Human chromosome 11 DNA sequence and analysis including novel gene identification.

Article Details

Citation
Copy to clipboard

Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y

Human chromosome 11 DNA sequence and analysis including novel gene identification.

Nature. 2006 Mar 23;440(7083):497-500.

PubMed ID
16554811 [ View in PubMed
]
Abstract

Chromosome 11, although average in size, is one of the most gene- and disease-rich chromosomes in the human genome. Initial gene annotation indicates an average gene density of 11.6 genes per megabase, including 1,524 protein-coding genes, some of which were identified using novel methods, and 765 pseudogenes. One-quarter of the protein-coding genes shows overlap with other genes. Of the 856 olfactory receptor genes in the human genome, more than 40% are located in 28 single- and multi-gene clusters along this chromosome. Out of the 171 disorders currently attributed to the chromosome, 86 remain for which the underlying molecular basis is not yet known, including several mendelian traits, cancer and susceptibility loci. The high-quality data presented here--nearly 134.5 million base pairs representing 99.8% coverage of the euchromatic sequence--provide scientists with a solid foundation for understanding the genetic basis of these disorders and other biological phenomena.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrialP10515Details
B-lymphocyte antigen CD20P11836Details
Acetyl-CoA acetyltransferase, mitochondrialP24752Details
Muscarinic acetylcholine receptor M1P11229Details
NADH dehydrogenase [ubiquinone] 1 subunit C2O95298Details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialO75489Details
Aldehyde dehydrogenase family 3 member B2P48448Details
ATP-binding cassette sub-family C member 8Q09428Details
Transcobalamin-1P20061Details
5-hydroxytryptamine receptor 3AP46098Details
NADP-dependent malic enzyme, mitochondrialQ16798Details
D(4) dopamine receptorP21917Details
L-lactate dehydrogenase A chainP00338Details
Caspase-1P29466Details
Progesterone receptorP06401Details
Glutamate carboxypeptidase 2Q04609Details
Isobutyryl-CoA dehydrogenase, mitochondrialQ9UKU7Details
Tyrosine 3-monooxygenaseP07101Details
Folate receptor gammaP41439Details
Potassium voltage-gated channel subfamily KQT member 1P51787Details
Pyruvate carboxylase, mitochondrialP11498Details
Cysteine--tRNA ligase, cytoplasmicP49589Details
ATP-sensitive inward rectifier potassium channel 11Q14654Details
DNA polymerase alpha subunit BQ14181Details
Choline kinase alphaP35790Details
Glutamate receptor 4P48058Details
Solute carrier family 22 member 11Q9NSA0Details
Excitatory amino acid transporter 2P43004Details
Fatty acid desaturase 1O60427Details
Peroxiredoxin-5, mitochondrialP30044Details
Glycogen phosphorylase, muscle formP11217Details
Sphingomyelin phosphodiesteraseP17405Details
Beta-secretase 1P56817Details
Solute carrier organic anion transporter family member 2B1O94956Details
Solute carrier family 22 member 6Q4U2R8Details
Calcitonin gene-related peptide 1P06881Details
CD44 antigenP16070Details
Metabotropic glutamate receptor 5P41594Details
CatalaseP04040Details
cGMP-inhibited 3',5'-cyclic phosphodiesterase BQ13370Details
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3O94766Details
cGMP-dependent 3',5'-cyclic phosphodiesteraseO00408Details
Bone marrow proteoglycanP13727Details
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3Q96Q83Details
G protein-activated inward rectifier potassium channel 4P48544Details
Glutamine-dependent NAD(+) synthetaseQ6IA69Details
Fatty acid desaturase 2O95864Details
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrialO14521Details
Mitochondrial glutamate carrier 1Q9H936Details
Glycine N-acyltransferaseQ6IB77Details
Glycine N-acyltransferase-like protein 1Q969I3Details
Sodium- and chloride-dependent glycine transporter 2Q9Y345Details
Probable asparagine--tRNA ligase, mitochondrialQ96I59Details
P2Y purinoceptor 2P41231Details
Plasma protease C1 inhibitorP05155Details
Oxidoreductase HTATIP2Q9BUP3Details
N-terminal kinase-like proteinQ96KG9Details
Wee1-like protein kinaseP30291Details
Serine/threonine-protein kinase Chk1O14757Details
Brain-derived neurotrophic factorP23560Details
T-cell surface glycoprotein CD3 delta chainP04234Details
1-aminocyclopropane-1-carboxylate synthase-like protein 1Q96QU6Details
Prostaglandin D2 receptor 2Q9Y5Y4Details
Guanylate cyclase soluble subunit alpha-2P33402Details
Sodium channel subunit beta-4Q8IWT1Details
Solute carrier family 22 member 8Q8TCC7Details
Solute carrier family 22 member 10Q63ZE4Details
Matrix metalloproteinase-20O60882Details
Matrix metalloproteinase-27Q9H306Details
Pannexin-1Q96RD7Details
Steroid hormone receptor ERR1P11474Details
Oxysterols receptor LXR-alphaQ13133Details
Inner centromere proteinQ9NQS7Details
Serine/threonine-protein phosphatase PP1-alpha catalytic subunitP62136Details
Trafficking protein particle complex subunit 4Q9Y296Details
Protein arginine N-methyltransferase 3O60678Details
Potassium voltage-gated channel subfamily A member 4P22459Details
RadixinP35241Details
NAD-dependent protein deacetylase sirtuin-3, mitochondrialQ9NTG7Details
Histone acetyltransferase KAT5Q92993Details
Gastric intrinsic factorP27352Details
Neutral alpha-glucosidase ABQ14697Details
Equilibrative nucleoside transporter 2Q14542Details
Potassium voltage-gated channel subfamily C member 1P48547Details
Solute carrier family 22 member 12Q96S37Details
Serum amyloid A-1 proteinP0DJI8Details
Serine-protein kinase ATMQ13315Details
LayilinQ6UX15Details
Hephaestin-like protein 1Q6MZM0Details
Nucleobindin-2P80303Details
Cation channel sperm-associated protein 1Q8NEC5Details
Diacylglycerol O-acyltransferase 2Q96PD7Details
Stress-induced-phosphoprotein 1P31948Details
Protein RIC-3Q7Z5B4Details
Flap endonuclease 1P39748Details
Apolipoprotein A-IVP06727Details
Amyloid-like protein 2Q06481Details
Splicing factor 1Q15637Details
Sn1-specific diacylglycerol lipase alphaF5GY58Details
Serine/threonine-protein kinase MRCK gammaQ6DT37Details
Homeodomain-interacting protein kinase 3Q9H422Details
Serine/threonine-protein kinase SIK3Q9Y2K2Details
Mitogen-activated protein kinase kinase kinase 11Q16584Details
Mitogen-activated protein kinase kinase kinase kinase 2Q12851Details
Serine/threonine-protein kinase MARK2Q7KZI7Details
Serine/threonine-protein kinase PAK 1Q13153Details
ADP-ribosylation factor-like protein 2P36404Details
Pepsin A-5P0DJD9Details
Solute carrier family 43 member 3Q8NBI5Details
P2X purinoceptor 3P56373Details
Zinc transporter ZIP13Q96H72Details
Diacylglycerol kinase zetaQ13574Details
Caspase-4P49662Details