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Displaying drugs 101 - 125 of 190 in total

Capromab pendetide

Capromab is a Murine IgG1 monoclonal 7E11-C5.3 antibody that recognizes prostate specific membrane antigen (PSMA – also known as glutamate carboxypeptidase 2) from prostate cancer cells and normal prostate tissue. When linked to pendetide, capromab is used as a chelating agent for the radionuclide Indium In-111 during imaging to evaluate...
Approved
Matched Description: … Capromab is a Murine IgG1 monoclonal 7E11-C5.3 antibody that recognizes prostate specific membrane antigen ... (PSMA – also known as glutamate carboxypeptidase 2) from prostate cancer cells and normal prostate tissue …
Matched Categories: … Indicators and Reagents ... Amino Acids, Peptides, and Proteins …

Besilesomab

Besilesomab is a mouse monoclonal antibody labelled with the radioactive isotope technetium-99m for determining the location of inflammation/infection in peripheral bone in adults with suspected osteomyelitis [FDA Label]. Utilised only as a diagnostic agent, besilesomab is currently approved by the EMEA for marketing and use in various European countries like...
Approved
Matched Description: … Utilised only as a diagnostic agent, besilesomab is currently approved by the EMEA for marketing and ... various European countries like Italy, France, Germany, Spain, Portugal, Norway, Sweden, the Netherlands, and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Tozinameran

The Pfizer-BioNTech COVID-19 vaccine (also known as BNT162b2, Tozinameran, and Comirnaty), is one of four advanced mRNA-based vaccines developed through "Project Lightspeed," a joint program between Pfizer and BioNTech.[L15002,L15007,L36025] Comirnaty is a nucleoside modified mRNA (modRNA) vaccine encoding an optimized full-length version of the severe acute respiratory syndrome coronavirus 2...
Approved
Investigational
Matched Description: … The Pfizer-BioNTech COVID-19 vaccine (also known as BNT162b2, Tozinameran, and Comirnaty), is one of ... advanced mRNA-based vaccines developed through "Project Lightspeed," a joint program between Pfizer and ... [L26956] Fact sheets for caregivers, recipients, and healthcare providers are now available. …
Matched Mixtures name: … Comirnaty Original & Omicron Ba.4/ba.5 ... Comirnaty Original & Omicron Ba.4/ba.5 ... Comirnaty Original & Omicron Ba.4/ba.5 …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Relatlimab

Relatlimab is a human IgG4 monoclonal antibody and novel immune checkpoint inhibitor that targets lymphocyte activation gene-3 (LAG-3).[A246165,L41265] It was the first commercially developed anti-LAG-3 antibody, entering clinical trials in 2013, and has garnered interest in the treatment of a variety of cancers, including leukemia and melanoma. As immune checkpoint...
Approved
Investigational
Matched Description: … Relatlimab is a human IgG4 monoclonal antibody and novel immune checkpoint inhibitor that targets lymphocyte ... combination with other checkpoint inhibitors - for example, PD-1 inhibitors like [nivolumab] or CTLA-4 ... was the first commercially developed anti-LAG-3 antibody, entering clinical trials in 2013,[A246155] and …
Matched Categories: … nivolumab and relatlimab ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …

Lutetium Lu-177 vipivotide tetraxetan

Lutetium Lu-177 vipivotide tetraxetan is a radioligand therapeutic agent. It consists of a radionuclide, lutetium Lu-177, linked to a moiety that binds to PSMA, a transmembrane protein that is expressed in prostate cancer. Lutetium Lu-177 vipivotide tetraxetan was first approved by the FDA on March 23, 2022 as a treatment...
Approved
Matched Iupac: … (177Lu)lutetium(3+) 2-[4,7-bis(carboxylatomethyl)-10-[({[(1r,4r)-4-{[(1S)-1-{[(5S)-5-carboxy-5-({[(1S …
Matched Description: … [L41290] In October 2022, the EMA's Committee for Medicinal Products for Human Use (CHMP) recommended ... tetraxetan was first approved by the FDA on March 23, 2022 as a treatment for prostate-specific membrane antigen–positive …

