Tapentadol hydrochloride: A novel analgesic.

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Singh DR, Nag K, Shetti AN, Krishnaveni N

Tapentadol hydrochloride: A novel analgesic.

Saudi J Anaesth. 2013 Jul;7(3):322-6. doi: 10.4103/1658-354X.115319.

PubMed ID

24015138 [ View in PubMed

]

Abstract

Tapentadol is a novel, centrally acting analgesic with dual mechanism of action, combining mu-opioid receptor agonism with noradrenaline reuptake inhibition in the same molecule. It has an improved side effect profile when compared to opioids and nonsteroidal anti-inflammatory drugs. The dual mechanism of action makes Tapentadol a useful analgesic to treat acute, chronic, and neuropathic pain.

DrugBank Data that Cites this Article

Drugs

Tapentadol

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Tapentadol	Delta-type opioid receptor	Protein	Humans	Unknown	Agonist	Details
Tapentadol	Kappa-type opioid receptor	Protein	Humans	Unknown	Agonist	Details
Tapentadol	Mu-type opioid receptor	Protein	Humans	Unknown	Agonist	Details
Tapentadol	Sodium-dependent noradrenaline transporter	Protein	Humans	Unknown	Inhibitor	Details

Drug Interactions

Drugs	Interaction
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Tapentadol Linezolid	The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Tapentadol.
Tapentadol Furazolidone	The risk or severity of serotonin syndrome can be increased when Furazolidone is combined with Tapentadol.
Tapentadol Tranylcypromine	The risk or severity of serotonin syndrome can be increased when Tranylcypromine is combined with Tapentadol.
Tapentadol Phenelzine	The risk or severity of serotonin syndrome can be increased when Phenelzine is combined with Tapentadol.
Tapentadol Minaprine	The risk or severity of serotonin syndrome can be increased when Minaprine is combined with Tapentadol.