Identification

Name
Manidipine
Accession Number
DB09238
Type
Small Molecule
Groups
Approved, Investigational
Description

Manidipine (INN) is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive. It is selective for vasculature and does not produce effects on the heart at clinically relevant dosages.

Structure
Thumb
Synonyms
Not Available
International/Other Brands
Caslot / Madipine / Manyper
Categories
UNII
6O4754US88
CAS number
89226-50-6
Weight
Average: 610.711
Monoisotopic: 610.27913496
Chemical Formula
C35H38N4O6
InChI Key
ANEBWFXPVPTEET-UHFFFAOYSA-N
InChI
InChI=1S/C35H38N4O6/c1-24-30(34(40)44-3)32(28-15-10-16-29(23-28)39(42)43)31(25(2)36-24)35(41)45-22-21-37-17-19-38(20-18-37)33(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-16,23,32-33,36H,17-22H2,1-3H3
IUPAC Name
3-{2-[4-(diphenylmethyl)piperazin-1-yl]ethyl} 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
SMILES
COC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)N(=O)=O)C(=O)OCCN1CCN(CC1)C(C1=CC=CC=C1)C1=CC=CC=C1

Pharmacology

Indication

For the treatment of hypertension.

Structured Indications
Not Available
Pharmacodynamics

Manidipine produces vasodilation resulting in lower blood pressure [1].

Mechanism of action

Contraction of vascular smooth muscle is stimulated by Gq coupled receptors which produce calcium release from the sarcoplasmic reticulum. This is followed by opening of voltage dependent calcium channels and an influx of calcium into the cell ultimately producing contraction. Manidipine binds to and dissociates slowly from L- and T-type voltage dependent calcium channels on smooth muscle cells, blocking the entrance of extracellular calcium into the cell and preventing this contraction [1, 2]. This produces vasodilation which decreases blood pressure. Manidipine produces renal vasodilation and an increase in natriuresis. This likely contributes to the antihypertensive effect by reducing blood volume. Manidipine is selective for the vasculature and does not produce significant effects on the heart or central nervous system at clinically relevant dosages.

TargetActionsOrganism
AVoltage dependent L type calcium channel
blocker
Human
AVoltage-dependent T-type calcium channel
blocker
Homo sapiens
Absorption

The median Tmax is 1.5 h [1]. Administration with food produces an 1.3-1.6-fold increase in Cmax but no change in Tmax. Manidipine does not accumulate significantly with multiple doses.

Volume of distribution
Not Available
Protein binding

Manidipine is 99% bound to human plasma proteins [1].

Metabolism

Manidipine is extensively metabolized by CYP enzymes to pyridine derivatives and diphenylmethane derivatives which make up 4-7% and 22-24% of the dose excreted in the urine [1].

Route of elimination

Manidipine is eliminated through extensive metabolism. 63% is eliminated in the feces and 31% in the urine as metabolites [1].

Half life

The half life of elimination has been observed to be dose dependent [1]. Doses of 5, 10, and 20 mg produced half lives of 3.94, 5.02, and 7.95 h respectively.

Clearance
Not Available
Toxicity

The most common adverse events reported in clinical trials were ankle oedema (6%), headache (3.8%), palpitation (2.7%), flushing (2.2%), dizziness (1.6%), rash (0.5%) and fatigue (0.5%) [1].

