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Identification
NameOlaparib
Accession NumberDB09074
TypeSmall Molecule
GroupsApproved
DescriptionLynparza is an inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, including PARP1, PARP2, and PARP3. PARP enzymes are involved in normal cellular homeostasis, such as DNA transcription, cell cycle regulation, and DNA repair. Olaparib has been shown to inhibit growth of select tumor cell lines in vitro and decrease tumor growth in mouse xenograft models of human cancer both as monotherapy or following platinum-based chemotherapy. Increased cytotoxicity and anti-tumor activity following treatment with olaparib were noted in cell lines and mouse tumor models with deficiencies in BRCA. In vitro studies have shown that olaparib-induced cytotoxicity may involve inhibition of PARP enzymatic activity and increased formation of PARP-DNA complex, resulting in disruption of cellular homeostasis and cell death.
Structure
Thumb
Synonyms
4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2H)-one
External Identifiers
  • AZD 2281
  • AZD-2281
  • AZD2281
  • KU59436
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Lynparzacapsule50 mg/1oralAstra Zeneca Pharmaceuticals Lp2014-12-24Not applicableUs
Lynparzacapsule50 mgoralAstrazeneca Canada Inc2016-05-16Not applicableCanada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIWOH1JD9AR8
CAS number763113-22-0
WeightAverage:
Monoisotopic:
Chemical FormulaNot Available
InChI KeyNot Available
InChI
IUPAC Name
4-{[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorophenyl]methyl}phthalazin-1-ol
SMILES
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phthalazinones. These are compounds containing a phthalazine bearing a ketone group.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassNaphthyridines
Sub ClassPhthalazines
Direct ParentPhthalazinones
Alternative Parents
Substituents
  • Phthalazinone
  • Halobenzoic acid or derivatives
  • 2-halobenzoic acid or derivatives
  • Benzoic acid or derivatives
  • Benzamide
  • Benzoyl
  • Pyridazinone
  • Halobenzene
  • Fluorobenzene
  • Benzenoid
  • Pyridazine
  • Piperazine
  • 1,4-diazinane
  • Cyclopropanecarboxylic acid or derivatives
  • Monocyclic benzene moiety
  • Aryl halide
  • Aryl fluoride
  • Heteroaromatic compound
  • Vinylogous halide
  • Tertiary carboxylic acid amide
  • Tertiary amine
  • Lactam
  • Carboxamide group
  • Azacycle
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organofluoride
  • Organohalogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationOlaparib is a poly (ADP-ribose) polymerase (PARP) inhibitor indicated as monotherapy in patients with deleterious or suspected deleterious germline BRCA mutated (as detected by an FDA-approved test) advanced ovarian cancer who have been treated with three or more prior lines of chemotherapy.
PharmacodynamicsNot Available
Mechanism of actionOlaparib is an inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, including PARP1, PARP2, and PARP3. PARP enzymes are involved in normal cellular homeostasis, such as DNA transcription, cell cycle regulation, and DNA repair. Olaparib has been shown to inhibit growth of select tumor cell lines in vitro and decrease tumor growth in mouse xenograft models of human cancer both as monotherapy or following platinum-based chemotherapy. Increased cytotoxicity and anti-tumor activity following treatment with olaparib were noted in cell lines and mouse tumor models with deficiencies in BRCA. In vitro studies have shown that olaparib-induced cytotoxicity may involve inhibition of PARP enzymatic activity and increased formation of PARP-DNA complex, resulting in disruption of cellular homeostasis and cell death.
Related Articles
AbsorptionPeak plasma concentrations achieved typically between 1 to 3 hours following oral administration of olaparib in capsule formulation.
Volume of distribution

167 +/-196 L following a single dose of 400mg olaparib.

Protein bindingApproximately 82%.
Metabolism

Primarily CYP3A4 in vitro.

Route of elimination44% via the urine and 42% via the feces.
Half life11.9 hours, standard deviation 4.8 hours.
Clearance

8.6 +/- 7.1L/h.

ToxicityThe most commonly reported side effects reported during clinical trials included cough, constipation, dysguesia, peripheral deem, back pain, dizziness, headache, urinary tract infection, dyspnea, and rash. Myelodysplastic syndrome/Acute Myeloid Leukemia (MDS/AML) was reported in 2% of patients with deleterious or suspected deleterious germline BRCA-mutated advanced cancers. The majority of cases were fatal and the duration of therapy with olaparib in patients who developed secondary cancers varied from <6 months to >2 years. Complete blood count should be tested at baseline and monthly following therapy initiation to monitor for MDS/AML. Pneumonitis, including fatal cases, occurred in <1% of patients treated with olaparib. Patients should be monitored for new or worsening respiratory symptoms such as dyspnea, fever, cough, or wheezing. Olaparib was found to be teratogenic and causes embryo-fetal toxicity in rats. It should therefore be avoided during pregnancy and its use should be a combined with an effective contraception during treatment.
