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IdentificationPharmacologyInteractionsReferencesTrialsEconomicsPropertiesSpectraTaxonomyFurazolidone
Targets (1)
Enzymes (2)
Identification
- Name
- Furazolidone
- Accession Number
- DB00614 (APRD00988)
- Type
- Small Molecule
- Groups
- Approved, Vet Approved
- Description
A nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone binds bacterial DNA which leads to the gradual inhibition of monoamine oxidase. (From Martindale, The Extra Pharmacopoeia, 30th ed, p514)
- Structure
Structure for DB00614 (Furazolidone)
- Synonyms
- 3-(5'-Nitrofurfuralamino)-2-oxazolidone
- 3-[(5-Nitrofurfurylidene)amino]-2-oxazolidinone
- 3-[(5-Nitrofurfurylidene)amino]-2-oxazolidone
- 3-[(5-Nitrofurylidene)amino]-2-oxazolidone
- 3-{[(5-nitro-2-furanyl)methylene]amino}-2-oxazolidinone
- 5-Nitro-N-(2-oxo-3-oxazolidinyl)-2-furanmethanimine
- Furazolidona
- Furazolidone
- Furazolidonum
- FZL
- N-(5-Nitro-2-furfurylidene)-3-amino-2-oxazolidone
- N-(5-Nitro-2-furfurylidene)-3-aminooxazolidine-2-one
- Nitrofurazolidone
- Nitrofurazolidonum
- External IDs
- USAF EA-1
- Product Ingredients
- Not Available
- Approved Prescription Products
- Not Available
- Approved Generic Prescription Products
- Not Available
- Approved Over the Counter Products
- Not Available
- Unapproved/Other Products
- Not Available
- International/Other Brands
- Dependal-M (GlaxoSmithKline) / Furoxone (Roberts Laboratories)
- Brand mixtures
- Not Available
- Categories
- Anti-Infective Agents
- Anti-Infective Agents, Local
- Anti-Infective Agents, Urinary
- Antiparasitic Agents
- Antiprotozoals
- Antitrichomonal Agents
- Enzyme Inhibitors
- Furans
- Genito Urinary System and Sex Hormones
- Gynecological Antiinfectives and Antiseptics
- Monoamine Oxidase Inhibitors
- Nitro Compounds
- Nitrofurans
- Oxazoles
- Oxazolidinones
- Renal Agents
- UNII
- 5J9CPU3RE0
- CAS number
- 67-45-8
- Weight
- Average: 225.1583
Monoisotopic: 225.038570349 - Chemical Formula
- C8H7N3O5
- InChI Key
- PLHJDBGFXBMTGZ-WEVVVXLNSA-N
- InChI
- InChI=1S/C8H7N3O5/c12-8-10(3-4-15-8)9-5-6-1-2-7(16-6)11(13)14/h1-2,5H,3-4H2/b9-5+
- IUPAC Name
- 3-{[(5-nitrofuran-2-yl)methylidene]amino}-1,3-oxazolidin-2-one
- SMILES
- [O-][N+](=O)C1=CC=C(O1)C=NN1CCOC1=O
Pharmacology
- Indication
For the specific and symptomatic treatment of bacterial or protozoal diarrhea and enteritis caused by susceptible organisms.
- Structured Indications
- Not Available
- Pharmacodynamics
Furoxone has a broad antibacterial spectrum covering the majority of gastrointestinal tract pathogens including E. coli, staphylococci, Salmonella, Shigella, Proteus, Aerobacter aerogenes, Vibrio cholerae and Giardia lamblia. Its bactericidal activity is based upon its interference with DNA replication and protein production; this antimicrobial action minimizes the development of resistant organisms.
- Mechanism of action
Furazolidone and its related free radical products are believed to bind DNA and induce cross-links. Bacterial DNA is particularly susceptible to this drug leading to high levels of mutations (transitions and transversions) in the bacterial chromosome.
Target Actions Organism ADNA cross-linking/alkylationHuman - Absorption
Radiolabeled drug studies indicate that furazolidone is well absorbed following oral administration
- Volume of distribution
- Not Available
- Protein binding
- Not Available
- Metabolism
Furazolidone is rapidly and extensively metabolized; the primary metabolic pathway identified begins with nitro-reduction to the aminofuran derivative. Two major metabolites are produced: 3-amino-2-oxazolidone (AOZ) or beta-hydroxyethylhydrazine (HEH). AOZ is responsible for monoamine oxidase inhibition. Detoxification and elimination of the drug is done primarily by conjugation with glutathione.
- Route of elimination
- Not Available
- Half life
10 minutes
- Clearance
- Not Available
- Toxicity
Reactions to Furoxone have been reported including a fall in blood pressure, urticaria, fever, arthralgia, and a vesicular morbilliform rash. Other adverse effects can include a brown discoloration of the urine; hemolysis can occur in G6PDH-deficient patients. The drug has a monoamine oxidase (MAO) inhibitory effect and should never be given concurrently to individuals already taking MAO inhibitors.
