891
Monoisotopic: 165.078978601
Chemical FormulaC9H11NO2
InChI KeyInChIKey=BLFLLBZGZJTVJG-UHFFFAOYSA-N
InChI
InChI=1S/C9H11NO2/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6H,2,10H2,1H3
IUPAC Name
ethyl 4-aminobenzoate
SMILES
CCOC(=O)C1=CC=C(N)C=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as benzoic acid esters. These are ester derivatives of benzoic acid.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBenzoic acids and derivatives
Direct ParentBenzoic acid esters
Alternative Parents
Substituents
  • Benzoate ester
  • Aminobenzoic acid or derivatives
  • Benzylether
  • Substituted aniline
  • Benzoyl
  • Aniline
  • Primary aromatic amine
  • Carboxylic acid ester
  • Monocarboxylic acid or derivatives
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Pharmacology
IndicationFor general use as a lubricant and topical anesthetic on esophagus, larynx, mouth, nasal cavity, rectum, respiratory tract or trachea, urinary tract, vagina. It is also used to suppress gag reflex.
PharmacodynamicsBenzocaine is a local anesthetic commonly used as a topical pain reliever. It is the active ingredient in many over-the-counter analgesic ointments. It is also indicated for general use as a lubricant and topical anesthetic on intratracheal catheters and pharyngeal and nasal airways to obtund the pharyngeal and tracheal reflexes; on nasogastric and endoscopic tubes; urinary catheters; laryngoscopes; proctoscopes; sigmoidoscopes and vaginal specula.
Mechanism of actionBenzocaine binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited thereby blocking the initiation and conduction of nerve impulses.
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityLD50=3040 mg/kg (rat, oral)
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Benzocaine Action PathwayDrug actionSMP00392
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9963
Blood Brain Barrier+0.9609
Caco-2 permeable+0.7814
P-glycoprotein substrateNon-substrate0.8329
P-glycoprotein inhibitor INon-inhibitor0.9589
P-glycoprotein inhibitor IINon-inhibitor0.9612
Renal organic cation transporterNon-inhibitor0.8818
CYP450 2C9 substrateNon-substrate0.8426
CYP450 2D6 substrateNon-substrate0.7934
CYP450 3A4 substrateNon-substrate0.7513
CYP450 1A2 substrateInhibitor0.9107
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.937
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7883
Ames testNon AMES toxic0.8825
CarcinogenicityCarcinogens 0.513
BiodegradationReady biodegradable0.7718
Rat acute toxicity1.7665 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9721
hERG inhibition (predictor II)Non-inhibitor0.9668
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Stripdental10 mg/1
Kit
Swabtopical
Creamtopical7.5 g/100g
Aerosol, spraytopical11.4 g/57g
Ointmenttopical5.6 g/28g
Sticktopical20 %
Geloral7.5 %
Geltopical20 %
Liquidbuccal
Solutiontopical200 mg/mL
Geltopical100 mg/g
Solutiontopical100 mg/mL
Geloral.2 g/100g
Liquidtopical.2 mg/2mL
Liquidtopical20 g/100mL
Geloral10 g/100g
Dropsotic
Solutionotic
Solutionauricular (otic)
Geltopical75 mg/g
Geltopical10 g/100g
Lozengeoral15 mg/1
Geltopical210 mg/g
Spraytopical20 mL/100mL
Geltopical200 mg/g
Geldental230 mg/mL
Gel, dentifricedental220 mg/g
Swabtopical.12 mL/1
Swabtopical60 mg/mL
Creamtopical.2 g/g
Spraytopical5 g/100g
Creamtopical5 g/100mL
Ointmenttopical
Creamtopical5 g/28g
Ointmenttopical20 %
Creamtopical71.9395789 mg/mL
Creamtopical73.9395789 mg/mL
Creamtopical4.25 g/85.05g
Geloral9 mg/mL
Geltopical.2 g/g
Lotiontopical
Creamtopical10 g/100g
Sprayoral
Tablet, orally disintegratingoral6 mg/1
Lozengeoral3 mg/1
Lozengeoral4 mg/1
Solutiontopical
Geltopical
Spongetopical
Paste, dentifricetopical200 mg/g
Gel, dentifricedental20 g/100g
Gel, dentifricedental10 g/100g
Geldental
Ointmentdental.2 g/mL
Gelbuccal; topical
Ointmenttopical1.27 g/100g
Geltopical7.5 %
Spraybuccal; oral20 %
Metered-dose aerosoltopical
Liquidrectal
Liquidoral
Liquidoral7.5 mg/100mg
Sprayoral7.5 mg/100mL
Spraytopical
Patchtopical
Geldental6 g/30g
Spray, metereddental11.4 g/57g
Geldental20 %
Liquiddental20 %
Creamtopical
Geldental200 mg/g
Solutionoral
Creamtopical4.5 g/100g
Spraydental; periodontal183 mg/g
Liquidtopical20 %
Geldental; periodontal200 mg/g
Spraydental; oral; periodontal200 mg/g
Geldental; oral; periodontal200 mg/g
Liquiddental; oral; periodontal200 mg/g
Aerosoldental; topical21.9 %
Solutiontopical150 mg/mL
Liquidtopical6 g/100g
Liquiddental
Creamtopical5 %
Liquidbuccal; topical
Liquidbuccal200 mg/mL
Geloral
Geloral20 g/100g
Granuleoral6 mg/1