Affected organismsNot Available
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal AbsorptionNot AvailableNot Available
Blood Brain BarrierNot AvailableNot Available
Caco-2 permeableNot AvailableNot Available
P-glycoprotein substrateNot AvailableNot Available
P-glycoprotein inhibitor INot AvailableNot Available
P-glycoprotein inhibitor IINot AvailableNot Available
Renal organic cation transporterNot AvailableNot Available
CYP450 2C9 substrateNot AvailableNot Available
CYP450 2D6 substrateNot AvailableNot Available
CYP450 3A4 substrateNot AvailableNot Available
CYP450 1A2 substrateNot AvailableNot Available
CYP450 2C9 inhibitorNot AvailableNot Available
CYP450 2D6 inhibitorNot AvailableNot Available
CYP450 2C19 inhibitorNot AvailableNot Available
CYP450 3A4 inhibitorNot AvailableNot Available
CYP450 inhibitory promiscuityNot AvailableNot Available
Ames testNot AvailableNot Available
CarcinogenicityNot AvailableNot Available
BiodegradationNot AvailableNot Available
Rat acute toxicityNot AvailableNot applicable
hERG inhibition (predictor I)Not AvailableNot Available
hERG inhibition (predictor II)Not AvailableNot Available
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
Capsuleoral50 mg/1
Capsuleoral50 mg
PricesNot Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US7151102 No2002-04-292022-04-29Us
US7449464 No2004-10-112024-10-11Us
US7981889 No2004-10-112024-10-11Us
US8143241 No2007-08-122027-08-12Us
US8247416 No2008-09-242028-09-24Us
US8859562 No2011-08-042031-08-04Us
US8912187 No2004-03-122024-03-12Us
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.119 mg/mLALOGPS
logP2.68ALOGPS
logP2.32ChemAxon
logS-3.6ALOGPS
pKa (Strongest Acidic)8.75ChemAxon
pKa (Strongest Basic)2.21ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area86.63 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity118.63 m3·mol-1ChemAxon
Polarizability44.03 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference
  1. Menear KA, Adcock C, Boulter R, Cockcroft XL, Copsey L, Cranston A, Dillon KJ, Drzewiecki J, Garman S, Gomez S, Javaid H, Kerrigan F, Knights C, Lau A, Loh VM Jr, Matthews IT, Moore S, O’Connor MJ, Smith GC, Martin NM: 4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin- 1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1. J Med Chem. 2008 Oct 23;51(20):6581-91. doi: 10.1021/jm8001263. Epub 2008 Sep 19. Pubmed
General References
  1. Frampton JE: Olaparib: a review of its use as maintenance therapy in patients with ovarian cancer. BioDrugs. 2015 Apr;29(2):143-50. doi: 10.1007/s40259-015-0125-6. [PubMed:25899311 ]
  2. Menear KA, Adcock C, Boulter R, Cockcroft XL, Copsey L, Cranston A, Dillon KJ, Drzewiecki J, Garman S, Gomez S, Javaid H, Kerrigan F, Knights C, Lau A, Loh VM Jr, Matthews IT, Moore S, O'Connor MJ, Smith GC, Martin NM: 4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin- 1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1. J Med Chem. 2008 Oct 23;51(20):6581-91. doi: 10.1021/jm8001263. Epub 2008 Sep 19. [PubMed:18800822 ]
  3. Hay T, Matthews JR, Pietzka L, Lau A, Cranston A, Nygren AO, Douglas-Jones A, Smith GC, Martin NM, O'Connor M, Clarke AR: Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin. Cancer Res. 2009 May 1;69(9):3850-5. doi: 10.1158/0008-5472.CAN-08-2388. Epub 2009 Apr 21. [PubMed:19383921 ]
  4. Rottenberg S, Jaspers JE, Kersbergen A, van der Burg E, Nygren AO, Zander SA, Derksen PW, de Bruin M, Zevenhoven J, Lau A, Boulter R, Cranston A, O'Connor MJ, Martin NM, Borst P, Jonkers J: High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17079-84. doi: 10.1073/pnas.0806092105. Epub 2008 Oct 29. [PubMed:18971340 ]
External Links
ATC CodesL01XX46
AHFS Codes
  • 10:00
PDB EntriesNot Available
FDA labelDownload (297 KB)
MSDSNot Available
Interactions
Drug Interactions
Drug
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Olaparib.
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Olaparib.
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Olaparib.
AcetyldigitoxinAcetyldigitoxin may decrease the cardiotoxic activities of Olaparib.
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Olaparib.
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Olaparib.
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Olaparib.
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Olaparib.
AlfuzosinThe metabolism of Alfuzosin can be decreased when combined with Olaparib.
AliskirenThe metabolism of Aliskiren can be decreased when combined with Olaparib.
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Olaparib.
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Olaparib.
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Olaparib.
AlosetronThe metabolism of Alosetron can be decreased when combined with Olaparib.
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Olaparib.
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Olaparib.
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Olaparib.
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Olaparib.
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Olaparib.
AmiodaroneThe serum concentration of Olaparib can be increased when it is combined with Amiodarone.
AmiodaroneThe metabolism of Amiodarone can be decreased when combined with Olaparib.
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Olaparib.
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Olaparib.
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Olaparib.
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Olaparib.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Olaparib.
ApremilastThe metabolism of Apremilast can be decreased when combined with Olaparib.
AprepitantThe serum concentration of Olaparib can be increased when it is combined with Aprepitant.
AprepitantThe metabolism of Aprepitant can be decreased when combined with Olaparib.
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Olaparib.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Olaparib.
ArtemetherThe metabolism of Artemether can be decreased when combined with Olaparib.
AsenapineThe metabolism of Asenapine can be decreased when combined with Olaparib.
AstemizoleThe metabolism of Astemizole can be decreased when combined with Olaparib.
AtazanavirThe serum concentration of Olaparib can be increased when it is combined with Atazanavir.
AtazanavirThe metabolism of Atazanavir can be decreased when combined with Olaparib.
AtomoxetineThe serum concentration of Olaparib can be increased when it is combined with Atomoxetine.
AtorvastatinThe metabolism of Atorvastatin can be decreased when combined with Olaparib.
AvanafilThe metabolism of Avanafil can be decreased when combined with Olaparib.
AxitinibThe metabolism of Axitinib can be decreased when combined with Olaparib.
AzelastineThe metabolism of Azelastine can be decreased when combined with Olaparib.
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Olaparib.
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Olaparib.
BedaquilineThe metabolism of Bedaquiline can be decreased when combined with Olaparib.
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Olaparib.
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Olaparib.
BevacizumabBevacizumab may increase the cardiotoxic activities of Olaparib.
BexaroteneThe serum concentration of Olaparib can be decreased when it is combined with Bexarotene.
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Olaparib.
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Olaparib.
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Olaparib.
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Olaparib.