- Affected organisms
- Microbes (bacteria, parasites)
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
Drug Interaction Drug group 2,5-Dimethoxy-4-ethylamphetamine Furazolidone may increase the hypertensive activities of 2,5-Dimethoxy-4-ethylamphetamine. Experimental, Illicit 3,4-Methylenedioxyamphetamine Furazolidone may increase the hypertensive activities of 3,4-Methylenedioxyamphetamine. Experimental, Illicit 3,4-Methylenedioxymethamphetamine Furazolidone may increase the hypertensive activities of 3,4-Methylenedioxymethamphetamine. Experimental, Illicit 4-Bromo-2,5-dimethoxyamphetamine Furazolidone may increase the hypertensive activities of 4-Bromo-2,5-dimethoxyamphetamine. Experimental, Illicit 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline Furazolidone may increase the hypertensive activities of 7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE. Experimental Acarbose Furazolidone may increase the hypoglycemic activities of Acarbose. Approved, Investigational Acebutolol Furazolidone may increase the hypotensive activities of Acebutolol. Approved Albiglutide Furazolidone may increase the hypoglycemic activities of Albiglutide. Approved Alfentanil Alfentanil may increase the serotonergic activities of Furazolidone. Approved, Illicit Aliskiren Furazolidone may increase the hypotensive activities of Aliskiren. Approved, Investigational Almotriptan The metabolism of Almotriptan can be decreased when combined with Furazolidone. Approved, Investigational Alogliptin Furazolidone may increase the hypoglycemic activities of Alogliptin. Approved Alprenolol Furazolidone may increase the hypotensive activities of Alprenolol. Approved, Withdrawn Altretamine Altretamine may increase the orthostatic hypotensive activities of Furazolidone. Approved Ambrisentan Furazolidone may increase the hypotensive activities of Ambrisentan. Approved, Investigational Amineptine Furazolidone may increase the serotonergic activities of Amineptine. Illicit, Withdrawn Amitriptyline Furazolidone may increase the serotonergic activities of Amitriptyline. Approved Amlodipine Furazolidone may increase the hypotensive activities of Amlodipine. Approved Amoxapine The risk or severity of adverse effects can be increased when Furazolidone is combined with Amoxapine. Approved Amphetamine Furazolidone may increase the hypertensive activities of Amphetamine. Approved, Illicit Apomorphine The metabolism of Apomorphine can be decreased when combined with Furazolidone. Approved, Investigational Apraclonidine The risk or severity of adverse effects can be increased when Furazolidone is combined with Apraclonidine. Approved Arbutamine The risk or severity of adverse effects can be increased when Furazolidone is combined with Arbutamine. Approved Arformoterol The risk or severity of adverse effects can be increased when Furazolidone is combined with Arformoterol. Approved, Investigational Atenolol Furazolidone may increase the hypotensive activities of Atenolol. Approved Atomoxetine Furazolidone may increase the central neurotoxic activities of Atomoxetine. Approved Atropine Furazolidone may increase the hypertensive activities of Atropine. Approved, Vet Approved Bambuterol The risk or severity of adverse effects can be increased when Furazolidone is combined with Bambuterol. Approved Benazepril Furazolidone may increase the hypotensive activities of Benazepril. Approved, Investigational Bendroflumethiazide Furazolidone may increase the hypotensive activities of Bendroflumethiazide. Approved Benmoxin Furazolidone may increase the hypertensive activities of Benmoxin. Withdrawn Benzphetamine Furazolidone may increase the hypertensive activities of Benzphetamine. Approved, Illicit Bepridil Furazolidone may increase the hypotensive activities of Bepridil. Approved, Withdrawn Betahistine The serum concentration of Betahistine can be increased when it is combined with Furazolidone. Approved Betaxolol Furazolidone may increase the hypotensive activities of Betaxolol. Approved Bethanidine Furazolidone may increase the hypotensive activities of Bethanidine. Approved Bezafibrate The risk or severity of adverse effects can be increased when Furazolidone is combined with Bezafibrate. Approved Bimatoprost Furazolidone may increase the hypotensive activities of Bimatoprost. Approved, Investigational Bisoprolol Furazolidone may increase the hypotensive activities of Bisoprolol. Approved Bosentan Furazolidone may increase the hypotensive activities of Bosentan. Approved, Investigational Bretylium Furazolidone may increase the hypotensive activities of Bretylium. Approved Brimonidine Furazolidone may increase the hypotensive activities of Brimonidine. Approved Brimonidine The risk or severity of adverse effects can be increased when Furazolidone is combined with Brimonidine. Approved Bromocriptine The metabolism of Bromocriptine can be decreased when combined with Furazolidone. Approved, Investigational Bupranolol Furazolidone may increase the hypotensive activities of Bupranolol. Approved Buprenorphine The risk or severity of adverse effects can be increased when Buprenorphine is combined with Furazolidone. Approved, Illicit, Investigational, Vet Approved Bupropion Furazolidone may increase the hypertensive activities of Bupropion. Approved Buspirone The risk or severity of adverse effects can be increased when Buspirone is combined with Furazolidone. Approved, Investigational Cabergoline The metabolism of Cabergoline can be decreased when combined with Furazolidone. Approved Canagliflozin Furazolidone may increase the hypoglycemic activities of Canagliflozin. Approved Candesartan Furazolidone may increase the hypotensive activities of Candesartan. Approved Candoxatril Furazolidone may increase the hypotensive activities of Candoxatril. Experimental Captopril Furazolidone may increase the hypotensive activities of Captopril. Approved Carbamazepine The risk or severity of adverse effects can be increased when Carbamazepine is combined with Furazolidone. Approved, Investigational Caroxazone Furazolidone may increase the hypertensive activities of Caroxazone. Withdrawn Carteolol Furazolidone may increase the hypotensive activities of Carteolol. Approved Carvedilol Furazolidone may increase the