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
2-HYDROXY-1,4-NAPHTHOQUINONEThe risk or severity of adverse effects can be increased when 2-HYDROXY-1,4-NAPHTHOQUINONE is combined with Manidipine.Experimental
2-mercaptobenzothiazoleThe risk or severity of adverse effects can be increased when 2-mercaptobenzothiazole is combined with Manidipine.Vet Approved
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Manidipine.Experimental, Illicit
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline may increase the hypotensive activities of Manidipine.Experimental
AcebutololAcebutolol may increase the hypotensive activities of Manidipine.Approved
AceclofenacThe metabolism of Aceclofenac can be decreased when combined with Manidipine.Approved, Investigational
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Manidipine.Approved
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Manidipine.Approved
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Manidipine.Approved
Acetylsalicylic acidThe metabolism of Acetylsalicylic acid can be decreased when combined with Manidipine.Approved, Vet Approved
AjmalineThe metabolism of Ajmaline can be decreased when combined with Manidipine.Approved, Investigational
AlfuzosinAlfuzosin may increase the hypotensive activities of Manidipine.Approved, Investigational
AliskirenAliskiren may increase the hypotensive activities of Manidipine.Approved, Investigational
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Manidipine.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Manidipine.Approved
AlosetronThe metabolism of Alosetron can be decreased when combined with Manidipine.Approved, Withdrawn
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Manidipine.Approved, Illicit, Investigational
AlprenololAlprenolol may increase the hypotensive activities of Manidipine.Approved, Withdrawn
AmbrisentanManidipine may increase the hypotensive activities of Ambrisentan.Approved, Investigational
AmifostineManidipine may increase the hypotensive activities of Amifostine.Approved, Investigational
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Manidipine.Approved, Withdrawn
AmiodaroneThe metabolism of Amiodarone can be decreased when combined with Manidipine.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Manidipine.Approved
AmlodipineAmlodipine may increase the hypotensive activities of Manidipine.Approved
AmobarbitalThe metabolism of Manidipine can be increased when combined with Amobarbital.Approved, Illicit
AmorolfineThe risk or severity of adverse effects can be increased when Amorolfine is combined with Manidipine.Approved, Investigational
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Manidipine.Approved
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Manidipine.Approved, Illicit
Amphotericin BThe risk or severity of adverse effects can be increased when Amphotericin B is combined with Manidipine.Approved, Investigational
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Manidipine.Approved
AmsacrineThe metabolism of Amsacrine can be decreased when combined with Manidipine.Approved
AnidulafunginThe risk or severity of adverse effects can be increased when Anidulafungin is combined with Manidipine.Approved, Investigational
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Manidipine.Approved
ApixabanThe metabolism of Apixaban can be decreased when combined with Manidipine.Approved
AprindineThe metabolism of Aprindine can be decreased when combined with Manidipine.Approved
Arachidonic AcidThe metabolism of Arachidonic Acid can be decreased when combined with Manidipine.Experimental
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Manidipine.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Manidipine.Approved, Investigational
ArtemetherThe risk or severity of adverse effects can be increased when Artemether is combined with Manidipine.Approved
AstemizoleThe metabolism of Astemizole can be decreased when combined with Manidipine.Approved, Withdrawn
AtazanavirThe metabolism of Atazanavir can be decreased when combined with Manidipine.Approved, Investigational
AtenololAtenolol may increase the hypotensive activities of Manidipine.Approved
AtomoxetineThe metabolism of Atomoxetine can be decreased when combined with Manidipine.Approved
AtorvastatinThe risk or severity of adverse effects can be increased when Manidipine is combined with Atorvastatin.Approved
AtosibanThe risk or severity of adverse effects can be increased when Manidipine is combined with Atosiban.Approved, Investigational
Atracurium besylateManidipine may increase the neuromuscular blocking activities of Atracurium besylate.Approved
AvanafilAvanafil may increase the antihypertensive activities of Manidipine.Approved
AzelastineThe metabolism of Azelastine can be decreased when combined with Manidipine.Approved
Bafilomycin A1The risk or severity of adverse effects can be increased when Bafilomycin A1 is combined with Manidipine.Experimental
BarbexacloneThe metabolism of Manidipine can be increased when combined with Barbexaclone.Experimental
BarbitalThe metabolism of Manidipine can be increased when combined with Barbital.Illicit
BenazeprilBenazepril may increase the hypotensive activities of Manidipine.Approved, Investigational
BendroflumethiazideBendroflumethiazide may increase the hypotensive activities of Manidipine.Approved
BenmoxinBenmoxin may increase the hypotensive activities of Manidipine.Withdrawn
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Manidipine.Approved
Benzoic AcidThe risk or severity of adverse effects can be increased when Benzoic Acid is combined with Manidipine.Approved
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Manidipine.Approved
BepridilBepridil may increase the hypotensive activities of Manidipine.Approved, Withdrawn
BetaxololBetaxolol may increase the hypotensive activities of Manidipine.Approved
BethanidineBethanidine may increase the hypotensive activities of Manidipine.Approved
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Manidipine.Approved, Investigational
BietaserpineBietaserpine may increase the hypotensive activities of Manidipine.Experimental
BifonazoleThe risk or severity of adverse effects can be increased when Bifonazole is combined with Manidipine.Approved, Investigational
BimatoprostBimatoprost may increase the hypotensive activities of Manidipine.Approved, Investigational
BisoprololBisoprolol may increase the hypotensive activities of Manidipine.Approved
BortezomibThe metabolism of Bortezomib can be decreased when combined with Manidipine.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Manidipine.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Manidipine.Approved
BQ-123Manidipine may increase the hypotensive activities of BQ-123.Investigational
Brefeldin AThe risk or severity of adverse effects can be increased when Brefeldin A is combined with Manidipine.Experimental
BretyliumBretylium may increase the hypotensive activities of Manidipine.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Manidipine.Approved
BrimonidineBrimonidine may increase the antihypertensive activities of Manidipine.Approved
BrivaracetamThe metabolism of Brivaracetam can be decreased when combined with Manidipine.Approved, Investigational
BrofaromineBrofaromine may increase the hypotensive activities of Manidipine.Experimental
BromocriptineThe risk or severity of adverse effects can be increased when Bromocriptine is combined with Manidipine.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Manidipine.Approved
BucindololBucindolol may increase the hypotensive activities of Manidipine.Investigational
BufuralolThe metabolism of Bufuralol can be decreased when combined with Manidipine.Experimental, Investigational
BunazosinBunazosin may increase the hypotensive activities of Manidipine.Investigational
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Manidipine.Approved, Investigational
BupranololBupranolol may increase the hypotensive activities of Manidipine.Approved
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Manidipine.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be decreased when combined with Manidipine.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Manidipine.Approved, Investigational
ButenafineThe risk or severity of adverse effects can be increased when Butenafine is combined with Manidipine.Approved
ButoconazoleThe risk or severity of adverse effects can be increased when Butoconazole is combined with Manidipine.Approved
CabergolineThe risk or severity of adverse effects can be increased when Cabergoline is combined with Manidipine.Approved
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Manidipine.Approved
CadralazineCadralazine may increase the hypotensive activities of Manidipine.Experimental
CafedrineManidipine may increase the hypotensive activities of Cafedrine.Investigational
CaffeineThe metabolism of Caffeine can be decreased when combined with Manidipine.Approved
Calcium AcetateThe therapeutic efficacy of Manidipine can be decreased when used in combination with Calcium Acetate.Approved
Calcium CarbonateThe therapeutic efficacy of Manidipine can be decreased when used in combination with Calcium Carbonate.Approved
Calcium ChlorideThe therapeutic efficacy of Manidipine can be decreased when used in combination with Calcium Chloride.Approved
Calcium CitrateThe therapeutic efficacy of Manidipine can be decreased when used in combination with Calcium Citrate.Approved
Calcium glubionateThe therapeutic efficacy of Manidipine can be decreased when used in combination with Calcium glubionate.Approved
Calcium GluceptateThe therapeutic efficacy of Manidipine can be decreased when used in combination with Calcium Gluceptate.Approved
Calcium gluconateThe therapeutic efficacy of Manidipine can be decreased when used in combination with Calcium gluconate.Approved, Vet Approved
Calcium lactateThe therapeutic efficacy of Manidipine can be decreased when used in combination with Calcium lactate.Approved, Experimental, Investigational, Vet Approved
Calcium lactate gluconateThe therapeutic efficacy of Manidipine can be decreased when used in combination with Calcium lactate gluconate.Experimental
Calcium laevulateThe therapeutic efficacy of Manidipine can be decreased when used in combination with Calcium laevulate.Experimental
Calcium pangamateThe therapeutic efficacy of Manidipine can be decreased when used in combination with Calcium pangamate.Experimental
Calcium PhosphateThe therapeutic efficacy of Manidipine can be decreased when used in combination with Calcium Phosphate.Approved
CandesartanThe metabolism of Candesartan can be decreased when combined with Manidipine.Experimental
Candesartan cilexetilCandesartan cilexetil may increase the hypotensive activities of Manidipine.Approved
