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Identification
NameIdelalisib
Accession NumberDB09054
TypeSmall Molecule
GroupsApproved
DescriptionIdelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination with rituximab in patients for whom rituximab alone would be considered appropriate therapy due to other co-morbidities, while in the treatment of FL and SLL it is intended to be used in patients who have received at least two prior systemic therapies. More specifically, idelalisib targets P110δ, the delta isoform of the enzyme phosphatidylinositol-4,5-bisphosphate 3-kinase, also known as PI-3K. The PI-3Ks are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. In contrast to the other class IA PI3Ks p110α and p110β, p110δ is principally expressed in leukocytes (white blood cells) and is important for the function of T cells, B cell, mast cells and neutrophils. By inhibiting this enzyme, idelalisib induces apoptosis of malignant cells and inhibits several cell signaling pathways, including B-cell receptor (BCR) signaling and C-X-C chemokine receptors type 5 and type 4 signalling, which are involved in trafficking and homing of B-cells to the lymph nodes and bone marrow. Treatment of lymphoma cells with idelalisib has been shown to result in inhibition of chemotaxis and adhesion, and reduced cell viability.
Structure
Thumb
Synonyms
5-Fluoro-3-phenyl-2-((S)-1-(9H-purin-6-ylamino)-propyl)-3H-quinazolin-4-one
5-fluoro-3-phenyl-2-[(1S)-1-(3H-purin-6-ylamino)propyl]quinazolin-4(3H)-one
External Identifiers
  • CAL 101
  • CAL-101
  • CAL101
  • GS 1101
  • GS-1101
  • GS1101
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Zydeligtablet, film coated100 mg/1oralGilead Sciences, Inc.2014-07-23Not applicableUs
ZydeligFilm-coated tablet100 mgOral useGilead Sciences International Ltd2014-09-18Not applicableEu
Zydeligtablet, film coated150 mg/1oralGilead Sciences, Inc.2014-07-23Not applicableUs
ZydeligFilm-coated tablet150 mgOral useGilead Sciences International Ltd2014-09-18Not applicableEu
Zydeligtablet100 mgoralGilead Sciences Canada Inc2015-04-21Not applicableCanada
Zydeligtablet150 mgoralGilead Sciences Canada Inc2015-04-21Not applicableCanada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIYG57I8T5M0
CAS number870281-82-6
WeightAverage: 415.432
Monoisotopic: 415.155686391
Chemical FormulaC22H18FN7O
InChI KeyIFSDAJWBUCMOAH-HNNXBMFYSA-N
InChI
InChI=1S/C22H18FN7O/c1-2-15(28-20-18-19(25-11-24-18)26-12-27-20)21-29-16-10-6-9-14(23)17(16)22(31)30(21)13-7-4-3-5-8-13/h3-12,15H,2H2,1H3,(H2,24,25,26,27,28)/t15-/m0/s1
IUPAC Name
5-fluoro-3-phenyl-2-[(1S)-1-[(9H-purin-6-yl)amino]propyl]-3,4-dihydroquinazolin-4-one
SMILES
[H][C@@](CC)(NC1=NC=NC2=C1N=CN2)C1=NC2=CC=CC(F)=C2C(=O)N1C1=CC=CC=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as 6-alkylaminopurines. These are compounds that contain an alkylamine group attached at the 6-position of a purine. Purine is a bicyclic aromatic compound made up of a pyrimidine ring fused to an imidazole ring.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassImidazopyrimidines
Sub ClassPurines and purine derivatives
Direct Parent6-alkylaminopurines
Alternative Parents
Substituents
  • 6-alkylaminopurine
  • Quinazoline
  • Pyrimidone
  • Secondary aliphatic/aromatic amine
  • Aryl fluoride
  • Aryl halide
  • Monocyclic benzene moiety
  • Pyrimidine
  • Benzenoid
  • Imidolactam
  • Imidazole
  • Heteroaromatic compound
  • Azole
  • Vinylogous halide
  • Lactam
  • Secondary amine
  • Azacycle
  • Hydrocarbon derivative
  • Organic oxide
  • Organooxygen compound
  • Organonitrogen compound
  • Organofluoride
  • Organohalogen compound
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationIdelalisib is indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination with rituximab in patients for whom rituximab alone would be considered appropriate therapy due to other co-morbidities, while in the treatment of FL and SLL it is intended to be used in patients who have received at least two prior systemic therapies.
PharmacodynamicsNot Available
Mechanism of actionIdelalisib specifically inhibits P110δ, the delta isoform of the enzyme phosphatidylinositol-4,5-bisphosphate 3-kinase, also known as PI-3K. The PI-3Ks are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. In contrast to the other class IA PI3Ks p110α and p110β, p110δ is principally expressed in leukocytes (white blood cells) and is important for the function of T cells, B cell, mast cells and neutrophils. By inhibiting this enzyme, idelalisib induces apoptosis of malignant cells and inhibits several cell signaling pathways, including B-cell receptor (BCR) signaling and C-X-C chemokine receptors type 5 and type 4 signalling, which are involved in trafficking and homing of B-cells to the lymph nodes and bone marrow. Treatment of lymphoma cells with idelalisib has been shown to result in inhibition of chemotaxis and adhesion, and reduced cell viability.
Related Articles
AbsorptionFollowing oral administration, the median Tmax was observed at 1.5 hours.
Volume of distribution

23 L

Protein bindingIdelalisib is greater than 84% bound to human plasma proteins with no concentration dependence.
Metabolism

Idelalisib is metabolized by aldehyde oxidase and CYP3A to its major metabolite GS-563117, which is inactive against P110δ. Idelalisib is also metabolized to a minor extent by UGT1A4.

SubstrateEnzymesProduct
Idelalisib
GS-563117Details
Route of eliminationFollowing a single dose of 150 mg of [14C] idelalisib, 78% and 14% of the radioactivity was excreted in feces and urine, respectively. GS-563117, idelalisib's major metabolite, accounted for 49% of the radioactivity in the urine and 44% in the feces.
Half lifeThe terminal elimination half-life is 8.2 hours.