BoceprevirThe serum concentration of Olaparib can be increased when it is combined with Boceprevir.
BoceprevirThe metabolism of Boceprevir can be decreased when combined with Olaparib.
BortezomibThe serum concentration of Olaparib can be increased when it is combined with Bortezomib.
BortezomibThe metabolism of Bortezomib can be decreased when combined with Olaparib.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Olaparib.
BosentanThe serum concentration of Olaparib can be decreased when it is combined with Bosentan.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Olaparib.
Brentuximab vedotinThe metabolism of Brentuximab vedotin can be decreased when combined with Olaparib.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Olaparib.
BrinzolamideThe metabolism of Brinzolamide can be decreased when combined with Olaparib.
BromazepamThe metabolism of Bromazepam can be decreased when combined with Olaparib.
BromocriptineThe metabolism of Bromocriptine can be decreased when combined with Olaparib.
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Olaparib.
BudesonideThe metabolism of Budesonide can be decreased when combined with Olaparib.
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Olaparib.
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Olaparib.
BupropionThe metabolism of Bupropion can be decreased when combined with Olaparib.
BuspironeThe metabolism of Buspirone can be decreased when combined with Olaparib.
BusulfanThe metabolism of Busulfan can be decreased when combined with Olaparib.
CabazitaxelThe metabolism of Cabazitaxel can be decreased when combined with Olaparib.
CabazitaxelThe risk or severity of adverse effects can be increased when Cabazitaxel is combined with Olaparib.
CabergolineThe metabolism of Cabergoline can be decreased when combined with Olaparib.
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Olaparib.
CaffeineThe metabolism of Caffeine can be decreased when combined with Olaparib.
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Olaparib.
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Olaparib.
CarbamazepineThe serum concentration of Olaparib can be decreased when it is combined with Carbamazepine.
CarbamazepineThe metabolism of Carbamazepine can be decreased when combined with Olaparib.
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Olaparib.
CariprazineThe metabolism of Cariprazine can be decreased when combined with Olaparib.
CarvedilolThe metabolism of Carvedilol can be decreased when combined with Olaparib.
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Olaparib.
CeliprololThe metabolism of Celiprolol can be decreased when combined with Olaparib.
CephalexinThe metabolism of Cephalexin can be decreased when combined with Olaparib.
CeritinibThe serum concentration of Olaparib can be increased when it is combined with Ceritinib.
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Olaparib.
CevimelineThe metabolism of Cevimeline can be decreased when combined with Olaparib.
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Olaparib.
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Olaparib.
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Olaparib.
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Olaparib.
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Olaparib.
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Olaparib.
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Olaparib.
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Olaparib.
CilostazolThe metabolism of Cilostazol can be decreased when combined with Olaparib.
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Olaparib.
CisaprideThe metabolism of Cisapride can be decreased when combined with Olaparib.
CitalopramThe metabolism of Citalopram can be decreased when combined with Olaparib.
ClarithromycinThe serum concentration of Olaparib can be increased when it is combined with Clarithromycin.
ClarithromycinThe metabolism of Clarithromycin can be decreased when combined with Olaparib.
ClemastineThe serum concentration of Olaparib can be increased when it is combined with Clemastine.
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Olaparib.
ClobazamThe metabolism of Clobazam can be decreased when combined with Olaparib.
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Olaparib.
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Olaparib.
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Olaparib.
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Olaparib.
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Olaparib.
ClonidineThe metabolism of Clonidine can be decreased when combined with Olaparib.
ClopidogrelThe metabolism of Clopidogrel can be decreased when combined with Olaparib.
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Olaparib.
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Olaparib.
ClotrimazoleThe serum concentration of Olaparib can be increased when it is combined with Clotrimazole.
ClozapineThe risk or severity of adverse effects can be increased when Olaparib is combined with Clozapine.
CobicistatThe serum concentration of Olaparib can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Olaparib.
CocaineThe metabolism of Cocaine can be decreased when combined with Olaparib.
CodeineThe metabolism of Codeine can be decreased when combined with Olaparib.
ColchicineThe metabolism of Colchicine can be decreased when combined with Olaparib.
ConivaptanThe serum concentration of Olaparib can be increased when it is combined with Conivaptan.
ConivaptanThe metabolism of Conivaptan can be decreased when combined with Olaparib.
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be decreased when combined with Olaparib.
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Olaparib.
CrizotinibThe serum concentration of Olaparib can be increased when it is combined with Crizotinib.
CrizotinibThe metabolism of Crizotinib can be decreased when combined with Olaparib.
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Olaparib.
CyclophosphamideCyclophosphamide may increase the cardiotoxic activities of Olaparib.
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Olaparib.
CyclosporineThe serum concentration of Olaparib can be increased when it is combined with Cyclosporine.
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Olaparib.
CytarabineThe metabolism of Cytarabine can be decreased when combined with Olaparib.
DabrafenibThe serum concentration of Olaparib can be decreased when it is combined with Dabrafenib.
DabrafenibThe metabolism of Dabrafenib can be decreased when combined with Olaparib.
DaclatasvirThe metabolism of Daclatasvir can be decreased when combined with Olaparib.
DantroleneThe metabolism of Dantrolene can be decreased when combined with Olaparib.
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Olaparib.
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Olaparib.
DapsoneThe metabolism of Dapsone can be decreased when combined with Olaparib.
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Olaparib.
DarunavirThe serum concentration of Olaparib can be increased when it is combined with Darunavir.
DarunavirThe metabolism of Darunavir can be decreased when combined with Olaparib.
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Olaparib.
DasatinibThe serum concentration of Olaparib can be increased when it is combined with Dasatinib.
DasatinibThe metabolism of Dasatinib can be decreased when combined with Olaparib.
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Olaparib.
DeferasiroxThe serum concentration of Olaparib can be decreased when it is combined with Deferasirox.
DehydroepiandrosteroneThe metabolism of Dehydroepiandrosterone can be decreased when combined with Olaparib.
