Identification

Name
Manidipine
Accession Number
DB09238
Type
Small Molecule
Groups
Approved, Investigational
Description

Manidipine (INN) is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive. It is selective for vasculature and does not produce effects on the heart at clinically relevant dosages.

Structure
Thumb
Synonyms
Not Available
International/Other Brands
Caslot / Madipine / Manyper
Categories
UNII
6O4754US88
CAS number
89226-50-6
Weight
Average: 610.711
Monoisotopic: 610.27913496
Chemical Formula
C35H38N4O6
InChI Key
ANEBWFXPVPTEET-UHFFFAOYSA-N
InChI
InChI=1S/C35H38N4O6/c1-24-30(34(40)44-3)32(28-15-10-16-29(23-28)39(42)43)31(25(2)36-24)35(41)45-22-21-37-17-19-38(20-18-37)33(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-16,23,32-33,36H,17-22H2,1-3H3
IUPAC Name
3-{2-[4-(diphenylmethyl)piperazin-1-yl]ethyl} 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
SMILES
COC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)N(=O)=O)C(=O)OCCN1CCN(CC1)C(C1=CC=CC=C1)C1=CC=CC=C1

Pharmacology

Indication

For the treatment of hypertension.

Pharmacodynamics

Manidipine produces vasodilation resulting in lower blood pressure [1].

Mechanism of action

Contraction of vascular smooth muscle is stimulated by Gq coupled receptors which produce calcium release from the sarcoplasmic reticulum. This is followed by opening of voltage dependent calcium channels and an influx of calcium into the cell ultimately producing contraction. Manidipine binds to and dissociates slowly from L- and T-type voltage dependent calcium channels on smooth muscle cells, blocking the entrance of extracellular calcium into the cell and preventing this contraction [1, 2]. This produces vasodilation which decreases blood pressure. Manidipine produces renal vasodilation and an increase in natriuresis. This likely contributes to the antihypertensive effect by reducing blood volume. Manidipine is selective for the vasculature and does not produce significant effects on the heart or central nervous system at clinically relevant dosages.

TargetActionsOrganism
AVoltage dependent L type calcium channel
blocker
Human
AVoltage-dependent T-type calcium channel
blocker
Homo sapiens
Absorption

The median Tmax is 1.5 h [1]. Administration with food produces an 1.3-1.6-fold increase in Cmax but no change in Tmax. Manidipine does not accumulate significantly with multiple doses.

Volume of distribution
Not Available
Protein binding

Manidipine is 99% bound to human plasma proteins [1].

Metabolism

Manidipine is extensively metabolized by CYP enzymes to pyridine derivatives and diphenylmethane derivatives which make up 4-7% and 22-24% of the dose excreted in the urine [1].

Route of elimination

Manidipine is eliminated through extensive metabolism. 63% is eliminated in the feces and 31% in the urine as metabolites [1].

Half life

The half life of elimination has been observed to be dose dependent [1]. Doses of 5, 10, and 20 mg produced half lives of 3.94, 5.02, and 7.95 h respectively.

Clearance
Not Available
Toxicity

The most common adverse events reported in clinical trials were ankle oedema (6%), headache (3.8%), palpitation (2.7%), flushing (2.2%), dizziness (1.6%), rash (0.5%) and fatigue (0.5%) [1].

