Pituitary Hormones

Hormones secreted by the PITUITARY GLAND including those from the anterior lobe (adenohypophysis), the posterior lobe (neurohypophysis), and the ill-defined intermediate lobe. Structurally, they include small peptides, proteins, and glycoproteins. They are under the regulation of neural signals (NEUROTRANSMITTERS) or neuroendocrine signals (HYPOTHALAMIC HORMONES) from the hypothalamus as well as feedback from their targets such as ADRENAL CORTEX HORMONES; ANDROGENS; ESTROGENS.
DrugDrug NameDrug Description
DB00024Thyrotropin alfaA recombinant form of thyroid stimulating hormone used in diagnostic testing for thyroid cancer and alongside radioactive agents to destroy thyroid tissue.
DB00032MenotropinsA purified combination of human luteinizing hormone and follicle stimulating hormone used to treat female infertility.
DB00035DesmopressinA synthetic analog of vasopressin used to reduce renal excretion of water in central diabetes insipidus and nocturia.
DB00052SomatotropinA form of recombinant human growth hormone used to treat dwarfism, growth hormone deficiency, and acromegaly as well as to prevent weight loss in HIV patients.
DB00066FollitropinA form of recombinant human follicle stimulating hormone used to stimulate follicle development in women with primary ovarian hypogonadism and in men with hypogonadotropic hypogonadism.
DB00067VasopressinA peptide hormone used to increase blood pressure in patients with vasodilatory shock who are resistant to fluid and catecholamine therapy.
DB00082PegvisomantA growth hormone receptor antagonist used to treat acromegaly.
DB00093FelypressinFor use as an alternative to adrenaline as a localising agent, provided that local ischaemia is not essential.
DB00094UrofollitropinA form of purified human follicle stimulating hormone used to treat infertility in females by inducing follicle development in women without primary ovarian failure.
DB00107OxytocinA recombinant hormone used to induce or strengthen uterine contractions in pregnant women to aid in labor and delivery or to control postpartum bleeding.
DB01282CarbetocinAn oxytocin agent used to control postpartum hemorrhage and bleeding after giving birth.
DB01284TetracosactideA diagnostic agent used in the screening of patients presumed to have adrenocortical insufficiency.
DB01285CorticotropinA diagnostic agent used in the screening of patients presumed to have adrenocortical insufficiency.
DB02638TerlipressinCommonly used to stop bleeding of varices in the food pipe (oesophagus).
DB09059AtosibanAn inhibitor of oxytocin and vasopressin used to delay imminent preterm birth in pregnant adult women displaying specific clinical observations.
DB09066Corifollitropin alfaA FSH analogue indicated for Controlled Ovarian Stimulation (COS) in combination with a GnRH antagonist for the development of multiple follicles in women participating in an Assisted Reproductive Technology (ART) program.
DB09098SomatremA recombinant growth hormone used to treat adult growth hormone deficiency and treat disrupted growth in children due to growth hormone insufficiency or deficiency, turner's syndrome, chronic renal failure, and small stature for gestational age.
DB11653BremelanotideBremelanotide is indicated to treat premenopausal women with hypoactive sexual desire disorder that is not due to a medical or psychiatric condition, problems with the relationship, or the effects of...
DB11700SetmelanotideSetmelanotide has been investigated for the treatment of obesity.
DB12495SelepressinSelepressin has been used in trials studying the treatment of Septic Shock.
DB13298AlsactideNot Annotated
DB13464OrnipressinNot Annotated
DB13798DemoxytocinNot Annotated
DB14642LypressinNot Annotated
DB14741Luteinizing hormoneNot Annotated
DB15093SomapacitanSomapacitan is under investigation in clinical trial NCT01706783 (A Trial Investigating the Safety, Tolerability, Availability and Distribution in the Body of Once-weekly Long-acting Growth Hormone (Somapacitan) Compared to Once Daily...
