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Identification
NameClobetasol propionate
Accession NumberDB01013  (APRD00876)
TypeSmall Molecule
GroupsApproved
Description

A derivative of prednisolone with high glucocorticoid activity and low mineralocorticoid activity. Absorbed through the skin faster than fluocinonide, it is used topically in treatment of psoriasis but may cause marked adrenocortical suppression. [PubChem]

Structure
Thumb
Synonyms
21-chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate
clobetasol 17-propanoate
clobetasol 17-propionate
Clobetasol propionate E
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Alti-clobetasol Propionate Cream 0.05%cream.05 %topicalAltimed Pharma Inc.1993-12-312001-09-05Canada
Alti-clobetasol Propionate Ont 0.05%ointment.05 %topicalAltimed Pharma Inc.1993-12-312001-09-05Canada
Alti-clobetasol Propionate Scalp Application 0.05%liquid.05 %topicalAltimed Pharma Inc.1993-12-312001-09-05Canada
Clobetasol Cream 0.05%cream0.05 %topicalPrempharm Inc1996-12-232005-08-05Canada
Clobetasol Ointment 0.05%ointment0.05 %topicalPrempharm Inc1996-12-232005-08-05Canada
Clobetasol Propionateaerosol, foam.5 mg/gtopicalRenaissance Pharma, Inc.2014-02-06Not applicableUs
Clobetasol Propionateaerosol, foam.5 mg/gtopicalPrasco Laboratories2010-01-152016-03-04Us
Clobetasol Propionateshampoo.05 g/100mLtopicalSandoz Inc.2011-12-22Not applicableUs
Clobetasol Propionateaerosol, foam.5 mg/gtopicalPhysicians Total Care, Inc.2011-08-16Not applicableUs
Clobetasol Propionatespray.05 g/mLtopicalActavis Pharma, Inc.2015-08-28Not applicableUs
Clobetasol Propionatelotion.5 mg/mLtopicalPaddock Laboratories, LLC2012-01-03Not applicableUs
Clobetasol Propionate Emulsionaerosol, foam.5 mg/gtopicalPrasco Laboratories2013-02-012015-11-30Us
Clobetasol Propionate Emulsionaerosol, foam.5 mg/gtopicalRenaissance Pharma, Inc.2014-02-06Not applicableUs
Clobetasol Scalp Application 0.05%ointment0.05 %topicalPrempharm Inc1996-12-232005-08-05Canada
Clobexshampoo.05 g/100mLtopicalGalderma Laboratories, L.P.2004-03-01Not applicableUs
Clobexspray.05 g/mLtopicalGalderma Laboratories, L.P.2005-10-27Not applicableUs
Clobexlotion.05 mL/100mLtopicalPhysicians Total Care, Inc.2006-08-16Not applicableUs
Clobexspray.5 mg/mLtopicalPhysicians Total Care, Inc.2006-01-23Not applicableUs
Clobexlotion.05 g/100mLtopicalGalderma Laboratories, L.P.2003-08-01Not applicableUs
Clobex Lotionlotion0.05 %topicalGalderma Canada Inc2005-12-09Not applicableCanada
Clobex Shampooshampoo0.05 %topicalGalderma Canada Inc2004-12-15Not applicableCanada
Clobex Spraysolution0.05 %topicalGalderma Canada Inc2007-12-19Not applicableCanada
Dermovate Creamcream0.05 %topicalTaropharma, A Division Of Taro Pharmaceuticals Inc.1999-09-07Not applicableCanada
Dermovate Crm 0.05%cream.05 %topicalGlaxo Canada Inc1976-12-312000-08-02Canada
Dermovate Ointmentointment.05 %topicalTaropharma, A Division Of Taro Pharmaceuticals Inc.1999-12-20Not applicableCanada
Dermovate Ont 0.05%ointment.05 %topicalGlaxo Canada Inc1976-12-312000-08-02Canada
Dermovate Scalp Applicationsolution.05 %topicalTaropharma, A Division Of Taro Pharmaceuticals Inc.2001-06-25Not applicableCanada
Dermovate Scalp Application .05%liquid.05 %topicalGlaxo Canada Inc1980-12-312001-08-01Canada