CandicidinThe risk or severity of adverse effects can be increased when Candicidin is combined with Manidipine.Withdrawn
CandoxatrilCandoxatril may increase the hypotensive activities of Manidipine.Experimental
Capric acidThe risk or severity of adverse effects can be increased when Capric acid is combined with Manidipine.Experimental
CaptoprilCaptopril may increase the hypotensive activities of Manidipine.Approved
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Manidipine.Approved
CarbomycinThe metabolism of Manidipine can be decreased when combined with Carbomycin.Vet Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Manidipine.Approved
CaroxazoneCaroxazone may increase the hypotensive activities of Manidipine.Withdrawn
CarteololCarteolol may increase the hypotensive activities of Manidipine.Approved
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Manidipine.Approved, Investigational
CaseinThe therapeutic efficacy of Manidipine can be decreased when used in combination with Casein.Approved
CaspofunginThe risk or severity of adverse effects can be increased when Caspofungin is combined with Manidipine.Approved
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Manidipine.Approved, Investigational
CeliprololCeliprolol may increase the hypotensive activities of Manidipine.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Manidipine.Approved, Vet Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Manidipine.Withdrawn
CeruleninThe risk or severity of adverse effects can be increased when Cerulenin is combined with Manidipine.Approved
CevimelineThe metabolism of Cevimeline can be decreased when combined with Manidipine.Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Manidipine.Approved, Illicit
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Manidipine.Approved, Vet Approved
ChlorothiazideChlorothiazide may increase the hypotensive activities of Manidipine.Approved, Vet Approved
ChloroxineThe risk or severity of adverse effects can be increased when Chloroxine is combined with Manidipine.Approved
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Manidipine.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Manidipine.Approved, Vet Approved
ChlorpropamideThe metabolism of Chlorpropamide can be decreased when combined with Manidipine.Approved
ChlorthalidoneChlorthalidone may increase the hypotensive activities of Manidipine.Approved
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Manidipine.Approved
CicletanineManidipine may increase the hypotensive activities of Cicletanine.Investigational
CiclopiroxThe risk or severity of adverse effects can be increased when Ciclopirox is combined with Manidipine.Approved, Investigational
CilazaprilCilazapril may increase the hypotensive activities of Manidipine.Approved
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Manidipine.Approved
CimetidineThe serum concentration of Manidipine can be increased when it is combined with Cimetidine.Approved
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Manidipine.Approved, Investigational
CisaprideThe metabolism of Cisapride can be decreased when combined with Manidipine.Approved, Investigational, Withdrawn
CitalopramThe metabolism of Citalopram can be decreased when combined with Manidipine.Approved
ClarithromycinThe metabolism of Manidipine can be decreased when combined with Clarithromycin.Approved
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Manidipine.Approved
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Manidipine.Approved, Vet Approved
ClonidineClonidine may increase the hypotensive activities of Manidipine.Approved
ClopidogrelThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Manidipine.Approved, Nutraceutical
CloranololManidipine may increase the hypotensive activities of Cloranolol.Experimental
ClotrimazoleThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Manidipine.Approved, Vet Approved
ClozapineThe metabolism of Clozapine can be decreased when combined with Manidipine.Approved
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Manidipine.Approved, Illicit
CordycepinThe risk or severity of adverse effects can be increased when Cordycepin is combined with Manidipine.Investigational
CryptenamineCryptenamine may increase the hypotensive activities of Manidipine.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Manidipine.Approved
CyclopenthiazideManidipine may increase the hypotensive activities of Cyclopenthiazide.Experimental
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Manidipine.Approved, Investigational
CyclosporineThe risk or severity of adverse effects can be increased when Cyclosporine is combined with Manidipine.Approved, Investigational, Vet Approved
CyclothiazideCyclothiazide may increase the hypotensive activities of Manidipine.Approved
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Manidipine.Approved
DapoxetineDapoxetine may increase the orthostatic hypotensive activities of Manidipine.Investigational
DapsoneThe metabolism of Dapsone can be decreased when combined with Manidipine.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Manidipine.Approved, Investigational
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Manidipine.Approved
DebrisoquinDebrisoquin may increase the hypotensive activities of Manidipine.Approved, Investigational
DelaprilManidipine may increase the hypotensive activities of Delapril.Experimental
DelavirdineThe metabolism of Delavirdine can be decreased when combined with Manidipine.Approved
DeserpidineManidipine may increase the hypotensive activities of Deserpidine.Approved
DesipramineThe metabolism of Desipramine can be decreased when combined with Manidipine.Approved
DeutetrabenazineThe metabolism of Deutetrabenazine can be decreased when combined with Manidipine.Approved, Investigational
Dexchlorpheniramine maleateThe metabolism of Dexchlorpheniramine maleate can be decreased when combined with Manidipine.Approved
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Manidipine.Approved, Illicit, Investigational, Withdrawn
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Manidipine.Approved
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Manidipine.Approved, Illicit
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Manidipine.Approved
DiazepamThe metabolism of Diazepam can be decreased when combined with Manidipine.Approved, Illicit, Vet Approved
DiazoxideDiazoxide may increase the hypotensive activities of Manidipine.Approved
DichloropheneThe risk or severity of adverse effects can be increased when Dichlorophene is combined with Manidipine.Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Manidipine.Approved, Vet Approved
DicoumarolThe metabolism of Dicoumarol can be decreased when combined with Manidipine.Approved
diethylnorsperminediethylnorspermine may increase the hypotensive activities of Manidipine.Investigational
DihydralazineDihydralazine may increase the hypotensive activities of Manidipine.Investigational
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Manidipine.Approved, Illicit
DihydroergocornineThe risk or severity of adverse effects can be increased when Dihydroergocornine is combined with Manidipine.Approved
DihydroergocristineThe risk or severity of adverse effects can be increased when Dihydroergocristine is combined with Manidipine.Experimental
DihydroergocryptineThe risk or severity of adverse effects can be increased when Dihydroergocryptine is combined with Manidipine.Experimental
DihydroergotamineThe risk or severity of adverse effects can be increased when Dihydroergotamine is combined with Manidipine.Approved
DiltiazemDiltiazem may increase the hypotensive activities of Manidipine.Approved
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Manidipine.Approved
DoconexentThe metabolism of Doconexent can be decreased when combined with Manidipine.Approved, Investigational
DolasetronThe metabolism of Dolasetron can be decreased when combined with Manidipine.Approved
DomperidoneThe metabolism of Domperidone can be decreased when combined with Manidipine.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Manidipine.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Manidipine.Approved
DorzolamideDorzolamide may increase the hypotensive activities of Manidipine.Approved
DoxazosinDoxazosin may increase the hypotensive activities of Manidipine.Approved
DoxepinThe metabolism of Doxepin can be decreased when combined with Manidipine.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Manidipine.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Manidipine.Approved, Investigational
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Manidipine.Approved, Illicit
DronedaroneThe metabolism of Dronedarone can be decreased when combined with Manidipine.Approved
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Manidipine.Approved
EconazoleThe risk or severity of adverse effects can be increased when Econazole is combined with Manidipine.Approved
EfavirenzThe serum concentration of Manidipine can be decreased when it is combined with Efavirenz.Approved, Investigational
EfinaconazoleThe risk or severity of adverse effects can be increased when Efinaconazole is combined with Manidipine.Approved
EfonidipineEfonidipine may increase the hypotensive activities of Manidipine.Approved, Investigational
EletriptanThe metabolism of Eletriptan can be decreased when combined with Manidipine.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Manidipine.Approved
EnalaprilEnalapril may increase the hypotensive activities of Manidipine.Approved, Vet Approved
EnalaprilatManidipine may increase the hypotensive activities of Enalaprilat.Approved
EnasidenibThe metabolism of Enasidenib can be decreased when combined with Manidipine.Approved
EncainideThe metabolism of Encainide can be decreased when combined with Manidipine.Approved, Investigational, Withdrawn
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Manidipine.Investigational
EndralazineEndralazine may increase the hypotensive activities of Manidipine.Experimental
EpanololManidipine may increase the hypotensive activities of Epanolol.Experimental
EpinastineThe metabolism of Epinastine can be decreased when combined with Manidipine.Approved, Investigational
EpoprostenolEpoprostenol may increase the hypotensive activities of Manidipine.Approved
EprosartanEprosartan may increase the hypotensive activities of Manidipine.Approved
ErgonovineThe risk or severity of adverse effects can be increased when Ergonovine is combined with Manidipine.Approved
ErgotamineThe risk or severity of adverse effects can be increased when Ergotamine is combined with Manidipine.Approved
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Manidipine.Approved, Investigational
ErythromycinThe metabolism of Manidipine can be decreased when combined with Erythromycin.Approved, Vet Approved