DelavirdineThe serum concentration of Olaparib can be increased when it is combined with Delavirdine.
DelavirdineThe metabolism of Delavirdine can be decreased when combined with Olaparib.
DeslanosideDeslanoside may decrease the cardiotoxic activities of Olaparib.
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Olaparib.
DexamethasoneThe serum concentration of Olaparib can be decreased when it is combined with Dexamethasone.
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Olaparib.
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Olaparib.
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Olaparib.
DiazepamThe metabolism of Diazepam can be decreased when combined with Olaparib.
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Olaparib.
DigitoxinDigitoxin may decrease the cardiotoxic activities of Olaparib.
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Olaparib.
DigoxinDigoxin may decrease the cardiotoxic activities of Olaparib.
DigoxinThe metabolism of Digoxin can be decreased when combined with Olaparib.
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Olaparib.
DihydroergotamineThe serum concentration of Olaparib can be increased when it is combined with Dihydroergotamine.
DihydroergotamineThe metabolism of Dihydroergotamine can be decreased when combined with Olaparib.
DiltiazemThe serum concentration of Olaparib can be increased when it is combined with Diltiazem.
DiltiazemThe metabolism of Diltiazem can be decreased when combined with Olaparib.
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Olaparib.
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Olaparib.
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Olaparib.
DocetaxelThe risk or severity of adverse effects can be increased when Docetaxel is combined with Olaparib.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Olaparib.
DolasetronThe metabolism of Dolasetron can be decreased when combined with Olaparib.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Olaparib.
DonepezilThe metabolism of Donepezil can be decreased when combined with Olaparib.
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Olaparib.
DoxepinThe metabolism of Doxepin can be decreased when combined with Olaparib.
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Olaparib.
DoxycyclineThe serum concentration of Olaparib can be increased when it is combined with Doxycycline.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Olaparib.
DronedaroneThe serum concentration of Olaparib can be increased when it is combined with Dronedarone.
DronedaroneThe metabolism of Dronedarone can be decreased when combined with Olaparib.
DutasterideThe metabolism of Dutasteride can be decreased when combined with Olaparib.
EfavirenzThe serum concentration of Olaparib can be decreased when it is combined with Efavirenz.
EfavirenzThe metabolism of Efavirenz can be decreased when combined with Olaparib.
EletriptanThe metabolism of Eletriptan can be decreased when combined with Olaparib.
EliglustatThe metabolism of Eliglustat can be decreased when combined with Olaparib.
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Olaparib.
EnalaprilThe metabolism of Enalapril can be decreased when combined with Olaparib.
EnzalutamideThe serum concentration of Olaparib can be decreased when it is combined with Enzalutamide.
EnzalutamideThe metabolism of Enzalutamide can be decreased when combined with Olaparib.
EpinastineThe metabolism of Epinastine can be decreased when combined with Olaparib.
EplerenoneThe metabolism of Eplerenone can be decreased when combined with Olaparib.
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Olaparib.
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Olaparib.
ErgonovineThe metabolism of Ergonovine can be decreased when combined with Olaparib.
ErgotamineThe metabolism of Ergotamine can be decreased when combined with Olaparib.
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Olaparib.
ErythromycinThe serum concentration of Olaparib can be increased when it is combined with Erythromycin.
ErythromycinThe metabolism of Erythromycin can be decreased when combined with Olaparib.
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Olaparib.
Eslicarbazepine acetateThe serum concentration of Olaparib can be decreased when it is combined with Eslicarbazepine acetate.
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Olaparib.
EstazolamThe metabolism of Estazolam can be decreased when combined with Olaparib.
EstradiolThe metabolism of Estradiol can be decreased when combined with Olaparib.
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Olaparib.
EstramustineThe metabolism of Estramustine can be decreased when combined with Olaparib.
EstroneThe metabolism of Estrone can be decreased when combined with Olaparib.
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Olaparib.
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Olaparib.
EthanolThe metabolism of Ethanol can be decreased when combined with Olaparib.
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Olaparib.
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Olaparib.
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Olaparib.
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Olaparib.
EtoposideThe metabolism of Etoposide can be decreased when combined with Olaparib.
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Olaparib.
EtravirineThe serum concentration of Olaparib can be decreased when it is combined with Etravirine.
EtravirineThe metabolism of Etravirine can be decreased when combined with Olaparib.
EverolimusThe metabolism of Everolimus can be decreased when combined with Olaparib.
ExemestaneThe metabolism of Exemestane can be decreased when combined with Olaparib.
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Olaparib.
FelbamateThe metabolism of Felbamate can be decreased when combined with Olaparib.
FelodipineThe metabolism of Felodipine can be decreased when combined with Olaparib.
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Olaparib.
FentanylThe metabolism of Fentanyl can be decreased when combined with Olaparib.
FesoterodineThe metabolism of Fesoterodine can be decreased when combined with Olaparib.
FinasterideThe metabolism of Finasteride can be decreased when combined with Olaparib.
FingolimodThe metabolism of Fingolimod can be decreased when combined with Olaparib.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Olaparib.
FluconazoleThe serum concentration of Olaparib can be increased when it is combined with Fluconazole.
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Olaparib.
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Olaparib.
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Olaparib.
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Olaparib.
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Olaparib.
FlutamideThe metabolism of Flutamide can be decreased when combined with Olaparib.
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Olaparib.
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be decreased when combined with Olaparib.
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Olaparib.
FluvoxamineThe serum concentration of Olaparib can be increased when it is combined with Fluvoxamine.
FosamprenavirThe serum concentration of Olaparib can be increased when it is combined with Fosamprenavir.
FosamprenavirThe metabolism of Fosamprenavir can be decreased when combined with Olaparib.
FosaprepitantThe serum concentration of Olaparib can be increased when it is combined with Fosaprepitant.
FosphenytoinThe serum concentration of Olaparib can be decreased when it is combined with Fosphenytoin.
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Olaparib.