Liquidoral200 mg/mL
Geltopical3 g/100mL
Geltopical2.13 g/28.35g
Swabtopical.12 g/.6mL
Swabtopical.12 g/g
Clothtopical
Liquidoral200 mg/g
Geltopical7.5 g/100g
Liquidtopical2.1 mg/30mL
Creamtopical200 mg/mL
Powder, for solutionoral90 mg/1
Geldental; topical
Gelbuccal
Geldental; oral6.4 g/32g
Spray, metereddental; oral; topical12 g/60g
Paste, dentifricedental19.8 mg/g
Liquiddental205 mg
Geldental200 mg
Liquidtopical
Swabtopical.2 mL/mL
Liquidtopical200 mg/g
Swabtopical.075 mL/mL
Kit
Liquidtopical.2 mL/mL
Pastetopical
Geloral.2 mL/mL
Geloral200 mg/g
Drops
Liquidtopical.009 mg/mL
Geloral; topical
Lozenge
Solution/ dropsauricular (otic)200 mg/mL
Tabletoral
Geltopical5 g/100mL
Liquidtopical4 g/100mL
Geldental221 mg/g
Geldental; topical20 %
Geltopical20 g/100g
Geltopical20 1/100g
Aerosol, spraytopical
Ointmentrectal
Liquidtopical200 mg/mL
Geloral200 mg/mL
Gel, dentifriceoral
Gel, dentifriceoral20 g/100g
Liquiddental20 g/100g
Swabtopical15 %
Clothtopical.0543 g/1
Kittopical
Liquidoral20 g/100g
Geloral75 mg/g
Aerosol, spraytopical1.125 g/15g
Geltopical5.06 g/67.5g
Geltopical5.07 g/67.5g
Syrupdental1.8 %
Gumoral
Aerosoltopical
Lozengeoral
Swabtopical6 g/100mL
Swabtopical.06 mg/1
Swabtopical.06 mL/mL
Swaboral20 %
Liquidoral1.3 mg/13mL
Ointmenttopical3.5 g/100g
Liquidoral50 mg/mL
Geloral; topical20 %
Geloral; topical200 mg
Geldental220 mg/g
Geldental6.96 g/30mL
Enemarectal
Gel, dentifriceoral7.5 g/100g
Ointmenttopical5 mg/g
Paste, dentifricetopical20 g/100g
Ointmenttopical20 g/100g
Spray, meteredtopical
Aerosoloral
Geltopical10 %
Swabtopical20 %
Geltopical.1 g/g
Prices
Unit descriptionCostUnit
Americaine Anesthetic 20% Gel 28 gm Tube22.99USD tube
Americaine 20% ear drops1.26USD ml
Oticaine 20% ear drops0.83USD ml
Americaine lubricant0.71USD g
Hurricaine 20% liquid swab0.6USD swab
Hurricaine 20% spray0.52USD ml
Anbesol baby 7.5% gel0.41USD g
Cepacol 6 mg fizzlers tablet0.39USD tablet
Benzocaine powder0.09USD g
Dermoplast pain relieving spry0.07USD ml
Dermoplast spray0.07USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point92 °CPhysProp
boiling point310 °CPhysProp
water solubility1310 mg/L (at 30 °C)YALKOWSKY,SH & HE,Y (2003)
logP1.86HANSCH,C ET AL. (1995)
pKa2.51 (at 25 °C)PERRIN,DD (1965)
Predicted Properties
PropertyValueSource
Water Solubility2.85 mg/mLALOGPS
logP2.2ALOGPS
logP1.5ChemAxon
logS-1.8ALOGPS
pKa (Strongest Basic)2.78ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area52.32 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity47.53 m3·mol-1ChemAxon
Polarizability17.46 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (7.74 KB)
Spectra
Spectrum TypeDescriptionSplash Key
GC-MSGC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (1 TMS)splash10-00dl-0980000000-9bd6d020be04ce49bd3eView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-00kr-0900000000-b54aebb77e7a69ada07cView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-014i-5900000000-ce90658bd0fc66df820dView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-03xu-9100000000-5179b7804d2c59e71aa4View in MoNA
LC-MS/MSLC-MS/MS Spectrum - EI-B (HITACHI RMU-7M) , Positivesplash10-00di-4900000000-9341302295e361a20bfdView in MoNA
LC-MS/MSLC-MS/MS Spectrum - EI-B (HITACHI RMU-7) , Positivesplash10-0109-9400000000-8e31c925b871e0f0299eView in MoNA
LC-MS/MSLC-MS/MS Spectrum - EI-B (HITACHI RMU-6D) , Positivesplash10-0109-9400000000-c755b4e5336a2867357eView in MoNA
LC-MS/MSLC-MS/MS Spectrum - EI-B (HITACHI M-60) , Positivesplash10-01b9-1900000000-57d39b512bc5bdbb4987View in MoNA
LC-MS/MSLC-MS/MS Spectrum - CI-B (HITACHI M-60) , Positivesplash10-014i-0900000000-49302e8e4fd5158a36daView in MoNA
LC-MS/MSLC-MS/MS Spectrum - EI-B (JEOL JMS-DX-300) , Positivesplash10-00di-5900000000-dcd2847110af7c87bf18View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positivesplash10-014i-0900000000-a0f10abbe67842c2c958View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positivesplash10-00du-5900000000-43a89461a4d9cc5d1409View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positivesplash10-00dl-9600000000-049e2653cbbf24aaf010View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positivesplash10-002f-9100000000-6fbc7720b326773643afView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positivesplash10-00ou-9000000000-d7f7622c3a270c5ffcbbView in MoNA
MSMass Spectrum (Electron Ionization)splash10-00xr-6900000000-0594451f3b181ab3c883View in MoNA
1D NMR1H NMR SpectrumNot Available
1D NMR1H NMR SpectrumNot Available
1D NMR13C NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesR02AD01D04AB04N01BA05C05AD03