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Manidipine.Approved, Investigational
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Manidipine.Investigational
EstradiolThe metabolism of Estradiol can be decreased when combined with Manidipine.Approved, Investigational, Vet Approved
EstroneThe metabolism of Estrone can be decreased when combined with Manidipine.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Manidipine.Approved
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Manidipine.Approved, Illicit
EtodolacThe metabolism of Etodolac can be decreased when combined with Manidipine.Approved, Investigational, Vet Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Manidipine.Approved, Investigational
EtravirineThe metabolism of Etravirine can be decreased when combined with Manidipine.Approved
FelodipineFelodipine may increase the hypotensive activities of Manidipine.Approved, Investigational
FenoldopamFenoldopam may increase the hypotensive activities of Manidipine.Approved
FenticonazoleThe risk or severity of adverse effects can be increased when Fenticonazole is combined with Manidipine.Experimental
Ferulic acidFerulic acid may increase the hypotensive activities of Manidipine.Experimental
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Manidipine.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Manidipine.Approved, Investigational
FlecainideThe metabolism of Flecainide can be decreased when combined with Manidipine.Approved, Withdrawn
FluconazoleThe serum concentration of Manidipine can be increased when it is combined with Fluconazole.Approved
FlucytosineThe risk or severity of adverse effects can be increased when Flucytosine is combined with Manidipine.Approved
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Manidipine.Approved
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Manidipine.Approved, Illicit
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Manidipine.Approved, Vet Approved
FluphenazineThe metabolism of Fluphenazine can be decreased when combined with Manidipine.Approved
FlurbiprofenThe metabolism of Flurbiprofen can be decreased when combined with Manidipine.Approved, Investigational
FlutrimazoleThe risk or severity of adverse effects can be increased when Flutrimazole is combined with Manidipine.Experimental
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Manidipine.Approved
FluvoxamineThe metabolism of Fluvoxamine can be decreased when combined with Manidipine.Approved, Investigational
FormoterolThe metabolism of Formoterol can be decreased when combined with Manidipine.Approved, Investigational
FosinoprilFosinopril may increase the hypotensive activities of Manidipine.Approved
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Manidipine.Approved
FurazolidoneFurazolidone may increase the hypotensive activities of Manidipine.Approved, Investigational, Vet Approved
GalantamineThe metabolism of Galantamine can be decreased when combined with Manidipine.Approved
GavestinelThe metabolism of Gavestinel can be decreased when combined with Manidipine.Investigational
GefitinibThe metabolism of Gefitinib can be decreased when combined with Manidipine.Approved, Investigational
GliclazideThe metabolism of Gliclazide can be decreased when combined with Manidipine.Approved
GlimepirideThe metabolism of Glimepiride can be decreased when combined with Manidipine.Approved
GlipizideThe metabolism of Glipizide can be decreased when combined with Manidipine.Approved
GlyburideThe metabolism of Glyburide can be decreased when combined with Manidipine.Approved
GlyphosateThe risk or severity of adverse effects can be increased when Glyphosate is combined with Manidipine.Experimental
GranisetronThe metabolism of Granisetron can be decreased when combined with Manidipine.Approved, Investigational
GriseofulvinThe risk or severity of adverse effects can be increased when Griseofulvin is combined with Manidipine.Approved, Vet Approved
GuanabenzGuanabenz may increase the hypotensive activities of Manidipine.Approved, Investigational
GuanadrelGuanadrel may increase the hypotensive activities of Manidipine.Approved
GuanazodineManidipine may increase the hypotensive activities of Guanazodine.Experimental
GuanethidineGuanethidine may increase the hypotensive activities of Manidipine.Approved
GuanfacineGuanfacine may increase the hypotensive activities of Manidipine.Approved, Investigational
GuanoclorManidipine may increase the hypotensive activities of Guanoclor.Experimental
GuanoxabenzManidipine may increase the hypotensive activities of Guanoxabenz.Experimental
GuanoxanManidipine may increase the hypotensive activities of Guanoxan.Experimental
HachimycinThe risk or severity of adverse effects can be increased when Hachimycin is combined with Manidipine.Experimental
HalofantrineThe metabolism of Halofantrine can be decreased when combined with Manidipine.Approved
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Manidipine.Approved
HaloproginThe risk or severity of adverse effects can be increased when Haloprogin is combined with Manidipine.Approved, Withdrawn
HalothaneThe metabolism of Halothane can be decreased when combined with Manidipine.Approved, Vet Approved
HarmalineHarmaline may increase the hypotensive activities of Manidipine.Experimental
HexamethoniumHexamethonium may increase the hypotensive activities of Manidipine.Experimental
HexetidineThe risk or severity of adverse effects can be increased when Hexetidine is combined with Manidipine.Approved, Investigational
HexobarbitalThe metabolism of Manidipine can be increased when combined with Hexobarbital.Approved
HistamineThe metabolism of Histamine can be decreased when combined with Manidipine.Approved, Investigational
HydracarbazineHydracarbazine may increase the hypotensive activities of Manidipine.Experimental
HydralazineHydralazine may increase the hypotensive activities of Manidipine.Approved
HydrochlorothiazideHydrochlorothiazide may increase the hypotensive activities of Manidipine.Approved, Vet Approved
HydrocodoneThe metabolism of Hydrocodone can be decreased when combined with Manidipine.Approved, Illicit
HydroflumethiazideHydroflumethiazide may increase the hypotensive activities of Manidipine.Approved, Investigational
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Manidipine.Approved, Illicit
IbrutinibThe metabolism of Ibrutinib can be decreased when combined with Manidipine.Approved
IbuprofenThe metabolism of Ibuprofen can be decreased when combined with Manidipine.Approved
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Manidipine.Approved
IfosfamideThe metabolism of Ifosfamide can be decreased when combined with Manidipine.Approved
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Manidipine.Approved
IloprostIloprost may increase the hypotensive activities of Manidipine.Approved, Investigational
ImatinibThe metabolism of Imatinib can be decreased when combined with Manidipine.Approved
ImidaprilManidipine may increase the hypotensive activities of Imidapril.Investigational
ImipramineThe metabolism of Imipramine can be decreased when combined with Manidipine.Approved
IndapamideIndapamide may increase the hypotensive activities of Manidipine.Approved
IndenololIndenolol may increase the hypotensive activities of Manidipine.Withdrawn
indisulamThe metabolism of indisulam can be decreased when combined with Manidipine.Investigational
IndomethacinThe metabolism of Indomethacin can be decreased when combined with Manidipine.Approved, Investigational
IndoraminIndoramin may increase the hypotensive activities of Manidipine.Withdrawn
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Manidipine.Approved
IproclozideIproclozide may increase the hypotensive activities of Manidipine.Withdrawn
IproniazidIproniazid may increase the hypotensive activities of Manidipine.Withdrawn
IrbesartanIrbesartan may increase the hypotensive activities of Manidipine.Approved, Investigational
IsocarboxazidIsocarboxazid may increase the hypotensive activities of Manidipine.Approved
IsoconazoleThe risk or severity of adverse effects can be increased when Isoconazole is combined with Manidipine.Approved
IsradipineIsradipine may increase the hypotensive activities of Manidipine.Approved
ItraconazoleThe risk or severity of adverse effects can be increased when Itraconazole is combined with Manidipine.Approved, Investigational
IxazomibThe metabolism of Ixazomib can be decreased when combined with Manidipine.Approved
JosamycinThe metabolism of Manidipine can be decreased when combined with Josamycin.Approved, Investigational
KetamineThe metabolism of Ketamine can be decreased when combined with Manidipine.Approved, Vet Approved
KetanserinKetanserin may increase the hypotensive activities of Manidipine.Investigational
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Manidipine.Approved, Investigational
KetoconazoleThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Manidipine.Approved, Investigational
KetoprofenThe metabolism of Ketoprofen can be decreased when combined with Manidipine.Approved, Vet Approved
KitasamycinThe metabolism of Manidipine can be decreased when combined with Kitasamycin.Experimental
LabetalolLabetalol may increase the hypotensive activities of Manidipine.Approved
LacidipineLacidipine may increase the hypotensive activities of Manidipine.Approved, Investigational
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Manidipine.Approved, Investigational
LatanoprostLatanoprost may increase the hypotensive activities of Manidipine.Approved, Investigational
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Manidipine.Approved, Investigational
LercanidipineLercanidipine may increase the hypotensive activities of Manidipine.Approved, Investigational
LesinuradThe metabolism of Lesinurad can be decreased when combined with Manidipine.Approved
LetermovirThe metabolism of Letermovir can be decreased when combined with Manidipine.Approved
LevodopaThe metabolism of Levodopa can be decreased when combined with Manidipine.Approved
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Manidipine.Approved
LicofeloneThe metabolism of Licofelone can be decreased when combined with Manidipine.Investigational
LidocaineThe metabolism of Lidocaine can be decreased when combined with Manidipine.Approved, Vet Approved
LinsidomineManidipine may increase the hypotensive activities of Linsidomine.Experimental
LisinoprilLisinopril may increase the hypotensive activities of Manidipine.Approved, Investigational
LisurideThe metabolism of Lisuride can be decreased when combined with Manidipine.Approved, Investigational
LofexidineLofexidine may increase the hypotensive activities of Manidipine.Approved, Investigational
LomustineThe metabolism of Lomustine can be decreased when combined with Manidipine.Approved