Mylan-clobetasol Creamcream0.05 %topicalMylan Pharmaceuticals Ulc1993-12-31Not applicableCanada
Mylan-clobetasol Ointmentointment0.05 %topicalMylan Pharmaceuticals Ulc1993-12-31Not applicableCanada
Mylan-clobetasol Scalp Applicationlotion0.05 %topicalMylan Pharmaceuticals Ulc1996-09-10Not applicableCanada
Novo-clobetasol Crm 0.05%cream.05 %topicalNovopharm Limited1996-12-31Not applicableCanada
Novo-clobetasol Ointment - 0.05%ointment.05 %topicalNovopharm Limited1996-12-31Not applicableCanada
Oluxaerosol, foam.5 mg/gtopicalPhysicians Total Care, Inc.2005-09-15Not applicableUs
Oluxaerosol, foam.5 mg/gtopicalPrestium Pharma, Inc.2014-02-07Not applicableUs
Olux-Eaerosol, foam0.05 %topicalGlaxosmithkline Inc2013-02-04Not applicableCanada
Olux-Eaerosol, foam.5 mg/gtopicalPrestium Pharma, Inc.2007-02-12Not applicableUs
Penta-clobetasol Creamcream.05 %topicalPentapharm Ltd.Not applicableNot applicableCanada
PMS-clobetasolointment0.05 %topicalPharmascience Inc2011-02-21Not applicableCanada
PMS-clobetasolcream0.05 %topicalPharmascience Inc2011-09-09Not applicableCanada
PMS-clobetasol Creamcream0.05 %topicalPharmascience Inc1998-03-06Not applicableCanada
PMS-clobetasol Ointmentointment0.05 %topicalPharmascience Inc1998-03-06Not applicableCanada
PMS-clobetasol Scalp Applicationliquid0.05 %topicalPharmascience Inc1998-06-18Not applicableCanada
Ratio-clobetasolcream0.05 %topicalTeva Canada Limited1992-12-31Not applicableCanada
Ratio-clobetasolointment0.05 %topicalTeva Canada Limited1992-12-31Not applicableCanada
Ratio-clobetasollotion0.05 %topicalTeva Canada Limited1992-12-31Not applicableCanada
Taro-clobetasol Cream USP, 0.05%cream0.05 %topicalTaro Pharmaceuticals Inc2002-04-22Not applicableCanada
Taro-clobetasol Ointment USP, 0.05%ointment0.05 %topicalTaro Pharmaceuticals Inc2002-04-22Not applicableCanada
Taro-clobetasol Topical Solution USP, 0.05%solution0.05 %topicalTaro Pharmaceuticals Inc2002-04-22Not applicableCanada
Temovategel.5 mg/gtopicalPharma Derm, A Division Of Fougera Pharmaceuticals Inc.1994-04-29Not applicableUs
Temovatecream.5 mg/gtopicalPharma Derm A Division Of Fougera Pharmaceuticals Inc.1985-12-27Not applicableUs
Temovateointment.5 mg/gtopicalPharma Derm A Division Of Fougera Pharmaceuticals Inc.1985-12-27Not applicableUs
Temovatecream.5 mg/gtopicalPharma Derm A Division Of Fougera Pharmaceuticals Inc.1994-06-17Not applicableUs
Temovate Scalp Applicationsolution.5 mg/mLtopicalPharma Derm, A Division Of Fougera Pharmaceuticals Inc.1990-02-22Not applicableUs
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Clobetasol Propionatecream.5 mg/gtopicalGolden State Medical Supply, Inc.1996-07-12Not applicableUs
Clobetasol Propionategel.5 mg/gtopicalHi Tech Pharmacal Co., Inc.2010-06-07Not applicableUs
Clobetasol Propionategel.05 mg/gtopicalDIRECT RX2015-01-01Not applicableUs
Clobetasol Propionatecream.5 mg/gtopicalUnit Dose Services1996-09-30Not applicableUs
Clobetasol Propionatesolution.5 mg/mLtopicalRebel Distributors Corp1998-11-13Not applicableUs
Clobetasol Propionatelotion.5 mg/mLtopicalTaro Pharmaceuticals U.S.A., Inc.2012-07-02Not applicableUs
Clobetasol Propionateaerosol, foam.5 mg/gtopicalPerrigo New York Inc2008-03-20Not applicableUs