Clearance

14.9 L/hr

ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal AbsorptionNot AvailableNot Available
Blood Brain BarrierNot AvailableNot Available
Caco-2 permeableNot AvailableNot Available
P-glycoprotein substrateNot AvailableNot Available
P-glycoprotein inhibitor INot AvailableNot Available
P-glycoprotein inhibitor IINot AvailableNot Available
Renal organic cation transporterNot AvailableNot Available
CYP450 2C9 substrateNot AvailableNot Available
CYP450 2D6 substrateNot AvailableNot Available
CYP450 3A4 substrateNot AvailableNot Available
CYP450 1A2 substrateNot AvailableNot Available
CYP450 2C9 inhibitorNot AvailableNot Available
CYP450 2D6 inhibitorNot AvailableNot Available
CYP450 2C19 inhibitorNot AvailableNot Available
CYP450 3A4 inhibitorNot AvailableNot Available
CYP450 inhibitory promiscuityNot AvailableNot Available
Ames testNot AvailableNot Available
CarcinogenicityNot AvailableNot Available
BiodegradationNot AvailableNot Available
Rat acute toxicityNot AvailableNot applicable
hERG inhibition (predictor I)Not AvailableNot Available
hERG inhibition (predictor II)Not AvailableNot Available
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
Film-coated tabletOral use100 mg
Film-coated tabletOral use150 mg
Tabletoral100 mg
Tabletoral150 mg
Tablet, film coatedoral100 mg/1
Tablet, film coatedoral150 mg/1
PricesNot Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6800620 No2001-04-242021-04-24Us
US6949535 No2001-04-242021-04-24Us
US8138195 No2001-04-242021-04-24Us
US8492389 No2001-04-242021-04-24Us
US8637533 No2001-04-242021-04-24Us
US8865730 No2013-03-052033-03-05Us
US8980901 No2005-05-122025-05-12Us
US9149477 No2005-05-122025-05-12Us
USRE44599 No2005-07-212025-07-21Us
USRE44638 No2005-08-052025-08-05Us
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.0255 mg/mLALOGPS
logP3.03ALOGPS
logP3.36ChemAxon
logS-4.2ALOGPS
pKa (Strongest Acidic)9.86ChemAxon
pKa (Strongest Basic)4.27ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area99.16 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity116.83 m3·mol-1ChemAxon
Polarizability41.41 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis ReferenceNot Available
General References
  1. Jin F, Robeson M, Zhou H, Moyer C, Wilbert S, Murray B, Ramanathan S: Clinical drug interaction profile of idelalisib in healthy subjects. J Clin Pharmacol. 2015 Aug;55(8):909-19. doi: 10.1002/jcph.495. Epub 2015 May 6. [PubMed:25760671 ]
  2. Fiorcari S, Brown WS, McIntyre BW, Estrov Z, Maffei R, O'Brien S, Sivina M, Hoellenriegel J, Wierda WG, Keating MJ, Ding W, Kay NE, Lannutti BJ, Marasca R, Burger JA: The PI3-kinase delta inhibitor idelalisib (GS-1101) targets integrin-mediated adhesion of chronic lymphocytic leukemia (CLL) cell to endothelial and marrow stromal cells. PLoS One. 2013 Dec 23;8(12):e83830. doi: 10.1371/journal.pone.0083830. eCollection 2013. [PubMed:24376763 ]
  3. Flinn IW, Kahl BS, Leonard JP, Furman RR, Brown JR, Byrd JC, Wagner-Johnston ND, Coutre SE, Benson DM, Peterman S, Cho Y, Webb HK, Johnson DM, Yu AS, Ulrich RG, Godfrey WR, Miller LL, Spurgeon SE: Idelalisib, a selective inhibitor of phosphatidylinositol 3-kinase-delta, as therapy for previously treated indolent non-Hodgkin lymphoma. Blood. 2014 May 29;123(22):3406-13. doi: 10.1182/blood-2013-11-538546. Epub 2014 Mar 10. [PubMed:24615776 ]
  4. Brown JR, Byrd JC, Coutre SE, Benson DM, Flinn IW, Wagner-Johnston ND, Spurgeon SE, Kahl BS, Bello C, Webb HK, Johnson DM, Peterman S, Li D, Jahn TM, Lannutti BJ, Ulrich RG, Yu AS, Miller LL, Furman RR: Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110delta, for relapsed/refractory chronic lymphocytic leukemia. Blood. 2014 May 29;123(22):3390-7. doi: 10.1182/blood-2013-11-535047. Epub 2014 Mar 10. [PubMed:24615777 ]
External Links
ATC CodesL01XX47
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelDownload (496 KB)
MSDSNot Available
Interactions
Drug Interactions
Drug
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be increased when it is combined with Idelalisib.
AbirateroneThe serum concentration of Abiraterone can be increased when it is combined with Idelalisib.
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Idelalisib.
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Idelalisib.
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Idelalisib.
AcetyldigitoxinAcetyldigitoxin may decrease the cardiotoxic activities of Idelalisib.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Idelalisib.
AdinazolamThe serum concentration of Adinazolam can be increased when it is combined with Idelalisib.
AfatinibThe serum concentration of Idelalisib can be increased when it is combined with Afatinib.
AlbendazoleThe serum concentration of Albendazole can be increased when it is combined with Idelalisib.
AlclometasoneThe serum concentration of Alclometasone can be increased when it is combined with Idelalisib.
AldosteroneThe serum concentration of Idelalisib can be decreased when it is combined with Aldosterone.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Idelalisib.
AlectinibThe serum concentration of Idelalisib can be increased when it is combined with Alectinib.
AlfentanilThe serum concentration of Alfentanil can be increased when it is combined with Idelalisib.
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Idelalisib.
AliskirenThe serum concentration of Aliskiren can be increased when it is combined with Idelalisib.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Idelalisib.
AllylestrenolThe serum concentration of Allylestrenol can be increased when it is combined with Idelalisib.
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Idelalisib.
AlogliptinThe serum concentration of Alogliptin can be increased when it is combined with Idelalisib.
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Idelalisib.
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Idelalisib.
AmantadineThe serum concentration of Idelalisib can be increased when it is combined with Amantadine.
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Idelalisib.
AmbroxolThe serum concentration of Ambroxol can be increased when it is combined with Idelalisib.
AmcinonideThe serum concentration of Amcinonide can be increased when it is combined with Idelalisib.
Aminohippuric acidThe serum concentration of Idelalisib can be increased when it is combined with Aminohippuric acid.
AminophenazoneThe serum concentration of Aminophenazone can be increased when it is combined with Idelalisib.
AminophyllineThe serum concentration of Aminophylline can be increased when it is combined with Idelalisib.
AmiodaroneThe serum concentration of Amiodarone can be increased when it is combined with Idelalisib.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Idelalisib.
AmlodipineThe serum concentration of Amlodipine can be increased when it is combined with Idelalisib.
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Idelalisib.
AmprenavirThe serum concentration of Amprenavir can be increased when it is combined with Idelalisib.
AmprenavirThe serum concentration of Idelalisib can be decreased when it is combined with Amprenavir.
AmsacrineThe serum concentration of Idelalisib can be increased when it is combined with Amsacrine.
AntipyrineThe serum concentration of Antipyrine can be increased when it is combined with Idelalisib.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Idelalisib.
ApremilastThe serum concentration of Apremilast can be increased when it is combined with Idelalisib.
AprepitantThe serum concentration of Aprepitant can be increased when it is combined with Idelalisib.
ArgatrobanThe serum concentration of Argatroban can be increased when it is combined with Idelalisib.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Idelalisib.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Idelalisib.
ArtemetherThe serum concentration of Artemether can be increased when it is combined with Idelalisib.
AsenapineThe serum concentration of Asenapine can be increased when it is combined with Idelalisib.
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Idelalisib.
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Idelalisib.
AtenololThe serum concentration of Idelalisib can be increased when it is combined with Atenolol.
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Idelalisib.
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Idelalisib.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Idelalisib.
AzelastineThe serum concentration of Azelastine can be increased when it is combined with Idelalisib.
AzithromycinThe serum concentration of Azithromycin can be increased when it is combined with Idelalisib.
BanoxantroneThe serum concentration of Banoxantrone can be increased when it is combined with Idelalisib.
BarnidipineThe serum concentration of Barnidipine can be increased when it is combined with Idelalisib.
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be increased when it is combined with Idelalisib.
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Idelalisib.
BenzocaineThe serum concentration of Idelalisib can be increased when it is combined with Benzocaine.
BenzphetamineThe serum concentration of Benzphetamine can be increased when it is combined with Idelalisib.
Benzyl alcoholThe serum concentration of Benzyl alcohol can be increased when it is combined with Idelalisib.
BepridilThe serum concentration of Idelalisib can be increased when it is combined with Bepridil.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Idelalisib.
BevacizumabBevacizumab may increase the cardiotoxic activities of Idelalisib.
BexaroteneThe serum concentration of Bexarotene can be increased when it is combined with Idelalisib.
BezafibrateThe serum concentration of Bezafibrate can be increased when it is combined with Idelalisib.
BicalutamideThe serum concentration of Bicalutamide can be increased when it is combined with Idelalisib.
BiperidenThe serum concentration of Idelalisib can be increased when it is combined with Biperiden.