Fomivirsen

Fomivirsen is a antisense 21 mer phosphorothioate oligonucleotide. It is an antiviral agent that was used in the treatment of cytomegalovirus retinitis (CMV) in immunocompromised patients, including those with AIDS. As a complementary nucleotide to the messenger RNA of the major immediate-early region proteins of human cytomegalovirus, it disrupts the...
Approved
Investigational
Withdrawn
Matched Description: … As a complementary nucleotide to the messenger RNA of the major immediate-early region proteins of human ... drug to be approved by the Food and Drug Administration (FDA). ... _Isis Pharmaceuticals_ and subsequently licensed to _Novartis_ [A31990]. …
Matched Salts cas: … 160369-77-7 …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …

Teplizumab

Teplizumab (teplizumab-mzwv) is a humanized IgG1 kappa CD3-directed monoclonal antibody used to delay the onset of type 1 diabetes (T1D).[A241480,A241045,A241475,L44091] T1D is an autoimmune condition in which T cell-mediated destruction of pancreatic β cells leads to loss of insulin production, impaired glycemic control, and reliance on exogenous insulin. Anti-CD3 therapy...
Approved
Investigational
Matched Description: … [L44091] Fc-receptors can bind to the "tail-end" anti-CD3 antibodies in an antigen-non-specific manner ... and lead to severe adverse effects related to cytokine release syndrome (CRS). ... cell-mediated destruction of pancreatic β cells leads to loss of insulin production, impaired glycemic control, and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Cemiplimab

Cemiplimab is a fully human monoclonal antibody that works against programmed death receptor-1 (PD-1), which is a negative regulator of T cell function. By blocking PD-1, cemiplimab works to enhance T cell-mediated antitumour responses. Cemiplimab was first approved by the FDA on September 28, 2018, as the first FDA-approved treatment...
Approved
Investigational
Matched Description: … [A39201,A254177,L4615] It was later approved to be used in basal cell carcinoma and non-small non-small ... Cemiplimab is a fully human monoclonal antibody that works against programmed death receptor-1 (PD-1) ... [L43872] In October 2022, the EMA's Committee for Medicinal Products for Human Use (CHMP) recommended …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …

Abiraterone

Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 2011, respectively. It is used to treat metastatic...
Approved
Matched Iupac: … 11a-dimethyl-1-(pyridin-3-yl)-3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7- …
Matched Description: … ] and September 2011,[A260880] respectively. ... Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17 ... [L40968, L40193, L47740, L47745] As abiraterone has poor oral bioavailability and is susceptible to …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Hormone Antagonists and Related Agents ... Metabolic Side Effects of Drugs and Substances ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Imlifidase

Chronic kidney disease (CKD) is a progressive and irreversible disease that represents a significant burden for both the individual and healthcare system at large. Currently available treatments for end-stage renal disease are limited to dialysis and renal transplantation, with the former associated with significant costs and lower quality of life.[A225836,A225916]...
Approved
Investigational
Matched Description: … [A225836,A225916] Patients who have developed human leukocyte antigen (HLA) sensitization from prior ... such as CDC and ADCC by cleaving the heavy chains of human immunoglobulin G (IgG) antibodies. ... burden for both the individual and healthcare system at large. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Andusomeran

Andusomeran is a COVID-19 mRNA vaccine developed for use during the 2023-2024 season.[L40074,L48832,L48837] It is similar to previous mRNA vaccines developed by Moderna (e.g. elasomeran, imelasomeran), but is designed to be effective against the Omicron XBB.1.5 subvariant.
Approved

