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Displaying drugs 1901 - 1925 of 1929 in total

XAV-19

XAV-19 is an intravenous antibody-based treatment targeted towards SARS-CoV-2 and other coronaviruses[L16553,L16558]. The therapy concept is based on COVID-19 convalescent plasma. However, rather than using human plasma, XAV-19 is a heterologous swine glyco-humanized polyclonal antibody that targets the spike protein of SARS-CoV-2[L16553,L16558]. The therapy offers three beneficial effects: the ability...
Investigational
Matched Description: … However, rather than using human plasma, XAV-19 is a heterologous swine glyco-humanized polyclonal antibody ... XAV-19 is an intravenous antibody-based treatment targeted towards SARS-CoV-2 and other coronaviruses ... offers three beneficial effects: the ability to neutralize the virus, reduce inflammatory responses, and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Natural Killer Cell

Natural Killer (NK) cells originate and differentiate from hematopoietic stem cells through various signalling pathways involving cytokines and interleukins. These cells arise from CD34+ lymphoid progenitors and comprise 10-15% of all lymphocytes in human peripheral blood. Once completely differentiated, NK cells lack B (CD19-) and T(CD3-) lymphocyte markers and carry...
Investigational
Matched Description: … These cells arise from CD34+ lymphoid progenitors and comprise 10-15% of all lymphocytes in human peripheral ... Induced pluripotent stem cells (iPSCs) and human embryonic stem cells (HESCs) are also used to generate ... Once completely differentiated, NK cells lack B (CD19-) and T(CD3-) lymphocyte markers and carry their …

Genistein

An isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA topoisomerases, type II) activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 phase arrest in human and murine cell lines. Additionally, genistein has antihelmintic activity. It has been...
Investigational
Matched Description: … Experimentally, it has been shown to induce G2 phase arrest in human and murine cell lines. ... It inhibits protein-tyrosine kinase and topoisomerase-II (DNA topoisomerases, type II) activity and is ... used as an antineoplastic and antitumor agent. …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …

Rivabazumab pegol

Rivabazumab pegol is being investigated as a treatment of Pseudomonas aeruginosa lung infections in patients with cystic fibrosis.
Investigational

Phosphatidyl serine

Phosphatidyl serine (PS) is a phospholipid nutrient found in fish, green leafy vegetables, soybeans and rice, and is essential for the normal functioning of neuronal cell membranes and activates Protein kinase C (PKC) which has been shown to be involved in memory function. In apoptosis, phosphatidyl serine is transferred to...
Investigational
Nutraceutical
Matched Description: … rice, and is essential for the normal functioning of neuronal cell membranes and activates Protein kinase ... Phosphatidyl serine (PS) is a phospholipid nutrient found in fish, green leafy vegetables, soybeans and ... PS has been investigated in a small number of double-blind placebo trials and has been shown to increase …

Zoptarelin doxorubicin

Zoptarelin doxorubicin has been used in trials studying the treatment of Breast Cancer, Ovarian Cancer, Prostate Cancer, Endometrial Cancer, and Urothelial Carcinoma, among others.
Investigational
Matched Description: … trials studying the treatment of Breast Cancer, Ovarian Cancer, Prostate Cancer, Endometrial Cancer, and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Abivertinib

Abivertinib is a tyrosine kinase inhibitor targeted against mutant forms of both human epidermal growth factor receptor (EGFR) and Bruton's tyrosine kinase (BTK). It has been investigated for use in the treatment of non-small cell lung cancer (NSCLC) and B-cell malignancies. In binding to and inhibiting EGFR and BTK receptors,...
Investigational
Matched Description: … Abivertinib is a tyrosine kinase inhibitor targeted against mutant forms of both human epidermal growth ... In binding to and inhibiting EGFR and BTK receptors, abivertinib exerts immunomodulatory effects by preventing ... factor receptor (EGFR) and Bruton's tyrosine kinase (BTK). …

COVID19 s-vax loaded autologous dendritic cell vaccine

Dendritic cells (DCs) can be derived and differentiated from peripheral blood mononuclear cells in the presence of specific cytokines and growth factors. These cells are then loaded with antigens produced by a virus or tumor cell and administered as a vaccine. Dendritic Cells (DCs) are showing potential as natural adjuvants...
Investigational
Matched Description: … As of May 2020, the company is pursuing a human clinical trial (ChiCTR2000033003) to test the safety ... and immunogenicity of the vaccine. ... presence of specific cytokines and growth factors. …

CTA018

CTA018 is a member of a new class of vitamin D analogues with a dual mechanism of action, called Vitamin D Signal Amplifiers. This proprietary new drug is both a potent inhibitor of CYP24 (the enzyme responsible for the breakdown of vitamin D) and a potent activator of vitamin D...
Investigational
Matched Description: … Preclinical studies have shown that CTA018 inhibits the proliferation of rapidly dividing cells such as human ... calcipotriol and it is expected to have a greater safety index. ... new drug is both a potent inhibitor of CYP24 (the enzyme responsible for the breakdown of vitamin D) and …