Fusidic AcidThe serum concentration of Olaparib can be increased when it is combined with Fusidic Acid.
GalantamineThe metabolism of Galantamine can be decreased when combined with Olaparib.
GefitinibThe metabolism of Gefitinib can be decreased when combined with Olaparib.
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Olaparib.
GlipizideThe metabolism of Glipizide can be decreased when combined with Olaparib.
GlyburideThe metabolism of Glyburide can be decreased when combined with Olaparib.
GranisetronThe metabolism of Granisetron can be decreased when combined with Olaparib.
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Olaparib.
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Olaparib.
HalofantrineThe metabolism of Halofantrine can be decreased when combined with Olaparib.
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Olaparib.
HalothaneThe metabolism of Halothane can be decreased when combined with Olaparib.
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Olaparib.
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Olaparib.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Olaparib.
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Olaparib.
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Olaparib.
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Olaparib.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Olaparib.
IdelalisibThe serum concentration of Olaparib can be increased when it is combined with Idelalisib.
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Olaparib resulting in a loss in efficacy.
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Olaparib.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Olaparib.
ImipramineThe metabolism of Imipramine can be decreased when combined with Olaparib.
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Olaparib.
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Olaparib.
IndapamideThe metabolism of Indapamide can be decreased when combined with Olaparib.
IndinavirThe serum concentration of Olaparib can be increased when it is combined with Indinavir.
IndinavirThe metabolism of Indinavir can be decreased when combined with Olaparib.
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Olaparib.
IrinotecanThe metabolism of Irinotecan can be decreased when combined with Olaparib.
IsavuconazoniumThe serum concentration of Olaparib can be increased when it is combined with Isavuconazonium.
IsavuconazoniumThe metabolism of Isavuconazonium can be decreased when combined with Olaparib.
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Olaparib.
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Olaparib.
IsradipineThe serum concentration of Olaparib can be increased when it is combined with Isradipine.
IsradipineThe metabolism of Isradipine can be decreased when combined with Olaparib.
ItraconazoleThe serum concentration of Olaparib can be increased when it is combined with Itraconazole.
ItraconazoleThe metabolism of Itraconazole can be decreased when combined with Olaparib.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Olaparib.
IvacaftorThe serum concentration of Olaparib can be increased when it is combined with Ivacaftor.
IvacaftorThe metabolism of Ivacaftor can be decreased when combined with Olaparib.
IvermectinThe metabolism of Ivermectin can be decreased when combined with Olaparib.
IxabepiloneThe metabolism of Ixabepilone can be decreased when combined with Olaparib.
IxazomibThe metabolism of Ixazomib can be decreased when combined with Olaparib.
KetamineThe metabolism of Ketamine can be decreased when combined with Olaparib.
KetazolamThe metabolism of Ketazolam can be decreased when combined with Olaparib.
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Olaparib.
KetoconazoleThe serum concentration of Olaparib can be increased when it is combined with Ketoconazole.
KetoconazoleThe metabolism of Ketoconazole can be decreased when combined with Olaparib.
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Olaparib.
LapatinibThe metabolism of Lapatinib can be decreased when combined with Olaparib.
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Olaparib.
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Olaparib.
LercanidipineThe metabolism of Lercanidipine can be decreased when combined with Olaparib.
LetrozoleThe metabolism of Letrozole can be decreased when combined with Olaparib.
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Olaparib.
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Olaparib.
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Olaparib.
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Olaparib.
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Olaparib.
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Olaparib.
LidocaineThe metabolism of Lidocaine can be decreased when combined with Olaparib.
LisurideThe metabolism of Lisuride can be decreased when combined with Olaparib.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Olaparib.
LoperamideThe metabolism of Loperamide can be decreased when combined with Olaparib.
LopinavirThe serum concentration of Olaparib can be increased when it is combined with Lopinavir.
LopinavirThe metabolism of Lopinavir can be decreased when combined with Olaparib.
LoratadineThe metabolism of Loratadine can be decreased when combined with Olaparib.
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Olaparib.
LosartanThe metabolism of Losartan can be decreased when combined with Olaparib.
LovastatinThe serum concentration of Olaparib can be increased when it is combined with Lovastatin.
LovastatinThe metabolism of Lovastatin can be decreased when combined with Olaparib.
LuliconazoleThe serum concentration of Olaparib can be increased when it is combined with Luliconazole.
LumefantrineThe metabolism of Lumefantrine can be decreased when combined with Olaparib.
LurasidoneThe metabolism of Lurasidone can be decreased when combined with Olaparib.
MacitentanThe metabolism of Macitentan can be decreased when combined with Olaparib.
MaravirocThe metabolism of Maraviroc can be decreased when combined with Olaparib.
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Olaparib.
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be decreased when combined with Olaparib.
MefloquineThe metabolism of Mefloquine can be decreased when combined with Olaparib.
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Olaparib.
MetamizoleThe risk or severity of adverse effects can be increased when Metamizole is combined with Olaparib.
MethadoneThe metabolism of Methadone can be decreased when combined with Olaparib.
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Olaparib.
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Olaparib.
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Olaparib.
MethylprednisoloneThe metabolism of Methylprednisolone can be decreased when combined with Olaparib.
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Olaparib.
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Olaparib.
MexiletineThe metabolism of Mexiletine can be decreased when combined with Olaparib.
MianserinThe metabolism of Mianserin can be decreased when combined with Olaparib.
MibefradilThe metabolism of Mibefradil can be decreased when combined with Olaparib.
MiconazoleThe metabolism of Miconazole can be decreased when combined with Olaparib.
MidazolamThe metabolism of Midazolam can be decreased when combined with Olaparib.
MifepristoneThe serum concentration of Olaparib can be increased when it is combined with Mifepristone.
MifepristoneThe metabolism of Mifepristone can be decreased when combined with Olaparib.
MirabegronThe metabolism of Mirabegron can be decreased when combined with Olaparib.