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
2-HYDROXY-1,4-NAPHTHOQUINONEThe therapeutic efficacy of 2-HYDROXY-1,4-NAPHTHOQUINONE can be increased when used in combination with Manidipine.Experimental
2-mercaptobenzothiazoleThe therapeutic efficacy of 2-mercaptobenzothiazole can be increased when used in combination with Manidipine.Vet Approved
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Manidipine.Experimental, Illicit
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline may increase the hypotensive activities of Manidipine.Experimental
AcebutololAcebutolol may increase the hypotensive activities of Manidipine.Approved, Investigational
AceclofenacThe metabolism of Aceclofenac can be decreased when combined with Manidipine.Approved, Investigational
AcemetacinThe therapeutic efficacy of Manidipine can be decreased when used in combination with Acemetacin.Approved, Experimental, Investigational
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Manidipine.Approved, Investigational
AcepromazineThe risk or severity of hypotension can be increased when Acepromazine is combined with Manidipine.Approved, Vet Approved
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Manidipine.Approved
Acetyl sulfisoxazoleThe metabolism of Acetyl sulfisoxazole can be decreased when combined with Manidipine.Approved, Vet Approved
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Manidipine.Approved
Acetylsalicylic acidThe metabolism of Acetylsalicylic acid can be decreased when combined with Manidipine.Approved, Vet Approved
AjmalineThe metabolism of Ajmaline can be decreased when combined with Manidipine.Approved, Investigational
AlfuzosinAlfuzosin may increase the hypotensive activities of Manidipine.Approved, Investigational
AliskirenAliskiren may increase the hypotensive activities of Manidipine.Approved, Investigational
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Manidipine.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Manidipine.Approved
AlosetronThe metabolism of Alosetron can be decreased when combined with Manidipine.Approved, Withdrawn
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Manidipine.Approved, Illicit, Investigational
AlprenololAlprenolol may increase the hypotensive activities of Manidipine.Approved, Withdrawn
AmbrisentanManidipine may increase the hypotensive activities of Ambrisentan.Approved, Investigational
AmifostineManidipine may increase the hypotensive activities of Amifostine.Approved, Investigational
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Manidipine.Approved, Withdrawn
AmiodaroneThe metabolism of Amiodarone can be decreased when combined with Manidipine.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Manidipine.Approved
AmlodipineAmlodipine may increase the hypotensive activities of Manidipine.Approved
AmobarbitalThe metabolism of Manidipine can be increased when combined with Amobarbital.Approved, Illicit
AmorolfineThe therapeutic efficacy of Amorolfine can be increased when used in combination with Manidipine.Approved, Investigational
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Manidipine.Approved
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Manidipine.Approved, Illicit, Investigational
Amphotericin BThe therapeutic efficacy of Amphotericin B can be increased when used in combination with Manidipine.Approved, Investigational
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Manidipine.Approved, Investigational
AmsacrineThe metabolism of Amsacrine can be decreased when combined with Manidipine.Approved, Investigational
AnidulafunginThe therapeutic efficacy of Anidulafungin can be increased when used in combination with Manidipine.Approved, Investigational
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Manidipine.Approved, Investigational
ApixabanThe metabolism of Apixaban can be decreased when combined with Manidipine.Approved
AprindineThe metabolism of Aprindine can be decreased when combined with Manidipine.Approved
Arachidonic AcidThe metabolism of Arachidonic Acid can be decreased when combined with Manidipine.Experimental
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Manidipine.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Manidipine.Approved, Investigational
ArotinololThe risk or severity of hypotension, conduction block, and bradycardia can be increased when Arotinolol is combined with Manidipine.Investigational
ArtemetherThe metabolism of Artemether can be decreased when combined with Manidipine.Approved
AsenapineThe risk or severity of hypotension can be increased when Asenapine is combined with Manidipine.Approved
AstemizoleThe metabolism of Astemizole can be decreased when combined with Manidipine.Approved, Withdrawn
AsunaprevirThe serum concentration of Asunaprevir can be increased when it is combined with Manidipine.Approved, Investigational, Withdrawn
AtazanavirThe metabolism of Atazanavir can be decreased when combined with Manidipine.Approved, Investigational
AtenololAtenolol may increase the hypotensive activities of Manidipine.Approved
AtomoxetineThe metabolism of Atomoxetine can be decreased when combined with Manidipine.Approved
AtorvastatinThe risk or severity of adverse effects can be increased when Manidipine is combined with Atorvastatin.Approved
AvanafilAvanafil may increase the antihypertensive activities of Manidipine.Approved
AvatrombopagThe metabolism of Avatrombopag can be decreased when combined with Manidipine.Approved, Investigational
AzelastineThe metabolism of Azelastine can be decreased when combined with Manidipine.Approved
Bafilomycin A1The therapeutic efficacy of Bafilomycin A1 can be increased when used in combination with Manidipine.Experimental
BarbexacloneThe metabolism of Manidipine can be increased when combined with Barbexaclone.Experimental
BarbitalThe metabolism of Manidipine can be increased when combined with Barbital.Illicit
BarnidipineManidipine may increase the antihypertensive activities of Barnidipine.Approved
BenazeprilBenazepril may increase the hypotensive activities of Manidipine.Approved, Investigational
BendroflumethiazideBendroflumethiazide may increase the hypotensive activities of Manidipine.Approved
BenmoxinBenmoxin may increase the hypotensive activities of Manidipine.Withdrawn
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Manidipine.Approved
Benzoic AcidThe therapeutic efficacy of Benzoic Acid can be increased when used in combination with Manidipine.Approved, Investigational
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Manidipine.Approved
BepridilBepridil may increase the hypotensive activities of Manidipine.Approved, Withdrawn
BetaxololBetaxolol may increase the hypotensive activities of Manidipine.Approved, Investigational
BethanidineBethanidine may increase the hypotensive activities of Manidipine.Approved
BevantololThe risk or severity of hypotension can be increased when Bevantolol is combined with Manidipine.Approved
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Manidipine.Approved, Investigational
BietaserpineBietaserpine may increase the hypotensive activities of Manidipine.Experimental
BifonazoleThe therapeutic efficacy of Bifonazole can be increased when used in combination with Manidipine.Approved, Investigational
BimatoprostBimatoprost may increase the hypotensive activities of Manidipine.Approved, Investigational
BioallethrinThe metabolism of Bioallethrin can be decreased when combined with Manidipine.Approved, Experimental
BisoprololBisoprolol may increase the hypotensive activities of Manidipine.Approved
BortezomibThe metabolism of Bortezomib can be decreased when combined with Manidipine.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Manidipine.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Manidipine.Approved
BQ-123Manidipine may increase the hypotensive activities of BQ-123.Investigational
Brefeldin AThe therapeutic efficacy of Brefeldin A can be increased when used in combination with Manidipine.Experimental
BretyliumBretylium may increase the hypotensive activities of Manidipine.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Manidipine.Approved, Investigational
BrimonidineBrimonidine may increase the antihypertensive activities of Manidipine.Approved
BrivaracetamThe metabolism of Brivaracetam can be decreased when combined with Manidipine.Approved, Investigational
BrofaromineBrofaromine may increase the hypotensive activities of Manidipine.Experimental
BromocriptineThe risk or severity of adverse effects can be increased when Bromocriptine is combined with Manidipine.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Manidipine.Approved
BucindololThe risk or severity of hypotension can be increased when Bucindolol is combined with Manidipine.Investigational
BufuralolThe metabolism of Bufuralol can be decreased when combined with Manidipine.Experimental, Investigational
BunazosinThe risk or severity of hypotension can be increased when Bunazosin is combined with Manidipine.Investigational
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Manidipine.Approved, Investigational
BupranololBupranolol may increase the hypotensive activities of Manidipine.Approved
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Manidipine.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be decreased when combined with Manidipine.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Manidipine.Approved, Investigational
ButenafineThe therapeutic efficacy of Butenafine can be increased when used in combination with Manidipine.Approved
ButoconazoleThe therapeutic efficacy of Butoconazole can be increased when used in combination with Manidipine.Approved
CabergolineThe risk or severity of adverse effects can be increased when Cabergoline is combined with Manidipine.Approved
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Manidipine.Approved, Investigational
CadralazineCadralazine may increase the hypotensive activities of Manidipine.Experimental
CafedrineManidipine may increase the hypotensive activities of Cafedrine.Investigational
CaffeineThe metabolism of Caffeine can be decreased when combined with Manidipine.Approved
Calcium AcetateThe therapeutic efficacy of Manidipine can be decreased when used in combination with Calcium Acetate.Approved, Investigational
Calcium CarbonateThe therapeutic efficacy of Manidipine can be decreased when used in combination with Calcium Carbonate.Approved, Investigational
Calcium ChlorideThe therapeutic efficacy of Manidipine can be decreased when used in combination with Calcium Chloride.Approved
Calcium CitrateThe therapeutic efficacy of Manidipine can be decreased when used in combination with Calcium Citrate.Approved
Calcium glubionateThe therapeutic efficacy of Manidipine can be decreased when used in combination with Calcium glubionate.Approved
Calcium GluceptateThe therapeutic efficacy of Manidipine can be decreased when used in combination with Calcium Gluceptate.Approved
Calcium gluconateThe therapeutic efficacy of Manidipine can be decreased when used in combination with Calcium gluconate.Approved, Vet Approved
Calcium lactateThe therapeutic efficacy of Manidipine can be decreased when used in combination with Calcium lactate.Approved, Investigational, Vet Approved
Calcium lactate gluconateThe therapeutic efficacy of Manidipine can be decreased when used in combination with Calcium lactate gluconate.Experimental
Calcium levulinateThe therapeutic efficacy of Manidipine can be decreased when used in combination with Calcium levulinate.Approved, Experimental
Calcium pangamateThe therapeutic efficacy of Manidipine can be decreased when used in combination with Calcium pangamate.Experimental