Omega-6 fatty acids

Omega-6 fatty acids are polyunsaturated fatty acids with a final carbon-carbon double bond in the n-6 position, that is, the sixth bond, counting from the methyl end. They are a family of fatty acid molecules that act as precursors to potent lipid mediator signalling molecules with either pro-inflammatory and anti-inflammatory...
Nutraceutical
Matched Description: … molecules that act as precursors to potent lipid mediator signalling molecules with either pro-inflammatory and …

Xylazine

Xylazine is a clonidine analog used as a non-opioid tranquilizer in veterinary medicine and as an emetic, especially in cats.[A9095,L42675,A251420] It acts as an agonist at α2 adrenoceptors; however, its affinity is lower than the one reported for other α2 adrenergic receptor agonists such as detomidine and medetomidine. Xylazine is...
Vet approved
Matched Description: … [A32545] Xylazine is not approved for human use and requires a veterinary licence for its purchase and ... [L42675] Xylazine is sometimes used as an adulterant and combined with opioids and recreational drugs ... [A9096] The use of xylazine can lead to hypotension and bradycardia[A9092,A9093], and when combined with …
Matched Categories: … Hypnotics and Sedatives …

Bavituximab

Bavituximab is a chimeric Anti-PS monoclonal antibody analog which is used to potentially treat cancers and viral infections. It binds to phosphatidylserine and other exposed host cell lipids when induced by cellular stress. Additional analogs in the class include 3G4, 2aG4, 9d2 and Hu3g4.
Investigational
Matched Description: … Additional analogs in the class include 3G4, 2aG4, 9d2 and Hu3g4. ... It binds to phosphatidylserine and other exposed host cell lipids when induced by cellular stress. ... Bavituximab is a chimeric Anti-PS monoclonal antibody analog which is used to potentially treat cancers and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Odronextamab

Odronextamab is a hinge-stabilized, fully human immunoglobulin G4 (IgG4)-based CD20×CD3 bispecific antibody currently evaluated for the treatment of relapsed/refractory (R/R) B-Cell non-Hodgkin lymphoma (NHL).[A254187,A254197] Preliminary studies have shown that in patients with R/R NHL, the use of odronextamab does not lead to the development of neurologic toxicity; however, it can...
Investigational
Matched Description: … Odronextamab is a hinge-stabilized, fully human immunoglobulin G4 (IgG4)-based CD20×CD3 bispecific antibody ... [A254187] In December 2020, the FDA placed a partial clinical hold and requested the drug developer, …

Droloxifene

Droloxifene, a derivative of the triphenylethylene drug tamoxifen, is a novel selective estrogen receptor modulator (SERM). Droloxifene also exhibits more rapid pharmacokinetics, reaching peak concentrations and being eliminated much more rapidly than tamoxifen. Its higher affinity to the estrogen receptor, higher anti-estrogenic to estrogenic ratio, more effective inhibition of cell...
Investigational
Matched Description: … over tamoxifen in the treatment of human breast cancer. ... Droloxifene appears active and tolerable. ... Droloxifene may have an effect on bone and breast tissue because it induces apoptosis. …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …

INO-4800

INO-4800 is a DNA vaccine containing the full sequence for the SARS-CoV-2 Spike (S) protein in development for immunization against COVID-19. Early in vitro studies using HEK-293T cells demonstrated that the transfection of INO-4800 results in the expression of S protein by human cells.[A214475, A214478] Follow up studies in both...
Investigational
Matched Description: … 293T cells demonstrated that the transfection of INO-4800 results in the expression of S protein by human ... of INO-4800 to induce both humoral and T cell-mediated immunity against SARS-CoV-2, including in the ... [A214475, A214478] Follow up studies in both BALB/c mice and Hartley guinea pigs demonstrated the ability …
Matched Categories: … Amino Acids, Peptides, and Proteins …

UB-612

The UB-612 COVID-19 vaccine was developed by United Biomedical Inc Asia in Taipei as the first COVID-19 “multi-tope” protein-peptide vaccine made up of eight rationally designed components . The vaccine incorporates a strong S1-RBD component linked to a single chain fragment region (sFC) of a human IgG1, which facilitates cell...
Investigational
Matched Description: … vaccine incorporates a strong S1-RBD component linked to a single chain fragment region (sFC) of a human ... It was able to reduce viral load and prevent COVID-19 infection in a mouse challenge model and in rhesus ... IgG1, which facilitates cell attachment and acts as the principal neutralizing domain of the virus[L30658 …

Tea tree oil

Tea tree oil is an essential oil derived mainly from the Australian native plant Melaleuca alternifolia via steam distillation of the of the leaves and terminal branches . It may be referred to as Melaleuca alternifolia oil. It has been a popular ingredient in a variety of household and cosmetic...
Experimental
Nutraceutical
Matched Description: … , anti-inflammatory, broad-spectrum antimicrobial and antioxidant properties [A32438]. ... from the Australian native plant _Melaleuca alternifolia_ via steam distillation of the of the leaves and ... It has been a popular ingredient in a variety of household and cosmetic products due to its antiseptic …
Matched Mixtures name: … Muscle and Joint Heat Cream ... Bee Venom Wart And Tags Removal Treatment …

