Manidipine: a review of its use in the management of hypertension.
Article Details
- CitationCopy to clipboard
McKeage K, Scott LJ
Manidipine: a review of its use in the management of hypertension.
Drugs. 2004;64(17):1923-40.
- PubMed ID
- 15329044 [ View in PubMed]
- Abstract
Manidipine is a lipophilic, third-generation dihydropyridine calcium channel antagonist with a high degree of selectivity for the vasculature, thereby inducing marked peripheral vasodilation with negligible cardiodepression. In addition, manidipine does not significantly affect norepinephrine levels, suggesting a lack of sympathetic activation. It has a gradual onset of action and a long duration of action enabling once daily administration. Furthermore, manidipine dilates both the efferent and the afferent renal arterioles and appears to have beneficial renal effects unrelated to its antihypertensive effect. Once-daily oral manidipine is an effective and generally well tolerated antihypertensive agent for younger and elderly adult patients with mild-to-moderate hypertension. In particular, in a large double-blind trial, the incidence of ankle oedema was significantly lower in manidipine than in amlodipine recipients. Manidipine is also effective in hypertensive patients with comorbidities, such as type 2 diabetes mellitus and/or renal impairment, and appears to improve insulin sensitivity without affecting metabolic function. Thus, manidipine represents a first-line treatment option for patients with essential mild-to-moderate hypertension.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Manidipine Voltage-dependent L-type calcium channel (Protein Group) Protein group Humans YesBlockerDetails Manidipine Voltage-dependent T-type calcium channel (Protein Group) Protein group Humans YesInhibitorBlockerDetails - Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Manidipine Cytochrome P450 1A1 Protein Humans UnknownInhibitorDetails Manidipine Cytochrome P450 2B6 Protein Humans UnknownInhibitorDetails Manidipine Cytochrome P450 2C19 Protein Humans UnknownInhibitorDetails Manidipine Cytochrome P450 2C9 Protein Humans UnknownInhibitorDetails Manidipine Cytochrome P450 2D6 Protein Humans UnknownInhibitorDetails Manidipine Cytochrome P450 3A4 Protein Humans UnknownSubstrateInhibitorDetails