Calcium PhosphateThe therapeutic efficacy of Manidipine can be decreased when used in combination with Calcium Phosphate.Approved
CandesartanThe metabolism of Candesartan can be decreased when combined with Manidipine.Experimental
Candesartan cilexetilCandesartan cilexetil may increase the hypotensive activities of Manidipine.Approved
CandicidinThe therapeutic efficacy of Candicidin can be increased when used in combination with Manidipine.Withdrawn
CandoxatrilCandoxatril may increase the hypotensive activities of Manidipine.Experimental
CannabidiolThe metabolism of Cannabidiol can be decreased when combined with Manidipine.Approved, Investigational
Capric acidThe therapeutic efficacy of Capric acid can be increased when used in combination with Manidipine.Experimental
CaptoprilCaptopril may increase the hypotensive activities of Manidipine.Approved
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Manidipine.Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Manidipine.Approved, Investigational
CaroxazoneCaroxazone may increase the hypotensive activities of Manidipine.Withdrawn
CarteololCarteolol may increase the hypotensive activities of Manidipine.Approved
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Manidipine.Approved, Investigational
CaseinThe therapeutic efficacy of Manidipine can be decreased when used in combination with Casein.Approved
CaspofunginThe therapeutic efficacy of Caspofungin can be increased when used in combination with Manidipine.Approved
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Manidipine.Approved, Investigational
CeliprololCeliprolol may increase the hypotensive activities of Manidipine.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Manidipine.Approved, Investigational, Vet Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Manidipine.Approved, Withdrawn
CeruleninThe therapeutic efficacy of Cerulenin can be increased when used in combination with Manidipine.Approved
CevimelineThe metabolism of Cevimeline can be decreased when combined with Manidipine.Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Manidipine.Approved, Illicit, Investigational
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Manidipine.Approved, Investigational, Vet Approved
ChlorothiazideChlorothiazide may increase the hypotensive activities of Manidipine.Approved, Vet Approved
ChloroxineThe therapeutic efficacy of Chloroxine can be increased when used in combination with Manidipine.Approved
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Manidipine.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Manidipine.Approved, Investigational, Vet Approved
ChlorpropamideThe metabolism of Chlorpropamide can be decreased when combined with Manidipine.Approved, Investigational
ChlorthalidoneChlorthalidone may increase the hypotensive activities of Manidipine.Approved
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Manidipine.Approved
CicletanineManidipine may increase the hypotensive activities of Cicletanine.Investigational
CiclopiroxThe therapeutic efficacy of Ciclopirox can be increased when used in combination with Manidipine.Approved, Investigational
CilazaprilCilazapril may increase the hypotensive activities of Manidipine.Approved
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Manidipine.Approved, Investigational
CimetidineThe serum concentration of Manidipine can be increased when it is combined with Cimetidine.Approved, Investigational
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Manidipine.Approved, Investigational
CisaprideThe metabolism of Cisapride can be decreased when combined with Manidipine.Approved, Investigational, Withdrawn
CitalopramThe metabolism of Citalopram can be decreased when combined with Manidipine.Approved
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Manidipine.Approved, Investigational
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Manidipine.Approved, Investigational, Vet Approved
ClonidineClonidine may increase the hypotensive activities of Manidipine.Approved
ClopidogrelThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Manidipine.Approved
CloranololManidipine may increase the hypotensive activities of Cloranolol.Experimental
ClotrimazoleThe therapeutic efficacy of Clotrimazole can be increased when used in combination with Manidipine.Approved, Vet Approved
ClozapineThe metabolism of Clozapine can be decreased when combined with Manidipine.Approved
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Manidipine.Approved, Illicit
CordycepinThe therapeutic efficacy of Cordycepin can be increased when used in combination with Manidipine.Investigational
CryptenamineCryptenamine may increase the hypotensive activities of Manidipine.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Manidipine.Approved
CyclopenthiazideManidipine may increase the hypotensive activities of Cyclopenthiazide.Experimental
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Manidipine.Approved, Investigational
CyclosporineThe therapeutic efficacy of Cyclosporine can be increased when used in combination with Manidipine.Approved, Investigational, Vet Approved
CyclothiazideCyclothiazide may increase the hypotensive activities of Manidipine.Approved
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Manidipine.Approved
DapiprazoleThe risk or severity of hypotension can be increased when Dapiprazole is combined with Manidipine.Approved
DapsoneThe metabolism of Dapsone can be decreased when combined with Manidipine.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Manidipine.Approved, Investigational
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Manidipine.Approved
DebrisoquinDebrisoquin may increase the hypotensive activities of Manidipine.Approved, Investigational
DelaprilManidipine may increase the hypotensive activities of Delapril.Investigational
DelavirdineThe metabolism of Delavirdine can be decreased when combined with Manidipine.Approved
DeserpidineManidipine may increase the hypotensive activities of Deserpidine.Approved
DesipramineThe metabolism of Desipramine can be decreased when combined with Manidipine.Approved, Investigational
DeutetrabenazineThe metabolism of Deutetrabenazine can be decreased when combined with Manidipine.Approved, Investigational
Dexchlorpheniramine maleateThe metabolism of Dexchlorpheniramine maleate can be decreased when combined with Manidipine.Approved
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Manidipine.Approved, Illicit, Investigational, Withdrawn
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Manidipine.Approved, Investigational
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Manidipine.Approved, Illicit
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Manidipine.Approved
DiazepamThe metabolism of Diazepam can be decreased when combined with Manidipine.Approved, Illicit, Investigational, Vet Approved
DiazoxideDiazoxide may increase the hypotensive activities of Manidipine.Approved
DichloropheneThe therapeutic efficacy of Dichlorophene can be increased when used in combination with Manidipine.Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Manidipine.Approved, Vet Approved
DicoumarolThe metabolism of Dicoumarol can be decreased when combined with Manidipine.Approved
DiethylnorspermineDiethylnorspermine may increase the hypotensive activities of Manidipine.Investigational
DihydralazineDihydralazine may increase the hypotensive activities of Manidipine.Approved, Investigational
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Manidipine.Approved, Illicit
DihydroergocornineThe risk or severity of adverse effects can be increased when Dihydroergocornine is combined with Manidipine.Approved
DihydroergocristineThe risk or severity of adverse effects can be increased when Dihydroergocristine is combined with Manidipine.Approved, Experimental
DihydroergocryptineThe risk or severity of adverse effects can be increased when Dihydroergocryptine is combined with Manidipine.Experimental
DihydroergotamineThe risk or severity of adverse effects can be increased when Dihydroergotamine is combined with Manidipine.Approved, Investigational
DiltiazemDiltiazem may increase the hypotensive activities of Manidipine.Approved, Investigational
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Manidipine.Approved, Investigational
DipyridamoleDipyridamole may increase the antihypertensive activities of Manidipine.Approved
DoconexentThe metabolism of Doconexent can be decreased when combined with Manidipine.Approved, Investigational
DolasetronThe metabolism of Dolasetron can be decreased when combined with Manidipine.Approved, Investigational
DomperidoneThe metabolism of Domperidone can be decreased when combined with Manidipine.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Manidipine.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Manidipine.Approved
DorzolamideDorzolamide may increase the hypotensive activities of Manidipine.Approved
DoxazosinDoxazosin may increase the hypotensive activities of Manidipine.Approved
DoxepinThe metabolism of Doxepin can be decreased when combined with Manidipine.Approved, Investigational
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Manidipine.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Manidipine.Approved, Investigational
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Manidipine.Approved, Illicit
DronedaroneThe metabolism of Dronedarone can be decreased when combined with Manidipine.Approved
DroperidolThe risk or severity of hypotension can be increased when Droperidol is combined with Manidipine.Approved, Vet Approved
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Manidipine.Approved
EconazoleThe therapeutic efficacy of Econazole can be increased when used in combination with Manidipine.Approved
EfavirenzThe serum concentration of Manidipine can be decreased when it is combined with Efavirenz.Approved, Investigational
EfinaconazoleThe therapeutic efficacy of Efinaconazole can be increased when used in combination with Manidipine.Approved
EfonidipineEfonidipine may increase the hypotensive activities of Manidipine.Approved, Investigational
EletriptanThe metabolism of Eletriptan can be decreased when combined with Manidipine.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Manidipine.Approved
EnalaprilEnalapril may increase the hypotensive activities of Manidipine.Approved, Vet Approved
EnalaprilatManidipine may increase the hypotensive activities of Enalaprilat.Approved
EnasidenibThe metabolism of Enasidenib can be decreased when combined with Manidipine.Approved, Investigational
EncainideThe metabolism of Encainide can be decreased when combined with Manidipine.Approved, Investigational, Withdrawn
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Manidipine.Investigational
EndralazineEndralazine may increase the hypotensive activities of Manidipine.Experimental
EpanololManidipine may increase the hypotensive activities of Epanolol.Experimental
EpinastineThe metabolism of Epinastine can be decreased when combined with Manidipine.Approved, Investigational
EpinephrineThe risk or severity of hypotension can be increased when Epinephrine is combined with Manidipine.Approved, Vet Approved
EpoprostenolEpoprostenol may increase the hypotensive activities of Manidipine.Approved
EprosartanEprosartan may increase the hypotensive activities of Manidipine.Approved
ErgonovineThe risk or severity of adverse effects can be increased when Ergonovine is combined with Manidipine.Approved
ErgotamineThe risk or severity of adverse effects can be increased when Ergotamine is combined with Manidipine.Approved
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Manidipine.Approved, Investigational
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Manidipine.Approved, Investigational