LoperamideThe metabolism of Loperamide can be decreased when combined with Manidipine.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Manidipine.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Manidipine.Approved
LornoxicamThe metabolism of Lornoxicam can be decreased when combined with Manidipine.Approved, Investigational
LosartanLosartan may increase the hypotensive activities of Manidipine.Approved
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Manidipine.Approved, Investigational
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Manidipine.Approved, Investigational
Lysergic Acid DiethylamideThe risk or severity of adverse effects can be increased when Lysergic Acid Diethylamide is combined with Manidipine.Illicit, Investigational, Withdrawn
MacitentanManidipine may increase the hypotensive activities of Macitentan.Approved
Magnesium HydroxideThe risk or severity of adverse effects can be increased when Manidipine is combined with Magnesium Hydroxide.Approved
Magnesium oxideThe risk or severity of adverse effects can be increased when Manidipine is combined with Magnesium oxide.Approved
Magnesium salicylateThe risk or severity of adverse effects can be increased when Manidipine is combined with Magnesium salicylate.Approved
Magnesium SulfateThe risk or severity of adverse effects can be increased when Manidipine is combined with Magnesium Sulfate.Approved, Vet Approved
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Manidipine.Approved
MebanazineMebanazine may increase the hypotensive activities of Manidipine.Withdrawn
MecamylamineMecamylamine may increase the hypotensive activities of Manidipine.Approved
Mefenamic acidThe metabolism of Mefenamic acid can be decreased when combined with Manidipine.Approved
MelatoninThe metabolism of Melatonin can be decreased when combined with Manidipine.Approved, Nutraceutical, Vet Approved
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Manidipine.Approved, Vet Approved
MepartricinThe risk or severity of adverse effects can be increased when Mepartricin is combined with Manidipine.Experimental
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Manidipine.Investigational, Withdrawn
MequitazineThe metabolism of Mequitazine can be decreased when combined with Manidipine.Approved
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Manidipine.Approved, Investigational
MestranolThe metabolism of Mestranol can be decreased when combined with Manidipine.Approved
MetergolineThe risk or severity of adverse effects can be increased when Metergoline is combined with Manidipine.Experimental
MethadoneThe metabolism of Methadone can be decreased when combined with Manidipine.Approved
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Manidipine.Approved, Illicit
MethohexitalThe metabolism of Manidipine can be increased when combined with Methohexital.Approved
MethoserpidineManidipine may increase the hypotensive activities of Methoserpidine.Experimental
MethotrimeprazineThe metabolism of Methotrimeprazine can be decreased when combined with Manidipine.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Manidipine.Approved, Investigational, Vet Approved
MethyldopaMethyldopa may increase the hypotensive activities of Manidipine.Approved
Methylene blueMethylene blue may increase the hypotensive activities of Manidipine.Approved, Investigational
MethylergometrineThe risk or severity of adverse effects can be increased when Methylergometrine is combined with Manidipine.Approved
MethylphenidateMethylphenidate may decrease the antihypertensive activities of Manidipine.Approved, Investigational
MethylphenobarbitalThe metabolism of Manidipine can be increased when combined with Methylphenobarbital.Approved
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Manidipine.Approved, Illicit, Withdrawn
MethysergideThe risk or severity of adverse effects can be increased when Methysergide is combined with Manidipine.Approved
MetipranololMetipranolol may increase the hypotensive activities of Manidipine.Approved
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Manidipine.Approved, Investigational
MetolazoneMetolazone may increase the hypotensive activities of Manidipine.Approved
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Manidipine.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Manidipine.Approved
MetyrosineManidipine may increase the hypotensive activities of Metyrosine.Approved
MevastatinThe risk or severity of adverse effects can be increased when Mevastatin is combined with Manidipine.Experimental
MexiletineThe metabolism of Mexiletine can be decreased when combined with Manidipine.Approved
MianserinThe metabolism of Mianserin can be decreased when combined with Manidipine.Approved, Investigational
MibefradilMibefradil may increase the hypotensive activities of Manidipine.Investigational, Withdrawn
MicafunginThe risk or severity of adverse effects can be increased when Micafungin is combined with Manidipine.Approved, Investigational
MiconazoleThe risk or severity of adverse effects can be increased when Miconazole is combined with Manidipine.Approved, Investigational, Vet Approved
MiltefosineThe risk or severity of adverse effects can be increased when Miltefosine is combined with Manidipine.Approved
MinaprineMinaprine may increase the hypotensive activities of Manidipine.Approved
MinoxidilMinoxidil may increase the hypotensive activities of Manidipine.Approved
MirabegronThe metabolism of Mirabegron can be decreased when combined with Manidipine.Approved
MirodenafilMirodenafil may increase the antihypertensive activities of Manidipine.Investigational
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Manidipine.Approved
MivacuriumManidipine may increase the neuromuscular blocking activities of Mivacurium.Approved
MoclobemideMoclobemide may increase the hypotensive activities of Manidipine.Approved
MoexiprilMoexipril may increase the hypotensive activities of Manidipine.Approved
MolsidomineMolsidomine may increase the hypotensive activities of Manidipine.Approved, Investigational
MonensinThe risk or severity of adverse effects can be increased when Monensin is combined with Manidipine.Vet Approved
MontelukastThe metabolism of Montelukast can be decreased when combined with Manidipine.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Manidipine.Approved, Investigational
MoxonidineMoxonidine may increase the hypotensive activities of Manidipine.Approved, Investigational
MuzolimineManidipine may increase the hypotensive activities of Muzolimine.Experimental
MyxothiazolThe risk or severity of adverse effects can be increased when Myxothiazol is combined with Manidipine.Experimental
NadololNadolol may increase the hypotensive activities of Manidipine.Approved
NafcillinThe metabolism of Manidipine can be increased when combined with Nafcillin.Approved
NaftifineThe risk or severity of adverse effects can be increased when Naftifine is combined with Manidipine.Approved
NaftopidilManidipine may increase the hypotensive activities of Naftopidil.Investigational
NaproxenThe metabolism of Naproxen can be decreased when combined with Manidipine.Approved, Vet Approved
NatamycinThe risk or severity of adverse effects can be increased when Natamycin is combined with Manidipine.Approved
NateglinideThe metabolism of Nateglinide can be decreased when combined with Manidipine.Approved, Investigational
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Manidipine.Approved, Investigational
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Manidipine.Approved, Withdrawn
NetupitantThe metabolism of Netupitant can be decreased when combined with Manidipine.Approved
NevirapineThe metabolism of Nevirapine can be decreased when combined with Manidipine.Approved
NialamideNialamide may increase the hypotensive activities of Manidipine.Withdrawn
NicardipineNicardipine may increase the hypotensive activities of Manidipine.Approved
NicergolineThe metabolism of Nicergoline can be decreased when combined with Manidipine.Approved, Investigational
NiclosamideThe metabolism of Niclosamide can be decreased when combined with Manidipine.Approved, Investigational, Vet Approved
NicorandilNicorandil may increase the hypotensive activities of Manidipine.Approved, Investigational
NicotineThe metabolism of Nicotine can be decreased when combined with Manidipine.Approved
NifedipineThe metabolism of Nifedipine can be decreased when combined with Manidipine.Approved
NifuratelThe risk or severity of adverse effects can be increased when Nifuratel is combined with Manidipine.Experimental
NiguldipineManidipine may increase the hypotensive activities of Niguldipine.Experimental
Nikkomycin ZThe risk or severity of adverse effects can be increased when Nikkomycin Z is combined with Manidipine.Investigational
NilvadipineNilvadipine may increase the hypotensive activities of Manidipine.Approved, Investigational
NimodipineNimodipine may increase the hypotensive activities of Manidipine.Approved
NisoldipineNisoldipine may increase the hypotensive activities of Manidipine.Approved
NitrendipineNitrendipine may increase the hypotensive activities of Manidipine.Approved, Investigational
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Manidipine.Approved, Investigational, Vet Approved
NitroprussideManidipine may increase the hypotensive activities of Nitroprusside.Approved
NitroxolineThe risk or severity of adverse effects can be increased when Nitroxoline is combined with Manidipine.Approved
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Manidipine.Approved
NystatinThe risk or severity of adverse effects can be increased when Nystatin is combined with Manidipine.Approved, Vet Approved
ObinutuzumabManidipine may increase the hypotensive activities of Obinutuzumab.Approved
OctamoxinOctamoxin may increase the hypotensive activities of Manidipine.Withdrawn
OlanzapineThe metabolism of Olanzapine can be decreased when combined with Manidipine.Approved, Investigational
OleandomycinThe metabolism of Manidipine can be decreased when combined with Oleandomycin.Vet Approved
OlmesartanOlmesartan may increase the hypotensive activities of Manidipine.Approved, Investigational
OlodaterolThe metabolism of Olodaterol can be decreased when combined with Manidipine.Approved
OmapatrilatOmapatrilat may increase the hypotensive activities of Manidipine.Investigational
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Manidipine.Approved, Investigational, Vet Approved
OmoconazoleThe risk or severity of adverse effects can be increased when Omoconazole is combined with Manidipine.Experimental
OndansetronThe metabolism of Ondansetron can be decreased when combined with Manidipine.Approved
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Manidipine.Approved
OxaprozinThe metabolism of Oxaprozin can be decreased when combined with Manidipine.Approved