hypotensive activities of Carvedilol. Approved, Investigational Celiprolol Furazolidone may increase the hypotensive activities of Celiprolol. Approved, Investigational Chlorothiazide Furazolidone may increase the hypotensive activities of Chlorothiazide. Approved, Vet Approved Chlorphentermine Furazolidone may increase the hypertensive activities of Chlorphentermine. Illicit, Withdrawn Chlorpropamide Furazolidone may increase the hypoglycemic activities of Chlorpropamide. Approved Chlorthalidone Furazolidone may increase the hypotensive activities of Chlorthalidone. Approved Cilazapril Furazolidone may increase the hypotensive activities of Cilazapril. Approved Cirazoline Furazolidone may increase the hypertensive activities of Cirazoline. Experimental Citalopram Furazolidone may increase the serotonergic activities of Citalopram. Approved Clemastine Furazolidone may increase the anticholinergic activities of Clemastine. Approved Clenbuterol The risk or severity of adverse effects can be increased when Furazolidone is combined with Clenbuterol. Approved, Vet Approved Clomipramine Furazolidone may increase the serotonergic activities of Clomipramine. Approved, Vet Approved Clonidine Furazolidone may increase the hypotensive activities of Clonidine. Approved Cryptenamine Furazolidone may increase the hypotensive activities of Cryptenamine. Approved Cyclobenzaprine Cyclobenzaprine may increase the serotonergic activities of Furazolidone. Approved Cyclothiazide Furazolidone may increase the hypotensive activities of Cyclothiazide. Approved Cyproheptadine Furazolidone may increase the anticholinergic activities of Cyproheptadine. Approved Dapagliflozin Furazolidone may increase the hypoglycemic activities of Dapagliflozin. Approved Dapoxetine Furazolidone may increase the serotonergic activities of Dapoxetine. Investigational Debrisoquin Furazolidone may increase the hypotensive activities of Debrisoquin. Approved Deserpidine Furazolidone may increase the hypotensive activities of Deserpidine. Approved Desipramine Furazolidone may increase the serotonergic activities of Desipramine. Approved Desvenlafaxine Furazolidone may increase the serotonergic activities of Desvenlafaxine. Approved Dexmethylphenidate Furazolidone may increase the hypertensive activities of Dexmethylphenidate. Approved Dextroamphetamine Furazolidone may increase the hypertensive activities of Dextroamphetamine. Approved, Illicit Dextromethorphan Furazolidone may increase the serotonergic activities of Dextromethorphan. Approved Diazoxide Furazolidone may increase the hypotensive activities of Diazoxide. Approved Diethylpropion Furazolidone may increase the hypertensive activities of Diethylpropion. Approved, Illicit Dihydralazine Furazolidone may increase the hypotensive activities of Dihydralazine. Investigational Dihydroergotamine The metabolism of Dihydroergotamine can be decreased when combined with Furazolidone. Approved Diltiazem Furazolidone may increase the hypotensive activities of Diltiazem. Approved Dipivefrin The risk or severity of adverse effects can be increased when Furazolidone is combined with Dipivefrin. Approved Disopyramide Furazolidone may increase the hypoglycemic activities of Disopyramide. Approved Dobutamine The risk or severity of adverse effects can be increased when Furazolidone is combined with Dobutamine. Approved Domperidone The risk or severity of adverse effects can be increased when Furazolidone is combined with Domperidone. Approved, Investigational, Vet Approved Dorzolamide Furazolidone may increase the hypotensive activities of Dorzolamide. Approved Dosulepin Furazolidone may increase the serotonergic activities of Dosulepin. Approved Doxapram Furazolidone may increase the hypertensive activities of Doxapram. Approved, Vet Approved Doxazosin Furazolidone may increase the hypotensive activities of Doxazosin. Approved Doxepin Furazolidone may increase the serotonergic activities of Doxepin. Approved Doxylamine Furazolidone may increase the anticholinergic activities of Doxylamine. Approved, Vet Approved Droxidopa The risk or severity of adverse effects can be increased when Furazolidone is combined with Droxidopa. Approved, Investigational Dulaglutide Furazolidone may increase the hypoglycemic activities of Dulaglutide. Approved Duloxetine Furazolidone may increase the serotonergic activities of Duloxetine. Approved Efonidipine Furazolidone may increase the hypotensive activities of Efonidipine. Approved Eletriptan The metabolism of Eletriptan can be decreased when combined with Furazolidone. Approved, Investigational Empagliflozin Furazolidone may increase the hypoglycemic activities of Empagliflozin. Approved Enalapril Furazolidone may increase the hypotensive activities of Enalapril. Approved, Vet Approved Enalaprilat Furazolidone may increase the hypotensive activities of Enalaprilat. Approved Entacapone The risk or severity of adverse effects can be increased when Entacapone is combined with Furazolidone. Approved, Investigational Ephedra The risk or severity of adverse effects can be increased when Furazolidone is combined with Ephedra. Approved, Nutraceutical, Withdrawn Epinephrine Furazolidone may increase the hypertensive activities of Epinephrine. Approved, Vet Approved Epoprostenol Furazolidone may increase the hypotensive activities of Epoprostenol. Approved Eprosartan Furazolidone may increase the hypotensive activities of Eprosartan. Approved Ergotamine Furazolidone may increase the hypertensive activities of Ergotamine. Approved Escitalopram Furazolidone may increase the serotonergic activities of Escitalopram. Approved, Investigational Esmirtazapine Furazolidone may increase the serotonergic activities of Esmirtazapine. Investigational Ethanol The risk or severity of adverse effects can be increased when Ethanol is combined with Furazolidone. Approved Etoperidone Furazolidone may increase the serotonergic activities of Etoperidone. Approved Exenatide Furazolidone may increase the hypoglycemic activities of Exenatide. Approved, Investigational Felodipine Furazolidone may increase the hypotensive activities of Felodipine. Approved, Investigational Fenfluramine The risk or severity of adverse effects can be increased when Furazolidone is combined