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Manidipine.Investigational
EstradiolThe metabolism of Estradiol can be decreased when combined with Manidipine.Approved, Investigational, Vet Approved
Estradiol acetateThe metabolism of Estradiol acetate can be decreased when combined with Manidipine.Approved, Investigational, Vet Approved
Estradiol benzoateThe metabolism of Estradiol benzoate can be decreased when combined with Manidipine.Approved, Investigational, Vet Approved
Estradiol cypionateThe metabolism of Estradiol cypionate can be decreased when combined with Manidipine.Approved, Investigational, Vet Approved
Estradiol dienanthateThe metabolism of Estradiol dienanthate can be decreased when combined with Manidipine.Approved, Investigational, Vet Approved
Estradiol valerateThe metabolism of Estradiol valerate can be decreased when combined with Manidipine.Approved, Investigational, Vet Approved
EstroneThe metabolism of Estrone can be decreased when combined with Manidipine.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Manidipine.Approved, Investigational
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Manidipine.Approved, Illicit
EtodolacThe metabolism of Etodolac can be decreased when combined with Manidipine.Approved, Investigational, Vet Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Manidipine.Approved, Investigational
EtravirineThe metabolism of Etravirine can be decreased when combined with Manidipine.Approved
FelodipineFelodipine may increase the hypotensive activities of Manidipine.Approved, Investigational
FenoldopamFenoldopam may increase the hypotensive activities of Manidipine.Approved
FenticonazoleThe therapeutic efficacy of Fenticonazole can be increased when used in combination with Manidipine.Experimental
Ferulic acidFerulic acid may increase the hypotensive activities of Manidipine.Experimental
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Manidipine.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Manidipine.Approved, Investigational
FlecainideThe metabolism of Flecainide can be decreased when combined with Manidipine.Approved, Withdrawn
FluconazoleThe therapeutic efficacy of Fluconazole can be increased when used in combination with Manidipine.Approved, Investigational
FlucytosineThe therapeutic efficacy of Flucytosine can be increased when used in combination with Manidipine.Approved, Investigational
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Manidipine.Approved
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Manidipine.Approved, Illicit
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Manidipine.Approved, Vet Approved
FlupentixolThe risk or severity of hypotension can be increased when Flupentixol is combined with Manidipine.Approved, Investigational, Withdrawn
FluphenazineThe metabolism of Fluphenazine can be decreased when combined with Manidipine.Approved
FlurbiprofenThe metabolism of Flurbiprofen can be decreased when combined with Manidipine.Approved, Investigational
FlutrimazoleThe therapeutic efficacy of Flutrimazole can be increased when used in combination with Manidipine.Experimental
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Manidipine.Approved
FluvoxamineThe metabolism of Fluvoxamine can be decreased when combined with Manidipine.Approved, Investigational
FormoterolThe metabolism of Formoterol can be decreased when combined with Manidipine.Approved, Investigational
FosinoprilFosinopril may increase the hypotensive activities of Manidipine.Approved
FosphenytoinThe metabolism of Fosphenytoin can be decreased when combined with Manidipine.Approved, Investigational
FostamatinibFostamatinib may increase the antihypertensive activities of Manidipine.Approved, Investigational
FurazolidoneFurazolidone may increase the hypotensive activities of Manidipine.Approved, Investigational, Vet Approved
GalantamineThe metabolism of Galantamine can be decreased when combined with Manidipine.Approved
GavestinelThe metabolism of Gavestinel can be decreased when combined with Manidipine.Investigational
GefitinibThe metabolism of Gefitinib can be decreased when combined with Manidipine.Approved, Investigational
GliclazideThe metabolism of Gliclazide can be decreased when combined with Manidipine.Approved
GlimepirideThe metabolism of Glimepiride can be decreased when combined with Manidipine.Approved
GlipizideThe metabolism of Glipizide can be decreased when combined with Manidipine.Approved, Investigational
GlyburideThe metabolism of Glyburide can be decreased when combined with Manidipine.Approved
GlyphosateThe therapeutic efficacy of Glyphosate can be increased when used in combination with Manidipine.Experimental
GranisetronThe metabolism of Granisetron can be decreased when combined with Manidipine.Approved, Investigational
GriseofulvinThe therapeutic efficacy of Griseofulvin can be increased when used in combination with Manidipine.Approved, Investigational, Vet Approved
GuanabenzGuanabenz may increase the hypotensive activities of Manidipine.Approved, Investigational
GuanadrelGuanadrel may increase the hypotensive activities of Manidipine.Approved
GuanazodineManidipine may increase the hypotensive activities of Guanazodine.Experimental
GuanethidineGuanethidine may increase the hypotensive activities of Manidipine.Approved
GuanfacineGuanfacine may increase the hypotensive activities of Manidipine.Approved, Investigational
GuanoclorManidipine may increase the hypotensive activities of Guanoclor.Experimental
GuanoxabenzManidipine may increase the hypotensive activities of Guanoxabenz.Experimental
GuanoxanManidipine may increase the hypotensive activities of Guanoxan.Experimental
HachimycinThe therapeutic efficacy of Hachimycin can be increased when used in combination with Manidipine.Experimental
HalofantrineThe metabolism of Halofantrine can be decreased when combined with Manidipine.Approved
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Manidipine.Approved
HaloproginThe therapeutic efficacy of Haloprogin can be increased when used in combination with Manidipine.Approved, Withdrawn
HalothaneThe metabolism of Halothane can be decreased when combined with Manidipine.Approved, Vet Approved
HarmalineHarmaline may increase the hypotensive activities of Manidipine.Experimental
HexamethoniumHexamethonium may increase the hypotensive activities of Manidipine.Experimental
HexetidineThe therapeutic efficacy of Hexetidine can be increased when used in combination with Manidipine.Approved, Investigational
HexobarbitalThe metabolism of Manidipine can be increased when combined with Hexobarbital.Approved
HistamineThe metabolism of Histamine can be decreased when combined with Manidipine.Approved, Investigational
HydracarbazineHydracarbazine may increase the hypotensive activities of Manidipine.Experimental
HydralazineHydralazine may increase the hypotensive activities of Manidipine.Approved
HydrochlorothiazideHydrochlorothiazide may increase the hypotensive activities of Manidipine.Approved, Vet Approved
HydrocodoneThe metabolism of Hydrocodone can be decreased when combined with Manidipine.Approved, Illicit
HydroflumethiazideHydroflumethiazide may increase the hypotensive activities of Manidipine.Approved, Investigational
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Manidipine.Approved, Illicit
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Manidipine.Approved
IbuprofenThe metabolism of Ibuprofen can be decreased when combined with Manidipine.Approved
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Manidipine.Approved
IfosfamideThe metabolism of Ifosfamide can be decreased when combined with Manidipine.Approved
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Manidipine.Approved
IloprostIloprost may increase the hypotensive activities of Manidipine.Approved, Investigational
ImatinibThe metabolism of Imatinib can be decreased when combined with Manidipine.Approved
ImidaprilManidipine may increase the hypotensive activities of Imidapril.Investigational
ImipramineThe metabolism of Imipramine can be decreased when combined with Manidipine.Approved
IndapamideIndapamide may increase the hypotensive activities of Manidipine.Approved
IndenololIndenolol may increase the hypotensive activities of Manidipine.Withdrawn
IndisulamThe metabolism of Indisulam can be decreased when combined with Manidipine.Investigational
IndomethacinThe metabolism of Indomethacin can be decreased when combined with Manidipine.Approved, Investigational
IndoraminIndoramin may increase the hypotensive activities of Manidipine.Withdrawn
IpecacThe metabolism of Ipecac can be decreased when combined with Manidipine.Approved, Withdrawn
IpratropiumThe metabolism of Ipratropium bromide can be decreased when combined with Manidipine.Approved
IproclozideIproclozide may increase the hypotensive activities of Manidipine.Withdrawn
IproniazidIproniazid may increase the hypotensive activities of Manidipine.Withdrawn
IrbesartanIrbesartan may increase the hypotensive activities of Manidipine.Approved, Investigational
IsocarboxazidIsocarboxazid may increase the hypotensive activities of Manidipine.Approved
IsoconazoleThe therapeutic efficacy of Isoconazole can be increased when used in combination with Manidipine.Approved
IsradipineIsradipine may increase the hypotensive activities of Manidipine.Approved, Investigational
ItraconazoleThe therapeutic efficacy of Itraconazole can be increased when used in combination with Manidipine.Approved, Investigational
IxazomibThe metabolism of Ixazomib can be decreased when combined with Manidipine.Approved, Investigational
KetamineThe metabolism of Ketamine can be decreased when combined with Manidipine.Approved, Vet Approved
KetanserinKetanserin may increase the hypotensive activities of Manidipine.Investigational
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Manidipine.Approved, Investigational
KetoconazoleThe therapeutic efficacy of Ketoconazole can be increased when used in combination with Manidipine.Approved, Investigational
KetoprofenThe metabolism of Ketoprofen can be decreased when combined with Manidipine.Approved, Vet Approved
LabetalolLabetalol may increase the hypotensive activities of Manidipine.Approved
LacidipineLacidipine may increase the hypotensive activities of Manidipine.Approved, Investigational
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Manidipine.Approved, Investigational
LatanoprostLatanoprost may increase the hypotensive activities of Manidipine.Approved, Investigational
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Manidipine.Approved, Investigational
LercanidipineLercanidipine may increase the hypotensive activities of Manidipine.Approved, Investigational
LesinuradThe metabolism of Lesinurad can be decreased when combined with Manidipine.Approved, Investigational
LetermovirThe metabolism of Letermovir can be decreased when combined with Manidipine.Approved, Investigational
LevodopaThe metabolism of Levodopa can be decreased when combined with Manidipine.Approved
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Manidipine.Approved, Investigational
LicofeloneThe metabolism of Licofelone can be decreased when combined with Manidipine.Investigational
LidocaineThe metabolism of Lidocaine can be decreased when combined with Manidipine.Approved, Vet Approved
LinsidomineManidipine may increase the hypotensive activities of Linsidomine.Experimental
LisdexamfetamineThe risk or severity of hypotension can be increased when Lisdexamfetamine is combined with Manidipine.Approved, Investigational
LisinoprilLisinopril may increase the hypotensive activities of Manidipine.Approved, Investigational
LisurideThe risk or severity of adverse effects can be increased when Lisuride is combined with Manidipine.Approved, Investigational
