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Identification
NameCalcium
Accession NumberDB01373
TypeSmall Molecule
GroupsNutraceutical
Description

Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium. Low calcium intake may also be a risk factor in the development of osteoporosis. The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. Calcium gluconate and calcium lactate are absorbed well by pregnant women. Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast.

Structure
Thumb
SynonymsNot Available
External Identifiers Not Available
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Alka-cal Tabletstablet166.6 mgoralMorter HealthsystemNot applicableNot applicableCanada
Leucovorin Ca Inj (pharm. Bulk Vial) 10mg/mlliquid10 mgintravenousDavid Bull Laboratories (Pty) Ltd.1992-12-311997-08-14Canada
Pharmacal 500 Tab 500mgtablet500 mgPharmadex Laboratories Inc.1993-12-311999-08-28Canada
Generic Prescription ProductsNot Available
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
7030 Calcium Goldcapsule.99 1/1oralApexel Co., Ltd2013-03-102016-04-05Us
7030 Calcium Premiumcapsule.99 1/1oralApexel Co., Ltd2013-03-102016-04-05Us
Bakanasan Calcium Citrate Powderpowder63.4 mgoralRheingold Food International Ltd.1995-12-311999-08-03Canada
Biocalth Calcium Powderpowder336 mgoralBiocalth International Corporation2003-05-102006-07-31Canada
Biocalth Calcium Supplementtablet100 mgoralBiocalth International Corporation2002-10-152006-07-31Canada
Bodysmarts With Calciumtablet30 mgoralCadbury Adams Canada Inc.2001-02-192005-07-28Canada
Cal 500 Tab 500mgtablet500 mgoralBioforce Canada Inc.1985-12-311997-04-04Canada
Cal Gel Cap 45mgcapsule45 mgoralLaboratoire Lalco Inc.1977-12-311997-07-31Canada
Cal Supp 500tablet500 mgoralWn Pharmaceuticals Ltd.2002-06-062006-08-08Canada
Cal Supp 500 - Tabtablet500 mgoralVita Health Products Inc1996-10-112008-08-05Canada
Cal-citrustablet200 mgoralSterimax Inc1996-09-102006-10-20Canada
Calciumtablet500 mgoralHealth Wise Nutrition Inc.2000-04-042002-07-18Canada
Calciumcapsule150 mgoralSeroyal International Inc.1996-12-312009-07-06Canada
Calcium 350 Mg (calcium Citrate) - Caplettablet350 mgoralVita Health Products Inc1996-10-112007-07-30Canada
Calcium 350 Mg (calcium Citrate) Caplettablet350 mgoralPurity Life Health Products A Division Of Sunopta Inc.2002-06-012008-07-07Canada
Calcium 350mgtablet350 mgoralGeneral Nutrition Canada Inc.2001-10-202009-08-05Canada
Calcium 500 mgtablet500 mgoralNutricorp International2001-11-012007-08-01Canada
Calcium 600tablet600 mgoralLaboratoire Riva Inc2001-01-152008-08-11Canada
Calcium 600mg Dietary Supplementtablet600 mgoralGarden State Nutritionals1998-08-312000-06-07Canada
Calcium 650mgtablet650 mgoralNutricorp International1999-12-152007-08-01Canada
Calcium 650mg Tabtablet650 mgoralJamieson Laboratories Ltd1994-12-312006-07-25Canada
Calcium Caps 400mgcapsule400 mgoralTwin Laboratories Inc.1995-12-311999-11-10Canada
Calcium Carbonatetablet500 mgoralVita Health Products Inc1985-12-312004-07-26Canada
Calcium Carbonate 1500mgtablet600 mgoralWn Pharmaceuticals Ltd.2002-05-312007-08-07Canada
Calcium Carbonate Tabtablet246 mgoralSwiss Herbal Remedies Ltd.1989-12-311998-07-15Canada
Calcium Citramatecapsule160.0 mgoralThorne Research Inc.1997-04-182006-08-04Canada
Calcium Citratetablet350 mgoralHolista Health (Canada) Inc.2002-11-132008-07-17Canada
Calcium Citratetablet200 mgoralVita Health Products Inc1998-01-132004-07-26Canada
Calcium Citrate 300mgtablet300 mgoralWn Pharmaceuticals Ltd.1998-06-192008-07-17Canada
Calcium Gluconate Tablets USP 650 mgtablet60 mgoralPharmetics (2011) Inc2002-03-102006-07-27Canada
Calcium Lactate 650mgtablet120 mgoralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Calcium Lactate Capscapsule100 mgoralTwin Laboratories Inc.1995-12-311999-11-10Canada
Calcium Lactate Tab 84.5mgtablet84.5 mgoralLaboratoire Lalco Inc.1980-12-311997-07-31Canada
Calcium Lactate Tablets USP 650 mgtablet84 mgoralPharmetics (2011) Inc2002-03-102006-07-27Canada
Calcium Liquidliquid100 mgoralPharmetics (2011) Inc2002-09-302009-07-30Canada
Calcium Liquid Syrupsyrup100 mgoralSupplements Aromatik Inc.2003-07-022008-08-01Canada
Calcium Sandoz Syr 110mg/5mlsyrup110 mgoralNovartis Consumer Health Canada Inc.1995-12-311999-07-21Canada
Calcium Syrup 110mg/5mlsyrup110 mgoralVita Health Products Inc1990-12-312002-07-31Canada
Calsan Chewable Tab 500mgtablet500 mgoralNovartis Consumer Health Canada Inc.1986-01-012008-07-15Canada
Chelated Calcium Supplement - 150mg Tabtablet150 mgoralAlbion Laboratories Inc.1996-09-062002-07-12Canada
Chelazome Calcium 125mgtablet125 mgoralTrophic Canada Ltd.1987-12-312000-08-03Canada
Children's Chewable Calcium (chewable Tablets)tablet266.7 mgoralGeneral Nutrition Canada Inc.1998-11-232007-08-01Canada
Coral Calciumpowder216.7 mgoralNature's Sunshine Products Of Canada Ltd.2003-12-012007-07-30Canada