BisoprololThe serum concentration of Bisoprolol can be increased when it is combined with Idelalisib.
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Idelalisib.
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Idelalisib.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Idelalisib.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Idelalisib.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Idelalisib.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Idelalisib.
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Idelalisib.
BromazepamThe serum concentration of Bromazepam can be increased when it is combined with Idelalisib.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Idelalisib.
BrompheniramineThe serum concentration of Brompheniramine can be increased when it is combined with Idelalisib.
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Idelalisib.
BupivacaineThe serum concentration of Bupivacaine can be increased when it is combined with Idelalisib.
BuprenorphineThe serum concentration of Buprenorphine can be increased when it is combined with Idelalisib.
BupropionThe serum concentration of Bupropion can be increased when it is combined with Idelalisib.
BuspironeThe serum concentration of Buspirone can be increased when it is combined with Idelalisib.
BusulfanThe serum concentration of Busulfan can be increased when it is combined with Idelalisib.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Idelalisib.
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Idelalisib.
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Idelalisib.
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Idelalisib.
CalcitriolThe serum concentration of Calcitriol can be increased when it is combined with Idelalisib.
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Idelalisib.
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Idelalisib.
CandesartanThe serum concentration of Idelalisib can be increased when it is combined with Candesartan.
CaptoprilThe serum concentration of Idelalisib can be increased when it is combined with Captopril.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Idelalisib.
CarbamazepineThe serum concentration of Idelalisib can be decreased when it is combined with Carbamazepine.
CarbinoxamineThe serum concentration of Carbinoxamine can be increased when it is combined with Idelalisib.
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Idelalisib.
CariprazineThe serum concentration of Cariprazine can be increased when it is combined with Idelalisib.
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Idelalisib.
CaspofunginThe serum concentration of Idelalisib can be increased when it is combined with Caspofungin.
CelecoxibThe serum concentration of Celecoxib can be increased when it is combined with Idelalisib.
CeliprololThe serum concentration of Celiprolol can be increased when it is combined with Idelalisib.
CephalexinThe serum concentration of Cephalexin can be increased when it is combined with Idelalisib.
CeritinibThe serum concentration of Ceritinib can be increased when it is combined with Idelalisib.
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Idelalisib.
CevimelineThe serum concentration of Cevimeline can be increased when it is combined with Idelalisib.
Chenodeoxycholic acidThe serum concentration of Chenodeoxycholic acid can be increased when it is combined with Idelalisib.
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be increased when it is combined with Idelalisib.
ChloroquineThe serum concentration of Chloroquine can be increased when it is combined with Idelalisib.
ChlorphenamineThe serum concentration of Chlorphenamine can be increased when it is combined with Idelalisib.
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Idelalisib.
ChlorpropamideThe serum concentration of Idelalisib can be increased when it is combined with Chlorpropamide.
ChlorprothixeneThe serum concentration of Idelalisib can be increased when it is combined with Chlorprothixene.
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be increased when it is combined with Idelalisib.
CholecalciferolThe serum concentration of Cholecalciferol can be increased when it is combined with Idelalisib.
CholesterolThe serum concentration of Idelalisib can be increased when it is combined with Cholesterol.
Cholic AcidThe serum concentration of Idelalisib can be decreased when it is combined with Cholic Acid.
CiclesonideThe serum concentration of Ciclesonide can be increased when it is combined with Idelalisib.
CilazaprilThe serum concentration of Idelalisib can be increased when it is combined with Cilazapril.
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Idelalisib.
CimetidineThe serum concentration of Idelalisib can be decreased when it is combined with Cimetidine.
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Idelalisib.
CinacalcetThe serum concentration of Cinacalcet can be increased when it is combined with Idelalisib.
CiprofloxacinThe serum concentration of Idelalisib can be increased when it is combined with Ciprofloxacin.
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Idelalisib.
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Idelalisib.
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Idelalisib.
ClarithromycinThe serum concentration of Clarithromycin can be increased when it is combined with Idelalisib.
ClindamycinThe serum concentration of Clindamycin can be increased when it is combined with Idelalisib.
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Idelalisib.
Clobetasol propionateThe serum concentration of Clobetasol propionate can be increased when it is combined with Idelalisib.
ClocortoloneThe serum concentration of Clocortolone can be increased when it is combined with Idelalisib.
ClofazimineThe serum concentration of Clofazimine can be increased when it is combined with Idelalisib.
ClofibrateThe serum concentration of Clofibrate can be increased when it is combined with Idelalisib.
clomethiazoleThe serum concentration of clomethiazole can be increased when it is combined with Idelalisib.
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Idelalisib.
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Idelalisib.
ClonazepamThe serum concentration of Clonazepam can be increased when it is combined with Idelalisib.
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Idelalisib.
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Idelalisib.
ClorazepateThe serum concentration of Clorazepate can be increased when it is combined with Idelalisib.
ClotiazepamThe serum concentration of Clotiazepam can be increased when it is combined with Idelalisib.
ClotrimazoleThe serum concentration of Idelalisib can be decreased when it is combined with Clotrimazole.
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Idelalisib.
CobicistatThe serum concentration of Idelalisib can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Idelalisib.
CocaineThe serum concentration of Cocaine can be increased when it is combined with Idelalisib.
CodeineThe serum concentration of Codeine can be increased when it is combined with Idelalisib.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Idelalisib.
ColforsinThe serum concentration of Idelalisib can be increased when it is combined with Colforsin.
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Idelalisib.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Idelalisib.
Cortisone acetateThe serum concentration of Cortisone acetate can be increased when it is combined with Idelalisib.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Idelalisib.
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Idelalisib.
CyclophosphamideThe serum concentration of Cyclophosphamide can be increased when it is combined with Idelalisib.
CyclophosphamideCyclophosphamide may increase the cardiotoxic activities of Idelalisib.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Idelalisib.
CyclosporineThe serum concentration of Idelalisib can be decreased when it is combined with Cyclosporine.
CytarabineThe serum concentration of Cytarabine can be increased when it is combined with Idelalisib.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Idelalisib.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Idelalisib.
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Idelalisib.
DactinomycinThe serum concentration of Idelalisib can be increased when it is combined with Dactinomycin.
DantroleneThe serum concentration of Dantrolene can be increased when it is combined with Idelalisib.
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Idelalisib.
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Idelalisib.
DapsoneThe serum concentration of Dapsone can be increased when it is combined with Idelalisib.
DarifenacinThe serum concentration of Darifenacin can be increased when it is combined with Idelalisib.
DarunavirThe serum concentration of Darunavir can be increased when it is combined with Idelalisib.
DasabuvirThe serum concentration of Dasabuvir can be increased when it is combined with Idelalisib.
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Idelalisib.
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Idelalisib.
DaunorubicinThe serum concentration of Idelalisib can be decreased when it is combined with Daunorubicin.
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Idelalisib.
DehydroepiandrosteroneThe serum concentration of Dehydroepiandrosterone can be increased when it is combined with Idelalisib.
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be increased when it is combined with Idelalisib.
DelavirdineThe serum concentration of Delavirdine can be increased when it is combined with Idelalisib.
DenosumabThe risk or severity of adverse effects can be increased when Denosumab is combined with Idelalisib.
DesipramineThe serum concentration of Idelalisib can be increased when it is combined with Desipramine.
DeslanosideDeslanoside may decrease the cardiotoxic activities of Idelalisib.
DesloratadineThe serum concentration of Idelalisib can be increased when it is combined with Desloratadine.
DesoximetasoneThe serum concentration of Desoximetasone can be increased when it is combined with Idelalisib.
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be increased when it is combined with Idelalisib.
DesvenlafaxineThe serum concentration of Desvenlafaxine can be increased when it is combined with Idelalisib.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Idelalisib.
