Y+L amino acid transporter 1
Details
- Name
- Y+L amino acid transporter 1
- Synonyms
- Monocyte amino acid permease 2
- MOP-2
- Solute carrier family 7 member 7
- y(+)L-type amino acid transporter 1
- y+LAT-1
- Y+LAT1
- Gene Name
- SLC7A7
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0008618|Y+L amino acid transporter 1 MVDSTEYEVASQPEVETSPLGDGASPGPEQVKLKKEISLLNGVCLIVGNMIGSGIFVSPK GVLIYSASFGLSLVIWAVGGLFSVFGALCYAELGTTIKKSGASYAYILEAFGGFLAFIRL WTSLLIIEPTSQAIIAITFANYMVQPLFPSCFAPYAASRLLAAACICLLTFINCAYVKWG TLVQDIFTYAKVLALIAVIVAGIVRLGQGASTHFENSFEGSSFAVGDIALALYSALFSYS GWDTLNYVTEEIKNPERNLPLSIGISMPIVTIIYILTNVAYYTVLDMRDILASDAVAVTF ADQIFGIFNWIIPLSVALSCFGGLNASIVAASRLFFVGSREGHLPDAICMIHVERFTPVP SLLFNGIMALIYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYLRWKEPDRPRPLKLSVFF PIVFCLCTIFLVAVPLYSDTINSLIGIAIALSGLPFYFLIIRVPEHKRPLYLRRIVGSAT RYLQVLCMSVAAEMDLEDGGEMPKQRDPKSN
- Number of residues
- 511
- Molecular Weight
- 55990.01
- Theoretical pI
- Not Available
- GO Classification
- Functionsantiporter activity / basic amino acid transmembrane transporter activity / L-amino acid transmembrane transporter activityProcessesamino acid transmembrane transport / amino acid transport / basic amino acid transmembrane transport / blood coagulation / cellular amino acid metabolic process / ion transport / L-alpha-amino acid transmembrane transport / L-amino acid transport / leukocyte migration / protein complex assembly / regulation of arginine metabolic process / transmembrane transport / transportComponentsbasolateral plasma membrane / integral component of plasma membrane / plasma membrane
- General Function
- L-amino acid transmembrane transporter activity
- Specific Function
- Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes.
- Pfam Domain Function
- AA_permease_2 (PF13520)
- Transmembrane Regions
- 37-57 69-89 107-127 133-153 160-180 186-206 222-242 259-279 304-324 383-403 416-436 441-461
- Cellular Location
- Basolateral cell membrane
- Gene sequence
>lcl|BSEQ0021873|Y+L amino acid transporter 1 (SLC7A7) ATGGTTGACAGCACTGAGTATGAAGTGGCCTCCCAGCCTGAGGTGGAAACCTCCCCTTTG GGTGATGGGGCCAGCCCAGGGCCGGAGCAGGTGAAGCTGAAGAAGGAGATCTCACTGCTT AACGGCGTGTGCCTGATTGTGGGGAACATGATCGGCTCGGGCATCTTTGTTTCCCCCAAG GGTGTGCTCATATACAGTGCCTCCTTTGGTCTCTCTCTGGTCATCTGGGCTGTCGGGGGC CTCTTCTCCGTCTTTGGGGCCCTTTGTTATGCGGAACTGGGCACCACCATTAAGAAATCT GGGGCCAGCTATGCCTATATCCTGGAGGCCTTTGGAGGATTCCTTGCTTTCATCAGACTC TGGACCTCCCTGCTCATCATTGAGCCCACCAGCCAGGCCATCATTGCCATCACCTTTGCC AACTACATGGTACAGCCTCTCTTCCCGAGCTGCTTCGCCCCTTATGCTGCCAGCCGCCTG CTGGCTGCTGCCTGCATTTGTCTCTTAACCTTCATTAACTGTGCCTATGTCAAATGGGGA ACCCTGGTACAAGATATTTTCACCTATGCTAAAGTATTGGCACTGATCGCGGTCATCGTT GCAGGCATTGTTAGACTTGGCCAGGGAGCCTCTACTCATTTTGAGAATTCCTTTGAGGGT TCATCATTTGCAGTGGGTGACATTGCCCTGGCACTGTACTCAGCTCTGTTCTCCTACTCA GGCTGGGACACCCTCAACTATGTCACTGAAGAGATCAAGAATCCTGAGAGGAACCTGCCC CTCTCCATTGGCATCTCCATGCCCATTGTCACCATCATCTATATCTTGACCAATGTGGCC TATTATACTGTGCTAGACATGAGAGACATCTTGGCCAGTGATGCTGTTGCTGTGACTTTT GCAGATCAGATATTTGGAATATTTAACTGGATAATTCCACTGTCAGTTGCATTATCCTGT TTTGGTGGCCTCAATGCCTCCATTGTGGCTGCTTCTAGGCTTTTCTTTGTGGGCTCAAGA GAAGGCCATCTCCCTGATGCCATCTGCATGATCCATGTTGAGCGGTTCACACCAGTGCCT TCTCTGCTCTTCAATGGTATCATGGCATTGATCTACTTGTGCGTGGAAGACATCTTCCAG CTCATTAACTACTACAGCTTCAGCTACTGGTTCTTTGTGGGGCTTTCTATTGTGGGTCAG CTTTATCTGCGCTGGAAGGAGCCTGATCGACCTCGTCCCCTCAAGCTCAGCGTTTTCTTC CCGATTGTCTTCTGCCTCTGCACCATCTTCCTGGTGGCTGTTCCACTTTACAGTGATACT ATCAACTCCCTCATCGGCATTGCCATTGCCCTCTCAGGCCTGCCCTTTTACTTCCTCATC ATCAGAGTGCCAGAACATAAGCGACCGCTTTACCTCCGAAGGATCGTGGGGTCTGCCACA AGGTACCTCCAGGTCCTGTGTATGTCAGTTGCTGCAGAAATGGATTTGGAAGATGGAGGA GAGATGCCCAAGCAACGGGATCCCAAATCTAACTAA
- Chromosome Location
- 14
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9UM01 UniProtKB Entry Name YLAT1_HUMAN HGNC ID HGNC:11065 - General References
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