Gantenerumab

Alzheimer's disease (AD) is the most common cause of dementia in elderly patients, with classical histopathological hallmarks including extracellular amyloid-beta (Aβ) plaques and intraneuronal neurofibrillary tangles (NFTs). As the classical view of AD pathology posits that Aβ accumulation triggers tau hyperphosphorylation and aggregation to form NFTs and cause neurodegeneration, large...
Investigational
Matched Description: … [A244705, A244710, A244745] Gantenerumab is a fully human IgG1κ monoclonal antibody derived from the ... Aβ oligomers and fibrils over monomers. ... to reduce Aβ aggregation and remove Aβ plaques. …
Matched Categories: … Amino Acids, Peptides, and Proteins …

NKG2D-ACE2 CAR-NK Cell

These cells are prepared as universal off-the-shelf CAR-NK cells from cord blood with NKG2D-ACE2 proteins engineered as part of the CARs; the cell secretes IL-15 and GM-CSF. Chimeric antigen receptors (CARs) are artificial receptors consisting of an antibody-derived antigen binding domain and transmembrane and signaling domains from T-cell receptor signalling...
Investigational
Matched Description: … First used with autologous human T cells (CAR-T) as cancer immunotherapies, these receptors are now being ... The transmembrane NKG2D and intracellular 2B4 domains are required for optimal NK signalling and subsequent ... transmembrane and signaling domains from T-cell receptor signalling moieties. …

Nonivamide

Nonivamide is found in herbs and spices. It is an alkaloid from the Capsicum species. The structures of DB06774 and nonivamide differ only slightly with respect to the fatty acid moiety of the side chain (8-methyl nonenoic acid versus nonanoic acid) . Nonivamide is a flavoring ingredient. Nonivamide is an...
Investigational
Matched Description: … Nonivamide is an organic compound and a capsaicinoid. ... It is an amide of pelargonic acid and _vanillylamine_. ... Nonivamide is found in herbs and spices. It is an alkaloid from the Capsicum species. …

Calcium

Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the...
Nutraceutical
Matched Description: … Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, ... Calcium gluconate and calcium lactate are absorbed well by pregnant women. ... Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. …
Matched Mixtures name: … Hvp Chelated Cal/mag With Zinc and Vitamins C and D ... CALCIUM AND MAGNESIUM PLUS C,POTASSIUM AND ZINC TABLET ... Calci A and D Tab …
Matched Categories: … Antacids and Adsorbents ... Alimentary Tract and Metabolism ... multivitamins and calcium ... ascorbic acid (vit C) and calcium ... Calcium-Regulating Hormones and Agents …

Ezatiostat

Ezatiostat is investigated in clinical trials for treating myelodysplastic syndrome. This compound belongs to the peptides. These are compounds containing an amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen...
Investigational
Matched Description: … Ezatiostat has myelostimulant activity in preclinical rodent models and human bone marrow cultures, and ... differentiates granulocytes and monocytes in HL60 cells. ... monocytes (white blood cells), erythrocytes (red blood cells) and platelets. …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Umbilical Cord Blood Hematopoietic Stem Cells

The use of umbilical cord blood (UCB) for therapies is advantageous because of its ease of access, non-invasive collection procedures, and more plasticity for multi-differentiation. UCB contains a large source of hematopoietic stem cells (HSCs) that are capable of self-renewal, have increased sensitivity to various factors, and are able to...
Investigational
Matched Description: … Specifically, the proliferation capacity of human umbilical cord blood mononuclear progenitor cells ( ... From the UCB, mononuclear cells are isolated and cultured in medium, expanded, and differentiated into ... of cytotoxicity and immunological reactions. …

Curcuma xanthorrhiza oil

Curcuma xanthorrhiza oil is extracted from Curcuma xanthorrhiza Roxb., a member of the ginger family (Zingiberaceae) that is widely distributed in the region of Southeastern Asia . Curcuma xanthorrhiza is also known as Javanese Turmeric or Temoe Lawak . For centuries, Curcuma xanthorrhiza oil has been used as a traditional...
Nutraceutical
Matched Description: … Curcumin is a mixture of dicinnamoylmethane derivatives and other phenolic and non-phenolic diarylheptanoids ... _Curcuma xanthorrhiza_ oil is found as an active ingredient in cosmetic and hygienic products, and marketing ... sesquiterpenes, 44.5% of xanthorrhizol, and a small amount of [DB01744] [F114]. …

Isoflavone

Isoflavone is a soy phytoestrogen and a biologically active component of several agriculturally important legumes such as soy, peanut, green peas, chick peas and alfalfa . Soybean is an exceptionally rich source of dietary isoflavones, where the average isoflavone content is 1-2 mg/gram . The main soy isoflavones are mostly...
Experimental
Matched Description: … The main soy isoflavones are mostly present in glycosylated forms and include [DB01645], [DB13182], and ... breast and prostate cancer [A33099]. ... legumes such as soy, peanut, green peas, chick peas and alfalfa [A33103]. …
Displaying drugs 1901 - 1925 of 1929 in total