Clobetasol Propionatecream.5 mg/gtopicalActavis Pharma, Inc.2015-03-10Not applicableUs
Clobetasol Propionateointment.5 mg/gtopicalG&W Laboratories, Inc.2016-01-04Not applicableUs
Clobetasol Propionateointment.5 mg/gtopicalGolden State Medical Supply, Inc.1996-07-12Not applicableUs
Clobetasol Propionateointment.5 mg/gtopicalHi Tech Pharmacal Co., Inc.2010-06-07Not applicableUs
Clobetasol Propionatecream.5 mg/gtopicalTaro Pharmaceuticals U.S.A., Inc.2000-05-17Not applicableUs
Clobetasol Propionatecream.5 mg/gtopicalPreferred Pharmaceuticals, Inc.2012-01-30Not applicableUs
Clobetasol Propionateemulsion.5 mg/gtopicalPhysicians Total Care, Inc.2011-09-07Not applicableUs
Clobetasol Propionatecream.5 mg/gtopicalHi Tech Pharmacal Co., Inc.2010-06-07Not applicableUs
Clobetasol Propionategel.5 mg/gtopicalTaro Pharmaceuticals U.S.A., Inc.1999-05-28Not applicableUs
Clobetasol Propionategel.5 mg/gtopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.2000-02-15Not applicableUs
Clobetasol Propionatecream.5 mg/gtopicalPreferred Pharmaceuticals, Inc.2012-04-23Not applicableUs
Clobetasol Propionatesolution.462 mg/mLtopicalPhysicians Total Care, Inc.2005-05-12Not applicableUs
Clobetasol Propionatesolution.4625 mg/mLtopicalHi Tech Pharmacal Co., Inc.2010-06-07Not applicableUs
Clobetasol Propionatespray.5 mg/mLtopicalPaddock Laboratories, LLC2015-01-02Not applicableUs
Clobetasol Propionatesolution.5 mg/mLtopicalTaro Pharmaceuticals U.S.A., Inc.1998-11-16Not applicableUs
Clobetasol Propionateointment.5 mg/gtopicalRebel Distributors Corp2010-06-07Not applicableUs
Clobetasol Propionatesolution.5 mg/mLtopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.1999-02-08Not applicableUs
Clobetasol Propionateointment.5 mg/gtopicalPreferred Pharmaceuticals, Inc.2012-04-23Not applicableUs
Clobetasol Propionatelotion.05 g/100mLtopicalActavis Mid Atlantic LLC2012-01-03Not applicableUs
Clobetasol Propionateointment.5 mg/gtopicalPhysicians Total Care, Inc.2005-03-02Not applicableUs
Clobetasol Propionateshampoo.05 g/100mLtopicalPerrigo New York Inc2012-08-10Not applicableUs
Clobetasol Propionatecream.5 mg/gtopicalRebel Distributors Corp2010-06-07Not applicableUs
Clobetasol Propionatecream.5 mg/gtopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.1996-09-30Not applicableUs
Clobetasol Propionateointment.5 mg/gtopicalPreferred Pharmaceuticals, Inc.2014-03-05Not applicableUs
Clobetasol Propionateointment.5 mg/gtopicalTaro Pharmaceuticals U.S.A., Inc.1996-07-12Not applicableUs
Clobetasol Propionateshampoo.05 g/100mLtopicalActavis Mid Atlantic LLC2012-01-03Not applicableUs
Clobetasol Propionatecream.5 mg/gtopicalPhysicians Total Care, Inc.1997-05-02Not applicableUs
Clobetasol Propionategel.05 mg/gtopicalPerrigo New York Inc2008-07-30Not applicableUs
Clobetasol Propionatesolution.5 mg/mLtopicalMorton Grove Pharmaceuticals, Inc.1998-11-13Not applicableUs
Clobetasol Propionateemulsion.5 mg/gtopicalHi Tech Pharmacal Co., Inc.2010-06-07Not applicableUs
Clobetasol Propionatecream.5 mg/gtopicalRebel Distributors Corp1996-09-30Not applicableUs
Clobetasol Propionateointment.5 mg/gtopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.1996-02-23Not applicableUs
Clobetasol Propionateointment.5 mg/gtopicalPreferred Pharmaceuticals, Inc.2013-04-19Not applicableUs