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Olaparib.
MitotaneThe serum concentration of Olaparib can be decreased when it is combined with Mitotane.
ModafinilThe serum concentration of Olaparib can be decreased when it is combined with Modafinil.
ModafinilThe metabolism of Modafinil can be decreased when combined with Olaparib.
MontelukastThe metabolism of Montelukast can be decreased when combined with Olaparib.
MorphineThe metabolism of Morphine can be decreased when combined with Olaparib.
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Olaparib.
NafcillinThe serum concentration of Olaparib can be decreased when it is combined with Nafcillin.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Olaparib.
NaloxoneThe metabolism of Naloxone can be decreased when combined with Olaparib.
NateglinideThe metabolism of Nateglinide can be decreased when combined with Olaparib.
NefazodoneThe serum concentration of Olaparib can be increased when it is combined with Nefazodone.
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Olaparib.
NelfinavirThe serum concentration of Olaparib can be increased when it is combined with Nelfinavir.
NelfinavirThe metabolism of Nelfinavir can be decreased when combined with Olaparib.
NetupitantThe serum concentration of Olaparib can be increased when it is combined with Netupitant.
NevirapineThe serum concentration of Olaparib can be increased when it is combined with Nevirapine.
NevirapineThe metabolism of Nevirapine can be decreased when combined with Olaparib.
NicardipineThe metabolism of Nicardipine can be decreased when combined with Olaparib.
NicotineThe metabolism of Nicotine can be decreased when combined with Olaparib.
NifedipineThe metabolism of Nifedipine can be decreased when combined with Olaparib.
NilotinibThe serum concentration of Olaparib can be increased when it is combined with Nilotinib.
NilotinibThe metabolism of Nilotinib can be decreased when combined with Olaparib.
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Olaparib.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Olaparib.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Olaparib.
NisoldipineThe metabolism of Nisoldipine can be decreased when combined with Olaparib.
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Olaparib.
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Olaparib.
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Olaparib.
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Olaparib.
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Olaparib.
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Olaparib.
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Olaparib.
OndansetronThe metabolism of Ondansetron can be decreased when combined with Olaparib.
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Olaparib.
OsimertinibThe serum concentration of Olaparib can be increased when it is combined with Osimertinib.
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Olaparib.
OuabainOuabain may decrease the cardiotoxic activities of Olaparib.
OxazepamThe metabolism of Oxazepam can be decreased when combined with Olaparib.
OxybutyninThe metabolism of Oxybutynin can be decreased when combined with Olaparib.
OxycodoneThe metabolism of Oxycodone can be decreased when combined with Olaparib.
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Olaparib.
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Olaparib.
PaclitaxelThe risk or severity of adverse effects can be increased when Paclitaxel is combined with Olaparib.
PalbociclibThe serum concentration of Olaparib can be increased when it is combined with Palbociclib.
PalbociclibThe metabolism of Palbociclib can be decreased when combined with Olaparib.
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Olaparib.
PanobinostatThe metabolism of Panobinostat can be decreased when combined with Olaparib.
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Olaparib.
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Olaparib.
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Olaparib.
ParecoxibThe metabolism of Parecoxib can be decreased when combined with Olaparib.
ParicalcitolThe metabolism of Paricalcitol can be decreased when combined with Olaparib.
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Olaparib.
PazopanibThe metabolism of Pazopanib can be decreased when combined with Olaparib.
PentamidineThe metabolism of Pentamidine can be decreased when combined with Olaparib.
PentobarbitalThe serum concentration of Olaparib can be decreased when it is combined with Pentobarbital.
PerampanelThe metabolism of Perampanel can be decreased when combined with Olaparib.
PergolideThe metabolism of Pergolide can be decreased when combined with Olaparib.
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Olaparib.
PermethrinThe metabolism of Permethrin can be decreased when combined with Olaparib.
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Olaparib.
PethidineThe metabolism of Pethidine can be decreased when combined with Olaparib.
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Olaparib.
PhenobarbitalThe serum concentration of Olaparib can be decreased when it is combined with Phenobarbital.
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Olaparib.
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Olaparib.
PhenytoinThe serum concentration of Olaparib can be decreased when it is combined with Phenytoin.
PhenytoinThe metabolism of Phenytoin can be decreased when combined with Olaparib.
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Olaparib.
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Olaparib.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Olaparib.
PinacidilThe metabolism of Pinacidil can be decreased when combined with Olaparib.
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Olaparib.
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Olaparib.
PodofiloxThe metabolism of Podofilox can be decreased when combined with Olaparib.
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Olaparib.
PonatinibThe metabolism of Ponatinib can be decreased when combined with Olaparib.
PosaconazoleThe serum concentration of Olaparib can be increased when it is combined with Posaconazole.
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Olaparib.
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Olaparib.
PravastatinThe metabolism of Pravastatin can be decreased when combined with Olaparib.
PrazepamThe metabolism of Prazepam can be decreased when combined with Olaparib.
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Olaparib.
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Olaparib.
PrednisoneThe metabolism of Prednisone can be decreased when combined with Olaparib.
PrimaquineThe metabolism of Primaquine can be decreased when combined with Olaparib.
PrimidoneThe serum concentration of Olaparib can be decreased when it is combined with Primidone.
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Olaparib.
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Olaparib.
ProguanilThe metabolism of Proguanil can be decreased when combined with Olaparib.
PromazineThe metabolism of Promazine can be decreased when combined with Olaparib.
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Olaparib.
PropofolThe metabolism of Propofol can be decreased when combined with Olaparib.
PropranololThe metabolism of Propranolol can be decreased when combined with Olaparib.
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Olaparib.
QuazepamThe metabolism of Quazepam can be decreased when combined with Olaparib.
QuetiapineThe metabolism of Quetiapine can be decreased when combined with Olaparib.
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Olaparib.
QuinidineThe metabolism of Quinidine can be decreased when combined with Olaparib.