Ocaratuzumab

Ocaratuzumab is a humanized monoclonal antibody directed against CD20. It is being investigated for cancers and autoimmune disorders.
Investigational
Matched Synonyms: … Immunoglobulin G1, anti-(human B-lymphocyte antigen CD20 (B-lymphocyte surface antigen B1, Bp35, leukocyte ... surface antigen Leu-16, membrane-spanning 4-domains subfamily A member 1)) …
Matched Description: … It is being investigated for cancers and autoimmune disorders. …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Tuvirumab

Investigational
Matched Synonyms: … Immunoglobulin g 1 (human monoclonal pe1-1 anti-hepatitis b virus surface antigen), disulfide with human ... Immunoglobulin g 1 (human monoclonal pe1-1 anti-hepatitis b virus surface antigen), disulfide with human ... Immunoglobulin g1, anti-(hepatitis b virus surface antigen) (human monoclonal pe1-1 .gamma.1-chain), …

Lenvervimab

Investigational
Matched Synonyms: … Immunoglobulin g1, anti-(hepatitis b surface antigen) (human monoclonal gc1102 .gamma.1-chain), disulfide ... Recombinant hepatitis B human immunoglobulin ... Hepatitis B virus neutralizing human monoclonal antibody …

Exbivirumab

Exbivirumab is an investigational monoclonal antibody. It is one of the active ingredients in HepeX-B, a drug product containing two human monoclonal antibodies to the hepatitis B virus (HBV) surface antigen.
Investigational
Matched Synonyms: … Immunoglobulin g, anti-(hepatitis b surface antigen) (human monoclonal 19.79.5 heavy chain), disulfide ... with human monoclonal 19.79.5 .lambda. chain, dimer …
Matched Description: … to the hepatitis B virus (HBV) surface antigen. ... It is one of the active ingredients in HepeX-B, a drug product containing two human monoclonal antibodies …

Libivirumab

Libivirumab is an investigational monoclonal antibody. It is one of the active ingredients in HepeX-B, a drug product containing two human monoclonal antibodies to the hepatitis B virus (HBV) surface antigen.
Investigational
Matched Synonyms: … Immunoglobulin g, anti-(hepatitis b surface antigen) (human monoclonal 17.1.41 heavy chain), disulfide ... with human monoclonal 17.1.41 .kappa. …
Matched Description: … to the hepatitis B virus (HBV) surface antigen. ... It is one of the active ingredients in HepeX-B, a drug product containing two human monoclonal antibodies …

Lemzoparlimab

Lemzoparlimab is under investigation in clinical trial NCT04912063 (Study to Evaluate Adverse Events and Movement of Lemzoparlimab in Body When Used Intravenously (IV) With Azacitidine Subcutaneously or IV and Venetoclax Orally in Participants With Acute Myeloid Leukemia and With Azacitidine With or Without Venetoclax in Participants With Myelodysplastic Syndrome).
Investigational
Matched Synonyms: … Immunoglobulin g4(228-proline), anti-(human cd47 antigen) (human monoclonal tj011133 .gamma.4-chain), ... disulfide with human monoclonal tj011133 .kappa. …
Matched Description: … Lemzoparlimab is under investigation in clinical trial NCT04912063 (Study to Evaluate Adverse Events and ... Movement of Lemzoparlimab in Body When Used Intravenously (IV) With Azacitidine Subcutaneously or IV and ... Venetoclax Orally in Participants With Acute Myeloid Leukemia and With Azacitidine With or Without Venetoclax …

Atibuclimab

Atibuclimab (IC14) is a chimeric CD14 antibody investigated for the treatment of patients with severe sepsis.
Investigational
Matched Synonyms: … IMMUNOGLOBULIN G4, ANTI-(HUMAN CD14 ANTIGEN) (HUMAN-MUS MUSCULUS MONOCLONAL IC14 .GAMMA.4-CHAIN), DISULFIDE ... IC14, (RECOMBINANT CHIMERIC MAB AGAINST HUMAN CD14) ... WITH HUMAN-MUS MUSCULUS MONOCLONAL IC14 .KAPPA. …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Ligufalimab