LofexidineLofexidine may increase the hypotensive activities of Manidipine.Approved, Investigational
LomustineThe metabolism of Lomustine can be decreased when combined with Manidipine.Approved, Investigational
LoperamideThe metabolism of Loperamide can be decreased when combined with Manidipine.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Manidipine.Approved, Investigational
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Manidipine.Approved
LornoxicamThe metabolism of Lornoxicam can be decreased when combined with Manidipine.Approved, Investigational
LorpiprazoleThe metabolism of Lorpiprazole can be decreased when combined with Manidipine.Approved
LosartanLosartan may increase the hypotensive activities of Manidipine.Approved
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Manidipine.Approved, Investigational
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Manidipine.Approved, Investigational
Lysergic Acid DiethylamideThe risk or severity of adverse effects can be increased when Lysergic Acid Diethylamide is combined with Manidipine.Illicit, Investigational, Withdrawn
MacitentanManidipine may increase the hypotensive activities of Macitentan.Approved
Magnesium hydroxideThe risk or severity of hypotension and neuromuscular blockade can be increased when Manidipine is combined with Magnesium hydroxide.Approved, Investigational
Magnesium oxideThe risk or severity of hypotension and neuromuscular blockade can be increased when Manidipine is combined with Magnesium oxide.Approved
Magnesium salicylateThe risk or severity of hypotension and neuromuscular blockade can be increased when Manidipine is combined with Magnesium salicylate.Approved
Magnesium sulfateThe risk or severity of hypotension and neuromuscular blockade can be increased when Manidipine is combined with Magnesium sulfate.Approved, Investigational, Vet Approved
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Manidipine.Approved, Investigational
MebanazineMebanazine may increase the hypotensive activities of Manidipine.Withdrawn
MecamylamineMecamylamine may increase the hypotensive activities of Manidipine.Approved, Investigational
Medical CannabisThe metabolism of Medical Cannabis can be decreased when combined with Manidipine.Experimental, Investigational
Mefenamic acidThe metabolism of Mefenamic acid can be decreased when combined with Manidipine.Approved
MelatoninThe metabolism of Melatonin can be decreased when combined with Manidipine.Approved, Nutraceutical, Vet Approved
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Manidipine.Approved, Vet Approved
MepartricinThe therapeutic efficacy of Mepartricin can be increased when used in combination with Manidipine.Experimental
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Manidipine.Investigational, Withdrawn
MequitazineThe metabolism of Mequitazine can be decreased when combined with Manidipine.Approved
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Manidipine.Approved, Investigational
MestranolThe metabolism of Mestranol can be decreased when combined with Manidipine.Approved
MetergolineThe risk or severity of adverse effects can be increased when Metergoline is combined with Manidipine.Experimental
MethadoneThe metabolism of Methadone can be decreased when combined with Manidipine.Approved
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Manidipine.Approved, Illicit
MethohexitalThe metabolism of Manidipine can be increased when combined with Methohexital.Approved
MethoserpidineManidipine may increase the hypotensive activities of Methoserpidine.Experimental
MethotrimeprazineThe metabolism of Methotrimeprazine can be decreased when combined with Manidipine.Approved, Investigational
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Manidipine.Approved, Investigational, Vet Approved
MethyldopaMethyldopa may increase the hypotensive activities of Manidipine.Approved
Methylene blueMethylene blue may increase the hypotensive activities of Manidipine.Approved, Investigational
MethylergometrineThe risk or severity of adverse effects can be increased when Methylergometrine is combined with Manidipine.Approved
MethylphenidateMethylphenidate may decrease the antihypertensive activities of Manidipine.Approved, Investigational
MethylphenobarbitalThe metabolism of Manidipine can be increased when combined with Methylphenobarbital.Approved
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Manidipine.Approved, Illicit, Withdrawn
MethysergideThe risk or severity of adverse effects can be increased when Methysergide is combined with Manidipine.Approved
MetipranololMetipranolol may increase the hypotensive activities of Manidipine.Approved
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Manidipine.Approved, Investigational
MetolazoneMetolazone may increase the hypotensive activities of Manidipine.Approved
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Manidipine.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Manidipine.Approved
MetyrosineManidipine may increase the hypotensive activities of Metyrosine.Approved
MevastatinThe serum concentration of Mevastatin can be increased when it is combined with Manidipine.Experimental
MexiletineThe metabolism of Mexiletine can be decreased when combined with Manidipine.Approved, Investigational
MianserinThe metabolism of Mianserin can be decreased when combined with Manidipine.Approved, Investigational
MibefradilMibefradil may increase the hypotensive activities of Manidipine.Investigational, Withdrawn
MicafunginThe therapeutic efficacy of Micafungin can be increased when used in combination with Manidipine.Approved, Investigational
MiconazoleThe therapeutic efficacy of Miconazole can be increased when used in combination with Manidipine.Approved, Investigational, Vet Approved
MiltefosineThe therapeutic efficacy of Miltefosine can be increased when used in combination with Manidipine.Approved, Investigational
MinaprineMinaprine may increase the hypotensive activities of Manidipine.Approved
MinoxidilMinoxidil may increase the hypotensive activities of Manidipine.Approved, Investigational
MirabegronThe metabolism of Mirabegron can be decreased when combined with Manidipine.Approved
MirodenafilMirodenafil may increase the antihypertensive activities of Manidipine.Investigational
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Manidipine.Approved
MoclobemideMoclobemide may increase the hypotensive activities of Manidipine.Approved, Investigational
MoexiprilMoexipril may increase the hypotensive activities of Manidipine.Approved
MolsidomineMolsidomine may increase the hypotensive activities of Manidipine.Approved, Investigational
MonensinThe therapeutic efficacy of Monensin can be increased when used in combination with Manidipine.Vet Approved
MontelukastThe metabolism of Montelukast can be decreased when combined with Manidipine.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Manidipine.Approved, Investigational
MoxonidineMoxonidine may increase the hypotensive activities of Manidipine.Approved, Investigational
MuzolimineManidipine may increase the hypotensive activities of Muzolimine.Experimental
MyxothiazolThe therapeutic efficacy of Myxothiazol can be increased when used in combination with Manidipine.Experimental
NabiximolsThe metabolism of Nabiximols can be decreased when combined with Manidipine.Approved, Investigational
NadololNadolol may increase the hypotensive activities of Manidipine.Approved
NafcillinThe therapeutic efficacy of Manidipine can be decreased when used in combination with Nafcillin.Approved, Investigational
NaftifineThe therapeutic efficacy of Naftifine can be increased when used in combination with Manidipine.Approved
NaftopidilManidipine may increase the hypotensive activities of Naftopidil.Investigational
NaproxenThe metabolism of Naproxen can be decreased when combined with Manidipine.Approved, Vet Approved
NatamycinThe therapeutic efficacy of Natamycin can be increased when used in combination with Manidipine.Approved
NateglinideThe metabolism of Nateglinide can be decreased when combined with Manidipine.Approved, Investigational
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Manidipine.Approved, Investigational
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Manidipine.Approved, Withdrawn
NetupitantThe metabolism of Netupitant can be decreased when combined with Manidipine.Approved, Investigational
NevirapineThe metabolism of Nevirapine can be decreased when combined with Manidipine.Approved
NialamideNialamide may increase the hypotensive activities of Manidipine.Withdrawn
NicardipineNicardipine may increase the hypotensive activities of Manidipine.Approved, Investigational
NicergolineThe risk or severity of adverse effects can be increased when Nicergoline is combined with Manidipine.Approved, Investigational
NiclosamideThe metabolism of Niclosamide can be decreased when combined with Manidipine.Approved, Investigational, Vet Approved
NicorandilNicorandil may increase the hypotensive activities of Manidipine.Approved, Investigational
NicotineThe metabolism of Nicotine can be decreased when combined with Manidipine.Approved
NifedipineThe metabolism of Nifedipine can be decreased when combined with Manidipine.Approved
NifuratelThe therapeutic efficacy of Nifuratel can be increased when used in combination with Manidipine.Experimental
NiguldipineManidipine may increase the hypotensive activities of Niguldipine.Experimental
Nikkomycin ZThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Manidipine.Investigational
NilvadipineNilvadipine may increase the hypotensive activities of Manidipine.Approved, Investigational
NimodipineNimodipine may increase the hypotensive activities of Manidipine.Approved, Investigational
NisoldipineNisoldipine may increase the hypotensive activities of Manidipine.Approved
NitrendipineNitrendipine may increase the hypotensive activities of Manidipine.Approved, Investigational
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Manidipine.Approved, Investigational, Vet Approved
NitroprussideManidipine may increase the hypotensive activities of Nitroprusside.Approved, Investigational
NitroxolineThe therapeutic efficacy of Nitroxoline can be increased when used in combination with Manidipine.Approved
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Manidipine.Approved
NystatinThe therapeutic efficacy of Nystatin can be increased when used in combination with Manidipine.Approved, Vet Approved
ObinutuzumabManidipine may increase the hypotensive activities of Obinutuzumab.Approved, Investigational
OctamoxinOctamoxin may increase the hypotensive activities of Manidipine.Withdrawn
OlanzapineThe metabolism of Olanzapine can be decreased when combined with Manidipine.Approved, Investigational
OlmesartanOlmesartan may increase the hypotensive activities of Manidipine.Approved, Investigational
OlodaterolThe metabolism of Olodaterol can be decreased when combined with Manidipine.Approved
OmapatrilatOmapatrilat may increase the hypotensive activities of Manidipine.Investigational
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Manidipine.Approved, Investigational, Vet Approved
OmoconazoleThe therapeutic efficacy of Omoconazole can be increased when used in combination with Manidipine.Experimental
OndansetronThe metabolism of Ondansetron can be decreased when combined with Manidipine.Approved
OpiumThe metabolism of Opium can be decreased when combined with Manidipine.Approved, Illicit
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Manidipine.Approved, Investigational
OxaprozinThe metabolism of Oxaprozin can be decreased when combined with Manidipine.Approved