OxiconazoleThe risk or severity of adverse effects can be increased when Oxiconazole is combined with Manidipine.Approved
OxprenololOxprenolol may increase the hypotensive activities of Manidipine.Approved
OxycodoneThe metabolism of Oxycodone can be decreased when combined with Manidipine.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Manidipine.Approved, Investigational, Vet Approved
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Manidipine.Approved, Vet Approved
pafuramidineThe risk or severity of adverse effects can be increased when pafuramidine is combined with Manidipine.Investigational
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Manidipine.Approved, Investigational
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Manidipine.Approved
ParecoxibThe metabolism of Parecoxib can be decreased when combined with Manidipine.Approved
PargylinePargyline may increase the hypotensive activities of Manidipine.Approved
ParoxetineThe metabolism of Paroxetine can be decreased when combined with Manidipine.Approved, Investigational
PazopanibThe metabolism of Pazopanib can be decreased when combined with Manidipine.Approved
PenbutololPenbutolol may increase the hypotensive activities of Manidipine.Approved, Investigational
PentamidineThe risk or severity of adverse effects can be increased when Pentamidine is combined with Manidipine.Approved
PentobarbitalThe metabolism of Manidipine can be increased when combined with Pentobarbital.Approved, Vet Approved
PentoliniumPentolinium may increase the hypotensive activities of Manidipine.Approved
PentoxifyllinePentoxifylline may increase the hypotensive activities of Manidipine.Approved, Investigational
PergolideThe risk or severity of adverse effects can be increased when Pergolide is combined with Manidipine.Approved, Investigational, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Manidipine.Approved, Investigational
PerindoprilPerindopril may increase the hypotensive activities of Manidipine.Approved
PerospironeThe metabolism of Perospirone can be decreased when combined with Manidipine.Approved
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Manidipine.Approved
PethidineThe metabolism of Pethidine can be decreased when combined with Manidipine.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Manidipine.Withdrawn
PhenelzinePhenelzine may increase the hypotensive activities of Manidipine.Approved
PhenforminThe metabolism of Phenformin can be decreased when combined with Manidipine.Approved, Investigational, Withdrawn
PheniprazinePheniprazine may increase the hypotensive activities of Manidipine.Withdrawn
PhenobarbitalThe metabolism of Manidipine can be increased when combined with Phenobarbital.Approved
PhenoxybenzaminePhenoxybenzamine may increase the hypotensive activities of Manidipine.Approved
PhenoxypropazinePhenoxypropazine may increase the hypotensive activities of Manidipine.Withdrawn
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Manidipine.Approved, Investigational
PhentolaminePhentolamine may increase the hypotensive activities of Manidipine.Approved
PhenylbutazoneThe metabolism of Phenylbutazone can be decreased when combined with Manidipine.Approved, Vet Approved
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Manidipine.Approved, Vet Approved
PinacidilPinacidil may increase the hypotensive activities of Manidipine.Withdrawn
PindololPindolol may increase the hypotensive activities of Manidipine.Approved
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Manidipine.Approved, Investigational
PiperazineThe metabolism of Piperazine can be decreased when combined with Manidipine.Approved, Vet Approved
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Manidipine.Approved, Investigational
PirlindolePirlindole may increase the hypotensive activities of Manidipine.Approved
PiroxicamThe metabolism of Piroxicam can be decreased when combined with Manidipine.Approved, Investigational
PitavastatinThe metabolism of Pitavastatin can be decreased when combined with Manidipine.Approved
PivhydrazinePivhydrazine may increase the hypotensive activities of Manidipine.Withdrawn
Platelet Activating FactorPlatelet Activating Factor may increase the hypotensive activities of Manidipine.Experimental
PolythiazidePolythiazide may increase the hypotensive activities of Manidipine.Approved
PonatinibThe metabolism of Ponatinib can be decreased when combined with Manidipine.Approved
PosaconazoleThe risk or severity of adverse effects can be increased when Posaconazole is combined with Manidipine.Approved, Investigational, Vet Approved
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Manidipine.Approved
PravastatinThe metabolism of Pravastatin can be decreased when combined with Manidipine.Approved
PrazosinPrazosin may increase the hypotensive activities of Manidipine.Approved
PrimidoneThe metabolism of Manidipine can be increased when combined with Primidone.Approved, Vet Approved
ProcainamideThe metabolism of Procainamide can be decreased when combined with Manidipine.Approved
ProcarbazineProcarbazine may increase the hypotensive activities of Manidipine.Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Manidipine.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Manidipine.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Manidipine.Approved
PromazineThe metabolism of Promazine can be decreased when combined with Manidipine.Approved, Vet Approved
PromethazineThe metabolism of Promethazine can be decreased when combined with Manidipine.Approved
PropafenoneThe serum concentration of Manidipine can be increased when it is combined with Propafenone.Approved
PropofolThe metabolism of Propofol can be decreased when combined with Manidipine.Approved, Investigational, Vet Approved
PropranololPropranolol may increase the hypotensive activities of Manidipine.Approved, Investigational
ProtriptylineThe metabolism of Protriptyline can be decreased when combined with Manidipine.Approved
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Manidipine.Approved
PyrrolnitrinThe risk or severity of adverse effects can be increased when Pyrrolnitrin is combined with Manidipine.Experimental
QuazepamThe metabolism of Quazepam can be decreased when combined with Manidipine.Approved, Illicit
QuetiapineThe metabolism of Quetiapine can be decreased when combined with Manidipine.Approved
QuinaprilQuinapril may increase the hypotensive activities of Manidipine.Approved, Investigational
QuinidineThe metabolism of Quinidine can be decreased when combined with Manidipine.Approved
QuinineQuinine may increase the hypotensive activities of Manidipine.Approved
RadicicolThe risk or severity of adverse effects can be increased when Radicicol is combined with Manidipine.Experimental
RamiprilRamipril may increase the hypotensive activities of Manidipine.Approved
RanitidineThe metabolism of Ranitidine can be decreased when combined with Manidipine.Approved
RapacuroniumManidipine may increase the neuromuscular blocking activities of Rapacuronium.Withdrawn
RasagilineRasagiline may increase the hypotensive activities of Manidipine.Approved
RemikirenRemikiren may increase the hypotensive activities of Manidipine.Approved
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Manidipine.Approved, Withdrawn
repinotanThe metabolism of repinotan can be decreased when combined with Manidipine.Investigational
RescinnamineManidipine may increase the hypotensive activities of Rescinnamine.Approved
ReserpineReserpine may increase the hypotensive activities of Manidipine.Approved, Investigational
RifabutinThe serum concentration of Manidipine can be decreased when it is combined with Rifabutin.Approved
RifampicinThe serum concentration of Manidipine can be decreased when it is combined with Rifampicin.Approved
RifapentineThe serum concentration of Manidipine can be decreased when it is combined with Rifapentine.Approved
RifaximinThe serum concentration of Manidipine can be decreased when it is combined with Rifaximin.Approved, Investigational
RilmenidineRilmenidine may increase the hypotensive activities of Manidipine.Investigational
RiociguatManidipine may increase the hypotensive activities of Riociguat.Approved
RisperidoneThe metabolism of Risperidone can be decreased when combined with Manidipine.Approved, Investigational
RitonavirThe metabolism of Ritonavir can be decreased when combined with Manidipine.Approved, Investigational
RituximabManidipine may increase the hypotensive activities of Rituximab.Approved
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Manidipine.Investigational, Withdrawn
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Manidipine.Approved
RosiglitazoneThe metabolism of Rosiglitazone can be decreased when combined with Manidipine.Approved, Investigational
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Manidipine.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Manidipine.Approved
RucaparibThe metabolism of Rucaparib can be decreased when combined with Manidipine.Approved, Investigational
RupatadineThe metabolism of Rupatadine can be decreased when combined with Manidipine.Approved
SafrazineSafrazine may increase the hypotensive activities of Manidipine.Withdrawn
Salicylhydroxamic AcidThe risk or severity of adverse effects can be increased when Salicylhydroxamic Acid is combined with Manidipine.Experimental
Salicylic acidThe risk or severity of adverse effects can be increased when Salicylic acid is combined with Manidipine.Approved, Vet Approved
SaprisartanSaprisartan may increase the hypotensive activities of Manidipine.Experimental
SaquinavirThe metabolism of Saquinavir can be decreased when combined with Manidipine.Approved, Investigational
SecobarbitalThe metabolism of Manidipine can be increased when combined with Secobarbital.Approved, Vet Approved
SelegilineSelegiline may increase the hypotensive activities of Manidipine.Approved, Investigational, Vet Approved
SelexipagManidipine may increase the hypotensive activities of Selexipag.Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Manidipine.Approved
SertaconazoleThe risk or severity of adverse effects can be increased when Sertaconazole is combined with Manidipine.Approved
SertindoleThe metabolism of Sertindole can be decreased when combined with Manidipine.Approved, Investigational, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Manidipine.Approved
SildenafilSildenafil may increase the antihypertensive activities of Manidipine.Approved, Investigational
SilodosinSilodosin may increase the hypotensive activities of Manidipine.Approved
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Manidipine.Approved
SinefunginThe risk or severity of adverse effects can be increased when Sinefungin is combined with Manidipine.Experimental