AHFS Codes
  • 52:16.00
  • 84:08.00
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (73.3 KB)
Interactions
Drug Interactions
Drug
7-NitroindazoleThe risk or severity of adverse effects can be increased when Benzocaine is combined with 7-Nitroindazole.
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Benzocaine.
AcepromazineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Acepromazine.
AceprometazineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Aceprometazine.
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Benzocaine.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Benzocaine.
adipiplonThe risk or severity of adverse effects can be increased when Benzocaine is combined with adipiplon.
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Benzocaine.
AgomelatineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Agomelatine.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Benzocaine.
AlfaxaloneThe risk or severity of adverse effects can be increased when Benzocaine is combined with Alfaxalone.
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Benzocaine.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Benzocaine.
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Benzocaine is combined with Alphacetylmethadol.
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Benzocaine.
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Benzocaine.
AmisulprideThe risk or severity of adverse effects can be increased when Benzocaine is combined with Amisulpride.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Benzocaine.
AmitriptylineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Benzocaine.
AmobarbitalThe risk or severity of adverse effects can be increased when Benzocaine is combined with Amobarbital.
AmoxapineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Amoxapine.
AmperozideThe risk or severity of adverse effects can be increased when Benzocaine is combined with Amperozide.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Benzocaine.
AripiprazoleThe risk or severity of adverse effects can be increased when Benzocaine is combined with Aripiprazole.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Benzocaine.
ArticaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Articaine.
AsenapineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Asenapine.
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Benzocaine.
AtenololThe serum concentration of Atenolol can be increased when it is combined with Benzocaine.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Benzocaine.
AzaperoneThe risk or severity of adverse effects can be increased when Benzocaine is combined with Azaperone.
AzelastineBenzocaine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Benzocaine.
BaclofenThe risk or severity of adverse effects can be increased when Benzocaine is combined with Baclofen.
BarbitalThe risk or severity of adverse effects can be increased when Benzocaine is combined with Barbital.
Benzyl alcoholThe risk or severity of adverse effects can be increased when Benzocaine is combined with Benzyl alcohol.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Benzocaine.
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Benzocaine.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Benzocaine.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Benzocaine.
BrexpiprazoleThe risk or severity of adverse effects can be increased when Benzocaine is combined with Brexpiprazole.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Benzocaine.
BrimonidineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Brimonidine.
BromazepamThe risk or severity of adverse effects can be increased when Benzocaine is combined with Bromazepam.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Benzocaine.
BrompheniramineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Brompheniramine.
BrotizolamThe risk or severity of adverse effects can be increased when Benzocaine is combined with Brotizolam.
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Benzocaine.
BuprenorphineThe risk or severity of adverse effects can be increased when Buprenorphine is combined with Benzocaine.
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Benzocaine.
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Benzocaine.
ButacaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Butacaine.
ButalbitalThe risk or severity of adverse effects can be increased when Benzocaine is combined with Butalbital.
