Menaquinone 7
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Menaquinone 7
- DrugBank Accession Number
- DB13075
- Background
Menaquinone 7 is under investigation in clinical trial NCT00402974 (The Effect of Vitamin K Supplementation on Osteocalcin Carboxylation in Healthy Children).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 648.9992
Monoisotopic: 648.490631292 - Chemical Formula
- C46H64O2
- Synonyms
- Menaquinone-7
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareOrlistat Orlistat can cause a decrease in the absorption of Menaquinone 7 resulting in a reduced serum concentration and potentially a decrease in efficacy. - Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Cream Menaquinone 7 (9 g/30g) + Apis mellifera venom (4.5 g/30g) + Glucosamine (6 g/30g) Cream Intra-articular Shantou Youjia E-Commerce Co.,Ltd. 2024-02-01 2024-12-31 US
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as sesquaterpenoids. These are terpenoids with at least 7 consecutive isoprene units.
- Kingdom
- Organic compounds
- Super Class
- Lipids and lipid-like molecules
- Class
- Prenol lipids
- Sub Class
- Sesquaterpenoids
- Direct Parent
- Sesquaterpenoids
- Alternative Parents
- Menaquinones / Naphthoquinones / Quinones / Aryl ketones / Organic oxides / Hydrocarbon derivatives
- Substituents
- Aromatic homopolycyclic compound / Aryl ketone / Benzenoid / Hydrocarbon derivative / Ketone / Menaquinone / Naphthalene / Naphthoquinone / Organic oxide / Organic oxygen compound
- Molecular Framework
- Aromatic homopolycyclic compounds
- External Descriptors
- menaquinone (CHEBI:44245)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 8427BML8NY
- CAS number
- 2124-57-4
- InChI Key
- RAKQPZMEYJZGPI-LJWNYQGCSA-N
- InChI
- InChI=1S/C46H64O2/c1-34(2)18-12-19-35(3)20-13-21-36(4)22-14-23-37(5)24-15-25-38(6)26-16-27-39(7)28-17-29-40(8)32-33-42-41(9)45(47)43-30-10-11-31-44(43)46(42)48/h10-11,18,20,22,24,26,28,30-32H,12-17,19,21,23,25,27,29,33H2,1-9H3/b35-20+,36-22+,37-24+,38-26+,39-28+,40-32+
- IUPAC Name
- 2-[(2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl]-3-methyl-1,4-dihydronaphthalene-1,4-dione
- SMILES
- [H]\C(CC\C(C)=C(/[H])CC\C(C)=C(/[H])CC\C(C)=C(/[H])CC\C(C)=C(/[H])CC\C(C)=C(/[H])CC1=C(C)C(=O)C2=CC=CC=C2C1=O)=C(\C)CCC=C(C)C
References
- General References
- Not Available
- External Links
- PDB Entries
- 1l0v / 1prc / 1r2c / 2b76 / 2jbl / 2prc / 2vpw / 2wjm / 2wjn / 2x5u … show 26 more
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Recruiting Treatment Chronic Kidney Disease (CKD) 1 2 Completed Treatment Calcifications, Vascular / Complication of Hemodialysis / Systemic and Arterial Stiffness / Vitamin K2 Deficiency 1 2 Completed Treatment End Stage Renal Disease (ESRD) 1 Not Available Completed Treatment Healthy Volunteers (HV) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Capsule Oral Cream Intra-articular Solution / drops Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.000229 mg/mL ALOGPS logP 9.58 ALOGPS logP 13.46 Chemaxon logS -6.4 ALOGPS pKa (Strongest Basic) -7.2 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 34.14 Å2 Chemaxon Rotatable Bond Count 20 Chemaxon Refractivity 216.91 m3·mol-1 Chemaxon Polarizability 83.24 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 281.7260206 predictedDarkChem Lite v0.1.0 [M-H]- 269.6231 predictedDeepCCS 1.0 (2019) [M+H]+ 281.1910206 predictedDarkChem Lite v0.1.0 [M+H]+ 271.3842 predictedDeepCCS 1.0 (2019) [M+Na]+ 282.2300206 predictedDarkChem Lite v0.1.0 [M+Na]+ 277.67578 predictedDeepCCS 1.0 (2019)
Drug created at October 21, 2016 02:44 / Updated at September 28, 2021 21:54