DexamethasoneThe serum concentration of Idelalisib can be decreased when it is combined with Dexamethasone.
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Idelalisib.
DextromethorphanThe serum concentration of Dextromethorphan can be increased when it is combined with Idelalisib.
DextropropoxypheneThe serum concentration of Dextropropoxyphene can be increased when it is combined with Idelalisib.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Idelalisib.
DiclofenacThe serum concentration of Diclofenac can be increased when it is combined with Idelalisib.
DienogestThe serum concentration of Dienogest can be increased when it is combined with Idelalisib.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Idelalisib.
DiflorasoneThe serum concentration of Diflorasone can be increased when it is combined with Idelalisib.
DifluocortoloneThe serum concentration of Difluocortolone can be increased when it is combined with Idelalisib.
DifluprednateThe serum concentration of Difluprednate can be increased when it is combined with Idelalisib.
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Idelalisib.
DigitoxinDigitoxin may decrease the cardiotoxic activities of Idelalisib.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Idelalisib.
DigoxinDigoxin may decrease the cardiotoxic activities of Idelalisib.
DihydrocodeineThe serum concentration of Dihydrocodeine can be increased when it is combined with Idelalisib.
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Idelalisib.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Idelalisib.
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Idelalisib.
DipyridamoleThe serum concentration of Idelalisib can be increased when it is combined with Dipyridamole.
DisopyramideThe serum concentration of Disopyramide can be increased when it is combined with Idelalisib.
DisulfiramThe serum concentration of Disulfiram can be increased when it is combined with Idelalisib.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Idelalisib.
DocetaxelThe risk or severity of adverse effects can be increased when Docetaxel is combined with Idelalisib.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Idelalisib.
DolasetronThe serum concentration of Dolasetron can be increased when it is combined with Idelalisib.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Idelalisib.
DonepezilThe serum concentration of Donepezil can be increased when it is combined with Idelalisib.
DorzolamideThe serum concentration of Dorzolamide can be increased when it is combined with Idelalisib.
DoxazosinThe serum concentration of Idelalisib can be increased when it is combined with Doxazosin.
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Idelalisib.
DoxorubicinThe serum concentration of Idelalisib can be decreased when it is combined with Doxorubicin.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Idelalisib.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Idelalisib.
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Idelalisib.
DrospirenoneThe serum concentration of Drospirenone can be increased when it is combined with Idelalisib.
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Idelalisib.
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Idelalisib.
EfavirenzThe serum concentration of Efavirenz can be increased when it is combined with Idelalisib.
ElbasvirThe serum concentration of Idelalisib can be increased when it is combined with Elbasvir.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Idelalisib.
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Idelalisib.
EltrombopagThe serum concentration of Idelalisib can be increased when it is combined with Eltrombopag.
ElvitegravirThe serum concentration of Elvitegravir can be increased when it is combined with Idelalisib.
EnalaprilThe serum concentration of Enalapril can be increased when it is combined with Idelalisib.
EnzalutamideThe serum concentration of Enzalutamide can be increased when it is combined with Idelalisib.
EnzalutamideThe serum concentration of Idelalisib can be decreased when it is combined with Enzalutamide.
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Idelalisib.
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Idelalisib.
EquileninThe serum concentration of Equilenin can be increased when it is combined with Idelalisib.
EquilinThe serum concentration of Equilin can be increased when it is combined with Idelalisib.
ErgocalciferolThe serum concentration of Ergocalciferol can be increased when it is combined with Idelalisib.
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Idelalisib.
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Idelalisib.
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Idelalisib.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Idelalisib.
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Idelalisib.
ErythromycinThe serum concentration of Idelalisib can be decreased when it is combined with Erythromycin.
EscitalopramThe serum concentration of Escitalopram can be increased when it is combined with Idelalisib.
EsomeprazoleThe serum concentration of Esomeprazole can be increased when it is combined with Idelalisib.
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Idelalisib.
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Idelalisib.
Estradiol valerate/DienogestThe serum concentration of Estradiol valerate/Dienogest can be increased when it is combined with Idelalisib.
EstramustineThe serum concentration of Estramustine can be increased when it is combined with Idelalisib.
EstriolThe serum concentration of Idelalisib can be decreased when it is combined with Estriol.
EstriolThe serum concentration of Estriol can be increased when it is combined with Idelalisib.
EstroneThe serum concentration of Estrone can be increased when it is combined with Idelalisib.
EstroneThe serum concentration of Idelalisib can be decreased when it is combined with Estrone.
Estrone sulfateThe serum concentration of Estrone sulfate can be increased when it is combined with Idelalisib.
EszopicloneThe serum concentration of Eszopiclone can be increased when it is combined with Idelalisib.
EthanolThe serum concentration of Ethanol can be increased when it is combined with Idelalisib.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Idelalisib.
EthosuximideThe serum concentration of Ethosuximide can be increased when it is combined with Idelalisib.
EthylmorphineThe serum concentration of Ethylmorphine can be increased when it is combined with Idelalisib.
EtizolamThe serum concentration of Etizolam can be increased when it is combined with Idelalisib.
EtonogestrelThe serum concentration of Etonogestrel can be increased when it is combined with Idelalisib.
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Idelalisib.
EtoricoxibThe serum concentration of Etoricoxib can be increased when it is combined with Idelalisib.
EtravirineThe serum concentration of Etravirine can be increased when it is combined with Idelalisib.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Idelalisib.
ExemestaneThe serum concentration of Exemestane can be increased when it is combined with Idelalisib.
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Idelalisib.
FamciclovirThe serum concentration of Famciclovir can be increased when it is combined with Idelalisib.
FelbamateThe serum concentration of Felbamate can be increased when it is combined with Idelalisib.
FelodipineThe serum concentration of Felodipine can be increased when it is combined with Idelalisib.
FenofibrateThe serum concentration of Fenofibrate can be increased when it is combined with Idelalisib.
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Idelalisib.
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Idelalisib.
FexofenadineThe serum concentration of Idelalisib can be increased when it is combined with Fexofenadine.
FidaxomicinThe serum concentration of Idelalisib can be increased when it is combined with Fidaxomicin.
FinasterideThe serum concentration of Finasteride can be increased when it is combined with Idelalisib.
FingolimodThe serum concentration of Fingolimod can be increased when it is combined with Idelalisib.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Idelalisib.
FluconazoleThe serum concentration of Idelalisib can be increased when it is combined with Fluconazole.
FludrocortisoneThe serum concentration of Fludrocortisone can be increased when it is combined with Idelalisib.
FlumethasoneThe serum concentration of Flumethasone can be increased when it is combined with Idelalisib.
FlunisolideThe serum concentration of Flunisolide can be increased when it is combined with Idelalisib.
FlunitrazepamThe serum concentration of Flunitrazepam can be increased when it is combined with Idelalisib.
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be increased when it is combined with Idelalisib.
FluocinonideThe serum concentration of Fluocinonide can be increased when it is combined with Idelalisib.
FluocortoloneThe serum concentration of Fluocortolone can be increased when it is combined with Idelalisib.
FluorometholoneThe serum concentration of Fluorometholone can be increased when it is combined with Idelalisib.
FluoxetineThe serum concentration of Fluoxetine can be increased when it is combined with Idelalisib.
FlupentixolThe serum concentration of Idelalisib can be increased when it is combined with Flupentixol.
FluphenazineThe serum concentration of Idelalisib can be increased when it is combined with Fluphenazine.
FluprednideneThe serum concentration of Fluprednidene can be increased when it is combined with Idelalisib.
FluprednisoloneThe serum concentration of Fluprednisolone can be increased when it is combined with Idelalisib.