Clobetasol Propionatecream.5 mg/gtopicalTaro Pharmaceuticals U.S.A., Inc.1996-07-08Not applicableUs
Clobetasol Propionateointment.5 mg/gtopicalRebel Distributors Corp1996-02-23Not applicableUs
Clobetasol Propionatesolution.5 mg/mLtopicalActavis Pharma, Inc.2015-05-29Not applicableUs
Clobetasol Propionate (emollient)cream.5 mg/gtopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.1999-05-26Not applicableUs
Clobetasol Propionate Emollient Formulationaerosol, foam.5 mg/gtopicalPerrigo New York Inc2013-02-01Not applicableUs
Clodanshampoo.5 mg/mLtopicalMedimetriks Pharmaceuticals2014-06-22Not applicableUs
Clodan KitkitMedimetriks Pharmaceuticals2014-06-15Not applicableUs
Cormaxsolution.4625 mg/mLtopicalECR Pharmaceuticals Co., Inc.2012-07-05Not applicableUs
Cormaxointment.5 mg/gtopicalWatson Pharma, Inc.2008-09-18Not applicableUs
Temovatecream.5 mg/gtopicalPharma Derm, A Division Of Fougera Pharmaceuticals Inc.1985-12-27Not applicableUs
Temovateointment.5 mg/gtopicalPharma Derm, A Division Of Fougera Pharmaceuticals Inc.1985-12-27Not applicableUs
Temovate Ecream.5 mg/gtopicalPharma Derm A Division Of Fougera Pharmaceuticals Inc.1999-05-26Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
ClobesolGlaxoSmithKline
DermovateGlaxoSmithKline
EmbelineHi-Tech
Embeline EHi-Tech
Brand mixturesNot Available
SaltsNot Available
Categories
UNII779619577M
CAS number25122-46-7
WeightAverage: 466.97
Monoisotopic: 466.192230046
Chemical FormulaC25H32ClFO5
InChI KeyInChIKey=CBGUOGMQLZIXBE-KBUOYLHWNA-N
InChI
InChI=1/C25H32ClFO5/c1-5-21(31)32-25(20(30)13-26)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,27)19(29)12-23(18,25)4/h8-9,11,14,17-19,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/s2
IUPAC Name
(1R,2S,10S,11S,13S,14R,15S,17S)-14-(2-chloroacetyl)-1-fluoro-17-hydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-14-yl propanoate
SMILES
[H][C@@]12C[[email protected]](C)[C@](OC(=O)CC)(C(=O)CCl)[C@@]1(C)C[[email protected]](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as gluco/mineralocorticoids, progestogins and derivatives. These are steroids with a structure based on a hydroxylated prostane moiety.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassPregnane steroids
Direct ParentGluco/mineralocorticoids, progestogins and derivatives
Alternative Parents
Substituents
  • Progestogin-skeleton
  • Steroid ester
  • 20-oxosteroid
  • 11-hydroxysteroid
  • 11-beta-hydroxysteroid
  • Oxosteroid
  • Hydroxysteroid
  • Halo-steroid
  • 9-halo-steroid
  • 3-oxosteroid
  • 3-oxo-delta-1,4-steroid
  • Delta-1,4-steroid
  • Alpha-acyloxy ketone
  • Cyclic alcohol
  • Cyclic ketone
  • Secondary alcohol
  • Ketone
  • Halohydrin
  • Fluorohydrin
  • Carboxylic acid ester
  • Monocarboxylic acid or derivatives
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organofluoride
  • Organochloride
  • Organohalogen compound
  • Carbonyl group
  • Alkyl halide
  • Alkyl fluoride
  • Alkyl chloride
  • Alcohol
  • Aliphatic homopolycyclic compound
Molecular FrameworkAliphatic homopolycyclic compounds
External Descriptors
Pharmacology
IndicationFor short-term topical treatment of the inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp.
