Displaying drugs 126 - 150 of 265 in total
Halcinonide
Halcinonide is a corticosteroid indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses, and is distributed as a cream and ointment. Halcinonide is marketed under the brand name Halog® by Ranbaxy Laboratories Inc. Research suggests that clobetasol propionate demonstrates superior pharmacologic efficacy in the treatment of...
Approved
Investigational
Withdrawn
Matched Description: … of corticosteroid-responsive dermatoses, and is distributed as a cream and ointment. ... Halcinonide is a corticosteroid indicated for the relief of the inflammatory and pruritic manifestations …
Montelukast
Montelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair. The medication is a member of the leukotriene receptor antagonist (LTRA) category of drugs.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Although capable of demonstrating effectiveness, the use of such LTRAs like montelukast is typically in addition to or...
Approved
Matched Description: … has since become available as a generic and as a brand name product. ... montelukast to elicit neuropsychiatric effects like agitation, hallucinations, suicidal behaviour, and ... L6325,L6328,L6331] the drug still sees extensive use worldwide via millions of prescriptions annually and …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Clobetasol propionate
Clobetasol propionate is a prednisolone derivative with higher specificity for glucocorticoid receptors than mineralocorticoid receptors. It has demonstrated superior activity compared to fluocinonide and was first described in the literature in 1974. Clobetasol Propionate was granted FDA approval on 27 December 1985.
Approved
Matched Description: … [L11815] It has demonstrated superior activity compared to [fluocinonide][A190963] and was first described …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Fluclorolone acetonide
Fluclorolone acetonide (INN) or flucloronide (USAN) is a topical corticosteroid. It is marketed under the brand names Cutanit and Topicon.
Approved
Withdrawn
Matched Description: … It is marketed under the brand names Cutanit and Topicon. …
Asciminib
Asciminib is a tyrosine kinase inhibitor (TKI) used in the treatment of chronic-phase Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). More specifically, it is an inhibitor of the ABL1 kinase activity of the BCR-ABL1 fusion protein which serves as a driver of CML proliferation in most patients with the disease....
Approved
Investigational
Matched Description: … those that target the active conformation of the kinase domain ([dasatinib], [bosutinib]) and those ... Existing inhibitors of ABL compete at the ATP binding sites of these proteins and can be classified into ... in that it acts as an allosteric inhibitor, binding at the myristoyl pocket of the BCR-ABL1 protein and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Capivasertib
Hormone receptor (HR) positive, especially estrogen receptor-positive, HER2-negative breast cancer is the most common subtype of metastatic breast cancer, resulting in more than 400,000 deaths annually. Although endocrine-based therapy is the first line of treatment, resistance eventually emerges, leaving chemotherapy the only but often ineffective treatment left. Therefore, significant research...
Approved
Investigational
Matched Description: … based on favorable results obtained from the CAPItello-291 trial, where the combination of capivasertib and …
Delafloxacin
Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in the treatment of...
Approved
Investigational
Matched Description: … Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and ... basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and ... approved in June 2017 under the trade name Baxdela for use in the treatment of acute bacterial skin and …
Cangrelor
Cangrelor is an intravenous, direct-acting, reversible P2Y12 inhibitor for patients undergoing percutaneous coronary intervention (PCI) who have not been yet treated by oral P2Y12 inhibitors. An advantage Cangrelor provides over oral P2Y12 inhibitors (such as prasugrel, ticagrelor, and clopidogrel) is that it is an active drug not requiring metabolic conversion...
Approved
Matched Description: … ) is that it is an active drug not requiring metabolic conversion therefore providing a rapid onset and ... An advantage Cangrelor provides over oral P2Y12 inhibitors (such as prasugrel, ticagrelor, and clopidogrel …
Matched Categories: … Blood and Blood Forming Organs ... Nucleic Acids, Nucleotides, and Nucleosides …
Matched Categories: … Blood and Blood Forming Organs ... Nucleic Acids, Nucleotides, and Nucleosides …
Telavancin
Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and subcutaneous tissue infections among others.
Approved
Matched Description: … skin and subcutaneous tissue infections among others. ... vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and ... pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Abarelix
Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market.
Approved
Investigational
Withdrawn
Matched Categories: … Amino Acids, Peptides, and Proteins ... Hormone Antagonists and Related Agents ... Antineoplastic and Immunomodulating Agents ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Carisbamate
Carisbamate has been investigated in Alcohol Abuse, Substance Abuse, and Alcohol Dependence.