SirolimusThe risk or severity of adverse effects can be increased when Sirolimus is combined with Manidipine.Approved, Investigational
SitaxentanManidipine may increase the hypotensive activities of Sitaxentan.Approved, Investigational, Withdrawn
SolithromycinThe metabolism of Manidipine can be decreased when combined with Solithromycin.Investigational
SparteineThe metabolism of Sparteine can be decreased when combined with Manidipine.Experimental
SpiraprilSpirapril may increase the hypotensive activities of Manidipine.Approved
SulconazoleThe risk or severity of adverse effects can be increased when Sulconazole is combined with Manidipine.Approved
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Manidipine.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Manidipine.Approved
SulfamoxoleThe metabolism of Sulfamoxole can be decreased when combined with Manidipine.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Manidipine.Approved
SulfisoxazoleThe metabolism of Sulfisoxazole can be decreased when combined with Manidipine.Approved, Vet Approved
SuprofenThe metabolism of Suprofen can be decreased when combined with Manidipine.Approved, Withdrawn
TadalafilTadalafil may increase the antihypertensive activities of Manidipine.Approved, Investigational
TalinololManidipine may increase the hypotensive activities of Talinolol.Investigational
TamoxifenThe serum concentration of the active metabolites of Tamoxifen can be reduced when Tamoxifen is used in combination with Manidipine resulting in a loss in efficacy.Approved
TamsulosinTamsulosin may increase the hypotensive activities of Manidipine.Approved, Investigational
TapentadolThe metabolism of Tapentadol can be decreased when combined with Manidipine.Approved
TavaboroleThe risk or severity of adverse effects can be increased when Tavaborole is combined with Manidipine.Approved
TegaserodThe metabolism of Tegaserod can be decreased when combined with Manidipine.Investigational, Withdrawn
TelithromycinThe metabolism of Manidipine can be decreased when combined with Telithromycin.Approved
TelmisartanTelmisartan may increase the hypotensive activities of Manidipine.Approved, Investigational
TemazepamThe metabolism of Temazepam can be decreased when combined with Manidipine.Approved
TemocaprilTemocapril may increase the hypotensive activities of Manidipine.Experimental, Investigational
TenoxicamThe metabolism of Tenoxicam can be decreased when combined with Manidipine.Approved
TerazosinTerazosin may increase the hypotensive activities of Manidipine.Approved
TerbinafineThe risk or severity of adverse effects can be increased when Terbinafine is combined with Manidipine.Approved, Investigational, Vet Approved
TerconazoleThe risk or severity of adverse effects can be increased when Terconazole is combined with Manidipine.Approved
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Manidipine.Withdrawn
TergurideThe risk or severity of adverse effects can be increased when Terguride is combined with Manidipine.Experimental
TerlipressinTerlipressin may increase the hypotensive activities of Manidipine.Approved, Investigational
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Manidipine.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Manidipine.Approved, Investigational
TetrabenazineThe metabolism of Tetrabenazine can be decreased when combined with Manidipine.Approved
TetrahydropalmatineManidipine may increase the hypotensive activities of Tetrahydropalmatine.Investigational
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Manidipine.Approved, Investigational, Withdrawn
TheodrenalineManidipine may increase the hypotensive activities of Theodrenaline.Investigational
TheophyllineThe metabolism of Theophylline can be decreased when combined with Manidipine.Approved
ThiamylalThe metabolism of Manidipine can be increased when combined with Thiamylal.Approved, Vet Approved
ThiopentalThe metabolism of Manidipine can be increased when combined with Thiopental.Approved, Vet Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Manidipine.Approved, Withdrawn
ThymolThe risk or severity of adverse effects can be increased when Thymol is combined with Manidipine.Approved
TiboloneTibolone may increase the hypotensive activities of Manidipine.Approved, Investigational
TiclopidineThe metabolism of Ticlopidine can be decreased when combined with Manidipine.Approved
TicrynafenTicrynafen may increase the hypotensive activities of Manidipine.Withdrawn
TimololTimolol may increase the hypotensive activities of Manidipine.Approved
TioconazoleThe risk or severity of adverse effects can be increased when Tioconazole is combined with Manidipine.Approved
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Manidipine.Approved
TipranavirThe metabolism of Tipranavir can be decreased when combined with Manidipine.Approved, Investigational
TizanidineThe serum concentration of Tizanidine can be increased when it is combined with Manidipine.Approved
TolazolineTolazoline may increase the hypotensive activities of Manidipine.Approved, Vet Approved
TolbutamideThe metabolism of Tolbutamide can be decreased when combined with Manidipine.Approved
TolciclateThe risk or severity of adverse effects can be increased when Tolciclate is combined with Manidipine.Experimental
TolnaftateThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Manidipine.Approved, Vet Approved
TolonidineManidipine may increase the hypotensive activities of Tolonidine.Experimental
ToloxatoneToloxatone may increase the hypotensive activities of Manidipine.Approved
TolterodineThe metabolism of Tolterodine can be decreased when combined with Manidipine.Approved, Investigational
TorasemideTorasemide may increase the hypotensive activities of Manidipine.Approved
TrabectedinThe metabolism of Trabectedin can be decreased when combined with Manidipine.Approved, Investigational
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Manidipine.Approved, Investigational
TrandolaprilTrandolapril may increase the hypotensive activities of Manidipine.Approved
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the hypotensive activities of Manidipine.Experimental
TranylcypromineTranylcypromine may increase the hypotensive activities of Manidipine.Approved
TravoprostTravoprost may increase the hypotensive activities of Manidipine.Approved
TrazodoneThe metabolism of Trazodone can be decreased when combined with Manidipine.Approved, Investigational
TreprostinilTreprostinil may increase the hypotensive activities of Manidipine.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Manidipine.Approved, Investigational, Nutraceutical
TrichlormethiazideTrichlormethiazide may increase the hypotensive activities of Manidipine.Approved, Vet Approved
TrimazosinTrimazosin may increase the hypotensive activities of Manidipine.Experimental
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Manidipine.Approved
TrimethaphanTrimethaphan may increase the hypotensive activities of Manidipine.Approved, Investigational
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Manidipine.Approved, Vet Approved
TrimetrexateThe risk or severity of adverse effects can be increased when Trimetrexate is combined with Manidipine.Approved, Investigational
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Manidipine.Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Manidipine.Investigational, Withdrawn
TylosinThe metabolism of Manidipine can be decreased when combined with Tylosin.Vet Approved
UbidecarenoneThe serum concentration of Ubidecarenone can be increased when it is combined with Manidipine.Approved, Investigational, Nutraceutical
UdenafilUdenafil may increase the antihypertensive activities of Manidipine.Approved, Investigational
UmeclidiniumThe metabolism of Umeclidinium can be decreased when combined with Manidipine.Approved
UnoprostoneUnoprostone may increase the hypotensive activities of Manidipine.Approved
UrapidilUrapidil may increase the hypotensive activities of Manidipine.Investigational
ValbenazineThe metabolism of Valbenazine can be decreased when combined with Manidipine.Approved, Investigational
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Manidipine.Investigational, Withdrawn
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Manidipine.Approved, Investigational
ValsartanValsartan may increase the hypotensive activities of Manidipine.Approved, Investigational
VardenafilVardenafil may increase the antihypertensive activities of Manidipine.Approved
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Manidipine.Approved
VerapamilThe metabolism of Verapamil can be decreased when combined with Manidipine.Approved
VernakalantThe metabolism of Vernakalant can be decreased when combined with Manidipine.Approved, Investigational
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Manidipine.Investigational
VilazodoneThe metabolism of Vilazodone can be decreased when combined with Manidipine.Approved
VinblastineThe metabolism of Vinblastine can be decreased when combined with Manidipine.Approved
VincamineManidipine may increase the hypotensive activities of Vincamine.Experimental
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Manidipine.Approved, Investigational
VinpocetineManidipine may increase the hypotensive activities of Vinpocetine.Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Manidipine.Approved
VoriconazoleThe risk or severity of adverse effects can be increased when Voriconazole is combined with Manidipine.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Manidipine.Approved
WarfarinThe metabolism of Warfarin can be decreased when combined with Manidipine.Approved
XimelagatranThe metabolism of Ximelagatran can be decreased when combined with Manidipine.Approved, Investigational, Withdrawn
XipamideManidipine may increase the hypotensive activities of Xipamide.Experimental
XylometazolineXylometazoline may increase the hypotensive activities of Manidipine.Approved
YohimbineYohimbine may decrease the antihypertensive activities of Manidipine.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Manidipine.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Manidipine.Approved, Investigational
ZaltoprofenThe metabolism of Zaltoprofen can be decreased when combined with Manidipine.Approved, Investigational
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Manidipine.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Manidipine.Approved, Investigational, Withdrawn
ZofenoprilManidipine may increase the hypotensive activities of Zofenopril.Experimental
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Manidipine.Approved
ZopicloneThe metabolism of Zopiclone can be decreased when combined with Manidipine.Approved
ZuclopenthixolThe metabolism of Zuclopenthixol can be decreased when combined with Manidipine.Approved, Investigational
Food Interactions
Not Available