PharmacodynamicsLike other topical corticosteroids, clobetasol has anti-inflammatory, antipruritic, and vasoconstrictive properties. It is a very high potency topical corticosteroid that should not be used with occlusive dressings. It is recommended that treatment should be limited to 2 consecutive weeks and therapy should be discontinued when adequate results have been achieved.
Mechanism of actionThe precise mechanism of the antiinflammatory activity of topical steroids in the treatment of steroid-responsive dermatoses, in general, is uncertain. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. Initially, however, clobetasol, like other corticosteroids, bind to the glucocorticoid receptor, which complexes, enteres the cell nucleus and modifies genetic transcription (transrepression/transactivation).
Related Articles
AbsorptionTopical corticosteroids can be absorbed from intact healthy skin. The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier. Occlusion, inflammation and/or other disease processes in the skin may also increase percutaneous absorption.
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Metabolized, primarily in the liver, and then excreted by the kidneys.

Route of eliminationCorticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids, including clobetasol propionate and its metabolites, are also excreted into the bile.
Half lifeNot Available
ClearanceNot Available
ToxicityOral LD50 in rat and mouse is >3000 mg/kg. Topically applied clobetasol can be absorbed in sufficient amounts to produce systemic effects. Symptoms of overdose include thinning of skin and suppression of adrenal cortex (decreased ability to respond to stress).
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.9814
Caco-2 permeable+0.812
P-glycoprotein substrateSubstrate0.7852
P-glycoprotein inhibitor INon-inhibitor0.7375
P-glycoprotein inhibitor IINon-inhibitor0.7683
Renal organic cation transporterNon-inhibitor0.7883
CYP450 2C9 substrateNon-substrate0.8533
CYP450 2D6 substrateNon-substrate0.9077
CYP450 3A4 substrateSubstrate0.7967
CYP450 1A2 substrateNon-inhibitor0.9412
CYP450 2C9 inhibitorNon-inhibitor0.8713
CYP450 2D6 inhibitorNon-inhibitor0.8327
CYP450 2C19 inhibitorNon-inhibitor0.9126
CYP450 3A4 inhibitorNon-inhibitor0.5411
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9129
Ames testNon AMES toxic0.8848
CarcinogenicityNon-carcinogens0.935
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.1435 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9314
hERG inhibition (predictor II)Non-inhibitor0.5569
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Perrigo israel pharmaceuticals ltd
  • Connetics corp
  • Stiefel laboratories inc
  • Actavis mid atlantic llc
  • E fougera div altana inc
  • Taro pharmaceuticals inc
  • Teva pharmaceuticals usa
  • Altana inc
  • Stiefel a gsk co
  • Taro pharmaceuticals usa inc
  • Hi tech pharmacal co inc
  • Perrigo co
  • Galderma laboratories l p
  • Nycomed us inc
  • Galderma laboratories inc
  • Tolmar inc
  • Wockhardt eu operations (swiss) ag
  • Galderma laboratories lp
Packagers
Dosage forms
FormRouteStrength
Liquidtopical.05 %
Creamtopical.5 mg/g
Emulsiontopical.5 mg/g
Geltopical.05 mg/g