Dia Cal Cap 500mgcapsule500 mgoralR & D Laboratories Inc.1991-12-312003-07-16Canada
Ena Actimineral Aliquid803.8 mg/1000mLoralJinju Bio Food2013-06-282016-04-05Us
Extra Strength Calcium Antacid Chewabletablet300 mgoralPerrigo International1996-12-311998-08-12Canada
Gellucal Cap 45mgcapsule45 mgoralVitalab1990-12-311996-09-09Canada
Hantai 8030 Ca-D3 Goldtablet.99 1/1oralApexel Co., Ltd.2015-05-182016-04-05Us
Hantai 8030 Ca-D3 Premiumtablet.99 1/1oralApexel Co., Ltd.2015-05-182016-04-05Us
Hi Potency Cal Tab 650mgtablet650 mgoralSwiss Herbal Remedies Ltd.1986-12-311997-07-28Canada
Lactate De Calcium 648 mgtablet84.2 mgoralGamme Nature1990-12-312008-07-31Canada
Lactate De Calcium Tab 42.1mgtablet42.1 mgoralLe Naturiste J.M.B. Inc.1980-12-311997-07-23Canada
Mor-cal Tab 500mgtablet500 mgoralPharmetics (2011) Inc1986-12-312006-07-27Canada
Nutrol-cal Tab 875mgtablet350 mgoralRolmex International Inc.1990-12-311997-08-08Canada
Os-cal 250 mgtablet250 mgoralWyeth Canada1994-12-312003-07-28Canada
Os-cal 500tablet500 mgoralWyeth Canada1993-12-312008-12-16Canada
Os-cal 500 Chewable Tab 500mgtablet500 mgoralWyeth Ayerst Canada Inc.1996-09-301998-01-28Canada
Os-cal 500 Chewable Tab 500mgtablet500 mgoralAyerst Laboratories1986-12-311997-08-15Canada
Prevencal Tab 500mgtablet500 mgoralLaboratoire Lalco Inc.1988-12-311997-07-31Canada
Regular Strength Calcium Antacid Chew. Tabstablet200 mgoralPerrigo International1996-12-311998-08-12Canada
Soluble Calcium Citrate 1200mgtablet250 mgoralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Tropicana Calcium Supplement 344 mgsolution1.458 mgoralTropicana Canada2002-01-142007-06-21Canada
Tropicana Calcium Supplement 393 mgsolution1.667 mgoralTropicana Canada2002-02-182007-06-21Canada
Tropicana Calcium Supplement 604 mgsolution1.458 mgoralTropicana Canada2003-02-072007-06-21Canada
Tums 500 Tabtablet500 mgoralSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.1994-12-311996-09-12Canada
Tums Extra Strength Assorted Tropical Fruittablet300 mgoralSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.1996-09-101998-08-25Canada
Tums Ultra Strength Assorted Mint Flavourstablet400 mgoralSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.1996-12-311998-08-25Canada
Tums Ultra Strength Assorted Tropical Fruittablet400 mgoralSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.1997-07-311998-08-25Canada
Tums Ultra Strength Liquidliquid400 mgoralSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.1997-04-172001-07-31Canada
Vitamine C Cap 600mgcapsule600 mgoralSisu Inc.1989-12-312008-07-25Canada
Webber Calcium Tab 500mgtablet500 mgoralNovartis Consumer Health Canada Inc.1985-12-311998-07-08Canada
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
A D Calcium TabStar Products Inc.
A-D Calcium CapVitalab
A.R.T.H. Away FormulaAbundance Marketing Ltd.
Act EtidrocalActavis Pharma Company
Acti-cal/mag 2:1 + Zinc and D CapletActi Form Ltd.
Acti-megascorb Crystals PwrActi Form Ltd.
Actonel Plus CalciumWarner Chilcott Canada Co
Actonel Sachet KitWarner Chilcott Canada Co
Ad & Calcium CapLaboratoire Lalco Inc.
Ad Calcium CapLes Produits Gerbex Inc.
Alsimine W Vitamins A DAlsi Cie Ltee
Astral C TabAlbi Naturals
Avon Nutrivance Soft Calcium Chews With Vitamin DAvon Canada Ulc
B & J Formula Dietary SupplementGarden State Nutritionals
B-nexaUpsher Smith Laboratories, Inc.
BaisixProdemdis Enr.
BseltzerAbundance Marketing Ltd.
Buffered Vitamin C Powder With Ca Mg and KThorne Research Canada Ltd.
Buffered Vitamin C Pwr W Cal-mag-potassiumSisu Inc.
C-crystals With CalciumAlive Vitamins
Cal & Mag Hvp Chel Plus C Potass & Zinc TabGahler Enterprises Ltd.
Cal M TabAnabolic Laboratories Inc.
Cal Mag Drink With Vitamin CWampole Brands
Cal Mag Plus - TabNutrilite, A Division Of Access Business Group, Llc
Cal Mag TabSwiss Herbal Remedies Ltd.
Cal-mag (one To One) With Potass & ZincGahler Enterprises Ltd.
Cal-mag Citrate Zinc & Vitamin D TabletsSwiss Herbal Remedies Ltd.
Cal-mag Complete With Zinc, C and DQuest Vitamins A Div Of Purity Life Health Products
Cal-mag Plus K, Mn and Zn CapletsHealth Wise Nutrition Inc.
Cal-mag TabletStandard Process Inc.
Cal-mag Vitamin C and Zinc TabSwiss Herbal Remedies Ltd.
Cal-mag With Vitamin DAlbi Imports Ltd.
Cal-mag With Zinc & Vitamin DHealth Wise Nutrition Inc.
Cal/mag 1:1 With Zinc and Vitamin D - TabletHealth Wise Nutrition Inc.
Cal/mag 2:1 With DWn Pharmaceuticals Ltd.
Cal/mag+dSeroyal International Inc.
Calburst Calcium 500mg With Vitamin DPharmavite Llc
Calci-yum Plus Magnesium + D3Nu Life Nutrition Ltd.
Calcimag TabLes Produits Naturels Suisse Inc.
CalcitolFrega Inc.
Calcium Mg and Zn Capsules With Vitamin DRheingold Food International Ltd.
Calcium & Magnesium Citrate Plus D With Manganese, Potassium & ZincNatural Factors Nutritional Products Ltd.