FlurandrenolideThe serum concentration of Flurandrenolide can be increased when it is combined with Idelalisib.
FlurazepamThe serum concentration of Flurazepam can be increased when it is combined with Idelalisib.
FlutamideThe serum concentration of Flutamide can be increased when it is combined with Idelalisib.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Idelalisib.
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Idelalisib.
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Idelalisib.
FluvoxamineThe serum concentration of Idelalisib can be increased when it is combined with Fluvoxamine.
FosamprenavirThe serum concentration of Fosamprenavir can be increased when it is combined with Idelalisib.
FosphenytoinThe serum concentration of Idelalisib can be decreased when it is combined with Fosphenytoin.
FulvestrantThe serum concentration of Fulvestrant can be increased when it is combined with Idelalisib.
GalantamineThe serum concentration of Galantamine can be increased when it is combined with Idelalisib.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Idelalisib.
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Idelalisib.
GemfibrozilThe serum concentration of Gemfibrozil can be increased when it is combined with Idelalisib.
GenisteinThe serum concentration of Idelalisib can be increased when it is combined with Genistein.
GlipizideThe serum concentration of Glipizide can be increased when it is combined with Idelalisib.
GlyburideThe serum concentration of Glyburide can be increased when it is combined with Idelalisib.
GlycerolThe serum concentration of Idelalisib can be increased when it is combined with Glycerol.
Gramicidin DThe serum concentration of Idelalisib can be increased when it is combined with Gramicidin D.
GranisetronThe serum concentration of Granisetron can be increased when it is combined with Idelalisib.
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Idelalisib.
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Idelalisib.
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Idelalisib.
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Idelalisib.
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Idelalisib.
HalothaneThe serum concentration of Halothane can be increased when it is combined with Idelalisib.
HexobarbitalThe serum concentration of Hexobarbital can be increased when it is combined with Idelalisib.
Histamine PhosphateThe serum concentration of Histamine Phosphate can be increased when it is combined with Idelalisib.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Idelalisib.
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Idelalisib.
HydromorphoneThe serum concentration of Hydromorphone can be increased when it is combined with Idelalisib.
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be increased when it is combined with Idelalisib.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Idelalisib.
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Idelalisib.
IfosfamideThe serum concentration of Ifosfamide can be increased when it is combined with Idelalisib.
IloperidoneThe serum concentration of Iloperidone can be increased when it is combined with Idelalisib.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Idelalisib.
ImidafenacinThe serum concentration of Imidafenacin can be increased when it is combined with Idelalisib.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Idelalisib.
ImiquimodThe serum concentration of Imiquimod can be increased when it is combined with Idelalisib.
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Idelalisib.
IndapamideThe serum concentration of Indapamide can be increased when it is combined with Idelalisib.
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Idelalisib.
IndomethacinThe serum concentration of Idelalisib can be increased when it is combined with Indomethacin.
Ipratropium bromideThe serum concentration of Ipratropium bromide can be increased when it is combined with Idelalisib.
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Idelalisib.
IsavuconazoniumThe serum concentration of Isavuconazonium can be increased when it is combined with Idelalisib.
Isosorbide DinitrateThe serum concentration of Isosorbide Dinitrate can be increased when it is combined with Idelalisib.
Isosorbide MononitrateThe serum concentration of Isosorbide Mononitrate can be increased when it is combined with Idelalisib.
IsradipineThe serum concentration of Isradipine can be increased when it is combined with Idelalisib.
ItraconazoleThe serum concentration of Itraconazole can be increased when it is combined with Idelalisib.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Idelalisib.
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Idelalisib.
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Idelalisib.
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Idelalisib.
IxazomibThe serum concentration of Ixazomib can be increased when it is combined with Idelalisib.
KetamineThe serum concentration of Ketamine can be increased when it is combined with Idelalisib.
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Idelalisib.
KetobemidoneThe serum concentration of Ketobemidone can be increased when it is combined with Idelalisib.
KetoconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Idelalisib.
LacosamideThe serum concentration of Lacosamide can be increased when it is combined with Idelalisib.
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Idelalisib.
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Idelalisib.
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Idelalisib.
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Idelalisib.
LaquinimodThe serum concentration of Laquinimod can be increased when it is combined with Idelalisib.
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Idelalisib.
LeflunomideThe risk or severity of adverse effects can be increased when Idelalisib is combined with Leflunomide.
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Idelalisib.
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Idelalisib.
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Idelalisib.
LetrozoleThe serum concentration of Letrozole can be increased when it is combined with Idelalisib.
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Idelalisib.
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Idelalisib.
LevocetirizineThe serum concentration of Levocetirizine can be increased when it is combined with Idelalisib.
LevofloxacinThe serum concentration of Idelalisib can be increased when it is combined with Levofloxacin.
Levomethadyl AcetateThe serum concentration of Levomethadyl Acetate can be increased when it is combined with Idelalisib.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Idelalisib.
LevonorgestrelThe serum concentration of Levonorgestrel can be increased when it is combined with Idelalisib.
LevothyroxineThe serum concentration of Levothyroxine can be increased when it is combined with Idelalisib.
LevothyroxineThe serum concentration of Idelalisib can be decreased when it is combined with Levothyroxine.
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Idelalisib.
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Idelalisib.
LiothyronineThe serum concentration of Idelalisib can be decreased when it is combined with Liothyronine.
LiotrixThe serum concentration of Idelalisib can be decreased when it is combined with Liotrix.
LisinoprilThe serum concentration of Idelalisib can be increased when it is combined with Lisinopril.
LisurideThe serum concentration of Lisuride can be increased when it is combined with Idelalisib.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Idelalisib.
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Idelalisib.
LopinavirThe serum concentration of Lopinavir can be increased when it is combined with Idelalisib.
LoratadineThe serum concentration of Loratadine can be increased when it is combined with Idelalisib.
LorcaserinThe serum concentration of Lorcaserin can be increased when it is combined with Idelalisib.
LosartanThe serum concentration of Losartan can be increased when it is combined with Idelalisib.
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Idelalisib.
LumacaftorThe serum concentration of Idelalisib can be decreased when it is combined with Lumacaftor.
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Idelalisib.
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Idelalisib.
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Idelalisib.
MannitolThe serum concentration of Mannitol can be increased when it is combined with Idelalisib.
MaprotilineThe serum concentration of Idelalisib can be increased when it is combined with Maprotiline.
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Idelalisib.
MebendazoleThe serum concentration of Mebendazole can be increased when it is combined with Idelalisib.
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Idelalisib.
MedrysoneThe serum concentration of Medrysone can be increased when it is combined with Idelalisib.
MefloquineThe serum concentration of Mefloquine can be increased when it is combined with Idelalisib.
Megestrol acetateThe serum concentration of Idelalisib can be increased when it is combined with Megestrol acetate.
MelengestrolThe serum concentration of Melengestrol can be increased when it is combined with Idelalisib.
MeloxicamThe serum concentration of Meloxicam can be increased when it is combined with Idelalisib.
MeprobamateThe serum concentration of Idelalisib can be increased when it is combined with Meprobamate.
MethadoneThe serum concentration of Methadone can be increased when it is combined with Idelalisib.
MethaqualoneThe serum concentration of Methaqualone can be increased when it is combined with Idelalisib.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Idelalisib.
MethoxsalenThe serum concentration of Methoxsalen can be increased when it is combined with Idelalisib.
MethoxyfluraneThe serum concentration of Methoxyflurane can be increased when it is combined with Idelalisib.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Idelalisib.
MethyltestosteroneThe serum concentration of Methyltestosterone can be increased when it is combined with Idelalisib.
MetoprololThe serum concentration of Idelalisib can be increased when it is combined with Metoprolol.