with Fenfluramine. Illicit, Withdrawn Fenoldopam Furazolidone may increase the hypotensive activities of Fenoldopam. Approved Fenoterol The risk or severity of adverse effects can be increased when Furazolidone is combined with Fenoterol. Approved Fentanyl Fentanyl may increase the serotonergic activities of Furazolidone. Approved, Illicit, Investigational, Vet Approved Fluoxetine Furazolidone may increase the serotonergic activities of Fluoxetine. Approved, Vet Approved Fluvoxamine Furazolidone may increase the serotonergic activities of Fluvoxamine. Approved, Investigational Formoterol The risk or severity of adverse effects can be increased when Furazolidone is combined with Formoterol. Approved, Investigational Fosinopril Furazolidone may increase the hypotensive activities of Fosinopril. Approved Frovatriptan The metabolism of Frovatriptan can be decreased when combined with Furazolidone. Approved, Investigational Gliclazide Furazolidone may increase the hypoglycemic activities of Gliclazide. Approved Glimepiride Furazolidone may increase the hypoglycemic activities of Glimepiride. Approved Glipizide Furazolidone may increase the hypoglycemic activities of Glipizide. Approved Glyburide Furazolidone may increase the hypoglycemic activities of Glyburide. Approved Guanabenz Furazolidone may increase the hypotensive activities of Guanabenz. Approved Guanadrel Furazolidone may increase the hypotensive activities of Guanadrel. Approved Guanethidine Furazolidone may increase the hypotensive activities of Guanethidine. Approved Guanfacine Furazolidone may increase the hypotensive activities of Guanfacine. Approved, Investigational Hexamethonium Furazolidone may increase the hypotensive activities of Hexamethonium. Experimental Hydracarbazine Furazolidone may increase the hypertensive activities of Hydracarbazine. Experimental Hydralazine Furazolidone may increase the hypotensive activities of Hydralazine. Approved Hydrochlorothiazide Furazolidone may increase the hypotensive activities of Hydrochlorothiazide. Approved, Vet Approved Hydrocodone The risk or severity of adverse effects can be increased when Furazolidone is combined with Hydrocodone. Approved, Illicit Hydroflumethiazide Furazolidone may increase the hypotensive activities of Hydroflumethiazide. Approved Hydromorphone The risk or severity of adverse effects can be increased when Furazolidone is combined with Hydromorphone. Approved, Illicit Hydroxyamphetamine Furazolidone may increase the hypertensive activities of Hydroxyamphetamine hydrobromide. Approved Imidapril Furazolidone may increase the hypotensive activities of Imidapril. Investigational Imipramine Furazolidone may increase the serotonergic activities of Imipramine. Approved Indacaterol The risk or severity of adverse effects can be increased when Furazolidone is combined with Indacaterol. Approved Indalpine Furazolidone may increase the serotonergic activities of Indalpine. Investigational, Withdrawn Indapamide Furazolidone may increase the hypotensive activities of Indapamide. Approved Indenolol Furazolidone may increase the hypotensive activities of Indenolol. Withdrawn Indoramin Furazolidone may increase the hypotensive activities of Indoramin. Withdrawn Insulin Aspart Furazolidone may increase the hypoglycemic activities of Insulin Aspart. Approved Insulin Detemir Furazolidone may increase the hypoglycemic activities of Insulin Detemir. Approved Insulin Glargine Furazolidone may increase the hypoglycemic activities of Insulin Glargine. Approved Insulin Glulisine Furazolidone may increase the hypoglycemic activities of Insulin Glulisine. Approved Insulin Human Furazolidone may increase the hypoglycemic activities of Insulin Human. Approved, Investigational Insulin Lispro Furazolidone may increase the hypoglycemic activities of Insulin Lispro. Approved Iproclozide Furazolidone may increase the hypertensive activities of Iproclozide. Withdrawn Iproniazid Furazolidone may increase the hypertensive activities of Iproniazid. Withdrawn Irbesartan Furazolidone may increase the hypotensive activities of Irbesartan. Approved, Investigational Isocarboxazid Furazolidone may increase the hypertensive activities of Isocarboxazid. Approved Isoetarine The risk or severity of adverse effects can be increased when Furazolidone is combined with Isoetarine. Approved Isometheptene The risk or severity of adverse effects can be increased when Furazolidone is combined with Isometheptene. Approved Isoprenaline The risk or severity of adverse effects can be increased when Furazolidone is combined with Isoprenaline. Approved Isradipine Furazolidone may increase the hypotensive activities of Isradipine. Approved Ketanserin Furazolidone may increase the hypotensive activities of Ketanserin. Investigational L-Tryptophan The risk or severity of adverse effects can be increased when L-Tryptophan is combined with Furazolidone. Approved, Nutraceutical, Withdrawn Labetalol Furazolidone may increase the hypotensive activities of Labetalol. Approved Lacidipine Furazolidone may increase the hypotensive activities of Lacidipine. Approved Lanreotide Furazolidone may increase the hypoglycemic activities of Lanreotide. Approved Latanoprost Furazolidone may increase the hypotensive activities of Latanoprost. Approved, Investigational Lercanidipine Furazolidone may increase the hypotensive activities of Lercanidipine. Approved, Investigational Levodopa The risk or severity of adverse effects can be increased when Levodopa is combined with Furazolidone. Approved Levomilnacipran Furazolidone may increase the serotonergic activities of Levomilnacipran. Approved Levonordefrin Furazolidone may increase the hypertensive activities of Levonordefrin. Approved Linezolid The risk or severity of adverse effects can be increased when Furazolidone is combined with Linezolid. Approved, Investigational Liraglutide Furazolidone may increase the hypoglycemic activities of Liraglutide. Approved Lisdexamfetamine Furazolidone may increase the hypertensive activities of Lisdexamfetamine. Approved, Investigational Lisinopril Furazolidone may increase the hypotensive activities of Lisinopril. Approved, Investigational Lisuride The metabolism of Lisuride can be decreased when combined with