Calcium & Magnesium Plus Potassium & ZincNatural Factors Nutritional Products Ltd.
Calcium & Magnesium Plus Potassium, Zinc, & ManganeseNatural Factors Nutritional Products Ltd.
Calcium & Magnesium TabBioforce Canada Inc.
Calcium & Magnesium TabletsVita Health Products Inc
Calcium & Magnesium With Potassium & ZincWn Pharmaceuticals Ltd.
Calcium & Magnesium With Potassium, Zinc, Manganese & Vitamin DWn Pharmaceuticals Ltd.
Calcium & Magnesium With Vitamin DOrganika Health Products Inc.
Calcium & Vitamin DQuantofill Inc.
Calcium 250 Mg With Vitamin DGfr Pharma Ltd.
Calcium 400 With Magnesium - PwrHillestad Pharmaceuticals Usa
Calcium 500 With Vitamin D TabVita Health Products Inc
Calcium 500mg With Vitamin DNutricorp International
Calcium 600 + DLaboratoire Riva Inc
Calcium 600 + D ComprimesNobel Pharm Enr.
Calcium 600mg + Vit D3 125unit TabPharmetics (2011) Inc
Calcium 650mg With Vitamin DNutricorp International
Calcium A DProduits Phyto Inc.
Calcium and Mag-potass and Zinc CapGahler Enterprises Ltd.
Calcium and Magnesium 1:1 Plus TabletsAlbi Naturals
Calcium and Magnesium Citrate and Vitamin D 250mg/125mg/200iuWn Pharmaceuticals Ltd.
Calcium and Magnesium Citrate With Vitamin DSisu Inc.
Calcium and Magnesium TabAlbi Imports Ltd.
Calcium and Magnesium TabletsVitazan Herbs & Vitamins Inc.
Calcium and Magnesium W Zinc TabPharmavite Llc
Calcium and Magnesium With Vitamin DVita Health Products Inc
Calcium and Magnesium With ZincVita Health Products Inc
Calcium and Vitamin D - Soft ChewVita Health Products Inc
Calcium Ascorbate 1000 Mg - TabletHealth Wise Nutrition Inc.
Calcium Ascorbate Cap 850mgQuest Vitamins A Div Of Purity Life Health Products
Calcium Ascorbate PowderEster C Health Co, Division Of Inter Cal Corp
Calcium Ascorbate Tab 550mgEster C Health Co, Division Of Inter Cal Corp
Calcium Caps Plus MagnesiumTwin Laboratories Inc.
Calcium Capsules With Magnesium and Vitamin DHerba Lab Inc.
Calcium Carbonate + Vitamin DWn Pharmaceuticals Ltd.
Calcium Carbonate Tablets With Vitamin DVita Health Products Inc
Calcium Chelate Plus Vit DHall Laboratories, Ltd.
Calcium Citrate and Vitamin D 200mg/160iuWn Pharmaceuticals Ltd.
Calcium Citrate With Vitamin DWn Pharmaceuticals Ltd.
Calcium Et Magnesium Plus Vitamin DLaboratoire Lalco Inc.
Calcium Et Magnesium Plus Vitamine D/fe/znLaboratoire Lalco Inc.
Calcium Et Magnesium TabLaboratoire Lalco Inc.
Calcium Lactate PowderStandard Process Inc.
Calcium Magnesium 1000/500 - TabPro Shop Inc.
Calcium Magnesium 2:1 Tablets With Vitamin DSisu Inc.
Calcium Magnesium Avec Vitamine CLes Aliments Nutri Source Inc.
Calcium Magnesium Avec Vitamine D Et ZincLes Aliments Nutri Source Inc.
Calcium Magnesium TabNutricorp International
Calcium Magnesium Tablets Nu LifeNu Life Nutrition Ltd.
Calcium Magnesium With Potassium TabNutrition For Life International
Calcium PlusLaboratoire Riva Inc
Calcium Tab W Vit DShoppers Drug Mart Inc.
Calcium With Magnesium and Vitamin DGeneral Nutrition Canada Inc.
Calcium With Mg Zn Mn Cu CR Si and Vit. C & DJamieson Laboratories Ltd
Calcium With Vitamin D 200 Mg/160 IuWn Pharmaceuticals Ltd.
Calcium With Vitamin D2Sisu Inc.
Calcium With Vitamins C and D TabPure Life International Prods Inc.
Calcium-magnesium Cap 1:1 W Vitamin DSisu Inc.
Calcium-magnesium With K & Zn and Vitamin D3Holista Health (Canada) Inc.
Calcium, Magnesium, Zinc and DNutravite Pharmaceuticals Inc.
Calcium/magnesium DrinkNew Vision Nutritionals Company
Calcium/magnesium Supplement TabletsGeneral Nutrition Canada Inc.
Calcium/magnesium/vitamin D - CapsuleHolista Health (Canada) Inc.
CalcorSimone Protective Pharmaceuticals, Inc.
Calma-DWn Pharmaceuticals Ltd.
CalmaxMedia Power, Inc.
CalplusLifestyles Canada Corporation
Caltrate 600 Plus D - TabletWhitehall Robins Inc.
Cell-wiseMelaleuca Of Canada Inc.
Cell-wise Natural SourceMelaleuca Of Canada Inc.
Chela Calmag-100 Plus Zinc D3Nu Life Nutrition Ltd.
Chela Calmag-300 Plus Zinc D3Nu Life Nutrition Ltd.
Chelated Cal-mag(2:1)with Zn Vit.c and DHealth Wise Nutrition Inc.
Chelated Cal/mag/zn With VitaminsHealth Wise Nutrition Inc.
Chelated Calcium and Magnesium TabAlive Vitamins
Chewable Cal-mag Chocolate FlavourViva Life Science, Inc.
Chewable Calcium & Magnesium 2:1 TabletSwiss Herbal Remedies Ltd.
Chewable Calcium 500 Mg With Vitamin D 200 IuVita Health Products Inc
Chewable Calcium Plus Magnesium and MineralsNature's Sunshine Products Of Canada Ltd.