MetronidazoleThe serum concentration of Metronidazole can be increased when it is combined with Idelalisib.
MexiletineThe serum concentration of Mexiletine can be increased when it is combined with Idelalisib.
MianserinThe serum concentration of Mianserin can be increased when it is combined with Idelalisib.
MibefradilThe serum concentration of Mibefradil can be increased when it is combined with Idelalisib.
MiconazoleThe serum concentration of Miconazole can be increased when it is combined with Idelalisib.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Idelalisib.
MidazolamThe serum concentration of Idelalisib can be decreased when it is combined with Midazolam.
MifepristoneThe serum concentration of Mifepristone can be increased when it is combined with Idelalisib.
MifepristoneThe serum concentration of Idelalisib can be decreased when it is combined with Mifepristone.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Idelalisib.
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Idelalisib.
MitomycinThe serum concentration of Idelalisib can be increased when it is combined with Mitomycin.
MitotaneThe serum concentration of Idelalisib can be decreased when it is combined with Mitotane.
MitoxantroneThe serum concentration of Idelalisib can be decreased when it is combined with Mitoxantrone.
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Idelalisib.
ModafinilThe serum concentration of Modafinil can be increased when it is combined with Idelalisib.
MometasoneThe serum concentration of Mometasone can be increased when it is combined with Idelalisib.
MontelukastThe serum concentration of Montelukast can be increased when it is combined with Idelalisib.
MorphineThe serum concentration of Morphine can be increased when it is combined with Idelalisib.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Idelalisib.
NadololThe serum concentration of Nadolol can be increased when it is combined with Idelalisib.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Idelalisib.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Idelalisib.
NaltrexoneThe serum concentration of Idelalisib can be increased when it is combined with Naltrexone.
NaringeninThe serum concentration of Idelalisib can be increased when it is combined with Naringenin.
NatalizumabThe risk or severity of adverse effects can be increased when Idelalisib is combined with Natalizumab.
NateglinideThe serum concentration of Nateglinide can be increased when it is combined with Idelalisib.
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Idelalisib.
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Idelalisib.
NeostigmineThe serum concentration of Idelalisib can be increased when it is combined with Neostigmine.
NevirapineThe serum concentration of Nevirapine can be increased when it is combined with Idelalisib.
NevirapineThe serum concentration of Idelalisib can be decreased when it is combined with Nevirapine.
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Idelalisib.
NicotineThe serum concentration of Nicotine can be increased when it is combined with Idelalisib.
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Idelalisib.
NifedipineThe serum concentration of Idelalisib can be decreased when it is combined with Nifedipine.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Idelalisib.
NilvadipineThe serum concentration of Nilvadipine can be increased when it is combined with Idelalisib.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Idelalisib.
NintedanibThe serum concentration of Nintedanib can be decreased when it is combined with Idelalisib.
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Idelalisib.
NitrazepamThe serum concentration of Nitrazepam can be increased when it is combined with Idelalisib.
NitrendipineThe serum concentration of Nitrendipine can be increased when it is combined with Idelalisib.
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Idelalisib.
NorethisteroneThe serum concentration of Norethisterone can be increased when it is combined with Idelalisib.
NorethisteroneThe serum concentration of Idelalisib can be decreased when it is combined with Norethisterone.
NorgestrelThe serum concentration of Norgestrel can be increased when it is combined with Idelalisib.
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Idelalisib.
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Idelalisib.
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Idelalisib.
OlopatadineThe serum concentration of Olopatadine can be increased when it is combined with Idelalisib.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Idelalisib.
OmeprazoleThe serum concentration of Omeprazole can be increased when it is combined with Idelalisib.
OndansetronThe serum concentration of Ondansetron can be increased when it is combined with Idelalisib.
OrphenadrineThe serum concentration of Orphenadrine can be increased when it is combined with Idelalisib.
OsimertinibThe serum concentration of Osimertinib can be increased when it is combined with Idelalisib.
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Idelalisib.
OuabainOuabain may decrease the cardiotoxic activities of Idelalisib.
OxazepamThe serum concentration of Oxazepam can be increased when it is combined with Idelalisib.
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Idelalisib.
OxycodoneThe serum concentration of Oxycodone can be increased when it is combined with Idelalisib.
OxymorphoneThe serum concentration of Oxymorphone can be increased when it is combined with Idelalisib.
P-NitrophenolThe serum concentration of Idelalisib can be increased when it is combined with P-Nitrophenol.
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Idelalisib.
PalbociclibThe serum concentration of Palbociclib can be increased when it is combined with Idelalisib.
Palmitic AcidThe serum concentration of Idelalisib can be increased when it is combined with Palmitic Acid.
PalonosetronThe serum concentration of Palonosetron can be increased when it is combined with Idelalisib.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Idelalisib.
PantoprazoleThe serum concentration of Pantoprazole can be increased when it is combined with Idelalisib.
ParamethadioneThe serum concentration of Paramethadione can be increased when it is combined with Idelalisib.
ParamethasoneThe serum concentration of Paramethasone can be increased when it is combined with Idelalisib.
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Idelalisib.
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Idelalisib.
ParitaprevirThe serum concentration of Paritaprevir can be increased when it is combined with Idelalisib.
ParoxetineThe serum concentration of Idelalisib can be increased when it is combined with Paroxetine.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Idelalisib.
PentamidineThe serum concentration of Pentamidine can be increased when it is combined with Idelalisib.
PentobarbitalThe serum concentration of Idelalisib can be decreased when it is combined with Pentobarbital.
PerampanelThe serum concentration of Perampanel can be increased when it is combined with Idelalisib.
PergolideThe serum concentration of Pergolide can be increased when it is combined with Idelalisib.
PerhexilineThe serum concentration of Perhexiline can be increased when it is combined with Idelalisib.
PerindoprilThe serum concentration of Idelalisib can be increased when it is combined with Perindopril.
PermethrinThe serum concentration of Permethrin can be increased when it is combined with Idelalisib.
PerphenazineThe serum concentration of Perphenazine can be increased when it is combined with Idelalisib.
PethidineThe serum concentration of Pethidine can be increased when it is combined with Idelalisib.
PhenacetinThe serum concentration of Phenacetin can be increased when it is combined with Idelalisib.
PhenobarbitalThe serum concentration of Idelalisib can be decreased when it is combined with Phenobarbital.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Idelalisib.
PhenoxybenzamineThe serum concentration of Phenoxybenzamine can be increased when it is combined with Idelalisib.
PhenprocoumonThe serum concentration of Phenprocoumon can be increased when it is combined with Idelalisib.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Idelalisib.
PhenytoinThe serum concentration of Idelalisib can be decreased when it is combined with Phenytoin.
PilocarpineThe serum concentration of Pilocarpine can be increased when it is combined with Idelalisib.
PimecrolimusThe risk or severity of adverse effects can be increased when Pimecrolimus is combined with Idelalisib.
PimecrolimusThe serum concentration of Pimecrolimus can be increased when it is combined with Idelalisib.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Idelalisib.
PinacidilThe serum concentration of Pinacidil can be increased when it is combined with Idelalisib.
PioglitazoneThe serum concentration of Pioglitazone can be increased when it is combined with Idelalisib.
PipotiazineThe serum concentration of Pipotiazine can be increased when it is combined with Idelalisib.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Idelalisib.
Platelet Activating FactorThe serum concentration of Idelalisib can be decreased when it is combined with Platelet Activating Factor.
PodofiloxThe serum concentration of Podofilox can be increased when it is combined with Idelalisib.
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Idelalisib.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Idelalisib.
PosaconazoleThe serum concentration of Posaconazole can be increased when it is combined with Idelalisib.