Furazolidone. Approved Lithium The risk or severity of adverse effects can be increased when Furazolidone is combined with Lithium. Approved Lofexidine Furazolidone may increase the hypotensive activities of Lofexidine. Approved, Investigational Losartan Furazolidone may increase the hypotensive activities of Losartan. Approved Macitentan Furazolidone may increase the hypotensive activities of Macitentan. Approved Manidipine Furazolidone may increase the hypotensive activities of Manidipine. Approved Maprotiline The risk or severity of adverse effects can be increased when Maprotiline is combined with Furazolidone. Approved Mebanazine Furazolidone may increase the hypertensive activities of Mebanazine. Withdrawn Mecamylamine Furazolidone may increase the hypotensive activities of Mecamylamine. Approved Mecasermin Furazolidone may increase the hypoglycemic activities of Mecasermin. Approved, Investigational Mephedrone Furazolidone may increase the hypertensive activities of Mephedrone. Investigational Mephentermine Furazolidone may increase the hypertensive activities of Mephentermine. Approved Mequitazine Furazolidone may increase the anticholinergic activities of Mequitazine. Approved Metaraminol Furazolidone may increase the hypertensive activities of Metaraminol. Approved, Investigational Metformin Furazolidone may increase the hypoglycemic activities of Metformin. Approved Methadone The risk or severity of adverse effects can be increased when Furazolidone is combined with Methadone. Approved Methamphetamine Furazolidone may increase the hypertensive activities of Methamphetamine. Approved, Illicit Methoxamine Furazolidone may increase the hypertensive activities of Methoxamine. Approved Methyldopa The risk or severity of adverse effects can be increased when Furazolidone is combined with Methyldopa. Approved Methylene blue Furazolidone may increase the serotonergic activities of Methylene blue. Investigational Methylphenidate Furazolidone may increase the hypertensive activities of Methylphenidate. Approved, Investigational Metipranolol Furazolidone may increase the hypotensive activities of Metipranolol. Approved Metolazone Furazolidone may increase the hypotensive activities of Metolazone. Approved Metoprolol Furazolidone may increase the hypotensive activities of Metoprolol. Approved, Investigational Metyrosine Furazolidone may increase the hypotensive activities of Metyrosine. Approved Mianserin Furazolidone may increase the neurotoxic activities of Mianserin. Approved Mibefradil Furazolidone may increase the hypotensive activities of Mibefradil. Withdrawn Midodrine Furazolidone may increase the hypertensive activities of Midodrine. Approved Mifepristone Furazolidone may increase the hypoglycemic activities of Mifepristone. Approved, Investigational Miglitol Furazolidone may increase the hypoglycemic activities of Miglitol. Approved Milnacipran Furazolidone may increase the serotonergic activities of Milnacipran. Approved Minaprine Furazolidone may increase the hypertensive activities of Minaprine. Approved Minoxidil Furazolidone may increase the hypotensive activities of Minoxidil. Approved Mirtazapine Furazolidone may increase the central neurotoxic activities of Mirtazapine. Approved MMDA Furazolidone may increase the hypertensive activities of MMDA. Experimental, Illicit Moclobemide The risk or severity of adverse effects can be increased when Furazolidone is combined with Moclobemide. Approved Moexipril Furazolidone may increase the hypotensive activities of Moexipril. Approved Morphine The risk or severity of adverse effects can be increased when Furazolidone is combined with Morphine. Approved, Investigational Moxonidine Furazolidone may increase the hypotensive activities of Moxonidine. Approved Nadolol Furazolidone may increase the hypotensive activities of Nadolol. Approved Naftopidil Furazolidone may increase the hypotensive activities of Naftopidil. Investigational Naratriptan The metabolism of Naratriptan can be decreased when combined with Furazolidone. Approved, Investigational Nateglinide Furazolidone may increase the hypoglycemic activities of Nateglinide. Approved, Investigational Nebivolol Furazolidone may increase the hypotensive activities of Nebivolol. Approved, Investigational Nefazodone Furazolidone may increase the serotonergic activities of Nefazodone. Approved, Withdrawn Nialamide Furazolidone may increase the hypertensive activities of Nialamide. Withdrawn Nicardipine Furazolidone may increase the hypotensive activities of Nicardipine. Approved Nicorandil Furazolidone may increase the hypotensive activities of Nicorandil. Approved Niguldipine Furazolidone may increase the hypotensive activities of Niguldipine. Experimental Nilvadipine Furazolidone may increase the hypotensive activities of Nilvadipine. Approved Nimodipine Furazolidone may increase the hypotensive activities of Nimodipine. Approved Nisoldipine Furazolidone may increase the hypotensive activities of Nisoldipine. Approved Nitrendipine Furazolidone may increase the hypotensive activities of Nitrendipine. Approved Nitroprusside Furazolidone may increase the hypotensive activities of Nitroprusside. Approved Norepinephrine Furazolidone may increase the hypertensive activities of Norepinephrine. Approved Nortriptyline Furazolidone may increase the serotonergic activities of Nortriptyline. Approved Octamoxin Furazolidone may increase the hypertensive activities of Octamoxin. Withdrawn Octreotide Furazolidone may increase the hypoglycemic activities of Octreotide. Approved, Investigational Olanzapine The risk or severity of adverse effects can be increased when Furazolidone is combined with Olanzapine. Approved, Investigational Olmesartan Furazolidone may increase the hypotensive activities of Olmesartan. Approved, Investigational Olodaterol The risk or severity of adverse effects can be increased when Furazolidone is combined with Olodaterol. Approved Omapatrilat Furazolidone may increase the hypotensive activities of Omapatrilat. Investigational Opipramol Furazolidone may increase the serotonergic activities of Opipramol. Investigational Orciprenaline The risk or severity of adverse effects can be increased when Furazolidone is combined with Orciprenaline. Approved