Citrate De Calcium Plus Vitamine D Et ZincSantÉ Naturelle (Ag) LtÉe
Coral Calcium Plus Vitamin DHolista Health (Canada) Inc.
Coral Calcium Plus Vitamin D 210mg/100iuWn Pharmaceuticals Ltd.
DidrocalWarner Chilcott Canada Co
Dol Mite TabSwiss Herbal Remedies Ltd.
Dolomite 1280mgRay Irastorza
Eden With Calcium and Vitamin DWarner Lambert Canada Inc.
Efferlife Calcium 500mg + Vitamin D3 440 Iu + Vitamin C 125mgNaturale Science Inc.
Effervescent Vitamin C Powder With Ca and mgThorne Research Canada Ltd.
Enviroflex - TabEnviro Tech International Canada
Ester C 500 TabNu Life Nutrition Ltd.
Ester C Calcium Ascorbate CapNatrol, Inc.
Ester C CapsuleNatural Factors Nutritional Products Ltd.
Ester C PowderNatural Factors Nutritional Products Ltd.
Ester C Tab ChewableNatrol, Inc.
Ester C Vitamin C and Calcium PwsNatrol, Inc.
Ester-CNatural Factors Nutritional Products Ltd.
Ester-C 500 mgWn Pharmaceuticals Ltd.
Ester-C 600 mgWn Pharmaceuticals Ltd.
Ester-C 787mgNatural Factors Nutritional Products Ltd.
Ester-C Calcium Ascor TabNatrol, Inc.
Ester-C Calcium Ascorbate CapsulesSwiss Herbal Remedies Ltd.
Ester-C Calcium Ascorbate TabNatrol, Inc.
Ester-C Calcium Ascorbate TabletsSwiss Herbal Remedies Ltd.
Ester-C PowderNatural Factors Nutritional Products Ltd.
Ester-C TabletNatural Factors Nutritional Products Ltd.
Ester-C Vitamin C With CalciumDarwen Holdings Ltd.
EtidrocalSanis Health Inc
FemidausePns Pharma Therapy
Feminique W Iron and Calcium TabStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Ferrous SulfateMartin Ekwealor Pharmaceuticals, Inc.
Flex CapsulesFoodscience Laboratories, Division Of Foodscience Corporation
Folcaps Omega-3Midlothian Laboratories
Formula 2025 TabStandard Process Inc.
Formula 9 TabPure Life International Prods Inc.
Formula A.R.-th Dietary SupplementRx Vitamins Inc.
Formula InfBalance Plus, Inc.
Formula IntBalance Plus, Inc.
Formula O-care Vitamin and Mineral SupplementFor Mor International Inc.
Fusion Activator Formula TabL & S Research Corporation
Fusion PM Formula TabL & S Research Corporation
Good Night/pm Formula TabNikken Usa, Incorporated
Hemarexin TabLab Bio Chimique Inc.,Division Of Technilab Pharma Inc.
Hormodausse Plus Calc Et D TabLaboratoires Charton Laboratories
Hvp Chelated Cal/mag With Zinc and Vitamins C and DDarwen Holdings Ltd.
Hypo Vites TabPharmetics (2011) Inc
IpricalPep Products Inc.
Isotonix Calcium Plus FormulaMarket America, Inc.
Kanga-V Multivitamins & MineralsLacombe Drugs (1992) Ltd
Liqui Cal-DTwin Laboratories Inc.
LiquicalLand Art Inc.
Liquid Cal-magSeroyal International Inc.
Liquid Cal/mag Plus DGahler Enterprises Ltd.
Liquid Calcium and Magnesium With Vit.dRheingold Food International Ltd.
Liquid Calcium With Vitamin DT & T Nutrition Inc.
Lysamine Diet Supp Amp-tabWelcker Lyster Ltd., Division Of Technilab Inc.
Mag/cal 1:1 Capsules W Vitamin DRheingold Food International Ltd.
MagnacalHolista Health (Canada) Inc.
Menocal TabLes Aliments Nutri Source Inc.
Mid-life Magnacal 2Holista Health (Canada) Inc.
Min-tran TabStandard Process Inc.
Mnps Formula SupplementGarden State Nutritionals
Mor-vites TabPharmetics (2011) Inc
Multi RolRolmex International Inc.
Multi Vitamin-mineral FormulaVita Health Products Inc
Multi-min Electro C Pow Plus B2Quest Vitamins A Div Of Purity Life Health Products
Multimineral ChelatesW.R. Enterprises Inc.
Multiple Vitamin Plus Minerals TabHall Laboratories, Ltd.
Multiple Vitamins and Minerals TabRandle Labs Inc.
Multiple Vitamins With Minerals TabletsPharmetics (2011) Inc
Multivitamines Et MinerauxLe Groupe M. Vachon Inc.
Mylan-eti-cal CarepacMylan Pharmaceuticals Ulc
Nata KompleteWh Nutritionals, Llc
Natelle OneMEDA Pharmaceuticals
Nexa PlusUpsher Smith Laboratories, Inc.
Nexa Select Rx Prenatal Vitamin With Plant-based DHAUpsher Smith Laboratories, Inc.
Novo-etidronatecalTeva Canada Limited
Ntp-etidronate CalciumTeva Canada Limited
Nutravite Calcium Magnesium and Zinc CapsNutravite Pharmaceuticals Inc.
Nutri-chem Cal MagNutri Chem Pharmacy Ltd
Nutri-chem Calcium Magnesium With D and ZincNutri Chem Pharmacy Ltd
O Calcium 500mg Plus D TabVita Health Products Inc
O-cal Prenatal VitaminPharmics, Inc.
O-calcium 250mg Plus DVita Health Products Inc
One A Day Advance AdultsBayer Inc Consumer Care
One A Day Advance Adults 50+Bayer Inc Consumer Care
One A Day Advance FemBayer Inc Consumer Care
One A Day Bone BuilderBayer Inc Consumer Care
One A Day TabCountry Health Laboratories Ltd.
Opti-cal Chewable +d CapletNu Life Nutrition Ltd.
Orange Flavored Crystal Chews TabJeunique International Inc.
Orifer FSanofi Aventis Canada Inc
Os-cal-D 500Wyeth Canada
Osteo FormulaNutramed Laboratories Inc.