Geltopical.5 mg/g
Lotiontopical.5 mg/mL
Ointmenttopical.5 mg/g
Solutiontopical.462 mg/mL
Solutiontopical.5 mg/mL
Spraytopical.5 mg/mL
Lotiontopical.05 g/100mL
Lotiontopical.05 mL/100mL
Shampootopical.05 g/100mL
Spraytopical.05 g/mL
Shampootopical0.05 %
Shampootopical.5 mg/mL
Kit
Solutiontopical.4625 mg/mL
Solutiontopical.05 %
Creamtopical.05 %
Ointmenttopical.05 %
Aerosol, foamtopical.5 mg/g
Aerosol, foamtopical0.05 %
Liquidtopical0.05 %
Creamtopical0.05 %
Lotiontopical0.05 %
Ointmenttopical0.05 %
Solutiontopical0.05 %
Prices
Unit descriptionCostUnit
Clobex 0.05% Lotion 118ml Bottle513.56USD bottle
Clobex Spray 0.05% Liquid 125ml Bottle501.7USD bottle
Olux 0.05% Foam 100 gm Can443.77USD can
Olux-E 0.05% Foam 100 gm Can384.32USD can
Olux Olux-E Complete Pack 0.05 & 0.05% Miscellaneous 110 gm Can373.65USD can
Clobex 0.05% Shampoo 118ml Bottle365.67USD bottle
Clobetasol Propionate 0.05% Foam 100 gm Can326.37USD can
Clobex 0.05% Lotion 59ml Bottle280.8USD bottle
Clobex Spray 0.05% Liquid 59ml Bottle278.93USD bottle
Olux 0.05% Foam 50 gm Can239.07USD can
Temovate 0.05% Cream 60 gm Tube234.19USD tube
Temovate 0.05% Gel 60 gm Tube234.19USD tube
Temovate E 0.05% Cream 60 gm Tube234.19USD tube
Clobetasol Propionate 0.05% Foam 50 gm Can177.05USD can
Temovate 0.05% Ointment 30 gm Tube132.55USD tube
Temovate 0.05% Solution 50ml Bottle113.82USD bottle
Temovate 0.05% Cream 45 gm Tube95.43USD tube
Clobetasol Propionate 0.05% Gel 60 gm Tube93.82USD tube
Temovate 0.05% Ointment 15 gm Tube82.1USD tube
Clobetasol 17-prop powder70.74USD g
Clobetasol Propionate 0.05% Cream 60 gm Tube64.15USD tube
Clobetasol Propionate 0.05% Ointment 60 gm Tube64.15USD tube
Clobetasol Propionate 0.05% Gel 30 gm Tube51.66USD tube
Clobetasol Propionate 0.05% Ointment 45 gm Tube50.56USD tube
Clobetasol Propionate 0.05% Cream 45 gm Tube48.57USD tube
Temovate 0.05% Gel 15 gm Tube47.38USD tube
Temovate E 0.05% Cream 15 gm Tube44.9USD tube
Clobetasol Propionate 0.05% Solution 50ml Bottle41.18USD bottle
Clobetasol Propionate 0.05% Cream 30 gm Tube34.79USD tube
Clobetasol Propionate 0.05% Ointment 30 gm Tube34.79USD tube
Clobetasol Propionate 0.05% Gel 15 gm Tube28.86USD tube
Clobetasol Propionate 0.05% Solution 25ml Bottle26.99USD bottle
Clobetasol Propionate 0.05% Cream 15 gm Tube24.94USD tube
Clobetasol Propionate 0.05% Ointment 15 gm Tube24.1USD tube
Olux 0.05% foam6.77USD g
Olux-e 0.05% foam5.9USD g
Clobex 0.05% topical lotion4.58USD ml
Temovate emollient 0.05% crm3.75USD g
Olux-olux-e complete pack3.43USD g
Temovate 0.05% cream3.29USD g
Cormax 0.05% cream2.06USD g
Embeline 0.05% cream1.86USD g
Clobetasol 0.05% cream1.43USD g
Dermovate 0.05 % Cream0.72USD g
Dermovate 0.05 % Ointment0.72USD g
Dermovate 0.05 % Lotion0.63USD g
Mylan-Clobetasol 0.05 % Cream0.38USD g
Mylan-Clobetasol 0.05 % Ointment0.38USD g
Novo-Clobetasol 0.05 % Cream0.38USD g
Novo-Clobetasol 0.05 % Ointment0.38USD g
Pms-Clobetasol 0.05 % Cream0.38USD g
Pms-Clobetasol 0.05 % Ointment0.38USD g
Ratio-Clobetasol 0.05 % Cream0.38USD g
Ratio-Clobetasol 0.05 % Ointment0.38USD g
Taro-Clobetasol 0.05 % Cream0.38USD g
Taro-Clobetasol 0.05 % Ointment0.38USD g
Mylan-Clobetasol 0.05 % Lotion0.33USD g
Pms-Clobetasol 0.05 % Lotion0.33USD g