OxiconazoleThe therapeutic efficacy of Oxiconazole can be increased when used in combination with Manidipine.Approved
OxprenololOxprenolol may increase the hypotensive activities of Manidipine.Approved
OxycodoneThe metabolism of Oxycodone can be decreased when combined with Manidipine.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Manidipine.Approved, Investigational, Vet Approved
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Manidipine.Approved, Vet Approved
PafuramidineThe therapeutic efficacy of Pafuramidine can be increased when used in combination with Manidipine.Investigational
PaliperidoneThe risk or severity of hypotension can be increased when Paliperidone is combined with Manidipine.Approved
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Manidipine.Approved, Investigational
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Manidipine.Approved
ParecoxibThe metabolism of Parecoxib can be decreased when combined with Manidipine.Approved
PargylinePargyline may increase the hypotensive activities of Manidipine.Approved
ParoxetineThe metabolism of Paroxetine can be decreased when combined with Manidipine.Approved, Investigational
PazopanibThe metabolism of Pazopanib can be decreased when combined with Manidipine.Approved
PenbutololPenbutolol may increase the hypotensive activities of Manidipine.Approved, Investigational
PentamidineThe metabolism of Pentamidine can be decreased when combined with Manidipine.Approved, Investigational
PentobarbitalThe metabolism of Manidipine can be increased when combined with Pentobarbital.Approved, Investigational, Vet Approved
PentoliniumPentolinium may increase the hypotensive activities of Manidipine.Approved
PentoxifyllinePentoxifylline may increase the hypotensive activities of Manidipine.Approved, Investigational
PergolideThe risk or severity of adverse effects can be increased when Pergolide is combined with Manidipine.Approved, Investigational, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Manidipine.Approved, Investigational
PerindoprilPerindopril may increase the hypotensive activities of Manidipine.Approved
PerospironeThe metabolism of Perospirone can be decreased when combined with Manidipine.Approved
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Manidipine.Approved
PethidineThe metabolism of Pethidine can be decreased when combined with Manidipine.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Manidipine.Withdrawn
PhenelzinePhenelzine may increase the hypotensive activities of Manidipine.Approved
PhenforminThe metabolism of Phenformin can be decreased when combined with Manidipine.Approved, Investigational, Withdrawn
PheniprazinePheniprazine may increase the hypotensive activities of Manidipine.Withdrawn
PhenobarbitalThe metabolism of Manidipine can be increased when combined with Phenobarbital.Approved, Investigational
PhenoxybenzaminePhenoxybenzamine may increase the hypotensive activities of Manidipine.Approved
PhenoxypropazinePhenoxypropazine may increase the hypotensive activities of Manidipine.Withdrawn
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Manidipine.Approved, Investigational
PhentolaminePhentolamine may increase the hypotensive activities of Manidipine.Approved
PhenylbutazoneThe metabolism of Phenylbutazone can be decreased when combined with Manidipine.Approved, Vet Approved
PhenytoinThe metabolism of Phenytoin can be decreased when combined with Manidipine.Approved, Vet Approved
PinacidilPinacidil may increase the hypotensive activities of Manidipine.Approved
PindololPindolol may increase the hypotensive activities of Manidipine.Approved, Investigational
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Manidipine.Approved, Investigational
PiperaquineThe metabolism of Piperaquine can be decreased when combined with Manidipine.Approved, Investigational
PiperazineThe metabolism of Piperazine can be decreased when combined with Manidipine.Approved, Vet Approved
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Manidipine.Approved, Investigational
PirlindolePirlindole may increase the hypotensive activities of Manidipine.Approved
PiroxicamThe metabolism of Piroxicam can be decreased when combined with Manidipine.Approved, Investigational
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Manidipine.Approved
PitolisantThe serum concentration of Pitolisant can be increased when it is combined with Manidipine.Approved, Investigational
PivhydrazinePivhydrazine may increase the hypotensive activities of Manidipine.Withdrawn
PizotifenThe risk or severity of hypotension can be increased when Pizotifen is combined with Manidipine.Approved
Platelet Activating FactorPlatelet Activating Factor may increase the hypotensive activities of Manidipine.Experimental
PolythiazidePolythiazide may increase the hypotensive activities of Manidipine.Approved
PonatinibThe metabolism of Ponatinib can be decreased when combined with Manidipine.Approved, Investigational
PosaconazoleThe therapeutic efficacy of Posaconazole can be increased when used in combination with Manidipine.Approved, Investigational, Vet Approved
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Manidipine.Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Manidipine.Approved
PrazosinPrazosin may increase the hypotensive activities of Manidipine.Approved
PrimidoneThe metabolism of Manidipine can be increased when combined with Primidone.Approved, Vet Approved
ProcainamideThe metabolism of Procainamide can be decreased when combined with Manidipine.Approved
ProcaineProcaine may increase the hypotensive activities of Manidipine.Approved, Investigational, Vet Approved
ProcarbazineProcarbazine may increase the hypotensive activities of Manidipine.Approved, Investigational
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Manidipine.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Manidipine.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Manidipine.Approved
PromazineThe metabolism of Promazine can be decreased when combined with Manidipine.Approved, Vet Approved
PromethazineThe metabolism of Promethazine can be decreased when combined with Manidipine.Approved, Investigational
PropafenoneThe serum concentration of Manidipine can be increased when it is combined with Propafenone.Approved
PropericiazineThe risk or severity of hypotension can be increased when Propericiazine is combined with Manidipine.Approved, Investigational
PropiomazineThe risk or severity of hypotension can be increased when Propiomazine is combined with Manidipine.Approved
PropiverineThe risk or severity of hypotension can be increased when Propiverine is combined with Manidipine.Approved, Investigational
PropofolThe metabolism of Propofol can be decreased when combined with Manidipine.Approved, Investigational, Vet Approved
PropranololPropranolol may increase the hypotensive activities of Manidipine.Approved, Investigational
ProtriptylineThe metabolism of Protriptyline can be decreased when combined with Manidipine.Approved
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Manidipine.Approved
PyrrolnitrinThe therapeutic efficacy of Pyrrolnitrin can be increased when used in combination with Manidipine.Experimental
QuazepamThe metabolism of Quazepam can be decreased when combined with Manidipine.Approved, Illicit
QuetiapineThe metabolism of Quetiapine can be decreased when combined with Manidipine.Approved
QuinaprilQuinapril may increase the hypotensive activities of Manidipine.Approved, Investigational
QuinidineThe metabolism of Quinidine can be decreased when combined with Manidipine.Approved, Investigational
QuinineThe metabolism of Quinine can be decreased when combined with Manidipine.Approved
RacepinephrineThe risk or severity of hypotension can be increased when Racepinephrine is combined with Manidipine.Approved
RadicicolThe therapeutic efficacy of Radicicol can be increased when used in combination with Manidipine.Experimental
RamiprilRamipril may increase the hypotensive activities of Manidipine.Approved
RanitidineThe metabolism of Ranitidine can be decreased when combined with Manidipine.Approved
RasagilineRasagiline may increase the hypotensive activities of Manidipine.Approved
RemikirenRemikiren may increase the hypotensive activities of Manidipine.Approved
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Manidipine.Approved, Withdrawn
RepinotanThe metabolism of Repinotan can be decreased when combined with Manidipine.Investigational
RescinnamineManidipine may increase the hypotensive activities of Rescinnamine.Approved
ReserpineReserpine may increase the hypotensive activities of Manidipine.Approved, Investigational
RifabutinThe risk or severity of hypotension can be increased when Rifabutin is combined with Manidipine.Approved, Investigational
RifampicinThe risk or severity of hypotension can be increased when Rifampicin is combined with Manidipine.Approved
RifapentineThe risk or severity of hypotension can be increased when Rifapentine is combined with Manidipine.Approved, Investigational
RifaximinThe risk or severity of hypotension can be increased when Rifaximin is combined with Manidipine.Approved, Investigational
RilmenidineRilmenidine may increase the hypotensive activities of Manidipine.Approved, Investigational
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Manidipine.Approved
RiociguatManidipine may increase the hypotensive activities of Riociguat.Approved
RisperidoneThe metabolism of Risperidone can be decreased when combined with Manidipine.Approved, Investigational
RitonavirThe metabolism of Ritonavir can be decreased when combined with Manidipine.Approved, Investigational
RituximabManidipine may increase the hypotensive activities of Rituximab.Approved
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Manidipine.Approved, Investigational, Withdrawn
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Manidipine.Approved
RosiglitazoneThe metabolism of Rosiglitazone can be decreased when combined with Manidipine.Approved, Investigational
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Manidipine.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Manidipine.Approved
RucaparibThe metabolism of Rucaparib can be decreased when combined with Manidipine.Approved, Investigational
RupatadineThe metabolism of Rupatadine can be decreased when combined with Manidipine.Approved
SafrazineSafrazine may increase the hypotensive activities of Manidipine.Withdrawn
Salicylhydroxamic AcidThe therapeutic efficacy of Salicylhydroxamic Acid can be increased when used in combination with Manidipine.Experimental
Salicylic acidThe metabolism of Salicylic acid can be decreased when combined with Manidipine.Approved, Investigational, Vet Approved
SaprisartanSaprisartan may increase the hypotensive activities of Manidipine.Experimental
SaquinavirThe metabolism of Saquinavir can be decreased when combined with Manidipine.Approved, Investigational
SecobarbitalThe metabolism of Manidipine can be increased when combined with Secobarbital.Approved, Vet Approved
SelegilineSelegiline may increase the hypotensive activities of Manidipine.Approved, Investigational, Vet Approved
SelexipagManidipine may increase the hypotensive activities of Selexipag.Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Manidipine.Approved
SertaconazoleThe therapeutic efficacy of Sertaconazole can be increased when used in combination with Manidipine.Approved, Investigational
SertindoleThe metabolism of Sertindole can be decreased when combined with Manidipine.Approved, Investigational, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Manidipine.Approved
SildenafilSildenafil may increase the antihypertensive activities of Manidipine.Approved, Investigational