Osteo-lifeViva Pharmaceutical Inc.
Osteo-plusRolmex International Inc.
Osteocit-DSeaford Pharmaceuticals Inc
OsteoligoClinique Lafontaine Inc, Division Les Importations Ortho
Oyster Shell Calcium With Vitamin DCardinal Health
Phytofortis + Calcium A-DProduits Phyto Inc.
PMS-risedronate Plus CalciumPharmascience Inc
Pnv-dhaAcella Pharmaceuticals, LLC
Port A Mins Super Cal-mag 300/150 With Vitamin D3Great Earth Companies, Inc.
Port A Mins Super Cal-mag 600/300Great Earth Companies, Inc.
Port A Mins Super Calcium 375 With Vitamin D3Great Earth Companies, Inc.
Port A Mins Super Calcium 750 With Vitamin D3Great Earth Companies, Inc.
Pour Ma SantéProdemdis Enr.
PregvitDuchesnay Inc
Pregvit Folic 4Duchesnay Inc
Pregvit Folic 5Duchesnay Inc
PremelLe Naturiste J.M.B. Inc.
Prenatal Vitamins Plusbryant ranch prepack
Prenavite Forte TabletsRoberts Pharmaceutical Canada Inc.
Prenavite TabletsRoberts Pharmaceutical Canada Inc.
Prevencal + D A Croquer 600mgLaboratoire Lalco Inc.
Prevencal 300 + D A CroquerLaboratoire Lalco Inc.
Prevencal 500 +dLaboratoire Lalco Inc.
Prevencal 600 + D Et FerLaboratoire Lalco Inc.
Prevencal 600 + D Et MagnesiumLaboratoire Lalco Inc.
Pure Calcium CalciumSaimdang Cosmetics Co., Ltd
Redoxon-calBayer Inc Consumer Care
ReebokClearly Canadian Beverage Corporation
Revitex Ampoules Et ComprimesLes Produits Gerbex Inc.
Revival 1 TabBio Vita
Rolaids Extra Strength Multi-symptom TabletsSanofi Consumer Health Inc Sanofi Sante Grand Public Inc
Rolaids Extra Strength TabWarner Lambert Canada Inc.
Silica-calcium With Biotin CapsulesNaka Sales Ltd.
Somarexin and C 1000Laboratoire Lalco Inc.
Super C Crystals W CalciumNu Life Nutrition Ltd.
Super C-M-KCreative Nutrition Canada Corp.
Super Cal Mag PlusShaklee Canada Inc
Supplement De Vitamines Et MinerauxLand Art Inc.
Supplements De Vitamines Et MinerauxLand Art Inc.
Swical D-M - TabLes Laboratoires Swisse Inc.
Swical-multiLes Laboratoires Swisse Inc.
T-PA CapSeroyal International Inc.
Tianshi Calcium and Vitamin D Chewable Tablets (melon Flavour)Tianjin Tianshi Group Co., Ltd.
Tianshi Calcium and Vitamin D Chewable Tablets (peach Flavour)Tianjin Tianshi Group Co., Ltd.
Tianshi Calcium and Vitamin D Chewable Tablets (strawberry Flavour)Tianjin Tianshi Group Co., Ltd.
Tianshi Calcium With Natural Source Vitamin D TabletsTianjin Tianshi Group Co., Ltd.
Tianshi Calcium With Natural Source Vitamin E Softgel CapsulesTianjin Tianshi Group Co., Ltd.
Tianshi Vital Powder ITianjin Tianshi Group Co., Ltd.
Tianshi Vital Powder IITianjin Tianshi Group Co., Ltd.
Tianshi Vital Powder IIITianjin Tianshi Group Co., Ltd.
Timed Release and Esterified Vitamin C-500Great Earth Companies, Inc.
Timed Release Ester-C 1000mgSwiss Herbal Remedies Ltd.
Tri-mins - CapAlbion Laboratories Inc.
Tropicana Calcium & Vitamin C SupplementTropicana Canada
Tropicana Calcium and Vitamin C SupplementTropicana Canada
Tums Ultra Strength Liquid Plus Anti-gasSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.
Ultimatecare One NfTrigen Laboratories, Inc.
Usana Multimineral TabletsUsana Health Sciences Inc.
Usana Multimineral Tablets - TabUsana Health Sciences Inc.
Viamon Ampoules Et ComprimesLab Nadeau LtÉe, Division Of Technilab Inc.
Vimeral TabIcn Canada Ltd.
Vit C W Calc-mag and Potass PowderNf Formulas Inc.
Vita - Gl CapsulesAnton Hubner Gmbh & Co.
Vitaflex Dietary SuplementHome Shopping Network Direct
Vitafol CapletEverett Laboratories, Inc.
Vitafol Ob CapletEverett Laboratories, Inc.
Vitality Brand Calcium Plus TabGolden Neo Life Diamite International, Limited
Vitamin C and Calcium TabNatrol, Inc.
Vitamin C Calcium PwrSisu Inc.
Vitamin D + Calcium Dietary SupplementGarden State Nutritionals
Vitamines A - D CalciumLaboratoire Lalco Inc.
Women's Support TabletsGeneral Nutrition Canada Inc.
ZingiberPru Gen, Inc. Pharmaceuticals
Salts
Name/CASStructureProperties
Calcium acetate
ThumbNot applicableDBSALT001052
Categories
UNIISY7Q814VUP
CAS number7440-70-2
WeightAverage: 40.078
Monoisotopic: 39.962591155
Chemical FormulaCa
InChI KeyInChIKey=OYPRJOBELJOOCE-UHFFFAOYSA-N
InChI
InChI=1S/Ca
IUPAC Name
calcium
SMILES
[Ca]
Taxonomy
ClassificationNot classified
Pharmacology
IndicationCalcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. It is vital in cell signaling, muscular contractions, bone health, and signalling cascades.
PharmacodynamicsCalcium (Ca2+) plays a pivotal role in the physiology and biochemistry of organisms and the cell. It plays an important role in signal transduction pathways, where it acts as a second messenger, in neurotransmitter release from neurons, contraction of all muscle cell types, and fertilization. Many enzymes require calcium ions as a cofactor, those of the blood-clotting cascade being notable examples. Extracellular calcium is also important for maintaining the potential difference across excitable cell membranes, as well as proper bone formation.