QuinineThe metabolism of Quinine can be decreased when combined with Olaparib.
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Olaparib.
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Olaparib.
RamelteonThe metabolism of Ramelteon can be decreased when combined with Olaparib.
RanolazineThe serum concentration of Olaparib can be increased when it is combined with Ranolazine.
RanolazineThe metabolism of Ranolazine can be decreased when combined with Olaparib.
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Olaparib.
RegorafenibThe metabolism of Regorafenib can be decreased when combined with Olaparib.
RepaglinideThe metabolism of Repaglinide can be decreased when combined with Olaparib.
RetapamulinThe metabolism of Retapamulin can be decreased when combined with Olaparib.
RifabutinThe serum concentration of Olaparib can be decreased when it is combined with Rifabutin.
RifabutinThe metabolism of Rifabutin can be decreased when combined with Olaparib.
RifampicinThe serum concentration of Olaparib can be decreased when it is combined with Rifampicin.
RifampicinThe metabolism of Rifampicin can be decreased when combined with Olaparib.
RifapentineThe serum concentration of Olaparib can be decreased when it is combined with Rifapentine.
RilpivirineThe metabolism of Rilpivirine can be decreased when combined with Olaparib.
RimonabantThe metabolism of Rimonabant can be decreased when combined with Olaparib.
RiociguatThe metabolism of Riociguat can be decreased when combined with Olaparib.
RisperidoneThe metabolism of Risperidone can be decreased when combined with Olaparib.
RitonavirThe serum concentration of Olaparib can be increased when it is combined with Ritonavir.
RitonavirThe metabolism of Ritonavir can be decreased when combined with Olaparib.
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Olaparib.
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Olaparib.
RolapitantThe metabolism of Rolapitant can be decreased when combined with Olaparib.
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Olaparib.
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Olaparib.
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Olaparib.
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Olaparib.
RotigotineThe metabolism of Rotigotine can be decreased when combined with Olaparib.
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Olaparib.
RuxolitinibThe metabolism of Ruxolitinib can be decreased when combined with Olaparib.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Olaparib.
SaquinavirThe serum concentration of Olaparib can be increased when it is combined with Saquinavir.
SaquinavirThe metabolism of Saquinavir can be decreased when combined with Olaparib.
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Olaparib.
SelegilineThe metabolism of Selegiline can be decreased when combined with Olaparib.
SelexipagThe metabolism of Selexipag can be decreased when combined with Olaparib.
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Olaparib.
SertindoleThe metabolism of Sertindole can be decreased when combined with Olaparib.
SertralineThe metabolism of Sertraline can be decreased when combined with Olaparib.
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Olaparib.
SibutramineThe metabolism of Sibutramine can be decreased when combined with Olaparib.
SildenafilThe serum concentration of Olaparib can be increased when it is combined with Sildenafil.
SildenafilThe metabolism of Sildenafil can be decreased when combined with Olaparib.
SilodosinThe metabolism of Silodosin can be decreased when combined with Olaparib.
SiltuximabThe serum concentration of Olaparib can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Olaparib can be increased when it is combined with Simeprevir.
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Olaparib.
SirolimusThe metabolism of Sirolimus can be decreased when combined with Olaparib.
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Olaparib.
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Olaparib.
SonidegibThe metabolism of Sonidegib can be decreased when combined with Olaparib.
SorafenibThe metabolism of Sorafenib can be decreased when combined with Olaparib.
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Olaparib.
St. John's WortThe serum concentration of Olaparib can be decreased when it is combined with St. John&#39;s Wort.
StiripentolThe serum concentration of Olaparib can be increased when it is combined with Stiripentol.
SufentanilThe metabolism of Sufentanil can be decreased when combined with Olaparib.
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Olaparib.
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Olaparib.
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Olaparib.
SulfisoxazoleThe serum concentration of Olaparib can be increased when it is combined with Sulfisoxazole.
SunitinibThe metabolism of Sunitinib can be decreased when combined with Olaparib.
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Olaparib.
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Olaparib.
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Olaparib.
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Olaparib.
TadalafilThe metabolism of Tadalafil can be decreased when combined with Olaparib.
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Olaparib.
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Olaparib.
TasosartanThe metabolism of Tasosartan can be decreased when combined with Olaparib.
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Olaparib.
TelaprevirThe serum concentration of Olaparib can be increased when it is combined with Telaprevir.
TelaprevirThe metabolism of Telaprevir can be decreased when combined with Olaparib.
TelithromycinThe serum concentration of Olaparib can be increased when it is combined with Telithromycin.
TelithromycinThe metabolism of Telithromycin can be decreased when combined with Olaparib.
TemazepamThe metabolism of Temazepam can be decreased when combined with Olaparib.
TemsirolimusThe metabolism of Temsirolimus can be decreased when combined with Olaparib.
TeniposideThe metabolism of Teniposide can be decreased when combined with Olaparib.
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Olaparib.
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Olaparib.
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Olaparib.
TestosteroneThe metabolism of Testosterone can be decreased when combined with Olaparib.
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Olaparib.
TheophyllineThe metabolism of Theophylline can be decreased when combined with Olaparib.
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Olaparib.
TiagabineThe metabolism of Tiagabine can be decreased when combined with Olaparib.
TicagrelorThe metabolism of Ticagrelor can be decreased when combined with Olaparib.
TiclopidineThe serum concentration of Olaparib can be increased when it is combined with Ticlopidine.
TiclopidineThe metabolism of Ticlopidine can be decreased when combined with Olaparib.
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Olaparib.
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Olaparib.
TipranavirThe metabolism of Tipranavir can be decreased when combined with Olaparib.
TocilizumabThe serum concentration of Olaparib can be decreased when it is combined with Tocilizumab.
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Olaparib.
TolterodineThe metabolism of Tolterodine can be decreased when combined with Olaparib.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Olaparib.
ToremifeneThe metabolism of Toremifene can be decreased when combined with Olaparib.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Olaparib.