ButambenThe risk or severity of adverse effects can be increased when Benzocaine is combined with Butamben.
ButethalThe risk or severity of adverse effects can be increased when Benzocaine is combined with Butethal.
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Benzocaine.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Benzocaine.
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Benzocaine.
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Benzocaine.
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Benzocaine.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Benzocaine.
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Benzocaine.
CarbinoxamineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Carbinoxamine.
CarfentanilThe risk or severity of adverse effects can be increased when Benzocaine is combined with Carfentanil.
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Benzocaine.
CarisoprodolThe risk or severity of adverse effects can be increased when Benzocaine is combined with Carisoprodol.
CeritinibThe serum concentration of Ceritinib can be increased when it is combined with Benzocaine.
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Benzocaine.
CetirizineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Cetirizine.
Chloral hydrateThe risk or severity of adverse effects can be increased when Benzocaine is combined with Chloral hydrate.
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Benzocaine.
ChlormezanoneThe risk or severity of adverse effects can be increased when Benzocaine is combined with Chlormezanone.
ChloroprocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Chloroprocaine.
ChlorphenamineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Chlorphenamine.
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Benzocaine.
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Benzocaine.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Benzocaine is combined with Chlorprothixene.
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Benzocaine is combined with Chlorzoxazone.
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Benzocaine.
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Benzocaine.
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Benzocaine.
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Benzocaine.
CitalopramThe risk or severity of adverse effects can be increased when Benzocaine is combined with Citalopram.
ClarithromycinThe serum concentration of Clarithromycin can be increased when it is combined with Benzocaine.
ClemastineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Clemastine.
ClidiniumThe risk or severity of adverse effects can be increased when Benzocaine is combined with Clidinium.
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Benzocaine.
ClobazamThe risk or severity of adverse effects can be increased when Clobazam is combined with Benzocaine.
clomethiazoleThe risk or severity of adverse effects can be increased when Benzocaine is combined with clomethiazole.
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Benzocaine.
ClomipramineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Clomipramine.
ClonazepamThe risk or severity of adverse effects can be increased when Benzocaine is combined with Clonazepam.
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Benzocaine.
ClonidineThe risk or severity of adverse effects can be increased when Clonidine is combined with Benzocaine.
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Benzocaine.
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Benzocaine.
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Benzocaine.
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Benzocaine.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Benzocaine.
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Benzocaine.
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Benzocaine.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Benzocaine.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Benzocaine.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Benzocaine.
CyclizineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Cyclizine.
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Benzocaine.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Benzocaine.
CyproheptadineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Cyproheptadine.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Benzocaine.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Benzocaine.
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Benzocaine.
DantroleneThe risk or severity of adverse effects can be increased when Benzocaine is combined with Dantrolene.
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Benzocaine.
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Benzocaine.
DapoxetineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Dapoxetine.
DapsoneThe risk or severity of adverse effects can be increased when Dapsone is combined with Benzocaine.
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Benzocaine.
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Benzocaine.
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Benzocaine.
deramciclaneThe risk or severity of adverse effects can be increased when Benzocaine is combined with deramciclane.
DesfluraneThe risk or severity of adverse effects can be increased when Benzocaine is combined with Desflurane.
DesipramineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Desipramine.
DesloratadineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Desloratadine.
DetomidineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Detomidine.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Benzocaine.
DexbrompheniramineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Dexbrompheniramine.
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Benzocaine.
DextromoramideThe risk or severity of adverse effects can be increased when Benzocaine is combined with Dextromoramide.
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Benzocaine.
DezocineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Dezocine.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Benzocaine.
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Benzocaine.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Benzocaine.
DifenoxinThe risk or severity of adverse effects can be increased when Benzocaine is combined with Difenoxin.
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Benzocaine.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Benzocaine.
DihydrocodeineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Dihydrocodeine.
DihydroetorphineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Dihydroetorphine.
DihydromorphineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Dihydromorphine.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Benzocaine.
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Benzocaine.
DimenhydrinateThe risk or severity of adverse effects can be increased when Benzocaine is combined with Dimenhydrinate.
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Benzocaine.
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Benzocaine.
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Benzocaine.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Benzocaine.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Benzocaine.
DoramectinThe risk or severity of adverse effects can be increased when Benzocaine is combined with Doramectin.
DoxepinThe risk or severity of adverse effects can be increased when Benzocaine is combined with Doxepin.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Benzocaine.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Benzocaine.
DoxylamineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Doxylamine.
DPDPEThe risk or severity of adverse effects can be increased when Benzocaine is combined with DPDPE.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Benzocaine.
DroperidolThe risk or severity of adverse effects can be increased when Droperidol is combined with Benzocaine.