Mechanism of actionCalcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. More than 500 human proteins are known to bind or transport calcium. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Parathyroid hormone (secreted from the parathyroid gland) regulates the resorption of Ca2+ from bone. Calcitonin stimulates incorporation of calcium in bone, although this process is largely independent of calcitonin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium. Low calcium intake may also be a risk factor in the development of osteoporosis. The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. Calcium gluconate and calcium lactate are absorbed well by pregnant women. Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast. The currently recommended calcium intake is 1,500 milligrams per day for women not taking estrogen and 800 milligrams per day for women on estrogen. There is close to 300 milligrams of calcium in one cup of fluid milk. Calcium carbonate is currently the best and least expensive form of calcium supplement available.
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationThe kidney excretes 250 mmol a day in urine, and resorbs 245 mmol, leading to a net loss in the urine of 5 mmol/d.
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Beta-Alanine MetabolismMetabolicSMP00007
Phospholipid BiosynthesisMetabolicSMP00025
Pantothenate and CoA BiosynthesisMetabolicSMP00027
Riboflavin MetabolismMetabolicSMP00070
Arachidonic Acid MetabolismMetabolicSMP00075
Meloxicam Action PathwayDrug actionSMP00106
Mefenamic Acid Action PathwayDrug actionSMP00109
Malate-Aspartate ShuttleMetabolicSMP00129
Dicumarol Action PathwayDrug actionSMP00270
Ardeparin Action PathwayDrug actionSMP00275
Streptokinase Action PathwayDrug actionSMP00282
Acebutolol Action PathwayDrug actionSMP00296
Atenolol Action PathwayDrug actionSMP00298
Nadolol Action PathwayDrug actionSMP00303
Oxprenolol Action PathwayDrug actionSMP00304
Pindolol Action PathwayDrug actionSMP00306
Gaucher DiseaseDiseaseSMP00349
17-Beta Hydroxysteroid Dehydrogenase III DeficiencyDiseaseSMP00356
Fc Epsilon Receptor I Signaling in Mast CellsSignalingSMP00358
Gout or Kelley-Seegmiller SyndromeDiseaseSMP00365
Carvedilol Action PathwayDrug actionSMP00367
Tyrosinemia Type 2 (or Richner-Hanhart syndrome)DiseaseSMP00369
Tyrosinemia Type 3 (TYRO3)DiseaseSMP00370
Isradipine Action PathwayDrug actionSMP00378
Prilocaine Action PathwayDrug actionSMP00401
Heroin Action PathwayDrug actionSMP00407
Methadone Action PathwayDrug actionSMP00408
Alfentanil Action PathwayDrug actionSMP00413
Carfentanil Action PathwayDrug actionSMP00414
Azathioprine Action PathwayDrug actionSMP00427
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal AbsorptionNot AvailableNot Available
Blood Brain BarrierNot AvailableNot Available
Caco-2 permeableNot AvailableNot Available
P-glycoprotein substrateNot AvailableNot Available
P-glycoprotein inhibitor INot AvailableNot Available
P-glycoprotein inhibitor IINot AvailableNot Available
Renal organic cation transporterNot AvailableNot Available
CYP450 2C9 substrateNot AvailableNot Available
CYP450 2D6 substrateNot AvailableNot Available
CYP450 3A4 substrateNot AvailableNot Available
CYP450 1A2 substrateNot AvailableNot Available
CYP450 2C9 inhibitorNot AvailableNot Available
CYP450 2D6 inhibitorNot AvailableNot Available
CYP450 2C19 inhibitorNot AvailableNot Available
CYP450 3A4 inhibitorNot AvailableNot Available
CYP450 inhibitory promiscuityNot AvailableNot Available
Ames testNot AvailableNot Available
CarcinogenicityNot AvailableNot Available
BiodegradationNot AvailableNot Available
Rat acute toxicityNot AvailableNot applicable
hERG inhibition (predictor I)Not AvailableNot Available
hERG inhibition (predictor II)Not AvailableNot Available
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Capsuleoral.99 1/1
Powderoral
Granules (effervescents); kit; tabletoral
Tabletoral166.6 mg
Liquid; capsuleoral
Piece (chewable)oral
Tabletoral
Powderoral63.4 mg
Powderoral336 mg
Tabletoral100 mg
Tabletoral30 mg
Waferoral
Capsuleoral150 mg
Tabletoral600 mg
Tabletoral650 mg
Capsuleoral400 mg
Tabletoral246 mg
Capsuleoral160.0 mg
Tabletoral60 mg
Tabletoral120 mg
Capsuleoral100 mg
Tabletoral84.5 mg
Tabletoral84 mg
Liquidoral100 mg
Syruporal100 mg
Syruporal110 mg
Tabletoral150 mg
Tabletoral125 mg
Tabletoral266.7 mg
Powderoral216.7 mg
Capsuleoral500 mg
Kit; tabletoral
Liquidoral803.8 mg/1000mL
Powder for solutionoral
Tabletoral300 mg
Capsuleoral45 mg
Tabletoral.99 1/1
Tabletoral84.2 mg
Tabletoral42.1 mg
Liquidintravenous10 mg
Liquidoral
Liquid; tabletoral
Powder (effervescent)oral
Tablet
Capsule, gelatin coatedoral
Capsuleoral
Tabletoral350 mg
Tabletoral250 mg
Tablet, film coatedoral
Tablet500 mg
Tablet, chewableoral
Tablet (effervescent)oral
Tabletoral200 mg
Tablet (extended-release)oral
Solutionoral1.458 mg
Solutionoral1.667 mg
Tabletoral400 mg
Liquidoral400 mg
Capsuleoral600 mg
Tabletoral500 mg
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point839°CMSDS
boiling point1484°CMSDS
Predicted Properties
PropertyValueSource
Water Solubility0.0 mg/mLALOGPS
logP-1.3ALOGPS
logP-0.57ChemAxon
logS1.08ALOGPS
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis ReferenceUS5667761
General References
  1. Dawson-Hughes B, Harris SS, Krall EA, Dallal GE: Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med. 1997 Sep 4;337(10):670-6. [PubMed:9278463 ]
  2. Weingarten MA, Zalmanovici A, Yaphe J: Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps. Cochrane Database Syst Rev. 2005 Jul 20;(3):CD003548. [PubMed:16034903 ]