Oxprenolol Furazolidone may increase the hypotensive activities of Oxprenolol. Approved Oxycodone The risk or severity of adverse effects can be increased when Furazolidone is combined with Oxycodone. Approved, Illicit, Investigational Oxymorphone The risk or severity of adverse effects can be increased when Oxymorphone is combined with Furazolidone. Approved, Investigational, Vet Approved Pargyline Furazolidone may increase the hypertensive activities of Pargyline. Approved Paroxetine Furazolidone may increase the serotonergic activities of Paroxetine. Approved, Investigational Pasireotide Furazolidone may increase the hypoglycemic activities of Pasireotide. Approved Penbutolol Furazolidone may increase the hypotensive activities of Penbutolol. Approved, Investigational Pentamidine Furazolidone may increase the hypoglycemic activities of Pentamidine. Approved Pentolinium Furazolidone may increase the hypotensive activities of Pentolinium. Approved Pergolide The metabolism of Pergolide can be decreased when combined with Furazolidone. Approved, Vet Approved, Withdrawn Perindopril Furazolidone may increase the hypotensive activities of Perindopril. Approved Pethidine Furazolidone may increase the serotonergic activities of Pethidine. Approved Phenelzine Furazolidone may increase the hypertensive activities of Phenelzine. Approved Pheniprazine Furazolidone may increase the hypertensive activities of Pheniprazine. Withdrawn Phenoxybenzamine Furazolidone may increase the hypotensive activities of Phenoxybenzamine. Approved Phenoxypropazine Furazolidone may increase the hypertensive activities of Phenoxypropazine. Withdrawn Phentermine Furazolidone may increase the hypertensive activities of Phentermine. Approved, Illicit Phentolamine Furazolidone may increase the hypotensive activities of Phentolamine. Approved Phenylephrine Furazolidone may increase the hypertensive activities of Phenylephrine. Approved Phenylpropanolamine The risk or severity of adverse effects can be increased when Furazolidone is combined with Phenylpropanolamine. Approved, Vet Approved, Withdrawn Pholcodine Pholcodine may increase the serotonergic activities of Furazolidone. Approved, Illicit Pinacidil Furazolidone may increase the hypotensive activities of Pinacidil. Withdrawn Pindolol Furazolidone may increase the hypotensive activities of Pindolol. Approved Pioglitazone Furazolidone may increase the hypoglycemic activities of Pioglitazone. Approved, Investigational Pirbuterol The risk or severity of adverse effects can be increased when Furazolidone is combined with Pirbuterol. Approved Pirlindole Furazolidone may increase the hypertensive activities of Pirlindole. Approved Pivhydrazine Furazolidone may increase the hypertensive activities of Pivhydrazine. Withdrawn Pizotifen Furazolidone may increase the anticholinergic activities of Pizotifen. Approved Polythiazide Furazolidone may increase the hypotensive activities of Polythiazide. Approved Pramlintide Furazolidone may increase the hypoglycemic activities of Pramlintide. Approved, Investigational Prazosin Furazolidone may increase the hypotensive activities of Prazosin. Approved Procaterol The risk or severity of adverse effects can be increased when Furazolidone is combined with Procaterol. Approved Propranolol Furazolidone may increase the hypotensive activities of Propranolol. Approved, Investigational Protriptyline Furazolidone may increase the serotonergic activities of Protriptyline. Approved PRX-00023 The metabolism of PRX-00023 can be decreased when combined with Furazolidone. Investigational Pseudoephedrine Furazolidone may increase the hypertensive activities of Pseudoephedrine. Approved Quinapril Furazolidone may increase the hypotensive activities of Quinapril. Approved, Investigational Quinine Furazolidone may increase the hypoglycemic activities of Quinine. Approved Ramipril Furazolidone may increase the hypotensive activities of Ramipril. Approved Rasagiline Furazolidone may increase the hypertensive activities of Rasagiline. Approved Remifentanil Remifentanil may increase the serotonergic activities of Furazolidone. Approved Remikiren Furazolidone may increase the hypotensive activities of Remikiren. Approved Repaglinide Furazolidone may increase the hypoglycemic activities of Repaglinide. Approved, Investigational Rescinnamine Furazolidone may increase the hypotensive activities of Rescinnamine. Approved Reserpine The risk or severity of adverse effects can be increased when Furazolidone is combined with Reserpine. Approved Rilmenidine Furazolidone may increase the hypotensive activities of Rilmenidine. Investigational Riociguat Furazolidone may increase the hypotensive activities of Riociguat. Approved Ritobegron Furazolidone may increase the hypertensive activities of Ritobegron. Investigational Ritodrine The risk or severity of adverse effects can be increased when Furazolidone is combined with Ritodrine. Approved Rizatriptan The metabolism of Rizatriptan can be decreased when combined with Furazolidone. Approved Ropinirole The metabolism of Ropinirole can be decreased when combined with Furazolidone. Approved, Investigational Rosiglitazone Furazolidone may increase the hypoglycemic activities of Rosiglitazone. Approved, Investigational Safrazine Furazolidone may increase the hypertensive activities of Safrazine. Withdrawn Salbutamol The risk or severity of adverse effects can be increased when Furazolidone is combined with Salbutamol. Approved, Vet Approved Salmeterol The risk or severity of adverse effects can be increased when Furazolidone is combined with Salmeterol. Approved Saprisartan Furazolidone may increase the hypotensive activities of Saprisartan. Experimental Saxagliptin Furazolidone may increase the hypoglycemic activities of Saxagliptin. Approved Selegiline Furazolidone may increase the hypertensive activities of Selegiline. Approved, Investigational, Vet Approved Selexipag Furazolidone may increase the hypotensive activities of Selexipag. Approved Sertraline Furazolidone may increase the serotonergic activities of Sertraline. Approved Sitagliptin Furazolidone may increase the hypoglycemic activities of Sitagliptin. Approved, Investigational Sitaxentan Furazolidone may increase the hypotensive