DrotebanolThe risk or severity of adverse effects can be increased when Benzocaine is combined with Drotebanol.
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Benzocaine.
EcgonineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Ecgonine.
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Benzocaine is combined with ECGONINE METHYL ESTER.
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Benzocaine.
EfavirenzThe risk or severity of adverse effects can be increased when Benzocaine is combined with Efavirenz.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Benzocaine.
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Benzocaine.
EntacaponeThe risk or severity of adverse effects can be increased when Benzocaine is combined with Entacapone.
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Benzocaine.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Benzocaine.
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Benzocaine.
EscitalopramThe risk or severity of adverse effects can be increased when Benzocaine is combined with Escitalopram.
EstazolamThe risk or severity of adverse effects can be increased when Benzocaine is combined with Estazolam.
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Benzocaine.
EstriolThe serum concentration of Estriol can be increased when it is combined with Benzocaine.
EstroneThe serum concentration of Estrone can be increased when it is combined with Benzocaine.
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Benzocaine.
EthanolBenzocaine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Benzocaine.
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Benzocaine.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Benzocaine.
EthosuximideThe risk or severity of adverse effects can be increased when Benzocaine is combined with Ethosuximide.
EthotoinThe risk or severity of adverse effects can be increased when Benzocaine is combined with Ethotoin.
Ethyl carbamateThe risk or severity of adverse effects can be increased when Benzocaine is combined with Ethyl carbamate.
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Benzocaine is combined with Ethyl loflazepate.
EthylmorphineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Ethylmorphine.
EtidocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Etidocaine.
EtifoxineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Etifoxine.
EtizolamThe risk or severity of adverse effects can be increased when Benzocaine is combined with Etizolam.
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Benzocaine.
EtoperidoneThe risk or severity of adverse effects can be increased when Benzocaine is combined with Etoperidone.
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Benzocaine.
EtorphineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Etorphine.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Benzocaine.
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Benzocaine.
EzogabineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Ezogabine.
FelbamateThe risk or severity of adverse effects can be increased when Benzocaine is combined with Felbamate.
FencamfamineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Fencamfamine.
FenfluramineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Fenfluramine.
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Benzocaine.
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Benzocaine.
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Benzocaine.
FexofenadineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Benzocaine.
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Benzocaine.
FlibanserinThe risk or severity of adverse effects can be increased when Benzocaine is combined with Flibanserin.
FludiazepamThe risk or severity of adverse effects can be increased when Benzocaine is combined with Fludiazepam.
FlunarizineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Flunarizine.
FlunitrazepamThe risk or severity of adverse effects can be increased when Benzocaine is combined with Flunitrazepam.
FluoxetineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Fluoxetine.
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Benzocaine.
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Benzocaine.
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Benzocaine.
FluspirileneThe risk or severity of adverse effects can be increased when Benzocaine is combined with Fluspirilene.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Benzocaine.
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Benzocaine is combined with Fluticasone Propionate.
FluvoxamineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Fluvoxamine.
FosphenytoinThe risk or severity of adverse effects can be increased when Benzocaine is combined with Fosphenytoin.
FospropofolThe risk or severity of adverse effects can be increased when Benzocaine is combined with Fospropofol.
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Benzocaine.
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Benzocaine is combined with gabapentin enacarbil.
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Benzocaine is combined with Gamma Hydroxybutyric Acid.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Benzocaine.
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Benzocaine.
GlutethimideThe risk or severity of adverse effects can be increased when Benzocaine is combined with Glutethimide.
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Benzocaine.
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Benzocaine.
GuanfacineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Guanfacine.
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Benzocaine.
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Benzocaine.
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Benzocaine.
HalothaneThe risk or severity of adverse effects can be increased when Benzocaine is combined with Halothane.
HeroinThe risk or severity of adverse effects can be increased when Benzocaine is combined with Heroin.
HexobarbitalThe risk or severity of adverse effects can be increased when Benzocaine is combined with Hexobarbital.
HyaluronidaseThe risk or severity of adverse effects can be increased when Hyaluronidase is combined with Benzocaine.
HydrocodoneThe risk or severity of adverse effects can be increased when Hydrocodone is combined with Benzocaine.
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Benzocaine.
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Benzocaine.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Benzocaine.
HydroxyzineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Hydroxyzine.
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Benzocaine.
IdelalisibThe serum concentration of Idelalisib can be increased when it is combined with Benzocaine.
IloperidoneThe risk or severity of adverse effects can be increased when Benzocaine is combined with Iloperidone.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Benzocaine.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Benzocaine.
ImipramineThe risk or severity of adverse effects can be increased when Imipramine is combined with Benzocaine.
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Benzocaine.
IndalpineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Indalpine.
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Benzocaine.
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Benzocaine.
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Benzocaine.