Ratio-Clobetasol 0.05 % Lotion0.33USD g
Taro-Clobetasol 0.05 % Lotion0.33USD g
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2333427 No2007-01-092019-06-17Canada
CA2333869 No2009-01-062019-09-08Canada
US5972920 No1998-02-122018-02-12Us
US5990100 No1998-03-242018-03-24Us
US6106848 No1997-09-222017-09-22Us
US6126920 No1996-03-012016-03-01Us
US6730288 No1999-09-082019-09-08Us
US7029659 No1999-09-082019-09-08Us
US7316810 No1999-06-172019-06-17Us
US7700081 No2002-01-032022-01-03Us
US8066975 No1999-06-172019-06-17Us
US8066976 No1999-06-172019-06-17Us
US8460641 No2008-11-052028-11-05Us
US8962000 No2005-08-312025-08-31Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point226Elks, J., Phillipps, G.H. and May, P.J.; US. Patent 3,721,687; March 20, 1973; assigned to Glaxo Laboratories Limited, England.
water solubility3.86 mg/LNot Available
logP3.50SANGSTER (1994)
Predicted Properties
PropertyValueSource
Water Solubility0.00413 mg/mLALOGPS
logP3.49ALOGPS
logP4.18ChemAxon
logS-5ALOGPS
pKa (Strongest Acidic)13.63ChemAxon
pKa (Strongest Basic)-3.4ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area80.67 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity119.32 m3·mol-1ChemAxon
Polarizability48.28 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

Elks, J., Phillipps, G.H. and May, P.J.; US. Patent 3,721,687; March 20, 1973; assigned to
Glaxo Laboratories Limited, England.

General ReferencesNot Available
External Links
ATC CodesNot Available
AHFS Codes
  • 84:06.00
PDB EntriesNot Available
FDA labelDownload (95.3 KB)
MSDSDownload (74.6 KB)
Interactions
Drug Interactions
Drug
AldesleukinClobetasol propionate may decrease the antineoplastic activities of Aldesleukin.
CeritinibClobetasol propionate may increase the hyperglycemic activities of Ceritinib.
Corticorelin ovine triflutateThe therapeutic efficacy of Corticorelin can be decreased when used in combination with Clobetasol propionate.
DeferasiroxThe risk or severity of adverse effects can be increased when Clobetasol propionate is combined with Deferasirox.
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Clobetasol propionate.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Zinc ion binding
Specific Function:
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon grow...
Gene Name:
NR3C1
Uniprot ID:
P04150
Molecular Weight:
85658.57 Da
References
  1. Fitzgerald P, O'Brien SM, Scully P, Rijkers K, Scott LV, Dinan TG: Cutaneous glucocorticoid receptor sensitivity and pro-inflammatory cytokine levels in antidepressant-resistant depression. Psychol Med. 2006 Jan;36(1):37-43. Epub 2005 Oct 28. [PubMed:16255837 ]
  2. Hofmann TG, Hehner SP, Bacher S, Droge W, Schmitz ML: Various glucocorticoids differ in their ability to induce gene expression, apoptosis and to repress NF-kappaB-dependent transcription. FEBS Lett. 1998 Dec 28;441(3):441-6. [PubMed:9891987 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Vitamin d 24-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP1A1
Uniprot ID:
P04798
Molecular Weight:
58164.815 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
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Drug created on June 13, 2005 07:24 / Updated on August 24, 2016 01:52