PranlukastThe serum concentration of Pranlukast can be increased when it is combined with Idelalisib.
PrasugrelThe serum concentration of Prasugrel can be increased when it is combined with Idelalisib.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Idelalisib.
PrazepamThe serum concentration of Prazepam can be increased when it is combined with Idelalisib.
PraziquantelThe serum concentration of Praziquantel can be increased when it is combined with Idelalisib.
PrazosinThe serum concentration of Idelalisib can be increased when it is combined with Prazosin.
PrednicarbateThe serum concentration of Prednicarbate can be increased when it is combined with Idelalisib.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Idelalisib.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Idelalisib.
PregnenoloneThe serum concentration of Pregnenolone can be increased when it is combined with Idelalisib.
PrimaquineThe serum concentration of Primaquine can be increased when it is combined with Idelalisib.
PrimidoneThe serum concentration of Idelalisib can be decreased when it is combined with Primidone.
ProbenecidThe serum concentration of Idelalisib can be increased when it is combined with Probenecid.
ProchlorperazineThe serum concentration of Prochlorperazine can be increased when it is combined with Idelalisib.
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Idelalisib.
ProgesteroneThe serum concentration of Idelalisib can be decreased when it is combined with Progesterone.
ProguanilThe serum concentration of Proguanil can be increased when it is combined with Idelalisib.
PromazineThe serum concentration of Promazine can be increased when it is combined with Idelalisib.
PromethazineThe serum concentration of Idelalisib can be increased when it is combined with Promethazine.
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Idelalisib.
PropofolThe serum concentration of Propofol can be increased when it is combined with Idelalisib.
PropranololThe serum concentration of Propranolol can be increased when it is combined with Idelalisib.
ProtriptylineThe serum concentration of Idelalisib can be increased when it is combined with Protriptyline.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Idelalisib.
PyrazinamideThe serum concentration of Pyrazinamide can be increased when it is combined with Idelalisib.
QuazepamThe serum concentration of Quazepam can be increased when it is combined with Idelalisib.
QuercetinThe serum concentration of Idelalisib can be increased when it is combined with Quercetin.
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Idelalisib.
QuinacrineThe serum concentration of Quinacrine can be increased when it is combined with Idelalisib.
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Idelalisib.
QuinineThe serum concentration of Quinine can be increased when it is combined with Idelalisib.
RabeprazoleThe serum concentration of Rabeprazole can be increased when it is combined with Idelalisib.
Rabies vaccineThe risk or severity of adverse effects can be increased when Idelalisib is combined with Rabies vaccine.
RaloxifeneThe serum concentration of Raloxifene can be increased when it is combined with Idelalisib.
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Idelalisib.
RanitidineThe serum concentration of Idelalisib can be increased when it is combined with Ranitidine.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Idelalisib.
ReboxetineThe serum concentration of Reboxetine can be increased when it is combined with Idelalisib.
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Idelalisib.
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Idelalisib.
ReserpineThe serum concentration of Idelalisib can be decreased when it is combined with Reserpine.
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Idelalisib.
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Idelalisib.
RifabutinThe serum concentration of Rifabutin can be increased when it is combined with Idelalisib.
RifabutinThe serum concentration of Idelalisib can be decreased when it is combined with Rifabutin.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Idelalisib.
RifampicinThe serum concentration of Idelalisib can be decreased when it is combined with Rifampicin.
RifapentineThe serum concentration of Idelalisib can be decreased when it is combined with Rifapentine.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Idelalisib.
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Idelalisib.
RimexoloneThe serum concentration of Rimexolone can be increased when it is combined with Idelalisib.
RimonabantThe serum concentration of Rimonabant can be increased when it is combined with Idelalisib.
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Idelalisib.
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Idelalisib.
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Idelalisib.
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Idelalisib.
RofecoxibThe serum concentration of Rofecoxib can be increased when it is combined with Idelalisib.
RoflumilastRoflumilast may increase the immunosuppressive activities of Idelalisib.
RolapitantThe serum concentration of Rolapitant can be increased when it is combined with Idelalisib.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Idelalisib.
RopiniroleThe serum concentration of Ropinirole can be increased when it is combined with Idelalisib.
RopivacaineThe serum concentration of Ropivacaine can be increased when it is combined with Idelalisib.
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Idelalisib.
RotigotineThe serum concentration of Rotigotine can be increased when it is combined with Idelalisib.
RoxithromycinThe serum concentration of Roxithromycin can be increased when it is combined with Idelalisib.
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Idelalisib.
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Idelalisib.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Idelalisib.
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Idelalisib.
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Idelalisib.
ScopolamineThe serum concentration of Idelalisib can be increased when it is combined with Scopolamine.
SelegilineThe serum concentration of Selegiline can be increased when it is combined with Idelalisib.
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Idelalisib.
SeratrodastThe serum concentration of Seratrodast can be increased when it is combined with Idelalisib.
SertindoleThe serum concentration of Sertindole can be increased when it is combined with Idelalisib.
SertralineThe serum concentration of Sertraline can be increased when it is combined with Idelalisib.
SevofluraneThe serum concentration of Sevoflurane can be increased when it is combined with Idelalisib.
SibutramineThe serum concentration of Sibutramine can be increased when it is combined with Idelalisib.
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Idelalisib.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Idelalisib.
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Idelalisib.
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Idelalisib.
Sipuleucel-TThe therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Idelalisib.
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Idelalisib.
SirolimusThe serum concentration of Idelalisib can be decreased when it is combined with Sirolimus.
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Idelalisib.
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Idelalisib.
SolifenacinThe serum concentration of Solifenacin can be increased when it is combined with Idelalisib.
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Idelalisib.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Idelalisib.
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Idelalisib.
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Idelalisib.
SpiramycinThe serum concentration of Spiramycin can be increased when it is combined with Idelalisib.
SpironolactoneThe serum concentration of Idelalisib can be increased when it is combined with Spironolactone.
St. John's WortThe serum concentration of Idelalisib can be decreased when it is combined with St. John's Wort.
StaurosporineThe serum concentration of Idelalisib can be increased when it is combined with Staurosporine.
StreptozocinThe serum concentration of Idelalisib can be decreased when it is combined with Streptozocin.
SufentanilThe serum concentration of Sufentanil can be increased when it is combined with Idelalisib.
SulfadiazineThe serum concentration of Sulfadiazine can be increased when it is combined with Idelalisib.
SulfamethoxazoleThe serum concentration of Sulfamethoxazole can be increased when it is combined with Idelalisib.
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be increased when it is combined with Idelalisib.
SumatriptanThe serum concentration of Idelalisib can be increased when it is combined with Sumatriptan.
SunitinibThe serum concentration of Sunitinib can be increased when it is combined with Idelalisib.
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Idelalisib.
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be increased when it is combined with Idelalisib.
Synthetic Conjugated Estrogens, BThe serum concentration of Synthetic Conjugated Estrogens, B can be increased when it is combined with Idelalisib.
TacrineThe serum concentration of Idelalisib can be increased when it is combined with Tacrine.
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Idelalisib.
TacrolimusThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Idelalisib.
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Idelalisib.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Idelalisib.
TamoxifenThe serum concentration of Idelalisib can be decreased when it is combined with Tamoxifen.
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Idelalisib.
TasimelteonThe serum concentration of Tasimelteon can be increased when it is combined with Idelalisib.
TasosartanThe serum concentration of Tasosartan can be increased when it is combined with Idelalisib.
Taurochenodeoxycholic acidThe serum concentration of Taurochenodeoxycholic acid can be increased when it is combined with Idelalisib.
Taurocholic AcidThe serum concentration of Idelalisib can be increased when it is combined with Taurocholic Acid.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Idelalisib.