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Benzocaine.
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Benzocaine.
KetamineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Ketamine.
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Benzocaine.
KetazolamThe risk or severity of adverse effects can be increased when Ketazolam is combined with Benzocaine.
KetobemidoneThe risk or severity of adverse effects can be increased when Benzocaine is combined with Ketobemidone.
KetoconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Benzocaine.
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Benzocaine.
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Benzocaine.
LamotrigineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Benzocaine.
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Benzocaine.
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Benzocaine.
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Benzocaine.
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Benzocaine.
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Benzocaine.
LevetiracetamThe risk or severity of adverse effects can be increased when Levetiracetam is combined with Benzocaine.
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Benzocaine.
LevocabastineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Levocabastine.
LevocetirizineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Levocetirizine.
LevodopaThe risk or severity of adverse effects can be increased when Benzocaine is combined with Levodopa.
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Benzocaine.
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Benzocaine is combined with Levomethadyl Acetate.
LevomilnacipranThe risk or severity of adverse effects can be increased when Benzocaine is combined with Levomilnacipran.
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Benzocaine.
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Benzocaine.
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Benzocaine.
LithiumThe risk or severity of adverse effects can be increased when Benzocaine is combined with Lithium.
LofentanilThe risk or severity of adverse effects can be increased when Benzocaine is combined with Lofentanil.
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Benzocaine.
LoratadineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Loratadine.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Benzocaine.
LosartanThe serum concentration of Losartan can be increased when it is combined with Benzocaine.
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Benzocaine.
Lu AA21004The risk or severity of adverse effects can be increased when Benzocaine is combined with Lu AA21004.
LurasidoneThe risk or severity of adverse effects can be increased when Benzocaine is combined with Lurasidone.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Benzocaine.
Magnesium SulfateThe risk or severity of adverse effects can be increased when Benzocaine is combined with Magnesium Sulfate.
MannitolThe serum concentration of Mannitol can be increased when it is combined with Benzocaine.
MaprotilineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Maprotiline.
MeclizineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Meclizine.
MedetomidineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Medetomidine.
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Benzocaine.
MelperoneThe risk or severity of adverse effects can be increased when Benzocaine is combined with Melperone.
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Benzocaine.
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Benzocaine.
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Benzocaine.
MetaxaloneThe risk or severity of adverse effects can be increased when Benzocaine is combined with Metaxalone.
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Benzocaine.
Methadyl AcetateThe risk or severity of adverse effects can be increased when Benzocaine is combined with Methadyl Acetate.
MethapyrileneThe risk or severity of adverse effects can be increased when Benzocaine is combined with Methapyrilene.
MethaqualoneThe risk or severity of adverse effects can be increased when Benzocaine is combined with Methaqualone.
MethocarbamolThe risk or severity of adverse effects can be increased when Benzocaine is combined with Methocarbamol.
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Benzocaine.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Benzocaine.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Methotrimeprazine.
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Benzocaine.
MethsuximideThe risk or severity of adverse effects can be increased when Benzocaine is combined with Methsuximide.
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Benzocaine.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Benzocaine.
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Benzocaine.
MetyrosineBenzocaine may increase the sedative activities of Metyrosine.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Benzocaine.
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Benzocaine.
MilnacipranThe risk or severity of adverse effects can be increased when Benzocaine is combined with Milnacipran.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Benzocaine.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Benzocaine.
MirtazapineBenzocaine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MirtazapineThe risk or severity of adverse effects can be increased when Mirtazapine is combined with Benzocaine.
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Benzocaine.
MolindoneThe risk or severity of adverse effects can be increased when Benzocaine is combined with Molindone.
MorphineThe serum concentration of Morphine can be increased when it is combined with Benzocaine.
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Benzocaine.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Benzocaine.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Benzocaine.
NabiloneThe risk or severity of adverse effects can be increased when Benzocaine is combined with Nabilone.
NadololThe serum concentration of Nadolol can be increased when it is combined with Benzocaine.
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Benzocaine.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Benzocaine.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Benzocaine.
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Benzocaine.
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Benzocaine.
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Benzocaine.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Benzocaine.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Benzocaine.
NitrazepamThe risk or severity of adverse effects can be increased when Benzocaine is combined with Nitrazepam.
Nitric OxideThe risk or severity of adverse effects can be increased when Nitric Oxide is combined with Benzocaine.
Nitrous oxideThe risk or severity of adverse effects can be increased when Benzocaine is combined with Nitrous oxide.
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Benzocaine.
NormethadoneThe risk or severity of adverse effects can be increased when Benzocaine is combined with Normethadone.
NortriptylineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Nortriptyline.
OlanzapineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Olanzapine.
OlopatadineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Olopatadine.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Benzocaine.
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Benzocaine.