activities of Sitaxentan. Approved, Investigational, Withdrawn Spirapril Furazolidone may increase the hypotensive activities of Spirapril. Approved Sufentanil Sufentanil may increase the serotonergic activities of Furazolidone. Approved, Investigational Sulfadiazine Furazolidone may increase the hypoglycemic activities of Sulfadiazine. Approved, Vet Approved Sulfamethoxazole Furazolidone may increase the hypoglycemic activities of Sulfamethoxazole. Approved Sulfisoxazole Furazolidone may increase the hypoglycemic activities of Sulfisoxazole. Approved, Vet Approved Sumatriptan The metabolism of Sumatriptan can be decreased when combined with Furazolidone. Approved, Investigational Sunitinib Furazolidone may increase the hypoglycemic activities of Sunitinib. Approved, Investigational Tapentadol The risk or severity of adverse effects can be increased when Tapentadol is combined with Furazolidone. Approved Telmisartan Furazolidone may increase the hypotensive activities of Telmisartan. Approved, Investigational Temocapril Furazolidone may increase the hypotensive activities of Temocapril. Experimental, Investigational Terbutaline The risk or severity of adverse effects can be increased when Furazolidone is combined with Terbutaline. Approved Terlipressin Furazolidone may increase the hypotensive activities of Terlipressin. Approved, Investigational Testosterone Propionate The risk or severity of adverse effects can be increased when Testosterone Propionate is combined with Furazolidone. Approved, Vet Approved Tetrabenazine The risk or severity of adverse effects can be increased when Tetrabenazine is combined with Furazolidone. Approved Tetryzoline Furazolidone may increase the hypertensive activities of Tetryzoline. Approved Tianeptine The risk or severity of adverse effects can be increased when Tianeptine is combined with Furazolidone. Approved Tibolone Furazolidone may increase the hypotensive activities of Tibolone. Approved Ticrynafen Furazolidone may increase the hypotensive activities of Ticrynafen. Withdrawn Timolol Furazolidone may increase the hypotensive activities of Timolol. Approved Tolazamide Furazolidone may increase the hypoglycemic activities of Tolazamide. Approved Tolazoline Furazolidone may increase the hypotensive activities of Tolazoline. Approved, Vet Approved Tolbutamide Furazolidone may increase the hypoglycemic activities of Tolbutamide. Approved Tolcapone The risk or severity of adverse effects can be increased when Tolcapone is combined with Furazolidone. Approved, Withdrawn Toloxatone Furazolidone may increase the hypertensive activities of Toloxatone. Approved Torasemide Furazolidone may increase the hypotensive activities of Torasemide. Approved Tramadol Tramadol may increase the neuroexcitatory activities of Furazolidone. Approved, Investigational Trandolapril Furazolidone may increase the hypotensive activities of Trandolapril. Approved Trans-2-Phenylcyclopropylamine Furazolidone may increase the hypertensive activities of Trans-2-Phenylcyclopropylamine. Experimental Tranylcypromine Furazolidone may increase the hypertensive activities of Tranylcypromine. Approved Travoprost Furazolidone may increase the hypotensive activities of Travoprost. Approved Trazodone The risk or severity of adverse effects can be increased when Furazolidone is combined with Trazodone. Approved, Investigational Treprostinil Furazolidone may increase the hypotensive activities of Treprostinil. Approved, Investigational Trichlormethiazide Furazolidone may increase the hypotensive activities of Trichlormethiazide. Approved, Vet Approved Trimazosin Furazolidone may increase the hypotensive activities of Trimazosin. Experimental Trimethaphan Furazolidone may increase the hypotensive activities of Trimethaphan. Approved Trimipramine Furazolidone may increase the serotonergic activities of Trimipramine. Approved Unoprostone Furazolidone may increase the hypotensive activities of Unoprostone. Approved Valsartan Furazolidone may increase the hypotensive activities of Valsartan. Approved, Investigational Venlafaxine Furazolidone may increase the serotonergic activities of Venlafaxine. Approved Vilanterol The risk or severity of adverse effects can be increased when Furazolidone is combined with Vilanterol. Approved Vilazodone The metabolism of Vilazodone can be decreased when combined with Furazolidone. Approved Vinpocetine Furazolidone may increase the hypotensive activities of Vinpocetine. Investigational Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Furazolidone. Approved Xylometazoline Furazolidone may increase the hypotensive activities of Xylometazoline. Approved Zimelidine Furazolidone may increase the serotonergic activities of Zimelidine. Withdrawn Zolmitriptan The metabolism of Zolmitriptan can be decreased when combined with Furazolidone. Approved, Investigational - Food Interactions
- Not Available
References
- Synthesis Reference
Drake, G.D., Gever, G. and Hayes, K.J.; U.S. Patent 2,759,931; August 21, 1956; assigned to The Norwich Pharmacal Company. Gever, G. and O'Keefe, C.J.; U.S. Patent 2,927,l IO; March 1, 1960; assigned to The Norwich Pharmacal Company.
US2742462- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB14752
- KEGG Drug
- D00830
- KEGG Compound
- C07999
- PubChem Compound
- 3435
- PubChem Substance
- 46507291
- ChemSpider
- 4481255
- ChEBI
- 5195
- ChEMBL
- CHEMBL1103
- Therapeutic Targets Database
- DAP000993
- PharmGKB
- PA164746760
- RxList
- RxList Drug Page
- Drugs.com
- Drugs.com Drug Page
- Wikipedia
- Furazolidone
- ATC Codes
- G01AX06 — Furazolidone
- AHFS Codes
- Not Available
- PDB Entries
- Not Available
- FDA label
- Not Available
- MSDS
- Download (74.1 KB)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Treatment Functional Dyspepsia / Scarred Peptic Ulcer 1 4 Not Yet Recruiting Treatment Antimicrobial Susceptibility Testing / Triple Therapy 1 4 Recruiting Treatment Antimicrobial Susceptibility Testing / Bacterial Infection Due to Helicobacter Pylori (H. Pylori) 1 4 Recruiting Treatment Bacterial Infection Due to Helicobacter Pylori (H. Pylori) 1 Not Available Completed Treatment Treatment of Helicobacter Pylori 1
Pharmacoeconomics
- Manufacturers
- Shire development inc
- Packagers
- Professional Co.