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Idelalisib.
TelithromycinThe serum concentration of Telithromycin can be increased when it is combined with Idelalisib.
TelmisartanThe serum concentration of Idelalisib can be increased when it is combined with Telmisartan.
TemazepamThe serum concentration of Temazepam can be increased when it is combined with Idelalisib.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Idelalisib.
TeniposideThe serum concentration of Teniposide can be increased when it is combined with Idelalisib.
TerazosinThe serum concentration of Idelalisib can be increased when it is combined with Terazosin.
TerbinafineThe serum concentration of Terbinafine can be increased when it is combined with Idelalisib.
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Idelalisib.
TeriflunomideThe serum concentration of Idelalisib can be increased when it is combined with Teriflunomide.
TesmilifeneThe serum concentration of Tesmilifene can be increased when it is combined with Idelalisib.
TesmilifeneThe serum concentration of Idelalisib can be decreased when it is combined with Tesmilifene.
TestosteroneThe serum concentration of Testosterone can be increased when it is combined with Idelalisib.
TetracyclineThe serum concentration of Tetracycline can be increased when it is combined with Idelalisib.
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Idelalisib.
ThiotepaThe serum concentration of Thiotepa can be increased when it is combined with Idelalisib.
TiagabineThe serum concentration of Tiagabine can be increased when it is combined with Idelalisib.
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Idelalisib.
TiclopidineThe serum concentration of Ticlopidine can be increased when it is combined with Idelalisib.
TimololThe serum concentration of Timolol can be increased when it is combined with Idelalisib.
TinidazoleThe serum concentration of Tinidazole can be increased when it is combined with Idelalisib.
TiotropiumThe serum concentration of Tiotropium can be increased when it is combined with Idelalisib.
TipranavirThe serum concentration of Tipranavir can be increased when it is combined with Idelalisib.
TixocortolThe serum concentration of Tixocortol can be increased when it is combined with Idelalisib.
TofacitinibIdelalisib may increase the immunosuppressive activities of Tofacitinib.
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Idelalisib.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Idelalisib.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Idelalisib.
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Idelalisib.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Idelalisib.
TramadolThe serum concentration of Tramadol can be increased when it is combined with Idelalisib.
TrastuzumabTrastuzumab may increase the neutropenic activities of Idelalisib.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Idelalisib.
TrazodoneThe serum concentration of Trazodone can be increased when it is combined with Idelalisib.
TrazodoneThe serum concentration of Idelalisib can be decreased when it is combined with Trazodone.
TretinoinThe serum concentration of Tretinoin can be increased when it is combined with Idelalisib.
TriamcinoloneThe serum concentration of Triamcinolone can be increased when it is combined with Idelalisib.
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Idelalisib.
TrifluoperazineThe serum concentration of Idelalisib can be increased when it is combined with Trifluoperazine.
TriflupromazineThe serum concentration of Idelalisib can be increased when it is combined with Triflupromazine.
TrimethadioneThe serum concentration of Trimethadione can be increased when it is combined with Idelalisib.
TrimethoprimThe serum concentration of Trimethoprim can be increased when it is combined with Idelalisib.
TrimethoprimThe serum concentration of Idelalisib can be decreased when it is combined with Trimethoprim.
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Idelalisib.
TroglitazoneThe serum concentration of Troglitazone can be increased when it is combined with Idelalisib.
TroleandomycinThe serum concentration of Troleandomycin can be increased when it is combined with Idelalisib.
UdenafilThe serum concentration of Udenafil can be increased when it is combined with Idelalisib.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Idelalisib.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Idelalisib.
ValdecoxibThe serum concentration of Valdecoxib can be increased when it is combined with Idelalisib.
VandetanibThe serum concentration of Vandetanib can be increased when it is combined with Idelalisib.
VanoxerineThe serum concentration of Vanoxerine can be increased when it is combined with Idelalisib.
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Idelalisib.
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Idelalisib.
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Idelalisib.
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Idelalisib.
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Idelalisib.
VerapamilThe serum concentration of Idelalisib can be decreased when it is combined with Verapamil.
VicrivirocThe serum concentration of Vicriviroc can be increased when it is combined with Idelalisib.
VilanterolThe serum concentration of Vilanterol can be increased when it is combined with Idelalisib.
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Idelalisib.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Idelalisib.
VinblastineThe serum concentration of Idelalisib can be decreased when it is combined with Vinblastine.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Idelalisib.
VincristineThe serum concentration of Idelalisib can be decreased when it is combined with Vincristine.
VindesineThe serum concentration of Vindesine can be increased when it is combined with Idelalisib.
VinorelbineThe serum concentration of Vinorelbine can be increased when it is combined with Idelalisib.
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Idelalisib.
VorapaxarThe serum concentration of Vorapaxar can be increased when it is combined with Idelalisib.
VoriconazoleThe serum concentration of Voriconazole can be increased when it is combined with Idelalisib.
VortioxetineThe serum concentration of Vortioxetine can be increased when it is combined with Idelalisib.
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Idelalisib.
YohimbineThe serum concentration of Yohimbine can be increased when it is combined with Idelalisib.
ZafirlukastThe serum concentration of Zafirlukast can be increased when it is combined with Idelalisib.
ZalcitabineThe serum concentration of Zalcitabine can be increased when it is combined with Idelalisib.
ZaleplonThe serum concentration of Zaleplon can be increased when it is combined with Idelalisib.
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Idelalisib.
ZileutonThe serum concentration of Zileuton can be increased when it is combined with Idelalisib.
ZimelidineThe serum concentration of Idelalisib can be increased when it is combined with Zimelidine.
ZiprasidoneThe serum concentration of Ziprasidone can be increased when it is combined with Idelalisib.
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Idelalisib.
ZomepiracThe serum concentration of Zomepirac can be increased when it is combined with Idelalisib.
ZonisamideThe serum concentration of Zonisamide can be increased when it is combined with Idelalisib.
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Idelalisib.
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Idelalisib.
Food InteractionsNot Available

Targets

1. Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (P110δ)
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
Inhibitor

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
no
Actions
substrate
General Function:
Xanthine dehydrogenase activity
Specific Function:
Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and N-methylphthalazinium, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyz...
Gene Name:
AOX1
Uniprot ID:
Q06278
Molecular Weight:
147916.735 Da
2. Cytochrome p450 3A subfamily
Kind
Protein group
Organism
Human
Pharmacological action
no
Actions
substrateinhibitor
3. UDP-glucuronosyltransferase 1A4
Kind
Protein
Organism
Human
Pharmacological action
no
Actions
substrate
4. UDP-glucuronosyltransferase 1A1
Kind
Protein
Organism
Human
Pharmacological action
no
Actions
inhibitor
Kind
Protein
Organism
Human
Pharmacological action
no
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
Kind
Protein
Organism
Human
Pharmacological action
no
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
Kind
Protein
Organism
Human
Pharmacological action
no
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
Kind
Protein
Organism
Human
Pharmacological action
no
Actions
inducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da

Transporters

Kind
Protein
Organism
Human
Pharmacological action
no
Actions
substrate
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from t...
Gene Name:
ABCG2
Uniprot ID:
Q9UNQ0
Molecular Weight:
72313.47 Da
Kind
Protein
Organism
Human
Pharmacological action
no
Actions
substrateinhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
Kind
Protein
Organism
Human
Pharmacological action
no
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B1
Uniprot ID:
Q9Y6L6
Molecular Weight:
76447.99 Da
Kind
Protein
Organism
Human
Pharmacological action
no
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B3
Uniprot ID:
Q9NPD5
Molecular Weight:
77402.175 Da
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Drug created on May 08, 2015 13:47 / Updated on September 25, 2016 02:17