DB15112Somatropin pegolSomatropin pegol is under investigation in clinical trial NCT00715689 (Dose Study in Growth Hormone Deficient Adults Investigating Safety, Pharmacokinetics and Pharmacodynamics of NNC126-0083).
DB15263ThyrotropinThyrotropin is under investigation in clinical trial NCT01348191 (Detection of Thyrotrophin Receptor in Human Myometrium).
DB12950AlbusomatropinAlbusomatropin has been used in trials studying the treatment of Growth Hormone-Deficiency and Growth Hormone Deficiency.
DrugDrug NameTargetType
DB00024Thyrotropin alfaThyrotropin receptortarget
DB00032MenotropinsFollicle-stimulating hormone receptortarget
DB00032MenotropinsLutropin-choriogonadotropic hormone receptortarget
DB00035DesmopressinVasopressin V1a receptortarget
DB00035DesmopressinVasopressin V1b receptortarget
DB00035DesmopressinVasopressin V2 receptortarget
DB00035DesmopressinProstaglandin G/H synthase 1enzyme
DB00035DesmopressinProstaglandin G/H synthase 2enzyme
DB00052SomatotropinGrowth hormone receptortarget
DB00052SomatotropinProlactin receptortarget
DB00066FollitropinFollicle-stimulating hormone receptortarget
DB00067VasopressinVasopressin V1a receptortarget
DB00067VasopressinVasopressin V2 receptortarget
DB00067VasopressinVasopressin V1b receptortarget
DB00067VasopressinCanalicular multispecific organic anion transporter 1transporter
DB00082PegvisomantGrowth hormone receptortarget
DB00082PegvisomantSterol 26-hydroxylase, mitochondrialenzyme
DB00082PegvisomantGlutamine synthetaseenzyme
DB00082PegvisomantCytochrome P450 2C18enzyme
DB00082PegvisomantCytochrome P450 3A4enzyme
DB00082PegvisomantCholinesteraseenzyme
DB00082PegvisomantCytochrome P450 4A11enzyme
DB00093FelypressinVasopressin V1a receptortarget
DB00094UrofollitropinFollicle-stimulating hormone receptortarget
DB00107OxytocinOxytocin-neurophysin 1target
DB00107OxytocinOxytocin receptortarget
DB00107OxytocinProlyl endopeptidaseenzyme
DB01282CarbetocinOxytocin receptortarget
DB01284TetracosactideAdrenocorticotropic hormone receptortarget
DB01285CorticotropinAdrenocorticotropic hormone receptortarget
DB01285CorticotropinCorticoliberintarget
DB01285Corticotropin3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme
DB01285Corticotropin25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialenzyme
DB01285Corticotropin1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
DB01285CorticotropinCytochrome P450 3A4enzyme
DB02638TerlipressinVasopressin V1a receptortarget
DB02638TerlipressinVasopressin V2 receptortarget
DB02638TerlipressinVasopressin V1b receptortarget
DB09059AtosibanOxytocin receptortarget
DB09059AtosibanVasopressin V1a receptortarget
DB09059AtosibanVasopressin V1b receptortarget
DB09059AtosibanVasopressin V2 receptortarget
DB09066Corifollitropin alfaFollicle-stimulating hormone receptortarget
DB09098SomatremGrowth hormone receptortarget
DB09098SomatremInsulin-like growth factor 1 receptortarget
DB11653BremelanotideMelanocyte-stimulating hormone receptortarget
DB11653BremelanotideMelanocortin receptor 4target
DB11653BremelanotideMelanocortin receptor 3target
DB11653BremelanotideMelanocortin receptor 5target
DB11653BremelanotideAdrenocorticotropic hormone receptortarget
DB14642LypressinVasopressin V1a receptortarget
DB14642LypressinVasopressin V2 receptortarget
DB14642LypressinVasopressin V1b receptortarget
DB14642LypressinCanalicular multispecific organic anion transporter 1transporter