References

General References
  1. Cheer SM, McClellan K: Manidipine: a review of its use in hypertension. Drugs. 2001;61(12):1777-99. [PubMed:11693466]
  2. McKeage K, Scott LJ: Manidipine: a review of its use in the management of hypertension. Drugs. 2004;64(17):1923-40. [PubMed:15329044]
External Links
PubChem Compound
4008
PubChem Substance
347827830
ChemSpider
3868
ChEBI
135849
ChEMBL
CHEMBL1085699
Wikipedia
Manidipine
ATC Codes
C08CA11 — ManidipineC09BB12 — Delapril and manidipine

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedTreatmentHigh Blood Pressure (Hypertension)1
4RecruitingTreatmentCardiovascular Disease (CVD) / Chronic Kidney Disease (CKD) / Hypertension,Essential / Strokes1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
water solubility<1mg/mLMSDS
Predicted Properties
PropertyValueSource
Water Solubility0.000995 mg/mLALOGPS
logP5.11ALOGPS
logP5.19ChemAxon
logS-5.8ALOGPS
pKa (Strongest Acidic)19.47ChemAxon
pKa (Strongest Basic)7.89ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area116.93 Å2ChemAxon
Rotatable Bond Count12ChemAxon
Refractivity175.13 m3·mol-1ChemAxon
Polarizability65.72 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Diphenylmethanes
Direct Parent
Diphenylmethanes
Alternative Parents
Dihydropyridinecarboxylic acids and derivatives / Nitrobenzenes / Nitroaromatic compounds / Aralkylamines / N-alkylpiperazines / Dicarboxylic acids and derivatives / Vinylogous amides / Enoate esters / Methyl esters / Amino acids and derivatives
show 11 more
Substituents
Diphenylmethane / Dihydropyridinecarboxylic acid derivative / Nitrobenzene / Nitroaromatic compound / Dihydropyridine / Aralkylamine / N-alkylpiperazine / 1,4-diazinane / Dicarboxylic acid or derivatives / Hydropyridine
show 32 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
Not Available

Targets

Kind
Protein group
Organism
Human
Pharmacological action
Yes
Actions
Blocker
General Function
Voltage-gated calcium channel activity
Specific Function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hor...

Components:
References
  1. McKeage K, Scott LJ: Manidipine: a review of its use in the management of hypertension. Drugs. 2004;64(17):1923-40. [PubMed:15329044]
Kind
Protein group
Organism
Homo sapiens
Pharmacological action
Yes
Actions
Blocker
General Function
Scaffold protein binding
Specific Function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hor...

Components:
References
  1. McKeage K, Scott LJ: Manidipine: a review of its use in the management of hypertension. Drugs. 2004;64(17):1923-40. [PubMed:15329044]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C9
Uniprot ID
P11712
Uniprot Name
Cytochrome P450 2C9
Molecular Weight
55627.365 Da
References
  1. McKeage K, Scott LJ: Manidipine: a review of its use in the management of hypertension. Drugs. 2004;64(17):1923-40. [PubMed:15329044]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
Gene Name
CYP2D6
Uniprot ID
P10635
Uniprot Name
Cytochrome P450 2D6
Molecular Weight
55768.94 Da
References
  1. McKeage K, Scott LJ: Manidipine: a review of its use in the management of hypertension. Drugs. 2004;64(17):1923-40. [PubMed:15329044]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Vitamin d 24-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A1
Uniprot ID
P04798
Uniprot Name
Cytochrome P450 1A1
Molecular Weight
58164.815 Da
References
  1. McKeage K, Scott LJ: Manidipine: a review of its use in the management of hypertension. Drugs. 2004;64(17):1923-40. [PubMed:15329044]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A2
Uniprot ID
P05177
Uniprot Name
Cytochrome P450 1A2
Molecular Weight
58293.76 Da
References
  1. McKeage K, Scott LJ: Manidipine: a review of its use in the management of hypertension. Drugs. 2004;64(17):1923-40. [PubMed:15329044]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2B6
Uniprot ID
P20813
Uniprot Name
Cytochrome P450 2B6
Molecular Weight
56277.81 Da
References
  1. McKeage K, Scott LJ: Manidipine: a review of its use in the management of hypertension. Drugs. 2004;64(17):1923-40. [PubMed:15329044]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and im...
Gene Name
CYP2C19
Uniprot ID
P33261
Uniprot Name
Cytochrome P450 2C19
Molecular Weight
55930.545 Da
References
  1. McKeage K, Scott LJ: Manidipine: a review of its use in the management of hypertension. Drugs. 2004;64(17):1923-40. [PubMed:15329044]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. McKeage K, Scott LJ: Manidipine: a review of its use in the management of hypertension. Drugs. 2004;64(17):1923-40. [PubMed:15329044]

Drug created on October 23, 2015 10:51 / Updated on December 01, 2017 16:14