- Dosage forms
- Not Available
- Prices
Unit description Cost Unit Furazolidone powder 2.04USD g DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 254-256 Drake, G.D., Gever, G. and Hayes, K.J.; U.S. Patent 2,759,931; August 21, 1956; assigned to The Norwich Pharmacal Company. Gever, G. and O'Keefe, C.J.; U.S. Patent 2,927,l IO; March 1, 1960; assigned to The Norwich Pharmacal Company water solubility 40 mg/L (at 25 °C) MERCK INDEX (1996); pH 6 logP -0.04 DEBNATH,AK ET AL. (1991) - Predicted Properties
Property Value Source Water Solubility 0.364 mg/mL ALOGPS logP 0.15 ALOGPS logP 0.87 ChemAxon logS -2.8 ALOGPS pKa (Strongest Basic) -2.4 ChemAxon Physiological Charge 0 ChemAxon Hydrogen Acceptor Count 4 ChemAxon Hydrogen Donor Count 0 ChemAxon Polar Surface Area 100.86 Å2 ChemAxon Rotatable Bond Count 3 ChemAxon Refractivity 51.09 m3·mol-1 ChemAxon Polarizability 19.74 Å3 ChemAxon Number of Rings 2 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter Yes ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET features
Property Value Probability Human Intestinal Absorption + 0.9038 Blood Brain Barrier + 0.9117 Caco-2 permeable - 0.5736 P-glycoprotein substrate Non-substrate 0.7829 P-glycoprotein inhibitor I Non-inhibitor 0.7761 P-glycoprotein inhibitor II Non-inhibitor 0.9597 Renal organic cation transporter Non-inhibitor 0.8351 CYP450 2C9 substrate Non-substrate 0.8117 CYP450 2D6 substrate Non-substrate 0.8415 CYP450 3A4 substrate Substrate 0.5984 CYP450 1A2 substrate Inhibitor 0.9107 CYP450 2C9 inhibitor Non-inhibitor 0.907 CYP450 2D6 inhibitor Non-inhibitor 0.9134 CYP450 2C19 inhibitor Non-inhibitor 0.9026 CYP450 3A4 inhibitor Non-inhibitor 0.928 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.8828 Ames test AMES toxic 0.9108 Carcinogenicity Non-carcinogens 0.9097 Biodegradation Ready biodegradable 0.8978 Rat acute toxicity 2.1639 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.7889 hERG inhibition (predictor II) Non-inhibitor 0.9057
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available Predicted LC-MS/MS Spectrum - 10V, Positive Predicted LC-MS/MS Not Available Predicted LC-MS/MS Spectrum - 20V, Positive Predicted LC-MS/MS Not Available Predicted LC-MS/MS Spectrum - 40V, Positive Predicted LC-MS/MS Not Available Predicted LC-MS/MS Spectrum - 10V, Negative Predicted LC-MS/MS Not Available Predicted LC-MS/MS Spectrum - 20V, Negative Predicted LC-MS/MS Not Available Predicted LC-MS/MS Spectrum - 40V, Negative Predicted LC-MS/MS Not Available
Taxonomy
- Description
- This compound belongs to the class of chemical entities known as nitrofurans. These are compounds containing a furan ring which bears a nitro group.
- Kingdom
- Chemical entities
- Super Class
- Organic compounds
- Class
- Organoheterocyclic compounds
- Sub Class
- Furans
- Direct Parent
- Nitrofurans
- Alternative Parents
- Nitroaromatic compounds / Oxazolidinones / Heteroaromatic compounds / Propargyl-type 1,3-dipolar organic compounds / Oxacyclic compounds / Organic oxoazanium compounds / Azacyclic compounds / Organopnictogen compounds / Organonitrogen compounds / Organic oxides show 2 more
- Substituents
- Nitroaromatic compound / 2-nitrofuran / Oxazolidinone / Oxazolidine / Heteroaromatic compound / C-nitro compound / Organic nitro compound / Organic oxoazanium / Oxacycle / Azacycle show 12 more
- Molecular Framework
- Aromatic heteromonocyclic compounds
- External Descriptors
- oxazolidines, nitrofuran antibiotic (CHEBI:5195 )
Targets
1. DNA
Yes
Cross-linking/alkylation
- General Function:
- Used for biological information storage.
- Specific Function:
- DNA contains the instructions needed for an organism to develop, survive and reproduce.
- Molecular Weight:
- 2.15 x 1012 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
- Meng J, Mangat SS, Grudzinski IP, Law FC: Evidence of 14C-furazolidone metabolite binding to the hepatic DNA of trout. Drug Metabol Drug Interact. 1998;14(4):209-19. [PubMed:10694929 ]
Enzymes
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Primary amine oxidase activity
- Specific Function
- Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral...
- Gene Name
- MAOB
- Uniprot ID
- P27338
- Uniprot Name
- Amine oxidase [flavin-containing] B
- Molecular Weight
- 58762.475 Da
References
- Timperio AM, Kuiper HA, Zolla L: Identification of a furazolidone metabolite responsible for the inhibition of amino oxidases. Xenobiotica. 2003 Feb;33(2):153-67. [PubMed:12623758 ]
- Ali BH: Pharmacological, therapeutic and toxicological properties of furazolidone: some recent research. Vet Res Commun. 1999 Oct;23(6):343-60. [PubMed:10543364 ]
- Hoogenboom LA, Tomassini O, Oorsprong MB, Kuiper HA: Use of pig hepatocytes to study the inhibition of monoamine oxidase by furazolidone. Food Chem Toxicol. 1991 Mar;29(3):185-91. [PubMed:2032659 ]
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Serotonin binding
- Specific Function
- Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral...
- Gene Name
- MAOA
- Uniprot ID
- P21397
- Uniprot Name
- Amine oxidase [flavin-containing] A
- Molecular Weight
- 59681.27 Da
References
- Timperio AM, Kuiper HA, Zolla L: Identification of a furazolidone metabolite responsible for the inhibition of amino oxidases. Xenobiotica. 2003 Feb;33(2):153-67. [PubMed:12623758 ]
- Ali BH: Pharmacological, therapeutic and toxicological properties of furazolidone: some recent research. Vet Res Commun. 1999 Oct;23(6):343-60. [PubMed:10543364 ]
- Hoogenboom LA, Tomassini O, Oorsprong MB, Kuiper HA: Use of pig hepatocytes to study the inhibition of monoamine oxidase by furazolidone. Food Chem Toxicol. 1991 Mar;29(3):185-91. [PubMed:2032659 ]
Drug created on June 13, 2005 07:24 / Updated on September 01, 2017 10:29