SilodosinThe risk or severity of hypotension can be increased when Silodosin is combined with Manidipine.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Manidipine.Approved
SinefunginThe therapeutic efficacy of Sinefungin can be increased when used in combination with Manidipine.Experimental
SirolimusThe therapeutic efficacy of Sirolimus can be increased when used in combination with Manidipine.Approved, Investigational
SitaxentanManidipine may increase the hypotensive activities of Sitaxentan.Approved, Investigational, Withdrawn
SparteineThe metabolism of Sparteine can be decreased when combined with Manidipine.Experimental
SpiraprilSpirapril may increase the hypotensive activities of Manidipine.Approved
SulconazoleThe therapeutic efficacy of Sulconazole can be increased when used in combination with Manidipine.Approved
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Manidipine.Approved, Investigational, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Manidipine.Approved
SulfamoxoleThe metabolism of Sulfamoxole can be decreased when combined with Manidipine.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Manidipine.Approved
SulfisoxazoleThe metabolism of Sulfisoxazole can be decreased when combined with Manidipine.Approved, Vet Approved
SuprofenThe metabolism of Suprofen can be decreased when combined with Manidipine.Approved, Withdrawn
TadalafilTadalafil may increase the antihypertensive activities of Manidipine.Approved, Investigational
TalinololManidipine may increase the hypotensive activities of Talinolol.Investigational
TamoxifenThe serum concentration of the active metabolites of Tamoxifen can be reduced when Tamoxifen is used in combination with Manidipine resulting in a loss in efficacy.Approved
TamsulosinThe risk or severity of hypotension can be increased when Tamsulosin is combined with Manidipine.Approved, Investigational
TapentadolThe metabolism of Tapentadol can be decreased when combined with Manidipine.Approved
TavaboroleThe therapeutic efficacy of Tavaborole can be increased when used in combination with Manidipine.Approved, Investigational
TegaserodThe metabolism of Tegaserod can be decreased when combined with Manidipine.Approved, Investigational, Withdrawn
TelmisartanTelmisartan may increase the hypotensive activities of Manidipine.Approved, Investigational
TemazepamThe metabolism of Temazepam can be decreased when combined with Manidipine.Approved, Investigational
TemocaprilTemocapril may increase the hypotensive activities of Manidipine.Experimental, Investigational
TenoxicamThe metabolism of Tenoxicam can be decreased when combined with Manidipine.Approved
TerazosinThe risk or severity of hypotension can be increased when Terazosin is combined with Manidipine.Approved
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Manidipine.Approved, Investigational, Vet Approved
TerconazoleThe therapeutic efficacy of Terconazole can be increased when used in combination with Manidipine.Approved
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Manidipine.Approved, Withdrawn
TergurideThe risk or severity of adverse effects can be increased when Terguride is combined with Manidipine.Experimental
TerlipressinTerlipressin may increase the hypotensive activities of Manidipine.Approved, Investigational
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Manidipine.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Manidipine.Approved, Investigational
Testosterone cypionateThe metabolism of Testosterone cypionate can be decreased when combined with Manidipine.Approved
Testosterone enanthateThe metabolism of Testosterone enanthate can be decreased when combined with Manidipine.Approved
Testosterone undecanoateThe metabolism of Testosterone undecanoate can be decreased when combined with Manidipine.Approved, Investigational
TetrabenazineThe metabolism of Tetrabenazine can be decreased when combined with Manidipine.Approved, Investigational
TetrahydropalmatineManidipine may increase the hypotensive activities of Tetrahydropalmatine.Investigational
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Manidipine.Approved, Investigational, Withdrawn
TheodrenalineManidipine may increase the hypotensive activities of Theodrenaline.Investigational
TheophyllineThe metabolism of Theophylline can be decreased when combined with Manidipine.Approved
ThiamylalThe metabolism of Manidipine can be increased when combined with Thiamylal.Approved, Vet Approved
ThiopentalThe metabolism of Manidipine can be increased when combined with Thiopental.Approved, Vet Approved
ThioproperazineThe risk or severity of hypotension can be increased when Thioproperazine is combined with Manidipine.Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Manidipine.Approved, Withdrawn
ThymolThe therapeutic efficacy of Thymol can be increased when used in combination with Manidipine.Approved
TiboloneTibolone may increase the hypotensive activities of Manidipine.Approved, Investigational
TiclopidineThe metabolism of Ticlopidine can be decreased when combined with Manidipine.Approved
TicrynafenTicrynafen may increase the hypotensive activities of Manidipine.Withdrawn
TimololTimolol may increase the hypotensive activities of Manidipine.Approved
TioconazoleThe therapeutic efficacy of Tioconazole can be increased when used in combination with Manidipine.Approved
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Manidipine.Approved
TipranavirThe metabolism of Tipranavir can be decreased when combined with Manidipine.Approved, Investigational
TizanidineThe serum concentration of Tizanidine can be increased when it is combined with Manidipine.Approved, Investigational
TolazolineTolazoline may increase the hypotensive activities of Manidipine.Approved, Vet Approved
TolbutamideThe metabolism of Tolbutamide can be decreased when combined with Manidipine.Approved, Investigational
TolciclateThe therapeutic efficacy of Tolciclate can be increased when used in combination with Manidipine.Experimental
TolnaftateThe therapeutic efficacy of Tolnaftate can be increased when used in combination with Manidipine.Approved, Investigational, Vet Approved
TolonidineManidipine may increase the hypotensive activities of Tolonidine.Experimental
ToloxatoneToloxatone may increase the hypotensive activities of Manidipine.Approved
TolterodineThe metabolism of Tolterodine can be decreased when combined with Manidipine.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Manidipine.Approved
TorasemideTorasemide may increase the hypotensive activities of Manidipine.Approved
TrabectedinThe metabolism of Trabectedin can be decreased when combined with Manidipine.Approved, Investigational
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Manidipine.Approved, Investigational
TrandolaprilTrandolapril may increase the hypotensive activities of Manidipine.Approved
TranylcypromineTranylcypromine may increase the hypotensive activities of Manidipine.Approved, Investigational
TravoprostTravoprost may increase the hypotensive activities of Manidipine.Approved
TrazodoneThe metabolism of Trazodone can be decreased when combined with Manidipine.Approved, Investigational
TreprostinilTreprostinil may increase the hypotensive activities of Manidipine.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Manidipine.Approved, Investigational, Nutraceutical
TrichlormethiazideTrichlormethiazide may increase the hypotensive activities of Manidipine.Approved, Vet Approved
TrifluoperazineThe risk or severity of hypotension can be increased when Trifluoperazine is combined with Manidipine.Approved, Investigational
TrimazosinTrimazosin may increase the hypotensive activities of Manidipine.Experimental
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Manidipine.Approved
TrimethaphanTrimethaphan may increase the hypotensive activities of Manidipine.Approved, Investigational
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Manidipine.Approved, Vet Approved
TrimetrexateThe therapeutic efficacy of Trimetrexate can be increased when used in combination with Manidipine.Approved, Investigational
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Manidipine.Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Manidipine.Investigational, Withdrawn
UdenafilUdenafil may increase the antihypertensive activities of Manidipine.Approved, Investigational
UmeclidiniumThe metabolism of Umeclidinium can be decreased when combined with Manidipine.Approved
UnoprostoneUnoprostone may increase the hypotensive activities of Manidipine.Approved, Investigational
UrapidilUrapidil may increase the hypotensive activities of Manidipine.Investigational
ValbenazineThe metabolism of Valbenazine can be decreased when combined with Manidipine.Approved, Investigational
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Manidipine.Approved, Investigational, Withdrawn
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Manidipine.Approved, Investigational
ValsartanValsartan may increase the hypotensive activities of Manidipine.Approved, Investigational
VardenafilVardenafil may increase the antihypertensive activities of Manidipine.Approved
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Manidipine.Approved
VerapamilThe metabolism of Verapamil can be decreased when combined with Manidipine.Approved
VernakalantThe metabolism of Vernakalant can be decreased when combined with Manidipine.Approved, Investigational
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Manidipine.Investigational
VilazodoneThe metabolism of Vilazodone can be decreased when combined with Manidipine.Approved
VinblastineThe metabolism of Vinblastine can be decreased when combined with Manidipine.Approved
VincamineManidipine may increase the hypotensive activities of Vincamine.Experimental
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Manidipine.Approved, Investigational
VinpocetineManidipine may increase the hypotensive activities of Vinpocetine.Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Manidipine.Approved, Investigational
VoriconazoleThe metabolism of Voriconazole can be decreased when combined with Manidipine.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Manidipine.Approved, Investigational
WarfarinThe metabolism of Warfarin can be decreased when combined with Manidipine.Approved
WortmanninThe therapeutic efficacy of Wortmannin can be increased when used in combination with Manidipine.Experimental
XimelagatranThe metabolism of Ximelagatran can be decreased when combined with Manidipine.Approved, Investigational, Withdrawn
XipamideManidipine may increase the hypotensive activities of Xipamide.Experimental
XylometazolineXylometazoline may increase the hypotensive activities of Manidipine.Approved, Investigational
YohimbineYohimbine may decrease the antihypertensive activities of Manidipine.Approved, Investigational, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Manidipine.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Manidipine.Approved, Investigational
ZaltoprofenThe metabolism of Zaltoprofen can be decreased when combined with Manidipine.Approved, Investigational
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Manidipine.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Manidipine.Approved, Investigational, Withdrawn
ZiprasidoneThe risk or severity of hypotension can be increased when Ziprasidone is combined with Manidipine.Approved
ZofenoprilManidipine may increase the hypotensive activities of Zofenopril.Experimental
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Manidipine.Approved
ZopicloneThe metabolism of Zopiclone can be decreased when combined with Manidipine.Approved
ZuclopenthixolThe metabolism of Zuclopenthixol can be decreased when combined with Manidipine.Approved, Investigational
Food Interactions
Not Available