TramadolThe metabolism of Tramadol can be decreased when combined with Olaparib.
TrastuzumabTrastuzumab may increase the cardiotoxic activities of Olaparib.
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be decreased when combined with Olaparib.
TrazodoneThe metabolism of Trazodone can be decreased when combined with Olaparib.
TretinoinThe metabolism of Tretinoin can be decreased when combined with Olaparib.
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Olaparib.
TriazolamThe metabolism of Triazolam can be decreased when combined with Olaparib.
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Olaparib.
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Olaparib.
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Olaparib.
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Olaparib.
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Olaparib.
UdenafilThe metabolism of Udenafil can be decreased when combined with Olaparib.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Olaparib.
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Olaparib.
VandetanibThe metabolism of Vandetanib can be decreased when combined with Olaparib.
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Olaparib.
VardenafilThe metabolism of Vardenafil can be decreased when combined with Olaparib.
VemurafenibThe metabolism of Vemurafenib can be decreased when combined with Olaparib.
VenlafaxineThe serum concentration of Olaparib can be increased when it is combined with Venlafaxine.
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Olaparib.
VerapamilThe serum concentration of Olaparib can be increased when it is combined with Verapamil.
VerapamilThe metabolism of Verapamil can be decreased when combined with Olaparib.
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Olaparib.
VilanterolThe metabolism of Vilanterol can be decreased when combined with Olaparib.
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Olaparib.
VinblastineThe metabolism of Vinblastine can be decreased when combined with Olaparib.
VincristineThe metabolism of Vincristine can be decreased when combined with Olaparib.
VindesineThe serum concentration of Vindesine can be increased when it is combined with Olaparib.
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Olaparib.
VismodegibThe metabolism of Vismodegib can be decreased when combined with Olaparib.
VoriconazoleThe serum concentration of Olaparib can be increased when it is combined with Voriconazole.
VoriconazoleThe metabolism of Voriconazole can be decreased when combined with Olaparib.
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Olaparib.
WarfarinThe metabolism of Warfarin can be decreased when combined with Olaparib.
YohimbineThe metabolism of Yohimbine can be decreased when combined with Olaparib.
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Olaparib.
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Olaparib.
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Olaparib.
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Olaparib.
ZileutonThe metabolism of Zileuton can be decreased when combined with Olaparib.
ZiprasidoneThe serum concentration of Olaparib can be increased when it is combined with Ziprasidone.
ZiprasidoneThe metabolism of Ziprasidone can be decreased when combined with Olaparib.
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Olaparib.
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Olaparib.
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Olaparib.
ZopicloneThe metabolism of Zopiclone can be decreased when combined with Olaparib.
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Olaparib.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Zinc ion binding
Specific Function:
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR...
Gene Name:
PARP1
Uniprot ID:
P09874
Molecular Weight:
113082.945 Da
References
  1. Verhagen CV, de Haan R, Hageman F, Oostendorp TP, Carli AL, O'Connor MJ, Jonkers J, Verheij M, van den Brekel MW, Vens C: Extent of radiosensitization by the PARP inhibitor olaparib depends on its dose, the radiation dose and the integrity of the homologous recombination pathway of tumor cells. Radiother Oncol. 2015 Sep;116(3):358-65. doi: 10.1016/j.radonc.2015.03.028. Epub 2015 May 13. [PubMed:25981132 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
Inhibitor
General Function:
Nad+ adp-ribosyltransferase activity
Specific Function:
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.
Gene Name:
PARP2
Uniprot ID:
Q9UGN5
Molecular Weight:
66205.31 Da
References
  1. Verhagen CV, de Haan R, Hageman F, Oostendorp TP, Carli AL, O'Connor MJ, Jonkers J, Verheij M, van den Brekel MW, Vens C: Extent of radiosensitization by the PARP inhibitor olaparib depends on its dose, the radiation dose and the integrity of the homologous recombination pathway of tumor cells. Radiother Oncol. 2015 Sep;116(3):358-65. doi: 10.1016/j.radonc.2015.03.028. Epub 2015 May 13. [PubMed:25981132 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
Inhibitor
General Function:
Nad+ adp-ribosyltransferase activity
Specific Function:
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the ...
Gene Name:
PARP3
Uniprot ID:
Q9Y6F1
Molecular Weight:
60069.7 Da
References
  1. Verhagen CV, de Haan R, Hageman F, Oostendorp TP, Carli AL, O'Connor MJ, Jonkers J, Verheij M, van den Brekel MW, Vens C: Extent of radiosensitization by the PARP inhibitor olaparib depends on its dose, the radiation dose and the integrity of the homologous recombination pathway of tumor cells. Radiother Oncol. 2015 Sep;116(3):358-65. doi: 10.1016/j.radonc.2015.03.028. Epub 2015 May 13. [PubMed:25981132 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Verhagen CV, de Haan R, Hageman F, Oostendorp TP, Carli AL, O'Connor MJ, Jonkers J, Verheij M, van den Brekel MW, Vens C: Extent of radiosensitization by the PARP inhibitor olaparib depends on its dose, the radiation dose and the integrity of the homologous recombination pathway of tumor cells. Radiother Oncol. 2015 Sep;116(3):358-65. doi: 10.1016/j.radonc.2015.03.028. Epub 2015 May 13. [PubMed:25981132 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Verhagen CV, de Haan R, Hageman F, Oostendorp TP, Carli AL, O'Connor MJ, Jonkers J, Verheij M, van den Brekel MW, Vens C: Extent of radiosensitization by the PARP inhibitor olaparib depends on its dose, the radiation dose and the integrity of the homologous recombination pathway of tumor cells. Radiother Oncol. 2015 Sep;116(3):358-65. doi: 10.1016/j.radonc.2015.03.028. Epub 2015 May 13. [PubMed:25981132 ]
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Drug created on May 14, 2015 14:38 / Updated on September 28, 2016 02:28