OpiumThe risk or severity of adverse effects can be increased when Benzocaine is combined with Opium.
OrphenadrineBenzocaine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OrphenadrineThe risk or severity of adverse effects can be increased when Orphenadrine is combined with Benzocaine.
OsanetantThe risk or severity of adverse effects can be increased when Benzocaine is combined with Osanetant.
OsimertinibThe serum concentration of Osimertinib can be increased when it is combined with Benzocaine.
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Benzocaine.
OxprenololThe risk or severity of adverse effects can be increased when Benzocaine is combined with Oxprenolol.
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Benzocaine.
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Benzocaine.
OxymorphoneThe risk or severity of adverse effects can be increased when Benzocaine is combined with Oxymorphone.
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Benzocaine.
PaliperidoneThe risk or severity of adverse effects can be increased when Benzocaine is combined with Paliperidone.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Benzocaine.
ParaldehydeBenzocaine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParaldehydeThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Benzocaine.
ParoxetineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Paroxetine.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Benzocaine.
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Benzocaine.
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Benzocaine.
PerampanelThe risk or severity of adverse effects can be increased when Benzocaine is combined with Perampanel.
PerospironeThe risk or severity of adverse effects can be increased when Benzocaine is combined with Perospirone.
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Benzocaine.
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Benzocaine.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Benzocaine.
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Benzocaine.
PhenoxyethanolThe risk or severity of adverse effects can be increased when Benzocaine is combined with Phenoxyethanol.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Benzocaine.
PhenytoinThe risk or severity of adverse effects can be increased when Phenytoin is combined with Benzocaine.
PimozideThe risk or severity of adverse effects can be increased when Benzocaine is combined with Pimozide.
PipamperoneThe risk or severity of adverse effects can be increased when Benzocaine is combined with Pipamperone.
PipotiazineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Pipotiazine.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Benzocaine.
PizotifenThe risk or severity of adverse effects can be increased when Benzocaine is combined with Pizotifen.
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Benzocaine.
PomalidomideThe risk or severity of adverse effects can be increased when Pomalidomide is combined with Benzocaine.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Benzocaine.
PramipexoleBenzocaine may increase the sedative activities of Pramipexole.
PramocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Pramocaine.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Benzocaine.
PrazepamThe risk or severity of adverse effects can be increased when Benzocaine is combined with Prazepam.
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Benzocaine.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Benzocaine.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Benzocaine.
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Benzocaine.
PrilocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Prilocaine.
PrimidoneThe risk or severity of adverse effects can be increased when Benzocaine is combined with Primidone.
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Benzocaine.
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Benzocaine.
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Benzocaine.
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Benzocaine.
PromethazineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Promethazine.
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Benzocaine.
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Benzocaine.
PropoxycaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Propoxycaine.
PropranololThe serum concentration of Propranolol can be increased when it is combined with Benzocaine.
ProtriptylineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Protriptyline.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Benzocaine.
PSD502The risk or severity of adverse effects can be increased when Benzocaine is combined with PSD502.
QuazepamThe risk or severity of adverse effects can be increased when Benzocaine is combined with Quazepam.
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Benzocaine.
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Benzocaine.
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Benzocaine.
QuinineThe serum concentration of Quinine can be increased when it is combined with Benzocaine.
RamelteonThe risk or severity of adverse effects can be increased when Benzocaine is combined with Ramelteon.
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Benzocaine.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Benzocaine.
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Benzocaine.
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Benzocaine.
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Benzocaine.
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Benzocaine.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Benzocaine.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Benzocaine.
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Benzocaine.
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Benzocaine.
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Benzocaine.
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Benzocaine.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Benzocaine.
RomifidineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Romifidine.
RopiniroleBenzocaine may increase the sedative activities of Ropinirole.
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Benzocaine.
RotigotineBenzocaine may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Benzocaine.
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Benzocaine is combined with S-Ethylisothiourea.
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Benzocaine.
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Benzocaine.
ScopolamineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Scopolamine.
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Benzocaine.
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Benzocaine.
SertindoleThe risk or severity of adverse effects can be increased when Benzocaine is combined with Sertindole.
SertralineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Sertraline.
SevofluraneThe risk or severity of adverse effects can be increased when Benzocaine is combined with Sevoflurane.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Benzocaine.
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Benzocaine.
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Benzocaine.
Sodium NitriteThe risk or severity of adverse effects can be increased when Benzocaine is combined with Sodium Nitrite.
Sodium oxybateThe risk or severity of adverse effects can be increased when Benzocaine is combined with Sodium oxybate.
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Benzocaine.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Benzocaine.
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Benzocaine.
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Benzocaine.
StiripentolThe risk or severity of adverse effects can be increased when Benzocaine is combined with Stiripentol.