Investigational
Matched Description: … Carisbamate has been investigated in Alcohol Abuse, Substance Abuse, and Alcohol Dependence. …
Benzoxonium
Experimental
Matched Salts name: … Benzoxonium chloride …
Matched Categories: … benzoxonium chloride ... benzoxonium chloride ... Alimentary Tract and Metabolism ... Antiseptics and Disinfectants ... Antiinfectives and Antiseptics for Local Oral Treatment …
Matched Categories: … benzoxonium chloride ... benzoxonium chloride ... Alimentary Tract and Metabolism ... Antiseptics and Disinfectants ... Antiinfectives and Antiseptics for Local Oral Treatment …
Bimoclomol
Bimoclomol is an investigational drug that induces stress proteins and has cytoprotective effects.
Investigational
Matched Iupac: … (Z)-N-[2-hydroxy-3-(piperidin-1-yl)propoxy]pyridine-3-carbonimidoyl chloride …
Matched Description: … Bimoclomol is an investigational drug that induces stress proteins and has cytoprotective effects. …
Matched Description: … Bimoclomol is an investigational drug that induces stress proteins and has cytoprotective effects. …
Tridihexethyl
Tridihexethyl is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. Tridihexethyl is an antimuscarinic, anticholinergic drug. Tridihexethyl is no longer available in the US market.
Withdrawn
Matched Description: … Tridihexethyl is a synthetic anticholinergic agent which has been shown in experimental and clinical ... studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. …
Matched Salts name: … Tridihexethyl chloride …
Matched Categories: … Alimentary Tract and Metabolism …
Matched Salts name: … Tridihexethyl chloride …
Matched Categories: … Alimentary Tract and Metabolism …
Clomethiazole
Clomethiazole is a well-established γ-aminobutyric acid (GABAA)-mimetic drug. It is a sedative and hypnotic that is widely used in treating and preventing symptoms of acute alcohol withdrawal. It is a drug which is structurally related to thiamine (vitamin B1) but acts like a sedative, hypnotic, muscle relaxant and anticonvulsant. It...
Investigational
Matched Description: … It is a sedative and hypnotic that is widely used in treating and preventing symptoms of acute alcohol ... is structurally related to thiamine (vitamin B1) but acts like a sedative, hypnotic, muscle relaxant and ... It is also used for the management of agitation, restlessness, short-term insomnia and Parkinson's disease …
Matched Categories: … Hypnotics and Sedatives …
Matched Categories: … Hypnotics and Sedatives …
Picrotoxin
A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the gamma-aminobutyric acid-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates. [PubChem]
Experimental
Matched Description: … Picrotoxin blocks the gamma-aminobutyric acid-activated chloride ionophore. ... A noncompetitive antagonist at GABA-A receptors and thus a convulsant. ... Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote …
Lesopitron
Lesopitron is an anxiolytic with pre- and post-synaptic 5-HT1A agonist activity, which is under development by Esteve.
Investigational
Matched Description: … Lesopitron is an anxiolytic with pre- and post-synaptic 5-HT1A agonist activity, which is under development …
Denufosol
Denufosol was an inhaled drug used for the treatment of cystic fibrosis (CF), showing various improvements in lung function during a phase III clinical trial. A new drug application (NDA) was filed with the FDA in 2011, however, the second phase III clinical trial showed a lack of improvement in...
Investigational
Matched Description: … Denufosol has not gained FDA approval, and clinical trials with this drug have ceased since 2011. ... The drug was also evaluated in the treatment of retinal detachment and other diseases of the retina. …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Alcuronium
A non-depolarizing skeletal muscle relaxant similar to tubocurarine. It is used as an anesthesia adjuvant.
Experimental
Matched Salts name: … Alcuronium chloride …
Delorazepam
Delorazepam is a benzodiazepine which, like other drugs in its class, possesses anxiolytic, skeletal muscle relaxant, hypnotic and anticonvulsant properties. It may have adverse effects such as drowsiness, and cognitive impairments such as short term memory impairment.
Delorazepam is an active metabolite of the benzodiazepine known as cloxazolam. It is...
Experimental
Illicit
Matched Description: … benzodiazepine which, like other drugs in its class, possesses anxiolytic, skeletal muscle relaxant, hypnotic and ... It may have adverse effects such as drowsiness, and cognitive impairments such as short term memory impairment …
Matched Categories: … Benzodiazepines and benzodiazepine derivatives …
Matched Categories: … Benzodiazepines and benzodiazepine derivatives …
SD-0006
Investigational
(1R)-3-chloro-1-phenylpropan-1-ol
Experimental
Ornidazole
Ornidazole has been used in trials studying the prevention of Elective Colorectal Surgery.
Investigational
Matched Categories: … cefixime and ornidazole ... ofloxacin and ornidazole ... levofloxacin and ornidazole ... ciprofloxacin and ornidazole ... Genito Urinary System and Sex Hormones …
Cloridarol
Cloridarol is an experimental medication in the treatment of heart disease, which acts through vasodilation. It was studied for the treatment of coronary insufficiency in Italy in the 1970s .
Experimental
Displaying drugs 126 - 150 of 265 in total