  3. Jackson RD, LaCroix AZ, Gass M, Wallace RB, Robbins J, Lewis CE, Bassford T, Beresford SA, Black HR, Blanchette P, Bonds DE, Brunner RL, Brzyski RG, Caan B, Cauley JA, Chlebowski RT, Cummings SR, Granek I, Hays J, Heiss G, Hendrix SL, Howard BV, Hsia J, Hubbell FA, Johnson KC, Judd H, Kotchen JM, Kuller LH, Langer RD, Lasser NL, Limacher MC, Ludlam S, Manson JE, Margolis KL, McGowan J, Ockene JK, O'Sullivan MJ, Phillips L, Prentice RL, Sarto GE, Stefanick ML, Van Horn L, Wactawski-Wende J, Whitlock E, Anderson GL, Assaf AR, Barad D: Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med. 2006 Feb 16;354(7):669-83. [PubMed:16481635 ]
  4. Grant AM, Avenell A, Campbell MK, McDonald AM, MacLennan GS, McPherson GC, Anderson FH, Cooper C, Francis RM, Donaldson C, Gillespie WJ, Robinson CM, Torgerson DJ, Wallace WA: Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet. 2005 May 7-13;365(9471):1621-8. [PubMed:15885294 ]
  5. Porthouse J, Cockayne S, King C, Saxon L, Steele E, Aspray T, Baverstock M, Birks Y, Dumville J, Francis R, Iglesias C, Puffer S, Sutcliffe A, Watt I, Torgerson DJ: Randomised controlled trial of calcium and supplementation with cholecalciferol (vitamin D3) for prevention of fractures in primary care. BMJ. 2005 Apr 30;330(7498):1003. [PubMed:15860827 ]
External Links
ATC CodesA11AA02M05BB01M05BB02M05BB04M05BB05M05BB08
AHFS Codes
  • 34:00.00
  • 40:12.00
  • 40:18.17
  • 40:18.19
  • 40:34.00*
  • 56:04.00
  • 56:12.00
  • 88:08.00
  • 88:12.00
  • 88:29.00*
  • 92:02.00*
PDB EntriesNot Available
FDA labelDownload (25.6 KB)
MSDSDownload (47.9 KB)
Interactions
Drug InteractionsNot Available
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
ligand
General Function:
Voltage-gated calcium channel activity
Specific Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belon...
Gene Name:
CACNA1C
Uniprot ID:
Q13936
Molecular Weight:
248974.1 Da
References
  1. Boda D, Giri J, Henderson D, Eisenberg B, Gillespie D: Analyzing the components of the free-energy landscape in a calcium selective ion channel by Widom's particle insertion method. J Chem Phys. 2011 Feb 7;134(5):055102. doi: 10.1063/1.3532937. [PubMed:21303162 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Signal transducer activity
Specific Function:
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.
Gene Name:
ATP2C1
Uniprot ID:
P98194
Molecular Weight:
100576.42 Da
References
  1. Shi X, Chen M, Huvos PE, Hardwicke PM: Amino acid sequence of a Ca(2+)-transporting ATPase from the sarcoplasmic reticulum of the cross-striated part of the adductor muscle of the deep sea scallop: comparison to serca enzymes of other animals. Comp Biochem Physiol B Biochem Mol Biol. 1998 Jun;120(2):359-74. [PubMed:9787799 ]
  2. Bonza MC, Martin H, Kang M, Lewis G, Greiner T, Giacometti S, Van Etten JL, De Michelis MI, Thiel G, Moroni A: A functional calcium-transporting ATPase encoded by chlorella viruses. J Gen Virol. 2010 Oct;91(Pt 10):2620-9. doi: 10.1099/vir.0.021873-0. Epub 2010 Jun 23. [PubMed:20573858 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Calcium ion binding
Specific Function:
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Gene Name:
TNNC2
Uniprot ID:
P02585
Molecular Weight:
18121.895 Da
References
  1. Martin SR, Avella G, Adrover M, de Nicola GF, Bullard B, Pastore A: Binding properties of the calcium-activated F2 isoform of Lethocerus troponin C. Biochemistry. 2011 Mar 22;50(11):1839-47. doi: 10.1021/bi102076s. Epub 2011 Feb 10. [PubMed:21250664 ]
  2. Kreutziger KL, Piroddi N, McMichael JT, Tesi C, Poggesi C, Regnier M: Calcium binding kinetics of troponin C strongly modulate cooperative activation and tension kinetics in cardiac muscle. J Mol Cell Cardiol. 2011 Jan;50(1):165-74. doi: 10.1016/j.yjmcc.2010.10.025. Epub 2010 Oct 28. [PubMed:21035455 ]
  3. Robertson IM, Sun YB, Li MX, Sykes BD: A structural and functional perspective into the mechanism of Ca2+-sensitizers that target the cardiac troponin complex. J Mol Cell Cardiol. 2010 Dec;49(6):1031-41. doi: 10.1016/j.yjmcc.2010.08.019. Epub 2010 Aug 27. [PubMed:20801130 ]
  4. Dweck D, Reynaldo DP, Pinto JR, Potter JD: A dilated cardiomyopathy troponin C mutation lowers contractile force by reducing strong myosin-actin binding. J Biol Chem. 2010 Jun 4;285(23):17371-9. doi: 10.1074/jbc.M109.064105. Epub 2010 Apr 6. [PubMed:20371872 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Troponin t binding
Specific Function:
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Gene Name:
TNNC1
Uniprot ID:
P63316
Molecular Weight:
18402.36 Da
References
  1. Dweck D, Reynaldo DP, Pinto JR, Potter JD: A dilated cardiomyopathy troponin C mutation lowers contractile force by reducing strong myosin-actin binding. J Biol Chem. 2010 Jun 4;285(23):17371-9. doi: 10.1074/jbc.M109.064105. Epub 2010 Apr 6. [PubMed:20371872 ]
  2. Swindle N, Tikunova SB: Hypertrophic cardiomyopathy-linked mutation D145E drastically alters calcium binding by the C-domain of cardiac troponin C. Biochemistry. 2010 Jun 15;49(23):4813-20. doi: 10.1021/bi100400h. [PubMed:20459070 ]
  3. Parvatiyar MS, Pinto JR, Liang J, Potter JD: Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C. J Biol Chem. 2010 Sep 3;285(36):27785-97. doi: 10.1074/jbc.M110.112326. Epub 2010 Jun 21. [PubMed:20566645 ]
  4. Baylor SM, Hollingworth S: Calcium indicators and calcium signalling in skeletal muscle fibres during excitation-contraction coupling. Prog Biophys Mol Biol. 2011 May;105(3):162-79. doi: 10.1016/j.pbiomolbio.2010.06.001. Epub 2010 Jun 25. [PubMed:20599552 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Structural constituent of cytoskeleton
Specific Function:
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
Gene Name:
SPTBN1
Uniprot ID:
Q01082
Molecular Weight:
274606.995 Da
References
  1. Wallis CJ, Wenegieme EF, Babitch JA: Characterization of calcium binding to brain spectrin. J Biol Chem. 1992 Mar 5;267(7):4333-7. [PubMed:1537825 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within...