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Benzocaine.
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Benzocaine.
SuvorexantThe risk or severity of adverse effects can be increased when Benzocaine is combined with Suvorexant.
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Benzocaine.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Benzocaine.
TapentadolThe risk or severity of adverse effects can be increased when Benzocaine is combined with Tapentadol.
TasimelteonThe risk or severity of adverse effects can be increased when Benzocaine is combined with Tasimelteon.
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Benzocaine.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Benzocaine.
Technetium Tc-99m tilmanoceptBenzocaine may decrease effectiveness of Technetium Tc-99m tilmanocept as a diagnostic agent.
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Benzocaine.
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Benzocaine.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Benzocaine.
TetrabenazineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Tetrabenazine.
TetracaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Tetracaine.
TetrodotoxinThe risk or severity of adverse effects can be increased when Benzocaine is combined with Tetrodotoxin.
ThalidomideBenzocaine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Benzocaine.
ThiamylalThe risk or severity of adverse effects can be increased when Benzocaine is combined with Thiamylal.
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Benzocaine.
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Benzocaine.
ThiothixeneThe risk or severity of adverse effects can be increased when Benzocaine is combined with Thiothixene.
TiagabineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Tiagabine.
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Benzocaine.
TiletamineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Tiletamine.
TimololThe serum concentration of Timolol can be increased when it is combined with Benzocaine.
TizanidineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Tizanidine.
TolcaponeThe risk or severity of adverse effects can be increased when Benzocaine is combined with Tolcapone.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Benzocaine.
TopiramateThe risk or severity of adverse effects can be increased when Benzocaine is combined with Topiramate.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Benzocaine.
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Benzocaine.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Benzocaine.
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Trans-2-Phenylcyclopropylamine.
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Benzocaine.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Benzocaine.
TrazodoneThe risk or severity of adverse effects can be increased when Benzocaine is combined with Trazodone.
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Benzocaine.
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Benzocaine.
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Benzocaine.
TrimipramineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Trimipramine.
TriprolidineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Triprolidine.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Benzocaine.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Benzocaine.
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Benzocaine.
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Benzocaine.
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Benzocaine.
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Benzocaine.
VigabatrinThe risk or severity of adverse effects can be increased when Benzocaine is combined with Vigabatrin.
VilazodoneThe risk or severity of adverse effects can be increased when Benzocaine is combined with Vilazodone.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Benzocaine.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Benzocaine.
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Benzocaine.
VortioxetineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Vortioxetine.
XylazineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Xylazine.
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Benzocaine.
ZiconotideThe risk or severity of adverse effects can be increased when Benzocaine is combined with Ziconotide.
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Benzocaine.
ZimelidineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Zimelidine.
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Benzocaine.
ZolazepamThe risk or severity of adverse effects can be increased when Benzocaine is combined with Zolazepam.
ZolpidemThe risk or severity of adverse effects can be increased when Zolpidem is combined with Benzocaine.
ZonisamideThe risk or severity of adverse effects can be increased when Benzocaine is combined with Zonisamide.
ZopicloneThe risk or severity of adverse effects can be increased when Benzocaine is combined with Zopiclone.
ZotepineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Zotepine.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Benzocaine is combined with Zuclopenthixol.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Voltage-gated sodium channel activity
Specific Function:
Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.
Gene Name:
SCN10A
Uniprot ID:
Q9Y5Y9
Molecular Weight:
220623.605 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Ahern CA, Eastwood AL, Dougherty DA, Horn R: Electrostatic contributions of aromatic residues in the local anesthetic receptor of voltage-gated sodium channels. Circ Res. 2008 Jan 4;102(1):86-94. Epub 2007 Oct 25. [PubMed:17967784 ]
  4. Hanck DA, Nikitina E, McNulty MM, Fozzard HA, Lipkind GM, Sheets MF: Using lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity. Circ Res. 2009 Aug 28;105(5):492-9. doi: 10.1161/CIRCRESAHA.109.198572. Epub 2009 Aug 6. [PubMed:19661462 ]
  5. Lipkind GM, Fozzard HA: Molecular modeling of local anesthetic drug binding by voltage-gated sodium channels. Mol Pharmacol. 2005 Dec;68(6):1611-22. Epub 2005 Sep 20. [PubMed:16174788 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Triglyceride lipase activity
Specific Function:
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity,...
Gene Name:
CES1
Uniprot ID:
P23141
Molecular Weight:
62520.62 Da
References
  1. Bell FP: The effect of local anesthetics on arterial lipid metabolism. Inhibition of sterol esterification in vitro. Atherosclerosis. 1981 Jan-Feb;38(1-2):81-8. [PubMed:7470208 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. [PubMed:14985103 ]
Comments
comments powered by Disqus
Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23