Pituitary Hormones

Name
Pituitary Hormones
Accession Number
DBCAT000096
Description

Hormones secreted by the PITUITARY GLAND including those from the anterior lobe (adenohypophysis), the posterior lobe (neurohypophysis), and the ill-defined intermediate lobe. Structurally, they include small peptides, proteins, and glycoproteins. They are under the regulation of neural signals (NEUROTRANSMITTERS) or neuroendocrine signals (HYPOTHALAMIC HORMONES) from the hypothalamus as well as feedback from their targets such as ADRENAL CORTEX HORMONES; ANDROGENS; ESTROGENS.

Drugs
DrugDrug Description
Thyrotropin alfaA recombinant form of thyroid stimulating hormone used in diagnostic testing for thyroid cancer and alongside radioactive agents to destroy thyroid tissue.
MenotropinsA purified combination of human luteinizing hormone and follicle stimulating hormone used to treat female infertility.
DesmopressinA synthetic analog of vasopressin used to reduce renal excretion of water in central diabetes insipidus and nocturia.
SomatotropinA form of recombinant human growth hormone used to treat dwarfism, growth hormone deficiency, and acromegaly as well as to prevent weight loss in HIV patients.
FollitropinA form of recombinant human follicle stimulating hormone used to stimulate follicle development in women with primary ovarian hypogonadism and in men with hypogonadotropic hypogonadism.
VasopressinA peptide hormone used to increase blood pressure in patients with vasodilatory shock who are resistant to fluid and catecholamine therapy.
PegvisomantA growth hormone receptor antagonist used to treat acromegaly.
FelypressinFor use as an alternative to adrenaline as a localising agent, provided that local ischaemia is not essential.
UrofollitropinA form of purified human follicle stimulating hormone used to treat infertility in females by inducing follicle development in women without primary ovarian failure.
OxytocinA recombinant hormone used to induce or strengthen uterine contractions in pregnant women to aid in labor and delivery or to control postpartum bleeding.
CarbetocinAn oxytocin agent used to control postpartum hemorrhage and bleeding after giving birth.
TetracosactideA diagnostic agent used in the screening of patients presumed to have adrenocortical insufficiency.
CorticotropinA diagnostic agent used in the screening of patients presumed to have adrenocortical insufficiency.
TerlipressinCommonly used to stop bleeding of varices in the food pipe (oesophagus).
AtosibanAn inhibitor of oxytocin and vasopressin used to delay imminent preterm birth in pregnant adult women displaying specific clinical observations.
Corifollitropin alfaA FSH analogue indicated for Controlled Ovarian Stimulation (COS) in combination with a GnRH antagonist for the development of multiple follicles in women participating in an Assisted Reproductive Technology (ART) program.
SomatremA recombinant growth hormone used to treat adult growth hormone deficiency and treat disrupted growth in children due to growth hormone insufficiency or deficiency, turner's syndrome, chronic renal failure, and small stature for gestational age.
BremelanotideBremelanotide is indicated to treat premenopausal women with hypoactive sexual desire disorder that is not due to a medical or psychiatric condition, problems with the relationship, or the effects of...
SetmelanotideSetmelanotide has been investigated for the treatment of obesity.
SelepressinSelepressin has been used in trials studying the treatment of Septic Shock.
AlsactideNot Annotated
OrnipressinNot Annotated
DemoxytocinNot Annotated
LypressinNot Annotated
Luteinizing hormoneNot Annotated
SomapacitanSomapacitan is under investigation in clinical trial NCT01706783 (A Trial Investigating the Safety, Tolerability, Availability and Distribution in the Body of Once-weekly Long-acting Growth Hormone (Somapacitan) Compared to Once Daily...
Somatropin pegolSomatropin pegol is under investigation in clinical trial NCT00715689 (Dose Study in Growth Hormone Deficient Adults Investigating Safety, Pharmacokinetics and Pharmacodynamics of NNC126-0083).
ThyrotropinThyrotropin is under investigation in clinical trial NCT01348191 (Detection of Thyrotrophin Receptor in Human Myometrium).
AlbusomatropinAlbusomatropin has been used in trials studying the treatment of Growth Hormone-Deficiency and Growth Hormone Deficiency.
Drugs & Drug Targets
DrugTargetType
Thyrotropin alfaThyrotropin receptortarget
MenotropinsFollicle-stimulating hormone receptortarget
MenotropinsLutropin-choriogonadotropic hormone receptortarget
DesmopressinVasopressin V1a receptortarget
DesmopressinVasopressin V1b receptortarget
DesmopressinVasopressin V2 receptortarget
DesmopressinProstaglandin G/H synthase 1enzyme
DesmopressinProstaglandin G/H synthase 2enzyme
SomatotropinGrowth hormone receptortarget
SomatotropinProlactin receptortarget
FollitropinFollicle-stimulating hormone receptortarget
VasopressinVasopressin V1a receptortarget
VasopressinVasopressin V2 receptortarget
VasopressinVasopressin V1b receptortarget
VasopressinCanalicular multispecific organic anion transporter 1transporter
PegvisomantGrowth hormone receptortarget
PegvisomantSterol 26-hydroxylase, mitochondrialenzyme
PegvisomantGlutamine synthetaseenzyme
PegvisomantCytochrome P450 2C18enzyme
PegvisomantCytochrome P450 3A4enzyme
PegvisomantCholinesteraseenzyme
PegvisomantCytochrome P450 4A11enzyme
FelypressinVasopressin V1a receptortarget
UrofollitropinFollicle-stimulating hormone receptortarget
OxytocinOxytocin-neurophysin 1target
OxytocinOxytocin receptortarget
OxytocinProlyl endopeptidaseenzyme
CarbetocinOxytocin receptortarget
TetracosactideAdrenocorticotropic hormone receptortarget
CorticotropinAdrenocorticotropic hormone receptortarget
CorticotropinCorticoliberintarget
Corticotropin3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme
Corticotropin25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialenzyme
Corticotropin1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
CorticotropinCytochrome P450 3A4enzyme
TerlipressinVasopressin V1a receptortarget
TerlipressinVasopressin V2 receptortarget
TerlipressinVasopressin V1b receptortarget
AtosibanOxytocin receptortarget
AtosibanVasopressin V1a receptortarget
AtosibanVasopressin V1b receptortarget
AtosibanVasopressin V2 receptortarget
Corifollitropin alfaFollicle-stimulating hormone receptortarget
SomatremGrowth hormone receptortarget
SomatremInsulin-like growth factor 1 receptortarget
BremelanotideMelanocyte-stimulating hormone receptortarget
BremelanotideMelanocortin receptor 4target
BremelanotideMelanocortin receptor 3target
BremelanotideMelanocortin receptor 5target
BremelanotideAdrenocorticotropic hormone receptortarget
LypressinVasopressin V1a receptortarget
LypressinVasopressin V2 receptortarget
LypressinVasopressin V1b receptortarget
LypressinCanalicular multispecific organic anion transporter 1transporter