Gene Name:
S100B
Uniprot ID:
P04271
Molecular Weight:
10712.985 Da
References
  1. Lee TS, Mane S, Eid T, Zhao H, Lin A, Guan Z, Kim JH, Schweitzer J, King-Stevens D, Weber P, Spencer SS, Spencer DD, de Lanerolle NC: Gene expression in temporal lobe epilepsy is consistent with increased release of glutamate by astrocytes. Mol Med. 2007 Jan-Feb;13(1-2):1-13. [PubMed:17515952 ]
  2. Marlatt NM, Shaw GS: Amide exchange shows calcium-induced conformational changes are transmitted to the dimer interface of S100B. Biochemistry. 2007 Jun 26;46(25):7478-87. Epub 2007 May 31. [PubMed:17536784 ]
  3. Liang J, Luo G, Ning X, Shi Y, Zhai H, Sun S, Jin H, Liu Z, Zhang F, Lu Y, Zhao Y, Chen X, Zhang H, Guo X, Wu K, Fan D: Differential expression of calcium-related genes in gastric cancer cells transfected with cellular prion protein. Biochem Cell Biol. 2007 Jun;85(3):375-83. [PubMed:17612632 ]
  4. Friel LA, Romero R, Edwin S, Nien JK, Gomez R, Chaiworapongsa T, Kusanovic JP, Tolosa JE, Hassan SS, Espinoza J: The calcium binding protein, S100B, is increased in the amniotic fluid of women with intra-amniotic infection/inflammation and preterm labor with intact or ruptured membranes. J Perinat Med. 2007;35(5):385-93. [PubMed:17624933 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Poly(a) rna binding
Specific Function:
Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
Gene Name:
CAST
Uniprot ID:
P20810
Molecular Weight:
76572.035 Da
References
  1. Hanna RA, Garcia-Diaz BE, Davies PL: Calpastatin simultaneously binds four calpains with different kinetic constants. FEBS Lett. 2007 Jun 26;581(16):2894-8. Epub 2007 May 25. [PubMed:17543955 ]
  2. De Tullio R, Averna M, Stifanese R, Parr T, Bardsley RG, Pontremoli S, Melloni E: Multiple rat brain calpastatin forms are produced by distinct starting points and alternative splicing of the N-terminal exons. Arch Biochem Biophys. 2007 Sep 1;465(1):148-56. Epub 2007 May 30. [PubMed:17570336 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Protease binding
Specific Function:
May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both pr...
Gene Name:
COMP
Uniprot ID:
P49747
Molecular Weight:
82859.88 Da
References
  1. Chen FH, Herndon ME, Patel N, Hecht JT, Tuan RS, Lawler J: Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan. J Biol Chem. 2007 Aug 24;282(34):24591-8. Epub 2007 Jun 22. [PubMed:17588949 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Titin binding
Specific Function:
Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.
Gene Name:
CALM1
Uniprot ID:
P62158
Molecular Weight:
16837.47 Da
References
  1. Sosa V, Carbo R, Guarner V: Participation of glucose transporters on atrial natriuretic peptide-induced glucose uptake by adult and neonatal cardiomyocytes under oxygenation and hypoxia. Eur J Pharmacol. 2007 Jul 30;568(1-3):83-8. Epub 2007 Apr 30. [PubMed:17537429 ]
  2. Zhou Z, Yin J, Dou Z, Tang J, Zhang C, Cao Y: The calponin homology domain of Vav1 associates with calmodulin and is prerequisite to T cell antigen receptor-induced calcium release in Jurkat T lymphocytes. J Biol Chem. 2007 Aug 10;282(32):23737-44. Epub 2007 Jun 5. [PubMed:17550897 ]
  3. Schallreuter KU, Gibbons NC, Zothner C, Abou Elloof MM, Wood JM: Hydrogen peroxide-mediated oxidative stress disrupts calcium binding on calmodulin: more evidence for oxidative stress in vitiligo. Biochem Biophys Res Commun. 2007 Aug 17;360(1):70-5. Epub 2007 Jun 11. [PubMed:17592724 ]
  4. Caride AJ, Filoteo AG, Penniston JT, Strehler EE: The plasma membrane Ca2+ pump isoform 4a differs from isoform 4b in the mechanism of calmodulin binding and activation kinetics: implications for Ca2+ signaling. J Biol Chem. 2007 Aug 31;282(35):25640-8. Epub 2007 Jun 26. [PubMed:17595168 ]
  5. Lo LW, Chen YC, Chen YJ, Wongcharoen W, Lin CI, Chen SA: Calmodulin kinase II inhibition prevents arrhythmic activity induced by alpha and beta adrenergic agonists in rabbit pulmonary veins. Eur J Pharmacol. 2007 Oct 1;571(2-3):197-208. Epub 2007 Jun 13. [PubMed:17612522 ]
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Drug created on July 06, 2007 14:28 / Updated on March 14, 2014 14:36