Ligufalimab is a humanized immunoglobulin G4 (IgG4) monoclonal antibody targeting leukocyte surface antigen CD47. It is under investigation in clinical trial NCT04900350 (A Trial of AK117 (Anti-cd47) in Patients With Myelodysplastic Syndrome).
Investigational
Matched Synonyms: … Immunoglobulin g4 (225-proline), anti-(human cd47 antigen) (human-mus musculus monoclonal ak117 .gamma ... .4-chain), disulfide with human-mus musculus monoclonal ak117 .kappa. …
Matched Description: … Ligufalimab is a humanized immunoglobulin G4 (IgG4) monoclonal antibody targeting leukocyte surface antigen …

Otlertuzumab

Otlertuzumab is under investigation in clinical trial NCT01188681 (Safety and Efficacy Study of TRU-016 Plus Bendamustine vs. Bendamustine in Relapsed Chronic Lymphocytic Leukemia).
Investigational
Matched Synonyms: … Immunoglobulin, anti-(human cd antigen cd37) (synthetic human-mus musculus fragment tru-016), dimer …
Matched Description: … Otlertuzumab is under investigation in clinical trial NCT01188681 (Safety and Efficacy Study of TRU-016 …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Zanolimumab

Zanolimumab is a fully human monoclonal antibody directed against CD4.
Investigational
Matched Synonyms: … IMMUNOGLOBULIN, ANTI-(HUMAN CD4 ANTIGEN) (HUMAN MONOCLONAL 6G5 HEAVY CHAIN), DISULPHIDE WITH HUMAN MONOCLONAL …
Matched Description: … Zanolimumab is a fully human monoclonal antibody directed against CD4. …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Asunercept

Asunercept is under investigation in clinical trial NCT02853565 (A Study of CAN008 for Newly Diagnosed Glioblastoma Multiforme).
Investigational
Matched Synonyms: … FAS ANTIGEN (HUMAN EXTRACELLULAR DOMAIN FRAGMENT) FUSION PROTEIN WITH IMMUNOGLOBULIN G1 (HUMAN FC FRAGMENT …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Timolumab

Timolumab is a recombinant, fully-human, IgG4 immunoglobulin with antigen-binding specificity for human vascular adhesion protein-1 (VAP-1).
Investigational
Matched Synonyms: … recombinant, fully-human, IgG4 immunoglobulin with antigen-binding specificity for human vascular adhesion …
Matched Description: … Timolumab is a recombinant, fully-human, IgG4 immunoglobulin with antigen-binding specificity for human …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Seviprotimut-L

Seviprotimut-L is under investigation in clinical trial NCT01546571 (Study of a Melanoma Vaccine in Stage Iib, Iic, and III Melanoma Patients).
Investigational
Matched Synonyms: … Human polyvalent shedded antigen vaccine …
Matched Description: … is under investigation in clinical trial NCT01546571 (Study of a Melanoma Vaccine in Stage Iib, Iic, and …

Covid-19 Coronavirus Artificial Antigen Presenting Cell Vaccine

Through analysis of potential immunogenic targets of the SARS-Cov2 genome, a synthetic ‘minigene’ was developed using domains of viral structural proteins and a polyprotein protease. Specifically, the COVID-19 infection relies on the binding of the Spike protein to an ACEII receptor, and with the described approach, the vaccine uses these...
Investigational
Matched Synonyms: … artificial antigen -Pathogen-specific vaccine …
Matched Name: … Covid-19 Coronavirus Artificial Antigen Presenting Cell Vaccine …
Matched Description: … As of August 2020, this vaccine is being tested for prophylaxis against COVID-19 in human clinical trials ... approach, the vaccine uses these engineered minigenes to express viral proteins, modify artificial antigen ... presenting cells (aAPC), and activate T-cells. …
Displaying drugs 101 - 125 of 190 in total