References

General References
  1. Cheer SM, McClellan K: Manidipine: a review of its use in hypertension. Drugs. 2001;61(12):1777-99. [PubMed:11693466]
  2. McKeage K, Scott LJ: Manidipine: a review of its use in the management of hypertension. Drugs. 2004;64(17):1923-40. [PubMed:15329044]
External Links
PubChem Compound
4008
PubChem Substance
347827830
ChemSpider
3868
ChEBI
135849
ChEMBL
CHEMBL1085699
Wikipedia
Manidipine
ATC Codes
C08CA11 — ManidipineC09BB12 — Delapril and manidipine

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedTreatmentHigh Blood Pressure (Hypertension)1
4RecruitingTreatmentCardiovascular Disease (CVD) / Chronic Kidney Disease (CKD) / Hypertension,Essential / Strokes1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
water solubility<1mg/mLMSDS
Predicted Properties
PropertyValueSource
Water Solubility0.000995 mg/mLALOGPS
logP5.11ALOGPS
logP5.19ChemAxon
logS-5.8ALOGPS
pKa (Strongest Acidic)19.47ChemAxon
pKa (Strongest Basic)7.89ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area116.93 Å2ChemAxon
Rotatable Bond Count12ChemAxon
Refractivity175.13 m3·mol-1ChemAxon
Polarizability65.72 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Diphenylmethanes
Direct Parent
Diphenylmethanes
Alternative Parents
Dihydropyridinecarboxylic acids and derivatives / Nitrobenzenes / Nitroaromatic compounds / Aralkylamines / N-alkylpiperazines / Dicarboxylic acids and derivatives / Vinylogous amides / Enoate esters / Methyl esters / Amino acids and derivatives
show 11 more
Substituents
Diphenylmethane / Dihydropyridinecarboxylic acid derivative / Nitrobenzene / Nitroaromatic compound / Dihydropyridine / Aralkylamine / N-alkylpiperazine / 1,4-diazinane / Dicarboxylic acid or derivatives / Hydropyridine
show 32 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
Not Available

Targets

Kind
Protein group
Organism
Human
Pharmacological action
Yes
Actions
Blocker
General Function
Voltage-gated calcium channel activity
Specific Function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hor...

Components:
References
  1. McKeage K, Scott LJ: Manidipine: a review of its use in the management of hypertension. Drugs. 2004;64(17):1923-40. [PubMed:15329044]
Kind
Protein group
Organism
Homo sapiens
Pharmacological action
Yes
Actions
Blocker
General Function
Scaffold protein binding
Specific Function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hor...

Components:
References
  1. McKeage K, Scott LJ: Manidipine: a review of its use in the management of hypertension. Drugs. 2004;64(17):1923-40. [PubMed:15329044]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
Curator comments
Unknown if inhibition is clinically relevant.
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C9
Uniprot ID
P11712
Uniprot Name
Cytochrome P450 2C9
Molecular Weight
55627.365 Da
References
  1. McKeage K, Scott LJ: Manidipine: a review of its use in the management of hypertension. Drugs. 2004;64(17):1923-40. [PubMed:15329044]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
Curator comments
Unknown if inhibition is clinically relevant.
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
Gene Name
CYP2D6
Uniprot ID
P10635
Uniprot Name
Cytochrome P450 2D6
Molecular Weight
55768.94 Da
References
  1. McKeage K, Scott LJ: Manidipine: a review of its use in the management of hypertension. Drugs. 2004;64(17):1923-40. [PubMed:15329044]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Vitamin d 24-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A1
Uniprot ID
P04798
Uniprot Name
Cytochrome P450 1A1
Molecular Weight
58164.815 Da
References
  1. McKeage K, Scott LJ: Manidipine: a review of its use in the management of hypertension. Drugs. 2004;64(17):1923-40. [PubMed:15329044]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A2
Uniprot ID
P05177
Uniprot Name
Cytochrome P450 1A2
Molecular Weight
58293.76 Da
References
  1. McKeage K, Scott LJ: Manidipine: a review of its use in the management of hypertension. Drugs. 2004;64(17):1923-40. [PubMed:15329044]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2B6
Uniprot ID
P20813
Uniprot Name
Cytochrome P450 2B6
Molecular Weight
56277.81 Da
References
  1. McKeage K, Scott LJ: Manidipine: a review of its use in the management of hypertension. Drugs. 2004;64(17):1923-40. [PubMed:15329044]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and im...
Gene Name
CYP2C19
Uniprot ID
P33261
Uniprot Name
Cytochrome P450 2C19
Molecular Weight
55930.545 Da
References
  1. McKeage K, Scott LJ: Manidipine: a review of its use in the management of hypertension. Drugs. 2004;64(17):1923-40. [PubMed:15329044]
  2. Katoh M, Nakajima M, Shimada N, Yamazaki H, Yokoi T: Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions. Eur J Clin Pharmacol. 2000 Feb-Mar;55(11-12):843-52. [PubMed:10805063]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. McKeage K, Scott LJ: Manidipine: a review of its use in the management of hypertension. Drugs. 2004;64(17):1923-40. [PubMed:15329044]

Drug created on October 23, 2015 10:51 / Updated on July 02, 2018 19:13