Cytochrome c oxidase subunit 8A, mitochondrial
Details
- Name
- Cytochrome c oxidase subunit 8A, mitochondrial
- Synonyms
- COX8
- COX8L
- Cytochrome c oxidase polypeptide VIII-liver/heart
- Cytochrome c oxidase subunit 8-2
- Gene Name
- COX8A
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0012781|Cytochrome c oxidase subunit 8A, mitochondrial MSVLTPLLLRGLTGSARRLPVPRAKIHSLPPEGKLGIMELAVGLTSCFVTFLLPAGWILS HLETYRRPE
- Number of residues
- 69
- Molecular Weight
- 7579.0
- Theoretical pI
- 10.83
- GO Classification
- Functionscytochrome-c oxidase activityProcessescellular metabolic process / gene expression / generation of precursor metabolites and energy / hydrogen ion transmembrane transport / mitochondrial electron transport, cytochrome c to oxygen / mitophagy in response to mitochondrial depolarization / positive regulation of defense response to virus by host / respiratory electron transport chain / small molecule metabolic process / transcription initiation from RNA polymerase II promoter / xenophagyComponentsintegral component of membrane / mitochondrial inner membrane / mitochondrial respiratory chain complex IV
- General Function
- Cytochrome-c oxidase activity
- Specific Function
- This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
- Pfam Domain Function
- COX8 (PF02285)
- Transmembrane Regions
- 37-60
- Cellular Location
- Mitochondrion inner membrane
- Gene sequence
>lcl|BSEQ0012782|Cytochrome c oxidase subunit 8A, mitochondrial (COX8A) ATGTCCGTCCTGACGCCGCTGCTGCTGCGGGGCTTGACAGGCTCGGCCCGGCGGCTCCCA GTGCCGCGCGCCAAGATCCATTCGTTGCCGCCGGAGGGGAAGCTTGGGATCATGGAATTG GCCGTTGGGCTTACCTCCTGCTTCGTGACCTTCCTCCTGCCAGCGGGCTGGATCCTGTCA CACCTGGAGACCTACAGGAGGCCAGAGTGA
- Chromosome Location
- 11
- Locus
- 11q12-q13
- External Identifiers
Resource Link UniProtKB ID P10176 UniProtKB Entry Name COX8A_HUMAN GenBank Protein ID 38614453 GenBank Gene ID BC063025 HGNC ID HGNC:2294 - General References
- Rizzuto R, Nakase H, Darras B, Francke U, Fabrizi GM, Mengel T, Walsh F, Kadenbach B, DiMauro S, Schon EA: A gene specifying subunit VIII of human cytochrome c oxidase is localized to chromosome 11 and is expressed in both muscle and non-muscle tissues. J Biol Chem. 1989 Jun 25;264(18):10595-600. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Van Kuilenburg AB, Muijsers AO, Demol H, Dekker HL, Van Beeumen JJ: Human heart cytochrome c oxidase subunit VIII. Purification and determination of the complete amino acid sequence. FEBS Lett. 1988 Nov 21;240(1-2):127-32. [Article]