Gastric intrinsic factor
Details
- Name
- Gastric intrinsic factor
- Synonyms
- IF
- IFMH
- INF
- Intrinsic factor
- Gene Name
- GIF
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0008541|Gastric intrinsic factor MAWFALYLLSLLWATAGTSTQTQSSCSVPSAQEPLVNGIQVLMENSVTSSAYPNPSILIA MNLAGAYNLKAQKLLTYQLMSSDNNDLTIGQLGLTIMALTSSCRDPGDKVSILQRQMENW APSSPNAEASAFYGPSLAILALCQKNSEATLPIAVRFAKTLLANSSPFNVDTGAMATLAL TCMYNKIPVGSEEGYRSLFGQVLKDIVEKISMKIKDNGIIGDIYSTGLAMQALSVTPEPS KKEWNCKKTTDMILNEIKQGKFHNPMSIAQILPSLKGKTYLDVPQVTCSPDHEVQPTLPS NPGPGPTSASNITVIYTINNQLRGVELLFNETINVSVKSGSVLLVVLEEAQRKNPMFKFE TTMTSWGLVVSSINNIAENVNHKTYWQFLSGVTPLNEGVADYIPFNHEHITANFTQY
- Number of residues
- 417
- Molecular Weight
- 45415.67
- Theoretical pI
- Not Available
- GO Classification
- Functionscobalamin bindingProcessescobalamin metabolic process / cobalamin transport / cobalt ion transport / small molecule metabolic process / vitamin metabolic process / water-soluble vitamin metabolic processComponentsapical plasma membrane / endosome / extracellular region / extracellular space / lysosomal lumen / microvillus
- General Function
- Cobalamin binding
- Specific Function
- Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the GIF-cobalamin complex is internalized via receptor-mediated endocytosis.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0017511|Gastric intrinsic factor (GIF) ATGGCCTGGTTTGCCCTCTACCTCCTGAGCCTTCTCTGGGCTACAGCTGGGACTAGTACC CAGACCCAGAGTTCATGCTCCGTTCCCTCAGCACAGGAGCCCTTGGTCAATGGAATACAA GTACTCATGGAGAACTCGGTGACTTCATCAGCCTACCCAAACCCCAGCATCCTGATTGCC ATGAATCTGGCCGGAGCCTACAACTTGAAGGCCCAGAAGCTCCTGACTTACCAGCTCATG TCCAGCGACAACAACGATCTAACCATTGGGCAGCTCGGCCTCACCATCATGGCCCTCACC TCCTCCTGCCGAGACCCTGGGGATAAAGTATCCATTCTACAAAGACAAATGGAGAACTGG GCACCTTCCAGCCCCAACGCTGAAGCATCAGCCTTCTATGGGCCCAGTCTAGCGATCTTG GCACTGTGCCAGAAGAACTCTGAGGCGACCTTGCCGATAGCCGTCCGCTTTGCCAAGACC CTGCTGGCCAACTCCTCTCCCTTCAATGTAGACACAGGAGCAATGGCAACCTTGGCTCTG ACCTGTATGTACAACAAGATCCCTGTAGGTTCAGAGGAAGGTTACAGATCCCTGTTTGGT CAGGTACTAAAGGATATTGTGGAGAAAATCAGCATGAAGATCAAAGATAATGGCATCATT GGAGACATCTACAGTACTGGCCTCGCCATGCAGGCTCTCTCTGTAACACCTGAGCCATCT AAAAAGGAATGGAACTGCAAGAAGACTACGGATATGATACTCAATGAGATTAAGCAGGGG AAATTCCACAACCCCATGTCCATTGCTCAAATCCTCCCTTCCCTGAAAGGCAAGACATAC CTAGATGTGCCCCAGGTCACTTGTAGTCCTGATCATGAGGTACAACCAACTCTACCCAGC AACCCTGGCCCTGGCCCCACCTCTGCATCTAACATCACTGTCATATACACCATAAATAAC CAGCTGAGGGGGGTTGAGCTGCTCTTCAACGAGACCATCAATGTTAGTGTGAAAAGTGGG TCAGTGTTACTTGTTGTCCTAGAGGAAGCACAGCGCAAAAATCCTATGTTCAAATTTGAA ACCACAATGACATCTTGGGGCCTTGTCGTCTCTTCTATCAACAATATCGCGGAAAATGTT AATCACAAGACATACTGGCAGTTTCTTAGTGGTGTAACACCTTTGAATGAAGGGGTTGCT GACTACATACCCTTCAACCACGAGCACATCACAGCCAATTTCACACAGTACTAA
- Chromosome Location
- 11
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P27352 UniProtKB Entry Name IF_HUMAN HGNC ID HGNC:4268 - General References
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